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1

Akhtar, Komal, Ishtiaq Ahmed, Muhammad Yasin Tipu, et al. "Molecular identification and infection pathology of Mycobacterium spp. in captive wild animals in Pakistan." Journal of Infection in Developing Countries 17, no. 08 (2023): 1107–13. http://dx.doi.org/10.3855/jidc.17287.

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Introduction: Animal tuberculosis is an infectious, chronic, granulomatous, and debilitating disease affecting animals as well as humans. However, in recent decades, there have been many endemic geographic localities where animal tuberculosis has been identified in wildlife reservoirs, limiting the eradication program in cattle. This study aimed to identify animal tuberculosis in captive zoo animals in Pakistan. Methodology: In total, 185 morbid zoo animals were brought for postmortem examination at a veterinary postmortem facility. During the macroscopic examination, these animals were thorou
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2

Collins, J. D. "Tuberculosis in animals." Irish Journal of Medical Science 154, S1 (1985): 15–23. http://dx.doi.org/10.1007/bf02938287.

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3

Getahun, Temesgen K., Fekadu Gutema, and Fikadu Wodajo. "Status and Public Health Significance of Mycobacterium bovis in Ethiopia." Veterinary Medicine – Open Journal 8, no. 1 (2023): 18–28. http://dx.doi.org/10.17140/vmoj-8-173.

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Infectious diseases, accounting for 30-50% of the total annual losses, remain a major impediment to Ethiopia’s livestock economy. Cattle, other domesticated animals, and some free-range or captive wildlife species are all susceptible to the infectious disease known as bovine tuberculosis, which is caused by the Mycobacterium bovis (M. bovis). It is typically distinguished by the development of tubercle-like nodular granulomas. The bovine tuberculosis-diseased animal loses 10-25% of their productive efficiency; direct losses due to the infection become evident by a decrease in 10-18% milk and a
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Kashino, Suely S., Pamela Ovendale, Angelo Izzo, and Antonio Campos-Neto. "Unique Model of Dormant Infection for Tuberculosis Vaccine Development." Clinical and Vaccine Immunology 13, no. 9 (2006): 1014–21. http://dx.doi.org/10.1128/cvi.00120-06.

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ABSTRACT Most individuals exposed to Mycobacterium tuberculosis become infected but hinder the infectious process in dormant foci, known as latent tuberculosis. This limited infection usually stimulates strong T-cell responses, which provide lifelong resistance to tuberculosis. However, latent tuberculosis is still poorly understood, particularly because of the lack of a reliable animal model of dormant infection. Here we show that inoculation of mice with a unique streptomycin-auxotrophic mutant of Mycobacterium tuberculosis recapitulates dormant infection. The mutant grows unimpaired in the
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Pandey, G., S. Dhakal, A. Sadaula, et al. "Status of tuberculosis in bovine animals raised by tuberculosis infected patients in Western Chitwan, Nepal." International Journal of Infection and Microbiology 1, no. 2 (2013): 49–53. http://dx.doi.org/10.3126/ijim.v1i2.7407.

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INTRODUCTION: Bovine tuberculosis (bTB) is an important public health concern worldwide. This study was conducted to determine the status of bTB in animals raised by tuberculosis patients in Western Chitwan, Nepal. MATERIALS AND METHODS: This cross-sectional study was conducted from August, 2011 to January, 2012. A total of 100 bovines (cattle and buffalo) raised in 60 farms of tuberculosis patients were tested with single intradermal tuberculin test considering various animal factors. Well designed questionnaire survey was taken with 70 tuberculosis patients of same 60 families focusing knowl
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Diallo, Boubacar, Jeconia Abonyo Okelo, Shaibu Osman, Simon Karanja, and Nnaemeka Stanley Aguegboh. "Fractional-Order Model for Evolution of Bovine Tuberculosis with Vaccination and Contaminated Environment." Journal of Applied Mathematics 2024 (January 24, 2024): 1–15. http://dx.doi.org/10.1155/2024/6934895.

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Bovine tuberculosis (bTB) is a zoonotic disease that is commonly transmitted via inhaling aerosols, drinking unpasteurized milk, and eating raw meat. We use a fractional-order model with the Caputo sense to examine the evolution of bovine tuberculosis transmission in human and animal populations, including a vaccine compartment for humans. We derived and obtained the threshold quantity R0 to ascertain the illness state. We established conditions guaranteeing the asymptotic stability of the equilibria (locally and globally). Sensitivity analysis was conducted to identify the factors that govern
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7

Cracknell, Jonathan. "Tuberculosis in animals and humans." Veterinary Record 174, no. 25 (2014): 637.1–637. http://dx.doi.org/10.1136/vr.g4082.

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8

Donchenko, A. S., N. A. Donchenko, A. S. Zhumash, A. K. Shaymbetova, A. В. Turgumbekov, and A. К. Ilimbayeva. "Prevention of tuberculosis of cattle imported from abroad." Siberian Herald of Agricultural Science 49, no. 6 (2020): 53–61. http://dx.doi.org/10.26898/0370-8799-2019-6-6.

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When importing cattle from Hungary, Germany, Holland and Australia, many violations of veterinary rules for cattle management for the purpose of its reproduction, rearing and sale were noted. Pathogens of a number of infectious diseases penetrate livestock farms with the cattle purchased. Cases of infection of imported pedigree cattle with tuberculosis were noted. Scientists, together with practical experts of the Republic of Kazakhstan and the Russian Federation, conducted a series of surveys of livestock farms, where pedigree cattle was imported from abroad. The imortance of the veterinary-s
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9

Ncube, Pamela, Bahareh Bagheri, Wynand Johan Goosen, Michele Ann Miller, and Samantha Leigh Sampson. "Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals." Microorganisms 10, no. 9 (2022): 1845. http://dx.doi.org/10.3390/microorganisms10091845.

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Mycobacterium bovis and other Mycobacterium tuberculosis complex (MTBC) pathogens that cause domestic animal and wildlife tuberculosis have received considerably less attention than M. tuberculosis, the primary cause of human tuberculosis (TB). Human TB studies have shown that different stages of infection can exist, driven by host–pathogen interactions. This results in the emergence of heterogeneous subpopulations of mycobacteria in different phenotypic states, which range from actively replicating (AR) cells to viable but slowly or non-replicating (VBNR), viable but non-culturable (VBNC), an
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10

STEPHENS, N., L. VOGELNEST, C. LOWBRIDGE, et al. "Transmission ofMycobacterium tuberculosisfrom an Asian elephant (Elephas maximus) to a chimpanzee (Pan troglodytes) and humans in an Australian zoo." Epidemiology and Infection 141, no. 7 (2013): 1488–97. http://dx.doi.org/10.1017/s095026881300068x.

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SUMMARYMycobacterium tuberculosisis primarily a pathogen of humans. Infections have been reported in animal species and it is emerging as a significant disease of elephants in the care of humans. With the close association between humans and animals, transmission can occur. In November 2010, a clinically healthy Asian elephant in an Australian zoo was found to be sheddingM. tuberculosis; in September 2011, a sick chimpanzee at the same zoo was diagnosed with tuberculosis caused by an indistinguishable strain ofM. tuberculosis.Investigations included staff and animal screening. Four staff had t
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11

Chugh, IB, and GK Khuller. "Immunoprotective behaviour of liposome entrapped cell wall subunit of Mycobacterium tuberculosis against experimental tuberculous infection in mice." European Respiratory Journal 6, no. 6 (1993): 811–15. http://dx.doi.org/10.1183/09031936.93.06060811.

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We wanted to determine the immunoprotective behaviour of cell wall protein peptidoglycan complex (CW-PPC) of Mycobacterium tuberculosis H37Ra, using liposomes as adjuvant, in an experimental animal model. Immunization of mice with CW-PPC entrapped in liposomes induced both humoral response, as measured by enzyme-linked immunosorbent assay (ELISA), and cell-mediated immune responses, as seen by delayed type hypersensitivity (DTH) and leucocyte migration inhibition (LMI) techniques. Ten days after complete immunization, the animals were challenged with median lethal dose (LD50) of M. tuberculosi
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Khairullah, Aswin, Ikechukwu Moses, Muhammad Kusala, et al. "Unveiling insights into bovine tuberculosis: A comprehensive review." Open Veterinary Journal 14, no. 6 (2024): 1330. http://dx.doi.org/10.5455/ovj.2024.v14.i6.2.

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The frequent zoonotic disease known as "bovine tuberculosis" is brought on by the Mycobacterium bovis bacteria, which can infect both people and animals. The aim of this review article is to provide an explanation of the etiology, history, epidemiology, pathogenesis, clinical symptoms, diagnosis, transmission, risk factors, public health importance, economic impact, treatment, and control of bovine tuberculosis. Primarily, bovine tuberculosis affects cattle, but other animals may also be affected. Bovine tuberculosis is present throughout the world, with the exception of Antarctica. Cattle tha
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13

Afanaseva, Faina M., Dariko A. Niauri, Tatiana I. Vinogradova, et al. "Mesenchymal stromal cells application for experimental genital tuberculosis combination therapy." Journal of obstetrics and women's diseases 71, no. 2 (2022): 29–38. http://dx.doi.org/10.17816/jowd84506.

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BACKGROUND: Cell therapy is a promising trend in treating characterized by inflammation and sclerosis diseases such as genital tuberculosis, marked by pelvic inflammatory disease and uterine tube occlusion.
 AIM: Efficacy evaluation of combined mesenchymal stem cells and specific polychemotherapy treatment of the experimental genital tuberculosis.
 MATERIALS AND METHODS: Chinchilla rabbits (n = 27) were divided on 4 groups. Group 1 (n = 6) comprised control group, healthy animals. Group 2 (n = 7) infected with genital tuberculosis, without treatment. Group 3 (n = 7) infected with gen
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14

Shirima Sabini, Theresia, Jacob Ismail Irunde, and Dmitry Kuznetsov. "Modeling the Transmission Dynamics of Bovine Tuberculosis." International Journal of Mathematics and Mathematical Sciences 2020 (March 30, 2020): 1–14. http://dx.doi.org/10.1155/2020/7424075.

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Bovine tuberculosis (bTB) is a bacterial and zoonotic disease which is transmitted through consumption of unpasteurized milk and uncooked meat and inhalation of aerosols. In this paper, a deterministic mathematical model is formulated to study the transmission dynamics of bTB in humans and animals. The basic reproduction number R0 is computed to determine the behavior of the disease. Stability analysis shows that there is a possibility for disease-free equilibrium and endemic equilibrium to coexist when R0 = 1. To determine parameters which drive the dynamics of bTB, we performed sensitivity a
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15

Cadmus, S., V. Oluwatoyin Akinseye, and D. van Soolingen. "Mycobacterium bovis in humans and M. tuberculosis in animals in Nigeria: an overview from 1975–2014." International Journal of Tuberculosis and Lung Disease 23, no. 11 (2019): 1162–70. http://dx.doi.org/10.5588/ijtld.18.0641.

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Zoonotic transmission of mycobacteria between humans and other animal species is an important aspect of the epidemiology of tuberculosis (TB) in regions of the world where the burden of the disease in humans and other animals is high. This is particularly important in areas in which sociocultural factors increase the possibility for interspecies transmission of different mycobacteria. Carrying out a review of the published literature involving laboratory-confirmed TB cases (by culture) and/or biochemical and molecular identification, we described the presence of Mycobacterium bovis and M. tube
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16

Dahiru, M. H., S. N. A. Saidu, L. B. Tekdek, et al. "Knowledge, attitude and practices of small ruminant butchers on tuberculosis in selected areas of Katsina State, Nigeria." Sokoto Journal of Veterinary Sciences 21, no. 1 (2023): 21–31. http://dx.doi.org/10.4314/sokjvs.v21i1.3.

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A questionnaire survey was conducted on the knowledge, attitude and practices of butchers on tuberculosis in small ruminants in selected areas of Katsina State, Nigeria. All respondents had some level of formal education. Animals slaughtered included cattle (18.0%), sheep (34.0%), goats (53.0%) and camels (4.0%). Animals were slaughtered in the countryside (23.0%), within the village (24.0%) and in community areas (57.0%). The butchers knew small ruminants could acquire tuberculosis and that tuberculosis could infect humans along with its signs and modes of transmission in animals and humans.
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17

Kukuh Judy Handojo, Rosida,. "POTENSI EKSTRAK KENCUR (Kaemferia galanga L.) SEBAGAI IMUNOMODULATOR PADA TIKUS MODEL YANG TERINFEKSI Mycobacterium tuberculosis." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 3, no. 1 (2021): 8–13. http://dx.doi.org/10.53864/jifakfar.v3i1.37.

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Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis can infect anyone in the patient's environment. Someone with good body immunity conditions will avoid tuberculosis. Increased immunity for tuberculosis sufferers is very important. The active substances contained in plants such as flavonoids and essential oils are important components in supporting the body's immunity. One plant that contains flavonoids and essential oils is kencur (Kaemferia galanga L.). This study aims to prove the potential of kencur extract as an immunomodulator in model rat infected w
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18

Tazerart, Fatah, Jamal Saad, Naima Sahraoui, Djamel Yala, Abdellatif Niar, and Michel Drancourt. "Whole Genome Sequence Analysis of Mycobacterium bovis Cattle Isolates, Algeria." Pathogens 10, no. 7 (2021): 802. http://dx.doi.org/10.3390/pathogens10070802.

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Mycobacterium bovis (M. bovis), a Mycobacterium tuberculosis complex species responsible for tuberculosis in cattle and zoonotic tuberculosis in humans, is present in Algeria. In Algeria however, the M. bovis population structure is unknown, limiting understanding of the sources and transmission of bovine tuberculosis. In this study, we identified the whole genome sequence (WGS) of 13 M. bovis strains isolated from animals exhibiting lesions compatible with tuberculosis, which were slaughtered and inspected in five slaughterhouses in Algeria. We found that six isolates were grouped together wi
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19

I B Cadmus, S., N. N Atsanda, S. O Oni, and E. E U Akang. "Bovine tuberculosis in one cattle herd in Ibadan in Nigeria." Veterinární Medicína 49, No. 11 (2012): 406–12. http://dx.doi.org/10.17221/5730-vetmed.

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Bovine tuberculosis was investigated in one private herd with 171 cattle after five cases were suspected to be tuberculous following post mortem examination. Using the intradermal comparative cervical tuberculin test 18 (10.5%) animals (ages from 2 to 12 years) were positive: 11 animals of N’dama breed and seven animals of White Fulani (i.e. Bunaji) breed; 17 female and one male animal. In all 11 randomly selected positive reactors, a spectrum of tuberculous lesions affecting the lungs, spleen, heart, liver, and the lymph nodes were observed. All the smear samples obtained w
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20

Pušić, Ivan, Dušan Lalošević, Dejan Bugarski, et al. "EPIZOOTIOLOGICAL CHARACTERISTICS OF BOVINE TUBERCULOSIS IN SOUTH BAČKA REGION." Archives of Veterinary Medicine 2, no. 1 (2009): 55–63. http://dx.doi.org/10.46784/e-avm.v2i1.212.

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Bovine tuberculosis caused by Mycobacterium bovis is a chronicle, infective disease associated with formation of specific inflammatory granulomas. Infection usually remains subclinical for a long period, but even when the clinical are present, they are not pathognomic. Bovine tuberculosis can spread to humans through inhalation of infectious droplets and by ingestion of raw milk, and on the rare occasion through consumption of meat products. Since the disease remains a great economic concern for cattle production operations and due to its zoonotic nature, most of the countries initiated a prog
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Ferreira Neto, José Soares, Regina Gonçalves Barbosa, Fernando Ferreira, et al. "Epidemiological situation of bovine tuberculosis in the state of Tocantins, Brazil." Semina: Ciências Agrárias 42, no. 3Supl1 (2021): 1673–84. http://dx.doi.org/10.5433/1679-0359.2021v42n3supl1p1673.

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The epidemiological situation of bovine tuberculosis was studied from October 2014 to August 2015 in the state of Tocantins, a traditional beef exporter. The state was divided into five regions and the farms were randomly selected in each region. A predetermined number of animals was randomly selected and diagnosed using the Comparative Cervical Tuberculin Test. A total of 11,926 animals from 757 farms were tested. Animals with inconclusive test results were retested with the same diagnostic procedure at least 60 days later. The prevalence of infected herds in the state was 0.16% [0.02-1.15] a
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Jovanovic, Milijan, and Milijana Knezevic. "Para tuberculosis (Johnes disease): Basic characteristics and current situation locally." Veterinarski glasnik 59, no. 5-6 (2005): 507–19. http://dx.doi.org/10.2298/vetgl0506507j.

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Para tuberculosis or Johne's Disease, is a disease of the digestive tract of animals caused by Mycobacterium avium subspecies Para tuberculosis (M. a. Para tuberculosis). Para tuberculosis has been registered in many countries and it today presents one of the most widely-spread bacterial diseases in ruminants that causes severe economic damages. In our country, Para tuberculosis has not been studied extensively. The disease was registered for the first time in Serbia in 1995 in an isolated herd of sheep of the II-de-France breed, and serologically positive cattle were determined in 2001. Infec
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Korniienko, L. Y., A. V. Pyskun, V. V. Ukhovskyi, et al. "Retrospective analysis of the control and prevention of tuberculosis among cattle in Ukraine in the period 1994–2020." Regulatory Mechanisms in Biosystems 12, no. 2 (2021): 301–6. http://dx.doi.org/10.15421/022140.

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Bovine tuberculosis (bTB) – is a chronic infectious disease, the causative agent of which affects many species of mammals. It is a zoonosis caused by various types of mycobacteria in the complex Mycobacterium tuberculosis family Mycobacteriaceae. The most important etiological agent of bTB in cattle is M. bovis, which has been isolated from tuberculosis infected cattle for centuries. Livestock and species of the Bovidae family are the most susceptible to this pathogen and are the main reservoir species for animals and humans. In Ukraine, the main methods of diagnosing tuberculosis in animal hu
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24

Gong, Wenping, Yan Liang, and Xueqiong Wu. "Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis." BioMed Research International 2020 (January 8, 2020): 1–21. http://dx.doi.org/10.1155/2020/4263079.

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Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is one of the top ten infectious diseases worldwide, and is the leading cause of morbidity from a single infectious agent. M. tuberculosis can cause infection in several species of animals in addition to humans as the natural hosts. Although animal models of TB disease cannot completely simulate the occurrence and development of human TB, they play an important role in studying the pathogenesis, immune responses, and pathological changes as well as for vaccine research. This review summarizes the commonly employed a
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Kumar, Rajnish, Parminder Jit Kaur, G. K. Khuller, and Indu Verma. "Immunogenicity Studies with Microbial Fractions of M. tuberculosis H37Rv Total Culture Filtrate." International Journal of Biology 8, no. 1 (2015): 48. http://dx.doi.org/10.5539/ijb.v8n1p48.

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<p class="1Body">Current study investigates the whole secretory proteome of <em>Mycobacterium tuberculosis</em> as culture filtrate fractions to identify immunoprotective protein antigens on the basis of protection studies in animal (mouse and guinea pig) models. Secretory culture filtrate proteins (CFPs) of <em>M. tuberculosis</em> H<sub>37</sub>Rv were fractionated into fifteen narrow molecular mass fractions in the order of increasing molecular size (F1-F15) by electroelution. Immunization studies revealed proteins in the molecular weight range of 2
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Anusz, Krzysztof, Blanka Orłowska, Monika Krajewska-Wędzina, et al. "Ante-mortem and post-mortem tuberculosis diagnostics in three European Bison from the enclosure in Bukowiec in the Bieszczady National Park in Poland." Medycyna Weterynaryjna 73, no. 10 (2017): 642–46. http://dx.doi.org/10.21521/mw.5786.

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The ante-mortem diagnostics of tuberculosis in wildlife constitutes a major problem due to the difficulties in collecting samples for examination. Therefore, tuberculosis in free-living animals is usually diagnosed post mortem. Ante-mortem examinations for bovine tuberculosis (BTB) were conducted in three European bison living in an acclimatisation enclosure in Bukowiec in the Bieszczady National Park in Poland. The reason for performing these examinations was the documented contact between the aforementioned animals and tuberculous European bison from a free-living herd present in the area. T
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Rodrigues, Rudielle A., Ingrid I. F. S. Meneses, Klaudia S. G. Jorge, et al. "False-negative reactions to the comparative intradermal tuberculin test for bovine tuberculosis." Pesquisa Veterinária Brasileira 37, no. 12 (2017): 1380–84. http://dx.doi.org/10.1590/s0100-736x2017001200004.

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ABSTRACT: According to the Brazilian National Program for the Control and Eradication of Animal Brucellosis and Tuberculosis (PNCEBT), the routine tests for the diagnosis of bovine tuberculosis in the country are the simple intradermal tuberculin test (SITT) of the Ministry of Agriculture, Livestock and Food Supply (MAPA), the caudal fold test and the comparative intradermal tuberculin test (CITT). The latter is also used as a confirmatory test. A group of 53 animals from three dairy herds in a focal area for bovine tuberculosis, that were submitted to depopulation in the state of Rio Grande d
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BAKER, M. G., L. D. LOPEZ, M. C. CANNON, G. W. DE LISLE, and D. M. COLLINS. "Continuing Mycobacterium bovis transmission from animals to humans in New Zealand." Epidemiology and Infection 134, no. 5 (2006): 1068–73. http://dx.doi.org/10.1017/s0950268806005930.

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New Zealand has a large reservoir of Mycobacterium bovis infection in wild and farmed animals. This study aimed to assess the extent of human infection with this organism and the potential contribution of these animal sources. Combined epidemiological and laboratory investigation of human tuberculosis cases over the period 1995–2002 showed that M. bovis accounted for 2·7% (54/1997) of laboratory-confirmed human tuberculosis cases, a rate of 0·2/100000 population. M. bovis isolates from humans (23) were typed using restriction endonuclease analysis (REA) and compared with isolates from wild and
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Harth, Günter, and Marcus A. Horwitz. "Inhibition of Mycobacterium tuberculosis Glutamine Synthetase as a Novel Antibiotic Strategy against Tuberculosis: Demonstration of Efficacy In Vivo." Infection and Immunity 71, no. 1 (2003): 456–64. http://dx.doi.org/10.1128/iai.71.1.456-464.2003.

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ABSTRACT Tuberculosis remains one of humankind's greatest killers, and new therapeutic strategies are needed to combat the causative agent, Mycobacterium tuberculosis, which is rapidly developing resistance to conventional antibiotics. Using the highly demanding guinea pig model of pulmonary tuberculosis, we have investigated the feasibility of inhibiting M. tuberculosis glutamine synthetase (GS), an enzyme that plays a key role in both nitrogen metabolism and cell wall biosynthesis, as a novel antibiotic strategy. In guinea pigs challenged by aerosol with the highly virulent Erdman strain of
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Barcelos, Flávio Gomes, Taís Ramalho dos Anjos, Leila Auxiliadora de Arruda Alencar, et al. "Risk factors associated with the presence of Mycobacterium bovis in macroscopic lesions suspected as being caused by bovine tuberculosis detected in slaughterhouses." Semina: Ciências Agrárias 43, no. 2 (2022): 713–26. http://dx.doi.org/10.5433/1679-0359.2022v43n2p713.

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Mycobacterium bovis is a bacterium belonging to the Mycobacterium tuberculosis complex that causes tuberculosis in cattle and in other domestic and wild animals, as well as in humans. Disease control measures are carried out by slaughtering animals tested positive in the intradermal tuberculinization test and sanitation of their original living spaces, in addition to epidemiological surveillance carried out through the sanitary inspection of bovine carcasses in slaughterhouses. In the latter, official inspection services collect samples from macroscopic lesions suspected of bovine tuberculosis
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Krajewska-Wędzina, Monika, Monika Kozińska, Blanka Orłowska, et al. "Molecular characterisation of Mycobacterium caprae strains isolated in Poland." Veterinary Record 182, no. 10 (2017): 292. http://dx.doi.org/10.1136/vr.104363.

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Bovine tuberculosis (bovine TB, bTB) is caused by bovine bacilli: Mycobacterium bovis and M caprae. The studies conducted in Poland, in the National Bovine Tuberculosis Reference Laboratory in the Department of Microbiology of the National Veterinary Research Institute in Pulawy, show that animal tuberculosis in Poland is also caused by M caprae. We here describe the identification and genotypic assessment of 52 isolates of M caprae obtained from Polish cattle and wild animals over the last five years. We show that strains isolated from bison have significant genotypic diversity and are distin
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WELZ, MIROSŁAW, PRZEMYSŁAW ŁOŚ, RENATA KONDRAT, BLANKA ORŁOWSKA, ANNA DIDKOWSKA, and KRZYSZTOF ANUSZ. "Combating tuberculosis in European bison in the Bieszczady Mountains - administrative aspect." Medycyna Weterynaryjna 79, no. 04 (2023): 6756–2023. http://dx.doi.org/10.21521/mw.6756.

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Tuberculosis in animals is an infectious and contagious disease, caused by acid-fast bacilli of the Mycobacterium tuberculosis complex. The disease has been confirmed in Poland in farm and wild animals. Among the latter the largest number of cases was diagnosed in free-ranging European bison in the Bieszczady Mountains. The disease has also been present there since 2013 in the wild boar population. From April 21, 2021, in accordance with EU Regulation 2016/429, tuberculosis in European bison is a disease that is subject to mandatory eradication in all EU Member States. In Poland and in most EU
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33

Nuratinov, R. A., N. Kh Mesrobyan, E. A. Verdieva, and A. A. Sultanov. "SOCIO-HYGIENIC IMPORTANCE OF TUBERCULOSIS OF ANIMALS." South of Russia: ecology, development, no. 4 (November 16, 2014): 129. http://dx.doi.org/10.18470/1992-1098-2012-4-129-133.

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34

Behr, Marcel A., and Stephen V. Gordon. "Why doesn’t Mycobacterium tuberculosis spread in animals?" Trends in Microbiology 23, no. 1 (2015): 1–2. http://dx.doi.org/10.1016/j.tim.2014.11.001.

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35

Pavlik, I., W. Yayo Ayele, I. Parmova, et al. "Mycobacterium tuberculosis in animal and human populations in six Central European countries during 1990–1999." Veterinární Medicína 48, No. 4 (2012): 83–89. http://dx.doi.org/10.17221/5754-vetmed.

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Results of Mycobacterium tuberculosis detection in animals from six Central European countries (Croatia, the Czech Republic, Hungary, Poland, Slovakia and Slovenia) spreading over 610 402 km<sup>2 </sup>with a population of 11.8 million heads of cattle were analysed. In the monitoring period, 1990 to 1999, M. tuberculosis from animals was isolated only in two countries (Poland and Slovak Republic) from 16 animals with tuberculous lesions. These comprise nine heads of cattle (Bos taurus), four domestic pigs (Sus scrofa f. domestica) and three wild
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36

Baratov, M. O. "Problems and prospects of bovine tuberculosis serological diagnosis." Veterinary Science Today 1, no. 1 (2021): 33–37. http://dx.doi.org/10.29326/2304-196x-2021-1-36-33-37.

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For the purposes of tuberculosis eradication on any tuberculosis-infected farm, it is necessary to identify tuberculin anergic animals, being a potential source of the infection. The purpose of this study was to analyze the role of complement fixing and haemagglutinating antibodies for the detection cattle infected with bovine tuberculosis (TB). 977 cattle of different sex and age groups on two tuberculosis-infected farms were tested thrice over time. After 35 days all tuberculin reactive cattle (132 animals; 13.5%) were subjected to complex testing using allergy and serology methods. After 40
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Pal, Mahendra, Dinaol Tolawak, and Urgessa Bikila. "Zoonotic Importance of Bovine Tuberculosis in Ethiopia: An Overview." Research in Veterinary Science and Medicine 2 (September 13, 2022): 7. http://dx.doi.org/10.25259/rvsm_6_2022.

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Bovine tuberculosis (BTB) is an important zoonotic disease that affects both domestic animals as well as humans in many countries of the world. The disease is caused by Mycobacterium bovis, which is responsible for 10–15% of human tuberculosis cases. BTB poses an occupational health hazard to the cattle owners, butchers, animal attendants, and veterinarians. The source of infection is exogenous and the respiratory tract is considered the chief portal of entry of the organism. The mode of spread of bacteria is aerogenous. BTB is endemic in Ethiopia, and it is mostly transmitted to people throug
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Waters, W. R., A. O. Whelan, K. P. Lyashchenko, et al. "Immune Responses in Cattle Inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii." Clinical and Vaccine Immunology 17, no. 2 (2009): 247–52. http://dx.doi.org/10.1128/cvi.00442-09.

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ABSTRACT Cattle were inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii to compare the antigen-specific immune responses to various patterns of mycobacterial disease. Disease expression ranged from colonization with associated pathology (M. bovis infection) and colonization without pathology (M. tuberculosis infection) to no colonization or pathology (M. kansasii infection). Delayed-type hypersensitivity and gamma interferon responses were elicited by each mycobacterial inoculation; however, the responses by the M. bovis- and M. tuberculosis-inoculated a
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Amanfu, William. "The situation of tuberculosis and tuberculosis control in animals of economic interest." Tuberculosis 86, no. 3-4 (2006): 330–35. http://dx.doi.org/10.1016/j.tube.2006.01.007.

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Yeremeev, V. V., G. S. Shepelkova, I. V. Dukhovlinov, and V. Ya Gergert. "PROTECTIVE EFFECT INDUCED BY THE NEW SUBUNIT TUBERCULOSIS VACCINE WHEN USED AS A BCG BOOST IS ASSOCIATED WITH INHIBITION OF MYCOBACTERIAL DISSEMINATION." Medical Immunology (Russia) 21, no. 3 (2019): 555–58. http://dx.doi.org/10.15789/1563-0625-2019-3-555-558.

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Since 1924, BCG vaccine is used to protect children from the most severe forms of tuberculosis. At the same time, the protective effect of BCG in adults is variable. The potential for revaccination with live vaccine is further limited by the rapid spread of HIV infection. The early-secreted Mycobacterium tuberculosis proteins have been used extensively in TB vaccine development, due to their high immunogenicity and have shown protective effect in animal models. The aim of our study was to evaluate the opportunity to increase the anti-TB resistance in experimental animals by re-vaccination with
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Capparelli, Rosanna, Francesco De Chiara, Nunzia Nocerino, et al. "Heterozygosity at the A625C Polymorphic Site of the MyD88 Gene Is Associated with Mycobacterium bovis Infection in Cattle." Infection and Immunity 81, no. 6 (2013): 2139–44. http://dx.doi.org/10.1128/iai.01398-12.

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ABSTRACTThe study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis (odds ratio [OR] = 0.19;P= 6 × 10−12). The reduced risk, however, does not extend to animals with latent pulmonary tuberculosis (OR = 0.83;P= 0.40). Heterozygosity at the A625C single nucleotide polymorphism is associated with intermediate levels of tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase (NOS). Accordingly, deficiency as well as overexpression of proinflammatory cytokines or NOS favor tuberculosi
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Trcka, I., J. Lamka, R. Suchy, et al. "Mycobacterial infections in European wild boar (Sus scrofa) in the CzechRepublic during the years 2002 to 2005." Veterinární Medicína 51, No. 5 (2012): 320–32. http://dx.doi.org/10.17221/5552-vetmed.

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A total of 842 wild boar of differing ages, originating from 29 (37.7%) of the 77 districts in the Czech Republic, were examined during the hunting seasons from 2002 to 2005. Of them, 274 (32.5%) of the animals were wild specimens and 568 (67.5%) from game parks. Out of 786 animals, the following were included in the study: 668 piglets, 61 juveniles, 32 adult males and 25 adult females. A total of 2 704 samples from various tissues and faeces were examined: 309 separately collected faecal samples from 309 (36.7%) animals, 2 332 samples from various tissues and 63 faecal sampl
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Kurtjak, B. M., V. M. Shevchuk, K. B. Suchomlin, et al. "Peculiarities of epizootological surveillance and control of mycobacteriosis in productive animals in the conditions of dairy farms of Ukraine." Animal Biology 26, no. 1 (2024): 17–23. http://dx.doi.org/10.15407/animbiol26.01.017.

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The increase in mycobacteriosis, an infectious disease caused by non-tuberculous mycobacteriosis, has become an urgent issue for humane medicine. The mycobacteriosis of animals is a subject of intense study by veterinary scientists across most countries globally. In Ukraine, the number of farms with productive animals exhibiting paraallergic reactions to tuberculin is steadily rising, making the diagnosis of tuberculosis more complicated. In dairy cattle breeding, this issue also has significant economic implications. The forced slaughter of breeding young stock and high-producing cows is ofte
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Lin, Philana Ling, Teresa Coleman, Jonathan P. J. Carney, et al. "Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens." Antimicrobial Agents and Chemotherapy 57, no. 9 (2013): 4237–44. http://dx.doi.org/10.1128/aac.00277-13.

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ABSTRACTTrials to test new drugs currently in development against tuberculosis in humans are impractical. All animal models to prioritize new regimens are imperfect, but nonhuman primates (NHPs) infected withMycobacterium tuberculosisdevelop active tuberculosis (TB) disease with a full spectrum of lesion types seen in humans. Serial 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) positron emission tomography (PET) with computed tomography (CT) imaging was performed on cynomolgus macaques during infection and chemotherapy with individual agents or the four-drug combination therapy most widely used globa
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JE, Shitaye, B. Getahun, T. Alemayehu, et al. "A prevalence study of bovine tuberculosis by using abattoir meat inspection and tuberculin skin testing data, histopathological and IS6110PCR examination of tissues with tuberculous lesions in cattle inEthiopia." Veterinární Medicína 51, No. 11 (2012): 512–22. http://dx.doi.org/10.17221/5585-vetmed.

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Post mortem surveillances, for the detection of tuberculous lesions in particular depend on the work load time and the diligence of the inspector conducting the examination. The first aim of the study was to determine the trend of occurrence of tuberculous lesions in two abattoirs in Addis Ababa and Debre-Zeit (Ethiopia). The second aim of the study was to determine prevalence of the tuberculin skin test results in 10 dairy farm areas in Addis Ababa. The third aim was to detect tuberculous lesions and causal agents from tissue samples of the respiratory tract and mesenteric lymph nodes of the
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Zavgorodniy, A. I., V. V. Bilushko, S. A. Pozmogova, M. V. Kalashnyk, and V. O. Busol. "Problems in the diagnosis of Bovine tuberculosis." Veterinary Medicine: inter-departmental subject scientific collection, no. 109 (September 27, 2023): 15–18. http://dx.doi.org/10.36016/vm-2023-109-3.

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The results of comprehensive researches in cattle-breeding farms of Ukraine to determine the epizootic situation of bovine tuberculosis are presented. It is proved that the application of the proposed complex of research methods allows to find out the causes of non-specific allergic reactions to tuberculin in animals with minimal economic losses for agricultural enterprises. It has been established that parallergic reactions to tuberculin in cattle are caused by such mycobacterial species as M. phlei, M. smegmatis, M. nonchromogenicum, and pseudoallergic reactions are caused by nocardia and ac
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BORHAM, M., A. OREIBY, A. EL-GEDAWY, Y. HEGAZY, and M. AL-GAABARY. "Tuberculin test errors and its effect on detection of bovine tuberculosis." Journal of the Hellenic Veterinary Medical Society 72, no. 4 (2022): 3263. http://dx.doi.org/10.12681/jhvms.29357.

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Bovine tuberculosis is an endemic disease in Egypt, a notable gap exists between limited cases identified by single intradermal tuberculin test performed through the national control program and higher detected cases at abattoirs. Therefore, this study aimed to investigate epidemiological situation and causes of the previously mentioned gap in Middle-Delta Region. A total of 25 emergency-slaughtered animals of unknown tuberculosis-status were investigated by cocktail-antigens ELISA and post-mortem examination. Five visible tuberculous-lesion cases were detected and confirmed by PCR, ELISA was
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Panarella, Matthew, and Sharon Hursh. "A retrospective analysis of the tuberculin skin test reactions of a single source population of Mauritian Macaca fascicularis held in quarantine during 2017." PLOS ONE 17, no. 4 (2022): e0265942. http://dx.doi.org/10.1371/journal.pone.0265942.

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A published range of reactions to the tuberculin skin test (TST) using mammalian (human) old tuberculin (MOT) in a population of Mauritius origin Macaca fascicularis in US laboratory animal medicine does not exist. The objectives of this report are to quantify the reactions among juvenile, adolescent, and male adult cynomolgus macaques and to provide the laboratory animal medicine practitioner with a reference range of reactions to MOT in Mauritian juvenile macaques. Monkeys in a US foreign animal quarantine must be tested negative for mycobacterial infection including Mycobacterium tuberculos
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Adji, R. S., H. Nuradji, and R. Dewiyanti. "Tuberculosis Cases Detection And Identification In Deer In Indonesia." IOP Conference Series: Earth and Environmental Science 1174, no. 1 (2023): 012019. http://dx.doi.org/10.1088/1755-1315/1174/1/012019.

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Abstract Tuberculosis is an chronic infectious disease in humans and animals caused by member from the Mycobacterium tuberculosis complex (MTBC). Deer are one of the animals that are susceptible to tuberculosis and as a reservoir of Myocobacterium bovis, but can also be infected by Mycobacterium tuberculosis. One sample each of organs, lungs and lymph nodes from a dead Timor deer (Cervus timorensis) was obtained from a zoo in West Java in 2021. The test was carried out by culture method using modified Ogawa media and multiplex polymerase chain reaction (PCR) for identification of growing bacte
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Ocepek, M., M. Pate, M. Zolnir-Dovc, and Z. Cvetnic. "Tuberculosis in cattle caused by IS901+ Mycobacterium avium subsp. avium – a case report." Veterinární Medicína 48, No. 1 - 2 (2012): 47–50. http://dx.doi.org/10.17221/5749-vetmed.

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In a small cattle herd an eight-year-old cow showed a reaction to bovine tuberculin in two consecutive skin tests. The animal showing clinical signs related to tuberculosis was slaughtered for diagnostic purpose. The lungs were completely covered with disseminate tubercles of different sizes and the mediastinal lymph nodes were enlarged. Pneumonia granulomatosa tuberculosa and lymphadenitis hyperplastica chronica were diagnosed histologically. Mycobacterium avium subsp. avium of IS901+ and IS1245+ genotype was isolated from lungs and from the lymph node. Six weeks after the affected animal has
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