Relevant bibliographies by topics / Tubulin / Dissertations / Theses
To see the other types of publications on this topic, follow the link: Tubulin.

Dissertations / Theses on the topic 'Tubulin'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Tubulin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Nacoulma, Aminata. "Reprogrammation métabolique induite dans les tissus hyperplasiques formés chez le tabac infecté par Rhodococcus fascians: aspects fondamentaux et applications." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209429.

Full text
Abstract:
Les pathosystèmes, plante-bactérie, aboutissent souvent au niveau de la plante à de profondes reprogrammations tant au niveau de la morphogenèse que du métabolome. Dans le cas de l’interaction plante-Rhodococcus fascians, une bactérie phytopathogène, il se développe au niveau du site d’infection, une structure morphologique particulière nommée « galle feuillée ». <p>Au sein de cette hyperplasie, les altérations métaboliques induites concernent non seulement les produits du métabolisme primaire mais également le métabolisme secondaire et plus particulièrement des composés qui interviennent dans
APA, Harvard, Vancouver, ISO, and other styles
2

Mackeh, Rafah. "Mécanisme de l’hyperacétylation de la tubuline en réponse aux stress." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114852.

Full text
Abstract:
Au-delà de sa présence sur les microtubules stables, l'acétylation de l’-tubuline peut être augmentée après exposition des cellules aux UV ou après une carence en nutriments, phénomène que l’on appelle « hyperacétylation ». Cependant, le mécanisme d’induction de cette hyperacétylation est encore inconnu. Dans cette étude, nous montrons que l’hyperacétylation de la tubuline est une réponse générale aux stress cellulaire, et nous avons cherché à caractériser cette réponse, à identifier la voie de signalisation activée par le stress et conduisant à cette réponse, et à étudier la signification bi
APA, Harvard, Vancouver, ISO, and other styles
3

Cao, Luyan. "bases structurales de la motilité des kinésines." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS267/document.

Full text
Abstract:
Les kinésines sont des protéines moteur liées au cytosquelette de microtubules. Elles convertissent l’énergie provenant de l’hydrolyse de l’ATP en un travail mécanique. Leur fonction typique est de se déplacer le long du microtubule pour véhiculer des charges. La plupart des kinésines sont des dimères. Elles comprennent un domaine moteur, qui porte à la fois les sites de liaison du nucléotide et du microtubule, un domaine intermédiaire de dimérisation et une partie dite « queue » qui confère la spécificité des charges à transporter. Mon objectif est d’établir le mécanisme moléculaire à la base
APA, Harvard, Vancouver, ISO, and other styles
4

Bladh, Håkan. "Structure-activity studies of novel colchicine analogs synthesis, conformation and tublin binding /." Lund : Lund University, 1998. http://books.google.com/books?id=1sBqAAAAMAAJ.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Francisco, Samuel Nuno Furtado da Conceição. "Toxoplasma gondii Tubulin Cofactor B plays a key role in host cell invasion and replication." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Vterinária, 2020. http://hdl.handle.net/10400.5/20149.

Full text
Abstract:
Tese de Doutoramento em Ciências Veterinárias na Especialidade de Ciências Biológicas e Biomédicas<br>Tubulin cofactors participate in the folding, dimerization, and dissociation pathways of the tubulin dimer, being implicated in the control of tubulin proteostasis and consequently in the control of microtubule (MT) dynamics in vivo. We hypothesise that these proteins have a role in the regulation of MT cytoskeleton dynamics during Toxoplasma gondii host cell invasion. In this context, we characterized the Tubulin cofactor B (TBCB) in T. gondii. TBCB is a CAPGly domain-containing protein
APA, Harvard, Vancouver, ISO, and other styles
6

Imboden, Martin Alex. "Tubulin genes of Trypanosoma brucei /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Deshpande, Amit. "α-Tubulin nitrotyrosination affects cell growth and is regulated by tubulin tyrosine ligase like 12". Strasbourg, 2009. https://publication-theses.unistra.fr/restreint/theses_doctorat/2009/DESHPANDE_Amit_2009.pdf.

Full text
Abstract:
Les microtubules sont un élément important du cytosquelette et de réaliser une variété de fonctions essentielles. La diversité fonctionnelle des microtubules provient de différentes diverses - et-tubuline isotypes qui sont exprimés dans la cellule, et une vaste gamme de réversibles modifications post-traductionnelles. tyrosination Tubulin est l'un de ces modifications exécutées par la tubuline tyrosine ligase (TTL). TTL est le membre fondateur du 14 tyrosine ligase membres tubuline comme (TTLL) de la famille. Wasylyk laboratoire a trouvé TTLL12 être exprimés de manière différentielle dans la t
APA, Harvard, Vancouver, ISO, and other styles
8

Karamtzioti, Paraskevi 1990. "Tubulin modifications in human gametes : from the oocytes spindle to the sperm flagellum : Characterization of tubulin post translational modifications in female meiosis and sperm pathologies." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/670643.

Full text
Abstract:
This thesis aimed to characterize the tubulin PTM profile of human oocytes and spermatozoa. Tubulin rich structures play critical roles in the cellular behavior of human gametes. Mutations in tubulin or related proteins can affect oocyte maturation and flagellum motility. We first focused on tubulin post-translational modifications (PTMs) in the oocyte spindle and sperm flagellum. We characterized the PTM spindle profile of MII oocytes cultured in vitro and matured in vivo, and compared PTM enzyme transcript levels with two additional groups: GV and failed to mature oocytes. Further determinat
APA, Harvard, Vancouver, ISO, and other styles
9

Paul, E. C. A. "The biology of tubulin in Physarum." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371147.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Doll, John M. 1976. "Catalysis of tubulin heterodimerization in vivo." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32259.

Full text
Abstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.<br>Includes bibliographical references.<br>The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into heterodimer. The components of this pathway, tubulin cofactors, are dispensable for growth in Saccharomyces cerevisiae under laboratory conditions. Yet, these proteins are required for survival under conditions of stress or in the presence of a weakened tubuli
APA, Harvard, Vancouver, ISO, and other styles
11

Schatz, Peter Joseph. "Analysis of [alpha]-tubulin in yeast." Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/32571.

Full text
Abstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1988.<br>On t.p. [alpha] appears as the original Greek letter.<br>Includes bibliographies.<br>by Peter Joseph Schatz.<br>Ph.D.
APA, Harvard, Vancouver, ISO, and other styles
12

Abruzzi, Katharine Boyer Compton 1973. "Regulation of tubulin functions in Saccharomyces cerevisiae." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8584.

Full text
Abstract:
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.<br>Includes bibliographical references.<br>A variety of cellular factors regulate the formation of complex microtubule structures in the cell. Most of these factors modulate microtubule structures by affecting the polymerization of [alpha]/[beta]-tubulin heterodimer subunits to form microtubules. However, there is another class of factors that affect microtubule formation by regulating the steps that precede the polymerization of [alpha]/[beta]-tubulin heterodimer. One of these factors is Rbl2p. Rbl2p was originally
APA, Harvard, Vancouver, ISO, and other styles
13

Prigozhina, Natalie L. "Studying gamma-Tubulin functions in Aspergillus Nidulans /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488202678773327.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

ひとみ, 藤原, та Hitomi Fujiwara. "チューブリン恒常性の破綻がタウタンパク質に与える影響". Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13148029/?lang=0, 2020. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13148029/?lang=0.

Full text
Abstract:
タウオパチー変性神経細胞では、本来軸索に局在する微小管結合タンパク質タウが細胞体や樹状突起に蓄積するとともにチューブリン・微小管が減少する。この広範な神経細胞骨格系の変性は、タウの異常リン酸化に起因すると考えられてきた。しかし、タウの異常性獲得と微小管の消失との関係は未だ不明な状態にある。本研究では、初代培養神経細胞でαチューブリンの分子シャペロンであるTubulin-specific chaperon Eの発現抑制を行うことで、チューブリンの恒常性破綻を誘導するともに、それとタウの異常性獲得の関連性について検討した。<br>Tauopathy is a type of neurodegenerative disorder including Alzheimer's disease defined by formation of tau filamentous inclusion in neurons. Tau is a microtubule associated protein localized in axon and assumed to promote microtubule stabilization in healthy neuron. In contrast, accumulation of hyperphosphorylated tau in somatodend
APA, Harvard, Vancouver, ISO, and other styles
15

Khelifi, Ilhem. "Conception, synthèse et évaluation de nouveaux composés hétérocycliques analogues de l'isoCombrétastatine A-4 : vers des composés antivasculaires à effets secondaires amoindris." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS280.

Full text
Abstract:
La Combrétastatine A-4 (CA-4), molécule naturelle isolée d’un saule d’Afrique du sud est le chef de file des agents antivasculaire qui détruit sélectivement le réseau vasculaire tumoral et qui conduit à une nécrose ischémique d’une tumeur solide. Sa prodrogue, la fosbrétabuline (CA-4P, First-in-class) a reçu en 2016 le statut de médicament orphelin aux USA et en Europe pour le traitement de tumeurs neuro-endocrines et des glioblastomes multiformes. Malgré un intérêt thérapeutique certain, la fosbrétabuline a montré une instabilité chimique (isomérisation de la double liaison Z conduisant à l’i
APA, Harvard, Vancouver, ISO, and other styles
16

Perrin, Aurélie. "Rôle des alpha-tubulines fongiques dans la symbiose ectomycorhizienne et dans les interactions champignons plantes." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10019.

Full text
Abstract:
Les champignons ont développé diverses interactions avec les végétaux. Ces interactions peuvent être bénéfiques pour la plante dans le cas des champignons établissant des symbioses mutualistes ou néfastes si le champignon est pathogène. Elles reposent sur des mécanismes moléculaires mal élucidés. Des études réalisées sur le champignon mutualiste Hebeloma cylindrosporum associé au pin Pinus pinaster ont permis de créer une collection de mutants affectés dans leur capacité à interagir avec les plantes et à former l’organe mixte de la symbiose, l’ectomycorhize. L’objectif de ma thèse a été d’étud
APA, Harvard, Vancouver, ISO, and other styles
17

Yagdi, Efe Esma. "Analyse du rôle des dérivés de polysulfanes de l’ail dans le réseau microtubulaire et l'autophagie : l’effet anticancéreux dans le cancer colorectal." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0281/document.

Full text
Abstract:
Le cancer colorectal est une cause majeure de morbidité et de mortalité dans le monde entier. Des études épidémiologiques révèlent une corrélation inverse entre le risque de développer un cancer du côlon et un régime alimentaire riche en ail. De nombreux travaux scientifiques rapportent l'activité anti-cancéreuse des polysulfures de diallyle (PSDA) dérivés de l'ail dans divers types de cancer in vitro et in vivo. Le mécanisme d'action le mieux connu repose sur l'induction de l'arrêt mitotique suivi de l'apoptose. La tubuline est identifiée comme nouvelle cible thérapeutique des PSDA. La tubuli
APA, Harvard, Vancouver, ISO, and other styles
18

Mershin, Andreas. "Tubulin in vitro, in vivo and in silico." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/1635.

Full text
Abstract:
Tubulin, microtubules and associated proteins were studied theoretically, computationally and experimentally in vitro and in vivo in order to elucidate the possible role these play in cellular information processing and storage. Use of the electric dipole moment of tubulin as the basis for binary switches (biobits) in nanofabricated circuits was explored with surface plasmon resonance, refractometry and dielectric spectroscopy. The effects of burdening the microtubular cytoskeleton of olfactory associative memory neurons with excess microtubule associated protein TAU in Drosophila fruitflies w
APA, Harvard, Vancouver, ISO, and other styles
19

Griffith, Jennifer Kristine. "Inhibition studies of the tubulin detyrosination/tyrosination cycle." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50033.

Full text
Abstract:
Microtubules are a highly dynamic component of the cytoskeleton, which are crucial for many cellular processes. Microtubules are comprised of α/β-tubulin heterodimers, which are subject to multiple post-translational modifications including the detyrosination/tyrosination cycle. This cycle involves the removal of an RNA-encoded C-terminal α-tubulin tyrosine residue by tubulin carboxypeptidase, followed by the reattachment of the tyrosine residue by tubulin tyrosine ligase. This research project is focused on the development of an inhibitor against tubulin tyrosine ligase and tubulin carboxy
APA, Harvard, Vancouver, ISO, and other styles
20

Chen, Daici. "Phospho-regulation of gamma-tubulin in budding yeast." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107769.

Full text
Abstract:
Chromosome segregation is the crucial step for cell division in most living organisms. In order to segregate the chromosomes equally into mother and daughter cells, the cell needs to build a spindle, which comprises three major components: chromosomes, microtubules and microtubule organizing center (centrosome in animal cells or spindle pole body in fungal cells). The building and normal execution of spindle function are tightly linked to cell cycle control system. gamma-Tubulin is an evolutionally conserved protein with its canonical function as a microtubule nucleator. Here we report that ga
APA, Harvard, Vancouver, ISO, and other styles
21

Smith, D. J. "The structure and regulation of frog tubulin genes." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383948.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Law, Bernard Man Hin. "Characterisation of LRRK2-tubulin interactions in Parkinson's disease." Thesis, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532317.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Idriss, Haitham Talaat. "α-tubulin tyrosination and microtubule behaviour in vitro". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46357.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Chernov, Konstantin Grigorievich. "Interplay of YB-1 between tubulin and mRNA." Thesis, Evry-Val d'Essonne, 2008. http://www.theses.fr/2008EVRY0040/document.

Full text
Abstract:
YB-1 est un régulateur important de l’expression des gènes dans les cellules eucaryotes. En plus de son rôle dans la transcription, YB-1 joue un rôle clé dans la traduction et la stabilisation des ARN messagers. Nous avons identifié plusieurs nouveaux partenaires de la protéine YB-1 par chromatographie d’affinité à partir de différents extraits tissulaires. Parmi ces partenaires, nous avons démontré que YB-1 interagit avec la tubuline et les microtubules et stimule fortement l'assemblage des microtubules in vitro. Les microtubules assemblés en présence de YB-1 ont une ultrastructure normale, e
APA, Harvard, Vancouver, ISO, and other styles
25

Wise, Dawnne O'neal. "The (gamma)-tubulin gene family in Homo sapiens /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488193272069132.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Chernov, Konstantin Grigorievich Curmi Patrick. "Interplay of YB-1 between tubulin and mRNA." S. l. : S. l. : Evry-Val d'Essonne ; Institute of protein Research Russian Academy of Sciences RUSSIE, 2008. http://www.biblio.univ-evry.fr/theses/2008/2008EVRY0040.pdf.

Full text
Abstract:
Thèse de doctorat : Biologie cellulaire et moléculaire : Evry-Val d'Essonne : 2008. Thèse de doctorat : Biologie cellulaire et moléculaire : Institute of protein Research Russian Academy of Sciences RUSSIE : 2008.<br>Titre provenant de l'écran-titre.
APA, Harvard, Vancouver, ISO, and other styles
27

Tang, Liang. "Characterization of tubulins from parasitic nematodes (Brugia malayi, B. pahangi and Nippostrongylus brasiliensis) and comparison with mammalian brain tubulin." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75933.

Full text
Abstract:
The properties of tubulins from Brugia malayi, B. pahangi, Nippostrongylus brasiliensis and rat brain were compared. Tubulins from all nematodes and rat brain were partially purified by polylysine agarose chromatography, those of brain also by cycles of assembly/disassembly, and all by taxol-induced assembly. The tubulins were compared with respect to concentration ($ mu$g tubulin/mg soluble protein), drugs binding and isoforms. The tubulins of B. malayi and B. pahangi were similar. However, the tubulin from these filariae were different from those of N. brasiliensis. Even larger differences w
APA, Harvard, Vancouver, ISO, and other styles
28

Gherbovet, Olga. "Synthèse d'hybrides vinblastine-phomopsine." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00925057.

Full text
Abstract:
La tubuline est une protéine essentielle de la cellule. En polymérisant sous forme de microtubules, elle crée notamment le fuseau mitotique le long duquel migrent les chromosomes pendant la mitose. Les médicaments qui inhibent la polymérisation et/ou la dépolymérisation de la tubuline sont des composés majeurs de la thérapie anticancéreuse. Les vinca-alcaloïdes en sont des représentants importants. Ils induisent la mort des cellules par apoptose, en inhibant la dynamique des microtubules. D'autres molécules d'origine naturelle, comme la phomopsine A, se fixent sur la tubuline à proximité ou da
APA, Harvard, Vancouver, ISO, and other styles
29

Marzo, Más Ana. "Síntesis y evaluación biológica de análogos de colchicina." Doctoral thesis, Universitat Jaume I, 2017. http://hdl.handle.net/10803/400868.

Full text
Abstract:
Esta Tesis doctoral titulada "Síntesis y evaluación biológica de análogos de colchicina" se enmarca en el campo de la química médica. El objetivo principal es la síntesis de una serie de análogos de colchicina y su posterior evaluación biológica. En dichos análogos el residuo acetilo del átomo de nitrógeno de la colchicina es sustituido por grupos α-aminoacilo derivados de aminoácidos, por grupos acilo alifáticos de diversos tipos y por grupos aroílo. En cuanto a la evaluación biológica, se ha ensayado la citotoxicidad en diferentes líneas celulares, tanto tumorales como no tumorales, los efec
APA, Harvard, Vancouver, ISO, and other styles
30

Spain, V. "A direct interaction between the Parkinson's disease protein leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation". Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1458026/.

Full text
Abstract:
Mutations in LRRK2 are a common cause of Parkinson’s disease (PD). LRRK2 encodes leucine-rich repeat kinase 2 (LRRK2), a ROCO protein. It has an enzymatic core consisting of a Ras of complex proteins (Roc) GTPase domain and kinase domain, surrounded by protein-protein interaction regions. Pathogenic LRRK2 mutations modify activity in these enzymatic domains, but how this leads to neurodegeneration is still to be elucidated. One of the few confirmed LRRK2 interactors is tubulin, the main constituent of microtubules (MTs) and part of the cytoskeletal network. Disease-causing mutations in LRRK2 a
APA, Harvard, Vancouver, ISO, and other styles
31

McCutcheon, Sandra. "Isolation of microtubule-associated proteins from the tobacco BY-2 cytoskeleton." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327432.

Full text
APA, Harvard, Vancouver, ISO, and other styles
32

Vardy, Leah Karen Anne. "The role of fission yeast γ tubulin interacting proteins in mitosis." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248436.

Full text
APA, Harvard, Vancouver, ISO, and other styles
33

Aillaud, Chrystelle. "Modifications post-traductionnelles de la tubuline : identification des tubulines carboxypeptidases et découverte de nouveaux variants." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV049.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Westermann, Stefan. "Reinigung und Charakterisierung von Tubulin Polyglutamylase aus Crithidia fasciculata." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964255537.

Full text
APA, Harvard, Vancouver, ISO, and other styles
35

Cushion, Thomas David. "Tubulin genes in human disorders of cerebral cortex development." Thesis, Swansea University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678290.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

au, ngiles@anhb uwa edu, and Natalie Giles. "Exploitation of the Protein Tubulin For Controlling African Trypanosomiasis." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060315.191003.

Full text
Abstract:
This thesis presents the results of an investigation into the structural protein, tubulin, as a potential target for anti-trypanosomatid drug discovery and vaccine development. Recombinant alpha- and beta- tubulin proteins from Trypanosoma brucei rhodesiense were expressed as soluble fusion proteins in an E. coli expression system. The recombinant alpha- and beta- tubulins were used to determine the nature of binding of novel trifluralin analogues EPL-AJ 1003, 1007, 1008, 1016 and 1017. Native tubulin from rats was used to determine the extent of binding to mammalian tubulin. The results of th
APA, Harvard, Vancouver, ISO, and other styles
37

Giles, Natalie Lydia. "Exploitation of the protein tubulin for controlling African trypanosomiasis /." Access via Murdoch University Digital Theses Project, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060315.191003.

Full text
APA, Harvard, Vancouver, ISO, and other styles
38

Rogers, David Howard. "Analysis of the rat Tal a-tubulin gene promoter." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36831.

Full text
Abstract:
The mature nervous system is composed largely of two cell types, glial cells and postmitotic neurons. All postmitotic neurons of the mature nervous system derive from proliferating neural precursor cells. To generate a neuron, a precursor must cease dividing and express a number of genes that are characteristic of the neuronal phenotype. How these changes in cell behaviour and phenotype are brought about in mammals is still poorly understood.<br>This thesis describes experiments that were designed to explore cell intrinsic mechanisms regulating the generation of neurons from neural precursor c
APA, Harvard, Vancouver, ISO, and other styles
39

Gong, Zhiyuan. "Regulation of tubulin gene expression in sea urchin embryos." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74267.

Full text
Abstract:
Regulation of tubulin gene expression in embryos of the sea urchin Lytechinus pictus has been experimentally investigated by use of cloned recombinant tubulin DNA and anti-tubulin antiserum. Tubulin synthesis appears to be autogenously regulated at the level of tubulin mRNA stability by the level of unpolymerized tubulin; i.e., the more unpolymerized tubulin, the less stable the tubulin mRNA. Destabilization of tubulin mRNA requires continued protein synthesis. Most of tubulin stored in eggs is unpolymerized; during embryogenesis the mass of tubulin per embryo changes little, but unpolymerized
APA, Harvard, Vancouver, ISO, and other styles
40

Pireddu, Roberta. "New anticancer drugs : targeting tubulin and signal transduction pathways." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54618/.

Full text
Abstract:
The main aim of the study described in this thesis is the development of new anticancer agents. The first chapter is a general introduction to cancer, and the development of chemotherapy anticancer agents during the course of the years. The following four chapters briefly introduce the biological targets in the authors study. Chapter Two describes a general introduction to tubulin and microtubules as anticancer targets. A discussion of those compounds most relevant to this thesis is provided. Chapter Three describes Signal Transducers and Activator of Transcription 3 (STAT3) proteins, their ro
APA, Harvard, Vancouver, ISO, and other styles
41

Yoon, Yisang. "Studies on tubulin expression and purification in Aspergillus nidulans /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu148784237289608.

Full text
APA, Harvard, Vancouver, ISO, and other styles
42

Kojima, Yasushi. "Suppression of tubulin polymerization by the LKB1-MARK signaling." Kyoto University, 2007. http://hdl.handle.net/2433/135913.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Holmfeldt, Per. "Regulation of tubulin heterodimer partitioning during interphase and mitosis." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1923.

Full text
APA, Harvard, Vancouver, ISO, and other styles
44

Giles, Natalie. "Exploitation of the protein tubulin for controlling African trypanosomiasis." Thesis, Giles, Natalie (2005) Exploitation of the protein tubulin for controlling African trypanosomiasis. PhD thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/40/.

Full text
Abstract:
This thesis presents the results of an investigation into the structural protein, tubulin, as a potential target for anti-trypanosomatid drug discovery and vaccine development. Recombinant alpha- and beta- tubulin proteins from Trypanosoma brucei rhodesiense were expressed as soluble fusion proteins in an E. coli expression system. The recombinant alpha- and beta- tubulins were used to determine the nature of binding of novel trifluralin analogues EPL-AJ 1003, 1007, 1008, 1016 and 1017. Native tubulin from rats was used to determine the extent of binding to mammalian tubulin. The results of th
APA, Harvard, Vancouver, ISO, and other styles
45

Giles, Natalie. "Exploitation of the protein tubulin for controlling African trypanosomiasis." Giles, Natalie (2005) Exploitation of the protein tubulin for controlling African trypanosomiasis. PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/40/.

Full text
Abstract:
This thesis presents the results of an investigation into the structural protein, tubulin, as a potential target for anti-trypanosomatid drug discovery and vaccine development. Recombinant alpha- and beta- tubulin proteins from Trypanosoma brucei rhodesiense were expressed as soluble fusion proteins in an E. coli expression system. The recombinant alpha- and beta- tubulins were used to determine the nature of binding of novel trifluralin analogues EPL-AJ 1003, 1007, 1008, 1016 and 1017. Native tubulin from rats was used to determine the extent of binding to mammalian tubulin. The results of th
APA, Harvard, Vancouver, ISO, and other styles
46

Hage-Sleiman, Rouba. "Impact of tululin binding cofactor C (TBCC) on microtubule mass and dynamics, cell cycle, tumor growth and response to chemotherapy in breast cancer." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10085/document.

Full text
Abstract:
La mise en conformation de l’α et β tubulines en hétérodimeres polymérisables nécessite l’intervention de cinq protéines « Tubulin Binding Cofactors » (TBCA a TBCE) dont TBCC qui joue un rôle indispensable. Dans des cellules humaines d’adénocarcinome mammaire, nous avons modifié le niveau d’expression de TBCC et nous avons montre que ceci avait un impact sur le contenu des fractions de tubuline, la dynamique des microtubules ainsi que sur le phénotype et chimiosensibilité des cellules. La distribution en cycle cellulaire et les durées de la mitose et de la phase S ont été altérées. La modifica
APA, Harvard, Vancouver, ISO, and other styles
47

Bobba, Viharika. "SULFONAMIDE DERIVATIVES AS TUBULIN INHIBITORS AND SELECTIVE ANTI-TRYPANOSOME AGENTS – DESIGN, SYNTHESIS & BIOLOGICAL EVALUATION." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1468241198.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

Joe, Patrick Allen. "A structure-function study of the cysteines and carboxy-terminal tail domain of the beta-III tubulin isotype a dissertation /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=43&CISOBOX=1&REC=18.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Arnold, Matthew Scott. "Characterization of the thermostable nature of the alpha and beta tubulin proteins in Cyanidium caldarium and Cyanidioschyzon merolae." Thesis, [Blacksburg, Va. : University Libraries, Virginia Polytechnic Institute and State University, 2004. http://scholar.lib.vt.edu/theses/available/etd-03222004-144731.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

Hodgkinson, Julie L. "The effect of ligands on the assembly of tubulin polymers." Thesis, Liverpool John Moores University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292340.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Tubulin' for other source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography