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Journal articles on the topic 'Tumor germinativo'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Zukin, Mauro, João Francisco S. Alonso, Mário Alberto Dantas L. da Costa, and Maria Luisa M. Silva. "Tumor germinativo extra-gonadal e síndrome de Klinefelter - Relato de caso." Revista Brasileira de Cancerologia 42, no. 4 (2022): 235–39. http://dx.doi.org/10.32635/2176-9745.rbc.1996v42n4.2904.

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Muitos relatos vêm sugerindo a associação entre a síndrome de Klinefelter e o tumor germinativo. Um risco elevado de tumor germinativo extragonadal (mediastinal) ocorre a partir da adolescência até 30 anos. O autor apresenta ocaso de um jovem de 19 anos de idade com sintomas respiratórios, massa torácica e características clínicas de síndrome de Klinefelter. O cariótipo do sangue periférico foi de 47 XXY e o estudo da lesão torácica foi de teratoma imaturo O paciente foi tratado com quimioterapia combinada seguida de toracotomia, estando em remissão completa há seis anos após o diagnóstico. Es

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2

Amar, Ali, Marilene Paladino Rosa, Abrão Rapoport, Marcos Ribeiro Magalhães, and Marcos Brasilino de Carvalho. "Reatividade linfonodal com metástase cervical de tumor primário oculto: estudo de 24 pacientes." Revista do Colégio Brasileiro de Cirurgiões 28, no. 3 (2001): 193–97. http://dx.doi.org/10.1590/s0100-69912001000300007.

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OBJETIVO: Avaliar a reatividade linfonodal em pacientes com metástase cervical de tumor primário oculto. MÉTODO: Foram avaliados retrospectivamente 24 pacientes submetidos a esvaziamento cervical entre 1983 e 1995 devido à metástase de tumor primário oculto. Os cortes histológicos dos 601 linfonodos resultantes foram corados pela hematoxilina-eosina e avaliados à microscopia óptica. A reatividade linfonodal considerou a presença de hiperplasia paracortical, hiperplasia de centro germinativo e hiperplasia sinusal. Foram avaliadas a relação da reatividade linfonodal, ruptura capsular, necrose e

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3

Lima, Kledoaldo Oliveira de, Lukas Almeida Oliveira dos Santos, Romero Henrique Simões de Melo Barbosa, Arthur Lira de Melo, Alexsandro Pedro da Silva, and Madi Veiga Diniz. "Megakaryoblastic Acute Myeloid Leukemia Associated with a Testicular Tumour in a Young Adult: a Case Report." Journal of Health Sciences 26, no. 1 (2024): 57–59. http://dx.doi.org/10.17921/2447-8938.2024v26n1p57-59.

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Abstract Acute megakaryoblastic leukemia (M7 AML) is a rare subtype of acute myeloid leukemia in adults, the incidence of which is higher in children aged 1 to 3 years, especially in patients with Down Syndrome; and in the age group between 60 and 70 years old, with an adverse prognosis. We report the case of a 28-year-old male patient, with a history of non-seminoma germ cell tumour of the testis, diagnosed with M7 AML. Nine months after performing an orchiectomy to remove the testicular tumour, the patient developed dyspnea, dry cough and asthenia, associated with the presence of erythematou

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4

Rabinowits, Milton, and Carlos Augusto V. de Andrade. "BED: Uma Combinação com Etoposide, Bleomicina e Cisplatinum Efetiva em Tumores Germinativos Não-Seminomatosos Disseminados de Testículo." Revista Brasileira de Cancerologia 33, no. 4 (2023): 341–46. http://dx.doi.org/10.32635/2176-9745.rbc.1987v33n4.3222.

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Um total de 21 pacientes (pts) com tumor germinativo não-seminomatoso disseminado de testículo foram tratados no período de outubro de 1981 a outubro de 1985, com uma combinação quimioterápica (BED), em que o etoposide (VP16)substituíaa vinblastina (VLB), combinado com bleomicina (BLM) e cisplatinum (DDP), com a finalidade de diminuir a toxicidade e obter melhores resultados. Remissão completa (RC) foi obtida em 15 (71%), e dos seis restantes não foi encontrado tumor viável em quatro, totalizando 19 (90%) de resposta favorável (RF); 14 (67%) permanecem vivos sem doença (SD) após 12 a 48 meses

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5

Lombardi, Welington, Cibele Repele Duch, Luciana Borges Lombardi, et al. "Linfoma Primário de Mama: um raro relato de caso." Brazilian Journal of Health Review 6, no. 3 (2023): 8767–75. http://dx.doi.org/10.34119/bjhrv6n3-032.

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Os linfomas primários da mama (LPM) são neoplasias incomuns, representando aproximadamente 0,5% das neoplasias mamárias e 2% dos linfomas extra nodais. Os sintomas associados ao LPM são semelhantes aos encontrados em outras lesões malignas da mama. A histologia associada à imuno-histoquímica (IHQ) é fundamental para o diagnóstico desses tumores, os quais, em sua maioria, apresentam-se imunofenotipicamente derivados da linhagem B. A sua raridade ainda não permitiu a padronização da terapêutica mais apropriada. O presente relato consiste em uma paciente apresentando nódulo em mama direita há apr

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6

Benez, Mariana Mancini, Rone Charles Maranho, Gustavo Barizon Maranho, et al. "Proteome of germinating and dormant axillary buds of sugarcane and analysis of sprouting-related proteins." APRIL 2019, no. 12(01): 2019 (April 20, 2019): 15–24. http://dx.doi.org/10.21475/poj.12.01.19.p1371.

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The germination potential of the axillary buds is crucial for the installation of new sugarcane crop and is highly relevant for the maintenance of the crop during the regrowth cycles. In this way, 1-DE-UPLC-ESI-Q-TOF system of mass spectrometry in a shotgun approach evaluated total and differential proteome of germinating and dormant axillary buds of cultivar RB867515 in second ratoon. The current paper investigates whether differently expressed proteins can be detected in germinating axillary buds or not. The proteome of germinative and dormant axillary buds were obtained using TCA/acetone in

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7

Stepan Giljević, Jasminka. "Rana dijagnostika malignih tumora dječje dobi." Paediatria Croatica 69, Suppl 1 (2025): 23–24. https://doi.org/10.13112/pc.988.

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Maligni tumori dječje dobi predstavljaju tek oko 1% svih malignih tumora te ih svrstavamo u rijetke bolesti. Razlikuju se od tumora odrasle dobi prema vrsti tumorskih stanica od kojih nastaju i prema mehanizmima maligne transformacije. Od ukupnog broja oboljelih otprilike 10% ima predispoziciju za razvoj hereditarnog malignog tumora. Biološki, tumori dječje dobi češće su bržeg rasta što se klinički manifestira ranijom progresijom bolesti (1). Prema dobnim skupinama u dobi do treće godine najčešća je pojava embrionalnih tumora mozga, neuroblastoma, rabdomiosarkoma, hepatoblastoma, retinoblastom

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8

Caixeta, Amanda Ramos, Maria Caroline Martins Machado, Nathasia Christyelle Rolim de Araújo, et al. "Tumor de células germinativas não seminomatoso." Brazilian Journal of Health Review 5, no. 5 (2022): 18631–42. http://dx.doi.org/10.34119/bjhrv5n5-070.

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Introdução: o Tumor de Células Germinativas Não Seminomatoso (TCGNS) é responsável por 1% das neoplasias em homens, sendo mais invasivo e agressivo quando comparado ao subtipo Seminomatoso. É o câncer de testículo com maior índice de metástase para ossos, SNC, fígado e pulmões. Apresentação do caso: JCN, sexo masculino, 25 anos, internado em serviço terciário com quadro de dispneia aos mínimos esforços, hemoptise, perda de peso e dor torácica de início há 06 meses. Iniciada investigação de massa mediastinal encontrada após exames de imagem, sendo classificada como carcinoma embrionário não sem

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9

Scandiuzzi, Rafael, Rayane Morais Costa, and Leticia Alves de Melo. "Relato de caso: Tumor testicular bilateral metacrônico." Brazilian Journal of Health Review 5, no. 5 (2022): 19799–804. http://dx.doi.org/10.34119/bjhrv5n5-159.

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O câncer dos testículos é relativamente raro, porem é a malignidade sólida mais comum nos homens jovens, sendo os tumores de células germinativas correspondentes a 90- 95% dos casos. A maioria dos tumores é derivada de células germinativas e classificado como câncer de células germinativas seminomatosas e câncer de células germinativas não seminomatosas. O diagnóstico inclui a realização de ultrassonografia escrotal seguida de exames radiográficos, dosagem de marcadores tumorais séricos e orquiectômica inguinal radical com anátomo- patológico. O tratamento dos tumores não seminomatosos consis

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10

Plomp, Marco, J. Michael McCaffery, Ian Cheong, et al. "Spore Coat Architecture of Clostridium novyi NT Spores." Journal of Bacteriology 189, no. 17 (2007): 6457–68. http://dx.doi.org/10.1128/jb.00757-07.

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ABSTRACT Spores of the anaerobic bacterium Clostridium novyi NT are able to germinate in and destroy hypoxic regions of tumors in experimental animals. Future progress in this area will benefit from a better understanding of the germination and outgrowth processes that are essential for the tumorilytic properties of these spores. Toward this end, we have used both transmission electron microscopy and atomic force microscopy to determine the structure of both dormant and germinating spores. We found that the spores are surrounded by an amorphous layer intertwined with honeycomb parasporal layer

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11

Guidoti, Daniela Granella Gomes, David Teixeira Guidoti, Adriano Lopes Romero, et al. "Kaurenoic acid from Annona squamosa L. exhibits antiproliferative effect on human tumor cell lines and induces apoptosis in Aspergillus nidulans." Revista Fitos 13, no. 2 (2019): 122–36. http://dx.doi.org/10.17648/2446-4775.2019.716.

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Annona squamosa is a source of bioactive compounds, with several pharmacological activities. However, tests are needed to confirm the safety of these compounds in terms of cytogenotoxic potential and their possible medicinal activity. Thus, the aims of the present study were to isolate kaurenoic acid from sugar apple peel and determine its antiproliferative activity in nine human tumor cell lines and mutagenic activity in germinating Aspergillus nidulans conidia. Chemical extraction resulted in the isolation of kaurenoic acid, a terpene that demonstrated a cytostatic effect at concentrations o

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12

Zhong, Juanjuan, Jinlan Chen, Bei Wang, et al. "OIP5-AS1: A Fascinating Long Noncoding RNA in Carcinoma." Current Pharmaceutical Design 27, no. 46 (2021): 4699–706. http://dx.doi.org/10.2174/1381612827666210927105558.

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Background: It is substantiated that LncRNAs are associated with carcinoma progression. OIP5- AS1 is a tumor-related carcinoma suppressor lncRNA, previously discovered in zebrafish, which is involved in the progression of a variety of cancers, has a regulatory effect on carcinoma, and interacts with miRNA and other biomolecules to affect the physiological and pathological processes of carcinoma cells. This article will discuss the effect of OIP5-AS1 in various cancers and its regulatory mechanism. Methods: This paper summarized and analyzed OIP5-AS1, which functions on the germination and prog

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13

Petrov, L. O., D. A. Golovkov, R. I. Moshurov, S. S. Malev, and A. A. Fedenko. "A rare case of solitary fibrous pelvic tumor." Research and Practical Medicine Journal 10, no. 1 (2023): 126–33. http://dx.doi.org/10.17709/2410-1893-2023-10-1-11.

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Non-organ retroperitoneal tumors are a heterogeneous group of malignant neoplasms that develop from different types of connective tissue, which in turn determines the variety of histological forms. More than 3,000 new cases of soft tissue sarcomas are registered an‑ nually in Russia, which is 1 % of all malignant neoplasms. In 2021, 3150 new cases of malignant neoplasms of connective and other soft tissues were detected for the first time. Retroperitoneal sarcomas account for 10–15 % of all types of soft tissue sarcomas. Diagnosis and treatment of non‑organ retroperitoneal tumors is an extreme

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14

Likhvantseva, V. G., O. A. Anurova, S. E. Astakhova, M. V. Vereshchagina, V. E. Ovanesyan, and E. V. Stepanova. "Expression of Vascular Endothelial Growth Factor in Uveal Melanoma." Ophthalmology in Russia 18, no. 4 (2021): 914–21. http://dx.doi.org/10.18008/1816-5095-2021-4-914-921.

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A prerequisite for the growth, progression and metastasis of malignant tumors of any localization is the development of its own vascular network. Newly formed vessels not only nourish the primary tumor, but also create conditions for the spread of tumor cells through the circulatory system and the formation of distant metastases. Angiogenesis is able to launch a small population of tumors from 100–300 cells that have accumulated genetic aberrations and have begun to express proangigenic molecules. The phenomenon is known as “transformation of tumor cells into angiogenic phenotype”. A tumor wit

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15

Tarasenko, S. V., A. A. Natalsky, O. D. Peskov, et al. "Comparison of access to the superior mesenteric arteryduring the execution of the pancreatoduodenal resectionin patients with borderline-resectable cancer of the pancreatic head." Experimental and Clinical Gastroenterology, no. 10 (January 18, 2023): 97–102. http://dx.doi.org/10.31146/1682-8658-ecg-206-10-97-102.

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The purpose of the study is to study the technical aspects of surgical treatment of borderline-resectable pancreatic head tumors Materials and methods. An analysis of the implementation of the DA was performed in 102 patients with borderline-resectable pancreatic head cancer. In 20% of patients, the tumor grows in the region of the celiac-mesenteric gap of the tumor (mesopancreas germination). In 25.6%, the tumor grows on the wall of the portal-superior mesenteric segment. In 12.7%, the tumor tightly covers the walls of the branches of the celiac trunk or superior mesenteric artery by less tha

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16

Duda, K. М., and V. І. Medved. "Pregnancy and delivery in women with tumors of central nervous system (Clinical observation)." Reproductive health of woman, no. 7-8 (November 1, 2021): 23–27. http://dx.doi.org/10.30841/2708-8731.7-8.2021.250827.

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The tumors of the central nervous system (CNS) in women commonly are diagnosed at the age of 35-45 years old. Their rate is about 2-3.2 cases per 100,000. The tumors of the CNS are not a common problem during pregnancy, however annually 4-5 women with this diagnosis visit the Department of Internal Pathology of Pregnant Women in the State Institution “Institute of Pediatrics, Obstetrics and Gynecology named after academic О.M. Lukyanova of National Academy of Medical Sciences of Ukraine”.The risk of CNS tumor development during pregnancy is identical that in non-pregnant women, but pregnancy a

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17

K.М., Duda, and Medved V.І. "Pregnancy and delivery in women with tumors of central nervous system (Clinical observation)." Reproductive Health of Woman, no. 7-8 (November 1, 2021): 23–27. https://doi.org/10.30841/2708-8731.7-8.2021.250827.

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The tumors of the central nervous system (CNS) in women commonly are diagnosed at the age of 35-45 years old. Their rate is about 2-3.2 cases per 100,000. The tumors of the CNS are not a common problem during pregnancy, however annually 4-5 women with this diagnosis visit the Department of Internal Pathology of Pregnant Women in the State Institution “Institute of Pediatrics, Obstetrics and Gynecology named after academic О.M. Lukyanova of National Academy of Medical Sciences of Ukraine”. The risk of CNS tumor development during pregnancy is identical that in non-pregnant women, bu

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18

Silva, Daniel Facundo da, Fernando Barroso Duarte, Karine Sampaio Nunes Barroso, João Paulo de Vasconcelos Leitão, Beatriz Stela Gomes de Souza Pitombeira Araujo, and Natália Costa Bezerra Freire. "Transplante autólogo de células tronco hematopoiéticas em pacientes com tumor de células germinativas refratário: a experiência inicial do Hospital Universitário Walter Cantídio." Revista de Medicina da UFC 64, no. 1 (2024): e89265. http://dx.doi.org/10.20513/2447-6595.2024v64n1e89265.

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Introdução: O uso do transplante autólogo de células tronco hematopoiéticas (aTCTH) como tratamento para tumores de órgãos sólidos, ainda que restrito a um grupo pequeno de neoplasias, avançou nos últimos anos, principalmente nos tumores de células germinativas refratários/recidivados (TCG-RR). O serviço de Transplante de Medula Óssea (TMO) do Hospital Universitário Walter Cantídio (HUWC) oferece essa terapia para pacientes do nordeste brasileiro, através do serviço público, embora enfrente desafios relacionados à aquisição de medicações e demografia local. Objetivos: Descrever as característi

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19

Sanginov, D. R., Z. H. Huseynzoda, R. A. Zoirov, M. Kh Naibo, and M. Mahmad. "The results of surgical treatment of extra-organ retroperitoneal tumors." Health care of Tajikistan, no. 4 (February 3, 2022): 83–88. http://dx.doi.org/10.52888/0514-2515-2021-351-4-83-88.

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Aim. To analyze the immediate and long-term results of surgical treatment of patients with non-organ retroperitoneal tumors.Material and research methods. A retrospective analysis of medical records (medical history, outpatient records) of patients with non-organ retroperitoneal tumors treated in the Uro-procto-oncology Department for the period 2017-2020 was carried out.Results and discussion. It was found out that the prevalence of the tumor process according to the international TNM classification of UICC was as follows: stage II– 5 (21.7%), stage III - 14 (60.8%), and stage IV – 4 (17.4%).

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20

Canal, Brunno Gonçalves, Felipe Sampaio Soares Aspahan, Antonio Carlos Bulian Júnior, Hebert Vitória dos Anjos, and Rogério Ignacio de Oliveira. "Teratoma gigante de mediastino: relato de caso." Brazilian Journal of Health Review 8, no. 1 (2025): e77273. https://doi.org/10.34119/bjhrv8n1-279.

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Tumor de células germinativas mediastinal é uma condição rara que pode se apresentar como massa mediastinal gigante. Um homem de 23 anos com quadro de dispneia e dor pleurítica à esquerda foi submetido a tomografia de tórax e abdome com achado de massa mediastinal anterior medindo 20,1x10,7x12,5cm, com doença localizada em tórax. Realizada biópsia aberta evidenciando tumor de células germinativas não seminoma. Sucedida quimioterapia baseada em cisplatina, com redução importante dos marcadores, porém com rápida elevação após o término do último ciclo. Foi indicada abordagem cirúrgica com ressec

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21

Peixoto, Bianca Fadul de Oliveira, Ciro de Castro Botto, Gustavo Assumpção Teixeira, Eduardo Ruas Martins Batista, Marcelo de Paula Lima, and Ana Claúdia Fernandes Azarias. "Tumor do saco vitelínico em mediastino anterior: um relato de caso." Revista Eletrônica Acervo Saúde 12, no. 12 (2020): e5031. http://dx.doi.org/10.25248/reas.e5031.2020.

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Objetivo: Relatar um caso raro de tumor de células germinativas não seminomatoso do tipo “Yolk Sac Tumor” ou “Saco vitelínico” em mediastino anterior em paciente jovem com desfecho desfavorável. Detalhamento do caso: Homem jovem com apresentação inicial insidiosa de mal-estar e febre em domicílio, com procuras frequentes ao atendimento primário. Com a progressão dos sintomas, foi submetido à radiografia de tórax, sendo evidenciado alargamento de mediastino anterior e optou-se por internação para elucidação diagnóstica. Cursou com piora gradativa dos sintomas e com aumento exponencial do tamanh

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22

Gököz, Özay, Loretta Presenti, Giuseppina Gambacorta, et al. "Skin-Type Adnexal Tumor With Trichoblastic Germinative Differentiation in the Breast." International Journal of Surgical Pathology 19, no. 4 (2009): 527–33. http://dx.doi.org/10.1177/1066896909337383.

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23

Gomes Filho, Firmino de Azevedo, and Sandra Regina de Souza Viola. "Tumores Germinativos Avançados - Tratamento com PVB." Revista Brasileira de Cancerologia 33, no. 2 (2023): 159–66. http://dx.doi.org/10.32635/2176-9745.rbc.1987v33n2.3200.

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Treze pacientes portadores de tumores germinativos avançados foram tratados nos últimos três anos no Hospital de Oncologia --- INAMPS com esquema quimioterápico PVB. Destes, um paciente não é avaliável visto ter recebido dois ciclos incompletos e somente um tem apresentação extragonadal, sendo os demais primitivos do testículo. Oito pacientes apresentaram PC (66,7%) e quatro RP (33,3%). Duas recidivas ocorreram 12 e 16 meses após início da quimioterapia. Houve três óbitos, após RP dois por falha ao esquema de 2. linha (VP16 + CDDP) e um por evolução de doença após abandono de tratamento durant

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24

Paiva, Carlos Eduardo, Lia Rachel Gaspari, Julio César Donato, and Odair Carlito Michelin. "Tumor de células germinativas de testículo simulando câncer de pâncreas." Revista Brasileira de Cancerologia 52, no. 3 (2006): 253–56. http://dx.doi.org/10.32635/2176-9745.rbc.2006v52n3.1872.

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Durante as últimas duas décadas, os tumores de células germinativas de origem gonadal ou extragonadal se transformaram no modelo de tumor sólido curável, principalmente em função da boa sensibilidade à quimioterapia baseada em cisplatina. Em cerca de 90% dos casos, se apresentam com sintomas testiculares e nos casos restantes em função de metástases. Apresentamos um caso atípico que simulou inicialmente um câncer de pâncreas, atrasando o diagnóstico. Salientamos a importância de se pensar em tumor de células germinativas, principalmente em homens jovens com icterícia obstrutiva e massa em topo

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25

Benhoummad, Othman, Mohamed Chehbouni, Youssef Rochdi, and Abdelaziz Raji. "Congenital cervical teratoma: about a case." European Journal of Medical and Health Sciences 3, no. 3 (2021): 35–38. http://dx.doi.org/10.24018/ejmed.2021.3.3.814.

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Congenital cervical teratomas are benign but serious germinative cell tumors. The possibility of air compression structures and the risk of invasion of vascular and nervous noble elements are crucial prognostic factors in this kind of tumor. Prenatal diagnosis raises on ultrasound examination precising locoregional consequences of the tumor and surgical possibilities. In the propitious cases, prenatal MRI examination is useful to precise tumor’s limits and cerebral status of the foetus. At birth, coordinate management involving anaesthetists, paediatricians and specialized surgeons decrease mo

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26

Cavalheiro, Sérgio, André Leandro Amaral, Nadjla Saba Silva, Fernando Menezes Braga, and João Norberto Stávale. "Tumor rabdóide primário do sistema nervoso central." JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 9, no. 1 (2017): 19–23. http://dx.doi.org/10.22290/jbnc.v9i1.259.

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Os autores apresentam um caso de tumor rabdóide primário do sistema nervoso central, frequentemente confundido com tumor neuroectodérmico primitivo (PNET), devido às semelhanças clínicas, histológicas e radiológicas. Acomete mais comumente crianças menores de dois finos e ocorre predominantemente em fossa posterior. A célula rabdóide é encontrada em todos os casos, mas na grande maioria é associada à histologia clássica do PNET. O perfil imunoistoquímico é único, sendo positivo na maioria dos tumores ao antígeno de membrana epitelial, vimentina e actina de músculo liso, e constantemente negati

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Sulfianti, Asri, Nur Hasanah, Agung Eru Wibowo, Kurnia Agustini, and I. Made Artika. "Potency of Curcuma aeruginosa as A Chemopreventive Candidate Agent on 7,12-Dimethylbenz[a]anthracene (DMBA)-Induced Rat Spleen." ANNALES BOGORIENSES 23, no. 2 (2020): 58. http://dx.doi.org/10.14203/ann.bogor.2019.v23.n2.58-65.

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Present investigation shows that the extract of C. aeruginosa attenuates DMBA-induced spleen carcinogenesis in Wistar rats. Three-week female Wistar rats were treated with three different C. aeruginosa extract doses (CA1: 40 mg/200 g body weight, BW; CA2: 80 mg/200 g BW; CA3: 160 mg/200 g BW) and were induced with DMBA after one-week administration of these doses. A commercial immunostimulant, and DMBA only were also given to each group as positive and negative control, respectively. The development of tumors was evaluated by investigating the incidence of tumor and tumor multiplicity during t

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Klochikhin, A. L., and V. V. Byrikhina. "Case report of rare melanoma of inferior part of frontal sinus and ethmoidal labyrinth with transition to orbital fat." Russian Otorhinolaryngology 21, no. 6 (2022): 110–13. http://dx.doi.org/10.18692/1810-4800-2022-6-110-113.

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Malignant tumors of the mucous membrane of the paranasal sinuses and nasal cavity are quite rare, which is from 0,2 to 1,3% of all malignant tumors of the head and neck. Melanoma of the mucous membrane of the paranasal sinuses and nasal cavity is less than 5% of all neoplasms of this localization and less than 1% of all melanomas. Melanoma is one of the most dangerous, often recurrent, metastatic malignant tumors. More often, melanoma occurs in the maxillary sinus, less often it is diagnosed in the frontal sinus. The average age of patients with melanoma is 58,7 years. Men and women get sick a

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da Silveira, Matheus Antonio, Juliana Fernandes Pavoni, Alexandre Colello Bruno, Gustavo Viani Arruda, and Oswaldo Baffa. "Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure." Gels 8, no. 9 (2022): 582. http://dx.doi.org/10.3390/gels8090582.

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Craniospinal irradiation (CSI) is a complex radiation technique employed to treat patients with primitive neuroectodermal tumors such as medulloblastoma or germinative brain tumors with the risk of leptomeningeal spread. In adults, this technique poses a technically challenging planning process because of the complex shape and length of the target volume. Thus, it requires multiple fields and different isocenters to guarantee the primary-tumor dose delivery. Recently, some authors have proposed the use IMRT technique for this planning with the possibility of overlapping adjacent fields. The hi

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Oliveira Kato, Ludmila, Julia de Sousa Oliveira, Lorrana Andrade Silva, Mariana Melo Martins, Franco Fernandes Neto, and Edson Antonacci Júnior. "SEMINOMA INTRA-ABDOMINAL RELACIONADO À CRIPTORQUIDIA: UM RELATO DE CASO." Relatos de Casos Cirúrgicos do Colégio Brasileiro de Cirurgiões 8, no. 3 (2022): 1–5. http://dx.doi.org/10.30928/2527-2039e-20223270.

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Introdução: O seminoma é um tipo de tumor de células germinativas (TCG). Tais neoplasias são responsáveis por menos de 1% dos cânceres que acometem o sexo masculino. O criptorquidismo aumenta de 10 a 40 vezes o risco de seminoma, enquanto história pessoal de TCG aumenta o risco de novo tumor primário em cerca de 10 vezes. Relato do caso: J.F.S., 54 anos, queixava-se de lombalgia frequente. Possui história prévia de criptorquidismo esquerdo. Ao exame físico, havia grande massa indolor na região infraumbilical. A ressonância mostrou uma massa pélvica heterogênea sem plano de clivagem com as alça

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Serpuhovitin, S. Yu, L. Ye Kirpatovskaya, and I. S. Komolov. "Present-day methods of therapy of pituitary adenomas." Problems of Endocrinology 41, no. 1 (1995): 26–29. http://dx.doi.org/10.14341/probl11343.

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Pituitary tumors often called adenomas, mainly come from the anterior pituitary and in about 90% of cases secrete large quantities of one or more pituitary hormones, which leads to changes in homeostasis and the occurence of specific endocrine diseases such as acromegaly, a lactorrhea-amenorrhea syndrome, a Cushing's disease, etc. The clinical picture of both hormone-secreting and non-secreting pituitary tumors can also be caused by their germination of their interconnected structure of the pituitary gland, parasellar areas with impaired brain function. The etiology of pituitary tumors i

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Plaksyvyi, Oleksandr, Ihor Kalutskyi, and Olga Mazur. "CASE OF MALIGNATION OF GIANT INVERTED PAPILLOMA OF THE NOSE." Clinical anatomy and operative surgery 20, no. 1 (2021): 35–38. http://dx.doi.org/10.24061/1727-0847.20.1.2021.06.

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Inverted transitional cell papilloma (Schneider papilloma), a rare benign tumor, accounts for about 0.5% of all neoplasms of the nose. Usually unilateral, recurrences of the tumor can occur after 5-10 years. The clinical case testiﬁ es to the gigantic size of the neoplasm, the germination of the inverted papilloma into the paranasal sinuses, the malignancy of the process and the metastasis of the tumor, which was not previously described. The main treatment for preventing recurrence is radical surgery, possibly with ligation of the external carotid artery.

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Pereira, Rosana Marques, Edson Michalkiewicz, Mara Albonei Pianovski, et al. "Tratamento do tumor do córtex adrenal na infância." Arquivos Brasileiros de Endocrinologia & Metabologia 49, no. 5 (2005): 747–52. http://dx.doi.org/10.1590/s0004-27302005000500015.

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O tumor do córtex adrenal (TCA) na infância é raro. Entretanto, no Paraná sua incidência é 15 vezes maior do que a observada em outros países. A mutação germinativa R337H TP53, presente em mais de 95% dos nossos pacientes, provavelmente está relacionada à maior incidência. Cento e vinte e cinco pacientes foram tratados no período de 1966 a 2003. A cirurgia é o único tratamento curativo. Em nossa experiência, tumores no estádio I, ausência de spillage durante a cirurgia e ausência de trombo são parâmetros relacionados à maior sobrevida. Dados preliminares mostram que a associação de etoposídeo,

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Prados, Victória Oliveira, Daniela Fiuza Rocha, Jullyana Borba De Sousa, et al. "Tumor de células germinativas não seminomatoso: Um relato de caso / Non seminomatous germ cell tumor: A case report." Brazilian Journal of Health Review 4, no. 5 (2021): 21794–802. http://dx.doi.org/10.34119/bjhrv4n5-269.

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Vijayakrishnapillai, Lalu, John Desmarais, Michael Groeschen, and Michael Perlin. "Deletion of ptn1, a PTEN/TEP1 Orthologue, in Ustilago maydis Reduces Pathogenicity and Teliospore Development." Journal of Fungi 5, no. 1 (2018): 1. http://dx.doi.org/10.3390/jof5010001.

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The PTEN/PI3K/mTOR signal transduction pathway is involved in the regulation of biological processes such as metabolism, cell growth, cell proliferation, and apoptosis. This pathway has been extensively studied in mammals, leading to the conclusion that PTEN is a major tumor suppressor gene. PTEN orthologues have been characterized in a variety of organisms, both vertebrates and non-vertebrates, and studies of the associated PTEN/PI3K/mTOR pathway indicate that it is widely conserved. Studies in fungal systems indicated a role of PTEN in fungal defense mechanisms in Candida albicans, and in th

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Hoang, Mai P., and Brian M. Levenson. "Cystic Panfolliculoma." Archives of Pathology & Laboratory Medicine 130, no. 3 (2006): 389–92. http://dx.doi.org/10.5858/2006-130-389-cp.

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AbstractPanfolliculoma is a rare follicular neoplasm with differentiation toward both upper (infundibulum and isthmus) and lower (stem, hair matrix, and bulb) segments of a hair follicle. We present an unusual case of cystic panfolliculoma. A 33-year-old Hispanic woman presented with an 8-month history of a 3.0-cm cystic scalp mass. The lesion was excised, and the histologic sections showed a cystic follicular neoplasm that contained corneocytes in basket-woven and laminated array, trichohyalin granules of the inner root sheath, germinative cells, papillae, matrical cells, and “shadow” cells.

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Ferreira, Laís Gomes, Heloísa Rocha Ribeiro, Luise Schwan Soares, et al. "Disgerminoma em paciente com Síndrome de Down à propósito de caso." REVISTA DELOS 18, no. 63 (2025): e3541. https://doi.org/10.55905/rdelosv18.n63-053.

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Introdução: Pacientes com síndrome de Down (SD) apresentam um espectro único de malignidades, com um risco 10 a 20 vezes maior de leucemias agudas e uma incidência acentuadamente diminuída de tumores sólidos. O disgerminoma é um tumor maligno de células germinativas do ovário e que apesar de ser um tumor sólido, tem uma incidência aumentada em pacientes com SD. É frequente em mulheres jovens e pode ser assintomático ou apresentar diversos sintomas. O seu diagnóstico definitivo é através da análise histopatológica e seu tratamento normalmente é cirúrgico, associado ou não a quimioterapia adjuva

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Rondinelli, Patrícia Imperatriz Porto, Carlos Alberto Martinez Osório, and Luís Fernando Lopes. "Tumores de células germinativas intracranianos na infância: avaliação de 14 casos." Arquivos de Neuro-Psiquiatria 63, no. 3b (2005): 832–36. http://dx.doi.org/10.1590/s0004-282x2005000500021.

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Este estudo avalia o diagnóstico, a terapia e a sobrevida de 14 pacientes com tumor de células germinativas intracraniano durante o período entre 1991 e 2001. Onze pacientes eram do sexo masculino e três do feminino. A média de idade do grupo foi 12,5 anos (20 dias-18 anos). Na admissão, os mais comuns sintomas foram cefaléia (10/14), vômitos (6/14) e visuais (6/14). Os tumores estavam localizados em região hipotalâmica/hipofisária em 10 casos, suprasselar em 3 casos e intraparenquimatosa em 1 caso. Histologicamente, havia 1 caso de carcinoma embrionário, 5 de germinomas, 2 de teratoma maduro,

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Jeromini, Tatiane Sanches, Thais Soares Pereira, Cibele Chalita Martins, and Givanildo Zildo da Silva. "Overcoming dormancy in Bauhinia scandens seeds." Semina: Ciências Agrárias 41, no. 4 (2020): 1189. http://dx.doi.org/10.5433/1679-0359.2020v41n4p1189.

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Bauhinia scandens, an ornamental climbing vine, recently introduced in Brazil, in 2006 which has been gaining prominence due to its anti-tumor medicinal properties. A common feature amongst species of the Fabaceae family is dormancy due to the impermeability of the integument of the seed to water. The demand for seedlings of this species makes it necessary to elucidate the germination process and initial seedling growth. The objective of this study was to determine a method to overcome dormancy, thereby promoting seed germination and initial growth of B. scandens seedlings. The seeds were subj

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Hareesh, T., Rajesh Gunaga, R. Vasudeva, K. Shivanna, R. Shaanker, and Gladwin Joseph. "Variation for seedling vigour among half-sib families in Nothapodytes nimmoniana (Grah.) Mabber: An anti-tumor drug yielding plant." Journal of Non-Timber Forest Products 15, no. 3 (2008): 161–65. http://dx.doi.org/10.54207/bsmps2000-2008-py2s2k.

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Nothapodytes nimmoniana has attained international focus recently due to the occurrence of an important group of alkaloids, camptothecin and its derivates. Efforts are being made to domesticate this species for its large scale cultivation for realization of economic utilization by the industries. However, there is a paucity of information on the degree and extent of genetic control for any traits in this species. In this background an experiment was conducted to assess the variation for fruits and seed traits among half-sib families. Half sib families obtained from ten open pollinated individu

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Santos, Adrialdo José, Suzana Maria Fleury Malheiros, Lia Raquel Rodrigues Borges, Carlos Dzik, Darcio G. Nalli, and Alberto Alain Gabbai. "Acidente vascular cerebral isquêmico após quimioterapia com cisplatina, etoposide e bleomicina: relato de caso." Arquivos de Neuro-Psiquiatria 61, no. 1 (2003): 129–33. http://dx.doi.org/10.1590/s0004-282x2003000100027.

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Relatamos o caso de um homem de 20 anos, com diagnóstico de tumor de células germinativas, que apresentou acidente vascular cerebral isquêmico durante quimioterapia com cisplatina, etoposide e bleomicina. Os casos relatados na literatura foram revisados, bem como os diferentes mecanismos fisiopatológicos implicados na toxicidade vascular deste esquema quimioterápico.

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Gadelkareem, Rabea A., Ayman A. Elqady, Sayed K. Abd-Elshafy, Hisham Imam, and Hassan A. Abolella. "Isolated Renal Hydatid Cyst Misdiagnosed and Operated as a Cystic Renal Tumor." Medical Principles and Practice 27, no. 3 (2018): 297–300. http://dx.doi.org/10.1159/000488878.

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Objective: The aim of this work is the presentation of a case of isolated renal hydatid cyst with novel findings and an unusual surgical scenario. Clinical Presentation and Intervention: A 54-year-old female patient presented with left loin pain and a palpable left renal mass. Imaging described a well-demarcated left renal cystic lesion with a double-layer wall. Radical nephrectomy was performed due to the possibility of malignancy. On retrograde revision, the double-layer wall represented the detached germinative membrane of a hydatid cyst that was confirmed by histopathology. Conclusion: Iso

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Van Petten de Vasconcelos Azevedo, Fernanda, Daiana Silva Lopes, Mariana Alves Pereira Zóia, et al. "A New Approach to Inhibiting Triple-Negative Breast Cancer: In Vitro, Ex Vivo and In Vivo Antiangiogenic Effect of BthTx-II, a PLA2-Asp-49 from Bothrops jararacussu Venom." Biomolecules 12, no. 2 (2022): 258. http://dx.doi.org/10.3390/biom12020258.

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Phospholipases A2 (PLA2) represent a superfamily of enzymes widely distributed in living organisms, with a broad spectrum of pharmacological activities and therapeutic potential. Anti-angiogenic strategies have become one of the main tools in fighting cancer. In this sense, the present work reports the inhibition of tumor angiogenesis induced by Asp-49 BthTX-II using in vitro, ex vivo and in vivo approaches. We demonstrate that BthTx-II inhibited cell adhesion, proliferation, and migration of human umbilical vein endothelial cells (HUVEC), as well as caused a reduction in the levels of endothe

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SALOMÃO, A. N., I. R. I. SANTOS, S. C. B. R. JOSÉ, J. P. DA SILVA, and B. G. LAVIOLA. "Methods to assess the viability of cryopreserved Jatropha curcas L. seed germplasm." Revista Brasileira de Plantas Medicinais 18, no. 2 (2016): 391–98. http://dx.doi.org/10.1590/1983-084x/15_175.

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ABSTRACT Jatropha curcas L. is a plant species with many potential applications, especially medicinal uses (hypoglycemic, anti-inflammatory, haemostatic, healing, anti-tumor). The objective of this study was to test germination in moist paper rolls for whole seeds and in vitro for excised embryonic axes, in an attempt to identify the best method to assess the quality of J. curcas seed germplasm, cryopreserved with different water contents. The experimental sample with a 6.2% moisture content (MC) was divided in subsamples which were hydrated and dehydrated for 0 (control), 4, 8, 11 and 24h. Th

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Pokharel, Sairil, S. Karki, A. Pradhan, and S. Agrawal. "Melanotrichoblastoma: A Rare Case Report from B. P. Koirala Institute of Health Sciences, Dharan, Nepal." Birat Journal of Health Sciences 2, no. 1 (2017): 145–47. http://dx.doi.org/10.3126/bjhs.v2i1.17295.

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Melanotrichoblastoma is a variant of pigmented trichoblastoma. It shows heavily pigmented epithelial lobules and differentiaion toward the hair bulb. Abundant dendritic melanocytes are found within the tumor masses. These melanocytes show positivity for S100 protein, HMG45/gp 100 and tyrosinase. The case is being reported because of its rarity.A twenty eight year lady presented to Dermatology OPD with a single nodular lesion on the right temporal region since last five years. Punch biopsy was done. Haematoxylin and eosin stained slides were studied and immunohistochemistry analysis was also do

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Janku, Filip, Siqing Fu, Ravi Murthy, et al. "383 First-in-man clinical trial of intratumoral injection of clostridium Novyi-NT spores in combination with pembrolizumab in patients with treatment-refractory advanced solid tumors." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A408. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0383.

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BackgroundIntratumorally injected Clostridium novyi-NT (non-toxic), an attenuated strain of C. novyi that lacks production of the lethal alpha toxin, replicates within hypoxic tumor regions and elicits tumor-confined cell lysis. Early clinical and translational data suggest that intratumoral injection of C. novyi-NT is feasible, demonstrates early signals of anti-tumor activity and induction of the host immune response, which supports additional studies in combination with immune checkpoint inhibitors.MethodsThis first-in-human study (NCT03435952) enrolls patients with injectable, treatment-re

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Lewis, Mark E., та Fred A. Bliss. "Tumor Formation and β-Glucuronidase Expression in Phaseolus vulgaris Inoculated with Agrobacterium tumefaciens". Journal of the American Society for Horticultural Science 119, № 2 (1994): 361–66. http://dx.doi.org/10.21273/jashs.119.2.361.

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Ten common bean (Phaseolus vulgaris L.) lines—including cultivars, breeding lines, and one wild line—were evaluated for susceptibility to Agrobacterium tumefaciens strain C58 by stab-inoculating intact shoot tips of germinating seeds. Significant differences for tumor frequency and size were found on the resulting 3-week-old seedlings. UW 325, a wild bean, had the highest rate of tumorigenesis; `Olathe', a dry bean cultivar, had the lowest. Uninoculated excised shoot tips cultured in media with BA or BA plus NAA exhibited differences in phytohormone sensitivity, as evidenced by callusing and r

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Guimarães, Blenda Dias, Beatriz Passos Medeiro, and Guilherme Munhoz Lopes. "Disgerminoma de ovário e marcadores tumorais – relato de caso." Brazilian Journal of Health Review 7, no. 3 (2024): e70725. http://dx.doi.org/10.34119/bjhrv7n3-417.

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O presente artigo objetiva-se seu estudo em tumores ovarianos, especialmente os derivados de células germinativas, sendo o disgerminoma o tipo mais comum de neoplasia destas células. Visa suscitar a assertiva investigação para diagnóstico precoce do tumor de células germinativas ovarianas, com enfoque no disgerminoma, de forma que, quando diagnosticado precocemente é possível a redução de futuras repercussões negativas na vida reprodutiva da mulher. O disgerminoma, ocorrente apenas em células germinativas, é considerado raro e de difícil identificação. Na maioria dos casos documentados, este s

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Costa, Thaline Ravena Nunes, Vitor de Deus da Rocha Ribeiro Gonçalves, Pedro Borges Bomfim Júnior, Luís Felipe Coelho Alves, and José Nazareno Pearce de Oliveira Brito. "Tumor de seio endodérmico no III ventrículo." JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 32, no. 1 (2021): 72–80. http://dx.doi.org/10.22290/jbnc.v32i1.1946.

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Tumor do seio endodérmico (tumor do saco vitelino) é um subtipo histológico dos tumores de células germinativas não-germinomatosos. No sistema nervoso central (SNC), geralmente, localizam-se na linha média (região pineal). As apresentações clínica e radiológica desses tipos de tumores necessitam de uma avaliação singular de marcadores tumorais. Relatamos um paciente de 12 anos, sexo masculino com sinais e sintomas de hipertensão intracraniana, diminuição da acuidade visual que evoluiu com hemiparesia esquerda e distúrbios do equilíbrio e coordenação. A ressonância magnética de crânio mostrou m

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Lima, Lucas Lopes de Andrade, Mariana Ribeiro Silva, Leonardo Barbosa De Mariz Nogueira, Nilo Sousa Ferreira Rodrigues Sobrinho, Beatriz Xavier Lira, and Herverson Gabriel dos Santos. "Uso da cintilografia para diagnóstico e avaliação do paraganglioma." Anais da Faculdade de Medicina de Olinda 1, no. 12 (2024): 115–21. https://doi.org/10.56102/afmo.2024.331.

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O paraganglioma é um tumor do sistema endócrino com característica hereditária significativa que afeta pessoas mais jovens, causando dores de cabeça, palpitações e diaforese. Esse tumor pode estar presente na região da cabeça e pescoço como um tumor do corpo carotídeo e tem baixa incidência de metástase. Embora vários exames possam ser utilizados, como tomografia computadorizada e ressonância magnética, a cintilografia é útil para o diagnóstico e avaliação do paraganglioma. Bancos de dados online, como Scielo, Oxford Academic, PubMed e The Journal of Nuclear Medicine, foram utilizados para com

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