Academic literature on the topic 'Tuberculosis Swaziland'

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Journal articles on the topic "Tuberculosis Swaziland"

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Sanchez-Padilla, Elisabeth, Themba Dlamini, Alexandra Ascorra, Sabine Rüsch-Gerdes, Zerihun Demissie Tefera, Philippe Calain, Roberto de la Tour, Frauke Jochims, Elvira Richter, and Maryline Bonnet. "High Prevalence of Multidrug-Resistant Tuberculosis, Swaziland, 2009–2010." Emerging Infectious Diseases 18, no. 1 (January 2012): 29–37. http://dx.doi.org/10.3201/eid1801.110850.

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Mchunu, G., J. van Griensven, S. G. Hinderaker, W. Kizito, W. Sikhondze, M. Manzi, T. Dlamini, and A. D. Harries. "High mortality in tuberculosis patients despite HIV interventions in Swaziland." Public Health Action 6, no. 2 (June 21, 2016): 105–10. http://dx.doi.org/10.5588/pha.15.0081.

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DiNardo, Andrew R., Anna M. Mandalakas, Gugu Maphalala, Godwin Mtetwa, Temhlanga Mndzebele, Piluca Ustero, Makhosazana Hlatshwayo, Emily M. Mace, Jordan S. Orange, and George Makedonas. "HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response." Mediators of Inflammation 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/1478340.

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Introduction. Our objective is to understand how HIV infection increases the risk of progression from latent tuberculosis (TB) to active disease. We understand now that immunity is a balance of competing immune responses by multiple cell types. Since T-lymphocyte production of interferon-gamma (IFN-γ) in response toMycobacterium tuberculosis (Mtb) antigens fails to differentiate disease from latent infection, we applied a comprehensive profiling methodology to define immune biomarkers that reliably predict a patient’s TB risk.Methods. We established a cohort of HIV-infected adults with TB disease from Swaziland. Multiparametric flow cytometry was used to quantify the mycobacterial-specific anti-inflammatory (IL-4 and IL-10) and proinflammatory (IFN-γ) immune response.Results. From 12 HIV-infected Swaziland patients with TB disease, the CD4+, CD8+, Double Negative, and CD56+CD3−lymphocytes increase their IL-4 : IFN-γratio as HIV disease worsens (Spearmanrof −0.59; −0.59; −0.60; and −0.59, resp.;p<0.05). Similarly, HIV severity is associated with an increased IL-10 : IFN-γratio (Spearmanrof −0.76;p=0.01).Conclusion. As HIV disease progresses, both the adaptive and innate branches skew away from an inflammatory and towards anti-inflammatory phenotype.
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Sanchez-Padilla, Elisabeth, Matthias Merker, Patrick Beckert, Frauke Jochims, Themba Dlamini, Patricia Kahn, Maryline Bonnet, and Stefan Niemann. "Detection of Drug-Resistant Tuberculosis by Xpert MTB/RIF in Swaziland." New England Journal of Medicine 372, no. 12 (March 19, 2015): 1181–82. http://dx.doi.org/10.1056/nejmc1413930.

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Calnan, Marianne, Samson Haumba, Makhosazana Matsebula, Ntombifuthi Shongwe, Munyaradzi Pasipamire, Natalie K. Levy, Munamato Mirira, Peter Preko, Alisha Smith-Arthur, and Varduhi Ghazaryan. "Delivery of isoniazid preventive therapy to reduce occupational TB among healthcare workers in Swaziland." Southern African Journal of Infectious Diseases 32, no. 1 (March 31, 2017): 1–4. http://dx.doi.org/10.4102/sajid.v32i1.68.

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Healthcare workers (HCWs) in Swaziland are at increased risk of acquiring tuberculosis (TB), but existing infection control and occupational health policies often fall short of mitigating the risk of acquiring TB in the workplace. Health service failure to systematically offer isoniazid preventive therapy (IPT) to HCWs, which is endorsed by the World Health Organisation (WHO), contributes significantly to the TB incidence among HCWs in high HIV prevalence settings. This paper describes a pilot introduction of IPT to HCWs, and expounds possible determinants for adherence and non-acceptance to IPT. Acceptance to the widespread use of IPT among HCWs can be improved through education on risk and counselling.
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Pushpananthan, S., J. D. Walley, and J. Wright. "Tuberculosis in Swaziland: A Health Needs Assessment in Preparation for a Community-Based Programme." Tropical Doctor 30, no. 4 (October 2000): 216–20. http://dx.doi.org/10.1177/004947550003000412.

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Haumba, S., T. Dlamini, M. Calnan, V. Ghazaryan, A. E. Smith-Arthur, P. Preko, and P. Ehrenkranz. "Declining tuberculosis notification trend associated with strengthened TB and expanded HIV care in Swaziland." Public Health Action 5, no. 2 (June 21, 2015): 103–5. http://dx.doi.org/10.5588/pha.15.0008.

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Nkambule, Bongi Siyabonga, Jane Lee-Hsieh, Chieh-Yu Liu, and Su-Fen Cheng. "The relationship between patients’ perception of nurse caring behaviors and tuberculosis stigma among patients with drug-resistant tuberculosis in Swaziland." International Journal of Africa Nursing Sciences 10 (2019): 14–18. http://dx.doi.org/10.1016/j.ijans.2018.11.004.

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Escott, Sarah, and John Walley. "Listening to those on the frontline: Lessons for community-based tuberculosis programmes from a qualitative study in Swaziland." Social Science & Medicine 61, no. 8 (October 2005): 1701–10. http://dx.doi.org/10.1016/j.socscimed.2005.03.040.

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Ustero, Piluca Alonzo, Alexander W. Kay, Katherine Ngo, Rachel Golin, Bhekisisa Tsabedze, Bulisile Mzileni, Jessica Glickman, Mildred Wisile Xaba, Gcinile Mavimbela, and Anna Maria Mandalakas. "School and household tuberculosis contact investigations in Swaziland: Active TB case finding in a high HIV/TB burden setting." PLOS ONE 12, no. 6 (June 5, 2017): e0178873. http://dx.doi.org/10.1371/journal.pone.0178873.

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Dissertations / Theses on the topic "Tuberculosis Swaziland"

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Lemmer, Hermann Richard. "The tuberculosis control programme in the industry in Swaziland : a critical evaluation." Diss., Access to E-Thesis, 2002. http://upetd.up.ac.za/thesis/available/etd-10032005-092729/.

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Dube, Muzi Mzwandile. "Molecular characterization of bovine tuberculosis strains in Swaziland." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/31139.

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The aim of the study was to gain knowledge on molecular techniques (spoligotyping and VNTR typing) in analysis of the Mycobacterium tuberculosis complex and characterize M. bovis isolates available in Swaziland.
Dissertation (MSc)--University of Pretoria, 2012.
Veterinary Tropical Diseases
MSc
Unrestricted
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Phiri, Elias. "Reasons for refusing antiretroviral therapy before completion of tuberculosis treatment at Pigg's Peak Hospital, Swaziland." Thesis, University of Limpopo (Medunsa Campus), 2013. http://hdl.handle.net/10386/1069.

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Thesis (MPH)--University of Limpopo, 2013.
Statistics from Pigg’s Peak Hospital, in Swaziland, continue to show an improvement in the uptake of HIV testing among TB patients, as well as a very high rate of HIV co-infection among the TB patients. The unit’s reports also show a low uptake of antiretroviral therapy among the HIV co-infected TB patients, and high death rates. Most of these deaths occur among HIV co-infected TB patients who have not yet initiated ART despite being on TB treatment. Anecdotal evidence suggests that there is reluctance and refusal by a considerable proportion of TB/HIV co-infected patients to take TB treatment and ART concurrently, and that they prefer to commence ART after completing TB treatment. No study has ever been conducted in Swaziland to determine the reasons for refusal of ART initiation prior to the completion of TB treatment among HIV co-infected TB patients. Aim The aim of this study was to explore the reasons for refusing antiretroviral therapy among HIV co-infected tuberculosis patients, prior to the completion of tuberculosis treatment, at Pigg’s Peak Hospital, in Swaziland. Methods A qualitative descriptive study was conducted in order to generate information on the subjects’ experiences and views on the concurrent taking of tuberculosis and antiretroviral medicines. A sample of nineteen HIV co-infected TB patients was purposefully selected to answer the research question. Results The most common reasons given by the respondents for refusing ART initiation during TB therapy were their un-readiness for ART, especially because ART must be taken for life, the perception that one was still in good health, the fear of adverse outcomes being precipitated by combining ART with TB medicines, a preference of traditional medicines, and health systems-related problems. Other reasons were: a lack of food, substance abuse, a fear of the increased pill burden, a denial of the HIV-positive status, and problems related to treatment supporters. Conclusion In TB/HIV co-infection care settings, comprehensive Pre-ART counseling must be integrated with interventions that address the specific barriers to ART initiation faced by clients; to improve the acceptability of ART initiation during TB therapy to these HIV/TB co-infected patients.
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Musarapasi, Normusa. "Review of outcomes for isoniazid preventive therapy among HIV infected clients at a clinic in Swaziland." University of the Western Cape, 2019. http://hdl.handle.net/11394/6887.

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Magister Public Health - MPH
Background: TB is one of the most common opportunistic infections in the HIV infected population. In 2014, of the 9.6 million people estimated to have TB globally, 1.2 million were also infected with HIV. In the same year WHO reported 400 000 TB deaths in HIV infected people worldwide. TB Prevention strategies include ensuring HIV infected people take ART, TB infection control, treatment of TB cases and pharmacological prevention of primary TB infection or progression of latent TB into active TB. Isoniazid preventive therapy for a minimum of six months has been recommended to reduce the risk of TB in people living with HIV. Aim: The study’s aim was to determine the programmatic outcomes of isoniazid preventive therapy (IPT) and factors associated with treatment completion among people living with HIV aged 15 years and above at the AIDS Healthcare Foundation LaMvelase clinic in Manzini Swaziland, who were enrolled for IPT during the period March to December 2014. Methodology: This was a quantitative retrospective analytical cohort study that reviewed 3642 patient care records. IBM SPSS 20 was used for descriptive and statistical analysis of the data. Descriptive statistics were calculated and reported as frequencies and percentages. Bivariate statistics were carried out to test independent associations between socio-demographic and clinical characteristics, and IPT completion. Further multiple logistic regression analysis was done to determine the nature of association between the dependent and independent variables which had p < 0.1.
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Dlamini, Mbali Sichasiso, and 施蓓俐. "Factors Associated with Tuberculosis Treatment Outcomes in Manzini, Swaziland." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/49872571489257868961.

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碩士
國立陽明大學
國際衛生碩士學位學程
102
Though Directly Observed Treatment Short Course protocol has been implemented in a bid to control tuberculosis in Swaziland since 2006, yet treatment outcomes have not been studied in this high TB/HIV co-infection country. This study seeks to examine tuberculosis treatment outcomes and investigate associated factors among tuberculosis patients in Manzini, Swaziland. A retrospective cohort study was carried among tuberculosis cases receiving treatments at the Manzini TB center from January to December 2012. Treatment outcomes were followed from July to September 2013. A total of 556 patients (55.2 % male, 44.8% female) with a mean age of 35.8 years were treated; 324 (58.3%) were smear-positive pulmonary TB cases and 232 (41.7%) were smear-negative pulmonary TB cases. 412 (76%) of the patients were HIV positive and most (85.6%) were new cases. 500 (76%) patients successfully completed treatment. Of those who completed treatment, 138 (32.3%) patients were cured as confirmed by smear negative results and 288 (67.7%) were neither cured or failures. Other outcomes of TB treatment were death 57 (10.3%), failure 32 (5.8%) and 41 (7.4%) defaulted TB treatment. Multinomial logistic regression results showed that male gender, smear-negative pulmonary TB, re-treatment case and being HIV positive were more likely to be associated with death, failure, default or completed (not cured group). The tuberculosis treatment outcome as suboptimal and targeted measures should be considered to reduce the rate of poor treatment outcome among high risk groups. Special attention should also be given to the proportion of patients that completes treatment but are not cured from TB. Although the tuberculosis criteria set by the WHO appears to be clear and comprehensive, they have limitations and require refinement in high burden and low income countries.
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Dlamini, Lindiwe Felicity, and 費德琳. "Predictors of Treatment Outcomes Among Drug Resistant Tuberculosis Patients in Swaziland." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/763ryt.

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碩士
國立陽明大學
國際衛生碩士學位學程
106
Background: Drug resistant tuberculosis (DR-TB) is a critical threat to public health in Swaziland. Despite efforts that the Government of Swaziland has put towards the management of this disease, treatment outcomes for DR-TB patients remain poor. The study aimed to investigate predicting factors of treatment outcomes among DR-TB patients in Swaziland. Methods: A retrospective cohort design was adopted where secondary review of medical records of all adult patients who initiated DR-TB treatment in Swaziland between January 2013 and December 2014 was done. A total of 800 DR-TB patients’ records were included in the analysis. X2 test was used to determine association among variables. Multinomial logistic regression analysis was used to identify predictors of DR-TB treatment outcomes. Data with P-value <0.05 or equivalent was considered significant. Results: Of the 800 patients, 419 (52.4%) were cured, 157 (19.6%) completed treatment, 149 (18.6%) died, 52 (6.5%) were lost to follow up (LTFU) and 23 (2.9%) failed treatment. Predictors of mortality after adjustment were: age 40 years and older (OR 2.105, P=0.001); age 15-24 years (OR 1.968, P=0.050); rural residence (OR 1.720, P=0.035); Rifampicin mono resistance (OR 3.822, P=0.002); Rifampicin and Isoniazid resistance only (OR 3.088, P=0.035); non-DOT (OR 2.352, P=0.053); non-provision of food and transport support (OR 2.041, P=0.022). Predictor of LTFU was non-provision of food and transport support during treatment (OR 11.372, P=<0.001). Predictor for treatment success was being located in the Shiselweni region (OR 4.85, P=0.009). Conclusion: This study revealed high burden of DR-TB accompanied with high mortality which was mostly related to the patient’s demographic, clinical and social support characteristics. Intensification of interventions targeted at early diagnosis and treatment as well as addressing social risks factors that hinder adherence to treatment is necessary to improve DR-TB treatment outcomes in Swaziland.
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Shongwe, Ntombifuthi. "Risk factors influencing the epidemiology of drug resistant tuberculosis patients enrolled for treatment at the National Tuberculosis Referral Hospital, Swaziland." Diss., 2015. http://hdl.handle.net/10500/20995.

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The purpose of this study was to establish empirical evidence on risk factors influencing drug-resistant tuberculosis (DR-TB) in Swaziland. Globally factors have been identified and specific programmatic interventions were implemented to counter the emergence of DR-TB, but the case still remains with Swaziland. The research question was “What are the risk factors influencing the epidemiology of DR-TB patients enrolled for treatment at the National Tuberculosis Referral Hospital? The research objectives were to investigate factors that influence the emergence of DR-TB in Swaziland, to establish the relationship between DR-TB and HIV and to develop a poster that will exhibit the findings on the study on risk factors influencing the epidemiology of DR-TB. A mixed method was used. A qualitative study of participants using the in-depth one on one interview with a grand tour question “ What are the risk factors that resulted in you having DR-TB” and probing questions. The quantitative retrospective part was utilised to review medical records. Convenience sampling was utilised to recruit participants using an interview guide to collect data and random sampling for the quantitative aspect using a checklist to collect data. Risk factors influencing the development of DR-TB were identified to be previous treatment with anti-tuberculosis drugs, human immunodeficiency virus (HIV). The findings showed that the prevalence of HIV in DR-TB was 61% for HIV positive and 39% for negative and the quantitative data showed 77% HIV positive and 23% negative to HIV. Lack of education for patients and their families on precautionary measures to take when caring for a family member, and what to do in cases of developing side effects. This study concludes that both the need to ensure that bacteriologically confirmed patients are initiated to treatment, adhere to their treatment and complete treatment and due to the number of direct cases being infected with DR-TB ensuring that infection control strategies are put in place at work and at home settings
Health Studies
M.A. (Public Health)
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Tsabedze, Bhekisisa Senzo. "Association between malnutrition and diagnosed drug susceptible tuberculosis amongst children aged zero to fifteen years old in Swaziland." Diss., 2018. http://uir.unisa.ac.za/handle/10500/25634.

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Background: In 2015, Swaziland had a tuberculosis (TB) prevalence of 733 per 100 000 population and HIV prevalence of 27.5%. Baylor College of Medicine Children’s Foundation Swaziland (BCMCFSD) reported 83% prevalence of malnutrition amongst children in 2014. No study has described the association between malnutrition and childhood TB in Swaziland. Purpose: To examine the association between malnutrition and diagnosed drug susceptible tuberculosis (TB) amongst children aged zero to fifteen years old in Swaziland. Method: The Mixed Method approach was used to conduct the study. A total of 306 children’s electronic records were extracted, then 12 children’s caregivers interviewed. Extracted data were cleaned and exported to an excel database, then analysed using STATA version 14 by a statistician. Qualitative data were analysed using NVIVO version 11 post the analysis of the quantitative data. Triangulation of quantitative and qualitative results was conducted to obtain a comprehensive picture of the study. Validity, reliability, trustworthiness and adherence to ethical considerations were maintained. Results: History of previous TB treatment, HIV status and age were strongly associated with poor TB outcome (<0.001) and severe malnutrition (<0.002). Sex, regions and TB type were statistically insignificant. Nutritional situation at home and nutritional support from the health care facility, emerged as themes. Conclusion: TB and Malnutrition are significant predictors of children mortality, thus the children caregivers need consistent health education and support.
Health Studies
M. P. H
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Dlamini, Mcebo Edwin Maswati. "The prevalence of bovine tuberculosis and associated risk factors for humans in Swaziland." Diss., 2013. http://hdl.handle.net/2263/36811.

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Bovine Tuberculosis is a chronic debilitating disease of cattle and other animals with a worldwide distribution and transmitted mainly through the inhalation of aerosols. The aim of this study was to determine the prevalence of BTB in the cattle population of selected dip tanks in Swaziland. Furthermore, the zoonotic risk to farmers whose cattle are infected with BTB was assessed by means of a questionnaire survey. Abattoir surveillance identified 16 dip tanks of study where at least 10 % of the cattle were tested for BTB using the comparative intra-dermal skin. In five of these dip tanks, the same cattle were tested for BTB using the IFN-γ Test. Eight BTB skin test positive animals were slaughtered and a detailed post mortem examination was conducted and samples collected for the isolation of M. bovis. Concurrent with BTB testing, a questionnaire survey was conducted to determine risk factors for humans. The prevalence of BTB was found to be 6.75 % in the study population and 20 % of BTB positive animals were diagnosed by both the CIST and IFN-γ, indicating a correlation for the test positive animals in the two tests. M. bovis was isolated from seven of the eight animals slaughtered. Farmers’ knowledge of BTB as a cattle disease and serious zoonosis is insufficient and inadequate while consumption practices of products of bovine origin exposes them to the risk of infection by M. bovis. There is a need to investigate the extent of M. bovis infections in the human population.
Dissertation (MSc)--University of Pretoria, 2013.
gm2014
Veterinary Tropical Diseases
unrestricted
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Nkambule, Bongi Siyabonga, and 席亞朋. "The Relationship between Patients’ Perception of Nurse Caring Behaviors and Tuberculosis Stigma among Patients with Drug-Resistant Tuberculosis in Swaziland." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/kv8bup.

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碩士
國立臺北護理健康大學
護理研究所
105
Background: Tuberculosis (TB) is a major cause of death worldwide and Swaziland is one of the countries with highest rates of TB. Patients with Drug-resistant are feared by nurses because of the infectiousness nature of the diseases and its resistance to drugs. This fear is thought to lead to poor nurse caring behaviors which patients perceive as stigma. Purpose: To examine (1) the relationship between patients’ perceptions of nurse caring and tuberculosis related stigma (2) the predictors of tuberculosis related stigma among patients with drug-resistant TB in Swaziland. Methods: In this descriptive cross-sectional study, 84 patients with drug-resistant TB completed a demographic data sheet, Lee-Hsieh at el., (2004) Caring behavior measurement and Van Rie at el., (2008) Tuberculosis related stigma scale. Results: The patients reported a poor perception of nurse caring behaviors frequency (x̅ =2.52±.41), and a high level of perceived TB related stigma (x̅ = 30.20±9.31). Only the “gender” and “monthly income” variables had a significant mean difference in nurse caring behaviors (p< .05). There were no demographic factors associated with TB related stigma. There was a significant correlation between the perception of nurse caring behaviors and TB stigma among patients with drug resistant TB (r= -.709, p< 0.01). Hierarchical Multiple Regression revealed that “Sincerity, Empathy & Respect” and “Professional caring behavior” can predict TB related stigma (F= 42.24, p< 0.01), explained variance of 52.8% with “Sincerity, Empathy & Respect” being the strongest (β = -.599). Conclusion: Nurse caring behaviors can predict how patients perceive stigma, thus emphasis on caring behaviors education on nurses is needed to reduce TB stigma among patients with drug-resistant TB. Once patients have a lower perception of stigma, they have a higher possibility of adhering to TB treatment.
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Books on the topic "Tuberculosis Swaziland"

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Swaziland. Ministry of Health and Social Welfare. and UNICEF Swaziland, eds. Signs of hope amidst times of challenge: 10th round of national HIV serosurveillance among women attending antenatal care, sexually transmitted infections clients and tuberculosis patients at health facilities in Swaziland : survey report. [Mbabane]: Kingdom of Swaziland, Ministry of Health and Social Welfare, 2006.

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