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Journal articles on the topic 'Tuberculosis Mycobacterium tuberculosis Antibacterial activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Vaishnavi, P. Bansod, A. Katekar Vinayak, and Deshmukh Swati. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. https://doi.org/10.5281/zenodo.10609199.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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2

Zargarnezhad, Sarah, Ahmad Gholami, Mehdi Khoshneviszadeh, Seyedeh Narjes Abootalebi, and Younes Ghasemi. "Antimicrobial Activity of Isoniazid in Conjugation with Surface-Modified Magnetic Nanoparticles against Mycobacterium tuberculosis and Nonmycobacterial Microorganisms." Journal of Nanomaterials 2020 (August 11, 2020): 1–9. http://dx.doi.org/10.1155/2020/7372531.

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Isoniazid, the choice antitubercular agent, has only been employed against Mycobacterium tuberculosis. This study evaluated if the enzyme-mimetic activities of magnetic nanoparticles could accelerate the activation process of isoniazid against mycobacterial and, more importantly, non-mycobacterial microorganisms. First, magnetic nanoparticles were synthesized and coated by lipoamino acid; then, isoniazid was conjugated to synthesized nanoparticles. Antibacterial activities of nanoconjugated isoniazid were evaluated against Mycobacterium tuberculosis and four Gram-positive and Gram-negative non

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3

Annisa Dila Perwitasari, Lanny Mulqie, and Umi Yuniarni. "Aktivitas Antibakteri beberapa Tanaman dari Famili Asteraceae terhadap Bakteri Mycobacterium tuberculosis." Bandung Conference Series: Pharmacy 4, no. 2 (2024): 537–44. http://dx.doi.org/10.29313/bcsp.v4i2.14483.

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Abstract. Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis bacteria where one of the keys to successful treatment is adherence. There have been many in vitro studies conducted from Asteraceae plants that can be used to treat tuberculosis in several countries. This study aims to determine Asteraceae plants that have antibacterial activity against the growth of bacteria that cause tuberculosis. The research was conducted using the Systematic Literature Review (SLR) method using the keywords "antibacterial Mycobacterium tuberculosis, Asteraceae". The results obtai

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Istaufa, Fikriaddin Syafiq, Yoyok Subagio, Irma Suswati, and Isbandiyah. "Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis." Folia Medica Indonesiana 58, no. 4 (2022): 371–76. http://dx.doi.org/10.20473/fmi.v58i4.29307.

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Highlight : Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015. Castor plant leaf extract (Ricinus communis L.) has an antibacterial potential against the growth of Mycobacterium tuberculosis bacteria. Abstract: Mycobacterium tuberculosis is the cause of pulmonary tuberculosis that can reduce human health. In the therapy of the disease, patients can develop resistance to tuberculosis drugs. Based on the 2015 health profiles of Indonesia, 15,380 people were suspected to have multidrug-resistant tuberculosi

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Wang, Gaoyan, Wenqi Dong, Hao Lu, et al. "Enniatin A1, A Natural Compound with Bactericidal Activity against Mycobacterium tuberculosis In Vitro." Molecules 25, no. 1 (2019): 38. http://dx.doi.org/10.3390/molecules25010038.

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Background: Tuberculosis remains a global disease that poses a serious threat to human health, but there is lack of new and available anti-tuberculosis agents to prevent the emergence of drug-resistant strains. To address this problem natural products are still potential sources for the development of novel drugs. Methods: A whole-cell screening approach was utilized to obtain a natural compound enniatin A1 from a natural products library. The target compound’s antibacterial activity against Mycobacterium tuberculosis (M. tuberculosis) was evaluated by using the resazurin reduction micro-plate

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Vaishnavi P. Bansod, Vinayak A. Katekar, and Swati Deshmukh. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. http://dx.doi.org/10.30574/gscbps.2023.25.2.0433.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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Oleksijew, Andy, Jon Meulbroek, Patty Ewing, et al. "In Vivo Efficacy of ABT-255 against Drug-Sensitive and -Resistant Mycobacterium tuberculosisStrains." Antimicrobial Agents and Chemotherapy 42, no. 10 (1998): 2674–77. http://dx.doi.org/10.1128/aac.42.10.2674.

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ABSTRACT Current therapy for pulmonary tuberculosis involves 6 months of treatment with isoniazid, pyrazinamide, rifampin, and ethambutol or streptomycin for reliable treatment efficacy. The long treatment period increases the probability of noncompliance, leading to the generation of multidrug-resistant isolates of Mycobacterium tuberculosis. A treatment option that significantly shortened the course of therapy, or a new class of antibacterial effective against drug-resistant M. tuberculosis would be of value. ABT-255 is a novel 2-pyridone antibacterial agent which demonstrates in vitro poten

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Hoff, Donald R., Megan L. Caraway, Elizabeth J. Brooks, et al. "Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 52, no. 11 (2008): 4137–40. http://dx.doi.org/10.1128/aac.00196-08.

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ABSTRACT Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.

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9

Farr, Dylan C., Lendl Tan, Juanelle Furness, I. Darren Grice, Nicholas P. West, and Todd A. Houston. "Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin." Australian Journal of Chemistry 76, no. 11 (2023): 812–20. http://dx.doi.org/10.1071/ch23154.

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Aminoglycoside antibiotics represent the first class of successful drugs in the treatment of tuberculosis; however, mycobacteria and other bacterial species possess several drug resistance mechanisms to inactivate these natural products. In the past 15 years, a variety of amphiphilic aminoglycosides have been shown to have improved activity against infectious microorganisms and to subvert resistance mechanisms. Here, we report on four novel synthetic compounds derived from two existing potent antitubercular compounds and describe their activity against both Mycobacterium tuberculosis and Staph

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Maepa, Judas M., and Tlabo C. Leboho. "Benzylated Sulfamethoxazole Derivatives with Improved Safety Profile as Potential Anti-Mycobacterium tuberculosis and Antibacterial Agents." Journal of Chemistry 2023 (September 12, 2023): 1–12. http://dx.doi.org/10.1155/2023/4805466.

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This study focussed on the synthesis of sulfamethoxazole derivatives and their biological evaluation. The sulfamethoxazole derivatives were successfully biologically evaluated against Mycobacterium tuberculosis, Staphylococcus aureus, and Chinese Hamster Ovarian (CHO) cells. The biological evaluation revealed compounds with improved antitubercular activity and antibacterial activity against S. aureus as well as safety profile when compared to the starting material, sulfamethoxazole. The most active compounds against Mycobacterium tuberculosis were3q with 92% inhibition followed by 3s (90%), 3k

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Irianti, Tatang, Sylvia Utami Tanjung Pratiwi, and Intan Farida Yasmin. "Antituberculosis Activity of Active Compound of Ethyl Acetate Extract for Patikan Kebo (Euphorbia hirta L.)." Jordan Journal of Pharmaceutical Sciences 15, no. 4 (2022): 461–73. http://dx.doi.org/10.35516/jjps.v15i4.671.

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Infectious diseases caused by bacteria are a concern in the world of health. The microbe Mycobacterium tuberculosis which causes tuberculosis (TB) is one of the main disease problems in the world, as evidenced by the existence of 10.4 million sufferers and 1.8 million deaths in the world in 2015. During 5 years (2015 to 2020), the World Health Organization was done some comprehensive programs it can reduce mortality up to 13%. However, since early 2020 were increased the mortality rate again as in 2015. In addition, the increasing incidence of bacterial resistance to antibiotics has triggered

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12

Pallabothula, Vinod Sukanth Kumar, Marek Kerda, Martin Juhás, et al. "Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity." Biomolecules 12, no. 11 (2022): 1561. http://dx.doi.org/10.3390/biom12111561.

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Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly required. This study presents the design, synthesis, and biological evaluation of 3-acylaminopyrazine-2-carboxamides derived from a previously reported inhibitor of human prolyl-tRNA synthetase. Compounds were evaluated in vitro against various strains of mycobacteria, pathogenic bacteria, and fungi of clinical significance. In general, high activity aga

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Safiullah Ghori, Syed, Rahemeen Bano, Mohammed Muaaz Ahmed, et al. "Comparison Between Dynamic Neuromuscular Stabilization Breathing Exercises and Pilates Exercises in Young Overweight Individuals with Activity-Related Breathlessness." Journal of Neonatal Surgery 14, no. 5S (2025): 917–22. https://doi.org/10.52783/jns.v14.2191.

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Background: Tuberculosis is an ancient scourge. It has plagued humankind throughout known history and human pre-history. Mycobacterium tuberculosis have killed more persons than any other microbial pathogen [1]. Although the thorax is most frequently involved, tuberculosis may involve any of a number of organ systems like the respiratory, cardiac, central nervous system, musculoskeletal, gastrointestinal, and genitourinary systems and timely diagnosis of the disease is paramount, since delayed treatment is associated with severe morbidity [2].Thus the antibacterial properties of Rifamycin, 8-(

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14

Khandazhinskaya, Anastasia, Liudmila Alexandrova, Elena Matyugina, et al. "Novel 5′-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents." Molecules 23, no. 12 (2018): 3069. http://dx.doi.org/10.3390/molecules23123069.

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A series of novel 5′-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of Mycobacterium smegmatis was completely inhibited by the most active compounds at a MIC99 of 67 μg/mL (mc2155) and a MIC99 of 6.7–67 μg/mL (VKPM Ac 1339). Several compounds also showed the ability to inhibit the growth of attenuated strains of Mycobacterium tuberculosis ATCC 25177 (MIC99 28–61 μg/mL) and Mycobacterium bovis ATCC 35737 (MIC99 50–60 μg/mL), as well as tw

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15

Subnesh, Kumar Jain, B. Puranik Sangamesh, Saraswat Rohit, Jhajharia Mahesh, and Sharma Ritu. "Synthesis and Evaluation of the Diaminoquinazoline Series as Anti-Tubercular Agents." International Multispeciality Journal of Health 6, no. 7 (2020): 25–38. https://doi.org/10.5281/zenodo.4095244.

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<strong>Abstract</strong><strong>—</strong> The 2,4-diaminoquinazoline class of compounds has previously been identified as an effective inhibitor of Mycobacterium tuberculosis growth. We conducted an extensive evaluation of the series for its potential as a lead candidate for tuberculosis drug discovery. Three segments of the representative molecule N-(4-fluorobenzyl)-2-(piperidin-1-yl) quinazolin-4-amine were examined systematically to explore structure–activity relationships influencing potency. We determined that the benzylic amine at the 4-position, the piperidine at 2-positio

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Setiawan, Iwang Davi, Muhammad Reza Putra Mahardika, Aditya Wardhana, and Sista Werdyani. "The potential of several compounds in Peperomia pellucida as a solution to rifampicin resistance in tuberculosis disease." Jurnal Ilmiah Farmasi 19, no. 2 (2023): 232–42. http://dx.doi.org/10.20885/jif.vol19.iss2.art20.

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Background: Tuberculosis is a lung disease caused by Mycobacterium tuberculosis. In 2018, the incidence of tuberculosis in Indonesia was 1,017,290. The number of cases was accompanied by an increase in the number of resistances to first-line antibiotics (rifampicin) used due to patient non-compliance as well as the long duration of treatment. The increase in resistance around the world is always increasing every year by about 2%. Therefore, we need another alternative to existing plants in Indonesia that has the potential to be a solution to the problem and overcome resistance to these treatme

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17

Guzmán-Beltrán, Silvia, Esmeralda Juárez, Brenda L. Cruz-Muñoz, Cesar A. Páez-Cisneros, Carmen Sarabia, and Yolanda González. "Bactericidal Permeability-Increasing Protein (BPI) Inhibits Mycobacterium tuberculosis Growth." Biomolecules 14, no. 4 (2024): 475. http://dx.doi.org/10.3390/biom14040475.

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Bactericidal permeability-increasing protein (BPI) is a multifunctional cationic protein produced by neutrophils, eosinophils, fibroblasts, and macrophages with antibacterial anti-inflammatory properties. In the context of Gram-negative infection, BPI kills bacteria, neutralizes the endotoxic activity of lipopolysaccharides (LPSs), and, thus, avoids immune hyperactivation. Interestingly, BPI increases in patients with Gram-positive meningitis, interacts with lipopeptides and lipoteichoic acids of Gram-positive bacteria, and significantly enhances the immune response in peripheral blood mononuc

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18

Arisoy, Mustafa, Ozlem Temiz-Arpaci, Fatma Kaynak-Onurdag, and Selda Ozgen. "Novel Benzoxazoles: Synthesis and Antibacterial, Antifungal, and Antitubercular Activity against Antibiotic-Resistant and -Sensitive Microbes." Zeitschrift für Naturforschung C 68, no. 11-12 (2013): 453–60. http://dx.doi.org/10.1515/znc-2013-11-1204.

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A new series of 5-(p-substituted benzamido/phenylacetamido)-2-(p-tert-butylphenyl)benzoxazole derivatives were synthesized and evaluated for their antibacterial, antifungal, and antimycobacterial activities against antibiotic-resistant and -sensitive Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Mycobacterium tuberculosis as well as against Candida albicans and Candida krusei. The compounds possessed broad-spectrum activity against all of the tested Gram-positive and Gram-negative bacteria and yeasts, their minimum inhibitory concentrations (MICs) r

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Ambrożkiewicz, Weronika, Marta Kučerová-Chlupáčová, Ondřej Janďourek, et al. "5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation." Molecules 25, no. 7 (2020): 1561. http://dx.doi.org/10.3390/molecules25071561.

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According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis against currently used antituberculars is an imperative to develop new compounds with potential antimycobacterial activity. As a part of our continuous research on structural derivatives of the first-line antitubercular pyrazinamide, we have designed, prepared, and assessed the in vitro whole cell growth inhibition activity of forty-two novel 5-alky

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20

Shivam, Joshi* Neha Kawathekar. "Synthesis And Biological Evaluation of Alkylated Indole Chalcone Derivatives as Antitubercular and Antimicrobial Agents." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2441–51. https://doi.org/10.5281/zenodo.14516472.

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Infection with the bacteria <em>Mycobacterium tuberculosis</em> causes the disease tuberculosis. In Present research work we synthesized some N-alkylated indole chalcone derivatives and determined their biological activity against the H37Rv strain of <em>Mycobacterium tuberculosis</em>. Inside this library of compounds, (E)-1-(4-bromo-2-hydroxyphenyl)-3-(1-butyl-1H-indol-3-yl)prop-2-en-1-one (S1R8) and (E)-1-(4-bromo-2-hydroxyphenyl)-3-(1-pentyl-1H-indol-3-yl)prop-2-en-1-one (S1R16) displayed anti-tubercular activity with 04 µg/mL and 08 µg/mL MIC values, respectively. The in vitro

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Zhang, Ying, Angelo Scorpio, Hiroshi Nikaido, and Zhonghe Sun. "Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide." Journal of Bacteriology 181, no. 7 (1999): 2044–49. http://dx.doi.org/10.1128/jb.181.7.2044-2049.1999.

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ABSTRACT Pyrazinamide (PZA) is an important antituberculosis drug. Unlike most antibacterial agents, PZA, despite its remarkable in vivo activity, has no activity against Mycobacterium tuberculosis in vitro except at an acidic pH. M. tuberculosis is uniquely susceptible to PZA, but other mycobacteria as well as nonmycobacteria are intrinsically resistant. The role of acidic pH in PZA action and the basis for the unique PZA susceptibility of M. tuberculosisare unknown. We found that in M. tuberculosis, acidic pH enhanced the intracellular accumulation of pyrazinoic acid (POA), the active deriva

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Navarro-García, Víctor Manuel, Julieta Luna-Herrera, Ma Gabriela Rojas-Bribiesca, Patricia Álvarez-Fitz, and María Yolanda Ríos. "Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis." Molecules 16, no. 9 (2011): 7357–64. http://dx.doi.org/10.3390/molecules16097357.

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Wardani, Giftania, Mahmiah M, and Sri Agus Sudjarwo. "In vitro Antibacterial Activity of Chitosan Nanoparticles against Mycobacterium tuberculosis." Pharmacognosy Journal 10, no. 1 (2017): 162–66. http://dx.doi.org/10.5530/pj.2018.1.27.

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Assis, Leticia Ribeiro de, Reinaldo dos Santos Theodoro, Maria Beatriz Silva Costa, et al. "Antibacterial Activity of Isobavachalcone (IBC) Is Associated with Membrane Disruption." Membranes 12, no. 3 (2022): 269. http://dx.doi.org/10.3390/membranes12030269.

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Isobavachalcone (IBC) is a natural prenylated chalcone with a broad spectrum of pharmacological properties. In this work, we newly synthesized and investigated the antibacterial activity of IBC against Gram-positive, Gram-negative and mycobacterial species. IBC was active against Gram-positive bacteria, mainly against Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA), with minimum inhibitory concentration (MIC) values of 1.56 and 3.12 µg/mL, respectively. On the other hand, IBC was not able to act against Gram-negative species (MIC >

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Pucci, Michael J., Maria Ackerman, Jane A. Thanassi, Carolyn M. Shoen, and Michael H. Cynamon. "In Vitro Antituberculosis Activities of ACH-702, a Novel Isothiazoloquinolone, against Quinolone-Susceptible and Quinolone-Resistant Isolates." Antimicrobial Agents and Chemotherapy 54, no. 8 (2010): 3478–80. http://dx.doi.org/10.1128/aac.00287-10.

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ABSTRACT ACH-702 is a new isothiazoloquinolone with potent in vitro and in vivo activities against important bacterial pathogens, including Staphylococcus aureus. In this study, ACH-702 was found to have promising in vitro antibacterial activity against Mycobacterium tuberculosis, with MICs of ≤1 μg/ml, comparable to that of the fluoroquinolone moxifloxacin for quinolone-susceptible isolates but superior to that for quinolone-resistant isolates. Biochemical assays involving M. tuberculosis gyrase enzymes indicated that ACH-702 had significantly improved inhibitory activity compared with fluoro

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Brucoli, Federico. "DNA-Minor Groove Binding Agents as Anti-Tubercular Probes. Old Tools for a New Challenge?" Anti-Infective Agents 16, no. 2 (2018): 71–79. http://dx.doi.org/10.2174/2211352516666180612080830.

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Tuberculosis, an ancient infectious disease caused by Mycobacterium tuberculosis, ranks as one of the top ten killers worldwide. The limited number of validated targets and scarce therapeutic options demand that renewed efforts should be made to identify tuberculosis drugs with novel mechanisms of action. To this end, mycobacterial DNA might represent a potential target for the development of effective anti-tubercular compounds. In particular, the minor groove of DNA offers an important recognition site for small-molecules that can be programmed to bind to this region in a sequence-selective m

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Monsef Esfahani, Hamidreza, Mahdi Moridi Farimani, Samad Nejad Ebrahimi, et al. "Antibacterial Components of Levisticum officinale Koch against Multidrug-resistant Mycobacterium tuberculosis." Pharmaceutical Sciences 26, no. 4 (2020): 441–47. http://dx.doi.org/10.34172/ps.2020.38.

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Background: A bioassay-guided fractionation technique was used to evaluate the active constituents of the perennial plant L. officinale W.D.J. Koch (Apiaceae) against multidrug resistant (MDR) Mycobacterium tuberculosis. Methods: Column chromatography was used to isolation of compounds from L. officinale and spectroscopic methods including 1D and 2D NMR (Nuclear magnetic resonance) and HRMS (high resolution mass spectrometry) were used to identification of the isolated compounds. Also, to evaluate antibacterial activity, minimum inhibitory concentration (MIC) was carried out by broth micro-dil

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Catalão, Maria, and Madalena Pimentel. "Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope." Viruses 10, no. 8 (2018): 428. http://dx.doi.org/10.3390/v10080428.

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Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus being potential candidates as antibacterial agents. These comprise lipolytic enzymes that target the mycolic acid-containing outer membrane and peptidoglycan hydrolases responsive to the atypical mycobacterial peptidoglycan layer. In the recent years, a remarkable progress has been made, particularly on the comprehension of the mechanisms of bac

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Litvinov, I. V., S. G. Safonova, I. V. Peretokina, and M. V. Litvinov. "Activity of bedaquiline against mycobacteria (review)." Tuberculosis and socially significant diseases 12, no. 3 (2024): 59–69. https://doi.org/10.54921/2413-0346-2024-12-3-59-69.

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Resistance of M. tuberculosis to anti-tuberculosis drugs (ATDs) and then to antibacterial drugs initially developed for other purposes, but effective against M. tuberculosis is an extremely serious problem. Treatment of drug-resistant tuberculosis is difficult, it is significantly more expensive, and its effectiveness is lower than in the treatment of drug-sensitive tuberculosis. With the advent of new anti-TB drugs such as bedaquiline and delamanid, the efficacy of etiotropic chemotherapy for MDR- and XDR-TB has increased significantly.The review shows that bedaquiline has high activity in vi

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Rajendran, Sudha, Brindha Devi P, Charles C. Kanakam, and Nithya G. "DOCKING STUDIES FOR VARIOUS ANTIBACTERIAL BENZILATE DERIVATIVES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 268. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16713.

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Objectives: In this study, we have focused on discovering the leads for the enzyme targets of infectious disease tuberculosis. We employed computeraided drug design docking tool,to discover new leads for Mycobacterium tuberculosis (MTB).Methods: Five compounds were synthesized and they are made to dock into the active site of the enzyme; retrieved from protein data bank.Results: The docking studies and structure–activity relationship reveals that the compound 2’-chloro-4-methoxy-3nitro benzilic acid after threedifferent docking strategies reveals that the score was found to be higher compared

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N. Djide, Nana Juniarti, M. Natsir Djide, Muhammad Nur Amir, and Sartini Sartini. "Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) 5, no. 2 (2019): 117. http://dx.doi.org/10.22487/j24428744.0.v0.i0.12946.

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First-line drugs (Isoniazid and Rifampicin) for the treatment of tuberculosis are known to have experienced resistance to Mycobacterium tuberculosis. The aim of this study was to determine the minimum inhibitory concentration (MIC) of maltodextrin encapsulated rosella calyx extract and its ability to provide a synergistic effect with Isoniazid (INH) and Rifampicin (RIF) on M. tuberculosis R37rv. Rosella calyxs were macerated using 50% ethanol and encapsulated using maltodextrin. Antibacterial activity was carried out by determining MIC value using Microscopic Observation and Direct Susceptibil

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N. Djide, Nana Juniarti, M. Natsir Djide, Muhammad Nur Amir, and Sartini Sartini. "Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 5, no. 2 (2019): 117–23. http://dx.doi.org/10.22487/j24428744.2019.v5.i2.12946.

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First-line drugs (Isoniazid and Rifampicin) for the treatment of tuberculosis are known to have experienced resistance to Mycobacterium tuberculosis. The aim of this study was to determine the minimum inhibitory concentration (MIC) of maltodextrin encapsulated rosella calyx extract and its ability to provide a synergistic effect with Isoniazid (INH) and Rifampicin (RIF) on M. tuberculosis R37rv. Rosella calyxs were macerated using 50% ethanol and encapsulated using maltodextrin. Antibacterial activity was carried out by determining MIC value using Microscopic Observation and Direct Susceptibil

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Ito, Hazuki, Kohei Monobe, Saya Okubo, and Shunsuke Aoki. "Identification of Novel Antimicrobial Compounds Targeting Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase Using Dual Hierarchical In Silico Structure-Based Drug Screening." Molecules 29, no. 6 (2024): 1303. http://dx.doi.org/10.3390/molecules29061303.

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The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis (M. tuberculosis) has become a major medical problem. S-adenosyl-L-homocysteine hydrolase (MtSAHH) was selected as the target protein for the identification of novel anti-TB drugs. Dual hierarchical in silico Structure-Based Drug Screening was performed using a 3D compound structure library (with over 150 thousand synthetic chemicals) to identify compounds that bind to MtSAHH’s active site. In vitro experiments were conducted to verify whether the nine compounds selected as new drug candidates exhibi

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Akula, Ravi K., Shanthan R. Pamulaparthy, Pranay K. Koochana, and Dharmarajan Sriram. "Synthesis and In vitro Antibacterial, Antitubercular Studies of Novel Fluoroquinolones Analogs Containing 4-substituted Sec Amine." Current Bioactive Compounds 15, no. 6 (2020): 656–64. http://dx.doi.org/10.2174/1573407214666180529124816.

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Background: Tuberculosis is a contagious, air borne disease and second leading cause of death among infectious diseases worldwide. Fluoroquinolones are well-known antibacterial agents and they were recommended as second-line of antitubercular drugs. Method: A series of novel fluoroquinolone analogs 6-24 was effectively synthesized. An attempt was made by tagging the substituted pyrazole on to fluoroquinolones for the first time at C-7 position. The newly synthesized compounds were characterized by FTIR, 1HNMR, ESI-MS, HR-MS and elemental analysis. The in vitro antibacterial activity of all the

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Khandazhinskaya, Anastasia, Elena Matyugina, Pavel Solyev, et al. "Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents." Molecules 24, no. 19 (2019): 3433. http://dx.doi.org/10.3390/molecules24193433.

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Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

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Nunez, Marvin J., Alma D. Paz-Gonzalez, Lenci K. Vazquez-Jimenez, et al. "In vitroantiparasitic and antibacterial evaluation of organic extracts of Salvadoran flora." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 1 (2023): 19–36. http://dx.doi.org/10.37360/blacpma.23.22.1.2.

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Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and causes several side effects in patients. Therefore, the searchfor new compounds with biological activity is very important to develop new drugs safely and more efficiently. In this study, different organic extracts obtained from thirty-seven species of the Salvadoran flora were evaluated in several in vitromodels to

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Gundersen, Lise-Lotte, Colin Charnock, Ayele Hailu Negussie, Frode Rise, and Solomon Teklu. "Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis." European Journal of Pharmaceutical Sciences 30, no. 1 (2007): 26–35. http://dx.doi.org/10.1016/j.ejps.2006.09.006.

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Kang, Sung-Min, Heejo Moon, Sang-Woo Han, et al. "Toxin-Activating Stapled Peptides Discovered by Structural Analysis Were Identified as New Therapeutic Candidates That Trigger Antibacterial Activity against Mycobacterium tuberculosis in the Mycobacterium smegmatis Model." Microorganisms 9, no. 3 (2021): 568. http://dx.doi.org/10.3390/microorganisms9030568.

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The structure-function relationships of toxin-antitoxin (TA) systems from Mycobacterium tuberculosis have prompted the development of novel and effective antimicrobial agents that selectively target this organism. The artificial activation of toxins by peptide inhibitors can lead to the growth arrest and eventual death of bacterial cells. Optimizing candidate peptides by hydrocarbon α-helix stapling based on structural information from the VapBC TA system and in vitro systematic validation led to V26-SP-8, a VapC26 activator of M. tuberculosis. This compound exhibited highly enhanced activity

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Jasim, Thamer Mutlag, Baydaa Hameed Abdullah, Suhad Faisel Al Mugdadi, and Mayssam Camel. "Antimicrobial activity of Origanum magorana against bacteria isolated from the patient with pneumonia." Al Mustansiriyah Journal of Pharmaceutical Sciences 7, no. 1 (2010): 130–36. http://dx.doi.org/10.32947/ajps.v7i1.325.

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A total of 150 sputum sample from the patient attendants to medical city and Ibn Al-Balady hospital during the period from February 2009 to May 2009 with signs and symptoms of pneumonia only 57 sputum samples 53. 5 gave bacterial growth positive, the result indicated the most frequent microorganismswere 18 isolate (22.5%) Klebsiella pneumonia, 16 isolate (20%) Pseudomonas aeruginosa, 5 isolate (6.25%) Candida albicans, 5 isolate (6.25%) Acinetobacter spp, 5 isolate (6.25%) Eschereshia coli, 4 isolate (5%) Mycobacterium tuberculosis, 3 isolates (3.75%) proteus spp, 1 isolate (1.25%) Enterobacte

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Lee, So Young, Gauri S. Shetye, So-Ri Son, et al. "Anti-Microbial Activity of Aliphatic Alcohols from Chinese Black Cardamom (Amomum tsao-ko) against Mycobacterium tuberculosis H37Rv." Plants 12, no. 1 (2022): 34. http://dx.doi.org/10.3390/plants12010034.

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The fruits of Amomun tsao-ko (Chinese black cardamom; Zingiberaceae) contain an abundance of essential oils, which have previously demonstrated significant antimicrobial activity. In our preliminary search for natural anti-tuberculosis agents, an acetone extract of A. tsao-ko (AAE) exhibited strong antibacterial activity against Mycobacterium tuberculosis H37Rv. Therefore, the aim of this study was to find the principal compounds in an AAE against M. tuberculosis. Nine aliphatic compounds (1−9) including a new compound (1, tsaokol B) and a new natural unsaturated aliphatic diester (6), togethe

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G, Nithya, Sudha R, Brindha Devi P, and Charles C. Kanakam. "IN SILICO STUDIES FOR VARIOUS ANTIBACTERIAL BENZIL AND ITS SUBSTITUTED ANALOGS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (2017): 186. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.19905.

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Objective: The antibacterials have moved on to low levels by more challenges toward antibacterial discovery of drug over an earlier period of 30 years. The resistance pathogens such as Staphylococcus aureus, Mycobacterium tuberculosis (MTB), and Streptococcus pneumoniae are nowadays facing difficulty in effective treatment. This leads to the necessary for the new discovery of drugs for antibacterial activity. The foremost disease in the world among all the infectious disease is found to tuberculosis (TB) which causes high proportions of mortality. Hence, we have decided on identifying the lead

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Ufimtseva, Elena G., Natalya I. Eremeeva, Tatiana V. Umpeleva, Diana V. Vakhrusheva, and Sergey N. Skornyakov. "Mycobacterium tuberculosis Load in Host Cells and the Antibacterial Activity of Alveolar Macrophages Are Linked and Differentially Regulated in Various Lung Lesions of Patients with Pulmonary Tuberculosis." International Journal of Molecular Sciences 22, no. 7 (2021): 3452. http://dx.doi.org/10.3390/ijms22073452.

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Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (Mtb) infection with the formation of a broad range of abnormal lung lesions within a single patient. Although host–pathogen interactions determine disease outcome, they are poorly understood within individual lesions at different stages of maturation. We compared Mtb load in a tuberculoma wall and the lung tissue distant from tuberculomas in TB patients. These data were combined with an analysis of activation and bactericidal statuses of alveolar macrophages and other cell subtypes examined both in ex vivo culture and on the

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Ramón-García, Santiago, Ralf Mikut, Carol Ng, et al. "Targeting Mycobacterium tuberculosis and Other Microbial Pathogens Using Improved Synthetic Antibacterial Peptides." Antimicrobial Agents and Chemotherapy 57, no. 5 (2013): 2295–303. http://dx.doi.org/10.1128/aac.00175-13.

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ABSTRACTThe lack of effective therapies for treating tuberculosis (TB) is a global health problem. WhileMycobacterium tuberculosisis notoriously resistant to most available antibiotics, we identified synthetic short cationic antimicrobial peptides that were active at low micromolar concentrations (less than 10 μM). These small peptides (averaging 10 amino acids) had remarkably broad spectra of antimicrobial activities against both bacterial and fungal pathogens and an indication of low cytotoxicity. In addition, their antimicrobial activities displayed various degrees of species specificity th

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Teo, Jeanette W. P., Pamela Thayalan, David Beer, et al. "Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents." Antimicrobial Agents and Chemotherapy 50, no. 11 (2006): 3665–73. http://dx.doi.org/10.1128/aac.00555-06.

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ABSTRACT Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium tuberculosis, was demonstrated through genetic knockout experiments with Mycobacterium bovis BCG. PDF from M. tuberculosis strain H37Rv was cloned, expressed, and purified as an N-terminal histidine-tagged recombinant protein in Escherichia coli. A novel class of PDF inhibitors (PDF-I), th

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Wang, Ting, Huiyue Zhang, Rui Feng, Jieru Ren, Xinping Xu, and Shujuan Sun. "The in vitro antimicrobial activity of linezolid against unconventional pathogens." PeerJ 13 (February 12, 2025): e18825. https://doi.org/10.7717/peerj.18825.

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Linezolid is an oxazolidinone antibiotic that is mainly permitted to treat Gram-positive bacterial infections. Recent studies have shown that linezolid also has antibacterial effects on several other bacteria outside the package insert, including Mycobacterium tuberculosis, non-tuberculous mycobacteria (NTM), Nocardia, Corynebacterium, and anaerobes, etc. Interestingly, linezolid also has an in vitro inhibitory effect on fungi. This review focuses on the in vitro antibacterial activity of linezolid against microorganisms outside its antibacterial spectrum. We mainly listed the number of the te

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Rakhmawatie, Maya Dian, Aida Zakiyatul Fikriyah, Ika Dyah Kurniati, Nanik Nanik Marfu'ati, and Stalis Norma Ethica. "Secondary Metabolites Production of Bacillus spp. Isolated from Sea Cucumbers (Holothuria scabra) and their Activity against Mycobacterium smegmatis." Journal of Pharmaceutical Sciences and Community 20, no. 2 (2023): 169–78. http://dx.doi.org/10.24071/jpsc.004843.

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New anti-tuberculosis agents are very important due to Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis problems. Mycobacterium smegmatis can be used to replace Mycobacterium tuberculosis as bacteria test to increase the velocity of anti-tuberculosis screening. To answer the need for new drugs, exploration of secondary metabolites from Bacillus spp. can be conducted. Bacillus spp. are known to produce antimicrobials, including discovery of iturins, fengycins, and pumilacidins. This study explored the Bacillus spp. isolated from fermented intestines of Holothuria scabra. The prod

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Liao, Guojian, Zhengyuan Ye, Yunlu Liu, Bin Fu, and Chen Fu. "Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium." PeerJ 5 (April 27, 2017): e3252. http://dx.doi.org/10.7717/peerj.3252.

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Tuberculosis is one of the world’s deadliest infectious disease with 1.5 millions deaths annually. It is imperative to discover novel compounds with potent activity against M. tuberculosis. In this study, susceptibilities of M. smegmatis to the octahedral ruthenium(II) polypyridyl complexes, 1 {[(bpy)3Ru] (PF6)2 (bpy = 2,2′-bipyridine)}, 2 {[(phen)2Ru(dppz)](PF6)2 (phen = 1,10-phenanthroline, dppz = dipyridophenazine)} and 3 {[(phen)3Ru](PF6)2} were measured by broth microdilution and reported as the MIC values. Toxicities of complex 3 to LO2 and hepG2 cell lines were also measured. Complex 2

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Md, Akram* Abdul Sayeed Syed Shah Abdus Salaam. "STUDIES ON THE DESIGN, SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME NEW QUINAZOLINONE DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1915–25. https://doi.org/10.5281/zenodo.1211686.

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Quinazolinone derivatives are the versatile nitrogen containing heterocyclic compounds displaying a wide variety of biological and pharmacological activities like antibacterial, anthelmintic,neuroleptic,antitubercular,platelet,antiaggregating,antifungal,anticancer,anti-inflammatory,antiviral,CNSdepressant activity,antiparkinson,bronchodilator etc. Recently several scientists have elucidated that Quinazolinone system possesses variable sites like position 2 and 3 which can be suitably modified to yield new potent chemotherapeutic and pharmacotherapeutic agents. Further, Schiff bases are use as

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Kazakova, Oxana, Roxana Racoviceanu, Anastasiya Petrova, et al. "New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design." International Journal of Molecular Sciences 22, no. 22 (2021): 12542. http://dx.doi.org/10.3390/ijms222212542.

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Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its related derivatives and their antitubercular activity against Mycobacterium tuberculosis, mono-resistant MTB strains, and nontuberculous strains Mycobacterium abscessus and Mycobacterium avium were investigated in the framework of AToMIc (Anti-mycobacterial Target or Mechanism Identification Contract) realized by the Division of Microbiology and Infectious Diseases, NIAID, National Institute of Health. Of all the tested triterpenoids, 17 compounds showed antitubercular activity and 6 compounds were highly act

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Hakim, Farhana, and S. Roshan Salfidoer. "Antibacterial and Antitubercular Activity of Novel Benzothiazole- Aryl Amine Derivatives Tethered through Acetamide Functionality." Asian Journal of Chemistry 33, no. 8 (2021): 1757–63. http://dx.doi.org/10.14233/ajchem.2021.23226.

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A novel series of substituted benzothiazole-N-phenyl acetamides were synthesized through a feasible scheme and characterized by IR, 1H NMR and mass spectral methods. All the synthesized compounds were screened for antibacterial activity against two, Gram-positive strains: Staphylococcus aureus, Bacillus subtilis; four, Gram-negative strains: Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella pneumonia; and antitubercular activity against mycobacterial strain: Mycobacterium tuberculosis. Among the 15 compounds (6a-o) tested, three compounds 6e, 6l and 6m have demonstrated

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