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Journal articles on the topic 'TUBA4A'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Van Schoor, Evelien, Mathieu Vandenbulcke, Valérie Bercier, et al. "Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology." Biomolecules 12, no. 3 (2022): 440. http://dx.doi.org/10.3390/biom12030440.

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Recently, disease-associated variants of the TUBA4A gene were identified in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we present the neuropathological report of a patient with the semantic variant of primary progressive aphasia with a family history of Parkinsonism, harboring a novel frameshift mutation c.187del (p.Arg64Glyfs*90) in TUBA4A. Immunohistochemistry showed abundant TAR DNA-binding protein 43 kDa (TDP-43) dystrophic neurite pathology in the frontal and temporal cortex and the dentate gyrus of the hippocampus, consistent with frontotem

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2

Mol, Merel O., Tsz H. Wong, Shamiram Melhem, et al. "Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia." Neurology Genetics 7, no. 3 (2021): e596. http://dx.doi.org/10.1212/nxg.0000000000000596.

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ObjectiveDespite the strong genetic component of frontotemporal dementia (FTD), a substantial proportion of patients remain genetically unresolved. We performed an in-depth study of a family with an autosomal dominant form of FTD to investigate the underlying genetic cause.MethodsFollowing clinical and pathologic characterization of the family, genetic studies included haplotype sharing analysis and exome sequencing. Subsequently, we performed immunohistochemistry, immunoblotting, and a microtubule repolymerization assay to investigate the potential impact of the candidate variant in tubulin a

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Quelhas, Patrícia, Rui Oliveira, Carlos Kieling, Sandra Vieira, and Jorge dos Santos. "Structural Disruption of Cilia and Increased Cytoplasmic Tubulin in Biliary Atresia—An Exploratory Study Focusing on Early Postoperative Prognosis Following Portoenterostomy." Biomedicines 13, no. 1 (2025): 87. https://doi.org/10.3390/biomedicines13010087.

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Introduction: Biliary atresia (BA) is a progressive hepatobiliary disease in infants, leading to liver failure and the need for transplantation. While its etiopathogenesis remains unclear, recent studies suggest primary cilia (PC) disruption plays a role. This study investigates correlations between PC and cytoplasmic tubulin (TUBA4A) alterations with hypoxia in patients with the isolated form of BA, focusing on native liver survival. Methods: Using qualitative and quantitative digital image analysis of immunofluorescence-stained liver samples, we assessed PC and TUBA4A features correlating th

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Рушкевич, Ю. Н., Е. В. Мальгина, С. А. Лихачев, and И. А. Петрович. "Hereditary Neuromuscular Disease, Probably Caused by a Mutation in the TUBA4A Gene c.1049G>T (p. Gly350Val): Own Clinical Observation." Неврология и нейрохирургия. Восточная Европа 14, no. 2 (2024): 282–90. http://dx.doi.org/10.34883/pi.2024.14.2.055.

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В настоящем исследовании представлено описание собственного клинического случая наследственного нервно-мышечного заболевания, вероятно обусловленного мутацией в гене TUBA4A. Данный ген повсеместно экспрессируется в тканях человека, наиболее высокая экспрессия наблюдается в головном мозге. Преобладающим фенотипом у носителей мутации TUBA4A является боковой амиотрофический склероз, однако в нескольких случаях у пациентов была диагностирована врожденная миопатия, лобно-височная деменция, нигропатия с паркинсонизмом. Выявленная у пациентки патогенная мутация в гене TUBA4A является de novo и характ

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Soloveva, Natalia, Svetlana Novikova, Tatiana Farafonova, Olga Tikhonova, and Victor Zgoda. "Proteomic Signature of Extracellular Vesicles Associated with Colorectal Cancer." Molecules 28, no. 10 (2023): 4227. http://dx.doi.org/10.3390/molecules28104227.

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The proteins of extracellular vesicles (EVs) provide proteomic signatures that reflect molecular features of EV-producing cells, including cancer cells. Detection of cancer cell EV proteins is of great interest due to the development of novel predictive diagnostic approaches. Using targeted mass spectrometry with stable-isotope-labeled peptide standards (SIS), we measured in this study the levels of 34 EV-associated proteins in vesicles and whole lysate derived from the colorectal cancer (CRC) cell lines Caco-2, HT29 and HCT116. We also evaluated the abundance of 13 EV-associated proteins (FN1

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Li, Jiao, Ji He, Lu Tang, Lu Chen, Yan Ma, and Dongsheng Fan. "Screening for TUBA4A mutations in a large Chinese cohort of patients with ALS: re-evaluating the pathogenesis of TUBA4A in ALS." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 12 (2018): 1350–52. http://dx.doi.org/10.1136/jnnp-2017-317560.

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7

Dols-Icardo, Oriol, Oriol Iborra, Jessica Valdivia, et al. "Assessing the role of TUBA4A gene in frontotemporal degeneration." Neurobiology of Aging 38 (February 2016): 215.e13–215.e14. http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.030.

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8

Novikova, Svetlana E., Natalia A. Soloveva, Tatiana E. Farafonova, Olga V. Tikhonova, Pao-Chi Liao, and Victor G. Zgoda. "Proteomic Signature of Extracellular Vesicles for Lung Cancer Recognition." Molecules 26, no. 20 (2021): 6145. http://dx.doi.org/10.3390/molecules26206145.

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The proteins of extracellular vesicles (EVs) that originate from tumors reflect the producer cells’ proteomes and can be detected in biological fluids. Thus, EVs provide proteomic signatures that are of great interest for screening and predictive cancer diagnostics. By applying targeted mass spectrometry with stable isotope-labeled peptide standards, we assessed the levels of 28 EV-associated proteins, including the conventional exosome markers CD9, CD63, CD81, CD82, and HSPA8, in vesicles derived from the lung cancer cell lines NCI-H23 and A549. Furthermore, we evaluated the detectability of

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9

Rademakers, Rosa, and Marka van Blitterswijk. "Excess of Rare Damaging TUBA4A Variants Suggests Cytoskeletal Defects in ALS." Neuron 84, no. 2 (2014): 241–43. http://dx.doi.org/10.1016/j.neuron.2014.10.002.

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10

Li, Jiao, Ji He, Lu Tang, et al. "TUBA4A may not be a significant genetic factor in Chinese ALS patients." Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 17, no. 1-2 (2015): 148–50. http://dx.doi.org/10.3109/21678421.2015.1074705.

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11

Smith, Bradley N., Nicola Ticozzi, Claudia Fallini, et al. "Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS." Neuron 84, no. 2 (2014): 324–31. http://dx.doi.org/10.1016/j.neuron.2014.09.027.

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12

Pensato, Viviana, Cinzia Tiloca, Lucia Corrado, et al. "TUBA4A gene analysis in sporadic amyotrophic lateral sclerosis: identification of novel mutations." Journal of Neurology 262, no. 5 (2015): 1376–78. http://dx.doi.org/10.1007/s00415-015-7739-y.

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13

Li, Hanwen, Shaohua Chen, and Hua Mi. "A Multiomics Profiling Based on Online Database Revealed Prognostic Biomarkers of BLCA." BioMed Research International 2022 (May 25, 2022): 1–19. http://dx.doi.org/10.1155/2022/2449449.

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Background. Bladder cancer (BLCA) is one of the most common urological malignancies globally, posing a severe threat to public health. In combination with protein-protein interaction (PPI) network analysis of proteomics, Gene Set Variation Analysis (GSVA) and “CancerSubtypes” package of R software for transcriptomics can help identify biomarkers related to BLCA prognosis. This will have significant implications for prevention and treatment. Method. BLCA data were downloaded from The Cancer Genome Atlas (TCGA) database and GEO database (GSE13507). GSVA analysis converted the gene expression mat

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Fenton, Christopher G., Hagar Taman, Jon Florholmen, Sveinung W. Sørbye, and Ruth H. Paulssen. "Transcriptional Signatures That Define Ulcerative Colitis in Remission." Inflammatory Bowel Diseases 27, no. 1 (2020): 94–105. http://dx.doi.org/10.1093/ibd/izaa075.

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Abstract Background This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was investigated by applying the next-generation technology RNA-Seq. Methods Mucosal biopsies from patients in remission (n = 14), patients with active UC (n = 14), and healthy control patientss (n = 16) unde

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15

Helferich, Anika M., Sarah J. Brockmann, Jörg Reinders, et al. "Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS." Cellular and Molecular Life Sciences 75, no. 23 (2018): 4301–19. http://dx.doi.org/10.1007/s00018-018-2873-1.

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16

Sater, Ali H. Abdel, Yihui Chen, Johannes F. Fahrmann, et al. "Abstract 2017: A liquid biopsy approach to gastric cancer reveals a signature reflective of epithelial to mesenchymal transition." Cancer Research 83, no. 7_Supplement (2023): 2017. http://dx.doi.org/10.1158/1538-7445.am2023-2017.

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Abstract Comprehensive proteomic profiling of plasmas collected before and after neo-adjuvant treatment for gastric cancer (GC) yielded 522 proteins exhibiting higher pre-treatment levels compared to healthy controls and among them, 345 proteins decreased after the treatment. Increased levels of cytoskeleton-related proteins were manifest in the plasmas of GC patients. Cytoskeletal proteins are known to play integral roles in modulating epithelial plasticity by altering mechanical strength and structural design that is critical for cancer cell motility, epithelial to mesenchymal transition (EM

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17

Perrone, Federica, Hung Phuoc Nguyen, Sara Van Mossevelde, et al. "Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients." Neurobiology of Aging 51 (March 2017): 177.e9–177.e16. http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.008.

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18

Matthews, K. A., D. Rees, and T. C. Kaufman. "A functionally specialized alpha-tubulin is required for oocyte meiosis and cleavage mitoses in Drosophila." Development 117, no. 3 (1993): 977–91. http://dx.doi.org/10.1242/dev.117.3.977.

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Three alpha-tubulin proteins contribute to microtubules during oogenesis and early embryogenesis in Drosophila melanogaster: alpha TUB84B, alpha TUB84D, and alpha TUB67C. alpha TUB67C is unique in two respects. It is a structurally divergent alpha-tubulin, sharing only 67% amino acid identity with the generic isotypes alpha TUB84B and alpha TUB84D, and its expression is exclusively maternal. The genetic analysis of the alpha Tub67C gene described here demonstrates that alpha TUB67C is required for nuclear division in the oocyte and early embryo. Both meiosis and cleavage-stage mitoses are seve

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19

Kononikhin, Alexey, Alexander Brzhozovskiy, Anna Ryabokon, et al. "Proteome Profiling of the Exhaled Breath Condensate after Long-Term Spaceflights." International Journal of Molecular Sciences 20, no. 18 (2019): 4518. http://dx.doi.org/10.3390/ijms20184518.

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Comprehensive studies of the effects of prolonged exposure to space conditions and the overload experienced during landing on physiological and biochemical changes in the human body are extremely important in the context of planning long-distance space flights, which can be associated with constant overloads and various risk factors for significant physiological changes. Exhaled breath condensate (EBC) can be considered as a valuable subject for monitoring physiological changes and is more suitable for long-term storage than traditional monitoring subjects such as blood and urine. Herein, the

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20

Karofi, Isah Abubakar, Abdulrahman Ado та Muntari Lawal. "Tarken Tubalan Gina Jigon Gargaɗi a Waƙar ‘Korona Biros’ ta Abdullahi Abubakar Lamiɗo". Dunɗaye Journal of Hausa Studies 3, № 01 (2024): 280–88. http://dx.doi.org/10.36349/djhs.2024.v03i01.034.

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Rubutacciyar waƙa saƙo ne wanda aka gina shi a kan tsari mai ƙa’ida ta baiti, ɗango, kari, amsa-amo da rerawa da daidaita kalmomi da zaɓen su da amfani da su cikin sigogin da ba lalle ne haka suke a maganar baka ba. Don haka, marubuta waƙoƙin Hausa na tsara waƙoƙinsu domin su isar da saƙonninsu a kan fannoni daban-daban ta hanyar amfani da wasu tubala waɗanda za su taimaka masu wajen cim ma saƙon da suke son isarwa ga jama’a. Wannan takarda ta fito da yadda Abdullahi Abubakar Lamiɗo ya yi amfani da wasu tubala wajen tsara saƙon da waƙarsa take son isarwa ga masu karatu. An yi amfani da salon n

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21

Liu, Siyu, Chenyang Hu, Yueqiu Luo, and Ke Yao. "Genome-wide DNA methylation profiles may reveal new possible epigenetic pathogenesis of sporadic congenital cataract." Epigenomics 12, no. 9 (2020): 771–88. http://dx.doi.org/10.2217/epi-2019-0254.

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Aim: To investigate the possible epigenetic pathogenesis of sporadic congenital cataract. Materials & methods: We conducted whole genome bisulfite sequencing on peripheral blood from sporadic binocular or monocular congenital cataract patients and cataract-free participants. Results: We found massive differentially methylated regions within the whole genomes between any two groups. Meanwhile, we identified five genes ( ACTN4, ACTG1, TUBA1A, TUBA1C, TUBB4B) for the binocular and control groups and TUBA1A for the monocular and control groups as the core differentially methylated region-relat

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Plumel, Marine, Stéphanie Dumont, Pauline Maes, et al. "Circadian Analysis of the Mouse Cerebellum Proteome." International Journal of Molecular Sciences 20, no. 8 (2019): 1852. http://dx.doi.org/10.3390/ijms20081852.

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The cerebellum contains a circadian clock, generating internal temporal signals. The daily oscillations of cerebellar proteins were investigated in mice using a large-scale two-dimensional difference in gel electrophoresis (2D-DIGE). Analysis of 2D-DIGE gels highlighted the rhythmic variation in the intensity of 27/588 protein spots (5%) over 24 h based on cosinor regression. Notably, the rhythmic expression of most abundant cerebellar proteins was clustered in two main phases (i.e., midday and midnight), leading to bimodal distribution. Only six proteins identified here to be rhythmic in the

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Soloveva, Natalia, Svetlana Novikova, Tatiana Farafonova, Olga Tikhonova, and Victor Zgoda. "Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer." International Journal of Molecular Sciences 26, no. 3 (2025): 1016. https://doi.org/10.3390/ijms26031016.

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Colorectal cancer (CRC) and lung cancer (LC) are leading causes of cancer-related mortality, highlighting the need for minimally invasive diagnostic, prognostic, and predictive markers for these cancers. Proteins secreted by a tumor into the extracellular space directly, known as the tumor secretome, as well as proteins in the extra-cellular vesicles (EVs), represent an attractive source of biomarkers for CRC and LC. We performed proteomic analyses on secretome and EV samples from LC (A549, NCI-H23, NCI-H460) and CRC (Caco2, HCT116, HT-29) cell lines and targeted mass spectrometry on EVs from

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Fatoki, Toluwase Hezekiah, Stanley Chukwuejim, Chibuike C. Udenigwe, and Rotimi E. Aluko. "In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis." International Journal of Molecular Sciences 24, no. 6 (2023): 5828. http://dx.doi.org/10.3390/ijms24065828.

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Amyotrophic lateral sclerosis (ALS) is regarded as a fatal neurodegenerative disease that is featured by progressive damage of the upper and lower motor neurons. To date, over 45 genes have been found to be connected with ALS pathology. The aim of this work was to computationally identify unique sets of protein hydrolysate peptides that could serve as therapeutic agents against ALS. Computational methods which include target prediction, protein-protein interaction, and peptide-protein molecular docking were used. The results showed that the network of critical ALS-associated genes consists of

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Du, Jian, Cheng-Fei Song, Shu Wang, Yu-Cheng Tan, and Jiang Wang. "Establishment and validation of a novel risk model based on CD8T cell marker genes to predict prognosis in thyroid cancer by integrated analysis of single-cell and bulk RNA-sequencing." Medicine 102, no. 42 (2023): e35192. http://dx.doi.org/10.1097/md.0000000000035192.

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Papillary thyroid cancer (PTC) is a histological type of thyroid cancer, and CD8T is important for the immune response. The single-cell RNA data were acquired from Gene Expression Omnibus. SingleR package was used for cluster identification, and CellChat was exploited to evaluate the interaction among several cell types. Bulk RNA data obtained from the cancer genome atlas were used for determination of prognosis using Kaplan–Meier and Receiver Operating Characteristic curve. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis were applied for assessment of function enrichmen

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Pan, Deng, Jiaxi Chen, Chunchao Feng, et al. "Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells." International Journal of Molecular Sciences 20, no. 2 (2019): 323. http://dx.doi.org/10.3390/ijms20020323.

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Lung cancer remains to be the leading cause of cancer-related mortality worldwide. Finding new noninvasive biomarkers for lung cancer is still a significant clinical challenge. Exosomes are membrane-bound, nano-sized vesicles that are released by various living cells. Studies on exosomal proteomics may provide clues for developing clinical assays. In this study, we performed semi-quantitative proteomic analysis of proteins that were purified from exosomes of NCI-H838 non-small cell lung cancer cell line, with total cellular membrane proteins as control. In the exosomes, LC-MS/MS by data-indepe

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Ye, Chenbo. "Exploring the role of aggrephagy-related signatures in immune microenvironment, prognosis, and therapeutic strategies of breast cancer." Medicine 103, no. 42 (2024): e39999. http://dx.doi.org/10.1097/md.0000000000039999.

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Breast cancer (BC) is 1 of the most common malignant tumors among women globally. This study aimed to develop a prognostic signature based on aggrephagy-related genes (ARGs). Transcriptomic and clinical data for BC patients were downloaded from the cancer genome atlas and GEO databases. Differential expression analysis, univariate Cox proportional hazards regression and least absolute shrinkage and selection operator Cox regression were employed to construct a prognostic signature. Consensus clustering, evaluation of immune infiltration and drug sensitivity, and gene set enrichment analysis, a

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Xu, Muge, and Jiening Gong. "Prognostic Signature, Immune Features, and Therapeutic Responses of a Novel Ubiquitination-Related Gene Signature in Lung Adenocarcinoma." Journal of Oncology 2022 (August 16, 2022): 1–13. http://dx.doi.org/10.1155/2022/2524649.

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Growing studies have implicated the association of ubiquitination-related genes (UbRGs) with the cancer progression and the long-term survival of patients. However, the prognostic values of UbRGs in lung adenocarcinoma (LUAD) have not been investigated. Our study aimed to establish a ubiquitination-related model for prognosis prediction and internal mechanism investigation. The transcriptome expression profiles and corresponding clinical information of LUAD were obtained from TCGA and GEO datasets. Differentially expressed genes (DEGs) were screened between LUAD specimens and nontumor specimen

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Luo, Wenhao, Zhe Cao, Jiangdong Qiu, Yueze Liu, Lianfang Zheng, and Taiping Zhang. "Novel Discoveries Targeting Pathogenic Gut Microbes and New Therapies in Pancreatic Cancer: Does Pathogenic E. coli Infection Cause Pancreatic Cancer Progression Modulated by TUBB/Rho/ROCK Signaling Pathway? A Bioinformatic Analysis." BioMed Research International 2020 (May 11, 2020): 1–12. http://dx.doi.org/10.1155/2020/2340124.

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Pancreatic cancer (PC) is a pernicious cancer of the digestive system which remains a high degree of malignancy. Increasing studies demonstrated that regulating the gut microbiome may become a brand new strategy to improve the therapeutic outcomes of PC. This study is aimed at obtaining the pathway in the microbial tumorigenesis of PC. Microarray datasets GSE27890, GSE46234, and GSE17610 were downloaded from the GEO (Gene Expression Omnibus) database. Differential analysis was performed for every single gene chip using the R software package (“Limma” package), and functional enrichment analyse

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Wang, Dazhi, Zheng Jiao, Yinghui Ji, and Shuyu Zhang. "Elevated TUBA1A Might Indicate the Clinical Outcomes of Patients with Gastric Cancer, Being Associated with the Infiltration of Macrophages in the Tumor Immune Microenvironment." Journal of Gastrointestinal and Liver Diseases 29, no. 4 (2020): 509–22. http://dx.doi.org/10.15403/jgld-2834.

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Background and Aims: TUBA1A belongs to the tubulin superfamily, and its role in gastric cancer (GC) remains unclear. This study assessed the expression and effect of TUBA1A in GC, as well as its association with survival and clinicopathological features. Gene set enrichment analysis (GSEA) results revealed that high TUBA1A expression was associated with multiple pathways, including those that contributed to the infiltration of macrophages in the tumor microenvironment. Since increased infiltration of macrophages can lead to oxaliplatin resistance, we analyzed the association between TUBA1A, th

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Strassel, Catherine, Agnes Hovasse, Sylvie Moog та ін. "Selected Expression and Functional Importance of α4a-Tubulin in Platelet Biogenesis". Blood 128, № 22 (2016): 1360. http://dx.doi.org/10.1182/blood.v128.22.1360.1360.

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Abstract Platelets are produced from mature megakaryocytes (MK) following a profound cellular reorganization. This includes the assembly of microtubules (MT) into a unique submenbranous coiled structure, the marginal band (MB). This process is thought to depend on a specific αβ-tubulin isotype repertoire. The MK-restricted-β1-tubulin, the predominant isoform of the MB, is already known to be important for platelet biogenesis but the implication of other isotypes is currently unknown. Our goal was to establish the αβ-tubulin repertoire in platelets and during megakaryopoiesis and to evaluate th

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I, Baba,, Waziri, I. A, Mukhtar, K. B та Abubakar, M. I. "Zuga Gishirin Waƙa: Nazarin Tubalan Zuga a Wasu Waƙoƙin Makaɗa Sa’idu Faru". Tasambo Journal of Language, Literature, and Culture 3, № 03 (2024): 109–16. http://dx.doi.org/10.36349/tjllc.2024.v03i03.015.

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Kusan an gina waƙoƙin baka a kan zuga da yabo da kambamawa da kirari da habaici da ba’a da sauran dangogin waɗannan zantuka na hikima. Akan zuga mutum ta hanyar abin da ya sani ko yake da shi, ko kuma akasin haka, sannan akan yi zuga domin munana wa wani ko ɓata masa, musamman ta hanyar ambatar abin da wani kininsa yake da shi, ko ya shahara da shi.. Wannan bincike, ya yi ƙoƙarin fito da tubalan zuga a wasu waƙoƙin Makaɗa Sa’idu Faru, inda binciken ya keɓanci waƙoƙi guda bakwai kacal, wanda a cikinsu ne aka ciro waɗannan tubalai na zuga. A binciken, an gano yadda Makaɗin ke ƙulla tubalan zuga

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Belvindrah, Richard, Kathiresan Natarajan, Preety Shabajee та ін. "Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration". Journal of Cell Biology 216, № 8 (2017): 2443–61. http://dx.doi.org/10.1083/jcb.201607074.

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Brain development involves extensive migration of neurons. Microtubules (MTs) are key cellular effectors of neuronal displacement that are assembled from α/β-tubulin heterodimers. Mutation of the α-tubulin isotype TUBA1A is associated with cortical malformations in humans. In this study, we provide detailed in vivo and in vitro analyses of Tuba1a mutants. In mice carrying a Tuba1a missense mutation (S140G), neurons accumulate, and glial cells are dispersed along the rostral migratory stream in postnatal and adult brains. Live imaging of Tuba1a-mutant neurons revealed slowed migration and incre

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Zhang, Ting, Dong-ming Wu, Shi-hua Deng, et al. "Integrated Analysis Reveals That Long Non-Coding RNA TUBA4B Can Be Used as a Prognostic Biomarker in Various Cancers." Cellular Physiology and Biochemistry 49, no. 2 (2018): 530–44. http://dx.doi.org/10.1159/000492991.

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Background/Aims: Recent studies have reported the importance of tubulin alpha 4b (TUBA4B), a long non-coding RNA, in the development of several cancers; however, studies on its clinical significance are rare. In the present meta-analysis, we investigated whether TUBA4B can be used as a prognostic biomarker in human cancers. Methods: A comprehensive search was performed in PubMed, Embase, Web of Science, and the Gene Expression Omnibus databases. Hazard ratios from individual studies were calculated and pooled using a random-effects or fix-effects model. The pooled hazard ratio (HR) with 95% co

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Kawauchi, Takeshi. "Tubulin isotype specificity in neuronal migration: Tuba8 can’t fill in for Tuba1a." Journal of Cell Biology 216, no. 8 (2017): 2247–49. http://dx.doi.org/10.1083/jcb.201705172.

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Several tubulin isotypes, including Tuba1a, are associated with brain malformations. In this issue, Belvindrah et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607074) show that Tuba1a and Tuba8 differentially regulate microtubule organization in neurons, and they provide insights into the mechanisms by which Tuba1a mutations disrupt adult mouse brain morphology.

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Yamane, Tsutomu, Takahiro Nakayama, Toru Ekimoto, et al. "Comparison of the Molecular Motility of Tubulin Dimeric Isoforms: Molecular Dynamics Simulations and Diffracted X-ray Tracking Study." International Journal of Molecular Sciences 24, no. 20 (2023): 15423. http://dx.doi.org/10.3390/ijms242015423.

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Tubulin has been recently reported to form a large family consisting of various gene isoforms; however, the differences in the molecular features of tubulin dimers composed of a combination of these isoforms remain unknown. Therefore, we attempted to elucidate the physical differences in the molecular motility of these tubulin dimers using the method of measurable pico-meter-scale molecular motility, diffracted X-ray tracking (DXT) analysis, regarding characteristic tubulin dimers, including neuronal TUBB3 and ubiquitous TUBB5. We first conducted a DXT analysis of neuronal (TUBB3-TUBA1A) and u

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Zefanya, Arsya Putri, and Isa Ansari Isa Ansari. "INTERPRETASI SIMBOLIK APAY SEBAGAI PROSES INISIASI MASYARAKAT TUBABA MELALUI PERTUNJUKAN TIKEW: CIRCLE OF LIFE." GETER : Jurnal Seni Drama, Tari dan Musik 8, no. 1 (2025): 27–45. https://doi.org/10.26740/geter.v8n1.p27-45.

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Tikew menjadi salah satu tumbuhan yang hidup di wilayah berlahan rawa khususnya di Kabupaten Tulang Bawang Barat, Tiyuh Gedung Ratu. Salah satu produk yang dihasilkan adalah Apay yang menjadi bagian dari kearifan lokal masyarakat Tubaba dalam kegunaan pada kehidupan sehari-hari. Pengimplementasian Apay sebagai penanda inisiasi bagi setiap proses hidup masyarakat Tubaba berkaitan langsung dengan falsafah yang mereka sebut ‘Hidup Tikew Mati Tikew’. Penelitian ini bertujuan untuk menjelaskan interpretasi simbolik Apay sebagai proses inisiasi hidup masyarakat Tubaba melalui pertunjukan karya Tikew

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Andrew, Bernard, Victor Daniel Simanjuntak, Sultan Rasyad Henkhazara, and Dewi Fadilasari. "EKSPLORASI GAYA ARSITEKTUR MODERN: Studi Kasus Masjid Islamic Center Tulang Bawang Barat." Jurnal Arsitektur ARCADE 7, no. 3 (2023): 368–71. http://dx.doi.org/10.31848/arcade.v7i3.1320.

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Abstract: Abstract: Architecture as a marker of civilization brings its characteristics in each era. The West Tulang Bawang (Tubaba) Islamic Center Mosque is a mosque with a center for Islamic activities in it. Designed with unique architecture and is different from other general mosque. In the application of architecture, the Tubaba Islamic Center Mosque has a theoretical value in terms of function, form, and meaning that cannot be separated from the Islamic religious elements in it. The function is applied as a center for Islamic activities, a different form from mosques in general but with

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Ujcikova, Hana, Adam Eckhardt, Lucie Hejnova, Jiri Novotny, and Petr Svoboda. "Alterations in the Proteome and Phosphoproteome Profiles of Rat Hippocampus after Six Months of Morphine Withdrawal: Comparison with the Forebrain Cortex." Biomedicines 10, no. 1 (2021): 80. http://dx.doi.org/10.3390/biomedicines10010080.

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The knowledge about proteome changes proceeding during protracted opioid withdrawal is lacking. Therefore, the aim of this work was to analyze the spectrum of altered proteins in the rat hippocampus in comparison with the forebrain cortex after 6-month morphine withdrawal. We utilized 2D electrophoretic workflow (Pro-Q® Diamond staining and Colloidal Coomassie Blue staining) which was preceded by label-free quantification (MaxLFQ). The phosphoproteomic analysis revealed six significantly altered hippocampal (Calm1, Ywhaz, Tuba1b, Stip1, Pgk1, and Aldoa) and three cortical proteins (Tubb2a, Tub

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Serna-García, Marta, Larissa Fernanda Simielli Fonseca, Joaquin Javier Panadero Panadero Romero, et al. "Transcriptome Profiling of the Liver in Nellore Cattle Phenotypically Divergent for RFI in Two Genetic Groups." Animals 13, no. 3 (2023): 359. http://dx.doi.org/10.3390/ani13030359.

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The identification and selection of genetically superior animals for residual feed intake (RFI) could enhance productivity and minimize environmental impacts. The aim of this study was to use RNA-seq data to identify the differentially expressed genes (DEGs), known non-coding RNAs (ncRNAs), specific biomarkers and enriched biological processes associated with RFI of the liver in Nellore cattle in two genetic groups. In genetic group 1 (G1), 24 extreme RFI animals (12 low RFI (LRFI) versus 12 high RFI (HRFI)) were selected from a population of 60 Nellore bulls. The RNA-seq of the samples from t

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Święch, Jan. "ROMAN TUBAJA (1944–2021)." Muzealnictwo 63 (April 7, 2022): 5–8. http://dx.doi.org/10.5604/01.3001.0015.8229.

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On 17 April 2021, Roman Tubaja, an ethnographer, museum curator, and a long-standing director of the Ethnographic Museum in Toruń named after Maria Znamierowska-Prüffer, passed away. Born on 16 February 1944 in Warlubie, Kociewie, he graduated in ethnography from the Jagiellonian University in 1966. As of 1967, he worked at the Ethnographic Museum in Toruń continuing there throughout all his career, and moving up the entire promotion ladder. Having been appointed Head of the Folk Architecture Department in 1970, in 1978, he was promoted to become Deputy Director for Research, while on 1 April

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Aiken, Jayne, Jeffrey K. Moore, and Emily A. Bates. "TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity." Human Molecular Genetics 28, no. 8 (2018): 1227–43. http://dx.doi.org/10.1093/hmg/ddy416.

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Abstract The microtubule cytoskeleton supports diverse cellular morphogenesis and migration processes during brain development. Mutations in tubulin genes are associated with severe human brain malformations known as ‘tubulinopathies’; however, it is not understood how molecular-level changes in microtubule subunits lead to brain malformations. In this study, we demonstrate that missense mutations affecting arginine at position 402 (R402) of TUBA1A α-tubulin selectively impair dynein motor activity and severely and dominantly disrupt cortical neuronal migration. TUBA1A is the most commonly aff

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Atılmış, Ümit Ünüvar, Bülent Şam, Elif Ülker Akyıldız, Osman Öztürk, and Oğuzhan Ekizoğlu. "Tubal Gebelik Rüptürü Nedenli Ani Ölüm Olgusu." Bulletin of Legal Medicine 12, no. 2 (2007): 78–81. http://dx.doi.org/10.17986/blm.2007122641.

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Ektopik gebelik, gebeliğin ilk trimesterinde görülen gebelikle ilişkili ölüm nedenlerinden biridir. Fertilize ovum implantas-yonun uterus dışında ve genellikle de tubada olması nedeniyle tubal gebelik olarak da adlandırılır. Tubal gebelik, tubal rüptür ve batın içi kanamaya neden olarak ani ölüme yol açabilmektedir. Ektopik gebelik rüptürü nedenli ani ölümler, sık rastlanılmayan ani ölüm nedenlerindendir. Sıklıkla tam güçlükleri yaşanmaktadır. Özellikle genç erişkin kadında ani ölüm nedenleri arasında ayırıcı tanıya alınmalıdır. Ölümden 3-4 hafta önce küretaj öyküsü olan 22 yaşındaki olgu, kar

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Curiel, Julian, Guillermo Rodríguez Bey, Asako Takanohashi, et al. "TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes." Human Molecular Genetics 26, no. 22 (2017): 4506–18. http://dx.doi.org/10.1093/hmg/ddx338.

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Abstract Hypomyelinating leukodystrophies are heritable disorders defined by lack of development of brain myelin, but the cellular mechanisms of hypomyelination are often poorly understood. Mutations in TUBB4A, encoding the tubulin isoform tubulin beta class IVA (Tubb4a), result in the symptom complex of hypomyelination with atrophy of basal ganglia and cerebellum (H-ABC). Additionally, TUBB4A mutations are known to result in a broad phenotypic spectrum, ranging from primary dystonia (DYT4), isolated hypomyelination with spastic quadriplegia, and an infantile onset encephalopathy, suggesting m

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Shuni, Mustapha Ahmad, and Jamilu Ibrahim Mukoshy. "Matakan Ginin Karin Maganganu Na Mutane Masu Buƙata Ta Musamman." Scholars International Journal of Linguistics and Literature 6, no. 09 (2023): 393–98. http://dx.doi.org/10.36348/sijll.2023.v06i09.004.

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Wannan maƙalar ta yi nazarin karin maganganu na mutane masu buƙata ta musamman domin gano falsafar Bahaushe a kan wannan rukunin mutane da kuma tubalan da ake amfani da su wajen ginin karin maganganu masu alaƙa da su. Binciken ya yi amfani da manya da ƙananan hanyoyin tattara bayanai waɗanda suka haɗa da: Tattaunawa da lura ta kai-tsaye, da sauraren kafafen yaɗa labarai da ziyartar ɗakunan karatu na manyan makarantu don samun bayanai da karin maganganu masu alaƙa da mutane masu buƙata ta musamman. Sakamakon binciken ya yi nasarar fito da falsafar Bahaushe kan mutane masu buƙata ta musamman da

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Koning, Tania, and Gloria M. Calaf. "Genes Related to Motility in an Ionizing Radiation and Estrogen Breast Cancer Model." Biology 13, no. 11 (2024): 849. http://dx.doi.org/10.3390/biology13110849.

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Breast cancer is a major global health concern as it is the primary cause of cancer death for women. Environmental radiation exposure and endogenous factors such as hormones increase breast cancer risk, and its development and spread depend on cell motility and migration. The expression of genes associated with cell motility, such as ADAM12, CYR61, FLRT2, SLIT2, VNN1, MYLK, MAP1B, and TUBA1A, was analyzed in an experimental breast cancer model induced by radiation and estrogen. The results showed that TUBA1A, SLIT2, MAP1B, MYLK, and ADAM12 gene expression increased in the irradiated Alpha3 cel

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Lohmann, Katja, and Christine Klein. "The many faces of TUBB4A mutations." neurogenetics 15, no. 2 (2014): 81–82. http://dx.doi.org/10.1007/s10048-014-0399-8.

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Hu, Xinyao, Hua Zhu, Biao Chen, et al. "Tubulin Alpha 1b Is Associated with the Immune Cell Infiltration and the Response of HCC Patients to Immunotherapy." Diagnostics 12, no. 4 (2022): 858. http://dx.doi.org/10.3390/diagnostics12040858.

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Tubulin alpha 1b (TUBA1B) is an important microtubule isoform that is involved in the formation of the cytoskeleton. The objective of our study was to explore the potential of TUBA1B in predicting the prognosis of HCC and patients’ response to immunotherapy. Raw data was extracted from TCGA and GEO databases, and then HCCDB, TIMER, HPA, and GEPIA websites, as well as R software, were used to perform bioinformatics analysis to investigate the potential of TUBA1B as a prognostic and immunotherapeutic marker for hepatocellular carcinoma (HCC). We found that both TUBA1B mRNA and protein were highl

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Muntaqo, Firman, Mashudi Mashudi, Murzal Zaidan, and Fahmi Yoesmar Ar-Rasyidi. "The Synchronization Process of Legal System in Tunggu Tubang Land Certification." Jurnal Akta 9, no. 1 (2022): 79. http://dx.doi.org/10.30659/akta.v9i1.21090.

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The study on the Tunggu Tubang Land Certification in the Semende area aims to examine 3 (three) problems, they are aspects of historical and sociological rechts supporting and inhibiting; synchronization of the legal system, as well as; alternative arrangements for facilitation of Tunggu Tubang land certification. The research used a normative juridical approach. The results of the study state that the study of synchronization of the legal system, there are no obstacles to the certification of Tunggu Tubang land, with the argument that the Tunggu Tubang land comes from private land (land of cu

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Gardner, Jennifer, Thomas Cushion, Georgios Niotakis, et al. "Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation." Brain Sciences 8, no. 8 (2018): 145. http://dx.doi.org/10.3390/brainsci8080145.

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The TUBA1A gene encodes tubulin alpha-1A, a protein that is highly expressed in the fetal brain. Alpha- and beta-tubulin subunits form dimers, which then co-assemble into microtubule polymers: dynamic, scaffold-like structures that perform key functions during neurogenesis, neuronal migration, and cortical organisation. Mutations in TUBA1A have been reported to cause a range of brain malformations. We describe four unrelated patients with the same de novo missense mutation in TUBA1A, c.5G>A, p.(Arg2His), as found by next generation sequencing. Detailed comparison revealed similar brain phen

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