Academic literature on the topic 'TSCE Model'

The design and development of process-aware information systems is often supported by specifying requirements as business process models. Although this approach is generally accepted as an effective strategy, it remains a fundamental challenge to adequately validate these models given the diverging skill set of domain experts and system analysts. As domain experts often do not feel confident in judging the correctness and completeness of process models that system analysts create, the validation often has to regress to a discourse using natural language. In order to support such a discourse appropriately, so-called verbalization techniques have been defined for different types of conceptual models. However, there is currently no sophisticated technique available that is capable of generating natural-looking text from process models. In this paper, we address this research gap and propose a technique for generating natural language texts from business process models. A comparison with manually created process descriptions demonstrates that the generated texts are superior in terms of completeness, structure, and linguistic complexity. An evaluation with users further demonstrates that the texts are very understandable and effectively allow the reader to infer the process model semantics. Hence, the generated texts represent a useful input for process model validation.

La maggior parte dei pazienti affetti da Sclerosi Tuberosa mostra lesioni ossee di tipo sclerotico, la cui patogenesi e’ sconosciuta. Le lesioni sclerotiche potrebbero rappresentare un eccessivo e focale accumulo di osso. Lo scheletro e’ continuamente rimodellato dall’azione di osteoblasti, le cellule che producono tessuto osseo e osteoclasti (OC), che lo degradano. Evidenze dimostrano che la perdita di TSC1 o TSC2 negli osteoblasti ha effetto negativo nella maturazione dello scheletro, ma la funzione del complesso TSC1-TSC2 negli OC non e’ noto. Per identificare il ruolo di TSC2 negli OC abbiamo incrociato un topo CtskCRE, in cui Cre e’ espresso negli OC, con un topo Tsc2fl/fl per generare un topo CtskCre; Tsc2fl/fl ora in avanti chiamato Tsc2ΔOC. I topi Tsc2ΔOC maschi presentano un incremento di 3 volte della quantita’ di osso trabecolare a 9 mesi di eta’ (p< 0.01), cosi’ come dello spessore della corticale ossea (1.5 volte, p<0.05). Caratteristiche simili sono osservate a 3 mesi di eta’. Come pronosticato, gli OC derivati da topi Tsc2ΔOC hanno elevazione di mTORC1 ma presentano una normale maturazione ed una normale attivita’ secretoria in vitro. Per studiare la funzione degli OC in vivo, abbiamo misurato i livelli sierici di CTX1, un marker della loro attivita’, trovandolo normale sia nei topi maschi che nelle femmine a 3 mesi di eta’, normale nelle femmine a 9 mesi di eta’ ed aumentato nei maschi a 9 mesi di eta’. La concentrazione sierica di P1NP, un marker di attivita’ degli osteoblasti e’ stata trovata elevata in tutti i gruppi considerati. Gli OC aumentano l’attivita’ degli osteoblasti mediante la secrezione di clastochine, un meccanismo chiamato coupling. L’ RNA messaggero di CTHRC1 (una clastochina) e’ aumentato di 11 volte (p<0.001) nei femori di topi Tsc2ΔOC a 3 mesi cosi come a 9 mesi di eta’. Il nostro modello suggerisce che la perdita di TSC2 negli OC possa stimolare gli osteoblasti a produrre osso tramite la mTORC1 dipendente secrezione di CTHRC1.<br>The majority of TSC patients have sclerotic bone lesions, the pathogenesis of which is unknown. Sclerotic lesions may represent focal accumulation of excess bone. Normal bone is continuously remodeled by the actions of bone forming osteoblasts and bone resorbing osteoclasts (OC). A growing body of evidence suggests that loss of TSC1 or TSC2 in osteoblasts impacts normal skeletal growth, but the function of the TSC protein complex in OC is unknown. To examine the impact of the TSC2 protein in OC, we crossed the Cathepsin K-Cre (Ctsk-Cre) mice, where Cre is expressed in OC, with Tsc2fl/fl mice to generate CtskCre; Tsc2fl/fl mice, subsequently denoted as Tsc2ΔOC. Tsc2ΔOC male mice have strikingly elevated trabecular bone mass at 9 months of age (~3-fold increase, p<0.01) as well as increased cortical thickness (1.5-fold, p<0.05). Similar characteristics were observed at 3 months of age. As expected, OCs from Tsc2ΔOC mice had increased mTORC1 activity, consistent with the loss of TSC2, however they show normal maturation and secretory function in vitro. To assess OC function in vivo, we measured serum levels of the degradation products of C-terminal telopeptide of type I collagen (CTX-I), an established bone resorption marker. CTX-I was found normal in male and females at 3 months of age and in 9 months old female; slightly elevated in male at 9 month of age meaning OCs are not responsible for the phenotype. The serum concentration of procollagen type I N propeptide (P1NP), a marker of osteoblast activity, was elevated in Tsc2ΔOCmice in both sex at 3 and 9 months of age. OCs increase osteoblast activity through the secretion of Clastokines, a mechanism called coupling. CTHRC1 (a clastokine) mRNA was found increased (11 fold, p< 0.001) in the femurs of 3 months old Tsc2ΔOC mice, as well as at 9 months old. Our model suggests that loss of Tsc2 in OCs may stimulate osteoblastic bone formation through the mTORC1 dependent secretion of CTHRC1.

LAM is a rare and progressive disease characterized by widespread proliferation of abnormal smooth muscle-like cells (LAM cells). LAM cells cause cystic destruction of lung parenchyma, abdominal tumours (angiomyolipoma, AML) and infiltration of axial lymphatics in torax and abdomen (adenopathy and lymphangioleiomyoma). LAM occurs sporadically or in association with tuberous sclerosis complex (TSC), an inherited disorder with variable penetrance, which results from mutations in TSC1 or TSC2 genes. TSC1 or TSC2 genes, encoding hamartin and tuberin respectively, regulate mammalian target of rapamycin (mTOR). LAM affects primarly women of child-bearing age and the mechanisms causing the disease are not yet clarified. To explain the multisystemic clinical manifestations of LAM an experimental model is needed to study the pathological mechanism causing LAM. It may help to explain how LAM cells migrate from tissue to tissue and to develop a pharmacological approach. We recently isolated and characterized α-actin positive smooth muscle cells from chylous of a patient affected by LAM/TSC (LAM/TSC cells). These circulating cells showed reactivity to HMB45 and CD44v6 antibodies, markers of TSC and LAM, and bear a germline TSC2 mutation in exon 21. Like TSC2 smooth muscle cells previously isolated (TSC2-/- and TSC2-/meth ASM cells), LAM/TSC cells from chylous required epidermal growth factor (EGF) to proliferate and the blockade of EGF receptor (EGFR) caused progressive cell death. To better study LAM pathogenesis we developed a procedure for a quick invasion of the respiratory system by endonasally administrating LAM/TSC cells. LAM/TSC cells were administrated in immunodeficient female nude mice (nu/nu Hsd: athymic nude mice, 3 weeks old) and after 26 weeks anti-EGFR antibody and rapamycin were intraperitoneally injected 2 times a week for 4 weeks. 30 weeks after endonasal administration LAM/TSC cells were detected in lungs, lymph nodes and uterus. In lung parenchyma, LAM/TSC cells proliferated and caused cystic destruction with emphysematous-like picture such as in LAM patient lungs. This lesion and the proliferating rate were reverted by anti-EGFR antibody, while rapamycin was less effective and caused hemoptysis. In lungs blood vessel number was increased and, using LYVE-1 antibody, a significant increase of lymphatic vessel density (LVD) was observed in animals that received LAM/TSC cells suggesting a possible correlation between LAM/TSC cells and lymphangiogenesis. LVD decreased following anti-EGFR antibody and rapamycin treatments. When treatments were stopped, hemoptysis caused by rapamycin was reverted. Anti-EGFR antibody was more effective than rapamycin in reducing lung injury caused by LAM/TSC cells administration and in decreasing lymphangiogenesis. In some lung parenchyma noduli were detected. Such in lungs of LAM patients they were positive to human COX IV, ER, PR and phosphoS6. In lymph nodes, LAM/TSC cells promoted a lymphatic vessel invasion, as showed by PROX-1-reactivity. Anti-EGFR antibody and rapamycin treatments decreased lymphatic vessels. Differently from lungs, blood vessels in lymph nodes were not altered after LAM/TSC cells administration, as shown by CD31 immunoreactivity. LAM/TSC cells were also detected in uteri where they promoted a significant increase of cells with high levels of estrogen (ER) and progesterone receptors (PR). In uteri afterLAM/TSC cells administration the morphological structure was unchanged. Pharmacological treatments decreased ER and PR expressions. Our data show that endonasal administration of cells isolated from chylous of LAM/TSC patient developed a mouse LAM model. LAM/TSC cells invaded lungs, lymph nodes and uteri causing LAM-like lesions. Anti-EGFR antibody is more effective than rapamycin in promoting lung restauration and reducing lymphangiogenesis; its efficacy persists also when treatment is stopped. These data suggest that anti-EGFR antibody treatment may represent a useful pharmacological approach for LAM therapy.

The prion diseases are neurodegenerative disorders of humans and animals that are sporadic or inherited in origin and can be transmitted. Despite remarkable differences in phenotypic expression, these disorders share a similar pathogenic mechanism, i.e. a posttranslational modification of the prion protein from a normal cellular isoform (PrPC) to insoluble and protease-resistant disease-specific species (termed PrPSc). PrPSc accumulates in the brain and, according to prion hypothesis, is responsible for the propagation of the pathologic process and transmissibility of the disease, by converting PrPC into a likeness of itself. In a model of prion replication, direct interaction between PrPSc template and the endogenous PrPC is proposed to drive the formation of nascent infectious prions. For these reasons therapies to prevent prion diseases can be targeted towards the selective binding of PrPC or PrPSc and the process of conversion. Many compounds have been proposed as potential therapies in the treatment of prion diseases. With the development of novel gene delivery system and nanomedicine, it has been possible to design innovative in vitro therapies effective in cure chronically prion infected cells. ScFvD18, an antibody fragment composed by the variable regions of the heavy and light chains, already resulted in efficient clearing PrPSc in prion infected cells. Fo this reason, ScFvD18 was engineered in Adeno-Associated Viral vectors (AAVs) serotype 9 (AAV9-ScFvD18) and inoculated into the brain of prion infected mice to assess its effectiveness in modify disease progression. Also polyelectrolyte covered gold nanoparticles (AuNPs) are excellent therapeutic compounds due to the intrinsic properties as being non-toxic, inert to most chemical reactions and easy to prepare. In vitro experiments showed that even picomolar amount of AuNPs with layer-wise deposition of oppositely charged synthetic polyelectrolytes, such as polyallylamine hydrochloride (PAH)and polystyrenesulfonate (PSS), were able to hamper the accumulation of PrPSc in cell culture. The efficacy of these nanogold particles was further assessed in prion infected mice.

Flexible AC Transmission Systems (FACTS) have the ability of voltage supportand increase transmission capacity. In order to specify a FACTS devicethat is performing according to expectations in a network, a set of studiesand network analyses must be performed. Part of these studies are done usingpower system analysis programs such as PSS®E, which is a planning toolsimulating large power systems in phasor domain using RMS values. Theseplanning tools are used for evaluating stability and reinforcement needs ina power system. The results play a vital role in investment decisions inthe power system. FACTS devices are modeled in PSS®E using a programminglanguage called FORTRAN. It is important to model FACTS devicesaccurately to avoid misleading results. In this Master thesis, STATCOMand Hybrid-STATCOM models are proposed and programmed accordingto ABB’s control strategy. The models are tested in PSS®E and verifiedagainst detailed models in PSCAD. Also, the models are compared againstother industry wide spread generic models.<br>System inom produktgruppen FACTS (Flexible AC Transmission Systems)har m¨ojligheten att st¨odja sp¨anning och h¨oja ¨overf¨oringskapacitet p°a existerandeledningar. F¨or att kunna specificera en FACTS-anl¨aggning sombeter sig som f¨orv¨antat i ett eln¨at beh¨ovs ett antal studier och n¨atanalyserutf¨oras. Delar av dessa studier ¨ar gjorda genom att anv¨anda verktyg f¨orkraftsystemanalys som t.ex. PSS®E, som ¨ar ett verktyg f¨or n¨atplaneringd¨ar fasvektorer och RMS-v¨arden anv¨ands i ber¨akningarna. Dessa verktyganv¨ands f¨or att evaluera stabilitet och utbyggnadsbehov i eln¨atet. Resultatenfr°an verktygen spelar en vital roll i investeringsbeslut i ett eln¨at.FACTS-system modelleras i PSS®E med hj¨alp av programmeringsspr°aketFORTRAN. Det ¨ar viktigt att anv¨anda korrekta modeller f¨or att undvikamissledande resultat. I denna Master-uppsats f¨oresl°as och utvecklasSTATCOM och Hybrid-STATCOM modeller i enlighet med ABBs kontrollstrategi.Modellerna testas i PSS®E och verifieras mot detaljerade modelleri PSCAD. Modellerna j¨amf¨ors ¨aven mot andra generiska modeller som ¨araccepterade och spridda ¨over branschen i stort.

Le travail présenté dans cette thèse concerne la mise en oeuvre numérique de techniques temporelles pour des applications en compatibilité électromagnétique (CEM) impulsionnelle, essentiellement pour des études en chambre réverbérante à brassage de modes (CRBM). Prenant le contre-pied des approches fréquentielles, adaptées par nature aux études de cavités résonantes, l’idée directrice de ce mémoire a été d’étudier des moyens temporels originaux d’investigation de CRBM en vue de proposer de nouveaux paradigmes pour la caractérisation d’équipements. Originellement développé en acoustique, le processus de retournement temporel (RT) récemment appliqué aux ondes électromagnétiques permet une focalisation spatiale et temporelle de ces dernières d’autant meilleur que le milieu de propagation est réverbérant. Les chambres réverbérantes (CR) sont ainsi des endroits idéaux pour l’application du processus de RT. Après une nécessaire étude des nombreux paramètres qui gouvernent ce dernier couplée à la définition de méthodologies numériques spécifiques, les applications du RT en CRBM sont exposées. En particulier, l’intérêt d’une focalisation sélective pour des tests en susceptibilité rayonnée est démontré. L’importance des coefficients d’absorption et de diffraction des équipements en CRBM justifie leur caractérisation précise et efficace. À cette fin, la mise en oeuvre d’un calcul temporel de section efficace totale de diffraction (TSCS en anglais) est détaillée. L’application de cette nouvelle technique à différentes formes de brasseurs de modes permet au final de confronter ces résultats avec ceux obtenus à l’aide de tests normatifs CEM<br>The work presented in this thesis concerns the use of time techniques for impulsive ElectroMagnetic Compatibility (EMC) applications, mainly for Modes Stirred Reverberation Chamber (MSRC) studies. Contrary to approaches from frequency domain, obviously well-fitted for studies in resonant cavities, the main idea of this thesis was to study an original time method for MSRC investigation to propose new paradigms for equipment characterization. Originally developed in acoustics, the Time Reversal (TR) process recently applied to electromagnetic waves allows focusing it both in time and space. The process quality is even higher if the propagation environment is reverberant. Thus, the Reverberation Chambers (RC) are an ideal locations for TR implementation. After a study of parameters involved in the TR process coupled with the definition of specific numerical methods, the applications of TR in MSRC are exposed. In particular, the interest of selective focusing for radiated susceptibility tests is demonstrated. The importance of absorption and diffraction coefficients for MSRC equipment justifies their accurate and efficient characterization. To this end, the implementation of a temporal calculation of the Total Scattering Cross Section (TSCS) in RC is detailed. The application of this new technique to different forms of stirrers allows finally to face these results with those obtained from standard EMC test

“Does overnight information play an important role in predicting daytime volatility in the financial markets?” This is an unresolved question in the literature on financial volatility. Due to the global integration of financial markets, the need for market efficiency is becoming more pronounced. More specifically, the need to account for information on the overnight or non-trading period is even more pertinent in contexts such as the Australian Stock Exchange (ASX) and the Tokyo Stock Exchange (TSE), because their geographical proximity means that they are outside the trading hours of major global markets such as the New York Stock Exchange (NYSE) and the London Stock Exchange (LSE). Thus, when a new business day dawns, much pertinent information is waiting to impact price developments.<br>Thesis (PhD Doctorate)<br>Doctor of Philosophy (PhD)<br>Griffith Business School<br>Griffith Business School<br>Full Text

Le travail présenté dans cette thèse concerne la mise en oeuvre numérique de techniques temporelles pour des applications en compatibilité électromagnétique (CEM) impulsionnelle, essentiellement pour des études en chambre réverbérante à brassage de modes (CRBM). Prenant le contre-pied des approches fréquentielles, adaptées par nature aux études de cavités résonantes, l'idée directrice de ce mémoire a été d'étudier des moyens temporels originaux d'investigation de CRBM en vue de proposer de nouveaux paradigmes pour la caractérisation d'équipements. Originellement développé en acoustique, le processus de retournement temporel (RT) récemment appliqué aux ondes électromagnétiques permet une focalisation spatiale et temporelle de ces dernières d'autant meilleur que le milieu de propagation est réverbérant. Les chambres réverbérantes (CR) sont ainsi des endroits idéaux pour l'application du processus de RT. Après une nécessaire étude des nombreux paramètres qui gouvernent ce dernier couplée à la définition de méthodologies numériques spécifiques, les applications du RT en CRBM sont exposées. En particulier, l'intérêt d'une focalisation sélective pour des tests en susceptibilité rayonnée est démontré. L'importance des coefficients d'absorption et de diffraction des équipements en CRBM justifie leur caractérisation précise et efficace. À cette fin, la mise en oeuvre d'un calcul temporel de section efficace totale de diffraction (TSCS en anglais) est détaillée. L'application de cette nouvelle technique à différentes formes de brasseurs de modes permet au final de confronter ces résultats avec ceux obtenus à l'aide de tests normatifs CEM.