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Relevant bibliographies by topics / TSPO binding

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Academic literature on the topic 'TSPO binding'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "TSPO binding"

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Iatmanen-Harbi, Soria, lucile Senicourt, Vassilios Papadopoulos, Olivier Lequin, and Jean-Jacques Lacapere. "Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO." International Journal of Molecular Sciences 20, no. 6 (2019): 1444. http://dx.doi.org/10.3390/ijms20061444.

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The optimization of translocator protein (TSPO) ligands for Positron Emission Tomography as well as for the modulation of neurosteroids is a critical necessity for the development of TSPO-based diagnostics and therapeutics of neuropsychiatrics and neurodegenerative disorders. Structural hints on the interaction site and ligand binding mechanism are essential for the development of efficient TSPO ligands. Recently published atomic structures of recombinant mammalian and bacterial TSPO1, bound with either the high-affinity drug ligand PK 11195 or protoporphyrin IX, have revealed the membrane pro

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Tong, Junchao, Belinda Williams, Pablo M. Rusjan, et al. "Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies." Journal of Cerebral Blood Flow & Metabolism 40, no. 5 (2019): 1061–76. http://dx.doi.org/10.1177/0271678x19858003.

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Positron emission tomography (PET) imaging of the translocator protein (TSPO) is widely used as a biomarker of microglial activation. However, TSPO protein concentration in human brain has not been optimally quantified nor has its regional distribution been compared to TSPO binding. We determined TSPO protein concentration, change with age, and regional distribution by quantitative immunoblotting in autopsied human brain. Brain TSPO protein concentration (>0.1 ng/µg protein) was higher than those reported by in vitro binding assays by at least 2 to 70 fold. TSPO protein distributed widely i

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Owen, David R., Astrid J. Yeo, Roger N. Gunn, et al. "An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28." Journal of Cerebral Blood Flow & Metabolism 32, no. 1 (2011): 1–5. http://dx.doi.org/10.1038/jcbfm.2011.147.

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[11C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain this. Binding affinity of PBR28 was measured in platelets isolated from 41 human subjects and tested for association with polymorphisms in TSPO and genes encoding other proteins in the

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Asih, Prita R., Anne Poljak, Michael Kassiou, Yazi D. Ke, and Lars M. Ittner. "Differential mitochondrial protein interaction profile between human translocator protein and its A147T polymorphism variant." PLOS ONE 17, no. 5 (2022): e0254296. http://dx.doi.org/10.1371/journal.pone.0254296.

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The translocator protein (TSPO) has been implicated in mitochondrial transmembrane cholesterol transport, brain inflammation, and other mitochondrial functions. It is upregulated in glial cells during neuroinflammation in Alzheimer’s disease. High affinity TSPO imaging radioligands are utilized to visualize neuroinflammation. However, this is hampered by the common A147T polymorphism which compromises ligand binding. Furthermore, this polymorphism has been linked to increased risk of neuropsychiatric disorders, and possibly reduces TSPO protein stability. Here, we used immunoprecipitation coup

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Berroterán-Infante, Neydher, Monika Tadić, Marcus Hacker, Wolfgang Wadsak, and Markus Mitterhauser. "Binding Affinity of Some Endogenous and Synthetic TSPO Ligands Regarding the rs6971 Polymorphism." International Journal of Molecular Sciences 20, no. 3 (2019): 563. http://dx.doi.org/10.3390/ijms20030563.

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An intriguing target involved in several pathophysiological processes is the 18 kDa translocator protein (TSPO), of which exact functions remained elusive until now. A single nucleotide polymorphism in the TSPO gene influences the binding affinity of endogenous and synthetic TSPO ligands by facilitating a lower-affinity conformation, which modifies a potential ligand binding site, ultimately leading to a binding profile classification according to each genotype. For instance, some clinical effects of the distinctive binding affinity profile of cholesterol toward the TSPO of individuals with di

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Kreisl, William C., Kimberly J. Jenko, Christina S. Hines, et al. "A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 33, no. 1 (2012): 53–58. http://dx.doi.org/10.1038/jcbfm.2012.131.

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Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or heterozygous (HL). We tested if in vitro binding to leukocytes distinguished TSPO genotypes and if genotype could affect clinical studies using the TSPO radioligand [11C]PBR28. In vitro binding to leukocytes and [11C]PBR28 brain imaging were performed in 27 human subjects with known TSPO genotype. Specific [3H]P

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Tournier, Benjamin B., Stergios Tsartsalis, Kelly Ceyzériat, et al. "Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding." Journal of Cerebral Blood Flow & Metabolism 40, no. 6 (2019): 1242–55. http://dx.doi.org/10.1177/0271678x19860408.

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Many studies have explored the role of TSPO (18 kDa translocator protein) as a marker of neuroinflammation using single-photon emission computed tomography (SPECT) or positron emission tomography (PET). In vivo imaging does not allow to determine the cells in which TSPO is altered. We propose a methodology based on fluorescence-activated cell sorting to sort different cell types of radioligand-treated tissues. We compared left/right hippocampus of rats in response to a unilateral injection of lipopolysaccharide (LPS), ciliary neurotrophic factor (CNTF) or saline. We finally applied this method

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Hiser, Carrie, Beronda L. Montgomery, and Shelagh Ferguson-Miller. "TSPO protein binding partners in bacteria, animals, and plants." Journal of Bioenergetics and Biomembranes 53, no. 4 (2021): 463–87. http://dx.doi.org/10.1007/s10863-021-09905-4.

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AbstractThe ancient membrane protein TSPO is phylogenetically widespread from archaea and bacteria to insects, vertebrates, plants, and fungi. TSPO’s primary amino acid sequence is only modestly conserved between diverse species, although its five transmembrane helical structure appears mainly conserved. Its cellular location and orientation in membranes have been reported to vary between species and tissues, with implications for potential diverse binding partners and function. Most TSPO functions relate to stress-induced changes in metabolism, but in many cases it is unclear how TSPO itself

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Vo, Sophie V., Samuel D. Banister, Isaac Freelander, et al. "Reversing binding sensitivity to A147T translocator protein." RSC Medicinal Chemistry 11, no. 4 (2020): 511–17. http://dx.doi.org/10.1039/c9md00580c.

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Wimberley, Catriona, Sonia Lavisse, Vincent Brulon, et al. "Impact of Endothelial 18-kDa Translocator Protein on the Quantification of 18F-DPA-714." Journal of Nuclear Medecine 59, no. 2 (2017): 307–14. https://doi.org/10.2967/jnumed.117.195396.

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Abstract <sup>18</sup>F-DPA-714 is a second-generation tracer for PET imaging of the 18-kDa translocator protein (TSPO), a marker of neuroinflammation. Analysis and interpretation of TSPO PET are challenging, especially because of the basal expression of TSPO. The aim of this study was to evaluate a compartmental model that accounts for the effect of endothelial TSPO binding on the quantification of <sup>18</sup>F-DPA-714 PET scans from a cohort of healthy subjects. <strong>Methods:</strong> Fifteen healthy subjects (9 high-affinity binders and 6 mixed-affinity binders) underwent <sup>18</sup>

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Dissertations / Theses on the topic "TSPO binding"

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Al-Saleem, Jacob Jamal. "Identification of HTLV-1 Tax-1 and HBZ Binding Partners, and Their Role in HTLV-1 Biology and Pathogenesis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479901289612684.

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Book chapters on the topic "TSPO binding"

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Kéri, Szabolcs. "Translocator protein (18 kDa TSPO) binding in depression." In The Neuroscience of Depression. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-817935-2.00030-1.

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Conference papers on the topic "TSPO binding"

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Bacon-Baguley, Theresa, Suzanne Kendra-Franczak та Daniel Walz. "THROMBOSPONDIN SPECIFICALLY INTERACTS WITH AMINO ACID SEQUENCES WITHIN THE A α- AND B β- CHAINS OF FIBRINOGEN". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643822.

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Thrombospondin (TSP) is responsible for the secretion-dependent phase of platelet aggregation. The mechanism of this action is believed to be through the binding of TSP to fibrinogen, resulting in the stabilization of the platelet aggregate. It has been established that the binding of fibrinogen to the platelet surface is dependent upon peptide sequences present, respectively, in the Aa- and y-chains. We have hypothesized that the binding of TSP to fibrinogen is also dependent upon unique fibrinogen peptide sequences. To test this hypothesis we have examined the interaction of TSP and f.ih.r.i

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DePoli, Patricia, Theresa Bacon-Baquley, and Daniel A. Walz. "THROMBOSPONDIN INTERACTION WITH PLASMINOGEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643824.

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Platelet thrombospondin (TSP) interacts with plasminogen in a specific and saturable manner. TSP can form a trimolecular complex with histidine-rich glycoprotein and plasminogen and the plasminogen within such complexes can reportedly be activated by tissue plasminogen activator. We have studied the interaction of TSP with plasminogen using Western blotting of plasminogen, reduced plasmin and the elastase-generated fragments of plasminogen and their binding of iodinated TSP. TSP was found to specifically bind to plasminogen and the heavy (non-enzyme) chain of plasmin in a calcium-independent m

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McGregor, J. L., and H. Boukerche. "NORMAL EXPRESSION OF THROMBOSPONDIN RECEPTOR SITES ON PLATELETS OF THREE GLANZMANN THROMBASTHENIC PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644740.

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A well characterised anti-thrombospondin (TSP) monoclonal antibody (Mab) LYP8 was used to investigate the presence of TSP receptors on Glanzmann thrombasthenic (G.T.) platelets. LYP8 inhibited platelet aggregation induced by low concentrations of thrombin (0.05 U/ml) or collagen (0.5 ug/ml). The presence of LYP8 did not affect the number of sites and Kd of 125I-fibrinogen binding to thrombin-stimulated normal platelets. Binding of LYP8 to normal platelets was minimal in whole blood (300 IgG molecules/ olatelet), increased in citrated PRP (1187 ± 209 IgG molecules/ platelet) and washed platelet

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Legrand, C., V. Dubernard, N. Kieffer, and A. T. Nurden. "USE OF A MONOCLONAL ANTIBODY TO MEASURE THE SURFACE EXPRESSION OF THROMBOSPONDIN FOLLOWING PLATELET ACTIVATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643821.

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A radiolabelled monoclonal antibody (mAb) against native thrombospondin (TSP) has been used to quantitatively assess the surface exposure of intracellular TSP following platelet stimulation. This mAb, designated 5G11, was purified from ascitic fluid by ammonium sulfate precipitation followed by chromatogloghy on DEAE Trisacryl. The isolated IgG were labelled with I by the chloramine T method (sp.act. 200-500 cpm/ ng). The specificity of the mAb was established by immunoblot-ting and crossed immunoelectrophoresis using platelet protein extracts. When the labelled IgG (20 μg/ml) were incubated w

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Nachman, R. L., R. L. Silverstein, and A. S. Asch. "THROMBOSPONDIN: CELL BIOLOGY OF AN ADHESIVE GLYCOPROTEIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644653.

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Thrombospondin (TSP), a multifunctional 450 KD glycoprotein is a secretory product of thrombin stimulated platelets. It is a major component of the platelets alpha granule constituting approximately 3% of total platelet protein. Thrombospondin does not circulate in appreciable concentrations ∽0 100 ng/ml); however, the tissue distribution is broad. In addition to its expression on the membrane of activated platelets, the protein is synthesized by fibroblasts endothelial cells, glial cell smooth muscle cells alveolar pneumocytes mononuclear phagocytes and various tumor cells. TSP is a major con

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Tuszynski, George P., Vicki L. Rothman, Andrew Murphy, et al. "Thranbospondin Promotes Cell-and Platelet-Substratum Adhesion." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643820.

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Thrombospondin (TSP), isolated from human platelets, promotes the in vitro, calcium-specific adhesion of a variety of cells, including platelets, melanoma cells, muscle cells, endothelial cells, fibroblasts, and epithelial cells. The cell adhesion-promoting activity of TSP is species independent since human, bovine, pig, rat and mouse cells all adhered to TSP. Furthermore, the cell adhesion-promoting activity of TSP is specific and not due to a nonspecific protein effect or to contamination by fibronectin, vitronectin, or laminin. That is, neither bovine serum albumin nor TSP preparations trea

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Schick, K. P., S. Shapiro, G. Tuszynski, and J. Slawek. "SULFATIDES AND GLYCOLIPIDS IN PLATELETS AND ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643641.

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Sulfatides are sulfated glycolipids which are negatively charged and thought to influence receptor mediated activities. Sulfatides have the capacity to provide a surface for the initiation of in vitro coagulation tests and these acidic lipids represent the potential biological surface for the initiation of the contact and intrinsic systems in vivo. Several sulfatides have been demonstrated in blood platelets. We have investigated sulfatides and other glycolipids in endothelial cells and platelets in order to define the cellular sources for sulfatides that would be available for influencing hem

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Cazenave, J.-P., A. Bay-Sutter, C. Gachet, F. Lanza, and A. Stierlé. "DISSOCIATION BY EDTA OF THE HUMAN PLATELET GP IIb-IIIa COMPLEX PREVENTS ADP-INDUCED FIBRINOGEN DEPENDENT AGGREGATION BUT NOT THROMBIN-INDUCED THROMBOSPONDIN DEPENDENT AGGREGATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643862.

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The aggregation of washed human platelets by ADP does not cause the release reaction and is dependent, following ADP binding to its receptor, on exposure of the membrane glycoprotein (GP) IIb-IIIa complex, platelet contact and presence in the external medium of Ca2+ and fibrinogen. EDTA, which chelates Ca2+ can inhibit platelet aggregation by removal of Ca2+ from external medium or by dissociating the GPIIb-IIIa calcium dependent complex. We have studied the effects of prolonged incubation of human platelets with EDTA on the platelet ADP-fibrinogen dependent aggregation. Human platelets were w

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Krstanović, Vinko, Krešimir Mastanjević, and Kristina Habschied. "The influence of milling granulation on the proportion of fermentable and non-fermentable ingredients in mash obtained from barley malt, unmalted wheat and wheat malt." In VII naučno-stručni simpozijum sa međunarodnim učešćem "Pivo, pivarske sirovine i tržište". Institute of Field and Vegetable Crops Research, Novi Sad, 2024. https://doi.org/10.5937/pivos24012k.

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This work is part of a wider research on the application of "hard red winter" type wheat, either as unmalted raw materialor as malt, from the domestic assortment as well as foreign varieties introduced into cultivation, since they have shown very good brewing properties. In addition to the above, they also have numerous agrotechnical advantages during cultivation. They are characterized by a mixed (marbled) texture of the grain endosperm, and although they belong to the "hard" type, during processing they show many characteristics characteristic of the "soft" type of wheat. The influence of th

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Gilbert, Charles. "Color processing in visual cortex." In Advances in Color Vision. Optica Publishing Group, 1992. http://dx.doi.org/10.1364/acv.1992.fc1.

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Wavelength specific cells in visual cortex are grouped together into compartments that are interdigitated between other compartments specializing in form, movement and depth. The first evidence for a functional organization of color based on cortical area came from the work of Semir Zeki, who described an area prestriate cortex, known as area V4, that was enriched for color specific cells. Other cortical areas also contained wavelength selective cells, but the precise distribution of these cells eluded investigators for a number of years until the discovery by Margaret Wong- Riley that in area

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