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Dissertations / Theses on the topic 'Tuberculosis Mycobacterium tuberculosis Antibacterial activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Leung, Oi-chi Anna, and 梁愛枝. "Molecular characterization of ofloxacin resistant mycobacterium tuberculosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B45010122.

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2

Martin, Constance Jean. "Efferocytosis is an Innate Antibacterial Mechanism of Mycobacterium tuberculosis Control." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10094.

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One third of the world’s population is infected with Mycobacterium tuberculosis, causing two million deaths annually. The bacteria avoid immune clearance by persisting within macrophages by subverting normal phagosome maturation and acidification. In order to spread, the bacteria induce necrotic death of its host macrophage, broadcasting the infection into neighboring cells. However, it has long been appreciated that the apoptotic, rather than necrotic death of an infected macrophage results in bacterial growth suppression, improved adaptive immune response and survival. The mechanism for apop

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3

Lau, Wing-tong Ricky, and 劉永棠. "Molecular characterization of fluoroquinolone resistance in mycobacterium tuberculosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47849654.

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The global emergence of drug resistance is posing increasing difficulties in the public health control and treatment of tuberculosis (TB). Fluoroquinolones (FQs) are regarded as having a pivotal role among the antimicrobial agents in multidrug regimens against multidrug-resistant tuberculosis (MDR-TB). Thus, early diagnosis of fluoroquinolone-resistant (FQr) MDR-TB and extensively drug-resistant tuberculosis (XDR-TB) by molecular tests has predictive value for the guidance of TB therapy. The pharmacokinetic (PK) and pharmacodynamic (PD) indices are valuable parameters to evaluate the

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4

Karkare, Shantanu. "Development of Mycobacterium tuberculosis DNA gyrase as a target for antibacterial chemotherapy." Thesis, University of East Anglia, 2010. https://ueaeprints.uea.ac.uk/25644/.

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5

Trower, Carolyn Joy 1975. "A preliminary investigation of a sialidase activity associated with M. smegmatis." Monash University, Dept. of Medicinal Chemistry, 2003. http://arrow.monash.edu.au/hdl/1959.1/7646.

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6

Afolayan, Omolola. "Discovery of antibacterial lead compounds from marine organisms." University of the Western Cape, 2020. http://hdl.handle.net/11394/7914.

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Philosophiae Doctor - PhD<br>Marine organisms including algae and bacteria are known to produce chemically diverse secondary metabolites for survival purposes in the marine environment. Scientists have identified some of these natural products as therapeutic agents including some antibiotics. Given the increase in the resistance of pathogenic microorganisms especially methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis to commonly prescribed antibiotics, researchers have turned towards exploiting marine natural products for new antibacterial compounds. Due to the

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7

Macingwana, Lubabalo. "Investigation of the activity of sulfonamide anti-bacterial drugs in Mycobacterium tuberculosis and the role of oxidative stress on the efficacy of these drugs." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86743.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Tuberculosis (TB) has become a global health epidemic affecting millions of people worldwide with a high incidence in third-world countries. The emergence of multi-drug and extremely-drug resistant M. tuberculosis strains together with the HIV/AIDS pandemic warrants the need for new drugs or new drug combinations. The folic acid synthesis pathway is one of the key pathways that are essential for the survival of bacteria in general. Sulfonamides are a group of compounds that target folic acid synthesis, particularly dihydro

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8

Mokgethi, Thabang. "The investigation of indigenous South African medicinal plants for activity against Mycobacterium tuberculosis." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/3434.

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Includes bibliographical references (leaves 109-122 ).<br>This study investigated four indigenous South African medicinal plants that are commonly used in traditional medicine for their bioactivity against Mycobacterium tuberculosis. Crude plant extracts were prepared and characterized using HPLC analysis. The crude rhizome extracts of Agapanthus praecox, leaf extracts of Olea europaea subsp.

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9

Man, Francis Alexandre Wei Ming. "Investigating the anti-inflammatory activity of a fragment of Chaperonin 60.1 derived from Mycobacterium tuberculosis." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-antiinammatory-activity-of-a-fragment-of-chaperonin-601-derived-from-mycobacterium-tuberculosis(0877ad17-bfb2-4223-a0a4-904589c39bf9).html.

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Chaperonin 60.1 (Cpn60.1) from Mycobacterium tuberculosis is a protein that has evolved from the traditional role of chaperone in protein folding to a role in extracellular signalling. While non-essential to the growth and survival of the bacteria, Cpn60.1 is essential to the formation of granuloma in tuberculosis [150]. Cpn60.1 has been shown to induce cytokine production in human monocytes [201], but also to prevent leukocyte migration in murine models of allergic lung inflammation [300]. Peptide 4, a fragment of Cpn60.1, has been shown to be responsible for the cytokineinducing activity of

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10

Ibrahim, Murad. "Evaluation of the bactericidal and sterilizing activity of diaryquinoline R207910 in murine model of tuberculosis." Paris 6, 2008. http://www.theses.fr/2008PA066168.

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Bases rationnelles: la tuberculose est à elle seule responsable d’environ 9 millions de nouveaux cas et de 1 à 2 millions de morts par an. Il existe pourtant un traitement antibiotique standard (recommandé par l’OMS) associant rifampicine, isoniazide, pyrazinamide et ethambutol (ou streptomycine), qui assure la guérison dans près de 95% des cas lorsqu’il est correctement suivi. Son efficacité est limité par sa longueur (au moins 6 mois), sa complexité (4 médicaments) et son inefficacité sur les souches multirésistantes. C’est pour outrepasser ces limites que de nouveaux antituberculeux sont né

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11

Pavan, Fernando Rogério [UNESP]. "Atividade anti - Mycobacterium tuberculosis intra e extracelular e citoxicidade dos complexos de rutênio e vanádio e seus ligantes." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/94811.

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Made available in DSpace on 2014-06-11T19:27:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-09Bitstream added on 2014-06-13T18:31:20Z : No. of bitstreams: 1 pavan_fr_me_arafcf.pdf: 465333 bytes, checksum: a257ef7f9c510b42345a93dc770ca838 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O Mycobacterium tuberculosis, principal agente da tuberculose (TB), é responsável pela morte anual de dois a três milhões de pessoas no mundo e por prejuízos econômicos globais de aproximadamente 12 b

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12

Khouri, Inana Marie. "Synthèse et évaluation biologique de composés de série pyranodibenzofurane actifs sur Mycobacterium Tuberculosis." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P633.

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La tuberculose est une maladie infectieuse extrêmement contagieuse qui dans sa forme simple peut être soignée et guérie. Cependant, des formes multirésistantes aux traitements classiques ont récemment fait leur apparition et le développement de nouvelles molécules constitue donc un enjeu majeur de santé publique. Le 3,3-diméthyl-1,2-dihydro-3H-benzofuro[3,2-f][1]benzopyrane est un produit possédant une activité antituberculeuse marquée, y compris sur des lignées résistantes. L’objectif des travaux réalisés ici est la recherche de composés de puissance accrue et l’élucidation du mécanisme d’act

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13

Solari, Lely, Alonso Soto, and der Stuyft Patrick Van. "Performance of clinical prediction rules for diagnosis of pleural tuberculosis in a high-incidence setting." John Wiley & Sons Ltd, 2017. http://hdl.handle.net/10757/622276.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.<br>Objectives: Diagnosis of pleural tuberculosis (PT) is still a challenge, particularly in resource-constrained settings. Alternative diagnostic tools are needed. We aimed at evaluating the utility of Clinical Prediction Rules (CPRs) for diagnosis of pleural tuberculosis in Peru. Methods: We identified CPRs for diagnosis of PT through a structured literature search. CPRs using high-complexity tests, as defined by the FDA, were excluded. We applie

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14

Oliveira, Carolina Gonçalves. "Síntese e caracterização de complexos de metais da primeira série do bloco d com tiossemicarbazonas para investigar seu potencial contra Mycobacterium tuberculosis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-30072013-091242/.

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Os casos de tuberculose vêm crescendo, coincidindo com o aumento dos casos de AIDS, sendo uma das doenças que causa maior número de mortes no mundo. Entretanto, a busca por novos fármacos cresce de forma lenta, principalmente pelo baixo interesse da indústria farmacêutica, uma vez que a tuberculose ocorre predominantemente em países em desenvolvimento. Tiossemicabazonas têm atraído a atenção de muitos pesquisadores por suas propriedades biológicas e farmacológicas. Esta classe de ligantes é biologicamente ativa contra Mycobacterium tuberculosis, agente causador da tuberculose. Este trabalho ap

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15

Pavan, Fernando Rogério. "Atividade anti - Mycobacterium tuberculosis intra e extracelular e citoxicidade dos complexos de rutênio e vanádio e seus ligantes /." Araraquara : [s.n.], 2009. http://hdl.handle.net/11449/94811.

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Resumo: O Mycobacterium tuberculosis, principal agente da tuberculose (TB), é responsável pela morte anual de dois a três milhões de pessoas no mundo e por prejuízos econômicos globais de aproximadamente 12 bilhões de dólares ao ano. Estima-se que 1/3 da população mundial esteja infectada com o bacilo na forma latente. Apesar disso, nenhuma nova droga específica contra o M. tuberculosis foi desenvolvida desde 1960. O presente trabalho objetivou a investigação do potencial anti-M. tuberculosis intra e extracelular juntamente com a citotoxicidade de 66 compostos envolvendo diferentes classes de

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16

Luckner, Sylvia Rosie. "Towards the development of high affinity InhA and KasA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis." kostenfrei, 2009. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2010/4362/.

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17

MARTINS, Marta Sofia Lopes. "The antimycobacterial activity of thioridazine derivatives against drug resistant Mycobacterium tuberculosis: in vitro, ex vivo and in vivo studies." Doctoral thesis, Instituto de Higiene e Medicina Tropical, 2008. http://hdl.handle.net/10362/61780.

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O objectivo principal desta tese foi o de avaliar a acção da tioridazina (TZ), bem como de compostos derivados desta, obtidos por manipulação química, como agentes com actividade contra Mycobacterium tuberculosis, em particular contra M. tuberculosis multi-resistente (MDR-TB). Desta forma foram obtidos vinte e dois derivados e efectuados testes de toxicidade e mutagenicidade pelo método de exclusão com azul de trypan (realizado em linfócitos humanos) e o teste de Ames, respectivamente. Todos os derivados não tóxicos e não mutagénicos foram testados in vitro contra estirpes de Staphylococcus

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18

Mothiba, Maborwa Tebogo. "The effects of clofazimine on mycobacterium smegmatis biofilm formation." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/31569.

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Chemotherapy of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M. tuberculosis), is successful against actively-growing bacilli but ineffective against dormant/persistent organisms, found mainly in a protective lipid-laden granuloma, possibly necessitating the use of lipophilic antibiotics. In vitro, these bacilli are encased in lipid-rich biofilms. In this study, the antimycobacterial activity of one such agent, clofazimine, and its nanoparticle formulation, have been investigated against Mycobacterium smegmatis (M. smegmatis), as a surrogate for M. tuberculosis, by determ

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19

Van, Rensburg Lyne. "Antimycobacterial agents : a study of Liposomal-Encapsulation, comparitive permeability of bronchial tissue and in vitro activity against mycobacterium tuberculosis isolates." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71868.

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Thesis (MScMedSc)--Stellenbosch University, 2012.<br>Includes bibliography<br>ENGLISH ABSTRACT: In this thesis, research results are reported on the role of dipalmitoyl phosphatidyl choline (DPPC) and DPPC-liposomes on the in vitro permeability characteristics of various antimycobacterial drugs across porcine bronchial tissue. The permeability flux values of the different compounds (isoniazid, ofloxacin and moxifloxacin) and their relevant DPPC formulations were determined using a continuous flow through perfusion system. Mean steady state flux values were compared statistically by means of a

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20

Khor, Siew Yan. "The immunomodulating activity of levamisole and gamma-interferon on experimental murine infections with Mycobacterium microti and Mycobacterium tuberculosis and the influence of gamma-interferon on the bactericidal activity of Isoniazid and Rifampicin." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37744.

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21

MARTINS, Ana Sofia Fernandes. "Activity of compounds isolated from Carpobrotus edulis on efflux pumps of bacteria and cancer cells." Doctoral thesis, Instituto de Higiene e Medicina Tropical, 2010. http://hdl.handle.net/10362/64690.

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Introdução: A resistência aos antibióticos é um grave problema de saúde quer em Portugal quer a nível mundial. Nos dias de hoje, uma grande percentagem dos isolados clínicos de bactérias Gram-negativas é multi-resistente (MR) e, sempre que estudado, o fenótipo MR é mediado pela sobre-expressão de bombas de efluxo (BE). A sobre-expressão de bombas de efluxo em bactérias resulta da exposição destas a um antibiótico que, por vários processos, lhes confere um fenótipo MR. Contudo, o processo pelo qual a estirpe bacteriana desenvolve resistência durante a terapia com determinado antibiótico, ainda

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22

Gröner, Yvonne [Verfasser], Rainer [Akademischer Betreuer] Kalscheuer, Rainer [Gutachter] Kalscheuer, and Peter [Gutachter] Proksch. "Functional characterization of the antimicrobial activity of synthetic callyaerins against Mycobacterium tuberculosis / Yvonne Gröner ; Gutachter: Rainer Kalscheuer, Peter Proksch ; Betreuer: Rainer Kalscheuer." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1239451997/34.

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23

Shauli, Mathulo Mathabiso. "Histopathology induced by a medicinal plant indigenous to South Africa that has shown in vitro anti-microbial activity against drug resistant strains of Mycobacterium tuberculosis." Thesis, Nelson Mandela Metropolitan University, 2015. http://hdl.handle.net/10948/3990.

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Tuberculosis (TB) still remains a health problem globally with over a million new infections and a mortality rate of 1.5 million individuals annually (Hawn et al., 2014). The emerging multi-drug resistant (MDR) strains that accompany human immune deficiency virus (HIV) infection in high-incidence populations contribute significantly to the health burden of TB (Areeshi et al., 2014). The standard treatment that is advocated by the World Health Organization (WHO) for active tuberculosis includes long-term therapy that incorporates the use of isoniazid, rifampicin, pyrazinimide and ethambutol as

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24

Rey, Jurado Emma. "Virulence of drug-resistant Mycobacterium tuberculosis and activity of drug combinations against drug-resistant and drug-susceptible isolates in ex-vivo and in vitro models." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/107758.

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Tuberculosis (TB) remains a global threat worldwide with nearly nine million incident cases of TB. The emergence of M. tuberculosis resistance to antituberculous drugs has led to the need for careful TB surveillance and control. Further knowledge of drug-resistant M. tuberculosis plays an important role in avoiding TB transmission as well as designing more efficient schedules of treatment. The objectives were: 1) to analyse of clinical isolates of Mycobacterium tuberculosis resistant to antituberculous drugs to penetrate and grow within murine macrophages compared with drug-susceptible iso

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Prieri, Marion. "Reprogrammation de la bioactivation de prodrogues antituberculeuses : conception, synthèse et évaluation biologique de molécules bioactivables selon différents mécanismes oxydatifs et de composés potentialisant l’activité de nitro-imidazolés." Thesis, Lille, 2018. http://www.theses.fr/2018LILUS056.

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Depuis deux décennies, l’humanité est confrontée à une augmentation spectaculaire du nombre de bactéries résistantes et multirésistantes aux antibiotiques, mettant en péril l’arsenal thérapeutique au complet. La tuberculose est particulièrement concernée par l’apparition de souches multirésistantes aux antibiotiques, obligeant très souvent les médecins à prolonger de plusieurs mois la prise en charge des patients et à jongler avec différents antibiotiques en cours de traitement, ce qui retarde d’autant plus la guérison. En outre, si les souches pan-résistantes restent, pour le moment, exceptio

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26

Raphoko, Lerato Augustinah. "Synthesis of quinoxaline compounds and their medicinal properties against mycobacterium tuberculosis." Thesis, 2019. http://hdl.handle.net/10386/3377.

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Thesis (M.Sc. (Chemistry)) -- University of Limpopo, 2020<br>In an attempt to synthesise quinoxaline-ferrocene compounds with antimycobacterial activity; a series of quinoxaline alkynyl derivatives were successfully synthesised from 3- (quinoxalin-3-yl)prop-2-yn-1-ol 86A and 3-(6-chloroquinoxalin-2-yl)prop-2-yn-1-ol 86B. In this series compounds 87A – B, 90A – B, and 93A – C were intermediates obtained in an effort to synthesise quinoxaline-ferrocene compounds. Treatment of either 86A or 86B with various acid chlorides afforded quinoxaline alkynyl ester derivatives 97A - 97B. Within

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27

ZENARO, Elena. "Modulation of human dendritic cells funtional activity by M. tuberculosis." Doctoral thesis, 2009. http://hdl.handle.net/11562/337333.

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Mycobacterium tuberculosis (Mtb) è in grado di interferire sulle funzionalità delle cellule dendritiche (DC) e quindi di influenzare la risposta acquisita dei linfociti T. In questa tesi noi mostriamo che Mtb è in grado di alterare il differenziamento dei monociti a DC con la formazione di cellule esprimenti alti livelli di CD14 e bassi livelli di CD1a e CD1c. Queste cellule sono in grado di produrre TNF-α così come piccole quantità di IL-1β, IL-6 e IL-23, ma non secernono misurabili quantità di IL-12 nei sopranatanti di coltura. Probabilmente da questa incapacità di secernere citochine deriva

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Mujovo, Silva Fabiao. "Antimicrobial activity of compounds isolated from Lippia javanica (Burm.f.) Spreng and Hoslundia opposita against Mycobacterium tuberculosis and HIV-1 reverse transcriptase /." 2009. http://upetd.up.ac.za/thesis/available/etd-06042010-005807.

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Mujovo, Silva Fabiao. "Antimicrobial activity of compounds isolated from Lippia javanica (Burm.f.) Spreng and Hoslundia opposita against Mycobacterium tuberculosis and HIV-1 reverse transcriptase." Thesis, 2010. http://hdl.handle.net/2263/25246.

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For centuries medicinal plants have been used all over the world for the treatment and prevention of various ailments, particularly in developing countries where infectious diseases are endemic and modern health facilities and services are inadequate. In recent years the use of and search for drugs derived from plants have been accelerated. Ethnopharmacologists, botanists, microbiologists, and natural-product chemists are trying to discover phytochemicals and “leads” which could be developed for the treatment of infectious diseases. Plants are rich in a wide variety of secondary metabolites, s

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Araújo, Hugo Alexandre Almeida Quaresma de Albuquerque. "Pharmaceutical Ionic Liquids as an Effective Treatment against Mycobacterium tuberculosis." Master's thesis, 2022. http://hdl.handle.net/10362/134443.

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Tuberculosis (TB) is still today considered the major cause of death by infectious diseases in adults at the global scale. According to the WHO, 10.4 million cases of the disease were active in 2016, among which 1.6 million resulted in death. Over the last years, TB was mainly fought by resorting to the combination of several 1st and 2nd generation drugs, including rifampicin, ethambutol and isoniazid. However, such treatment regime is frequently ineffective to combat TB particularly for multi-resistant Mycobacterium tuberculosis cases. In this work, ethambutol (ETB) was selected as anti-TB dr

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Campbell, Lisa. "Recombinant production and activity assessment of growth stimulatory proteins in the resuscitation of mycobacterium tuberculosis." Thesis, 2020. https://hdl.handle.net/10539/29996.

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A dissertation submitted in fulfilment of the requirements for the degree of Master of Science in Medicine to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2020<br>Mycobacterium tuberculosis (Mtb) is able to enter a non-culturable, dormant-like, state under stressful conditions to evade eradication. When growth permissive conditions resume, Mtb can exit this non-culturable state and resume active replication. Non-culturable populations are of great interest in clinical settings as they can contribute to misdiagnoses and inaccurate treatment monitoring. Resuscit

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Nautiyal, Astha. "Understanding the Mechanism of Homologous Recombination in Mycobacterium Tuberculosis : Exploring RecA as an Antibacterial Target and Characterization of Holliday Junction Resolvases." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3986.

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Homologous recombination (HR) is conserved across all three domains of life and is associated with a number of key biological processes. Over the years, numerous genetic, biochemical and structural studies have uncovered important mechanistic details and established a role for HR in DNA damage repair, control of DNA replication fidelity and suppression of various types of cancer. Much of our current understanding of the mechanistic aspects of HR is gained from the study of Escherichia coli paradigm. E. coli RecA is the founding member of a nearly ubiquitous family of multifunctional proteins a

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Nautiyal, Astha. "Understanding the Mechanism of Homologous Recombination in Mycobacterium Tuberculosis : Exploring RecA as an Antibacterial Target and Characterization of Holliday Junction Resolvases." Thesis, 2015. http://etd.iisc.ernet.in/2005/3926.

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Homologous recombination (HR) is conserved across all three domains of life and is associated with a number of key biological processes. Over the years, numerous genetic, biochemical and structural studies have uncovered important mechanistic details and established a role for HR in DNA damage repair, control of DNA replication fidelity and suppression of various types of cancer. Much of our current understanding of the mechanistic aspects of HR is gained from the study of Escherichia coli paradigm. E. coli RecA is the founding member of a nearly ubiquitous family of multifunctional proteins a

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34

Van, der Kooy Frank. "The medicinal and chemical aspects of naphthoquinones isolated from Euclea natalensis A. DC. on Mycobacterium tuberculosis." Thesis, 2007. http://hdl.handle.net/2263/25601.

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The isolation and antimycobacterial activity of several naphthoquinones from Euclea natalensis were previously reported and initiated this study into the occurrence, chemistry and biological activity of this class of compounds. The structure activity relationship of the isolated naphthoquinones, and commercially available derivatives were also studied. Several plant species were investigated to establish a possible link between their traditional use for chest related symptoms (including tuberculosis infection) and the occurrence of 7-methyljuglone in these plants. The plants were extracted and

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35

Luckner, Sylvia. "Towards the development of high affinity InhA and KasA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis." Doctoral thesis, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-43621.

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Mycobacterium tuberculosis is the causative agent of tuberculosis and responsible for more than eight million new infections and about two million deaths each year. Novel chemotherapeutics are urgently needed to treat the emerging threat of multi drug resistant and extensively drug resistant strains. Cell wall biosynthesis is a widely used target for chemotherapeutic intervention in bacterial infections. In mycobacteria, the cell wall is comprised of mycolic acids, very long chain fatty acids that provide protection and allow the bacteria to persist in the human macrophage. The type II fatty a

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Chen, Tsan-Jan, and 陳粲然. "Structure-activity Investigation of Shikimate Pathway Enzymes from Helicobacter pylori and Mycobacterium tuberculosis : Shikimate Dehydrogenase and 3-Dehydroquinate Synthase." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/38072780125000829360.

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Barichievy, Samantha. "Mutation rates in mycobacterial hosts with altered Dna metabolic activity." Thesis, 2006. http://hdl.handle.net/10539/163.

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Master of Science - Molecular Medicine and Haematology<br>The completion of the genome sequence of Mycobacterium tuberculosis strain H37Rv revealed that 10% of the coding capacity is devoted to two, large multigene families that are characterised by repeat sequences. These are the PE and PPE families that code for acidic, glycine rich proteins. A subgroup of the PE family is the polymorphic GC rich sequence (PGRS) gene subfamily. Genome comparisons of clinical isolates of M. tuberculosis have confirmed the polymorphic character of some of these genes suggesting they may be analogous to the con

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Luckner, Sylvia Rosie [Verfasser]. "Towards the development of high affinity InhA and KasA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis = Entwicklung von hoch-affinen InhA- und KasA-Inhibitoren gegen resistente Stämme von Mycobacterium tuberculosis / submitted by Sylvia Rosie Luckner." 2009. http://d-nb.info/999715712/34.

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Andrade, Joana Eulália da Cruz Marçalo de. "Unravelling new ethnopharmacological roles of Plectranthus species: biological activity screening." Master's thesis, 2016. http://hdl.handle.net/10451/34349.

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Tese de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>This dissertation focused on the biological activity screening of several Plectranthus spp. plants, aiming to unravell novel ethnopharmacological roles and further research, of several extracts (methanol, ethyl acetate, acetone and water) and isolated compounds. Previous evidences on interesting biological activities of Plectranthus spp. constituents, directed the study for antioxidant, anti-skin ageing, anti-inflammatory, and anti-mycobacterial activities. Antioxidant results revealed an incre

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Chiu, Feng-Yu, and 邱夆昱. "(I) Synthesis of benzimidazole linked indoline derivative by acid catalyst(II) One-pot synthesis of derivative of ellipticine which has the activity against Mycobacterium tuberculosis." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/3snnw5.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>105<br>This thesis has two parts: The first part is about synthesis of benzimidazole linked indoline derivatives from C-2-linked-o-aminobenzyl benzimidazole by acid catalyst. This method can apply to various funtional groups. There is no published paper refer to benzimidazole linked indoline derivatives, so we hope these heterobicyclic molecules can show more bioactivity and also hope this thesis can open a new page for research of drugs. The second part is about One-pot synthesis of derivative of ellipticine which has the activity against Mycobacterium tuberculosi

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Mire, Joseph Andrew. "Application of Structure Activity Relationships of the Mycobacterium Tuberculosis Beta-Lactamase (BlaC) and the New Delhi Metallo-Beta-Lactamase (NDM-1) to Combating Beta-Lactamase Mediated Drug Resistance." Thesis, 2013. http://hdl.handle.net/1969.1/151238.

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β-lactamase enzymes catalyze the irreversible hydrolysis of the four-membered cyclic amide ring characteristic of β-lactam antibiotics rendering them inactive and useless against pathogenic bacteria. Understanding structure activity relationships between β-lactam antibiotics and β-lactamases is important for designing novel β-lactams, β-lactamase inhibitors, and β-lactam-based fluorescent probes for rapid diagnosis of β-lactam antibiotic resistant infections. The first half of this study focuses on the class A β-lactamase BlaC from Mycobacterium tuberculosis (Mtb) and addresses intermolecula

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Chen, Yen Ling, and 陳姸伶. "Biological functions of cis- and trans-cinnamic acid(I) Inhibition on invasion and metastasis of human lung carcinoma cells(II) Antituberculosis and synergistic activity on multiple- drug resistant Mycobacterium tuberculosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/64360908958058183749.

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碩士<br>台南應用科技大學<br>生活應用科學研究所<br>100<br>Biological functions of cis- and trans-cinnamic acid (I) Inhibition on invasion and metastasis of human lung carcinoma cells 　　Cinnamic acid (3-phenyl-2-propenoic acid, CA) is a natural compound with several isomers that presented in various plant derived foods, and trans-cinnamic acid (trans-CA) is the predominant form. Although numerous pharmacological effects of trans-CA, such as anti-inflammation, anti-oxidation, and anti-cancer, have been found, cis-cinnamic acid (cis-CA) is considered possesses a higher physiological activity than trans-CA.　Lung can

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Chiang, Yu Ling, and 蔣裕玲. "Bioactivity of active ingredient in dietary seasonings --Rosmarinic acid(I)Inhibition on invasive activity of human colorectal carcinoma cells(II)Inhibitory effect and mechanism on multiple-drug resistant Mycobacterium tuberculosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/81873134553699820316.

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碩士<br>台南應用科技大學<br>生活應用科學研究所<br>100<br>(I) Colorectal cancer is the leading cause of cancer mortality, and metastasis is responsible for approximately 40% of death in colon cancer patients. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and MMP-2 and -9 are critical for cell migration leading to invasion and metastasis of cancer. The inhibition of MMP-2 and -9 is therefore considered that might depress the occurrence of tumor invasion and metastasis. Rosmarinic acid (RA) is a bioactive polyphenol that widely presented in Rosmarinus officinalis L.

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Chiang, Yu-Ling, and 蔣裕玲. "Bioactivity of active ingredient in dietary seasonings --Rosmarinic acid(I) Inhibition on invasive activity of human colorectal carcinoma cells(II) Inhibitory effect and mechanism on multiple-drug resistant Mycobacterium tuberculosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/35663803510360707953.

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碩士<br>台南應用科技大學<br>生活應用科學研究所<br>100<br>(I) Colorectal cancer is the leading cause of cancer mortality, and metastasis is responsible for approximately 40% of death in colon cancer patients. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and MMP-2 and -9 are critical for cell migration leading to invasion and metastasis of cancer. The inhibition of MMP-2 and -9 is therefore considered that might depress the occurrence of tumor invasion and metastasis. Rosmarinic acid (RA) is a bioactive polyphenol that widely presented in Rosmarinus officinalis L.

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