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1
Bonnet, Marie-Laure, Vincent Robert, Masahisa Tsuchiizu, Yukiko Omori, and Yoshikazu Suzumura. "Intramolecular charge ordering in the multi molecular orbital system (TTM-TTP)I3." American Institute of Physics, 2010. http://hdl.handle.net/2237/14165.
2
Cunliffe, Helen Elizabeth. "Transcriptional regulation of the anti-inflammatory protein tristetraprolin (TTP)." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6129/.
Abstract:
Feedback node genes (FNGs) are essential for negative feedback control of inflammatory responses. By definition, their expression is controlled by both pro- and anti-inflammatory stimuli, often in a cooperative manner. This thesis investigates three FNGs, namely Dual specificity phosphatase 1 (DUSP1), Tumour necrosis factor alpha inducible protein 3 (TNFAIP3) and Tristetraprolin (TTP, encoded by the \(Zfp36\) gene). DUSP1 is a negative feedback regulator of mitogen-activated protein kinases, TNFAIP3 negatively regulates the nuclear factor κB (NF-κB) signalling pathway and TTP is a destabiliser of pro-inflammatory mRNAs. All three FNGs were induced by pro-inflammatory stimuli, with very different dependence on NF-κB signalling. Further to this, the anti-inflammatory agonists dexamethasone, prostaglandin E\(_2\) (PGE\(_2\)) and transforming growth factor β (TGFβ) were able to impair NF-κB activity and yet cooperated with pro-inflammatory agonists to increase expression of all three FNGs. Experiments in primary mouse knock-out macrophages suggested that DUSP1 may be necessary for some anti-inflammatory effects of PGE\(_2\), and for the cooperative regulation of other FNGs by pro- and anti-inflammatory agonists. Three putative regulatory elements located upstream of the \(Zfp36\) locus were shown to mediate cooperative transcriptional regulation by various combinations of pro- and anti-inflammatory agonists. Chromatin immunoprecipitation experiments also demonstrated dynamic remodelling of the locus in response to a pro-inflammatory stimulus.
3
Müller, Jakub. "Protokol TTP pro správu hierarchických stromů zpětné vazby RTCP kanálu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217330.
Abstract:
TTP protocol for managing hierarchy trees of the RTCP feedback channel represents the mechanism for transferring the big amount of data from end users via the “narrow” feedback channel. We are not speaking about thousands of users but about millions of users, which are using services like IPTV. The method of a data summarization is used for this purpose in selected network nodes. The summarized message is transferred and summarized again in higher levels of the hierarchical tree. Both methods allow reducing the amount of data and help to increase information content transferred via the feedback channel. Finding of the correct end user position in a network is also very important aspect. The user must be able to find the closest summarization node with this information and starts sending out the messages to this node for processing. There are several methods for constructing and managing the asynchronous feedback channel that are introduced in this work.
4
Sebastiao, Elena. "Synthesis and Complexation of Nitrogen-rich Materials." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33162.
Abstract:
Nitrogen-rich materials are of increasing interests for the development of a wide variety of applications. These compounds are prime candidates for ligands used in the complexation of metals since they possess several lone pairs. Resulting complexes have also exhibited a wide variety of interesting properties, ranging from magnetism to gas absorption to energetic properties. This thesis describes the synthesis and characterisation of new metallic complexes with the known energetic ligands: hydrazine and H3bta, as well as that of a new nitrogen-rich compound: H4ttp. Chapter 2 outlines a series of chains bridged by hydrazine and their potential as initiatory compounds. Mononuclear lanthanide H3bta complexes are presented in Chapter 3. The development of the new nitrogen-rich, tetrazole-based H4ttp ligand is described in Chapter 4. This new ligand was used to synthesise various lanthanide complexes through hydrothermal reactions.
5
Perera, Cecilia Maria [Verfasser]. "Tierexperimentelle Untersuchungen zu Auslösefaktoren der Thrombotisch-thrombozytopenischen Purpura (TTP) / Cecilia Maria Perera." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1223379442/34.
6
Schaeffer, Gilbert Van. "Endothelial agonists stimulate VWF release in vitro and trigger TTP in vivo." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/5054.
Abstract:
Von Willebrand factor (VWF) is a plasma glycoprotein that can bind collagen at a wound site as well as circulating platelets. VWF forms high molecular weight multimers (>20,000 kDa). VWF can also form VWF strings that appear to be attached to the endothelial surface and are capable of binding platelets. These strings are only observed in vitro and in vivo in the absence of the VWF-cleaving protease ADAMTS13. Deficiency in ADAMTS13 results in thrombotic thrombocytopenic purpura (TTP), a clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, renal dysfunction, neurological dysfunction and fever. Patients suffering from TTP demonstrate VWF-and platelet-rich thrombi in the microvasculature of numerous organ systems, but most notably in the kidneys, heart, and brain. While VWF strings have not been directly connected to TTP, their presence in vivo was only identified with the ADAMTS13 knockout mouse (a model of TTP), suggesting a possible relationship.
Recently we identified glycerol as an agent, similar to histamine, that triggers the formation of VWF strings in vitro. We found that glycerol and histamine trigger TTP in an ADAMTS13-deficient mouse model. In addition, we determined conditions in vitro that promote the formation of dense VWF networks. These networks of VWF can be greater than 70 μm thick and appear to be able to form fibers as long as several millimeters in length. These networks have not been previously identified and may underlie a possible mechanism by which VWF-rich thrombi form in TTP. These networks were formed solely from cultured endothelial cells, leading us to believe that endothelial cells alone are capable of producing more VWF than perhaps previously appreciated. These data suggest that secretion of VWF from the endothelium may play an important role in the pathophysiology of TTP.
7
Buckley, Dave. "New Monitoring Paradigms for Modern Avionics Buses." International Foundation for Telemetering, 2013. http://hdl.handle.net/10150/579530.
Abstract:
ITC/USA 2013 Conference Proceedings / The Forty-Ninth Annual International Telemetering Conference and Technical Exhibition / October 21-24, 2013 / Bally's Hotel & Convention Center, Las Vegas, NVIn modern aircraft there is a proliferation of avionics buses. Some of these buses use industry wide standards such as ARINC 429 or AFDX while others are based on proprietary protocols. For many of the newer bus types there can be thousands of parameters on each bus. In a distributed data acquisition system the flight test engineer needs to record all of the data from each bus and monitor selected parameters in real time. There are numerous different approaches to acquiring, transmitting and recording data from avionics buses. In modern FTI there is also a proliferation of standards for recording and transmission including IRIG 106 Chapter 10, iNET and IENA. In this paper some common approaches to bus monitoring are compared and contrasted for popular buses such as ARINC 429, AFDX and Time Triggered Protocol. For each bus type the best approach is selected for reliable acquisition, speed of configuration, low latency telemetry and compact recording which is optimized for playback.
8
Alotaibi, Abdullah S. "Design and evaluate a fair exchange protocol based on online trusted third party (TTP)." Thesis, De Montfort University, 2012. http://hdl.handle.net/2086/7879.
Abstract:
One of the most crucial factors that e-commerce protocols should address is a fair exchange. In this research, an advanced method of cryptography coupled with the pay per use technique is used. A new electronic commerce protocol for the exchange of commodities is introduced. The proposed new protocol guarantees both features while addressing the main drawbacks associated with other related protocols. The new suggested e-commerce protocol is composed of two stages: pre-exchange and exchange stages. When the suggested new protocol is analysed with scrupulous protocol analysis, it attains fair exchange and a secure method of payment. The suggested new e-commerce protocol is more efficient than other related existing protocols. In this research “protocol prototype” and “model checking” is used for the purpose of authentication. The protocol prototype verifies that the suggested new protocol is executable when it's used in a real context. By experimental designs, this research shows the length of asymmetric keys as the biggest element that affects the efficiency of the protocol. When model-checking is applied in this protocol, the outcome indicates that the suggested protocol achieves the required features of fairness. Protocol extensions give those involved in the protocol the capacity to be resilient to failure. By using three methods of authentication, this research confirms that the new proposed protocol is well formulated. The work reported in this thesis first study the existing fair exchange protocols that solve the fairness problem. Then, propose more efficient protocol to solve the fairness problem. The original idea in this thesis is to reduce the communication overheads, risks and solve the bottleneck problems in the protocols that involve an online TTP.
9
Olivka, Petr. "Stabilita hierarchické agregace pro internetové televizní vysílání." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218806.
Abstract:
This work is about Hierarchical agregation and it describes its parts in the rst part of this work. Next is described its parts, main features and properties in this rst part. Document describes the possibilities of realization. Second part describes an analysis of the stability problem. Realizes the detection of failures of the Feedback target stations by the implemented protocol. The protocol is programaticly realized in JAVA language and tested in the real enviroment. In this document it is described an function of bandwidth on the speed of failure detection. The issues of detection of failure on the feedback target manager machine are discussed in this document.
10
Ebner, Katharina Julia [Verfasser]. "Untersuchungen zu Triggerfaktoren der thrombotisch thrombozytopenischen Purpura (TTP) in Mäusen / Katharina Julia Ebner." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/106906534X/34.
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Bastos, Moisés Pereira. "Comparação entre Protocolos TTP/C e flexray utilizando uma aplicação brake-by-wire." Instituto Tecnológico de Aeronáutica, 2010. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=1125.
Abstract:
O trabalho apresenta uma comparação entre protocolos de comunicação tolerantes a falha, TTP/C e Flexray, utilizando um simulador de tempo real, propondo modelar uma aplicação brake-by-wire tolerante a falhas que gere uma intensa troca de dados validando a comparação. O presente trabalho toma como base um modelo de um sistema de freio antitravamento (ABS - Antilock Brake System) para uma única roda, de Michaels e Quinn (1997), estendendo tal trabalho ao desenvolvimento de uma aplicação brake-by-wire, composta basicamente de 5 nós, sendo um controlador central e 4 nós locais apara as rodas do veículo. Após uma breve descrição introdutória sobre os conceitos básicos necessários para entender o projeto, a aplicação brake-by-wire será apresentada. Posteriormente serão apresentados conceitos de funcionamento da aplicação, tolerância a falha, controle de frenagem, entre outros. A modelagem e simulação do sistema foi realizada na ferramenta computacional TrueTime baseada no Matlab/Simulink, utilizando kernels de tempo real. A simulação demonstra os diferentes comportamentos da aplicação quando protocolos TTP/C e Flexray variam em largura de banda e taxa de utilização do barramento. Foi inserido um nó de interferência na rede, visando verificar o comportamento de tais protocolos com um trafego mais intenso na rede. Os resultados obtidos com a simulação de tempo real demonstram que o protocolo TTP/C apresentou um comportamento mais estável e seguro para tal aplicação considerada de tempo real crítico.
12
Rebert, Farzana [Verfasser]. "Beeinflussung der Vermehrungskinetik ausgewählter Krankheitserreger durch Antiseptika und Tissue Tolerable Plasma (TTP) / Farzana Rebert." Greifswald : Universitätsbibliothek Greifswald, 2014. http://d-nb.info/1051591171/34.
13
Fairhurst, Anna-Marie. "The role of the neutrophil FC receptor type 111b and tristetraprolin (TTP) in chronic inflammation." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400501.
14
Hochdörfer, Thomas [Verfasser]. "Evaluation of the influence of SHIP1-interacting proteins and TTP on mast cell signaling / Thomas Hochdörfer." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1037332504/34.
15
WANG, MIN. "Description and Application of Genetic Algorithm." Thesis, Blekinge Tekniska Högskola, Sektionen för ingenjörsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2362.
Abstract:
Genetic Algorithm (GA) as a class of Evolutionary Algorithm (EA) is a search algorithm based on the mechanics of natural selection and natural genetics. This dissertation presents the description, solving procedures and application of GA. The definitions of selection, crossover and mutation operators are given in details and an application based on GA in Time Table Problem (TTP) is performed in a new way. Due to its high capability of overall search, GA is particularly appropriate for solving timetabling and scheduling problems. TTP (Time Table Problem) which belongs to NP-hard problem is a special problem concerning resource management. In this dissertation, a new chromosome coding is designed in order to solve TTP more effectively. And the result presented by MATLAB will converge to a steady condition.
16
Vo, Ngoc Long. "Degradation mechanisms of TTP/TIS11 proteins, major effectors of the AU-rich element-mediated mRNA decay in eukaryotes." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209239.
Abstract:
Regulation of gene expression occurs at several levels in a cell. While control of transcription is often viewed as the main source of regulation, it is now clear that post-transcriptional processes are essential to fine-tune protein availability. The presence of AU-rich elements (ARE) in the 3’ untranslated region (3’UTR) of many important mRNAs exemplifies one such process. AREs alter the mRNA translation or degradation status by recruiting ARE-binding proteins (ARE-BP). ARE-BPs of the TTP/TIS11 family bind to their cognate ARE-RNAs using their conserved tandem zinc-finger domain and induce rapid decay of their targets. This allows for proper regulation of cell proliferation, cell death and inflammation. In this regard, TTP/TIS11 are main regulators of gene expression, and as such are put under strict transcriptional, post-transcriptional as well as several layers of post-translational control.In this work, we aimed at elucidating the degradation mechanisms affecting TTP/TIS11. Using Drosophila as a model, we found that dTIS11 protein turnover is rapid due to continuous degradation by the proteasome. However, proteasomal recognition did not require ubiquitination of dTIS11 as non-ubiquitinable mutants were efficiently degraded by the proteasome. In addition, dTIS11 was digested by the 20S proteasome that lacks ubiquitin-recognition domains. Our results further indicate that intrinsically disordered regions (IDR) in dTIS11 may be responsible for proteasomal recognition. In fact, dTIS11 is predicted as disordered and possesses the main characteristics of intrinsically disordered proteins (IDP). We also identified dTIS11 N- and C-terminal domains as functional signals for degradation, potentially due to their destructuration. This ubiquitination-independent, disorder-dependent degradation process is conserved throughout evolution as dTIS11 mammalian counterpart, TTP, undergoes the same degradation by default pathway. In addition, we established that phosphorylation prevents degradation of TTP/TIS11 by the proteasome.
Together, our results pinpoint a new essential characteristic for TTP/TIS11 that may redefine the identity of these proteins. In addition, we unraveled a novel and conserved mechanism of regulation of TTP/TIS11. This control is essential for cell physiology as defects in this process can lead to defects in the inflammatory response, increased radiation-induced lung toxicity and tumorigenesis.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
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Pereira, Aldo Santos. "Desenvolvimento de procedimento de reparo por soldagem em aços inoxidáveis martensíticos, com metal de adição similar sem TTP /." Florianópolis, SC, 2000. http://repositorio.ufsc.br/xmlui/handle/123456789/78770.
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Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Made available in DSpace on 2012-10-17T18:57:21Z (GMT). No. of bitstreams: 0Bitstream added on 2014-09-25T17:39:59Z : No. of bitstreams: 1 161165.pdf: 19353055 bytes, checksum: 6f8df058287e2ecf4d29718feb923e19 (MD5)
Este trabalho analisa a aplicabilidade de técnicas de soldagem de reparo sem tratamento térmico posterior (TTP) ao aço inoxidável martensítico macio tipo CA-6NM e, comparativamente, ao martensítico tradicional AISI 410. A soldabilidade do aço CA-6NM, com dois teores de C, foi avaliada através de análise da microestrutura, dureza e tenacidade do metal base e da ZAC simulada. Os resultados mostraram que, mantido baixo o teor de carbono (0,02%C), a técnica do revenimento por 3 passes TIG pode ser dispensável, como recurso para preservar as propriedades da união soldada. A análise de juntas soldadas pelo processo MIG pulsado, comparando o arame maciço AWS ER 410 NiMo e tubular AWS E410 NiMo-T2, mostrou que o reparo com metal de adição similar deve ser executado preferencialmente com arame maciço, que permite obter nível aceitável de tenacidade na solda sem TTP.
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Berady, Aïmad. "Comprendre les menaces sophistiquées : Intentions, moyens, manières et connaissances convergentes des adversaires." Thesis, CentraleSupélec, 2022. http://www.theses.fr/2022CSUP0004.
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Depuis quelques années, les experts du secteur de la cybersécurité observent une intensification d'attaques sophistiquées. Ces attaquants, qui agissent en profondeur, sont amenés à se propager dans les systèmes d'information de leurs victimes et à progresser furtivement vers leurs objectifs finaux. C'est pourquoi, des sondes doivent être disposées à des points stratégiques des systèmes d'information. Les entreprises ont également dû reconsidérer leurs mesures de cyberprotection, en mettant en place des systèmes centralisés de collecte de traces afin qu'elles puissent être exploitées dans l'éventualité d'une réponse à incident. Dans le cadre de cette thèse, les travaux que nous avons conduits ont permis de formaliser, d'un point de vue macroscopique, les différentes phases opérationnelles d'une campagne d'attaque. Parmi elles, celle de "propagation réseau" nous est apparue comme étant la plus pertinente pour détecter l'attaquant. En nous focalisant sur cette phase, nous avons ensuite mis en perspective les visions de l'attaquant et du défenseur dans le contexte d'une même campagne en confrontant leurs connaissances acquises au cours de leurs opérations respectives. Enfin, nous avons défini un modèle permettant une représentation de l'évolution de la connaissance de l'attaquant à propos du système d'information et de son espace de propagation. Ce modèle repose sur une sémantique, qui permet de spécifier formellement les techniques mises en œuvre par l'attaquant pour progresser vers ses objectifs finaux. Une expérimentation de grande envergure est venue renforcer cette contributionIn recent years, cybersecurity experts have observed an intensification of sophisticated threats. The attackers, acting in depth, are therefore led to propagate in their victim's information systems and progress stealthily toward their final objectives. Sensors must be deployed at strategic points in information systems. Companies also have had to reconsider their approaches to protect their information systems by setting up centralized systems to collect traces so that experts can exploit them if an incident occurs. In the context of this thesis, our work has made it possible to formalize the different operational phases of an attack campaign. Among them, "network propagation" appeared to be the most relevant for detecting the attacker. Then, we focused on this phase and put the visions of both the attacker and the defender into perspective. Finally, we defined a model allowing a representation of the attacker's propagation area and their knowledge evolution. This model wields semantics, allowing us to formally describe the techniques performed by the attacker to progress towards their final objectives. A large-scale experiment has reinforced this contribution
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Bosio, Eric Losala. "Os efeitos do acordo de associa??o transpac?fico (TTP) e do acordo de parceria transatl?ntico de com?rcio e investimento (TTIP) sobre o mercado internacional de fertilizantes." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2018. http://tede2.pucrs.br/tede2/handle/tede/8230.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
The present study aims to evaluate the possible impacts of eliminating tariff barriers on the fertilizer market. To evaluate the effects of free trade is used a spatial model formulated as Mixed Complementary Problem (MCP). To achieve the proposed objective, five scenarios are simulated: the first considers the elimination of tariff barriers in a multilateral arrangement; the second simulates the expansion of the Transatlantic Trade and Investment Partnership Agreement (TTIP), including Brazil in the agreement; the third simulates the inclusion of Brazil in the Trans-Pacific Association Agreement (TTP); the fourth simulates the formation of a bilateral agreement that eliminates trade barriers between Brazil and Russia; and the fifth simulates an agreement between Brazil and the region of Africa. The biggest gains are in the scenario where the elimination of all tariff barriers in a multilateral trade agreement is considered, which means that for the fertilizer market the elimination of tariff barriers in a multilateral trading arrangement is the best option for production for all producers than regional arrangements.
O presente estudo tem por objetivo avaliar os poss?veis impactos da elimina??o das barreiras tarif?rias sobre o mercado dos fertilizantes. A fim de avaliar os efeitos da liberaliza??o dos mercados, ? utilizado o modelo de equil?brio espacial formulado como um Problema de Complementaridade Mista (PCM). Para atingir o objetivo proposto s?o simulados cinco cen?rios: o primeiro considera a elimina??o das barreiras tarif?rias em um arranjo multilateral; o segundo simula a expans?o do Acordo de Parceria Transatl?ntico de Com?rcio e Investimento (TTIP), incluindo-se o Brasil no acordo; o terceiro simula a inclus?o do Brasil no Acordo de Associa??o Transpac?fico (TTP); o quarto simula a forma??o de um acordo bilateral que elimina as barreiras comerciais entre o Brasil e a R?ssia; e o quinto simula um acordo entre o Brasil e a regi?o da ?frica. Os maiores ganhos ocorrem no cen?rio em que se considera a elimina??o de todas as barreiras tarif?rias em um acordo comercial multilateral, o que permite dizer que, para o mercado de fertilizantes, a elimina??o das barreiras tarif?rias em um arranjo comercial multilateral ? a melhor op??o para impulsionar a produ??o para todos os produtores do que os arranjos regionais.
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Hammann, Aylin [Verfasser]. "Antiseptische Wirksamkeit von Tissue tolerable plasma (TTP) im Vergleich zu zwei Wundantiseptika an artifiziell bakteriell kontaminierten Augen von Schlachtschweinen / Aylin Hammann." Greifswald : Universitätsbibliothek Greifswald, 2013. http://d-nb.info/1033673749/34.
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Namazi, Majid. "Learning in Combinatorial Constraint Optimisation." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/419082.
Abstract:
Many real-world problems can be modelled as constraint optimisation problems (COPs). Each COP includes a set of variables with domains of values, constraints on the assignments to the variables, and an objective function, which should be minimised or maximised. In this thesis, we consider only combinatorial COPs, where domains of the variables are discrete. A component is a subproblem of a COP with specific variables, assignable values or constraints. Most practical COPs, including waste collection, mail delivery, supply chain management, and travelling thief problem (TTP), have more than one component. Existing methods for solving COPs, especially multi-component COPs, repeatedly solve the same problem or subproblem but do not take advantage of learning during the search. This research aimed to apply memorising and online or adaptive machine learning models. The memory buffers and the ML models are built, deployed, and updated during the search to improve search efficacy and efficiency in solving COPs, especially multi-component ones. In this research, we have developed a history memorising method to enhance diversity and effectiveness in solving COPs. Also, we have developed three online machine learning-based methods, one coordination learning for improving efficacy and two surrogate models for enhancing the efficiency of TTP solving. Our proposed solver, CoCo, is currently the state-of-the-art solver for solving TTP.
History memorising is an online low-level learning method to keep previously visited solutions or their objective values to avoid or escape from local optima during the search. The Late Acceptance Hill Climbing (LAHC) is a history memorising metaheuristic with promising performance on some COP domains. It aims to overcome the main downside of the traditional Hill Climbing (HC) search, which is often quickly trapped in a local optimum due to strictly accepting only non-worsening moves within each iteration. In contrast, LAHC also accepts worsening moves by keeping the objective values of the previously visited solutions in a limited-size circular memory. It compares the fitness values of candidate solutions against the least recent element in the circular memory to decide on accepting or rejecting them. However, we have realised that whenever all values in memory become the same, LAHC behaves like HC and gets stuck in local optima. We propose an improved form of LAHC called Diversified Late Acceptance Search (DLAS) for solving COPs in general, which usually uses much smaller memory, converges much faster than LAHC and escapes local optima much better than LAHC. The proposed DLAS approach outperforms LAHC on benchmark sets of Travelling Salesman Problem (TSP) and Quadratic Assignment Problem (QAP) instances.
TTP is an academic proxy for the waste collection and mail delivery real-world optimisation problems composed of TSP and Knapsack Problem (KP). In TTP, a thief makes a cyclic tour through a set of cities while collecting profitable items scattered over the cities into a rented capacitated knapsack. As the weight of the knapsack increases, the thief’s speed decreases; hence the renting cost increases. Solving TTP aims to maximise profit while minimising the renting cost simultaneously, which means maximising the difference between profit and renting cost. Existing TTP solvers typically employ interleaving and solve one component at a time while keeping the solution of the other component unchanged. This form of interleaving essentially means poor coordination in solving TTP. In this thesis, we first show that a simple local search based coordination approach does not work in TTP. Then, to adequately address interdependence between TSP and KP components, we propose a human-designed coordination heuristic that adjusts collection plans during the exploration of cyclic tours. We further propose another human-designed coordination heuristic that explicitly exploits the cyclic tours in selecting items during collection plan exploration. Lastly, we propose an online machine learning-based coordination heuristic that captures the characteristics of the two human-designed coordination heuristics while solving any TTP instance. Our proposed coordination-based approaches help our TTP solver, cooperative coordination (CoCo), significantly outperform existing state-of-the-art TTP solvers on a set of benchmark TTP instances.
Our proposed CoCo solver modifies a TTP instance’s underlying TSP and KP solutions in an iterative interleaved fashion. The TSP solution as a cyclic tour is typically changed in a deterministic way using the steepest-ascent Hill-Climbing (HC) search similar to other cooperative solvers. In contrast, changes to the KP solution typically involve a random HC search, effectively resulting in a quasi-meandering exploration of the TTP solution space. Once CoCo reaches a plateau, it restarts the iterative search of the TTP solution space by using a new initial cyclic tour. We have noticed that the final objective value remains almost the same if the same or similar initial cyclic tour is tried several times by CoCo or the other cooperative TTP solvers. Considering this semideterministic nature of the state-of-the-art cooperative TTP solvers, we propose two adaptive and online surrogate models to filter out non-promising initial cyclic tours to improve search efficiency. These surrogate models are automatically built, updated and deployed while solving any TTP instance. The first model is a Support Vector Regression (SVR)-based black-box model, and the second is a K Nearest Neighbour (KNN)-based white-box simulation model. Both models help to filter out non-promising initial cyclic tours while losing a small number of the cyclic tours leading to the best overall solutions. However, the KNN-based white-box simulation model is more accurate and efficient.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Info & Comm Tech
Science, Environment, Engineering and Technology
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Nóbrega, Luiz Henrique Melo Silva. "Desenvolvimento de uma estratégia de medição, baseada em nurbs, para determinação do desvio total de perfil (fα) de engrenagens cilíndricas de dentes retos usando MMCs." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/8961.
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For many years the power transmission and movement for gears has been an important technology in the automotive, mechanical and aeronautical industries, justifying the considerable number of research carried out under the quality control of these components. Nowadays, involute profile inspections of cylindrical gears have been carried out using CNC Coordinate Measuring Machines (CMMs) with rotary tables and dedicated measurement software, equipped with contact scanning sensors, Touch Trigger Probes – TTP or non-contact, Laser. However, many companies that manufacture and inspect gears use manual CMMs with point to point sensors, thus being unable to issue the profile deviation report. In respect, the motivation for this research is to develop and validate inspection strategies for determining the Total Profile Deviation (Fα) of spur gears, according to ISO 1328, using of a mathematical tool NURBS (Non-Uniform Rational B-Splines) and CMMs manual. Strategies for changing the NURBS weight parameter wi also were applied to assist in inspection definition procedure, and this is one more degree of freedom. In the first moment, before the execution of experimental procedures, simulations were carried out on a computational system and showed satisfactory results. For the experimental tests, a manual CMM MICRO-HITE 3D model was used with point to point sensor. Simulations and experimental results showed that the NURBS technique contributes to manual CMM application using Touch Trigger Probes in measuring the spur gears involute profile. The experimental results showed the methodology efficacy.
Por muitos anos a transmissão de movimento e de potência por engrenagens tem sido uma tecnologia importante nas indústrias automotiva, mecânica e aeronáutica, justificando assim a considerável quantidade de pesquisas realizadas no âmbito do controle de qualidade destes componentes. Atualmente, inspeções dos perfis evolventes de engrenagens cilíndricas vêm sendo realizadas utilizando Máquinas de Medição por Coordenadas (MMCs) CNC com mesas rotativas e softwares de medição dedicados, equipadas com sensores por contato de escaneamento, do tipo Touch Trigger Probe – TTP, ou sem contato, Laser. Porém, muitas empresas que fabricam e inspecionam engrenagens utilizam MMCs manuais com sensores do tipo ponto a ponto, ficando assim impossibilitadas de emitir o relatório de desvio de perfil. Neste sentido, a motivação para esta pesquisa é desenvolver e validar estratégias de inspeção para determinação do Desvio Total de Perfil (Fα) de engrenagens cilíndrica de dentes retos, segundo a norma ISO 1328, fazendo o uso da ferramenta matemática NURBS (Non – Uniform Rational B-Splines) e de MMCs manuais. Estratégias para alteração do parâmetro peso wi das NURBS também serão aplicadas para auxiliar na definição do procedimento de inspeção, sendo este um grau de liberdade a mais do modelo. No primeiro momento, antes da execução dos procedimentos experimentais, simulações foram realizadas em um sistema computacional, e apresentaram resultados satisfatórios. Para os testes experimentais foi utilizada uma MMC manual modelo MICRO-HITE 3D, com sensor do tipo ponto a ponto. Resultados de simulações e experimentais mostraram que a técnica NURBS contribui para aplicação de MMC manual usando sensor Touch Trigger na medição do perfil evolvente de engrenagens cilíndricas de dentes retos. Os resultados experimentais demonstraram a eficácia da metodologia desenvolvida.
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Pokludová, Michaela. "Lokalizace stanic u systému internetové televize." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218344.
Abstract:
This thesis deals with locating station in the digital television broadcast over the Internet Protocol. The aim of this thesis was to develop a general model for the location of stations in the system of internet TV. This work deals with the five known methods for locating stations in distributed systems, which compares as many criteria, such as coordinates of computation speed, accuracy of results. Based on the evaluation was selected optimal method, which has been incorporated into the simulation program IPTV and tested. The result of this work is the source code of the implemented methods.
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Frenzel, Laurent. "Régulations épigénétiques et rôles de la protéine Btk dans l'expression du TNF-α par la voie des TLRs." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01071591.
Abstract:
La Bruton tyrosine kinase ou Btk est une protéine dont le rôle dans la maturation des lymphocytes B est connu depuis plusieurs années. Par contre, son rôle dans le contrôle de l'immunité innée est moins établi. Nous avons montré que, en réponse à la voie des Toll like Receptors ou TLRs, Btk régule la stabilité de l'ARN messager du TNF-α par l'intermédiairede la protéine TTP ou Tristétraproline. Par ailleurs, nous avons montré que l'expression d'un microARN, le miR-346, régulait négativement la protéine Btk et donc la synthèse de TNF-α. L'amplification de l'expression de ce miR-346 par transfection permet d'avoir un effet anti-TNF-α et anti-Btk interessant notamment dans le modèle cellulaire de la polyarthrite rhumatoïde. Enfin, nous avons montré que, en réponse au TLRs, la modulation de l'expression du TNF-α en fonction de l'état de méthylation de l'ADN et d'acétylation des histones dépendait directement de l'expression du couple miR-346 et Btk. Btk est donc une protéine charnière dans le contrôle de l'inflammation par les mécanismes épigénétiques que sont les miARNs, la méthylation de l'ADN et l'acétylation des histones. Sur le plan thérapeutique, l'inhibition de cette protéine par ces différents mécanismes de régulation semble donc être très interessante, à la fois dans les maladies inflammatoires et néoplasiques.
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Degerman, Pär, and Niclas Wiker. "Analysis and Design of a Redundant X-by-Wire Control System Implemented on the Volvo Sirius 2001 Concept Car." Thesis, Linköping University, Department of Electrical Engineering, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1733.
Abstract:
The purpose of this master thesis project has been to analyze and document the Sirius 2001 Concept Car. In addition, it has also been a goal to get the car in a usable state by implementing new software on the on board computers.
The car is a Tiger Cat E1 that is modified with four wheel steering and an advanced X-by-Wire system. The computers in the X-by-Wire system consist of six TTP PowerNodes that communicate with each other over a redundant, fault tolerant TTP/C communications bus. The computers are connected to a number of sensors and actuators to be able to control the car.
This project has contributed to the car in several ways. A complete documentation of the systems implemented in the car is one. Another is a programmers manual which significantly lowers the threshold when working with the car. Last but not least is the modifications in hardware and software, which have made the car usable and show some of the possibilities with the system.
The results show that the Sirius 2001 Concept Car is a suitable platform for research in car dynamics and fault tolerant systems. The work has also shown that the TTP/C communication model works well in an application like this.
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Aravena, Muñoz Dayana. "Hacia una adecuada infraestructura nacional de la calidad en Chile." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/144315.
Abstract:
TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN POLÍTICAS PÚBLICASLa integración comercial ha avanzado a pasos agigantados, las barreras y dificultades comerciales son mínimas y los costos de traslado han disminuido. Las mejoras en la infraestructura física y económica, los desarrollos tecnológicos y en sistemas de información, mejores procesos de fabricación, transporte y otras mejoras que impactan directamente a las industrias y al comercio de productos y servicios, han generado un aumento acelerado del número de transacciones comerciales intra e inter mercados. Se han firmado tratados y convenios de comercio internacional y con ellos se han establecido reglas que enmarcan las relaciones comerciales como el Acuerdo sobre Obstáculos Técnicos al Comercio y el Acuerdo sobre la Aplicación de Medidas Sanitarias y Fitosanitarias, que cada miembro de la Organización Mundial de Comercio debe adscribir. Durante el 2016, se firmó el Acuerdo de Asociación Transpacífico (TTP) entre 12 países de América Latina y el Caribe (entre ellos Chile), América del Norte, Asia y Oceanía. EL TTP representa la mayor área de comercio medida como el PIB conjunto de sus integrantes y se caracteriza por tener una fuerte intención de armonización reglamentaria en áreas como el comercio electrónico, propiedad intelectual y cuidados medioambientales. Actualmente existe mucha incertidumbre respecto de su entrada en vigor por posibles efectos negativos sobre pequeños productores y también por conflictos políticos entre algunos miembros, no obstante, es un ejemplo de lo que significa la ganancia por mejora en las negociaciones y exportaciones de Chile (por ejemplo, agrícolas y agroindustriales) ante la presencia de acuerdos comerciales. Los potenciales beneficios de este y otros tratados, requieren de fuertes políticas industriales, tecnológicas y de innovación para dar respuesta a las exigencias internacionales. ¿Chile está preparado?. Los acuerdos comerciales se basan en la confianza y reconocimiento entre sus miembros. ¿Qué pasa si incumplimos los requisitos armonizados en la reglamentación? Podemos evaluar la respuesta mirando el caso de la exportación de salmón de Chile que excedió la cantidad de antibióticos permitida según los requisitos de ingreso de nuestro socio comercial Estados Unidos. El resultado fue la sustitución del mercado chileno por el mercado noruego y grandes pérdidas monetarias que se suman a la perdida de confianza en el aseguramiento de la calidad que brinda el país. Ejemplos como este, existen muchos en todas las regiones y en particular afectan principalmente a los países en desarrollo por su fuerte dependencia de la exportación de productos y servicios y las limitadas capacidades de establecer un sólido marco regulatorio e institucional que permita una mayor competitividad en el mercado internacional. Según la Organización para Cooperación y el Desarrollo Económico (OCDE, 1999), el 80% del comercio mundial total se ve afectado por normas y requisitos técnicos; y entre un 2% y 10% del costo total de producción se destinan a cumplir con las mismas (OCDE, 1996). Es decir que, si los países en vías de desarrollo buscan ingresar al mercado globalizado, deben poder contar con recursos relacionados al acceso a normas, capacidades de mediciones exactas, servicios de certificación y ensayos y acreditación. Todo esto es parte de lo que se llama Infraestructura de la Calidad. El crecimiento industrial sostenido ha sido motivo de creación de organizaciones que apoyen a los países en desarrollo o en transición para el fortalecimiento de las capacidades comerciales. En este contexto la Organización de las Naciones Unidas para el Desarrollo Industrial ha planificado y creado infraestructuras de la calidad donde no existían para maximizar las capacidades comerciales a nivel regional e internacional, movilizando conocimiento, destrezas, información y tecnología para apoyar el comercio y el desarrollo industrial. Se ha consensuado que la infraestructura de la calidad constituye un catalizador para la mejora de la calidad de los productos y servicios que se transan en los mercados y que, en consecuencia, ayuda a estimular la demanda de estos, lo que vigoriza negocios y la economía en general. Al contribuir con la industria nacional a satisfacer los requerimientos de los mercados de exportación, la infraestructura de la calidad aumenta la competitividad de la economía del país y su capacidad para participar en el comercio mundial y cadenas de valor, resguardando la seguridad del ciudadano y el medio ambiente. En síntesis, la infraestructura de la calidad entrega confianza al cliente y/o usuario cuando adquiere determinado bien o servicio. En adición, los servicios prestados por la infraestructura de la calidad, son grandes propulsores de nuevos avances sociales y tecnológicos, todos sus elementos ayudan a la sociedad y a la economía a hacer frente a distintos desafíos en un entorno cambiante, mediante la creación y difusión de nuevas tecnologías. Por ejemplo, para poder tener una comunicación eficiente se requiere de normas terminológicas para transferencia de conocimiento (normalización); o como el caso del sistema mundial de determinación de la posición (GPS) que se relaciona íntimamente con los avances en las esferas de la metrología científica; o bien cómo se han incorporado los sellos de rotulado energético a los electrodomésticos para orientar a la demanda a consumo eficiente de energía (acreditación y evaluación de la conformidad). En conexión con la relevancia de la IC en la estructura económica y la competitividad comercial, la incorporación de este tema en la agenda de discusión de política pública significa un gran avance en términos de la institucionalidad y marco regulatorio coherente y eficiente en sus iniciativas e interacciones. Este estudio constituye un esfuerzo de levantamiento de ideas, ciertas acciones y decisiones de política para el desafío de desarrollo de la Infraestructura Nacional de la Calidad chilena. Cabe mencionar que no se incorpora análisis econométrico, dada la escasa existencia de datos y a que el foco se mantuvo en generar un marco conceptual común para comenzar a generar conocimiento y literatura nacional sobre el tema. A su vez, esto se enlaza con un estudio previo de Evaluación del Impacto de la Infraestructura de la Calidad chilena en la Productividad1 solicitado por interés del Banco Interamericano de Desarrollo que levantó una serie de falencias respecto de lo que es en Chile una Infraestructura de la Calidad. El documento se divide en dos partes, en la primera se muestran las principales características de un modelo según las buenas prácticas internacionales y cómo se ha desarrollado en Chile. En ambos casos se abordan sus componentes, actores, institucionalidad, cifras de desempeño y otros, para cerrar posteriormente con una síntesis de impactos, beneficios y costos de la Infraestructura de la calidad en distintos ámbitos económicos y sociales. Luego, una segunda parte, enfrenta la discusión sobre las recomendaciones que acercarán a Chile hacia un correcto aseguramiento de la calidad, para lo cual en principio se compara el modelo según buenas prácticas con el existente a nivel nacional y luego se abordan los principales ámbitos de acción y decisión de política publica mediante recomendaciones.
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Pospíšil, Petr. "Optimalizace predikce pozice v síti." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217436.
Abstract:
This work is about position prediction in network, it is focused to find Landmark closest to the Host in the network (with lowest distance vector). The algorithm is based on GNP system. In terms of GNP system simulation was selected method for mathematical part of position prediction. The method was Simplex Downhill. The designed algorithm was implemented in Java. In the first step chose Host continent by meassuring the distance vector. In next step is selected nearest part in the continent. In conclusion estimate Host its position and then closest Landmark. Results from this work is important for designing TTP protocol. The verdict is that the GNP can be used for TTP, but Landmarks must be located in uniform density.
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Gilardin, Laurent. "Identification des épitopes T d’ADAMTS13 chez les patients atteints de Purpura Thrombotique Thrombocytopénique The ADAMTS13¹²³⁹-¹²⁵³ peptide is a dominant HLA-DR1-restricted CD4⁺ T-cell epitope Purpura Thrombotique Thrombocytopénique : physiopathologie, clinique, pronostic et traitement In silico calculated affinity of FVIII-derived peptides for HLA class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene In silico prediction of immuno-dominant T-cell epitopes on human therapeutic factor VIII Predictive immunogenicity of Refacto AF Complement C3 is a novel modulator of the anti-factor VIII immune response Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS520.
Abstract:
Le purpura thrombotique thrombocytopénique (PTT) est une maladie autoimmune rare et grave caractérisée par la présence d’anticorps dirigés contre ADAMTS13 (A13), une protéase impliquée dans l’hémostase primaire. L’implication des lymphocytes T CD4⁺ spécifiques d’ADAMTS13, dans la physiopathologie de la maladie est suggérée par une restriction pour l’haplotype HLA-DRB1*11 (DR11), l’isotype IgG des anticorps. Dans ce travail, nous avons cherché à identifier les épitopes T d’A13. Tout d’abord, nous avons sélectionné in silico les peptides d’A13 susceptibles d’être présentés par les molécules HLA-DR11. Ensuite, l’étude de la liaison de ces peptides à des molécules HLA-DR11 par des tests ELISA compétitifs a permis d’identifier les peptides les plus affins. Enfin, nous avons déterminé les peptides d’ADAMTS13 reconnus par les lymphocytes T CD4⁺ de donneurs sains et de patients porteurs de l’haplotype DR11. Ces travaux ont également été reproduits pour l’haplotype HLA-DR1 et dans un modèle murin de souris transgéniques humanisées exprimant l’haplotype HLA-DR1. Les résultats de ce travail nous permettent d’envisager d’isoler des lymphocytes T CD4⁺ spécifiques d’ADAMTS13 chez les patients afin de mieux les caractériser aux différents stades de la maladie et de suivre leur évolution sous traitement dans le but de mieux anticiper les rechutesThrombotic thrombocytopenic purpura (TTP) is a rare and severe disease characterized by auto-antibodies directed against ADAMTS13 (A13), a plasmatic protein involved in haemostasis. The implication of CD4⁺ T cells in the pathogenesis of the disease is suggested by the existence of a restriction to particular HLA-DR alleles and by the IgG isotype of the antibodies. In this study, we wished to determine the T cell epitopes of A13. First, we selected in silico the immunodominant peptides, based on their binding capacity to HLA-DR11 molecules. Second, their binding capacity to purified HLA-DR11 molecules using a ELISA competitive assay led us to identify the best binder peptides. Finally, we determined the peptides recognized by human CD4⁺ T cells from DR11 healthy donors and patients. These results were reproduced for the HLA-DR1 haplotype and in a transgenic humanized HLA-DR1 mouse model. In a perspective point of view, our results will allow us to further isolate the specific CD4⁺ T cells in order to characterize them at different steps of the disease and during follow-up to better anticipate relapses
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Le, Quilleuc Eloi. "Etude de la production de boson de Higgs en association avec une paire de quarks top-antitop dans l'expérience ATLAS." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS205/document.
Abstract:
J'ai pris part à la recherche du boson de Higgs dans l'expérience ATLAS avec l'étude de l'état final comprenant une paire de quark top anti-top accompagnée d'un boson de Higgs, dit ttH. Je me suis spécialisé sur le canal boostés, dans lequel quarks top et boson de Higgs sont émis à haute énergie.La mesure de la section efficace du processus physique pp -> ttH permet de tester la validité du Modèle Standard de la physique des particules, qui prédit le mécanisme d'interaction entre quark top et boson de HiggsI took part in the Higgs boson search in the ATLAS experiment with the study of the final state of a top anti-top quark pair accompanied by a Higgs boson, called ttH. I have been focused on the boosted channel, in which top quarks and Higgs bosons are emitted at high energy.The measurement of the cross-section of the physical process pp -> ttH enables to test the validity of the Standard Model of particle physics, which predicts the mechanism of interaction between quark top and Higgs boson
30
Maris, Frederic. "Planification SAT et Planification Temporellement Expressive. Les Systèmes TSP et TLP-GP." Phd thesis, Université Paul Sabatier - Toulouse III, 2009. http://tel.archives-ouvertes.fr/tel-00442014.
Abstract:
Cette thèse s'inscrit dans le cadre de la planification de tâches en intelligence artificielle. Après avoir introduit le domaine et les principaux algorithmes de planification dans le cadre classique, nous présentons un état de l'art de la planification SAT. Nous analysons en détail cette approche qui permet de bénéficier directement des améliorations apportées régulièrement aux solveurs SAT. Nous proposons de nouveaux codages qui intègrent une stratégie de moindre engagement en retardant le plus possible l'ordonnancement des actions. Nous présentons ensuite le système TSP que nous avons implémenté pour comparer équitablement les différents codages puis nous détaillons les résultats de nombreux tests expérimentaux qui démontrent la supériorité de nos codages par rapport aux codages existants. Nous présentons ensuite un état de l'art de la planification temporelle en analysant les algorithmes et l'expressivité de leurs langages de représentation. La très grande majorité de ces planificateurs ne permet pas de résoudre des problèmes réels pour lesquels la concurrence des actions est nécessaire. Nous détaillons alors les deux approches originales de notre système TLP-GP permettant de résoudre ce type de problèmes. Ces approches sont comparables à la planification SAT, une grande partie du travail de recherche étant déléguée à un solveur SMT. Nous proposons ensuite des extensions du langage de planification PDDL qui permettent une certaine prise en compte de l'incertitude, du choix, ou des transitions continues. Nous montrons enfin, grâce à une étude expérimentale, que nos algorithmes permettent de résoudre des problèmes réels nécessitant de nombreuses actions concurrentes.
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Maris, Frédéric. "Planification SAT et planification temporellement expressive : les systèmes TSP et TLP-GP." Toulouse 3, 2009. http://thesesups.ups-tlse.fr/688/.
Abstract:
Cette thèse s'inscrit dans le cadre de la planification de tâches en intelligence artificielle. Après avoir introduit le domaine et les principaux algorithmes de planification dans le cadre classique, nous présentons un état de l'art de la planification SAT. Nous analysons en détail cette approche qui permet de bénéficier directement des améliorations apportées régulièrement aux solveurs SAT. Nous proposons de nouveaux codages qui intègrent une stratégie de moindre engagement en retardant le plus possible l'ordonnancement des actions. Nous présentons ensuite le système TSP que nous avons implémenté pour comparer équitablement les différents codages puis nous détaillons les résultats de nombreux tests expérimentaux qui démontrent la supériorité de nos codages par rapport aux codages existants. Nous présentons ensuite un état de l'art de la planification temporelle en analysant les algorithmes et l'expressivité de leurs langages de représentation. La très grande majorité de ces planificateurs ne permet pas de résoudre des problèmes réels pour lesquels la concurrence des actions est nécessaire. Nous détaillons alors les deux approches originales de notre système TLP-GP permettant de résoudre ce type de problèmes. Ces approches sont comparables à la planification SAT, une grande partie du travail de recherche étant déléguée à un solveur SMT. Nous proposons ensuite des extensions du langage de planification PDDL qui permettent une certaine prise en compte de l'incertitude, du choix, ou des transitions continues. Nous montrons enfin, grâce à une étude expérimentale, que nos algorithmes permettent de résoudre des problèmes réels nécessitant de nombreuses actions concurrentesThis thesis deals with Artificial Intelligence planning. After introducing the domain and the main algorithms in the classical framework of planning, we present a state of the art of SAT planning. We analyse in detail this approach which allows us to benefit directly from improvements brought regularly to SAT solvers. We propose new encodings integrating a least-commitment strategy postponing as much as possible the scheduling of actions. We then introduce the TSP system which we have implemented to equitably compare the different encodings and we detail the results of numerous experimental tests which show the superiority of our encodings in comparison with the existing ones. We introduce then a state of the art of temporal planning by analysing algorithms and expressiveness of their representation languages. The great majority of these planners do not allow us to solve real problems for which the concurrency of actions is required. We then detail the two original approaches of our TLP-GP system which allow us to solve this type of problem. As with SAT planning, a large part of search work is delegated to a SMT solver. We then propose extensions of the PDDL planning language which allows us to a certain extent to take into account uncertainty, choice, or continuous transitions. We show finally, thanks to an experimental study, that our algorithms allow us to solve real problems requiring numerous concurrent actions
32
Qin, Yang. "Search for tt̄H production and measurement of the tt̄ cross-section with the ATLAS detector." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/search-for-tbarth-production-and-measurement-of-the-tbart-crosssection-with-the-atlas-detector(1c05f62c-67ad-4011-802d-703d045490f1).html.
Abstract:
The Higgs boson and the top quark have been a focus in modern elementary particle physics research because of their special roles in the Standard Model (SM) of particle physics. The studies of both particles are crucial for revealing the unsolved puzzles of modern particle physics. The coupling between the Higgs boson and the top quark, the top-Yukawa coupling, is one of the fundamental parameters in the SM that can potentially direct the future development of the theory of elementary particle physics. This thesis presents two analyses on the Higgs boson and the top quark, using proton-proton (pp) collision data collected by the ATLAS detector during 2012 and 2015. A search for the SM Higgs boson produced in association with a top quark pair (tt̄H) was performed using 20.3 fb⁻¹ of pp collision data at a centre-of-mass energy of √s = 8 TeV. The search is designed to be primarily sensitive to the H → bb decay mode. Events with one of two electrons or muons are used in the search. No significant excess of events is observed above the background predicted by the SM. An observed (expected) upper limit on the signal strength of 3.4 (2.2) times the SM prediction is obtained at 95% confidence level. The tt̄H signal strength, represented by the ratio of the measured tt̄H cross-section to the SM prediction, is found to be μ = 1.5 ± 1.1 for a Higgs boson mass of m_H = 125 GeV. A measurement of the top quark pair (tt̄) production cross-section was performed using 3.2 fb⁻¹ of pp collision data at √s = 13 TeV. The measurement uses events with an opposite-charge-sign electron-muon pair and exactly one and two jets originating from b quarks. The inclusive tt̄ production cross-section is measured to be σ_tt̄ = 818 ± 8(stat) ± 27(syst) ± 19(lumi) ± 12(beam) pb, where the uncertainties arise from data statistics, analysis systematic effects, the integrated luminosity and the LHC beam energy. The total relative uncertainty is 4.4%. The result is consistent with the theoretical prediction at the next-to-next-to-leading order accuracy in the strong coupling constant αs of QCD, with the resummation of next-to-next-to-leading logarithmic (NNLL) soft gluon terms. A fiducial cross-section corresponding to the experimental acceptance of leptons is also measured.
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SPAGNUOLO, GAIA. "MARCATORI MOLECOLARI AD IMPATTO TRASLAZIONALE NEL CARCINOMA EPATOCELLULARE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217460.
Abstract:
L’epatocarcinoma (EC) è un tumore maligno ad elevata morbilità e mortalità la cui speranza di cura è basata su diagnosi precoce e terapia individualizzata. Ad oggi il trattamento di elezione è rappresentato dalla chirurgia e l’unico farmaco con comprovata efficacia terapeutica è un presidio biologico di recente introduzione ad azione anti-tirosinochinasica (Sorafenib). La gestione ottimale del paziente con EC è sempre più influenzata dalla possibilità di disporre di marcatori molecolari da utilizzarsi nella pratica clinica a significato diagnostico, prognostico e predittivo. Il presente lavoro si propone come contributo all’identificazione e validazione di specifici indicatori biologici nella diagnostica del piccolo EC, predizione della recidiva del tumore resecato e della sensibilità individuale alla risposta al trattamento farmacologico nella forma avanzata.
E già stato dimostrato che l’accuratezza della diagnosi precoce di EC su biopsia epatica puo’ essere migliorata in maniera significativa dalla valuatazione dell’espressione combinata di alcuni marcatori recentmente proposti e già utilizzati nella pratica clinica. Abbiamo cercato di ottimizzare questo pannello valutando il contributo aggiuntivo della catena pesante della clatrina (CHC) che è componente essenziale nel sistema di trasporto vescicolare intra ed extracellulare, già segnalato come sovraregolato negli epatociti tumorali maligni. Utilizzando una casistica di EC di piccole dimensioni e di lesioni precancerose di controllo e documentando l’espressione della molecola con tecnica immunocitochimica, abbiamo verificato la sua efficacia in termini di accuratezza diagnostica. In particolare l’introduzione di CHC si è dimostrata in grado di incrementare la sensibilità del pannello dal 46,8% al 63,8% a fronte del mantenimento di una specificità assoluta.
E’ noto come il processo di carcinogenesi epatica origini anche sulla base di alterazioni delle vie molecolari che governano i processi di tipo ossidativo, con importante ruolo di protezione svolto dalla famiglia dei citocromi. Alcuni studi di espressione genica hanno già evidenziato che la recidiva di malattia tumorale nel fegato sia influenzata dalla disregolazione di alcuni citocromi, tra cui CYP1A2. Abbiamo inteso verificare e validare il ruolo del citocromo CYP1A2 nella qualità di possibile marcatore ad impatto traslazionale nella recidiva dell’EC attraverso il suo dosaggio immuncitochimico nel parenchima epatico non tumorale. Utilizzando una casistica omogenea di pazienti portatori di EC ad eziologia virale (virus C dell’epatite) e a follow-up noto, il dosaggio di CYP1A2 è risultato associato in maniera statisticamente significativa, sia in analisi univariata che multivariata al tempo libero da recidiva tumorale (p=0.012). In particolare la ridotta espressione del citocromo negli epatociti non tumorali, interpretabile come background più suscettibile alla trasformazione neoplastica “de novo”, risultava in grado di predire una più rapida ripresa della malattia.
La terapia farmacologica dell’EC è attualmente somministrata a pazienti portatori di forme avanzate senza tenere conto della reale e individuale suscettibilità all’azione del farmaco. Vi è una forte esigenza clinica di selezionare i pazienti candidabili al trattamento anche per gli elevati costi della terapia, ma nessun marcatore, sia esso tissutale o sierologico, si è rivelato ad oggi capace di soddisfare questi requisiti. Abbiamo inteso esplorare se i miRNA, che costituiscono una famiglia eterogenea ma fondamentale di molecole regolatrici della traduzione, potessero a loro volta candidarsi a possibili marcatori biologici di predizione della sensibilità al trattamento farmacologico dell’EC. A questo scopo, partendo da un pool amplissimo di miRNA, abbiamo proceduto ad una loro progressiva selezione sulla base della loro disregolazione nonchè associazione con il tempo di progressione della malattia dopo trattamento. Lo studio è stato condotto su biopsie epatiche pretrattamento di EC di pazienti omogeneamente trattati con Sorafenib. La selezione delle molecole e la validazione delle stesse è stata condotta in due casistiche distinte di cui la seconda utilizzata come coorte di validazione. Abbiamo cosi potuto individuare un unico miRNA con meccanismo di azione e geni targets poco conosciuti, il cui sovradosaggio valutato con tecnica di real-time PCR risultava fortemente e statisticamente associato ad una prolungata stabilizzazione della malattia tumorale (p=0.009).
L’insieme di questi risultati dimostra che la crescente domanda di marcatori di medicina personalizzata per ottimizzare la gestione del paziente oncologico (con EC nel nostro caso), possa essere soddisfatta attraverso l’applicazione di tecniche relativamente semplici e riproducibili quali l’immunocitochimica e l’analisi quantitativa del messaggero, condotte sia su tessuti tumorali che non tumorali. Naturalmente affinchè il dosaggio di una molecola possa entrare nella pratica clinica corrente, candidandosi come un autentico marcatore molecolare, è necessaria, come nei nostri casi, un’ulteriore validazione in studi di tipo prospettico.Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality worldwide. The treatment is based on early diagnosis and individualized therapy. Today surgery is the primary strategy for patients with HCC and Sorafenib, an anti tyrosine kinase drug, represents the only available drug with proven efficacy. The discovery of new molecular markers (diagnostic, prognostic and predictive) that can be translate in the clinical practice represents the improvement in the management of these patients. The present research is aimed at identifying and validating biological markers related to the early HCC diagnosis and to predict HCC relapse. In addition the individual sensibility to pharmacological treatment in patients with advanced HCC is also evaluated. It has been shown that the accuracy of the HCC early diagnosis on the liver biopsy can be significantly improved by combining histological features with molecular markers, recently proposed and applied in the clinical practice. We have optimized this molecular panel for evaluating the contribution of the clathrin heavy chain (CHC), which is an essential component of intra and extracellular vesicular transport, and previously reported as an up-regulated molecule in malignant liver cells. Using a series of small HCC and control precancerous lesions we tested, by immunohistochemical analysis, whether CHC expression contribute to improve the histopathological diagnostic accuracy. We found that the introduction of CHC increases the sensitivity from 46,8% to 63,8% and maintains an absolute specificity. It is now ascertained that hepatocarcinogenesis is based on alterations in a wide variety of molecular pathways controlling oxidative processes and that cytochromes family plays a protective role in this context. Additionally, gene expression profiles have shown that relapse of HCC is caused by some cytochromes deregulations (i.e. CYP1A2). We verified and validated the CYP1A2 role in relation to relapse of disease by immunohistochemistry and its quantification in non-tumoral liver parenchyma. By investigating a homogeneous series of HCC patients with HCV infection and known follow-up, we demonstrated that the CYP1A2 dosage was associated with the recurrence-free survival (p=0,012) in both univariate and multivariate analyses. Moreover, CYP1A2 expression decreased in non-tumoral hepatocytes, the most susceptible background to “de novo” neoplastic transformation, predicted a faster recurrence of disease. The pharmacological therapy of HCC is currently administered to patients with advanced disease, without any discrimination according to the individual drug susceptibility. There is a compelling clinical need to select patients more suitable to underwent pharmacological treatment, because of the elevated cost. Furthemore, there is no still histological and/or serological biomarker, capable to satisfy these requirements. For this reason, we explored whether miRNA, heterogeneous family of regulatory molecules of translation, can be used as new molecular predictive markers of sensitivity to HCC treatment. For this purpose, starting from a wide pool of miRNA, we progressively selected those deregulated and associated with time to progression of disease after treatment. This research was conducted on liver biopsies sampled before treatment in patients treated with Sorafenib. The selection and validation of miRNA were conducted on two distinct series of patients. Among these the second group of patients has been used as a validation set. We identified a single miRNA, with mechanism of action ad genes target unknown, which when appears overexpressed, by real-time PCR analysis, was strongly and statistically associated with prolonged stabilization of tumor disease (p=0,009). The above findings all suggest that the increasing demand for customized markers to optimized the management of HCC patients can be investigated through the application of relatively simple and reproducibly techniques (including immunohistochemistry and real-time PCR) on both tumoral and non-tumoral tissue. Further validation in prospective studies is required to pursue a personalized dosage of new molecular markers to be introduced in the current clinical practice.
34
Foti, Maria Giovanna. "Study of ttH production at sqrt(s) = 13 TeV in the all-jets channel with CMS." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13526/.
Abstract:
Measuring the associated production of the Higgs boson and a top quark-antiquark pair is one of the major goals for the Run 2 of the LHC. The aim of this thesis is to report on a first search for t ̄tH, using pp collision recorded with the CMS detector in the whole 2016, at a centre-of-mass energy of 13 TeV, and corresponding to an integrated luminosity L = 36 fb^−1. In particular, the analysis is performed and optimised on 2015
data, corresponding to an integrated luminosity L = 2.63 fb−1 , and then a projection of the results on the full data set is given. Candidate t ̄tH events are selected with criteria which enhance the all-jets decay channels of the t ̄t system and the decay of the Higgs boson into a bottom quark-antiquark pair (H -> bb). Despite being the channel with the highest branching ratio and potentially fully reconstructable, such decay mode is particularly challenging, due to the completely dominating background contributions.
In order to refine the selection, signal and background events are separated using a multivariate approach, using a Boosted Decision Tree. A first estimation of the BDT sensitivity is performed. Such estimate is presented as an upper limit at 95% confidence level on the t ̄tH production cross section, with respect to the SM expectations, through the signal strength (μ), and results in μ = 8.2^{+3.4}_{−2.4}. The projection of the result on the full data set is μ = 2.1^{+2.1}_{−1.6}.
35
Flowers, Sean Christopher. "Search for the Standard Model Higgs boson produced in association with top quarks in the lepton plus jets channel." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu150043192139632.
36
Gaber, Tarek. "Support consumers' rights in DRM : a secure and fair solution to digital license reselling over the Internet." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/support-consumers-rights-in-drm-a-secure-and-fair-solution-to-digital-license-reselling-over-the-internet(6b653587-36d3-4074-8578-5eaacdb68004).html.
Abstract:
Consumers of digital contents are empowered with numerous technologies allowing them to produce perfect copies of these contents and distribute them around the world with little or no cost. To prevent illegal copying and distribution, a technology called Digital Rights Management (DRM) is developed. With this technology, consumers are allowed to access digital contents only if they have purchased the corresponding licenses from license issuers. The problem, however, is that those consumers are not allowed to resell their own licenses- a restriction that goes against the first-sale doctrine. Enabling a consumer to buy a digital license directly from another consumer and allowing the two consumers to fairly exchange the license for a payment are still an open issue in DRM research area. This thesis investigates existing security solutions for achieving digital license reselling and analyses their strengths and weaknesses. The thesis then proposes a novel Reselling Deal Signing (RDS) protocol to achieve fairness in a license reselling. The idea of the protocol is to integrate the features of the concurrent signature scheme with functionalities of a License Issuer (LI). The security properties of this protocol is informally analysed and then formally verified using ATL logic and the model checker MOCHA. To assess its performance, a prototype of the RDS protocol has been developed and a comparison with related protocols has been conducted. The thesis also introduces two novel digital tokens a Reselling Permission (RP) token and a Multiple Reselling Permission (MRP) token. The RP and MRP tokens are used to show whether a given license is single and multiple resalable, respectively. Moreover, the thesis proposes two novel methods supporting fair and secure digital license reselling. The first method is the Reselling Deal (RD) method which allows a license to be resold once. This method makes use of the existing distribution infrastructure, RP, License Revocation List (LRL), and three protocols: RDS protocol RD Activation (RDA) protocol, and RD Completion (RDC) protocol. The second method is a Multiple License Reselling (MLR) method enabling one license to be resold N times by N consumers. The thesis presents two variants of the MLR method: RRP-MR (Repeated RP-based Multi-Reselling) and HC-MR (Hash Chain-based Multi-Reselling). The RRP-MR method is designed such that a buyer can choose to either continue or stop a multi-reselling of a license. Like the RD method, the RRP-MR method makes use of RP, LI, LRL, and the RDS, RDA, and RDC protocols to achieve fair and secure reselling. The HC-MR method allows multiple resellings while keeping the overhead on LI at a minimum level and enable a buyer to check how many times a license can be further resold. To do so, the HC-MR utilises MRP and the hash chain cryptographic primitive along with LRL, LI and the RDS, RDA and RDC protocols. The analysis and the evaluation of these three methods have been conducted. While supporting the license reselling, the two methods are designed to prevent a reseller from (1) continuing using a resold license, (2) reselling a non-resalable license, and (3) reselling one license a unauthorised number of times. In addition, they enable content owners of resold contents to trace a buyer who has violated any of the usage rights of a license bought from a reseller. Moreover, the methods enable a buyer to verify whether a license he is about to buy is legitimate for re-sale. Furthermore, the two methods support market power where a reseller can maximise his profit and a buyer can minimise his cost in a reselling process. In comparison with related works, our solution does not make use of any trusted hardware device, thus it is more cost-effective, while satisfying the interests of both resellers and buyers, and protecting the content owner's rights.
37
Ramírez, Sánchez Erika. "Diseño de un modelo de control de gestión para la unidad estratégica de negocio Tip Top Service." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137509.
Abstract:
Tesis para optar al grado de Magíster en Control de GestiónHoy, las empresas están compitiendo en entornos tan complejos llevándolas a reformular constantemente sus estrategias para aprovechar las oportunidades o disminuir amenazas y lograr ventajas competitivas que le generen la creación de valor sustentable a largo plazo para las partes interesadas. Para lograr este objetivo, los directivos deben planificar y gestionar la estrategia y ejecución operacional, labores fundamentales para lograr un alto desempeño. Sin embargo, en el día a día, los directivos destinan la mayor parte de sus recursos, a la gestión de las operaciones, quedando sin tiempo para revisar la eficacia de las estrategias. En consecuencia, se presentan brechas entre la planificación y ejecución, llevando a las empresas a fracasar en la implementación de las estrategias. A lo anterior, se suma que las causas de esta situación no son visibles para la administración, ya que las herramientas que utilizan para desarrollar la planificación y evaluar el desempeño, dificulta si la diferencia proviene de una planificación deficiente, una ejecución pobre, de ambas o de ninguna de ellas. El presente proyecto de grado, tiene por finalidad diseñar y proponer un modelo de control de gestión que relaciona el desarrollo y la planificación de la estrategia con la ejecución operacional, mediante la vinculación de diferentes herramientas de planificación y control de gestión, que permitan perfeccionar el desempeño de las empresas. Este modelo se aplicará a la unidad estratégica de negocio de Tip Top Service SpA, empresa dedicada a prestar servicios de mantenimiento de bandas transportadoras, empleadas por empresas del sector minero. El modelo aquí planteado, analiza las definiciones estratégicas de esta UEN, para lo cual se traza una propuesta de valor y el modelo de negocio necesarios para generar una ventaja competitiva perceptible por los clientes. También, se desarrolla un mapa estratégico que permita el perfeccionamiento de la propuesta de valor, a través de objetivos estratégicos claramente formulados y verificables. Además, se diseña un cuadro de mando integral, como los tableros de control, los cuales se vinculan con la gestión de sus empleados por medio del esquema de incentivos.
38
Cedeño, Rojas Maribel. "Arbeitsmittel und Arbeitsabläufe beim Übersetzen audiovisueller Medien Synchronisation und Untertitelung in Venezuela und in Deutschland." Trier Wiss. Verl. Trier, 2006. http://www.wvttrier.de/top/uebersetzwiss_r_programm.htm.
39
Hricko, Tomáš. "Laboratorní úlohy osvětlující princip síťových technologií a protokolů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-412989.
Abstract:
The aim of this diploma thesis is to create two exercises for students. The first exercise is concerned with comparison of transport protocols TCP and UDP. The second exercise is concerned with comparison of routing protocols OSPF and RIP. The first part describes used simulation environment. The next part describes the operating system used in routers. The following part describes the procedure of installing virtual machines. The next part consists of theory of protocols TCP, UDP, OSPF and RIP. The last two chapters are the laboratory exercises.
40
Díaz, Rodríguez Roxana. "Diseño de una herramienta de control de gestión para la empresa Rema Tip Top Latinoamerica SPA período 2016-2018." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137360.
Abstract:
Tesis para optar al grado de Magíster en Control de GestiónEl tema “DISEÑO DE HERRAMIENTAS DE CONTROL DE GESTIÓN PARA LA EMPRESA REMA TIP TOP LATINAMERICA SPA PERIODO 2016-2018”, consistió en hacer un análisis de los factores claves que intervienen en la planificación estratégica de la empresa, con el fin de establecer el rumbo a seguir para el periodo de estudio, generando un mapa estratégico que permita comunicar claramente la estrategia, explicando el modelo de negocios escogido para conseguir los objetivos, y desarrollando los tableros de gestión y control para las unidades que se requiere alinear, acompañados de los sistemas de incentivos para alinear el comportamiento de los colaboradores. Se comenzó desarrollando con la alta administración talleres para adaptar a la realidad local, la visión, misión y valores corporativos; así mismo se revisó los procesos operacionales del cliente objetivo, para determinar en qué parte de su cadena de valor, REMA TIP TOP LATINAMERICA encaja con los productos a necesitar por el cliente. Posteriormente se realizó varias jornadas para analizar los ámbitos interno y externo de la empresa; cada integrante del equipo desde su perspectiva funcional, aportó con su votación para establecer las principales fortalezas, oportunidades, debilidades y amenazas. Producto de los talleres de trabajo realizados con el grupo directivo, se desarrolló habilidades para la elaboración y ejecución exitosa del proceso de planificación en los futuros periodos. Tomando como base los objetivos estratégicos definidos durante el proceso, se creó tableros de gestión para dos de la Gerencia Comercial y la Gerencia de Operaciones que se requiere alinear y los tableros de control respectivos conformados por indicadores, metas, planes e iniciativas, generando en su mayoría documentación útil para el monitoreo del desempeño de los procesos de la organización en términos de lo que realmente es importante y que soporta el valor para el cliente. Finalmente para cada tablero de control se propuso un sistema de incentivos asociando cada objetivo a un incentivo diseñado específicamente para el grupo de empleados que trabajan en cada área, de tal forma que se motiven, formen parte del desarrollo de las iniciativas y colaboren activamente para llegar a las metas.
41
Rothkirch, Alyce von. "The place of Wales staging place in contemporary Welsh drama in English." Trier Wiss. Verl. Trier, 2007. http://www.wvttrier.de/top/Beschreibungen/MUSE.html.
42
Pietrzak-Franger, Monika. "The male body and masculinity representations of men in British visual culture of the 1990s." Trier Wiss. Verl. Trier, 2006. http://www.wvttrier.de/top/Beschreibungen/MUSE.html.
43
Wolff, Robert. "Searches for ttH and flavour-changing t –> Hq productions in multileptonic final states with the ATLAS detector." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0304/document.
Abstract:
Cette thèse de doctorat décrit la recherche de la production du boson de Higgs associée à une paire de quarks tops (tt̅H) dans un ensemble de données de collisions proton-proton à une énergie de centre de masse de √s = 13 TeV et avec une luminosité intégrée de 36,1 fb⁻¹, enregistrée par le détecteur ATLAS en 2015 et 2016. Sept états finaux, correspondants à différentes désintégrations du boson de Higgs, sont optimisés pour une meilleure séparation du signal par rapport au bruit de fond. Un excès d’événements par rapport au bruit de fond MS est observé avec une signification de 4,1 écarts types, tandis que 2,8 sont attendus. En combinaison avec des résultats de recherches avec d’autres canaux de désintégration du boson de Higgs, la production de tt̅H a été découverte par le détecteur ATLAS en utilisant jusqu’à 79,8 fb⁻¹ de données de collisions à √s = 7, 8 et 13 TeV.Les courants neutres, qui changent de saveur dans la désintégration du quark top en un boson de Higgs et un quark léger (t → Hq), sont fortement supprimés dans le MS. Des nouveaux modèles physiques peuvent prédire un rapport d’embranchement de t → Hc de 0,15%. La recherche de ces désintégrations, avec un état final à deux ou trois leptons, n’observe aucun signal. Une limite supérieure sur le ratio d’embranchement de t → Hc (t → Hu) avec un niveau de confiance de 95% est observé à 0,16% (0,19%) avec une limite attendue de 0,15% (0,15%).Pour contourner la limitation du nombre insuffisant des collisions, le LHC et ses expériences prévoient un plan de mise à niveau ambitieux. Un système de démonstration est en service depuis 2015 et ses performances étudiées avec des données de calibrations et de collisionsThis doctoral thesis describes the search for the associated Higgs boson production with a pair of top quarks (tt̅H) in a dataset of proton-proton collisions at a center-of-mass energy of √s = 13 TeV and with an integrated luminosity of 36.1 fb⁻¹, recorded by the ATLAS detector in 2015 and 2016. Seven final states, associated to different Higgs boson decay, are optimised to get the best signal to background separation. An excess of events over the SM background is observed with a significance of 4.1 standard deviations, while 2.8 are expected. In combination with search results obtained for other Higgs boson decay channels, the tt̅H production has been discovered with the ATLAS detector using up to 79.8 fb⁻¹ of collision data at √s = 7, 8 and 13 TeV.Flavour-changing neutral currents in top quark decays into a Higgs boson and a light up-type quark (t → Hq) are strongly suppressed in the SM. New physics models can predict a t → Hc decay branching ratio of 0.15%. The search for these decays in final states with two or three leptons observes no signal. An upper limit on the t → Hc (t → Hu) decay branching ratio at a 95% confidence level is set at 0.16% (0.19%) with an expected limit of 0.15% (0.15%).To bypass the limitation of an insufficient amount of collision data, the LHC and its experiments foresee an ambitious upgrade plan. The current ATLAS Liquid Argon Calorimeter readout will be replaced to get an increased granularity to improve the trigger selectivity and avoid bandwidth saturation at high luminosity. A demonstrator system has been operated since 2015 and its performance studied with calibration and collision data
44
Ballabene, Eric. "Characterisation of ttH production at 13 TeV in the multijet topologies with CMS." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19292/.
Abstract:
The associated production of a top quark pair with a Higgs boson (ttH) is very important because, in spite of its small production cross section, it enables the direct measurement of the Yukawa coupling of the Higgs boson to the top quark. The final states of ttH events depend on the specific decay of the top quarks and of the Higgs boson, and different topologies are originated, with or without energetic leptons in the final states. The events studied in this work correspond to an all-jet topology, with some of these jets which might be subject to boost given the large transverse momentum involved. It is therefore essential to classify the final states in terms of the number of "resolved" and "boosted" jets, and for each case different triggers are required. Since the background yields (mainly from top quark-antiquark pairs and QCD multijet production) are much larger than the expected signal, special care needs to be used to reduce them. The event selection is based on multivariate analysis algorithms which can distinguish signal from background events, and boosted jets associated to top quarks, to the Higgs bosons or to generic light quarks, enabling the definition of different event categories. The statistical performance of this analysis is characterised by two essential parameters, the upper limits on the signal strength and the signal significance. The expected upper limits on the signal strength are estimated at 95% confidence level, along with the signal significance, for each category and for the combination of all categories.
45
BONAM, VEERA VENKATA SIVARAMAKRISHNA. "Multipath TCP and Measuring end-to-end TCP Throughput : Multipath TCP Descriptions and Ways to Improve TCP Performance." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-17075.
Abstract:
Internet applications make use of the services provided by a transport protocol, such as TCP (a reliable, in-order stream protocol). We use this term Transport Service to mean the end-to- end service provided to application by the transport layer. That service can only be provided correctly if information about the intended usage is supplied from the application. The application may determine this information at the design time, compile time, or run time, and it may include guidance on whether a feature is required, a preference by the application, or something in between. Multipath TCP (MPTCP) adds the capability of using multiple paths to a regular TCP session. Even though it is designed to be totally backward compatible to applications. The data transport differs compared to regular TCP, and there are several additional degrees of freedom that the particular application may want to exploit. Multipath TCP is particularly useful in the context of wireless networks using both Wi-Fi and a mobile network is a typical use case. In addition to the gains in throughput from inverse multiplexing, links may be added or dropped as the user moves in or out of coverage without disrupting the end-to-end TCP connection. The problem of link handover is thus solved by abstraction in the transport layer, without any special mechanisms at the network or link level. Handover functionality can then be implemented at the endpoints without requiring special functionality in the sub-networks according to the Internet's end-to-end principle. Multipath TCP can balance a single TCP connection across multiple interfaces and reach very high throughput.
46
SANA, VINEESHA. "Multipath TCP and Measuring endto-end TCP Throughput : Measuring TCP Metrics and ways to improve TCP Throughput performance." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-17098.
Abstract:
Internet applications make use of the services provided by a transport protocol, such as TCP (a reliable, in-order stream protocol). We use the term Transport Service to mean the endtoend service provided to application by the transport layer. That service can only be provided correctly if information about the intended usage is supplied from the application. The application may determine this information at the design time, compile time, or run time, and it may include guidance on whether a feature is required, a preference by the application, or something in between. Multipath TCP (MPTCP) adds the capability of using multiple paths to a regular TCP session. Even though it is designed to be totally backward compatible to applications. The data transport differs compared to regular TCP, and there are several additional degrees of freedom that the particular application may want to exploit. Multipath TCP is particularly useful in the context of wireless networks using both Wi-Fi and a mobile network is a typical use case. In addition to the gains in throughput from inverse multiplexing, links may be added or dropped as the user moves in or out of coverage without disrupting the end-to-end TCP connection. The problem of link handover is thus solved by abstraction in the transport layer, without any special mechanisms at the network or link level. Handover functionality can then be implemented at the endpoints without requiring special functionality in the sub-networks according to the Internet's end-to-end principle. Multipath TCP can balance a single TCP connection across multiple interfaces and reach very high throughput.
47
Smith, Mark Anthony Shawn 1968. "Formal verification of TCP and T/TCP." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/42779.
Abstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (p. 421-424).
by Mark Anthony Shawn Smith.
Ph.D.
48
Chomont, Arthur. "Etude du couplage du quark top au boson de Higgs dans l'expérience ATLAS." Thesis, Université Clermont Auvergne (2017-2020), 2017. http://www.theses.fr/2017CLFAC082/document.
Abstract:
La découverte du boson de Higgs au LHC en 2012 est la plus récente confirmation de la validité du modèle standard, théorie décrivant les particules élémentaires et leurs interactions fondamentales. De nombreuses études ont été mises en place pour étudier les différentes caractéristiques de cette particule récemment découverte. Ce travail se concentre sur la recherche du processus ttH dans l’expérience ATLAS, pour réaliser une première mesure directe du couplage de Yukawa du boson de Higgs au quark top, paramètre important dans les modèles de physique au-delà du modèle standard. La première partie de ce travail a porté sur l’automatisation de l’étalonnage du calorimètre hadronique à tuiles du détecteur ATLAS (TileCal ) par un système laser. Une description de ce système qui permet un étalonnage régulier de toutes les cellules du calorimètre est tout d’abord présentée. Ensuite, l’algorithme d’automatisation de ce processus d’étalonnage, qui a été écrit lors de ce travail, est décrit. Le but final de cet algorithme est de faciliter et accélérer la correction des canaux dont le gain dérive. Une deuxième partie concerne la recherche du processus ttH par l’étude des états finals multi-leptons et particulièrement avec deux leptons de même charge électrique et au moins 4 jets dont 1 étiqueté b. L’estimation des bruits de fond instrumentaux et le traitement statistique réalisé sont décrits en détail dans le document pour deux versions de l’analyse. Une première version correspondant aux données de l’année 2015 et du début 2016, soit une luminosité intégrée de 13.2f b −1 de données, aboutit à une précision insuffisante pour conclure sur la présence du processus ttH. Une deuxième version de l’analyse, optimisée avec l’utilisation d’analyses multivariées sur l’ensemble des données 2015 et 2016, se conclut par une observation du processus ttH lors de la combinaison de l’ensemble des états finals ttH. La signification statistique observée est alors de 4.2σ pour une signification statistique attendue de 3.8σ. Ce résultat est donc en accord avec la prédiction du modèle standardDiscovery of Higgs boson at LHC in 2012 is the most recent confirmation of the validity of Standard Model, theory describing elementary particles and their interactions. Many analysis now target the extraction of properties of the newly-discovered particle. A direct measurement in the ATLAS experiment of the top Yukawa coupling, one of these properties, is targeted in this work through ttH process. This coupling is of particular interest because of its strong sensitivity to New Physics. The first part of the work is about the automation of the calibration of the hadronic tile calorimeter of the ATLAS detector. A detailed description of the laser system used for a regular calibration of the calorimeter is done as well as of the calibration itself. Then more details on the algorithm written for the automation of the calibration are given. The final goal of this algorithm is to ease and fasten the calibration of channels with gain variation. The second part is dedicated to the search for ttH process through multilepton final states with emphasis on final state with two same-sign leptons, at least four jets and at least 1 b-tagged jet. Estimation of reducible backgrounds and statistical treatment of the analysis are detailed. A first version of the analysis with 13.2f b −1 , corresponding to 2015 and mid-2016 LHC data, ends with a final precision too low to extract any conclusion on the tt̄H process. In a second version of the analysis, improvements are made using multivariate analysis and adding more signal regions. The results from the multilepton analysis is combined with results from other ttH analysis, targeting other Higgs decays, to attain a final observed sentivity of 4.2σ. Thus an evidence for ttH production can be claimed from this combination. The final results give good agreement with Standard Model prediction
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Raine, John. "Evidence for the production of a Higgs boson in association with two top quarks with the ATLAS detector." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/evidence-for-the-production-of-a-higgs-boson-in-association-with-two-top-quarks-with-the-atlas-detector(8c0c9d01-ee21-4f7e-9db6-1f5d92de1faf).html.
Abstract:
In this thesis, the search for the production of the Higgs boson in associationwith two top quarks is presented. The main focus of this work is on the analysis optimised for the decay of the Higgs boson to a b-quark pair. The analysis is performed using 36.1 fbâ1 of ppcollision data at a centre of mass energy sqrt(s)=13 TeV collected by the ATLAS detector at the Large Hadron Collider during 2015 and 2016. The signal strength of ttH in relation to the Standard Model prediction for a Higgs boson with a mass of 125 GeV is measured to be mu(ttH) = 0.87 +0.64â0.61, with signal strengths greater than 2.0 excluded at the 95% confidence level. The combination of this analysis with searches targeting additional Higgs boson decay modes is subsequently presented. The measured signal strength in relation to the Standard Model prediction is mu(ttH) = 1.2 +/-0.3. This correspondsto an observed (expected) significance for ttH of 4.2sigma (3.8sigma), constituting evidence for the ttH production mode. Finally, a study into the ability to observe and model the colour connection of b-quarks in ttH(bb) and ttbar+jets events is presented. The jet pull angle observable is used to investigate the effect of colour connection on jet substructure. Such an observable is found to be sensitive to the underlying colour structure in events, showing differences between b-quarks which decay from a colour singlet in comparison to a colour octet. However, the effect is found to be small and a larger dataset is required to measure the effect in ttH events.
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Baudry, Antoine. "Analyse fonctionnelle des protéines TT2, TT8 et TTG1 : étude de leur rôle dans la régulation de la biosynthèse des flavoni͏̈des chez Arabidopsis thaliana." Paris 11, 2004. http://www.theses.fr/2004PA112137.
Abstract:
Au cours du développement de la graine d'Arabidopsis thaliana, les proanthocyanidines (PA) s'accumulent spécifiquement dans la couche la plus interne des téguments de la graine. Il a été montré précédemment que TT2 et TT8 codent, respectivement, pour des facteurs de transcription à domaine MYB et bHLH, impliqués dans la régulation du métabolisme des PA. Avec TTG1, une protéine à domaine WDR, ces facteurs régulent l'expression d'un gène codant pour une enzyme clé de la biosynthèse des PA : BANYULS (BAN). Nous avons étudié les interactions entre TT2, TT8, TTG1 et le promoteur de BAN. Les premiers résultats obtenus en utilisant des protéines de fusion avec le récepteur aux glucocorticoi͏̈des (GR) suggèrent fortement que TT2, TT8 et TTG1 peuvent activer directement l'expression de BAN. Des expériences de double-hybride ont démontré que ces protéines peuvent former un complexe stable. L'expression simultanée de TT2 et TT8 dans la levure s'est révélée suffisante pour permettre une liaison au promoteur de BAN, même si l'activité de ce complexe est corrélée au niveau d'expression de TTG1 chez A. Thaliana. Des expériences d'expression transitoire en protoplastes ont montré que TTG1 agit principalement par la régulation de l'activité du partenaire bHLH et que TT2 ne peut pas être remplacé par les MYB les plus proches d'A. Thaliana pour activer BAN. En accord avec ces résultats, l'expression ectopique de TT2 a été suffisante pour déclencher l'activation de BAN dans les parties végétatives, mais uniquement où TTG1 est exprimé. L'ensemble de ces résultats indique que TT2, TT8 et TTG1 forment un complexe contrôlant directement l'expression de BAN in plantaDuring Arabidopsis thaliana seed development, proanthocyanidins accumulate specifically in the most inner cell layer of the seed coat. Previous results have demonstrated that TT2 and TT8 encode an R2R3-MYB and a bHLH transcription factors involved in the regulation of PA metabolism, respectively. Together with TTG1, a WD-Repeat protein, these factors regulate the expression of the gene encoding a core enzyme of PA biosynthesis: BANYULS (BAN). We investigated the interplays between TT2, TT8, TTG1 and the BAN promoter. Results obtained using chimeric protein with the Glucocorticoid Receptor (GR) in planta strongly suggested that TT2, TT8, and TTG1 can directly activate BAN expression. Experiments using yeast two- and three-hybrid clearly demonstrated that TT2, TT8, and TTG1 can form a stable ternary complex. Furthermore, although TT2 and TT8 were able to bind to the BAN promoter when simultaneously expressed in yeast, the activity of the complex correlated with the level of TTG1 expression in A. Thaliana. In addition, transient expression experiments revealed that TTG1 acts mainly through the bHLH partner (i. E. TT8, GL3 or EGL3) and that TT2 cannot be replaced by any other related A. Thaliana MYB protein (e. G. PAP1) to activate BAN. Consistently with these results, the ectopic expression of TT2 was sufficient to trigger BAN activation in vegetative parts of the plant, but only where TTG1 is expressed. Taken together, these results indicated that TT2, TT8, and TTG1 can form a ternary complex directly regulating BAN expression in planta