Relevant bibliographies by topics / Ts polymorphism

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Ts polymorphism'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Ts polymorphism"

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Kim, Jung Oh, Han Sung Park, Eun Ju Ko, et al. "The 3′-UTR Polymorphisms in the Thymidylate Synthase (TS) Gene Associated with the Risk of Ischemic Stroke and Silent Brain Infarction." Journal of Personalized Medicine 11, no. 3 (2021): 200. http://dx.doi.org/10.3390/jpm11030200.

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Thymidylate synthase (TS) is a key gene involved in the repair of DNA damage and DNA synthesis that plays an important role in vascular development and recovery. In particular, TS gene polymorphisms play a major role in the progression of vascular disease and cancer metastasis. Therefore, the aim of this study was to investigate the association of three TS polymorphisms (1100T>C [rs699517], 1170A>G [rs2790], and 1494ins/del [rs151264360]) with ischemic stroke and silent brain infarction (SBI) in Koreans. A total of 1299 participants (507 stroke patients, 383 SBI patients, and 409 control
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Ugrasena, I. Dewa Gede, Harianto Notopuro, Subijanto Marto Sudarmo, Ketut Sudiana, Djajadiman Gatot, and Ponpon Idjradinata. "MTHFR C677T and TS 5’-UTR 3R/3R Gene Polymorphism in Methotrexate-Resistant Childhood Acute Lymphoblastic Leukemia." Indonesian Biomedical Journal 12, no. 2 (2020): 177–82. http://dx.doi.org/10.18585/inabj.v12i2.1109.

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BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy in Indonesia and often treated by methotrexate (MTX). Though it can be cured in 30-60% of patients, MTX resistance remains the major cause of treatment failure in childhood ALL. Previous sudies showed that its anti-leukemic property was moderated by MTX ability to inhibitmethylene tetra hydrofolate reductase (MTHFR) and thymidylate synthase (TS) in folate metabolism. This study investigates the correlation between MTHFR and TS polymorphism and MTX resistance in ALL children.METHODS: A total of 155
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Chen, Jin-Yin, He-Jian Chen, and Pei-Feng Chen. "Association of expression and genotypes of thymidylate synthase in non-small cell lung cancer patients with different clinicopathological characteristics." Pteridines 32, no. 1 (2021): 39–47. http://dx.doi.org/10.1515/pteridines-2020-0013.

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Abstract Objective To explore the expression and genotypes of thymidylate synthase (TS) in patients of non-small cell lung cancer (NSCLC) with different clinicopathological characteristics. Methods The expression profiles of TS were examined by immunohistochemical staining and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) in 160 patients with NSCLC. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect TS-5′UTR tandem repeats, G/C nucleotide polymorphisms, and 3′UTR 6 bp deletion/insertion polymorphisms. The relation
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Fariña-Sarasqueta, A., M. J. E. M. Gosens, E. Moerland, et al. "TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients." Analytical Cellular Pathology 33, no. 1 (2010): 1–11. http://dx.doi.org/10.1155/2010/731873.

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Aim: Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy.Patients and Methods: 251 patients diagnosed with stage III colon carcinoma treated with surgery followed by 5-FU based adjuvant therapy were selected. The variable number of tandem repeat
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Villafranca, Elena, Yury Okruzhnov, Miguel A. Dominguez, et al. "Polymorphisms of the Repeated Sequences in the Enhancer Region of the Thymidylate Synthase Gene Promoter May Predict Downstaging After Preoperative Chemoradiation in Rectal Cancer." Journal of Clinical Oncology 19, no. 6 (2001): 1779–86. http://dx.doi.org/10.1200/jco.2001.19.6.1779.

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PURPOSE: Thymidylate synthase (TS) is an important target enzyme for the fluoropyrimidines. TS gene promoter possesses regulatory tandemly repeated (TR) sequences that are polymorphic in humans, depending on ethnic factors. These polymorphisms have been reported to influence TS expression. TS expression levels affect tumor downstaging after preoperative fluoruracil (5-FU)–based chemoradiation. Tumor downstaging correlates with improved local control and disease-free survival. The aim of this study is to correlate TR polymorphisms with downstaging and disease-free survival. PATIENTS AND METHODS
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Ugrasena, IDG, Sutaryo Sutaryo, Edy Supriadi, et al. "High frequency of the 3R/3R polymorphism in the thymidylate synthase enhancer region in Indonesian childhood acute lymphoblastic leukemia." Paediatrica Indonesiana 46, no. 3 (2016): 103. http://dx.doi.org/10.14238/pi46.3.2006.103-12.

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Background Deoxyuridylate monophosphate (dTMP) is neces-sary for DNA synthesis and thymidylate synthase (TS) is an im-portant target of cancer chemotherapy. Ethnic variations of thepolymorphic tandem repeat sequence in the enhancer region ofthe TS promoter has previously been described to influence theoutcome of acute lymphoblastic leukemia (ALL). A triple repeat isassociated with a higher TS gene expression than a double re-peat, resulting in poorer outcome of ALL patients treated with anti-folate methotrexate (MTX).Objective In this study, we determined the incidences of TS andmethylenetetra
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Ichikawa, W., T. Takahashi, and Y. Sasaki. "Pharmacogenetic profiling and clinical outcome of patients (pts) with advanced gastric cancer (AGC) treated with S-1 monotherapy." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4600. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4600.

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4600 Background: Intra-tumor gene expressions of thymidylate synthase (TS) and orotate phosphoribosyltranseferase (OPRT) have been indicated to be positive predictive markers for the clinical outcome of pts treated by S-1 monotherapy for AGC (Int J Cancer 119:1245,2006). The aim of this study is to investigate whether polymorphisms with putative influence on S-1 activity are associated with clinical outcomes of pts with AGC. Patients and Methods: The study population consisted of consecutive 55 pts with AGC from 01/1999 to 03/2002 in our institute. All patients homogenously received the S-1 mo
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Kim, Jung Oh, Chang Soo Ryu, Jeong Yong Lee, et al. "Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease." International Journal of Molecular Sciences 24, no. 16 (2023): 12591. http://dx.doi.org/10.3390/ijms241612591.

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Coronary artery disease (CAD) is a prevalent cardiovascular condition characterized by the accumulation of plaque within coronary arteries. While distinct features of CAD have been reported, the association between genetic factors and CAD in terms of biomarkers was insufficient. This study aimed to investigate the connection between genetic factors and CAD, focusing on the thymidylate synthase (TS) gene, a gene involved in DNA synthesis and one-carbon metabolism. TS plays a critical role in maintaining the deoxythymidine monophosphate (dTMP) pool, which is essential for DNA replication and rep
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Mulder, K. E., C. A. Butts, A. Scarfe, et al. "A prospective pharmacogenetic study of thymidylate synthase (TS) polymorphisms in high risk stage II or stage III colon cancer patients treated with 5-fluorouracil (5-FU) and leucovorin (LV)." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13018. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13018.

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13018 Background: Retrospective studies suggest TS polymorphisms predict toxicity from TS inhibitors as well as therapeutic response. The TS promoter has a variable number of tandem repeats (VNTR) polymorphism containing putative E-box binding sites that bind upstream stimulatory factor (USF) -1 and -2. One E-box binding site exists in TSER*2 and 2 binding sites exist in TSER*3. A single nucleotide polymorphism (SNP) at position 12 (G→C) in TSER*3’s 2nd repeat abolishes binding of USF-1/2. Combined effects of VNTR and SNP means individuals may have 2, 3 or 4 enhancer regions. We hypothesized t
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Knop, Stefan, Juergen Loeffler, Michael Steffens, et al. "Polymorphisms in Genes of Folate Metabolism and Response to High-Dose Methotrexate in Patients with Primary Central Nervous System Lymphoma." Blood 106, no. 11 (2005): 4439. http://dx.doi.org/10.1182/blood.v106.11.4439.4439.

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Abstract The antifolate methotrexate (MTX) was shown to be the single most-effective agent in first-line treatment of patients with primary central nervous system lymphoma (PCNSL) when given intravenously in high doses. MTX inhibits 5,10-methylentetrahydrofolate reductase (MTHFR) as well as thymidylate synthase (TS) in target cells what eventually results in decreased DNA synthesis. Intracellular uptake of both folate and MTX is mediated by the reduced folate carrier (RFC). Genetic polymorphisms for all three proteins were described: a C to T base transition at nucleotide 667 (C677T) and an A
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Dissertations / Theses on the topic "Ts polymorphism"

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LOTTO, VALENTINA. "Nutrient-gene interactions within one-carbon metabolism and effects on epigenetic regulation through dna methylation in peripheral blood mononuclear cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/18016.

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Epigenetics is a field of molecular biology that copes with the study of gene function regulation without variations in DNA structure or nucleotide sequences. Among the main epigenetic phenomema in eukaryotic cells there are DNA methylation and post-traslational mechanisms among which the major are histone methylation and acetylation. Epigenetic changes are potentially reversible phenomena that are controlled also by nutritional factors as the methyl-donors involved in the folate cycle. Plasma levels of B vitamins, among which “in primis” plasma folate concentrations, are implicated in epig
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Hinkle, David T. "CORRELATING IRINOTECAN AND CAPECITABINE TREATMENT FOR COLORECTAL CANCER TO GENE EXPRESSION, POLYMORPHISMS, AND CLINICAL OUTCOMES." Thesis, 2011. http://hdl.handle.net/1805/2510.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Colorectal cancer is the third most common type of cancer and the third most common cause of cancer-related mortality. There are three types of treatment available to patients, either individually or in combination. Treatments are radiation, chemotherapy, and surgery. In a Phase II clinical trial at IUSM, a multimodality approach was chosen. The patients with locally advanced rectal cancer received preoperative treatment with capecitabine and irinotecan (CPT-11) combination followed by chemoradiation with capecitabine and finally sur
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Book chapters on the topic "Ts polymorphism"

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Clayton, Peter, Pierre Chatelain, Elena Bashnina, et al. "Using Single Nucleotide Polymorphisms (SNPs) To Predict Year 1 and Year 2 Growth Response to Growth Hormone (GH) Therapy in Children with GH Deficiency (GHD) and Turner Syndrome (TS)." In CLINICAL/TRANSLATIONAL - Growth Disorders. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part2.p19.p1-736.

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Chatelain, Pierre, Peter Clayton, Valentina Peterkova, et al. "Comparison of Single Nucleotide Polymorphisms (SNPs) Associated with Growth Response at Years 1 and 2 on Growth Hormone (GH) Therapy in Children with GH Deficiency (GHD) and Turner Syndrome (TS)." In CLINICAL/TRANSLATIONAL - Growth Disorders. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part2.p19.p1-735.

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