Relevant bibliographies by topics / Ts-reporter

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Academic literature on the topic 'Ts-reporter'

Author: Grafiati
Published: 28 June 2021
Last updated: 29 July 2025

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Journal articles on the topic "Ts-reporter"

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LEE, Kuan-Der, Seung Joon BAEK, and Rong-Fong SHEN. "Multiple factors regulating the expression of human thromboxane synthase gene." Biochemical Journal 319, no. 3 (1996): 783–91. http://dx.doi.org/10.1042/bj3190783.

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Characterization of the 5.5 kb promoter of human thromboxane synthase (TS) gene revealed a proximal positive regulatory sequence (PPRS, -90 to -25 bp) and several distal repressive elements. The maximal promoter activity was found to reside within the first 285 bp, ∼75% of which was contributed by the PPRS. The sequence between -365 and -665 bp exerted a strong repressive effect (∼55%) on reporter gene expression independent of orientation and position, consistent with properties expected for a silencer. The sequence upstream of -665 bp to -5.5 kb contains mainly repressive elements which furt
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2

Siddiqui, Mohammad Aarif, Paradesi Naidu Gollavilli, Vignesh Ramesh, et al. "Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer." British Journal of Cancer 124, no. 1 (2020): 281–89. http://dx.doi.org/10.1038/s41416-020-01095-x.

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Abstract Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT’s different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT transcription factor ZEB1 in NSCLC and imparts resistance against anti-folate chemotherapy. In this study, we establish a functional correlation between TS, EMT, chemotherapy and metastasis and propose a network for TS mediated EMT. Methods Published datasets were analyse
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Gribaudo, Giorgio, Ludovica Riera, Thomas L. Rudge, Patrizia Caposio, Lee F. Johnson, and Santo Landolfo. "Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts." Journal of General Virology 83, no. 12 (2002): 2983–93. http://dx.doi.org/10.1099/0022-1317-83-12-2983.

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Productive infection of non-proliferating cells by cytomegalovirus (CMV) requires the coordinated stimulation of host biochemical pathways that prepare cells to synthesize DNA. Here we illustrate the ability of human CMV (HCMV) to stimulate cellular thymidylate synthase (TS) gene expression in quiescent human embryonic lung fibroblasts. TS mRNA and protein levels are nearly undetectable in quiescent cells, but are greatly increased following HCMV infection. Inhibition of TS activity was shown to impair HCMV DNA synthesis, demonstrating that TS upregulation is required for efficient HCMV replic
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Gribaudo, Giorgio, Ludovica Riera, David Lembo, et al. "Murine Cytomegalovirus Stimulates Cellular Thymidylate Synthase Gene Expression in Quiescent Cells and Requires the Enzyme for Replication." Journal of Virology 74, no. 11 (2000): 4979–87. http://dx.doi.org/10.1128/jvi.74.11.4979-4987.2000.

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ABSTRACT Herpesviruses accomplish DNA replication either by expressing their own deoxyribonucleotide biosynthetic genes or by stimulating the expression of the corresponding cellular genes. Cytomegalovirus (CMV) has adopted the latter strategy to allow efficient replication in quiescent cells. In the present report, we show that murine CMV (MCMV) infection of quiescent fibroblasts induces both mRNA and protein corresponding to the cellular thymidylate synthase (TS) gene, which encodes the enzyme that catalyzes the de novo synthesis of thymidylic acid. The increase in TS gene expression was due
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Kaytor, M. D., and D. M. Livingston. "Saccharomyces cerevisiae RAD52 alleles temperature-sensitive for the repair of DNA double-strand breaks." Genetics 137, no. 4 (1994): 933–44. http://dx.doi.org/10.1093/genetics/137.4.933.

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Abstract We have screened for mutations of the Saccharomyces cerevisiae RAD52 gene which confer a temperature-sensitive (ts) phenotype with respect to either the repair of DNA lesions caused by methyl methanesulfonate (MMS) or the recombination of an intrachromosomal recombination reporter. We were readily able to isolate alleles ts for the repair of lesions caused by MMS but were unable to find alleles with a severe ts deficiency in intrachromosomal recombination. We extensively characterized four strains conferring ts growth on MMS agar. These strains also exhibit ts survival when exposed to
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6

Fenn, Kathleen, Veena M. Singh, Shing Mirn Lee, et al. "Diagnosis of leptomeningeal metastasis (LM) through identification of circulating tumor cells (CTCs) in cerebrospinal fluid (CSF)." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3567. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3567.

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3567 Background: Diagnosis of LM from solid tumors can be challenging. The TargetSelector (TS) CTC detection assay has demonstrated highly specific and sensitive CTC capture both for epithelial (CK+) and non-epithelial (CK-) subsets. The assay utilizes a ten-antibody (ab) capture cocktail followed by biotinylated secondary abs that bind to CTCs, enriched in a microfluidic device. TS targeted next-generation sequencing (NGS) assay detects somatic mutations in 12 breast cancer-related genes. The aim was to determine whether TS can improve sensitivity in the diagnosis of LM compared to CSF cytolo
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Kim, Eui Hyun, and Seok-Gu Kang. "CSIG-25. DIFFERENTIAL YAP ACTIVITY IN HUMAN GLIOBLASTOMA TUMORSPHERES AS A POTENTIAL BIOMARKER." Neuro-Oncology 24, Supplement_7 (2022): vii44. http://dx.doi.org/10.1093/neuonc/noac209.174.

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Abstract BACKGROUND Hippo/YAP signaling pathway has emerged as an important driver of GBM. However, the clinical significance and expression correlation of YAP in GBM is still unknown. The purpose of this study is to elucidate the regulatory functions of YAP in response to tumorspheres (TS) in GBM. Material and METHODS In GBM-tumorspheres (TS), mRNA levels of Yap1 and TAZ were determined by RNA-Seq, and nuclear YAP1 expression level and its correlation with tumor aggressiveness were assessed through nucleus cytosolic fractionation, quantitative confocal microscopy, western blot, and TEAD4 repo
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Ratinier, Maxime, Steeve Boulant, Christophe Combet, Paul Targett-Adams, John McLauchlan, and Jean-Pierre Lavergne. "Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1." Journal of General Virology 89, no. 7 (2008): 1569–78. http://dx.doi.org/10.1099/vir.0.83614-0.

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Since the first report of frameshifting in HCV-1, its sequence has been the paradigm for examining the mechanism that directs alternative translation of the hepatitis C virus (HCV) genome. The region encoding the core protein from this strain contains a cluster of 10 adenines at codons 8–11, which is thought to direct programmed ribosomal frameshifting (PRF), but formal evidence for this process has not been established unequivocally. To identify the mechanisms of frameshifting, this study used a bicistronic dual luciferase reporter system in a coupled transcription/translation in vitro assay.
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Tomikawa, Junko, Shuji Takada, Kohji Okamura, et al. "Exploring trophoblast-specific Tead4 enhancers through chromatin conformation capture assays followed by functional screening." Nucleic Acids Research 48, no. 1 (2019): 278–89. http://dx.doi.org/10.1093/nar/gkz1034.

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Abstract Tead4 is critical for blastocyst development and trophoblast differentiation. We assayed long-range chromosomal interactions on the Tead4 promoter in mouse embryonic stem (ES) cells and trophoblast stem (TS) cells. Using luciferase reporter assays with ES and TS cells for 34 candidate enhancer regions, we identified five genomic fragments that increased Tead4 promoter activity in a TS-specific manner. The five loci consisted of three intra- and two inter-chromosomal loci relative to Tead4 on chromosome 6. We established five mouse lines with one of the five enhancer elements deleted a
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Otsuka, Kai, Hong Yang, Shin Matsubara, et al. "Evidence for a functional role of Start, a long noncoding RNA, in mouse spermatocytes." PLOS ONE 17, no. 8 (2022): e0273279. http://dx.doi.org/10.1371/journal.pone.0273279.

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A mouse testis-specific long noncoding RNA (lncRNA), Start, is localized in the cytosol of Leydig cells and in the nucleus of pachytene spermatocytes. We previously showed that Start regulates steroidogenesis through controlling the expression of Star and Hsd3b1 genes in Leydig cells, but its function in germ cells was not known. Here we verified that a spermatocyte-specific protease gene, Prss43/Tessp-3, was downregulated in Start-knockout testes. To investigate the transcriptional regulatory activity of Start in spermatocytes, we first performed a series of reporter gene assays using a thymi
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Dissertations / Theses on the topic "Ts-reporter"

1

Naňo, Andrej. "Automatické generování testovacích dat informačních systémů." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2021. http://www.nusl.cz/ntk/nusl-445520.

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ISAGENis a tool for the automatic generation of structurally complex test inputs that imitate real communication in the context of modern information systems . Complex, typically tree-structured data currently represents the standard means of transmitting information between nodes in distributed information systems. Automatic generator ISAGENis founded on the methodology of data-driven testing and uses concrete data from the production environment as the primary characteristic and specification that guides the generation of new similar data for test cases satisfying given combinatorial adequac
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