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Dissertations / Theses on the topic 'Tumor necrosis factor'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Björnberg, Flemming. "Processing of TNF-receptors to soluble receptor forms in myeloid cells." Lund : Dept. of Hematology, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39176479.html.

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2

Engelberts, Ingeborg. "Tumor necrosis factor during sepsis king of cytokines? /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=6955.

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3

Krugten, Michiel Volkert van. "Tumor necrosis factor gene polymorphisms and rheumatic diseases /." Leiden, 2003. http://catalogue.bnf.fr/ark:/12148/cb40223074h.

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4

Oukacha, Khadija. "Perturbation chimique du transport de Tumor Necrosis Factor." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS067.

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Alors qu'il est essentiel pour lutter contre les agents pathogènes, TNF (Tumor Necrosis factor) secrété́ en excès devient nocif pour l'organisme comme dans le cas de maladies inflammatoires chroniques (polyarthrite rhumatoïde ou maladie de Crohn). Les thérapies actuelles sont basées sur des injections récurrentes d'anti-TNF contre lesquelles 30% des patients développent une résistance. Il existe donc un fort besoin de composés chimiques réduisant la sécrétion de TNF. Nous avons exploité la diversité́ des voies de sécrétion dépendantes de l’appareil de Golgi pour identifier des molécules inhiba

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5

Watts, Alan D. "The biological role of transmembrane tumour necrosis factor [alpha]." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27668.

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Tumour necrosis factor (TNF) exists in two physiological forms. One is a soluble polypeptide of 17 kDa, and the other a type II integral membrane protein of 26 kDa designated transmembrane TNF. Soluble TNF is derived from the transmembrane form by proteolytic processing. The soluble TNF molecule exerts potent cytotoxic activity against certain types of cancer cells, and plays a critical role in the functioning of the immune and inflammatory system. The transmembrane TNF molecule shares many of the properties of the soluble form in vitro, but its function in the immune system is not as c

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6

Langton, Amy Jean. "The role of TRUSS in TNFα-TNFRI signalling : implications for inflammatory lung diseases". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608019.

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7

Atkinson, Yvelle Hope. "Regulation of neutrophil functions by tumor necrosis factor-alpha /." Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09pha878.pdf.

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8

Bond, Arden Lenore. "The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-[alpha] /." This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-05042010-020132/.

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9

Tan, Ern Yu. "Loss of protein folding gene expression in human tumors." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670106.

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10

Han, Jiahuai. "Study of the regulation of cachectin/tumor necrosis factor expression." Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213139.

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11

Hel, Zdenek. "Posttranscriptional regulation of tumor necrosis factor-Ã production in macrophages." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0010/NQ36980.pdf.

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12

Mustapha, Shareef. "Signaling pathways of tumor necrosis factor Ã in ventricular myocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ41751.pdf.

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13

Hel, Zdenĕk. "Posttranscriptional regulation of tumor necrosis factor-a production in macrophages." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34642.

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The production of tumor necrosis factor-alpha (TNF-alpha), a key cytokine regulator of an early immune response and a central mediator of the deleterious effects of systemic inflammatory response syndrome, is regulated at both the transcriptional and posttranscriptional level. The 3' -untranslated region (3'-UTR) of TNF-alpha mRNA contains sequences that confer its translational repression in quiescent cells and are responsible for the induction of TNF-alpha production following macrophage contact with bacterial lipopolysaccharide, live bacteria, or viruses.<br>We demonstrate that two distinct

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14

Koelen, Jorien Anne. "Arming ColoAd1 with tumor necrosis factor α and lymphotoxin α". Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:bfc9d84f-2677-45db-8705-791219446348.

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Colon and rectum cancers (CRCs) are the third most prevalent cause of cancer-related mortality. Advanced metastatic CRC has a very poor prognosis; indicating the need for improved therapy. Tumour necrosis factor (TNF) can induce an immune response against tumours and cause cell death of the tumour-associated vasculature. However, dose-limiting toxicity occurs with systemic TNF treatment. In order to assess the effects of expressing TNF and lymphotoxin a (LTA) locally in the tumour microenvironment, a syngeneic CT26 CRC model expressing soluble (sm), full length (fm) or membranebound (mbm) muri

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15

Steffen, Brian. "Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6001.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>"December 2007" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.

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16

Debets, Jacobus Maria Hubert. "Studies on tumor necrosis factor endogenous mediators of sepsis and cachexia /." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5468.

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17

Karimi, Mahdad. "Functional analysis of the -308G/A polymorphism in the tumour necrosis factor promoter." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0140.

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[Truncated abstract] Tumor Necrosis Factor (TNF) is a potent pro-inflammatory cytokine involved in a range of biological functions including the differentiation, proliferation and survival of many cell types. The TNF gene lies in the class III region of the major histocompatibility complex (MHC), approximately 250 Kbp centromeric of the HLA-B locus and 850 Kbp telomeric of HLA-DR. Due to the genomic location and biological relevance of TNF, it is thought that genetic heterogeneity at this locus may be associated with autoimmune and infectious diseases. A G-to-A single nucleotide polymorphism (

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18

Zwaveling, Jan Harm. "Systemic side effects of isolated limb perfusion with tumor necrosis factor alpha." [S.l. : [Groningen] : s.n.] ; [University Library Groningen] [Host], 1997. http://irs.ub.rug.nl/ppn/15723665X.

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19

Babu, Kesavan Suresh. "The role of tumor necrosis factor alpha (TNF-Î±) in asthma." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439378.

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20

Di, Marco Sergio. "Posttranscrip[t]ional regulation of tumor necrosis factor production in macrophages." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37648.

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Tumor necrosis factor alpha (TNFalpha) is a key proinflammatory cytokine which is produced primarily by macrophages. Although this cytokine is very beneficial to the host when released in small amounts or in localized fashion, abnormally high levels of TNFalpha can however be very detrimental. The biological effects of this cyokine is thus dependent on its timing, location and extent of release. In recent years major interest has been placed on the AU rich elements (ARE) present in the 3' untranslated region of the TNFalpha mRNA as it plays a pivitol role in the posttranscriptional control of

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21

Cantwell, Mark J. "The Tumor necrosis factor family : roles in disease pathology and therapy /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9824693.

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22

Yang, Junbao. "Genetic engineering of a fusion protein possessing anti-tumor Fv and tumor necrosis factor alpha." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0030/NQ63940.pdf.

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23

Yadav, Ajay Kumar. "Relationship between human hemoglobin and tumor necrosis factor a : immunochemistry and bioactivity studies." Thesis, JAMIA HAMDARD (IIAMDARD UNIVERSITY), 2002. http://hdl.handle.net/123456789/1468.

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24

Hurst, Liam Andrew. "The role of tumour necrosis factor alpha in pulmonary arterial hypertension." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648471.

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25

Mallet, Dominique. "Interet du tumor necrosis factor alpha dans le suivi precoce des transplantations renales." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20913.

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26

Sutherland, Andrew Peter Robert St Vincents Clinical School UNSW. "BAFF regulation of peripheral T cell responses." Awarded by:University of New South Wales. St Vincents Clinical School, 2005. http://handle.unsw.edu.au/1959.4/22788.

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The activation and effector function of CD4+ T cells are critical points of regulation during an antigen specific T cell response. Dysregulation of these processes can lead to the development of human diseases, encompassing both immunodeficiency and autoimmunity. Members of the TNF superfamily have recently emerged as important regulators of T cell responses, with their overexpression causing autoimmune inflammation in animal models. As overproduction of the novel TNF superfamily ligand BAFF is associated with several autoimmune conditions, we sought to examine the potential role of BAFF as a

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27

Ano, Monfils Nadhia. "Etude de la production et des caracteristiques biologiques du tnf alpha humain produit a partir d'une lignee cellulaire humaine." Lillle 2, 1993. http://www.theses.fr/1993LIL2P256.

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28

Li, Rui Xin. "Scutellarin inhibits TNF-induced proliferative expansion of Tregs by blocking TNF-TNFR2 interactions." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952140.

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29

Laureau, Serge. "Le tumor necrosis factor (tnf) en dermatologie : etude de la production de tnf par les monocytes circulants au cours du psoriasis : revue de la litterature." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20817.

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30

劉耀南 and Yiu-nam Lau. "Interferons and tumour necrosis factor in chronic hepatitis B virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981446.

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31

Lau, Yiu-nam. "Interferons and tumour necrosis factor in chronic hepatitis B virus infection." Hong Kong : University of Hong Kong, 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2158879X.

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32

Kam, Siu-kei Christy. "The role of TGF-[beta] signaling in the initiation of TNF-[beta] expression in human PBMC derived macrophages." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38746049.

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33

Kam, Siu-kei Christy, та 甘笑琪. "The role of TGF-{221} signaling in the initiation of TNF-α expression in human PBMC derived macrophages". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38746049.

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34

Woo, Andrew Jonghan. "Characterization and identification of transcription factors that bind to the tumor necrosis factor -308 polymorphism." University of Western Australia. School of Biomedical and Chemical Sciences, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0044.

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[Formulae and special characters can only be approximated. Please see the pdf version of this abstract for an accurate reproduction.] Tumor necrosis factor (TNF) is a pleiotropic cytokine that mediates a long list of immunological and pathophysiological processes. TNF is produced by a wide variety of cells including immune and non-immune cells, however in most cell types TNF is not expressed prior to stimulation. The function of TNF is mediated via its trimeric domain by binding to TNF receptors that are found on most types of cells, especially of the haematopoietic systems, hence transpiring

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35

Youseff, Brian. "The Role of Tumor Necrosis Factor Receptor-Associated Factor 6 in Tick-Borne Flavivirus Infection." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco155691388498993.

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36

Emmanuel, Catherine. "Apoptotic And Morphometric Synergies Between Tumour Necrosis Factor-A And Transforming Growth Factor-B1 For Human Endothelial Cells." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/4864.

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37

Pistilli, Emidio E. "The extrinsic apoptotic pathway in aged skeletal muscle roles of tumor necrosis factor-[alpha] and interleukin-15 /." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4912.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains x, 189 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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38

Lampa, Jon. "Studies of pharmacological interventions and pathogenesis of rheumatoid arthritis /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-372-4/.

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39

Hakim, Akhlaq Waheed. "Tumor necrosis factor alpha and non-inflammatory sensitization of masseter muscle nociceptors." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34182.

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Behavioral evidence in rats indicates that injection of tumor necrosis factor alpha (TNFalpha into skeletal muscle results in a prolonged mechanical sensitization without gross inflammation. The present series of studies were conducted to test the idea that injection of TNFalpha causes mechanical sensitization of skeletal muscle through a peripheral mechanism that involves lowering of the mechanical threshold (MT) of muscle nociceptors without inflammation. In- vivo extracellular electrophysiological recording was used to assess the effect of TNFalpha (1 or 0.1microgram) and other drugs on th

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40

Vasconcelos, Daniel Fernando Pereira. "Analise do polimorfismo genetico do fator de necrose tumoral Beta (+252 A/G) em pacientes com periodontite cronica." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290042.

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Orientadores: Silvana Pereira Barros, Sergio Roberto Peres Line<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-04T03:46:37Z (GMT). No. of bitstreams: 1 Vasconcelos_DanielFernandoPereira_M.pdf: 718453 bytes, checksum: 33e7ea7787a27dcce6c7a1cac2b7b5ed (MD5) Previous issue date: 2005<br>Resumo: A doença periodontal (DP) é causada por interações entre fatores do hospedeiro, microrganismos específicos patogênicos e o sistema imunológico. TNF-b é um imunoregulador multifuncional que está relacionado com a

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41

Rogers, Gabrielle Marie. "Tumor necrosis factor- alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4712.

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Thesis (M.S.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains vi, 45 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 40-45).

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42

Zhang, Min. "The role of B cell activating factor in B cell development and autoimmunity." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37659807.

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43

Vaughan-Scott, Tarquin. "Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease." Diss., University of Pretoria, 2002. http://hdl.handle.net/2263/29287.

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Please read the abstract in the section 00front of this document<br>Canine babesiosis, caused by the tick-borne protozoan Babesia canis rossi, is an economically important and potentially fatal disease of dogs in South Africa. The host's response to many infectious diseases is mediated (at least in part) by intercellular messengers called cytokines. One of the most important cytokines released is tumour necrosis factor (TNF). A study was designed to measure serum concentrations of TNF in dogs naturally infected with canine babesiosis and to relate TNF concentrations to clinical severity,

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44

Pedro, Renato Nardi. "Uso da nanopartícula de ouro ligada a moléculas de fator alfa de necrose tumoral como adjuvante da termoablação por radiofrequência de tumores renais = modelo animal experimental." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310676.

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Orientadores: Marcelo Lopes de Lima, Nelson Rodrigues Netto Junior<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-17T00:02:35Z (GMT). No. of bitstreams: 1 Pedro_RenatoNardi_D.pdf: 3805668 bytes, checksum: 8b1ea901163cf75ede5f727e7f455e0c (MD5) Previous issue date: 2010<br>Resumo: O tratamento definitivo das massas renais malignas é primordialmente cirúrgico, sendo a nefrectomia radical eleita por muitos anos a cirurgia padrão para o tratamento do câncer renal localizado. Entretanto, com o envelhecimento populacion

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45

Catrina, Anca Irinel. "Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-102-4/.

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46

Liddil, James Duncan 1960. "Mechanisms of the cytotoxic actions of tumor necrosis factor (TNF) in cultured cancer cells." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276602.

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Tumor necrosis factor's (TNF) cytotoxic mechanism of action was examined using cultured cancer cell lines. TNF demonstrated cytolytic and cytostatic effects on L929 fibrosarcoma and MCF-7 adenocarcinoma cells. TNF failed to show any specific effects on RNA, DNA or protein synthesis or ATP content in tumor cells in vitro. It did not cause DNA single strand breaks. Decreased cellular levels of reduced thiols did not predict sensitivity to the cytotoxic effects of TNF. Depletion of cellular glutathione failed to increase the sensitivity of TNF-sensitive or resistant cells. However, various non-sp

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47

Ayub, Qasim. "Prevention of endotoxic shock in mice using anti-tumor necrosis factor-alpha monoclonal antibody." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798464/.

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48

Howat, Sarah Lamont Telfer. "TSG6 : expression and influence on the stability of the extracellular matrix in joint tissues." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326100.

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49

Neville, Matt J. "Characterisation of the genomic region around the TNF locus within the human major histocompatibility complex in the chromosome band 6p21.3." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:1fcb0019-0b54-418a-a44c-b1b4a7d5a51e.

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It is becoming increasingly apparent that many of the genes in the class III region of the human Major Histocompatibility Complex encode proteins involved in the immune and inflammatory responses. Furthermore, genetic studies have indicated that genes within the class III region, particularly the telomeric segment containing the TNF gene, could contribute to susceptibility to diseases of immune-related aetiology. To further characterise this region and to identify candidate disease susceptibility genes, two overlapping cosmids, TN62 and TN82, covering an ~82kb segment of DNA around the TNF gen

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50

BOTTIER, DANIEL. "Interet clinique de l'immunodosage enzymatique de l'il-1 et du tnf dans les liquides biologiques." Nice, 1991. http://www.theses.fr/1991NICE6830.

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