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Relevant bibliographies by topics / Tuberculosis Mycobacterium tuberculosis Antibacterial activity

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Academic literature on the topic 'Tuberculosis Mycobacterium tuberculosis Antibacterial activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Tuberculosis Mycobacterium tuberculosis Antibacterial activity"

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Vaishnavi, P. Bansod, A. Katekar Vinayak, and Deshmukh Swati. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. https://doi.org/10.5281/zenodo.10609199.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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Zargarnezhad, Sarah, Ahmad Gholami, Mehdi Khoshneviszadeh, Seyedeh Narjes Abootalebi, and Younes Ghasemi. "Antimicrobial Activity of Isoniazid in Conjugation with Surface-Modified Magnetic Nanoparticles against Mycobacterium tuberculosis and Nonmycobacterial Microorganisms." Journal of Nanomaterials 2020 (August 11, 2020): 1–9. http://dx.doi.org/10.1155/2020/7372531.

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Isoniazid, the choice antitubercular agent, has only been employed against Mycobacterium tuberculosis. This study evaluated if the enzyme-mimetic activities of magnetic nanoparticles could accelerate the activation process of isoniazid against mycobacterial and, more importantly, non-mycobacterial microorganisms. First, magnetic nanoparticles were synthesized and coated by lipoamino acid; then, isoniazid was conjugated to synthesized nanoparticles. Antibacterial activities of nanoconjugated isoniazid were evaluated against Mycobacterium tuberculosis and four Gram-positive and Gram-negative non

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Annisa Dila Perwitasari, Lanny Mulqie, and Umi Yuniarni. "Aktivitas Antibakteri beberapa Tanaman dari Famili Asteraceae terhadap Bakteri Mycobacterium tuberculosis." Bandung Conference Series: Pharmacy 4, no. 2 (2024): 537–44. http://dx.doi.org/10.29313/bcsp.v4i2.14483.

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Abstract. Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis bacteria where one of the keys to successful treatment is adherence. There have been many in vitro studies conducted from Asteraceae plants that can be used to treat tuberculosis in several countries. This study aims to determine Asteraceae plants that have antibacterial activity against the growth of bacteria that cause tuberculosis. The research was conducted using the Systematic Literature Review (SLR) method using the keywords "antibacterial Mycobacterium tuberculosis, Asteraceae". The results obtai

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Istaufa, Fikriaddin Syafiq, Yoyok Subagio, Irma Suswati, and Isbandiyah. "Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis." Folia Medica Indonesiana 58, no. 4 (2022): 371–76. http://dx.doi.org/10.20473/fmi.v58i4.29307.

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Highlight : Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015. Castor plant leaf extract (Ricinus communis L.) has an antibacterial potential against the growth of Mycobacterium tuberculosis bacteria. Abstract: Mycobacterium tuberculosis is the cause of pulmonary tuberculosis that can reduce human health. In the therapy of the disease, patients can develop resistance to tuberculosis drugs. Based on the 2015 health profiles of Indonesia, 15,380 people were suspected to have multidrug-resistant tuberculosi

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Wang, Gaoyan, Wenqi Dong, Hao Lu, et al. "Enniatin A1, A Natural Compound with Bactericidal Activity against Mycobacterium tuberculosis In Vitro." Molecules 25, no. 1 (2019): 38. http://dx.doi.org/10.3390/molecules25010038.

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Background: Tuberculosis remains a global disease that poses a serious threat to human health, but there is lack of new and available anti-tuberculosis agents to prevent the emergence of drug-resistant strains. To address this problem natural products are still potential sources for the development of novel drugs. Methods: A whole-cell screening approach was utilized to obtain a natural compound enniatin A1 from a natural products library. The target compound’s antibacterial activity against Mycobacterium tuberculosis (M. tuberculosis) was evaluated by using the resazurin reduction micro-plate

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Vaishnavi P. Bansod, Vinayak A. Katekar, and Swati Deshmukh. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. http://dx.doi.org/10.30574/gscbps.2023.25.2.0433.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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Oleksijew, Andy, Jon Meulbroek, Patty Ewing, et al. "In Vivo Efficacy of ABT-255 against Drug-Sensitive and -Resistant Mycobacterium tuberculosisStrains." Antimicrobial Agents and Chemotherapy 42, no. 10 (1998): 2674–77. http://dx.doi.org/10.1128/aac.42.10.2674.

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ABSTRACT Current therapy for pulmonary tuberculosis involves 6 months of treatment with isoniazid, pyrazinamide, rifampin, and ethambutol or streptomycin for reliable treatment efficacy. The long treatment period increases the probability of noncompliance, leading to the generation of multidrug-resistant isolates of Mycobacterium tuberculosis. A treatment option that significantly shortened the course of therapy, or a new class of antibacterial effective against drug-resistant M. tuberculosis would be of value. ABT-255 is a novel 2-pyridone antibacterial agent which demonstrates in vitro poten

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Hoff, Donald R., Megan L. Caraway, Elizabeth J. Brooks, et al. "Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 52, no. 11 (2008): 4137–40. http://dx.doi.org/10.1128/aac.00196-08.

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ABSTRACT Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.

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Farr, Dylan C., Lendl Tan, Juanelle Furness, I. Darren Grice, Nicholas P. West, and Todd A. Houston. "Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin." Australian Journal of Chemistry 76, no. 11 (2023): 812–20. http://dx.doi.org/10.1071/ch23154.

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Aminoglycoside antibiotics represent the first class of successful drugs in the treatment of tuberculosis; however, mycobacteria and other bacterial species possess several drug resistance mechanisms to inactivate these natural products. In the past 15 years, a variety of amphiphilic aminoglycosides have been shown to have improved activity against infectious microorganisms and to subvert resistance mechanisms. Here, we report on four novel synthetic compounds derived from two existing potent antitubercular compounds and describe their activity against both Mycobacterium tuberculosis and Staph

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Maepa, Judas M., and Tlabo C. Leboho. "Benzylated Sulfamethoxazole Derivatives with Improved Safety Profile as Potential Anti-Mycobacterium tuberculosis and Antibacterial Agents." Journal of Chemistry 2023 (September 12, 2023): 1–12. http://dx.doi.org/10.1155/2023/4805466.

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This study focussed on the synthesis of sulfamethoxazole derivatives and their biological evaluation. The sulfamethoxazole derivatives were successfully biologically evaluated against Mycobacterium tuberculosis, Staphylococcus aureus, and Chinese Hamster Ovarian (CHO) cells. The biological evaluation revealed compounds with improved antitubercular activity and antibacterial activity against S. aureus as well as safety profile when compared to the starting material, sulfamethoxazole. The most active compounds against Mycobacterium tuberculosis were3q with 92% inhibition followed by 3s (90%), 3k

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Dissertations / Theses on the topic "Tuberculosis Mycobacterium tuberculosis Antibacterial activity"

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Leung, Oi-chi Anna, and 梁愛枝. "Molecular characterization of ofloxacin resistant mycobacterium tuberculosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B45010122.

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Martin, Constance Jean. "Efferocytosis is an Innate Antibacterial Mechanism of Mycobacterium tuberculosis Control." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10094.

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One third of the world’s population is infected with Mycobacterium tuberculosis, causing two million deaths annually. The bacteria avoid immune clearance by persisting within macrophages by subverting normal phagosome maturation and acidification. In order to spread, the bacteria induce necrotic death of its host macrophage, broadcasting the infection into neighboring cells. However, it has long been appreciated that the apoptotic, rather than necrotic death of an infected macrophage results in bacterial growth suppression, improved adaptive immune response and survival. The mechanism for apop

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Lau, Wing-tong Ricky, and 劉永棠. "Molecular characterization of fluoroquinolone resistance in mycobacterium tuberculosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47849654.

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The global emergence of drug resistance is posing increasing difficulties in the public health control and treatment of tuberculosis (TB). Fluoroquinolones (FQs) are regarded as having a pivotal role among the antimicrobial agents in multidrug regimens against multidrug-resistant tuberculosis (MDR-TB). Thus, early diagnosis of fluoroquinolone-resistant (FQr) MDR-TB and extensively drug-resistant tuberculosis (XDR-TB) by molecular tests has predictive value for the guidance of TB therapy. The pharmacokinetic (PK) and pharmacodynamic (PD) indices are valuable parameters to evaluate the

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Karkare, Shantanu. "Development of Mycobacterium tuberculosis DNA gyrase as a target for antibacterial chemotherapy." Thesis, University of East Anglia, 2010. https://ueaeprints.uea.ac.uk/25644/.

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Trower, Carolyn Joy 1975. "A preliminary investigation of a sialidase activity associated with M. smegmatis." Monash University, Dept. of Medicinal Chemistry, 2003. http://arrow.monash.edu.au/hdl/1959.1/7646.

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Afolayan, Omolola. "Discovery of antibacterial lead compounds from marine organisms." University of the Western Cape, 2020. http://hdl.handle.net/11394/7914.

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Philosophiae Doctor - PhD<br>Marine organisms including algae and bacteria are known to produce chemically diverse secondary metabolites for survival purposes in the marine environment. Scientists have identified some of these natural products as therapeutic agents including some antibiotics. Given the increase in the resistance of pathogenic microorganisms especially methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis to commonly prescribed antibiotics, researchers have turned towards exploiting marine natural products for new antibacterial compounds. Due to the

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Macingwana, Lubabalo. "Investigation of the activity of sulfonamide anti-bacterial drugs in Mycobacterium tuberculosis and the role of oxidative stress on the efficacy of these drugs." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86743.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Tuberculosis (TB) has become a global health epidemic affecting millions of people worldwide with a high incidence in third-world countries. The emergence of multi-drug and extremely-drug resistant M. tuberculosis strains together with the HIV/AIDS pandemic warrants the need for new drugs or new drug combinations. The folic acid synthesis pathway is one of the key pathways that are essential for the survival of bacteria in general. Sulfonamides are a group of compounds that target folic acid synthesis, particularly dihydro

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Mokgethi, Thabang. "The investigation of indigenous South African medicinal plants for activity against Mycobacterium tuberculosis." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/3434.

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Includes bibliographical references (leaves 109-122 ).<br>This study investigated four indigenous South African medicinal plants that are commonly used in traditional medicine for their bioactivity against Mycobacterium tuberculosis. Crude plant extracts were prepared and characterized using HPLC analysis. The crude rhizome extracts of Agapanthus praecox, leaf extracts of Olea europaea subsp.

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Man, Francis Alexandre Wei Ming. "Investigating the anti-inflammatory activity of a fragment of Chaperonin 60.1 derived from Mycobacterium tuberculosis." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-antiinammatory-activity-of-a-fragment-of-chaperonin-601-derived-from-mycobacterium-tuberculosis(0877ad17-bfb2-4223-a0a4-904589c39bf9).html.

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Chaperonin 60.1 (Cpn60.1) from Mycobacterium tuberculosis is a protein that has evolved from the traditional role of chaperone in protein folding to a role in extracellular signalling. While non-essential to the growth and survival of the bacteria, Cpn60.1 is essential to the formation of granuloma in tuberculosis [150]. Cpn60.1 has been shown to induce cytokine production in human monocytes [201], but also to prevent leukocyte migration in murine models of allergic lung inflammation [300]. Peptide 4, a fragment of Cpn60.1, has been shown to be responsible for the cytokineinducing activity of

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Ibrahim, Murad. "Evaluation of the bactericidal and sterilizing activity of diaryquinoline R207910 in murine model of tuberculosis." Paris 6, 2008. http://www.theses.fr/2008PA066168.

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Bases rationnelles: la tuberculose est à elle seule responsable d’environ 9 millions de nouveaux cas et de 1 à 2 millions de morts par an. Il existe pourtant un traitement antibiotique standard (recommandé par l’OMS) associant rifampicine, isoniazide, pyrazinamide et ethambutol (ou streptomycine), qui assure la guérison dans près de 95% des cas lorsqu’il est correctement suivi. Son efficacité est limité par sa longueur (au moins 6 mois), sa complexité (4 médicaments) et son inefficacité sur les souches multirésistantes. C’est pour outrepasser ces limites que de nouveaux antituberculeux sont né

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Book chapters on the topic "Tuberculosis Mycobacterium tuberculosis Antibacterial activity"

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Hendon-Dunn, Charlotte L., Saba Anwar, Christopher Burton, and Joanna Bacon. "Application of Continuous Culture for Assessing Antibiotic Activity Against Mycobacterium tuberculosis." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7638-6_6.

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Galoyan, Armen A. "Hypothalamic, Proline-Rich Polypeptide (Galarmin) has Protective and Immunogenic Activity on Experimental Mycobacterium Tuberculosis Infection." In Advances in Neurobiology. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3667-6_8.

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Moon, Christopher William, Eleanor Porges, Stephen Charles Taylor, and Joanna Bacon. "A Microtiter Plate Assay at Acidic pH to Identify Potentiators that Enhance Pyrazinamide Activity Against Mycobacterium tuberculosis." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3981-8_8.

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O’Brien, L., B. Roberts, and P. W. Andrew. "In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-80166-2_5.

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Garg, Ankita. "Analysis of Antimicrobial Activity of Monocytic Myeloid-Derived Suppressor Cells in Infection with Mycobacterium tuberculosis and Human Immunodeficiency Virus." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-1060-2_11.

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"Gold Complexes as Antibacterial Agents." In The Therapeutic Potential of Gold Complexes. Royal Society of Chemistry, 2025. https://doi.org/10.1039/9781837678891-00039.

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The exploration of the antibacterial properties of potassium dicyanidoaurate(i), K[Au(CN)2], against Mycobacterium tuberculosis prompted scientists to investigate gold complexes as antibacterial agents. As a result, several gold(i) and gold(iii) complexes based on different ligand systems have been reported, with exciting activities against a plethora of bacterial strains. This chapter describes the recent advances in the development of antibacterial gold(i) and gold(iii) complexes with activity against several bacterial species, such as methicillin-resistant Staphylococcus aureus, Enterococcu

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Minovski, Nikola, and Marjana Novič. "Integrated in Silico Methods for the Design and Optimization of Novel Drug Candidates." In Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment. IGI Global, 2015. http://dx.doi.org/10.4018/978-1-4666-8136-1.ch008.

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Although almost fully automated, the discovery of novel, effective, and safe drugs is still a long-term and highly expensive process. Consequently, the need for fleet, rational, and cost-efficient development of novel drugs is crucial, and nowadays the advanced in silico drug design methodologies seem to effectively meet these issues. The aim of this chapter is to provide a comprehensive overview of some of the current trends and advances in the in silico design of novel drug candidates with a special emphasis on 6-fluoroquinolone (6-FQ) antibacterials as potential novel Mycobacterium tubercul

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Phee, Lynette, and David Wareham. "Detecting Antimicrobial Resistance." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0056.

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● To optimize antimicrobial therapy for the management of individual patient’s infection. ● For surveillance purposes, which in turn inform local/national/international clinical guidelines. ● For the management of infection control and prevention. Broadly speaking, resistance is detected by observing its phenotypic expression (activity of the candidate drug(s) against the target bacterium) or detecting the underlying genotypic determinant (resistance genes). Commonly used methods in clinical diagnostic laboratories generally fall under the ‘phenotypic’ category. These share similar traits— eas

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Guzmán-Beltrán, Silvia, Fernando Hernández-Sánchez, and Omar M. Barrientos. "Natural Products with Antimicrobial Activity for Mycobacterium tuberculosis." In Frontiers in Anti-infective Agents. BENTHAM SCIENCE PUBLISHERS, 2020. http://dx.doi.org/10.2174/9789811469589120020004.

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Dian Novita, Bernadette, Ari Christy Mulyono, and Ferdinand Erwin. "Metformin for Tuberculosis Infection." In Metformin - Pharmacology and Drug Interactions. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99794.

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Tuberculosis, caused by Mycobacterium tuberculosis (M.tb), remains the biggest infection burden in the word. Rifampin (RIF) and Isoniazid (INH) are the most effective antibiotics for killing M.tb. However, the resistance rate of rifampin and INH are high and lead to almost 35% treatment failure. Metformin enhanced anti tuberculosis efficacy in killing M. tuberculosis through several mechanism, firstly through autophagia mechanism and secondly by activating superoxide dismutase (SOD). Metformin activated mTOR and AMPK then induced more effective autophagy against M.tb. Superoxide Dismutase (SOD

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Conference papers on the topic "Tuberculosis Mycobacterium tuberculosis Antibacterial activity"

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Niehaus, Katherine E., Timothy M. Walker, Derrick W. Crook, Tim E. A. Peto, and David A. Clifton. "Machine learning for the prediction of antibacterial susceptibility in Mycobacterium tuberculosis." In 2014 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI). IEEE, 2014. http://dx.doi.org/10.1109/bhi.2014.6864440.

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Guo, Lihui, Bente Hollestelle, Samantha A.M. Tromp, Annemiek Dijkhuis, and Rene Lutter. "Indoleamine 2,3-dioxygenase 1 (IDO1) activity arrests the apoptosis of Mycobacterium tuberculosis (M. tuberculosis)-infected macrophages." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa2469.

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Hwang, Sung Chul, Young Sun Kim, Yung Jung Jung, et al. "Microassay For Catalase Activity Of The Mycobacterium Tuberculosis From Clinical Isolates." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3349.

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Vaidya, Shashikant, Sukanya Sawant, and Jinesh Maniar. "Assessment of differential activity of reactive radicals in cell lines infected with Mycobacterium tuberculosis." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa4734.

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Fernandes, Guilherme, Paula Souza, Fernando Pavan, and Jean Dos Santos. "Synthesis and Anti-Mycobacterium tuberculosis Activity of N-oxide Containing Heterocycles." In 3rd International Electronic Conference on Medicinal Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04661.

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Amaral Neto, Antonio Serpa do, Eduarda Jaskulski, Eduardo Martins Leal, Matheus Marquardt, Gabriel de Deus Vieira, and Joana Capano Hawerroth. "Neurotuberculosis with intracerebral tuberculoma and PCR for detectable Mycobacterium in CSF." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.710.

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Introduction: Neurotuberculosis is the most serious form of extrapulmonary tuberculosis. The main clinical presentation is meningoencephalitis, which may be associated with tuberculomas. The detection of Mycobacterium tuberculosis by CSF in CSF is still a diagnostic challenge. Objectives: To report a clinical case of neurotuberculosis associated with intracranial tuberculoma with detection of Mycobacterium tuberculosis by CSF in CSF. Methods: Neurotuberculosis is the most serious form of extrapulmonary tuberculosis. The main clinical presentation is meningoencephalitis, which may be associated

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Alvarado-Huayhuaz, Jesus Antonio, Wilmar Puma-Zamora, and Ana Cecilia Valderrama-Negrón. "In-silico study of antituberculous activity of Zn-pyrazinamide in pyrazinamidase." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020-89.

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Tuberculosis is caused by Mycobacterium tuberculosis and is one of the leading causes of death. Treatment with pyrazinamide depends on the formation of the bioactive species, pyrazinoic acid (POA), catalyzed by the enzyme pyrazinamidase (PZAse). New mutant strains show resistance to PZA, therefore, it is necessary to search for new drugs. Metallodrugs can offer a synergistic effect on the biological activity of the metal and the drug. Recent studies by our group show anti-tuberculosis activity of pyrazinamide coordinated with Zn, however, the mechanism of action is unknown. In this work, an in

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Reports on the topic "Tuberculosis Mycobacterium tuberculosis Antibacterial activity"

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แก้วกิติณรงค์, กมล, та นิพนธ์ อุดมสันติสุข. บทบาทของ MAIT cells ในการควบคุมการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2016. https://doi.org/10.58837/chula.res.2016.28.

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วัณโรค (Tuberculosis) เป็นสาเหตุหลักของการเสียชีวิตจากโรคติดเชื้อของประชากรทั่วโลก (1) วัณโรคเกิดจากการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis ภูมิต้านทานของร่างกายที่มีต่อเชื้อ Mycobacterium tuberculosis ประกอบด้วยเซลล์จากส่วนของ innate immunity และ adaptive immunity ในส่วนของ adaptive immunity กลุ่มของ T cells ที่มีส่วนสำคัญ ได้แก่ ทั้ง conventional T cells (ทั้ง CD8+ และ CD4+) และ non-conventional T cells (MAIT, NKT, CD1-restricted T cells) (2) MAIT (Mucosal-associated invariant T) cells จัดอยู่ในกลุ่มของ non-conventional T cells ที่พบได้ปริมาณมากตามเยื่อบุของร่างกาย รวมถึงปอด (3) นอกจ

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