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Dissertations / Theses on the topic 'Tumor initiating cells (CICs)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Scalabrini, Luiza Coimbra. "O papel da quinase Aurora A na biologia das células iniciadoras de turmor pulmonares com mutação em KRAS." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11042017-082202/.

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Mutações ativadoras no gene KRAS são prevalentes em cancer de pulmão e a as vias de sinalização de RAS estão aumentadas em células iniciadoras de tumor (CITs), que são definidas como células autorrenováveis capazes de iniciar a formação tumoral, sustentar o crescimento tumoral e promover a disseminação tumoral. Entretanto, terapias direcionadas a RAS não foram efetivas até hoje e a identificação de alvos de KRAS que contribuam para o fenótipo oncogênico é necessária. Como a quinase Aurora A (AURKA) já foi implicada, tanto na oncogênese induzida por KRAS, quanto em promover a função das CITs, n

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2

Schlitter, Anne-Marie [Verfasser]. "CD57high neuroblastoma cells have characteristics of tumor-initiating cells / Anne-Marie Schlitter." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1030045453/34.

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3

Chau, Wing-ka, and 周穎嘉. "Characterization of ovarian tumor-initiating cells and mechanisms of chemoresistance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197834.

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Chemoresistance remains a major clinical obstacle to effective management of ovarian cancer. Cancer stem cells (or tumor-initiating cells, TICs) have been discovered recently, and have played a pivotal role in changing the view of cancer development; however, the molecular mechanisms by which these cells escape conventional therapies remain elusive. In this study, TICs were isolated from ovarian cancer cells as tumor spheres with specific stem properties under TIC-selective conditions. Unlike non-TICs, TICs strongly express stem cell factor (SCF) and c-Kit. Blocking SCF-c-Kit by SCF neutralizi

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4

Ishibashi, Tomoko [Verfasser], and Martin [Akademischer Betreuer] Jechlinger. "Identification and Characterization of Tumor Initiating Cells in Various Mouse Mammary Tumor Models / Tomoko Ishibashi ; Betreuer: Martin Jechlinger." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180608070/34.

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5

Maekawa, Hisatsugu. "A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells." Kyoto University, 2018. http://hdl.handle.net/2433/235985.

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6

Anderson, Angela S. "Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50812.

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Ovarian cancer is known as the "silent killer," due to its late diagnosis and frequent recurrence after initial treatment. Finding a new way to diagnose and treat ovarian cancer in conjunction with current therapies is paramount. By capitalizing on metabolic changes that occur during cancer progression, interventions can be developed. The Nobel laureate Otto Warburg is credited with discovering an altered metabolic state within cancer cells known as the Warburg effect. In the Warburg effect, cancer cells participate in an increased rate of aerobic glycolysis with an excess secretion of lac

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7

Rieger, Megan Elizabeth. "Transcription Cofactor LBH is a Direct Target of the Oncogenic WNT Pathway with an Important Role in Breast Cancer." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/659.

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Limb-Bud and Heart (LBH) is a novel key transcriptional regulator of vertebrate development. However, the molecular mechanisms upstream of LBH and its role in adult development are unknown. Here we show that in epithelial development, LBH expression is tightly controlled by Wnt signaling. LBH is transcriptionally induced by the canonical Wnt pathway, as evident by the presence of functional TCF/LEF binding sites in the LBH locus and rapid beta-catenin-dependent upregulation of endogenous LBH by Wnt3a. In contrast, LBH induction by Wnt/beta-catenin signaling is inhibited by Wnt7a, which in

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8

Noudomi, Seishiro. "CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor." Kyoto University, 2016. http://hdl.handle.net/2433/217140.

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9

Shafiee, Hadi. "Marker-Free Isolation and Enrichment of Rare Cell Types Including Tumor Initiating Cells through Contactless Dielectrophoresis." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77262.

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Microfluidics has found numerous applications ranging from the life sciences industries for pharmaceuticals and biomedicine (drug design, delivery and detection, diagnostic devices) to industrial applications of combinational synthesis (such as rapid analysis and high throughput screening). Among all these, one of the intriguing exploitation of microfluidics or micro total analysis systems (µTAS) is the separation of circulating tumor cells (CTCs) from body fluids. Cancer cells spread from the initial site of a tumor by first invading the surrounding tissue, then by entering the blood or lymph

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10

Ramm, Paul [Verfasser], and Hans Robert [Akademischer Betreuer] Kalbitzer. "High field 1H-NMR spectroscopy on cell suspensions of neural progenitor cells and brain tumor-initiating cells / Paul Ramm. Betreuer: Hans Robert Kalbitzer." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1023398796/34.

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11

Wagner, Steve [Verfasser], and Andreas [Akademischer Betreuer] Trumpp. "Identification of Tumor Initiating Cells in a Patient-Matched Model of Serous Ovarian Carcinoma / Steve Wagner ; Betreuer: Andreas Trumpp." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177382660/34.

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12

Waskow, Claudia, Bonin Malte von, Martin Wermke, et al. "In Vivo Expansion of Co-Transplanted T Cells Impacts on Tumor Re-Initiating Activity of Human Acute Myeloid Leukemia in NSG Mice." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-191633.

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Human cells from acute myeloid leukemia (AML) patients are frequently transplanted into immune-compromised mouse strains to provide an in vivo environment for studies on the biology of the disease. Since frequencies of leukemia re-initiating cells are low and a unique cell surface phenotype that includes all tumor re-initiating activity remains unknown, the underlying mechanisms leading to limitations in the xenotransplantation assay need to be understood and overcome to obtain robust engraftment of AML-containing samples. We report here that in the NSG xenotransplantation assay, the large maj

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13

Waskow, Claudia, Bonin Malte von, Martin Wermke, et al. "In Vivo Expansion of Co-Transplanted T Cells Impacts on Tumor Re-Initiating Activity of Human Acute Myeloid Leukemia in NSG Mice." Public Library of Science, 2013. https://tud.qucosa.de/id/qucosa%3A28097.

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Human cells from acute myeloid leukemia (AML) patients are frequently transplanted into immune-compromised mouse strains to provide an in vivo environment for studies on the biology of the disease. Since frequencies of leukemia re-initiating cells are low and a unique cell surface phenotype that includes all tumor re-initiating activity remains unknown, the underlying mechanisms leading to limitations in the xenotransplantation assay need to be understood and overcome to obtain robust engraftment of AML-containing samples. We report here that in the NSG xenotransplantation assay, the large maj

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14

Lobba, Aline Ramos Maia. "Presença de marcadores de células-tronco em linhagens celulares humanas de câncer de mama: possível valor em diagnóstico, prognóstico e terapía." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-30092014-134216/.

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O câncer de mama é a doença maligna que mais acomete as mulheres no mundo. Apesar dos inúmeros tratamentos, o óbito se deve principalmente à doença metastática que pode se desenvolver a partir do tumor primário. Esta progressão tumoral decorre da dificuldade de se estabelecer um prognóstico mais preciso. Atualmente, a teoria de células iniciadoras de tumor vem sendo estudada para tentar explicar a biologia do câncer e descrever novos alvos para prognósticos e terapias. O carcinoma mamário foi o primeiro tumor sólido para o qual foi identificada uma subpopulação celular, definida como CD44+/CD2

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15

Zickgraf, Franziska Maria [Verfasser], and Andreas [Akademischer Betreuer] Trumpp. "SPDEF is a mediator of tumorigenicity in SSEA1- tumor-initiating cells in high grade serous ovarian cancer / Franziska Maria Zickgraf ; Betreuer: Andreas Trumpp." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1230067167/34.

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16

Anders, Lisa Mae. "Lab on a chip rare cell isolation platform with dielectrophoretic smart sample focusing, automated whole cell tracking analysis script, and a bioinspired on-chip electroactive polymer micropump." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/49614.

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Dielectrophoresis (DEP), an electrokinetic force, is the motion of a polarizable particle in a non-uniform electric field. Contactless DEP (cDEP) is a recently developed cell sorting and isolation technique that uses the DEP force by capacitavely coupling the electrodes across the channel. The cDEP platform sorts cells based on intrinsic biophysical properties, is inexpensive, maintains a sterile environment by using disposable chips, is a rapid process with minimal sample preparation, and allows for immediate downstream recovery. This platform is highly competitive compared to other cell sort

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17

Raghunath, Shobana. "Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77985.

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Prostate cancer (CaP) is the second leading cause of cancer related deaths in men in the United States. Currently, androgen depletion is an essential strategy for CaP combined with surgery, chemotherapy and radiation. Hormone independent cancer stem cells escaping conventional therapy present a major therapeutic challenge. The available treatment regimens for hormone resistant CaP are only palliative and marginally increase survival. Therefore, novel strategies to eradicate CaP including stem cells are imperative. Oncolytic virus (OV) therapy is a novel approach that overcomes the limitations

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18

Rodrigues, Felipe Silva. "Explorando a quinase IKK como um alvo terapêutico para células iniciadoras de tumor pulmonares induzidas pelo oncogene KRAS." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-26112018-080111/.

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As alterações genéticas mais frequentes em câncer de pulmão são mutações pontuais que ativam o oncogene KRAS. Embora estas mutações estejam causalmente relacionadas à oncogênese, até hoje diferentes abordagens para inibir as proteínas RAS diretamente não obtiveram sucesso. Portanto, para que melhores alvos terapêuticos para o câncer de pulmão se tornem disponíveis é necessário identificar os mecanismos moleculares ativados por KRAS que estão diretamente envolvidos com a aquisição de propriedades malignas importantes, como o desenvolvimento e a manutenção de um fenótipo tronco-tumoral pelas cél

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19

Söhngen, Eric [Verfasser], Jürgen [Akademischer Betreuer] Schlegel, and Bernhard [Akademischer Betreuer] Meyer. "Regulation of tumor initiating cells in glioblastoma multiforme. The role of Aldehyde Dehydrogenase 1 and cellular hypoxia. / Eric Mathias Söhngen. Gutachter: Bernhard Meyer ; Jürgen Schlegel. Betreuer: Jürgen Schlegel." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1066363633/34.

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20

Grillet, Fanny. "Identification et caractérisation des cellules tumorales circulantes dans le cancer colorectal." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONT3510.

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La présence de métastases est un facteur de mauvais pronostic dans les cancers solides et une meilleure compréhension de la dissémination tumorale est nécessaire afin d'améliorer la prise en charge de ces formes avancées. Les cellules tumorales circulantes (CTC) représentent un intérêt majeur dans la pathologie tumorale, d'une part sur le plan clinique en tant que marqueur prédictif et pronostique et d'autre part sur le plan de la compréhension des mécanismes impliqués dans la formation des métastases. Les CTC sont rares et hétérogènes et restent mal caractérisées, et ce, particulièrement dans

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21

Sidot, Emmanuelle. "Rôle des cellules tuft dans l'homéostasie et les cancers intestinaux." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT057.

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Au cours de ma thèse, je me suis intéressée à une population cellulaire rare et peu étudiée de l’épithélium intestinal ; les cellules tuft. La fonction de ces cellules fut longtemps débattue dans la littérature, jusqu’à ce que nous découvrions leur fonction dans l’initiation de la réponse immune de type II en réponse à une infection parasitaire. De manière intéressante, ces cellules sont présentes de manière massive et transitoire au sein des lésions adénomateuses précoces et certains groupes ont suggéré l’implication de ces cellules en tant que cellules souches tumorales. Les principaux objec

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22

Paula, Gabriela Moura de. "O PAPEL PROGNÓSTICO DAS CÉLULAS INICIADORAS TUMORAIS (CIT) NO CÂNCER DE MAMA." Pontifícia Universidade Católica de Goiás, 2014. http://localhost:8080/tede/handle/tede/2389.

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Made available in DSpace on 2016-08-10T10:38:56Z (GMT). No. of bitstreams: 1 GABRIELA MOURA DE PAULA.pdf: 7198154 bytes, checksum: f6f3fcaaba289c4b737ab5cfc3d5363a (MD5) Previous issue date: 2014-08-29<br>Breast cancer is the second most common cancer in the world. It is a complex and heterogeneous disease with diverse clinical features, cellular origin, histological types, mutations, prognosis and therapeutic possibilities. A subpopulation of cells with the ability of self-renewing, increased proliferation and resistance to chemotherapy has been described in breast cancer, named tumor-initi

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23

Xavier, Pedro Luiz Porfírio. "Caracterização de modelo in vitro de células iniciadoras tumorais oriundas de neoplasias mamárias caninas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/74/74135/tde-13092016-091747/.

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As neoplasias mamárias apresentam um grande desafio tanto para a medicina humana, quanto para a medicina veterinária. Esses tumores apresentam ampla heterogeneidade intertumoral e intratumoral, dificultando assim a busca por tratamentos eficazes. Recentemente, pesquisadores tem voltado sua atenção para uma população de células que apresentam características muito semelhantes as células-tronco. São as chamadas células iniciadoras de tumores (CITs). Estas são descritas como as principais responsáveis por falhas nas quimioterapias e no surgimento de recidivas tumorais, devido ao seu potencial tum

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24

Babahosseini, Hesam. "Single Cell Biomechanical Phenotyping using Microfluidics and Nanotechnology." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/64502.

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Cancer progression is accompanied with alterations in the cell biomechanical phenotype, including changes in cell structure, morphology, and responses to microenvironmental stress. These alterations result in an increased deformability of transformed cells and reduced resistance to mechanical stimuli, enabling motility and invasion. Therefore, single cell biomechanical properties could be served as a powerful label-free biomarker for effective characterization and early detection of single cancer cells. Advances and innovations in microsystems and nanotechnology have facilitated interrogation

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25

Wu, Colleen. "Tumor Initiating Cells in Mesenchymal Neoplasms." Thesis, 2010. http://hdl.handle.net/1807/24916.

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Despite the clonal origins of tumors, the majority of neoplasms are composed of a heterogeneous population of cells. The origins of this phenotype these cells have the potential to get can be associated with cancer stem cells or tumor initiating cells have the potential to self-renew and to differentiate giving rise to all cell types compromising a heterogeneous malignancy. These cells are clinically important as they preferentially give rise to tumors and are therefore hypothesized to account for the longevity and recurrence of neoplastic lesions. Cancer stem cells have been identified from a

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26

Tseng, Ju-Yu, and 曾如玉. "Dynamic changes and regulation of circulating tumor cells and circulating tumor initiating cells that govern the metastasis of colorectal cancer." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/75675844270518978685.

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博士<br>國立陽明大學<br>微生物及免疫學研究所<br>102<br>Despite the growing public awareness and recent progress in multimodality therapy to the colorectal cancer (CRC), CRC still ranks high on the list of the most common and deadly cancers in worldwide. The cause of CRC mortality is due mainly to the occurrence of distant metastasis, upon which the circulating tumors cells (CTCs) and/or circulating tumor initiating cells (cTICs), are thought to play an active role. Using epithelium-specific antigen (ESA) and CD133 as the surface markers to examine the presence and to quantify CTCs and cTICs, we found that CTCs

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LIAO, YU-PING, and 廖育萍. "DNA Methylation Signatures of Ovarian Tumor-Initiating Cells: Clinical Implication and Mechanistic Insights." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/vn76mk.

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博士<br>國防醫學院<br>生命科學研究所<br>102<br>DNA methylation contributes to tumor formation, development and metastasis. Epigenetic dysregulation of stem cells is thought to predispose to malignant development. The clinical significance of DNA methylation in ovarian tumor-initiating cells (OTICs) remains unexplored. We analyzed the methylomic profiles of OTICs (CP70sps) and their derived progeny using a human methylation array. qRT–PCR, quantitative methylation-specific PCR (qMSP) and pyrosequencing were used to verify gene expression and DNA methylation in cancer cell lines. The methylation status of gen

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28

Gu, Sing-Yi, and 古幸宜. "The study for the mechanism and biomarkers expression of pulmonary stem/progenitor cells becoming tumor initiating cells under malignant transformation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/00070778651905939967.

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博士<br>國立臺灣大學<br>毒理學研究所<br>104<br>Lung cancer is the leading cause of cancer-related mortality worldwide. The overall 5-year survival rate is less than 14% and most cases are diagnosed in the late stages of the disease, which tend to exhibit chemotherapy resistance, tumor recurrence, and metastasis, resulting in poor prognoses. A number of factors may increase the risk of lung cancer, such as smoking, radon exposure, and asbestos inhalation. The lung is a highly complex organ comprised of a diversity of cell types. Recent studies suggest that stem/progenitor cells are susceptible to tumorigenic

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Ke, Chien-Chih, and 柯建志. "Study of CD133-expressing thyroid cancer stem cells in I-131 therapy and tumor initiating ability modulated by mesenchymal stromal cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/56826154838156384397.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>101<br>Cancer stem cells, or called tumor initiating cells, are proposed as a population within the bulk tumor which is capable of self-renewal, differentiation and driving tumorigenesis. Cancer stem cells are reported to be more drug- and radio-resistant and contribute to treatment resistance and relapse following therapy. For thyroid cancer, with surgical thyroidectomy followed by I-131 ablation, the overall 10-year survival can reach 90%. Despite the relatively good prognosis, recurrent or metastatic thyroid cancer is not rare. I-131 ablation of remnant or I-131 t

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30

Diamandis, Phedias. "Chemical Genetic Interrogation of Neural Stem Cells: Phenotype and Function of Neurotransmitter Pathways in Normal and Brain Tumor Initiating Neural Precursor Cells." Thesis, 2010. http://hdl.handle.net/1807/24738.

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The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain brings promise for the treatment of neurological diseases and has yielded new insight into brain cancer. The complete repertoire of signaling pathways that governs these cells however remains largely uncharacterized. This thesis describes how chemical genetic approaches can be used to probe and better define the operational circuitry of the NSC. I describe the development of a small molecule chemical genetic screen of NSCs that uncovered an unappreciated precursor role of a number of neurotransm

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31

Tan, Kee-Koon, and 陳其坤. "Identification of differentially expressed proteins in Head and Neck Cancer-Tumor Initiating Cells through 18O labeling-based Comparative Proteomic Analyses." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/48488418467086964651.

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碩士<br>國立陽明大學<br>口腔生物研究所<br>99<br>Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and is responsible for about 640,000 new cases each year worldwide. Clinically, a small subpopulation called cancer stem cells (CSCs) or cancer-tumor initiating cells (TICs) has been proposed to play a role in resistance to cancer therapies such as radiotherapy and chemotherapy. Accumulating evidence suggests that TICs, including those of head and neck cancers (HN-TICs), may have contributed to various processes in carcinogenesis, such as tumor initiation, maintenance and metastasis.

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Xiong, Ailian. "Targeting triple negative human breast cancer with omega-3 docosahexaenoic acid (DHA) and tocotrienol." 2013. http://hdl.handle.net/2152/21529.

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Triple negative breast cancers (TNBCs) account for ~15-20% of human breast cancers in Western countries. TNBCs are associated with poor prognosis and a low five year survival rate due, in part, to high rates of tumor recurrence, multi-drug resistance, metastasis, and therapeutic toxicity. Tumor initiating cells (TICs) or cancer stem cells (CSCs) are proposed to be responsible for the origin and maintenance of tumors as well as cancer recurrence, metastasis and drug resistance. Nutritionally-based low- to non-toxic therapeutic nutrients that eliminate both bulk tumor cells (non-TICs) and TICs h

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邱宇凡. "The Effect of Secreted Frizzled-related Protein 1 and 3 on the Wnt Signaling in Modulating Stemness and Tumor-initiating Abilities of Cancer Cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/29996707629186879079.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>101<br>Based on the results of our study, sFRP proteins have an association with Wnt3a through cysteine-rich domain (CRD) which is located at the N terminus; while the C terminus [netrin-related (NTR) domain] associates with β-catenin. The result derived from Luciferase reporter assay proves that overexpression full-length sFRP1 can apparently inhibit the level of TopFlash reporter activities to be almost as low as the basal level. In addition, the deletion mutants, the N and C terminus of sFRP1, also inhibit activities of TopFlash reporter. In the sFRP3-overexpre

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Cournoyer, Sonia. "Analyse génotypique des cellules initiatrices de tumeurs exprimant CD133 dans le neuroblastome." Thèse, 2012. http://hdl.handle.net/1866/6998.

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Le neuroblastome (NB) est la tumeur solide extracranienne la plus fréquente et mortelle chez les jeunes enfants. Il se caractérise par une résistance à la chimiothérapie possiblement en partie dû à la présence de cellules initiatrices de tumeurs (TICs). Des études ont mis en évidence le rôle de CD133 comme un marqueur des TICs dans divers types de cancers. Les buts de notre travail étaient d’abord de démontrer les vertus de TICs des cellules exprimant CD133 et ensuite, en utilisant une analyse globale du génome avec des polymorphismes nucléotidiques simples (SNPs), d’effectuer une analyse diff

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Rippl, Marina. "Zytogenetische Charakterisierung der Glioblastomzelllinie G112 in Bezug auf tumorstammzellähnliche Eigenschaften und Strahlentherapie." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-000D-F043-4.

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Moineau-Vallée, Karine. "La glycine décarboxylase désensibilise les cellules initiatrices de tumeur à la metformine." Thèse, 2015. http://hdl.handle.net/1866/13129.

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Le cancer du pancréas est l’un des plus chimiorésistants, avec un taux de survie sur 5 ans inférieur à 5%. La chimiorésistance pourrait être due à la présence de cellules initiatrices de tumeur (TICs), une petite sous-population des cellules tumorales possédant la capacité de régénérer une nouvelle tumeur. Il a été démontré que la metformine cible les TICs par un mécanisme non élucidé. Il est connu que la metformine affecte le métabolisme du carbone. Il a également été démontré que le métabolisme du carbone, plus précisément la glycine décarboxylase (GLDC), est à la fois nécessaire et suffisan

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