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1
Babu, H. Rajendra. "Health Information Seeking Behaviour of Postgraduate Students at Tumkur University, Tumakuru, Karnataka." Pearl : A Journal of Library and Information Science 12, no. 3 (2018): 216. http://dx.doi.org/10.5958/0975-6922.2018.00027.x.
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Raviivvenkat, B. "Postgraduate Science Students’ Perception on Facilities and Services of Tumkur University Library." Indian Journal of Information Sources and Services 8, no. 3 (2018): 52–57. http://dx.doi.org/10.51983/ijiss.2018.8.3.549.
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Libraries always faced the challenge of the existing trend and able to cope with it. Whether it was microform, microfiche, CD-ROM and Database, library has used this format to provide the information. The Digital Technology has open up new challenges and opportunities and Librarians as the custodian are already imbibed these technologies as an assist medium and are able to reach the clients. University Library always is in the forefront to use the new coming learning objects. The ICT revolution and Network world has opened up abundance in providing resources to the users and also changed landscape of the existing organisation. This study is on perception of postgraduate student’s perception about the University Library. The sample population consisted of 150 among which 104(69%) responded to the structured query. The identified aspect in the study is that Library needs a separate building and users are satisfied with facilities and services but demanding more resources and updating.
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Saravana, K., Lokesha M. U. Dr., and B. P. Shivalingappa Dr. "Impact of Facebook Addiction on the Study Habits of Social Work Students with Special Reference to Tumkur District." International Journal of Trend in Scientific Research and Development 2, no. 1 (2017): 1479–81. https://doi.org/10.31142/ijtsrd8219.
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The intention of this research was to inspect the amount of social work students addiction in using Facebook, the amount of their study habits such as management of time, competency in attending test, note taking, reading, writing, field work practice, report writing, presentation of class seminar, participation in group discussion in the class and if correlation exists between the two. Researchers used the Bergen Facebook Addiction Scale BFAS , it contains the six important elements of addiction such as salience, mood modification, tolerance, withdrawal, conflict, and relapse and the Study Habits Questionnaire SHQ were used to 123 Social work students from different post graduate colleges affiliated under Tumkur University. SPSS and Excel used to compute data, researchers adopted correlation and simple percentile statistical test to examine impact of facebook addiction. The Social work students studying in different colleges in Tumkur University have largely high degree of addiction in Facebook. On the other hand they are found to exhibit low extent of practicing study related activities. Correlation analysis revealed significant yet positive coefficient values of the six Facebook addiction elements with overall study habits. Findings can be used Social work educators by integrating it in classroom activities. At the same time this study is path way for further studies with bigger scope and inclusion of demographic variables in estimating Facebook addiction, social network or online addiction are recommended. Saravana K | Dr. Lokesha M. U | Dr. B. P. Shivalingappa "Impact of Facebook Addiction on the Study Habits of Social Work Students: with Special Reference to Tumkur District" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-1 , December 2017, URL: https://www.ijtsrd.com/papers/ijtsrd8219.pdf
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Raviivvenkat, B., and B. Subash Reddy. "An Analysis of Research Contributions of Tumkur University Based on JGate Plus (JCCC)." SRELS Journal of Information Management 56, no. 6 (2019): 321. http://dx.doi.org/10.17821/srels/2019/v56i6/149376.
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B N, Hemavathi, and Rajeshwari N. "Scholars’ Perception on Ethical Use of Digital Information: A Study at Tumkur University-." Journal of Information Organization 14, no. 4 (2024): 176–81. https://doi.org/10.6025/jio/2024/14/4/176-181.
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Simon, Simi, Ravikiran K.M, Gowrishankar B.S, and Asiya Nuzhat F.B. "EVALUATION OF ECONOMIC TRAITS OF THREE SELECTED MULBERRY SILKWORM RACES FOR COMMERCIAL PURPOSE." International Journal of Advanced Research 12, no. 03 (2024): 108–14. http://dx.doi.org/10.21474/ijar01/18370.
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Sericulture is a cottage industry par excellence. It is one of the most labour intensive sectors of the Indian economy combining both agriculture and industry. The present study was carried out in Zoology Research laboratory, Tumkur University. Three different mulberry silkworms (Bombyx mori) races viz., FC1, FC2 and FC1×FC2 were selected to conduct the experiments, were fed with V1 mulberry leaves. Theaim of the experiment was to know the comparison of commercial charactersof three selected silkworms races viz., cocoon ratio, larval growth and silk filament. So, the present work would be helpful in rearing technology and better crop yield and management.
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Raviivvenkat, B. "Information Literacy Level at Tumkur University: A Comparative Study Among Students of Social Science and Sciences." Pearl : A Journal of Library and Information Science 13, no. 1 (2019): 21. http://dx.doi.org/10.5958/0975-6922.2019.00004.4.
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Kumara, B., and B. T. Sampath Kumar. "Impact of ICT on Reading Habits of Students: A Survey." Asian Journal of Information Science and Technology 8, no. 1 (2018): 75–79. http://dx.doi.org/10.51983/ajist-2018.8.1.160.
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This paper examines the impact of ICT on the reading habits of the students of Tumkur University. The survey was conducted using a well design and structured questionnaire. A total of 440 postgraduate students of faculty of Arts, Science and Commerce were chosen. The result of this study showed that most of the students are female (61.6%) and most of them (72.3%) are from rural areas. The study found that students read books daily at home (69.5%) followed by classroom (51.1%). The students strongly agreed that the print books are costlier than Internet sources (32.3%). The study results also indicated that students are accessed Internet every day and the students used ICT in support of their academic work. The study recommends that the university authorities in to provide more ICT facilities to all the postgraduate students. It is also necessary to conduct more ICT based learning programmes to the students.
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H., Rajendra Babu. "Awareness of Copyright and its Policies among the PG Teaching Faculty: A Study." Indian Journal of Information Sources and Services 8, no. 3 (2018): 26–32. http://dx.doi.org/10.51983/ijiss.2018.8.3.552.
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Copyright is a form of intellectual property protection granted under Copyright Act to the creators of original works of authorship. Libraries are the backbone of any organization or an institution. Alongside, libraries are also the torch bearers, in the creating awareness of the IPR aspects to its user community. A study on finding the awareness levels in the area of intellectual property rights in general and copyright in specific is the need of the hour in the universities, as they grooming the next generation of workers happens in there. Here is a study aimed at to see how the faculties in the university are aware of copyright and its implications. There are a total of 62 respondents participated in the survey. The data has been analyses and interpreted accordingly and presented in the form of tables and figures suitably. The study has dwells in detail about Awareness on copyright, Purpose of using the copyrighted material, Awareness on copyright policies and on type of the copyrighted material, Knowledge on copyright, Awareness on Indian copyright act 1957, Views on copyright protection for their work, Safeguarding the interest of copyright owners and Understanding on the IP concepts among the teaching community. The study focuses on Awareness on copyright, use of copyright, to access the user level of knowledge on copyright and awareness on implications of copyright violation for self-learning, research as well as teaching among the faculty members of Post-Graduation Departments of Tumkur University, Tumakuru.
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Radhakrishna, Veerabhadra, Santhosh Ramakrishna, Ravi H. Kudthni, Shrinidhi Kulkarni, and Meghana Panchakshari. "Knowledge, attitude, and practice on HPV vaccination among pre-university female students." Panacea Journal of Medical Sciences 14, no. 2 (2024): 388–94. http://dx.doi.org/10.18231/j.pjms.2024.069.
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Despite the availability of the HPV vaccine in our country, the mortality secondary to cervical cancer is still high as not many are interested in vaccinating the at-risk population. Hence, a study was conducted to identify the knowledge, attitude, and practice of the Human papilloma virus (HPV) vaccination in pre-university female students.A cross-sectional study was conducted in the Tumkur district of India amongst female students studying in pre-university colleges. A total of 271 female students were included in the study. The mean knowledge score of the study population was 5.6/17 and only 169 (62%) students were aware of the effects of HPV. A total of 144 (53%) study participants were willing to take HPV vaccination if provided but 1/3 of them backed out after knowing the cost of vaccination. The study participants from the urban area had more knowledge about the effects of HPV (118/160 vs. 51/111; p <0.0001) than those from the rural area but there was no difference between them regarding attitude and practice toward HPV infection and its vaccination. The study population was found to have poor knowledge about HPV infection and HPV vaccination. Only 53% of study participants were willing to take HPV vaccination if provided but 1/3 of them backed out after knowing the cost of vaccination. The urban group was more knowledgeable than the rural group but both groups had a similar attitude and practice toward HPV infection and its vaccination.
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Dr., Kumara B. "Use of e-Resources among Economically Backward Students: A Survey." International Journal of Advance and Applied Research 10, no. 1 (2022): 450 to 456. https://doi.org/10.5281/zenodo.7204584.
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<em>The present study aims to explore the use of e-resources among economically backward students. </em><em>A total of 219 samples were selected from various Post-Graduate departments of Tumkur University, Karnataka. </em><em>The study found that most of the male (63.92%) and (36.07%) female respondents used e-resources. The majority of respondents (94.1%) used e-resources in the library daily. The result shows that ma 55.7% of respondents used e-newspapers compared to other e-resources. </em><em>It is very interesting to note that the most of respondents used e-resources to study course materials (84.9%). </em><em>The notable findings of the study found that 100% of the respondents preferred PDF file format. The respondents were asked to mention the use of various search engines, but it is surprised note that 100% of the respondents used Google. Further, the study reveals that most of the students have a positive attitude towards the use of e-resources. </em>
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Tse, Andrew, Russel Knaus, and Edward Tse. "Laparoscopic partial nephrectomy: the University of Saskatchewan (Regina division) experience." Canadian Urological Association Journal 3, no. 2 (2013): 111. http://dx.doi.org/10.5489/cuaj.1037.
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Purpose: Open partial nephrectomy (OPN) is now the preferredtreatment for most T1a and selected T1b tumours. Laparoscopicpartial nephrectomy (LPN), created to reduce the morbidity associatedwith OPN, is now a viable option when performed by experiencedlaparoscopic surgeons. We retrospectively review ourLPN experience and propose a new parameter, the LPN utilizationrate (LPN-UR), defined as the probability of any referredpatient with a T1 tumour undergoing LPN before the surgeon’sknowledge of its imaging characteristics, to define the role of LPNat our institution.Methods: Between March 2003 and August 2008, 47 consecutivepatients underwent LPN for T1 tumours. All patients underwenttransient en bloc vascular occlusion of the renal hilum forcold-scissor tumour excisions. Preoperative, intraoperative, postoperativeand pathological data were collected. The LPN-URs for2005, 2006, 2007 and 2008 were calculated.Results: There were 31 nonhilar tumours and 16 hilar tumours. Allprocedures were completed laparoscopically. Mean tumour size was3.8 (range 1.5–7.2) cm. Mean operating time was 2.8 (range 1.2–4.5)hours. Mean hospital stay was 5.2 (range 2.0–15.0) days. Mean warmischemic time (WIT) was 32.7 (range 14.2–50.4) minutes. Six patients(12.8%) received blood transfusions and 1 patient required an emergencynephrectomy for bleeding. One patient developed urinaryleakage. One patient developed a late calyceal stricture. Mean postoperativedifferential renal function was 35%:50%. Median follow-up was 18 months. Pathological examination of all tumoursrevealed 38/47 (80.9%) malignant tumours with 2 positive surgicalmargins (4.3%). The LPN-URs for 2005, 2006, 2007 and 2008were 50%, 54%, 63% and 93%, respectively, for all T1 tumours.Conclusion: Laparoscopic partial nephrectomy can be safely performedand used for treatment of most T1 tumours referred to ourinstitution. Long-term follow-up will be required to determine theoncological efficacy of LPN. Every effort should be made to furtherreduce the WIT. The LPN-UR is a useful parameter for consultingreferring physicians and patients.Objectif : La néphrectomie partielle ouverte (NPO) constitueactuellement le traitement de choix pour la plupart des cas detumeurs T1a et de certaines tumeurs T1b. La néphrectomie partiellelaparoscopique (NPL), technique développée pour réduirela morbidité associée à la NPO, représente maintenant une optionintéressante pour les chirurgiens expérimentés en laparoscopie.Nous avons fait une analyse rétrospective de notre expérienceavec la NPL et nous proposons un nouveau paramètre — le tauxd’utilisation de la NPL (TU-NPL) — afin de mieux définir le rôlede cette technique dans notre établissement.Méthodologie : Entre mars 2003 et août 2008, 47 patients consécutifsont subi une NPL pour traiter une tumeur T1. Tous les patientsont subi un clampage temporaire en bloc des vaisseaux rénauxau niveau du hile en vue d’une excision tumorale à froid parciseaux. Des données opératoires et pathologiques ont été recueilliesavant, pendant et après l’intervention. Les TU-NPL pour 2005,2006, 2007 et 2008 ont été calculés.Résultats : On a relevé 31 tumeurs non hilaires et 16 tumeurshilaires. Toutes les interventions ont été effectuées par laparoscopie.La taille moyenne des tumeurs était de 3,8 (écart : 1,5 à7,2) cm. Le temps moyen passé en salle d’opération était de 2,8(écart : 1,2 à 4,5) heures. La durée moyenne de l’hospitalisationétait de 5,2 (écart : 2,0 à 15,0) jours. La durée moyenne de l’ischémiechaude était de 32,7 (écart : 14,2 à 50,4) min. Six patients(12,8 %) ont reçu des transfusions sanguines et un patient a dûsubir une néphrectomie d’urgence en raison d’une hémorragie.Un patient a présenté une incontinence urinaire et un autre, unesténose tardive au niveau des calices. La fonction rénale différentiellemoyenne après l’opération était de 35 % : 50 %. La duréemédiane du suivi était de 18 mois. L’analyse pathologique a révéléque 38 tumeurs sur 47 (80,9 %) étaient malignes; 2 tumeurs (4,3 %)présentaient des marges chirurgicales positives. Les TU-NPL pour2005, 2006, 2007 et 2008 étaient respectivement de 50 %, 54 %,63 % et 93 % pour les tumeurs T1.Conclusion : La NPL peut être effectuée sans danger et utilisée pourle traitement de la plupart des cas de tumeurs T1 traités par notreétablissement. Un suivi à long terme est nécessaire pour déterminerl’efficacité oncologique de la NPL. Tous les efforts doiventêtre déployés pour réduire davantage la durée de l’ischémiechaude. Le TU-NPL est un paramètre de consultation utile pourles médecins et les patients.
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Sunil, K. Nadakatta, and Chandrappa N. "RELATIONSHIP BETWEEN SELECTED PHYSICAL FITNESS AND SERVING SKILL PROFICIENCY AMONG INTER UNIVERSITY LEVEL MALE VOLLEYBALL PLAYERS." Shanlax International Journal of Arts, Science and Humanities 6, S2 (2019): 210–14. https://doi.org/10.5281/zenodo.2632892.
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<em>Ball games require comprehensive ability including physical, technical, mental and tactical abilities. Volleyball s key components of fitness are muscular power, agility and speed. It is an anaerobic sport and only uses short bursts of energy. The service has become the team’s preeminent offensive weapon; it is capable of causing a range of problems for the receiving team, restricting, forestalling and even eliminating the possibility of an effective attack on the part of the opponents. This research will sought to determine which physical fitness and these are correlated with serving skill proficiency of volleyball male players. The purpose of the study is to determine the physical fitness and serving skill proficiency of volleyball players and to know the relationship of serving skill proficiency of volleyball players with selected physical fitness variables. In order to achieve the aim of the study, 60 (sixty) inter university level male Volleyball players of different universities (Bangalore University, Karnataka University, Kuvempu University, Mangalore University and Tumkur University) were selected as the subjects who were represented at South Zone Volleyball Tournament. Twelve players from each university were selected and their age of the subjects were ranged from 18-25 years. The serving skill proficiency was studied as dependent variable by assessed by using AAHPER Serving Test and physical fitness variables such as aerobic endurance measured by 1500 Meters run test; speed measured by 30 Meters run test; agility measured by 6 x 10 Meters Shuttle Run; Strength measured by Sergeant Vertical Jump and Trunk Flexibility measured by Sit & Reach Test are considered as independent variables to know the relationship among them. The Karl Pearson’s Product Moment Coefficient of Correlation was used to find out the relationship between Serving Skill Proficiency and selected physical fitness variables. The level of significance was fixed at 0.05 and 0.01 levels. The result concludes that there was significant correlation between physical fitness variables (aerobic endurance, agility and trunk flexibility) and serving skill proficiency of male volleyball players. A volleyball player can excel in serving if he has good aerobic endurance (‘r=0.337), agility (‘r’=0.341); and trunk flexibility (‘r’=0.22). The physical fitness and serving skill proficiency cab be improved through varied training protocols such as resistance and plyometric training.</em>
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Krishna, Chandana, and B. Manoj Babu. "Hepatitis B coverage and its awareness among medical, dental, and nursing students of a health university in Tumkur Karnataka – A cross-sectional study." Journal of Dr. YSR University of Health Sciences 13, no. 4 (2024): 348–52. https://doi.org/10.4103/jdrysruhs.jdrysruhs_171_23.
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ABSTRACT Background: Hepatitis B is a well-known global public health problem. Globally, 360 million people are chronically infected, of whom almost one million people die annually of hepatitis B virus (HBV)-related liver disease. Health care workers are at high occupational risk of HBV infection due to their potential contact with blood or body fluids and possible needle stick injuries. Since students of health professions (medical, nursing, and paramedical) are future health care workers that are early exposed to the risk of HBV infection during their clinical training, it is essential to know their vaccination coverage and awareness regarding hepatitis B infection. Objective: (1) To assess the coverage of hepatitis B vaccination among medical, dental, nursing, and paramedical students of Sri Siddhartha Academy of Higher Education. (2) To find out the reason for their non-vaccination/or partial vaccination. (3) To assess the awareness regarding hepatitis B among study subjects. Methods: A cross-sectional study among the medical, dental, nursing, and paramedical students of Sri Siddhartha Academy of Higher Education between February 2021 and August 2023. A pre-tested self-administered questionnaire was used for data collection through an online survey method. A total of 554 students responded to the online survey. Results: Hepatitis B coverage among the study subjects was 29.4%. 28.2% were partially immunized and 42.4% were unimmunized. Reason for not immunizing was lack of awareness regarding the need for vaccination (40.3%) and postponement till another time (40.3%). Awareness regarding hepatitis B was 89.9%. Conclusion: Coverage of hepatitis B vaccination was poor. Even though the awareness of hepatitis B was good, practice was poor.
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TAC, Dibingue. "What about the Intradiverticular Bladder Tumours at Ibn Rochd University Hospital?" Open Access Journal of Urology & Nephrology 7, no. 1 (2022): 1–6. http://dx.doi.org/10.23880/oajun-16000199.
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Introduction: Bladder diverticula are urothelium herniations that pass through the bladder muscle. The perivesical fat is in direct contact with the urotheliumdiverticularis. As a result, tumours developing from the urotheliumdiverticularis have a distinct evolutionary history from classical bladder tumours and are rarely linked with a bad prognosis. Objective: To assess the management of intraverticular bladder tumours. Material and Methods: This is a retrospective study on intradiverticular bladder tumours from January 2012 to December 2017 (i.e. 6 years) at the urology department of Casablanca’s UH Ibn Rochd. The study included all patients with an intradiverticular bladder tumour and a complete file. Results: The mean age was 63.75 years (with extremes of 44 and 88 years) and the The delay between the onset of symptoms and the consultation was 12.83 months. In all cases, hematuria was the most common symptom for consultation. Smoking (66.66 percent) and recurrent urethritis were identified as two risk factors (16.67 percent). In 50% of the patients, ultrasound revealed a diverticulum with tumour material, and CT scans revealed a tumorous diverticulum in 6 cases. Urothelial carcinoma was the most frequent histological type (83.33 percent), followed by squamous cell carcinoma (16.67 percent). After surgery, the pT3 grade was the most prevalent. In three and nine cases, surgery was conservative and radical, respectively. After three years of follow-up, the majority of patients had a favourable outcome with no recurrence. Conclusion: Intraverticular bladder tumours differed from classical bladder tumours in that they had a higher frequency of T3a tumours and non-urothelial carcinomas, as well as a risk of underestimated extension and tumour multifocality. In the majority of cases, their prognosis is bleak.
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Ramakrishna, Santhosh, Waseem Anjum, Veerabhadra Radhakrishna, Ravi Kudthni, and Pooja Vishwanath. "Impact of Health Education on Knowledge, Attitude, and Practice towards Human Papilloma Virus and its Vaccination." Perspectives in Medical Research 12, no. 3 (2024): 22–28. https://doi.org/10.47799/pimr.1203.05.
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Abstract Background: Despite the recommendation, the rate of Human Papilloma Virus (HPV) vaccine uptake is poor in developing countries. The possible reasons for this could be limited knowledge, poor acceptance, safety concerns, cost of the vaccine, and lack of awareness. Hence, a study was conducted to determine the effect of health education on knowledge, attitude, and practice toward HPV infection and its vaccination.Methods: An interventional study was conducted in the Tumkur district of India amongst female students studying in pre-university colleges. A questionnaire was provided to evaluate the knowledge, attitude, and practice about HPV infection and vaccination before and after health education.Results: After the health education, awareness about the effects of HPV and the mode of transmission of HPV increased from 62% to 71% (p<0.001) and 12% to 41% (p<0.001) respectively. Health education also increased knowledge about the availability of vaccination against HPV (34% to 87%; p<0.001), the population at risk for HPV infection (16% to 35%; p<0.001), the ideal age group for HPV vaccination (45% to 90%; p<0.001), and the overall knowledge score (5.6/17 to 12/17). Health education improved the willingness to pay for the vaccination from 34% to 56% (p<0.001) and the willingness to recommend others to vaccinate from 61% to 89% (p<0.001). Conclusion:The health education increased awareness about the symptomatology, mode of transmission, population-at-risk, and the effects of HPV infection. Health education also improved the willingness to pay for the vaccination and willingness to recommend others to vaccinate against HPV.
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Sanni, Daniel A., Sunday S. Soyemi, Abiodun O. Popoola, and Kabiru A. Rabiu. "Morphological spectrum and epidemiological profile of ovarian tumours in black West African women at Lagos state university teaching hospital, Ikeja, Nigeria." International Journal of Research in Medical Sciences 8, no. 6 (2020): 2067. http://dx.doi.org/10.18203/2320-6012.ijrms20202245.
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Background: This study was done to evaluate the histological types, frequency and age distribution of ovarian tumours in Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos State. This study also aims to classify ovarian tumours in this centre according to the World Health Organisation (WHO).Methods: A retrospective, descriptive hospital study of all ovarian specimens that were sent to the department of pathology and forensic medicine, LASUTH between 1st January, 2011 and 31st December, 2019 was done. Relevant data composed of the age distributions and histopathological types were extracted from the departmental information system and filed documents. The data was analysed using the IBM-SPSS version 25.0.Results: There were 198 cases of ovarian tumours. The mean age at diagnosis of ovarian tumours was 34.6±15.3 years. Unilateral ovarian tumour was observed in 91.9%% of cases while bilateral disease was seen in 8.1%. Primary ovarian tumours constitute 97.0% of all diagnosed tumours of the ovary. Germ cell tumour was the most frequently diagnosed ovarian tumour; and teratoma was the most common, representing 91.2% of germ cell tumours and 47.0% of all ovarian tumours. Primary ovarian cancer peaked at the 6th decade of life and metastatic ovarian cancer was infrequently seen. Serous carcinoma is the most commonly diagnosed ovarian cancer.Conclusions: Ovarian tumour presents most frequently at the 4th decade of life, and germ cell tumour is the most common.
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Nguyen Van, Mao, and Dong Tran Nam. "HISTOPATHOLOGY OF THE PIGMENTED TUMORAL-LIKE LESIONS OF THE SKIN AT HUE HOSPITAL OF MEDICINE AND PHARMACY UNIVERSITY." Volume 8 Issue 4 8, no. 4 (2018): 65–69. http://dx.doi.org/10.34071/jmp.2018.4.9.
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Background: Pigmented tumour of the skin is one of the common tumour in human including the benign pigmented tumours (more common) called Nevi tumours and the malignant one called melanoma which was less frequent but the most poor in prognosis. In addition, the others not belonging to these group had the same clinical appearance, so the application of histopathology and immunohistochemistry for the definitive diagnosis was indespensible. Objectives: 1. To describe the macroscopic features of the pigmented tumoral-like lesions; 2. To classify the histopathologic types of the pigmented cell tumours and the other pigmented tumours of the skin. Materials and Method: Cross-sectional research on 55 patients diagnosed as pigmented tumoral lesions by clinician, then all definitively diagnosed by histopathology combining the immunohistochemistry in difficult cases. Results: There was no difference in gender, the disease was discovered most common in adult, especially with the age over 51 years old (58.1%). the most region located was in the face accounting for 60%, following the trunk and limbs (14.6%, 12.8% respectively). All 3 malignant melanomas happened in foot. The most common color of the lesions was black (65.4%), the other ones were rose, grey and blue. Histopathology and immunohisthochemistry showed that the true pigmented cell tumours were 52.6% encompassing benign ones (Nevi tumour) (41.8%), melanoma (5.4%) and lentigo (5.4%). 47.4% was not the true pigmented cell tumour including pigmented basocellular carcinoma (36.4%) and the others less common as histiofibromas, acanthoma and papilloma. Conclusion: the pigmented tumoral-like lesions of the skin could be the true pigmented cell tumours and the others, so the application of the histopathology and the immunohistochemistry after the clinical discovery helps to determine and classify the disease definitely and for the best orientation of treatment as well. Key words: skin tumour, benign pigmented tumour (Nevi), malignant pigmented tumour (melanoma), pigmented basocellular carcinoma
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Karki, Diksha, Abhimanyu Jha, Shreya Shreevastav, and Dinesh B. Pokhrel. "Histopathological evaluation of tumours and tumour like lesions of skin and adnexa." Journal of Pathology of Nepal 8, no. 2 (2018): 1353–59. http://dx.doi.org/10.3126/jpn.v8i2.20873.
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Background: Tumours and tumour like lesions of skin have overlapping clinical presentation and sometimes pose a diagnostic difficulty on clinical ground alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be treacherous and may require ancillary tests such as Immunohistochemistry.Materials and Methods: The study was conducted at Department of Pathology of Tribhuvan University Teaching Hospital. It was a one year prospective study which enrolled 238 cases of skin biopsies after histopathological confirmation of tumours and tumour like lesions. The specimens were processed by standard method and Hematoxylin and Eosin stained sections were examined. Data entry and analysis was done by using SPSS 20 version.Results: Epidermal cyst was commonest lesion (11.8%). Among benign tumours squamous papilloma was most frequent while Pilomatricoma and Spiradenoma were most common adnexal tumour. Squamous cell carcinoma constituted 41.8% and was commonest malignant tumour followed by basal cell carcinoma (30.2%). Benign tumours were common in 11-30 years of age, malignant tumours in 61-80 years of age while tumour like lesions were common in 21-30 years of age.Conclusion: Squamous papilloma and squamous cell carcinoma was the most common benign and malignant tumour respectively. Benign adnexal tumours exceeded malignant one and were seen in third decade of life. Epidermal cyst was the commonest tumour like lesions followed by dermoid cysts.
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Steger, Christina Maria, Thomas Hager, and Elfriede Ruttmann. "Primary Cardiac Tumours: A Single-Center 41-Year Experience." ISRN Cardiology 2012 (June 27, 2012): 1–7. http://dx.doi.org/10.5402/2012/906109.
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Primary cardiac tumours are extremely rare with the most commonest being left atrial myxomas. In general, surgical resection is indicated, whenever the tumour formation is mobile and embolization can be suspected. Within 17280 patients receiving heart surgery at the Innsbruck Medical University, 78 patients (0.45%) underwent tumourectomy of primary cardiac tumours. The majority of patients (63) suffered from a left or right atrial myxoma, 12 showed a papillary fibroelastoma of the valves at echocardiographical or histological examination, 1 suffered from a hemangioma, 1 from a chemodectoma, and another one from a rhabdomyosarcoma. The mean age of cardiac tumour patients was 54.29 ± 13.28 years (ranging from 18 to 83 years). 67.95% of the patients were female and 32.05% were male. The majority of tumours were found incidentally; 97.44% of the patients showed no tumour recurrence.
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Chijiwa, H., T. Mihoki, B. Shin, K. Sakamoto, H. Umeno, and T. Nakashima. "Clinical study of parapharyngeal space tumours." Journal of Laryngology & Otology 123, S31 (2009): 100–103. http://dx.doi.org/10.1017/s0022215109005180.
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AbstractThis study reviewed 24 cases of parapharyngeal space tumour treated at Kurume University Hospital between 1990 and 2007. Histological diagnoses were generally obtained from the excised tumour (22/24). Seventy-seven per cent of the parapharyngeal space tumours were benign and 23 per cent were malignant. Thirty-eight per cent (eight of 22) of these tumours were pleomorphic adenomas and 23 per cent (five of 22) were schwannomas. A transparotidectomy and transcervical approach were used in 88 per cent (15/17) of benign tumours. A mandibular swing approach was used for one malignant tumour. Post-operative complications were identified in 16 of 22 patients. The most common complication, facial nerve paralysis, was identified in eight patients, and seven of these patients demonstrated first bite syndrome. In consideration of the high incidence of post-operative complications, the surgical approach should therefore be carefully selected when treating patients with parapharyngeal space tumours.
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Ahmad, Mukhtar Modibbo, Ibrahim Kayode Suleiman, Hector Oladapo Olasoji, et al. "Oral and Maxillofacial Tumours and Tumour Like Lesions: A 10 Years Review of Cases at the University of Maiduguri Teaching Hospital." Nigerian Journal of Medicine 33, no. 4 (2024): 240–44. https://doi.org/10.4103/njm.njm_103_24.
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Abstract Background: Oral and maxillofacial swellings are relatively common, very diverse and complex. They can be found in the maxilla, mandible and related soft tissues and facial skin. We audit cases of tumour and tumour-like lesions over 10 years period at the tertiary health facility, to provide baseline data and for comparison with other studies. Materials and Methods: This was a retrospective study conducted using a 10-year patient’s record that presented to our facility with tumour and tumour-like lesions. The information retrieved comprises demographics, location of the lesion, histopathological diagnosis and tumour type. Data were analysed using the Statistical Package for the Social Science (SPSS version 23; IBM SPSS 23 Chicago, Illinois, USA). Results: A total of 333 patients were reviewed, mean age of 31.57 years and Female: male (1.25:1). Benign lesions accounted for 262 (78.7%) of cases with a mean age of 28.34. Mandible was the most common site affected (38.1%), and ameloblastoma was the most common benign tumour in 56 (16.8%) of the cases. Fibrous dysplasia and ossifying fibroma are the most common benign non-odontogenic tumours (19 cases) each. Pleomorphic adenoma and mucoepidermoid carcinoma are the most common benign and malignant salivary gland tumours, respectively. Dentigerous cyst was the most common cystic lesion, whereas squamous cell carcinoma was the most common malignant tumour and the second-most common tumour in this study. Conclusion: This study confirmed findings from most previous studies. However, contrarily, a female preponderance was observed in this study, and the high prevalence of malignant tumours recorded, calls for extensive awareness and preventive measures campaigns at the community and legislative level.
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Scheele, Christian, Andreas Toepfer, Simone Beischl, et al. "Insights into the Distribution Patterns of Foot and Ankle Tumours: Update on the Perspective of a University Tumour Institute." Journal of Clinical Medicine 13, no. 2 (2024): 350. http://dx.doi.org/10.3390/jcm13020350.
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The rarity of foot and ankle tumours, together with the numerous histological entities, presents a challenge in accumulating sufficient patients to draw reliable conclusions. Therefore, we decided to present an update of a retrospective analysis of their distribution patterns, comprising 536 cases of foot and ankle tumours presented to our tumour board between June 1997 and June 2023. Our aim was to provide a comprehensive overview of the prevalence and distribution patterns of benign and malignant bone and soft tissue tumours of the foot and ankle. A total of 277 tumours involved bone (51.7%). Of these, 242 (87.4%) were benign and 35 (12.6%) were malignant. In addition, 259 soft tissue tumours (48.3%) were found, of which 191 (73.7%) were benign and 68 (26.3%) were malignant. The most common benign bone tumours were simple bone cysts, enchondromas, osteochondromas, aneurysmal bone cysts, and lipomas of bone. Common benign soft tissue tumours included a tenosynovial giant cell tumour, haemangioma, plantar fibromatosis, schwannoma, and lipoma. The most common malignant soft tissue tumours were synovial sarcoma, malignant melanoma, and myxofibrosarcoma. In terms of anatomical location, the hindfoot was the most common site (28.7%), followed by the midfoot (25.9%), ankle (25.4%), and forefoot (20.0%). The distribution of benign entities often follows typical patterns, which may facilitate an early diagnosis even without biopsy (e.g., simple bone cyst, plantar fibromatosis). On the other hand, the distribution patterns of many rare or malignant entities are inconsistent. Individual soft tissue malignancies occur very sporadically, even over long periods of time and in specialized tumour centres. It is therefore important to recognise that any suspicious mass in the foot and ankle must be considered a possible malignancy until proven otherwise.
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Ayogu, Benjamin O., Okwudili C. Amu, Okezie M. Mbadiwe, et al. "Management of Metastatic Paratesticular Tumour in a Resource-Poor Setting." Nigerian Journal of Medicine 32, no. 3 (2023): 333–37. http://dx.doi.org/10.4103/njm.njm_64_23.
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Abstract Paratesticular tumours are tumours that arise from the testicular tunics, spermatic cord, epididymis, or vestigial remnants. The tumours are rare and account for approximately 5% of intrascrotal neoplasms. About 75% of these tumours arise from the spermatic cord. Paratesticular tumours most commonly manifest as painless scrotal masses. Alternatively, the tumour may be incidentally noticed when a scrotal ultrasound scan is done for another intrascrotal pathology such as hydrocele, inguinoscrotal hernia, epididymo-orchitis, or suspected testicular tumour. We present a case of metastatic paratesticular tumour in a 21-year-old Nigerian male, who presented at the University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, in September 2018 at the age of 19 years with a painless right hemiscrotal mass. The patient was clinically evaluated with scrotal ultrasonography, testicular tumour markers, and liver function test. Biopsy specimen obtained was ignorantly discarded by the patient who was subsequently lost to follow-up. Histologic diagnosis of mesenchymal tumour (myxoid liposarcoma) was made two years after his initial presentation when he developed both inguinal and retroperitoneal lymph node metastasis at the age of 21 years. He was evaluated as clinical stage IV disease and then commenced on chemotherapy after baseline investigations. Our objective of presenting this report is to highlight the effect of delayed diagnosis in the management outcome, challenges in the provision of resources in low- and middle-income countries, and to emphasise the rarity of the tumour in our subregion.
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Ogbu, Christian Chika, Okezie Chinedu Ugwa, and Darlington Chidi Amadi. "Pattern and Epidemiologic Characteristics of Malignant Tumours Seen in Rivers State University Teaching Hospital, Port Harcourt: A Retrospective Study from January 2017 to December 2022." Journal of Cancer and Tumor International 15, no. 1 (2025): 93–98. https://doi.org/10.9734/jcti/2025/v15i1286.
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Aim: To review malignant tumours seen at Rivers State University Teaching Hospital from January 2017 to December 2022, to assess the gender and age distribution of these tumours and to assess whether there is a correlation between ages of these patients and these malignant tumours. Place and Duration: Department of Anatomical Pathology, River State University Teaching Hospital, Port Harcourt, Nigeria. A retrospective study from January 2017 to December 2022. Methodology: Four hundred and ninetyeight (498) cases were retrieved from the archives of the hospital cancer registry; 19 cases were excluded due to incomplete data. Data were entered into excel spread sheet and analysed using Microsoft Excel (version 2019). Results: The mean age was 51.7 ±15.7 years, and the modal age was 51 years. Most of these patients were females (71%). The commonest tumour in females was breast whereas the commonest tumour in males was prostate. There was a correlation between these malignant tumours and age ((χ² =4.25; P = .05). Conclusion: Majority of the cancers seen in our institution were diagnosed in females in the age bracket 30-69 years and there is a correlation between age and these tumours.
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Odokuma, Emmanuel Igho. "Spectrum of Fibroblastic lesions in University of Benin Teaching Hospital; A twenty year retrospective study." International Journal of Forensic Medical Investigation 1, no. 1 (2015): 1. http://dx.doi.org/10.21816/ijfmi.v1i1.4.
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IntroductionFibrous tumours are have been shown to occur commonly though the actual incidence is unknown since the lesions are predominantly benign and patient presentation is usually based on cosmesis. The few malignant varieties are however of great importance in health management hence this study which was aimed at determining the pattern of fibroblastic lesion in UBTH.Materials and methodThis was a retrospective study involving all anatomical pathology consultations in UBTH over twenty year period (January 1990- December 2010). The study involved records of all consultants made within the period and selection of the fibroblastic lesion and subsequent categorization according to WHO standard selected diagnosis were reviewed to confirm previous result according to current protocol.ResultThe study revealed that fibroma’s were the most common lesions constituting 52% of the recorded fibrous tumours while fibro sarcomas were the next most common. Nodular fasciitis were the least common. The mean age of fibrous tumour was 40.44 years old. While benign fibrous tumour occurred in the mid adulthood, malignant lesions presented predominantly in the elderly. The percentage prevalence of fibroblastic tumours was 0.137%Similarly the extremities were the most common sites of presentation; most benign tumour occurred in the upper extremities unlike the malignant variety that was distributed mainly to the lower extremity.ConclusionFibrous tumours are relatively common predominantly benign neoplasms which are more common in males than females. These lesions occur mainly in middle to late age intervals and are distributed to the extremities in most cases.
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Munawar Ali Baloch, Ikramuddin Ujjan, and Mehnaz Munawar. "Demography and Histopathological presentations of oral and maxillo-facial region tumours in Jamshoro, Pakistan." JMMC 9, no. 2 (2019): 81–84. http://dx.doi.org/10.62118/jmmc.v9i2.89.
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Introduction: Oral and Pharyngeal cancers are the sixth most common cancer globally. In developing countries, the annual incidence of oral cancer is around 275,000 cases while 130,300 cases of pharyngeal cancers excluding naso-pharynx. Salivary glands tumors are rare accounting for less than 5 % of tumors of head and neck region. The annual incidence of these tumors is 0.05 to 2 cases per 100,000 populations. Majority (over two third quarters) of salivary gland tumors occurs in the parotid glands of which most of them (2/3rd) of them are benign in nature. While most common parotid gland’s benign tumor is Pleomorphic Adenoma.
 Objective: To assess the morphology and histopathological features of oral and maxillo-facial region tumours among the patients in Liaquat University Hospital, Jamshoro, Sindh.
 Methodology: A Cross-sectional study was conducted at Liaquat University Hospital, Jamshoro. Data was collected regarding socio-demographic features, anatomical location of tumours and relevant history of patients admitted at surgical, medical and ENT units of Liaquat University Hospital, Jamshoro from January 2016 to January 2018. Histopathological diagnostic record was collected from Research and Diagnostic Laboratory of Liaquat University Hospital, Jamshoro.
 Results: A total of 160 biopsies were collected from surgical, medical and ENT units of Liaquat University Hospital with maximum (43%) of biopsies were from ENT unit. Most (51%) tumours were benign and 37% were malignant in nature. These tumours of oral and maxillo-facial region were mostly (38%) located in parotid region. Histopathological findings of this study revealed that majority (51%) tumours were Pleomorphic adenoma while (20%) of malignant tumours were Mucoepidermoid Carcinoma.
 Conclusion: Based on findings of the study, we conclude that the most common anatomical location of oral and faciomaxillary tumours, in either gender, is parotid region. The majority of oral and faciomaxillary tumours were benign; frequently occurring benign tumour was pleomorphic adenoma while most frequent malignant tumour was Muco-epidermoid Carcinoma.
 
 Key Words: Faciomaxillary tumours, Salivary glands, Pleomorphic adenoma.
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Nasir, Ariffin, Fahisham Taib, Nor Rosidah Ibrahim, Abdul Rahman Izani Ghani, Suria Emilia Suhana Othman Tan, and Norsarwany Mohamad. "Immature Brain Teratoma of An Infant In A University Hospital: A Case Report." JULY ISSUE 18, no. 4 (2022): 218–20. http://dx.doi.org/10.47836//mjmhs18.4.29.
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Teratomatous tumours of the head are rather uncommon. We report a 3-month-old child who presented with acute signs of raised intracranial pressure, needing craniectomy and subtotal tumour removal. The patient was diagnosed as intracranial immature teratoma grade 3, from the pathological study and elevated alpha-fetoprotein (AFP). Managing brain teratoma posed a challenge to the managing team due to the location of the tumour, the unavailability of standardized chemotherapy protocol and the dilemma of commencing adjuvant chemotherapy in a very young infant. The tumour was partially removed due to its critical location. And chemotherapy was delayed until the patient achieved 7 months of age. After four rounds of chemotherapy, the patient remained in remission for more than three years follow up.
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Brtková, Jindra, Andreas Nidecker, Helena Zídková, and Gernot Jundt. "Tumours and Tumour - Like Lesions of Scapula." Acta Medica (Hradec Kralove, Czech Republic) 42, no. 3 (1999): 103–10. http://dx.doi.org/10.14712/18059694.2019.152.
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A retrospective study of 68 cases of tumours and tumour - like lesions related to the scapula, included in the registry of the Bone Tumour Reference Centre at the Institute of Pathology/University Clinics, Basle, has been carried out. Each case was evaluated for lesion entity, activity and location, age and sex of the patient, and, in 49 files with available radiographic documentation (mostly plain films), for radiologic appearance, with the aim to predict the histologic diagnosis or at least the correct dignity of the lesion. Statistically most frequent were cartilaginous tumours. More than 1/3 of all cases were osteochondromas, which demonstrated mostly a typical appearance. They were encountered predominantly in the first 3 decades in males and were located most often in the body of the scapula. 1/4 of all cases were chondrosarcomas, which were prevailing in the 4th-7th decades, but were occasionally found at a younger age too. Chondrosarcomas were located mainly at the lateral scapular margin over the inferior angle and in the acromion and coracoid process and their appearance ranged from typical to falsely benign. 1/3 of the cases represented a number of other benign and malignant histological entities.
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Olaofe, Olaejirinde O., Ademola I. Soremekun, and James O. Oladele. "Fibroepithelial tumours of the breast seen in a tertiary health centre in southwestern Nigeria." International Journal of Research in Medical Sciences 11, no. 8 (2023): 2789–95. http://dx.doi.org/10.18203/2320-6012.ijrms20232405.
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Background: Fibroepithelial tumours of the breast are mainly fibroadenoma and phyllodes tumour. Our objective was to describe the clinical and pathological features of benign fibroepithelial tumours and then compare our findings with reports from other parts of the world. Methods: We carried out a retrospective study of all benign fibroepithelial tumours diagnosed in the Department of Morbid Anatomy and Forensic Medicine of Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria from January 1, 2018 to December 31, 2022. Results: A total of 538 cases of fibroadenoma were seen during the study period. Only 486 cases met the inclusion criteria and were then subsequently studied. Right sided tumour mass is seen in 203 (41.8%) patients, left sided masses in 173 (35.6%) patients and bilateral masses in 96 (19.8%) patients. The age of the patients ranges from 11 to 75 years. The average duration of symptoms is 16 months. The maximum length of fibroadenoma nodule ranges from 0.9cm to 15cm. The number of nodules seen in a patient range from 1 to 15. There is no association between the size of a fibroadenoma, number of the masses or the duration of symptoms before removal of the mass, and the age of the patient. Nineteen cases of phyllodes tumour were seen during the study period. Conclusions: Our study shows that fibroadenoma is the most common fibroepithelial tumour of the breast. A sizeable proportion of patients have bilateral tumours. Phyllodes tumour is much less common.
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Ozor, Nnamdi Sergius, Ifeoma Florence Ezejiofor, Ogochukwu Ifeanyichukwu Ezejiofor, et al. "Malignant Skin Tumors seen in Nigeria Nnamdi Azikiwe University Teaching Hospital Nnewi: A 10-year Review (January 2008 to December 2017)." Clinical Dermatology Review 7, no. 4 (2023): 352–57. http://dx.doi.org/10.4103/cdr.cdr_59_22.
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Abstract Background: Skin malignancy rank among the most common malignancies involving both sexes. Basal cell carcinoma is reported as the commonest malignancy even though studies have implicated Squamous cell carcinoma as the commonest especially in the tropic regions of the world. Aims and Objectives: This study aims at determining the base line data, frequency and trends of malignant skin tumours in Nnewi, Nigeria. It also implores the use of World Health Organization (WHO) in classification of skin malignancy. Materials and Methods: This study reviewed all histologically diagnosed skin malignancies at Histopathology department of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria from 2008 to 2017 and classified them using 2021 World Health Organization (WHO) skin tumour book. Results: A total of 387 skin biopsies were received in the Histopathology department during the study period. Out of these, 110 cases were malignant skin lesions (28.4%) majority were benign lesions. Keratinocytic or epidermal tumours were the most common (n: 54 cases; 49.1%) with squamous cell carcinoma being the commonest in the group (n: 34; 30.9%) followed by mesenchymal or soft tissue neoplasm (n:31 cases; 28.1%), melanocytic tumours (19.1%), skin adnexal tumour (2.7%) and haematolymphoid tumour (0.9%). The head and neck region (n: 49; 44.5%) was the commonest site of occurence of cutaneous neoplasms followed by lower limb (n: 32; 29.1%), groin (n:10; 9.1%), upper limb and trunk with 6 cases each (5.5%) Four (4) cases of Albinos with skin malignancies were seen in this research with a frequency of 3.6%. Fifty nine cases (53.6%) out of 110 malignant skin tumour were seen in males, while 51 (46.4%) of them were females, therefore the male to female ratio was 1.2:1. The mean age of those with malignant skin tumours was 52.9 years. Patients above 60 years of age constituted 57.3% while those less than 30 years constituted 14.5 % of the total malignant skin tumours. Conclusion: The frequencies of different morphologic patterns of malignant skin tumours in our environment were different from those reported in western countries. However, it is similar to most studies done in the Midwestern Nigeria tertiary hospitals with squamous cell carcinoma being the commonest skin malignancy followed by kaposi sarcoma.
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Sheereen, Shazima, Mohnish Zulfikar Manva, Shamama Sheereen, Namrata N. Patil, Rawa K. Abdelrahim, and Mohammed Malik Afroz. "“Pleomorphic adenoma in salivary glands: Insights from a 100-patient analysis”." Journal of Oral and Maxillofacial Pathology 28, no. 1 (2024): 42–48. http://dx.doi.org/10.4103/jomfp.jomfp_452_23.
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Introduction: Pleomorphic adenoma (PA) is a benign epithelial tumour originating from the salivary gland, specifically the parotid gland. This study aims to comprehensively analyse the clinical and pathological features of PA by examining the characteristics of the tumour, including its histological structure and immunohistochemical profile. Materials and Methods: Over 8 years, beginning in October 2015 and ending in October 2023, an exhaustive retrospective study was conducted in the Department of Pathology, Kasturba Medical College, Mangalore, Manipal University, Karnataka, India. The research focused on 100 cases of pleomorphic adenoma and involved a meticulous examination of the clinical and pathological characteristics obtained by retrieving the pertinent files. Results: Out of all the primary tumours, the majority (n = 70) was found in the parotid gland, followed by PA that developed from the minor salivary glands of the palate (n = 07), the submandibular gland (n = 17), and the lacrimal gland (n = 04). Only two cases had a primary tumour located in the lips. Females were more susceptible to these tumours than males. The parotid gland tumours showed a distinct trend in laterality, with 73 cases observed on the right side. In 85%, the initial symptom of the condition was painless swelling. Conclusion: Salivary gland PA is typically a benign tumour. However, a subset of these tumours can exhibit a malignant phenotype. The preferred treatment is surgical excision with adequate margins.
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Costa, Marcelo Carrijo, Ana Letícia Daher Aprígio Silva, Thais Almeida Moreira, Lígia Fernandes Gundim, and Alessandra Aparecida Medeiros-Ronchi. "Prevalence and epidemiological and histopathological features of canine cutaneous mast cell tumours in Uberlândia, Brazil." Acta Veterinaria Brno 86, no. 2 (2017): 189–93. http://dx.doi.org/10.2754/avb201786020189.
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This study aimed to perform a retrospective survey of canine cutaneous mast cell tumours at the Veterinary Hospital of the Federal University of Uberl‰ndia, as well as to gather epidemiological data, such as breed, age, sex, and location. We also sought to histopathologically classify and characterize the mast cell tumours. Mast cell tumour was the most common neoplasm, accounting for 16.78% of skin neoplasms. In terms of the epidemiological data, the mast cell tumours did not show sexual predilection. Animals aged 9 to 12 years were the most affected (44.14%). The genitalia were the most frequent location (28.15%), and mongrel dogs showed the highest prevalence (30.43%), followed by boxers (22.61%). A total of 92 slides were classified; grade II was most frequently seen (61.96%). Statistically, injuries such as necrosis, oedema, and haemorrhage were not related with histological classification (P > 0.05). Finally, the mitotic index was related to tumour grade (P < 0.05), and can act as an instrument for histological classification of these tumours. Mast cell tumour is the most common neoplasm in dogs, with no sex predilection. Contrary to what was expected, oedema, necrosis and haemorrhage do not increase according to graduation and can be seen in all classifications. Mitotic index is the best indicator to classify these neoplasms.
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Fukuhara, Sotaro, Shintaro Kuroda, Tsuyoshi Kobayashi, et al. "Preoperative percutaneous or transvascular marking for curative resection of small liver tumours with potential for missing during hepatectomy: a study protocol for an open-label, single-arm phase II study." BMJ Open 13, no. 10 (2023): e075891. http://dx.doi.org/10.1136/bmjopen-2023-075891.
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IntroductionSmall liver tumours are difficult to identify during hepatectomy, which prevents curative tumour excision. Preoperative marking is a standard practice for small, deep-seated tumours in other solid organs; however, its effectiveness for liver tumours has not been validated. The objective of this study is to evaluate the effectiveness of preoperative markings for curative resection of small liver tumours.Methods and analysisThis is an open-label, single-arm, single-centre, phase II study. Patients with liver tumours of ≤15 mm requiring hepatectomy will be enrolled and will undergo preoperative marking by placing a microcoil near the tumour using either the percutaneous or transvascular approach. The tumours, including the indwelling markers, will be excised. The primary endpoint will be the successful resection rate of liver tumours, defined as achieving a surgical margin of ≥5 mm and ≤15 mm. Secondary endpoints will include the results of preoperative marking and hepatectomy.Ethics and disseminationEthical approval for this trial was obtained from the Ethical Committee for Clinical Research of Hiroshima University, Japan. The results will be published at an academic conference or by submitting a paper to a peer-reviewed journal.Trial registration numberjRCTs062220088.
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Gertrude Chioma, Okonkwo,, and Ogenyi, Samuel Ifedioranma. "Histological and Immuno-Histochemical Evaluation of Mast Cells in a Retrospective Cross – Sectional Study of Breast Tumour Patients." International Journal of Research and Innovation in Social Science VIII, no. XII (2025): 1674–83. https://doi.org/10.47772/ijriss.2024.8120143.
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Background: Breast tumours are the most important lesion of the female breast, the most common invasive cancer in women and second leading cause of cancer death in women after lung cancer. This is becoming most common and more deadly with over 200,000 cases per year in Nigeria and Africa in general. Methods: A retrospective cross-sectional study was carried out from 2017 to 2023. One hundred and fifty (150) archived breast tumour tissue samples were retrieved from the histopathology Laboratory of Madonna University Teaching, Hospital, Elele. Patients’ data were retrieved from the histopathology reports. Tissue blocks were re-embedded in fresh paraffin wax and 4µ thick serial sections were cut and stained accordingly. Results: Benign tumours showed increased number of mast cells and mast cell membrane permeability making it hyper-chromatic with hypertrophy specifically having the highest immune reactivity count. Malignant tumours had decreased number of mast cells surrounding the periphery of the tumour with lobular carcinoma specifically showing the lowest number of mast cell per high power field. Patients’ ages at presentation ranged from 15 to 64 and breast tumour was highest between the ages of 25 ≤34. Conclusion: The evaluation and mast cell expression pattern in breast tumours maintained different activities of mast cells in benign and malignant tumours and could serve as a positive prognostic indicator for patient’s stratification and specific treatment. However, further studies on immune-histochemical evaluation of mast cells in breast tumours should be extended to frozen sections.
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Honkanen, Tiia J., Milla E. K. Luukkainen, Antti Tikkanen, et al. "Immune cell profiles of metastatic HER2-positive breast cancer patients according to the sites of metastasis." Breast Cancer Research and Treatment 191, no. 2 (2021): 443–50. http://dx.doi.org/10.1007/s10549-021-06447-6.
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Abstract Purpose Recent works have characterized that metastatic site can affect the tumour immune profiles and efficiency of cancer immunotherapies. The prognosis of HER2-positive breast cancer is associated with the characteristics of the tumour immune microenvironment, with immunological cells playing a central role in efficiency of HER2-targeted antibodies. Here we investigated the prognostic significance of different metastatic sites and their correlation to tumour immune profiles in HER2-positive breast cancer treated with trastuzumab. Methods We collected all (n = 54) HER2-positive metastatic breast cancer patients treated with trastuzumab containing regimens at Oulu University Hospital 2009–2014. Pathological and clinical data were collected from electronic patient records. The tumour immune profiles were analysed from pre-treatment primary tumours using well-characterized immunological markers with computer-assisted immune cell counting. Results Of the metastatic sites, only liver metastases were associated with poor prognosis (hazard ratio 1.809, 95% confidence interval 1.004–3.262), especially when presented as the primary site of metastases. Of the other sites, pulmonary metastases characterized a patient profile with trend to improved survival. Of the studied tumour immunological markers, patients with liver metastases had low densities of CD3+ T cells (p = 0.030) and M1-like macrophages in their primary tumours (p = 0.025). Of the other studied markers and sites, patients with pulmonary metastases had low STAB1+-immunosuppressive macrophage density in their primary tumours. Conclusion Our results suggest that the site of metastasis is associated with prognosis in HER2-positive breast cancer, highlighted by the poor prognosis of liver metastases. Furthermore, liver metastases were associated with adverse tumour immune cell profiles.
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Rahat, Noshaba, and Humera Shahzad. "Frequency of Immunohistochemical Marker GPC-3 Expression in Malignant Tumors." Pakistan Journal of Medical and Health Sciences 17, no. 6 (2023): 202–4. http://dx.doi.org/10.53350/pjmhs2023176202.
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Objective: To determine the frequency of immunohistochemical marker GPC-3 expression in malignant tumours in a tertiary care hospital. Material & Methods: This cross sectional study was conducted at the department of Histopathology, Dr. Ziauddin Medical University and Hospital, north campus, Karachi, a total of 114 cases of malignant tumours were enrolled using consecutive sampling technique in a period of six months from 1st April, 2012 to 30th September, 2012. Patients of both genders and all age groups of histologically diagnosed case of hepatocellular carcinoma (HCC) metastatic tumours, germ cell tumours (GCT) and squamous Cell Carcinoma (SCC) were all included in the study. The patients with benign tumours, malignant lymphoma, brain tumours, breast tumours, colon carcinoma and malignant melanoma were excluded from the study. The study outcome was determined as frequency of positive GPC-3 expression. Results: A total of 114 cases were enrolled. Average age was 48.8 years with majority of cases (70.4%) were 40 years or above age. Male gender was slight dominance (53.5%). Squamous cell carcinoma was the most common (78.9%) followed by, germ cell tumours (10.5%) including (6.1%) yolk sac tumour and 4.3% Germinoma. Hepatocellular carcinoma was found in (6.1%) study cases. Most of the cases (45.6%) were moderately differentiated (SCC and HCC),followed by poorly (42.1%) and well differentiated (12.3%) grading. The frequency of positive GPC-3 expression was 25.4% in all malignant tumour in the current study. It is diagnostic and accuracy is more than other markers for definitive diagnosis and tp differenciate between primary and metastatic tumors. Conclusion: In conclusion out of 114 cases 25.4% of total cases show GCP-3 positively, among which GCT were 24.1% and HCC were 85.7% which is quite similar to other reported studies. Type of the tumour was found to be significantly associated with the age group above 40 years (P=0.000). There is significant association between type of tumour and GCP-3 expression (P=0.000). Keywords: Malignant Tumours, SCC, HCC GCT, GPC, GPC-3 expression
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Wierzbicka, Małgorzata, Ewelina Bartkowiak, Wioleta Pietruszewska, et al. "Rationale for Increasing Oncological Vigilance in Relation to Clinical Findings in Accessory Parotid Gland—Observations Based on 2192 Cases of the Polish Salivary Network Database." Cancers 16, no. 2 (2024): 463. http://dx.doi.org/10.3390/cancers16020463.
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The accessory parotid gland (APG, Vth level) differs in histological structure from main parotid tissue. This gives rise to the hypothesis, mirrored in clinical observations, that the representation of tumours is different than in the rest of the gland. The aim of the study was to analyse the epidemiological and histological differences of parotid tumours located in regions I–V, with particular emphasis on the distinctiveness of region V. To define the epidemiological factors that will indicate the risk of histological malignancy from clinically benign appearance, multicentre prospective studies conducted between 2017–2021 by five Head and Neck Surgery University Departments, cooperating within the Polish Salivary Network Database 1929 patients (1048 women and 881 men), were included. The age, gender, patient occupation, place of inhabitation, tumour size, clinical features of malignancy, histology, and facial nerve (FN) paresis were analysed for superficial (I_II) and deep (III_IV) lobes and with special regard to the tumours affecting region V. Twenty eight tumours were located exclusively in region V (1.45% total) and seventy-two tumours were found in region V exhibiting extensions to neighbouring regions (3.7% total), characterised as significantly younger and less frequent in retirees. In I–IV regions, approximately 90% of tumours were benign, with pleomorphic adenoma (PA) and Whartin tumour (WT) predominance. In region V, PA exceeded 75% but WT were casuistic (2/28). Incidences of malignancies in region V was 40% but clinical signs of malignancy were evident only in tumours > 4 cm or in the presence of FN paresis. In 19% of patients with a benign appearance, imaging revealed malignancy; however, 38% of patients showed false negative results both in terms of clinical and radiological features of malignancy. Logistic regression models in 28 patients with tumours located exclusively in region V vs. 1901 other patients and in 100 patients with V extension vs. 1829 other patients showed no clinical symptoms of malignancy binding with final malignant tumour histology as a single variable or in combination with other variables. The logistic regression models obtained in this study show strong linkage between tumour location and predictors (age, male gender, and tumour diameter) and also aimed to function as a good classifier. Our conclusion is that, despite the very clear image of the mid-cheek tumour which is easily accessible in palpation and ultrasound examination, it is necessary to improve oncological vigilance and preoperative patient preparation.
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Youssef, T. F., A. Matter, and M. R. Ahmed. "Surgical management of vestibular schwannoma: attempted preservation of hearing and facial function." Journal of Laryngology & Otology 127, no. 5 (2013): 473–78. http://dx.doi.org/10.1017/s0022215113000546.
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AbstractBackground:Vestibular schwannomas are benign tumours which usually originate from the vestibular portion of the VIIIth cranial nerve. Treatment options include observation with serial imaging, stereotactic radiation and microsurgical removal.Aim:The goal of surgery was complete eradication of tumour with preservation of hearing and facial nerve function.Methods:A retrospective review was undertaken of 24 cases of vestibular schwannoma jointly operated upon by a team of neurosurgeons and otologists at the Suez Canal University Hospital, with assessment of VIIth and VIIIth cranial nerve function, tumour size, and extent of growth. All surgery utilised a retromastoid, suboccipital approach.Results:Complete tumour removal was achieved in 19 patients. Anatomical preservation of the facial nerve was possible in 66.6 per cent of patients. Pre-operative, useful hearing was present in four patients, and preserved in 80 per cent. Cerebrospinal fluid leakage was diagnosed in two (8.3 per cent) patients, who responded to conservative therapy.Conclusion:The retromastoid, suboccipital surgical approach to the skull base can be safely and successfully achieved using a microsurgical technique, with minimal or no damage to neurovascular structures, even for large tumours.
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Tanaka, Toshihide. "Investigation of the effect and prediction factors of bevacizumab on immunoregulation in glioblastoma." Impact 2023, no. 3 (2023): 21–23. http://dx.doi.org/10.21820/23987073.2023.3.21.
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Glioblastoma (GB) is one of the most common and malignant tumours that originates in the brain. It has a high likelihood of recurrence and a poor survival rate. Professor Toshihide Tanaka, Chief Medical Officer, Jikei University School of Medicine, conducts translational research based on clinical samples of glioblastoma tumours obtained from brain tumour surgery procedures as well as animal studies. He heads up a multidisciplinary team focused on the design and selection of personalised treatments for hypervascular malignant gliomas. In their current project, the researchers are investigating the use of Bevacizumab (Bev), a monoclonal antibody that targets vascular endothelial growth factor (VEGF). VEGF enhances tumour growth by changing the surrounding environment to one more favourable for tumour growth. The effect of Bev on cancers is transient and the mechanisms of resistance to Bev are yet to be investigated in detail. The researchers are therefore seeking to discover predictive biomarkers of microenvironment-targeted therapy for GB. In order to investigate the effect and prediction factors of Bev on immunoregulation in GB, Tanaka and the team perform in situ observations using histological techniques including immunohistochemistry using tumour tissues from patients who have undergone surgical resection. The researchers have been able to demonstrate a decrease in microvascular density and an improvement in the tumour microenvironment after treatment with Bev.
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Tanaka, Toshihide. "Investigation of the effect and prediction factors of bevacizumab on immunoregulation in glioblastoma." Impact 2023, no. 2 (2023): 53–55. http://dx.doi.org/10.21820/23987073.2023.2.53.
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Glioblastoma (GB) is one of the most common and malignant tumours that originates in the brain. It has a high likelihood of recurrence and a poor survival rate. Professor Toshihide Tanaka, Chief Medical Officer, Jikei University School of Medicine, conducts translational research based on clinical samples of glioblastoma tumours obtained from brain tumour surgery procedures as well as animal studies. He heads up a multidisciplinary team focused on the design and selection of personalised treatments for hypervascular malignant gliomas. In their current project, the researchers are investigating the use of Bevacizumab (Bev), a monoclonal antibody that targets vascular endothelial growth factor (VEGF). VEGF enhances tumour growth by changing the surrounding environment to one more favourable for tumour growth. The effect of Bev on cancers is transient and the mechanisms of resistance to Bev are yet to be investigated in detail. The researchers are therefore seeking to discover predictive biomarkers of microenvironment-targeted therapy for GB. In order to investigate the effect and prediction factors of Bev on immunoregulation in GB, Tanaka and the team perform in situ observations using histological techniques including immunohistochemistry using tumour tissues from patients who have undergone surgical resection. The researchers have been able to demonstrate a decrease in microvascular density and an improvement in the tumour microenvironment after treatment with Bev.
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Tamrakar, Suman Raj, Ramesh Makaju, Abha Shrestha, and Suresh Kayastha. "Comprehensive study of ovarian tumours in Kathmandu University Hospital." Journal of Kathmandu Medical College 7, no. 4 (2018): 173–79. http://dx.doi.org/10.3126/jkmc.v7i4.23322.
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Background: Ovarian tumours account for 15% to 25% of all primary malignancy and the leading cause of death from gynaecolgical malignancies. There are limited publications related to ovarian tumours from Nepal. Ovarian related surgeries are the common surgeries in Kathmandu University Hospital. This study aims to provide basic information related to ovarian tumours from this geographical region of Nepal.
 Objectives: To review the nature of ovarian problems and certain socio-demographic information namely: caste, age, address and co-morbid condition of the patients presenting with ovarian problems.
 Methodology: This is a retrospective study of patients seeking surgical treatment of ovarian lesions in Kathmandu University Hospital from January 1, 2011 to June 30, 2018. This study was undertaken by reviewing the inpatient, outpatients and OT records in the Department of Obstetrics and Gynaecology and the records from Department of Pathology. All the files and computer records were reviewed and analyzed for nature of ovarian problems and certain demographic variables.
 Results: Out of the 860 cases, about 61% were non-neoplastic while benign ovarian tumours and malignant ovarian tumours were 35% and 3.7 % respectively. Almost one third of the cases were of Brahmin/Chhetri (37.3%) and 58.3% of the patients were from Kavre district. Mean age of the patients with ovarian problems was 34.89±11.15 years (range 12-72 years). There was no statistically significant difference between the mean age of patients with non-neoplastic ovarian lesions and neoplastic ovarian lesions (p value = 0.3371). There was statistically significant difference between the mean age of patients with benign ovarian tumours and malignant ovarian tumours (p value = 0.0001). And malignant ovarian tumours were significantly high among patients above 41 years in comparison to benign ovarian tumours of same age group (p value = 0.0008). Out of 32, ten malignant ovarian tumours occurred in relatively young age group. Of the 860 ovarian lesions, 438 and 422 ovarian lesions were removed through open technique and laparoscopic techniques respectively. Mature cystic teratoma (64.1%) was the commonest benign tumor and serous cyst adenocarcinoma (43.8%) was the commonest malignant tumour in this study.
 Conclusion: Ovarian tumours are one of the gynaecological diagnoses in Kathmandu University Hospital. If only ovarian neoplasms are considered, most of the ovarian tumours are benign and few are malignant. Minimal invasive surgeries are possible, except that for malignant ovarian tumours.
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Kaul, Neelaksh, Sweta ..., and Uma Sharma. "Histomorphological Spectrum of Ovarian Lesions at a Rural Care Hospital in Gurugram." Indian Journal of Medical and Health Sciences 7, no. 1 (2020): 21–27. http://dx.doi.org/10.21088/ijmhs.2347.9981.7120.4.
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Background: The ovaries are paired intrapelvic organs of female reproductive system. It is unique in the variety of lesions that can arise from ovary as it is complex in its embryology, histology and steroidogenesis. The ovary consists of totipotent sex cord cells and multipotent mesenchymal cells. They are common site of non-neoplastic and neoplastic lesions. Some non-neoplastic lesions of the ovary usually present as a pelvic mass and mimic an ovarian neoplasm and thus posses a great challenge to gynecological oncologist and pathologist. Therefore their proper recognition and classification is important for appropriate therapy. Material and Methods: A prospective clinicopathological study of 58 cases of non-neoplastic and neoplastic lesions of ovary was conducted in Department of Pathology, FMHS, SGT University, Gurugram over the period of one years from June 2018 to June 2019. The materials for this study were oopherectomy specimen, ovarian cystectomies as well as hysterectomy with unilateral/bilateral salphingoopherectomy received from department of Obstetrics and Gynecology. The non-neoplastic and neoplastic lesions from representative sections were studied and classified according to World Health Organisation (WHO) and correlation of histopathological patterns with age, bilaterality, morphology and grading of the tumour was done. Results: A total of 58 cases were studied out of which 31 (53.45%) cases were non-neoplastic and 27 (46.55%) cases were neoplastic. Among the 31 nonneoplastic cases, the most common lesion found was simple cyst with 13 (41.94%) cases followed by corpus luteal cyst with 6 (19.35%) cases. Among the 27 neoplastic ovarian lesions, 17 (62.96%) cases were benign tumour, 2 (7.4%) cases were borderline tumour and 8 (29.64%) cases were malignant tumour. These tumours were classified according to WHO classification and categorised in three main groups. Surface epithelial tumours constituted the majority with 17 (62.98%) cases, followed by germ cell tumours which constituted 8 (29.62%) cases and sex cord stromal tumours constituted 2 (7.4%) cases. Conclusion: Ovarian cancers are called as “silent killer” as in most of the primary ovarian tumour they remain asymptomatic until the advanced stage. However, histomorphological study of tumour is still the gold standard method, these observations and results proved to be valuable base line information regarding frequency and pattern of ovarian tumours.
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V. KASHAMA, G. OVIEBO ANDO, S. BOURAMDANE, K. ELMKADDEM, H. HBIBI, and S. BENMILOUD. "Hepatoblastoma: Experience of the paediatric haematology and oncology department, Hassan II university hospital of Fez." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 185–89. http://dx.doi.org/10.30574/wjarr.2024.22.2.1363.
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Introduction: Hepatoblastoma is the most common malignant hepatic tumour in children. However, it is a rare disease, representing approximately 2% of childhood tumours. The treatment combines chemotherapy with surgical excision. The objective of this study was to describe the epidemiological, clinical, therapeutic and progressive aspects of hepatoblastoma treated in the paediatric haematology and oncology department at the University Hospital Hassan II of Fès. Patients and Methods: This was a descriptive and retrospective study conducted over a 11-year period. All patients aged 0 to 15 years who were admitted and treated for hepatoblastoma were included. Results: 24 patients met the study criteria, including 9 boys and 15 girls. The average age at diagnosis was 11.52 months ± 4.9. The most common reason for consultation was abdominal distension. Hepatomegaly was observed in 50% of cases. The average tumour size was 116 mm. At the time of diagnosis, one-third of patients had pulmonary metastases, and all patients were classified as high risk. Therapeutically, 19 patients (79.17%) received chemotherapy and 16 (66.67%) underwent surgery. On the evolutionary level, we observed a recovery without events in 10 (41.67%) patients. Conclusion: hepatoblastoma is a rare tumour, but remains the most common hepatic tumour in children. Despite progress in diagnostic and therapeutic means, the mortality rate is significant.
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Karim, MI, SM Ali, S. Akhter, SMJ Islam, MM Karim, and MR Alam. "A Study on Histomorphological Spectrum of Childhood Malignant Tumour: Evaluation of 60 Cases at Different Center in Dhaka City." Journal of Armed Forces Medical College, Bangladesh 9, no. 1 (2014): 57–62. http://dx.doi.org/10.3329/jafmc.v9i1.18727.
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Introduction: About 2% of all malignant tumours occur in infancy and childhood. Malignancy is the second common cause of childhood death in developed world, accounting for 10 - 12.3% of all childhood deaths. Eighty eight percent of worlds children live in developing countries, where access to adequate care is limited. Incidence of childhood cancer is increasing in this region gradually. Objectives: The objective of this study was to find out the histomorphological pattern of childhood cancers in our country and assess the trends of malignancies in different age group. Methods: This prospective study was carried out from January 2008 to January 2012. During this period data was analyzed for the malignancies occurring in the age group 0-14 years. Data was categorized according to incidence of paediatric malignancies in different age groups, sex and types of tumours. All the children below 15 years with confirmed diagnosis of cancer by means of histopathological examinations were included in this study. Results: Total 3120 patients were diagnosed as having malignancies at Armed Forces Institute of Pathology (AFIP), Delta Hospital Ltd & Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka, out of which 60 cases were paediatric malignant tumours. Overall incidence of paediatric tumour was 1.92%. Out of which 26 cases (43.33%) were female and 34 (56.66%) cases male. The male - female ratio was 1.3:1. Males were more affected than females. The peak incidence of paediatric tumors (37%) was found in children between the age group 10 to 14 yrs. The pattern of childhood tumours shows wide variation among the age groups. In this study, at 0-4 yrs age group small round cell tumours (Neuroblastoma, Retinoblastoma), 5-9 yrs germ cell tumour, 10-14 yrs bone tumour (Ewing sarcoma, Osteosarcoma) were the commonest tumour. Conclusion: We conclude that there are certain notable differences between tumours of our study and those reported from other parts of the world. In our study small round cell tumor is most frequent childhood tumour. DOI: http://dx.doi.org/10.3329/jafmc.v9i1.18727 Journal of Armed Forces Medical College Bangladesh Vol.9(1) 2013: 57-62
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NIAZI, S., M. ARSHAD, and M. MUNEER. "A Histopathological Audit of Thyroid Surgical Specimens." Annals of King Edward Medical University 13, no. 1 (2021): 51–56. https://doi.org/10.21649/akemu.v13i1.4659.
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Objective: This study was conducted to see the frequency of different morphological lesions encountered in surgically excised thyroid glands. Study design: Descriptive cross sectional study. Place and duration of study: The study was conducted at the Department of Pathology, King Edward Medical University, Lahore during a 2-year period commencing from 1st January 2005 to 31st December 2006. Materials & methods: All thyroid surgical specimens referred from the four major Surgical Units of Mayo Hospital, Lahore, to the Department of Pathology, King Edward Medical University, Lahore, during a 2-year period (2005-2006). Specimens from both sexes and all age groups were included in this study. Results: A total of 662 thyroid specimens were examined histologically. They constituted of 588 specimens (88.82%) from females and 74 specimens (11.17%) from males. The commonest lesion was Colloid Goiter (diffuse and multinodular) constituting 434 cases (65.55%). Next in frequency were tumours (benign and malignant) constituting 151 cases (22.80%). Benign tumours comprised of 113 cases (74.83%) and malignant constituted 38 cases (25.16%) out of 151 thyroid tumours. Follicular adenoma was the commonest tumour constituting of 108 cases (71.52%) followed by Papillary carcinoma constituting 27 cases (17.88%). Other non-neoplastic thyroid lesions included diffuse hyperplasia (3.62%), thyroiditis 2.26%), hyperplastic nodules (1.35%), colloid nodules (1.20%), completion thyroidectomy specimens (1.05%), colloid cysts (0.90%), colloid goiters with associated hyperplastic changes (0.60%), goiters with thyroiditis (0.45%) and a single case of dyshormonogenetic goiter (0.15%). Conclusions: Colloid goiter is the commonest- lesion of the thyroid gland in both sexes and is the commonest cause of an enlarged thyroid gland. This is followed by Follicular adenoma which is the commonest benign tumour of the thyroid. Papillary carcinoma is the commonest malignant tumour seen in all age groups with a predominance in females.
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Basnet, Dipika, Ramesh Makaju, Rachana Dhakal, et al. "Histopathological Spectrum of Skin Neoplasm in a Tertiary care center." Journal of College of Medical Sciences-Nepal 20, no. 4 (2021): 368–73. https://doi.org/10.3126/jcmsn.v20i4.63498.
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ABSTRACT Background Skin is the largest organ in the body. An extensive range of disease can develop from various compartment of skin. Early diagnosis can help in prognosis and planning an effective management. Hence, differentiation of malignant and benign nature of the lesion is vitally important which can be achieved by histopathological examination. The objective of this study was to analyze the histomorphological spectrum of skin neoplasm received in a tertiary center. Methods This is a retrospective study done from January 2018 to December 2021 in the Department of Pathology, Dhulikhel Hospital - Kathmandu University Hospital (DH - KUH). Relevant clinical data of the patients were obtained from the histopathological records of the patient from the pathology department. Results A total of 248 cases of skin tumours were studied, out of which 194(78.2%) cases were benign and 54(21.8%) cases were malignant. The incidence of keratinocytic tumours was highest consisting of 107(43.2%) cases followed by soft tissue tumour, melanocytic tumours appendegeal tumours and hematoplymphoid tumours. Most common benign tumour was fibroepithelial polyp and malignant neoplasm was squamous cell carcinoma. The age of patient ranged from 4 to 94 years. Benign tumours were most prevalent in age group of 31-40 years and malignant neoplasm in 61-70 years. Head and neck region was the commonest site for occurrence of the skin neoplasms. Conclusions Skin tumours comprise of wide spectrum of benign and malignant lesions. Histopathological study of the skin biopsies is required for definite diagnosis and treatment.
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V., KASHAMA, OVIEBO ANDO G., BOURAMDANE S., ELMKADDEM K., HBIBI H., and BENMILOUD S. "Hepatoblastoma: Experience of the paediatric haematology and oncology department, Hassan II university hospital of Fez." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 185–89. https://doi.org/10.5281/zenodo.14550455.
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<strong>Introduction</strong>: Hepatoblastoma is the most common malignant hepatic tumour in children. However, it is a rare disease, representing approximately 2% of childhood tumours. The treatment combines chemotherapy with surgical excision. The objective of this study was to describe the epidemiological, clinical, therapeutic and progressive aspects of hepatoblastoma treated in the paediatric haematology and oncology department at the University Hospital Hassan II of Fès. <strong>Patients and Methods:</strong> This was a descriptive and retrospective study conducted over a 11-year period. All patients aged 0 to 15 years who were admitted and treated for hepatoblastoma were included. <strong>Results</strong>: 24 patients met the study criteria, including 9 boys and 15 girls. The average age at diagnosis was 11.52 months ± 4.9. The most common reason for consultation was abdominal distension. Hepatomegaly was observed in 50% of cases. The average tumour size was 116 mm. At the time of diagnosis, one-third of patients had pulmonary metastases, and all patients were classified as high risk. Therapeutically, 19 patients (79.17%) received chemotherapy and 16 (66.67%) underwent surgery. On the evolutionary level, we observed a recovery without events in 10 (41.67%) patients. <strong>Conclusion</strong>: hepatoblastoma is a rare tumour, but remains the most common hepatic tumour in children. Despite progress in diagnostic and therapeutic means, the mortality rate is significant.
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Ng, ES, A. Saw, S. Sengupta, AR Nazarina, and M. Path. "Giant Cell Tumour of Bone with Late Presentation: Review of Treatment and Outcome." Journal of Orthopaedic Surgery 10, no. 2 (2002): 120–28. http://dx.doi.org/10.1177/230949900201000204.
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Purpose. To review cases of giant cell tumour of bone or osteoclastoma managed at the University Malaya Medical Center, University of Malaya, Kuala Lumpur, from January 1990 to December 1999. Methods. Medical records of all patients with musculoskeletal tumours were reviewed. Demographic data, clinical presentation, surgical management, and clinical outcomes were reviewed retrospectively. Results. Most of the 31 patients who were treated for giant cell tumour of bone presented late on the basis of the duration of their symptoms and radiological features. Five of the patients had been referred for local recurrences. 26 patients were treated for primary tumours: 18 needed wide excision, 7 curettage, and one amputation. The joint could not be preserved and arthrodesis was performed for 11 patients. Three (12%) of the 26 patients had local recurrence during a mean follow-up of 60 months, including one (6%) who had recurrence after wide excision and 2 (29%) after curettage. Pulmonary metastasis was noted in 4 cases, 2 of which were confirmed histologically. Conclusion. Even in an advanced stage of disease, good clinical outcomes can be achieved with adequate excision and appropriate reconstruction. For lesions around the knee, autologous rotational grafting is a good alternative method of reconstruction.
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Van Laethem, Delphine, Alex Michotte, Wilfried Cools, et al. "Hyperprolactinemia in Acromegaly is Related to Prolactin Secretion by Somatolactotroph Tumours." Hormone and Metabolic Research 52, no. 09 (2020): 647–53. http://dx.doi.org/10.1055/a-1207-1132.
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AbstractThe aim of this study is to assess differences in patient characteristics, tumour characteristics and hormone levels between acromegalic patients with and without hyperprolactinemia. 44 patients of the University Hospital of Brussels, Belgium with acromegaly who were diagnosed between January 2007 and July 2018 were included in this study. Nineteen patients were classified in the hyperprolactinemia group and 25 patients were classified in the normoprolactinemia group. No significant differences between acromegalic patients with and without hyperprolactinemia were found in age at diagnosis, gender, presence of hyperprolactinemia symptoms, insulin-like growth factor 1, growth hormone and testosterone levels, tumour volume, tumour invasiveness, immunohistochemistry of growth hormone and prolactin, Ki-67 index and mitotic index. However, for a cut-off of 10% of prolactin-positive cells, there was a trend towards a higher percentage of prolactin-positive tumours in hyperprolactinemia patients (p=0.054) and higher mean prolactin level in case of positive prolactin immunostaining (p=0.007)). In our study there were no differences in characteristics between acromegaly patients with hyper- and normoprolactinemia. An association between the serum prolactin level and the positivity of prolactin immunohistochemistry of the adenoma tissue was found. The absence of a difference in tumour volume between patients with hyper- and normoprolactinemia suggests that the hyperprolactinemia is likely to be caused by the co-secretion of growth hormone and prolactin by the tumour. Finally, for the first time, the cut-off of 10% of prolactin cells was validated for the diagnosis of somatolactotroph tumours in acromegaly.