Academic literature on the topic 'Tumor pathologies'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Tumor pathologies.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Tumor pathologies"
1
Mende, Klaus C., Theresa Krätzig, Malte Mohme, Manfred Westphal, and Sven O. Eicker. "Keyhole approaches to intradural pathologies." Neurosurgical Focus 43, no. 2 (2017): E5. http://dx.doi.org/10.3171/2017.5.focus17198.
Full textAbstract:
OBJECTIVESpinal tumors account for 2%–4% of all tumors of the central nervous system and can be intramedullary, intradural extramedullary, or extradural. In the past, wide approaches were used to obtain safe access to these tumors, as complete resection is the goal in treating most tumor entities. To reduce surgical complications due to large skin incisions and destabilizing laminectomies, minimally invasive approaches were established. In this study, the authors share their experience with mini-open approaches to intradural tumor pathologies.METHODSThe authors retrospectively reviewed cases involving patients with intramedullary and intradural extramedullary lesions treated between 2009 and 2016. They present their surgical mini-open approach to the spinal cord as well as unique characteristics, key steps, and postsurgical complications for specific tumor subgroups (meningioma, neuroma, and intramedullary tumors).RESULTSA total of 245 intradural tumors were surgically treated during the study period. Of these lesions, 151 were intradural extramedullary meningiomas (n = 79) or neuromas (n = 72). Nine (12.5%) of the neuromas were dumbbell neuromas. Ninety-four tumors were intramedullary. The mean age of the patients was 51.4 years, and 53.9% were female. The mean duration of follow-up was 46.0 months.All meningiomas and neuromas could be resected using a mini-open keyhole approach, but only 5.3% of the intramedullary lesions could be accessed using this technique. Of the 94 patients with intramedullary tumors, 76.6% required a laminotomy, 7.4% required a hemilaminectomy, and 10.6% required a 2-level laminectomy. Only 2 of the patients with intramedullary tumors needed stabilization for progressive cervical kyphosis during follow-up. None of the other patients developed spinal instability after undergoing surgery via the mini-open (keyhole/interlaminar) approach. There were significantly more surgery-associated complications in the large exposure group than in the patients treated with the mini-open approach (19.1% vs 9.6%, p < 0.01).CONCLUSIONSIntradural extramedullary and in selected cases intramedullary pathologies may safely be resected using a mini-open interlaminar approach. Avoiding laminectomy, laminotomy, and even hemilaminectomy preserves spinal stability and significantly reduces comorbidities, while still allowing for complete resection of these tumors.
2
Parra Sanabria, Erika Alexandra, and Claudia Patricia Peña Vega. "Frequency of Oral and Maxillofacial Pathologies in Patients from 0 to 18 Years in the Fundación Hospital de la Misericordia Bogotá (Colombia), during the Period 2006-2014." Universitas Médica 59, no. 4 (2018): 1–9. http://dx.doi.org/10.11144/javeriana.umed59-4.fpom.
Full textAbstract:
Introduction: Oral pathologies that can occur in children are very diverse and require extensive knowledge to diagnose them. Objective: To describe the frequency of oral and maxillofacial pathologies that occurred in patients aged 0-18 years who attended the Fundación Hospital de la Misericordia (HOMI) in the period 2006-2014, in addition to relating the most frequent oral and maxillofacial pathologies with sociodemographic characteristics. Materials and Methods: Descriptive, cross-sectional study. The analysis of information was recorded of 277 clinical histories of the HOMI, in patients from 0 to 18 years, who were diagnosed with any of the oral and maxillofacial pathologies, divided as follows: Head/neck cystic lesions, temporomandibular joint (TMJ) lesions, infectious lesions, benign tumor, malignant tumor of head and neck, and benign odontogenic tumor. It was carried out in analysis of the sociodemographic characteristics. Results: The most frequent pathologies were infectious lesions (62.45%), followed by benign odontogenic tumors (12.99%). Conclusions: This study shows that the most frequent pathologies were infectious lesions and benign odontogenic tumors.
3
Parodi, Silvio, and Tommaso Mancuso. "A General Overview of the Process of Carcinogenesis." Tumori Journal 82, no. 4 (1996): 291–301. http://dx.doi.org/10.1177/030089169608200401.
Full textAbstract:
A general synthetic overview of the process of carcinogenesis is presented. The following points are discussed: the uniqueness of tumor disease with respect to other pathologies; tumors viewed as a pathology of the transduction system of signals that regulate the communal life of the cells of multicell organisms; the tumor as a genetic disease of somatic cells; carcinogenesis as a multistage event; the fundamental role of physiologic and pathologic rhythms of cell proliferation in the modulation of tumor incidence; mechanisms entailed in the maintenance of genome integrity; mechanisms involved in the protection of genome integrity from exogenous and endogenous causes of degradation of the genetic message.
4
Wadhwa, Vibhor, Rashmi S. Thakkar, Nicholas Maragakis, et al. "Sciatic nerve tumor and tumor-like lesions—uncommon pathologies." Skeletal Radiology 41, no. 7 (2012): 763–74. http://dx.doi.org/10.1007/s00256-012-1384-7.
Full text
5
Sımsık, Sedat, Bülent Hayri Özokutan, Haluk Ceylan, Abdullah Aydın, and Elif Güler. "Ovarian Pathologies in Childhood." European Journal of Therapeutics 16, no. 2 (2010): 1–4. http://dx.doi.org/10.58600/eurjther.2010-16-2-1239-arch.
Full textAbstract:
Ovarian diseases are not rare in childhood and some problems are encountered with in evaluation of ovarian pathologies such as existance of different terminologies, lack of pathological criteria and different types of tumor classiffications. 55 patients younger than 16 years who had ovarian disease were treated and followed up and then the results were evaluated retrospectively. Patients were seperated in 3 groups as ovarian torsions (n:21), neoplastic ovarian pathologies (n:19) and non-neoplastic ovarian pathologies (n:28). Most frequent clinical symptom was abdominal pain and most frequent clinical finding was abdominal sensitivity in all groups. 1n non-neoplastic ovarian pathology group, 21 patients were treated surgically whereas seven were treated conservatively. As the result of histopathological examinations follicular cysts (n:11), simple cysts (n:8), corpus luteum cysts (n:7), paraovarian cyst (n:1) and massive ovarian edema (n:1) were observed. 1n the neoplastic ovarian pathology group, all patients were treated surgically and 8 serous cystadenoma, 7 mature cystic teratoma, 2 dysgerminoma, 1 juvenile granulosa cell tumor, and 1 seromucinous borderline tumor were observed after histopathological examinations. 1n the ovarian torsion group, torsions were due to non- neoplastic pathology in 7 and neoplastic pathology in 6 patients. Torsions were developed without any cysts or tumor in 8 patients. Oopherectomy or salphingoopherctomy was performed in twenty patients. 1n one patient ovary was preserved as circulation turned normal after detorsion. Ovarian pathologies are not rare in childhood and should be included in the differential diagnosis of abdominal pain in girls. Extensive use of radiological studies have facilitated the diagnosis of these lesions.
6
Saymeh, M., S. Khairy, A. Moreno, J. Rabski, S. Kilty, and F. Alkherayf. "P.145 The role of 5-ALA Fluorescence-guided surgery in non-glioma pathologies." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 52, s1 (2025): S49. https://doi.org/10.1017/cjn.2025.10292.
Full textAbstract:
Background: Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) is a well-established tool for improving tumor visualization in glioma surgery. However, its applications in non-glioma pathologies remain underexplored and require further investigation. Methods: A retrospective review of patients who underwent FGS with 5-ALA between January 2022 and September 2024 was conducted to assess its utility in non-glioma tumors. Results: Among 232 FGS procedures, 13 (5.6%) involved non-glioma pathologies. We categorized our patients into three different levels: high, moderate, and no response based on intra-operative 5-ALA fluorescence visualization. Our patients showed a high 5-ALA fluorescence in 10 cases (77%), mainly in the following tumors: choroid plexus papilloma, atypical teratoid rhabdoid tumor, metastatic adenocarcinoma as well as atypical meningiomas. Moderate 5-ALA fluorescence was seen in 2 cases (15%). While no 5-ALA fluorescence was seen in one case of CNS lymphoma. 90% of procedures with high response had total resection. Conclusions: Fluorescence-guided surgery (FGS) using 5-ALA has demonstrated effectiveness in enhancing tumor visualization beyond gliomas. This retrospective review highlights the potential applications of 5-ALA in various non-glioma pathologies. These findings emphasize the need for further research to refine the use of 5-ALA FGS in diverse pathologies, optimize patient selection, and expand its utility in neurosurgical oncology.
7
Saxena, Suvinay, Drushi D. Patel, Ankur Shah, and Mrugesh Doctor. "Fat Chance for Hidden Lesions: Pictorial Review of Hoffa's Fat Pad Lesions." Indian Journal of Radiology and Imaging 31, no. 04 (2021): 961–74. http://dx.doi.org/10.1055/s-0041-1739383.
Full textAbstract:
AbstractHoffa's fat pad (HFP) is the most commonly afflicted among all the knee fat pads. Anterior knee pain is common in various pathologies of HFP, as it is richly innervated. A potpourri of the intrinsic and extrinsic pathologies and the tumors and tumor-like conditions affect HFP, and MRI remains the fundamental modality to assess them and provide a specific diagnosis.
8
Zehra, Pınar Koc, Pınar Özcan Kara Pelin, Sezer Emel, Özcan Cengiz, Yaldız Mehmet, and Görür Kemal. "Squamous cell carcinoma associated granular cell tumor with progressive FDG accumulation." International Journal of Medical Reviews and Case Reports 3, no. 11 (2019): 777–78. https://doi.org/10.5455/IJMRCR.Granular-cell-tumor-FDG-uptake.
Full textAbstract:
Granular cell tumor is a usually benign rare tumor of middle age women with variable FDG uptake patterns. The case that we presented was the first in the literature as far as we know with presentation of two different concurrent pathologies and progressive FDG uptake. Since the case was considered unresectable the patients received further chemotherapy. The patients' PET/CT results showed progression under treatment.
9
Rusda, Muhammad, Riza Rivany, Citra Lestari Hasibuan, Delfi Lutan, Dudy Aldiansyah, and Cut Adeya Adella. "IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies." Sumatera Medical Journal 2, no. 1 (2019): 47–54. http://dx.doi.org/10.32734/sumej.v2i1.719.
Full textAbstract:
To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence.
10
Topolyanskaya, S. V. "Tumor Necrosis Factor-Alpha and Age-Related Pathologies." Russian Archives of Internal Medicine 10, no. 6 (2020): 414–21. http://dx.doi.org/10.20514/2226-6704-2020-10-6-414-421.
Full textAbstract:
Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory diseases as well as in aging. The increased levels of tumor necrosis factor-α leads to the onset and progression of various diseases, to severity of frailty, to disability and mortality of elderly persons. Tumor necrosis factor-α affects different risk factors for cardiovascular diseases, contributes to the onset and progression of atherosclerosis and related pathology. This cytokine can also aggravate various metabolic disorders, mainly — insulin resistance and diabetes mellitus. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (up to osteoporosis) and sarcopenia (up to cachexia). Currently available data confirm the important role of tumor necrosis factor-α in various age-associated disorders.
Dissertations / Theses on the topic "Tumor pathologies"
1
Tommasone, Stefano. "Synthesis of calixarene derivatives active towards proteic targets involved in tumor pathologies." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2213.
Full textAbstract:
2014 - 2015<br>Over the last 30 years a growing interest has been direct toward the biomolecular recognition of calixarene derivatives and more in particular to the interaction with druggable target(s).1,2
The aim of this PhD thesis was the synthesis and the study of calixarenes that were able to interact with biomolecules involved in tumor pathologies.
One of the main topic of this work was the synthesis of calix[4]arene conjugates bearing pyrenylisoxazolidine moieties at the exo rim which could act as potential DNA intercalators. The in vitro cytotoxic activity against different human tumor cell lines was also tested.
Moreover, the biomolecular recognition abilities of designed calixarenes was studied through a chemical proteomics approach.
As calix[n]arene scaffolds are particularly suitable for the synthesis of multivalent ligands,3 the attention was also focused on the synthesis of multivalent iminosugar-calix[8]arene conjugates for the inhibition of glycosidases.
The synthesis, characterization and all the biomolecular recognition studies were herein described. [edited by author]<br>XIV n.s.
2
Barillot, Noëmie. "Nouvelles approches de machine learning pour l'analyse de données en pathologie numérique : application aux lymphomes primitifs du système nerveux central et extension à d'autres pathologies tumorales." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS278.
Full textAbstract:
Cette thèse explore l'application de nouvelles approches de machine learning (ML) pour l'analyse de données en pathologie numérique, en se concentrant sur des pathologies tumorales rares. Trois études principales sont détaillées, chacune utilisant diverses techniques de ML pour améliorer la compréhension et le traitement de ces maladies.La première étude se concentre sur les lymphomes primitifs du système nerveux central (SNC), un cancer rare du système nerveux central. L'objectif est d'analyser des lames numériques pour prédire l'évolution clinique des patients et identifier des sous-groupes moléculaires spécifiques. Cette analyse permet d'améliorer la stratification des patients, offrant l'espoir de traitements plus personnalisés. L'utilisation de techniques avancées de ML a permis d'identifier des modèles distincts d'évolution clinique et de classification moléculaire.La deuxième étude porte sur les tumeurs ovariennes liées à un syndrome neurologique paranéoplasique anti-Yo, une condition rare où des tumeurs ovariennes provoquent des symptômes neurologiques extit{via} des réponses immunitaires aberrantes. En utilisant des approches de segmentation automatique et d'analyse de texture par pathomique, cette étude a permis de classifier les tumeurs associées à une dégénérescence cérébelleuse paranéoplasique anti-Yo. Les résultats montrent une identification prometteuse de ces syndromes et des différences significatives dans l'infiltrat immunitaire, ouvrant de nouvelles avenues pour comprendre les interactions entre tumeurs et système immunitaire.La troisième étude propose une nouvelle méthode de normalisation des images de lames numériques en coloration hématoxyline-éosine (HE) basée sur le transport optimal. Cette méthode vise à améliorer la comparabilité et la qualité des images pour les tâches de classification et de segmentation. En démontrant l'intérêt de cette approche, l'étude montre comment le transport optimal peut standardiser les images de pathologie numérique, facilitant une analyse plus précise et fiable. Cette avancée technique représente un pas important vers l'intégration de méthodes de ML robustes dans la pratique clinique quotidienne.Ces études montrent le potentiel des techniques de ML pour améliorer la classification, la segmentation et l'analyse des tumeurs rares, offrant des perspectives prometteuses pour la recherche clinique et le traitement personnalisé des patients<br>This thesis explores the application of new machine learning (ML) approaches for data analysis in digital pathology, focusing on rare tumor pathologies. Three main studies are detailed, each using various ML techniques to improve the understanding and treatment of these diseases.The first study focuses on primary CNS lymphomas, a rare cancer affecting the central nervous system. The objective is to analyze digital slides of these lymphomas to predict the clinical outcomes of patients and identify specific molecular subgroups. This analysis aims to improve patient stratification and offer more personalized treatments. The use of advanced ML techniques has enabled the identification of distinct clinical progression patterns and molecular classification.The second study addresses ovarian tumors linked to anti-Yo paraneoplastic neurological syndrome, a rare condition where ovarian tumors cause neurological symptoms through aberrant immune responses. By utilizing automatic segmentation and pathomic texture analysis approaches, this study has classified tumors associated with paraneoplastic cerebellar degeneration. The results show promising identification of these syndromes and significant differences in immune infiltrates, opening new avenues for understanding interactions between tumors and the immune system.The third study proposes a new method for normalizing digital slide images in HE staining based on optimal transport. This method aims to improve the comparability and quality of images used for classification and segmentation tasks. By demonstrating the benefits of this approach, the study shows how optimal transport can help standardize digital pathology images, facilitating more precise and reliable analysis. This technical advancement represents an important step toward integrating robust ML methods into everyday clinical practice.These studies highlight the potential of ML techniques to enhance the classification, segmentation, and analysis of rare tumors, offering promising prospects for clinical research and personalized patient treatment
3
Gjorgjieva, Monika. "Identification des mécanismes moléculaires impliqués dans le développement des pathologies hépatiques et rénales dans des modèles murins de glycogénose de type 1a." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1007/document.
Full textAbstract:
La glycogénose de type I (GSDI) est une maladie génétique rare, due à une déficience en glucose-6 phosphatase (G6Pase), enzyme clé de la production endogène de glucose. En plus des hypoglycémies sévères, la perte de l'activité G6Pase conduit à l'accumulation de glycogène, mais aussi de lipides dans le foie et les reins. A long-terme, la plupart des patients développent des tumeurs hépatiques et une maladie rénale chronique (MRC).Le but de cette thèse a été de caractériser les mécanismes moléculaires impliqués dans la carcinogenèse hépatique et la MRC grâce à des modèles murins viables et uniques, avec une délétion de la G6Pase spécifiquement dans le foie ou les reins, reproduisant respectivement toutes les caractéristiques de la pathologie hépatique ou rénale.Au niveau du foie, notre étude a permis de mettre en évidence une reprogrammation métabolique « Warburg-like » très similaire à celle des cellules cancéreuses, associée à une perte des défenses cellulaires et des suppresseurs de tumeur. De plus, nous avons montré que les adénomes hépatocellulaires, se transformant ensuite en carcinomes, se développent en absence de fibrose, en accord avec l'absence d'activation des voies pro-fibrotiques. Au niveau des reins, l'étude de la MRC a mis en évidence le développement de kystes rénaux chez les souris atteintes de GSDI, observés aussi chez les patients à un stade avancé de la MRC. Finalement, une dernière étude portant sur l'activation de l'oxydation des lipides, par un traitement des souris au fénofibrate, a permis de suggérer le rôle délétère de l'accumulation des lipides dans le développement des pathologies hépatique et rénale<br>Glycogen storage disease type I (GSDI) is a rare genetic disease, due to a deficiency in glucose-6 phosphatase (G6Pase), a key enzyme in the endogenous glucose production. Besides severe hypoglycemia, the loss of G6Pase leads to the accumulation of glycogen and lipids in the liver and kidneys. On the long term, most patients develop hepatic tumors and chronic kidney disease (CKD).The goal of this thesis was to characterize the molecular mechanisms involved in hepatic carcinogenesis and CKD, thanks to viable and unique mouse models with specific deletion of G6Pase in the liver or kidneys, which exhibit all hallmarks of hepatic and renal pathologies, respectively.On a hepatic level, our study allowed us to highlight a « Warburg-like » metabolic reprogramming, very similar to what is observed in cancer cells, associated with a loss of cellular defenses and tumor suppressors. Furthermore, we showed that formation of hepatocellular adenoma, which transform later in carcinoma, occurs in the absence of liver fibrosis, due to the fact that pro-fibrotic pathways are not activated. In the kidneys, the study of CKD highlighted the development of renal cysts in mice with GSDI, as well as in the patients presenting an advanced stage of CKD. Finally, the last study on the activation of the oxidation of lipids, by treating the mice with fenofibrate, allowed us to suggest a deleterious role of lipid accumulation in the development of the hepatic and renal pathologies
4
Poenaru-Bernard, Oana. "Cytokines de la résorption et marqueurs du rémodelage dans le suivi thérapeutique de pathologies métaboliques osseuses." Paris 7, 2002. http://www.theses.fr/2002PA077154.
Full text
5
Gjorgjieva, Monika. "Identification des mécanismes moléculaires impliqués dans le développement des pathologies hépatiques et rénales dans des modèles murins de glycogénose de type 1a." Electronic Thesis or Diss., Lyon, 2018. http://www.theses.fr/2018LYSE1007.
Full textAbstract:
La glycogénose de type I (GSDI) est une maladie génétique rare, due à une déficience en glucose-6 phosphatase (G6Pase), enzyme clé de la production endogène de glucose. En plus des hypoglycémies sévères, la perte de l'activité G6Pase conduit à l'accumulation de glycogène, mais aussi de lipides dans le foie et les reins. A long-terme, la plupart des patients développent des tumeurs hépatiques et une maladie rénale chronique (MRC).Le but de cette thèse a été de caractériser les mécanismes moléculaires impliqués dans la carcinogenèse hépatique et la MRC grâce à des modèles murins viables et uniques, avec une délétion de la G6Pase spécifiquement dans le foie ou les reins, reproduisant respectivement toutes les caractéristiques de la pathologie hépatique ou rénale.Au niveau du foie, notre étude a permis de mettre en évidence une reprogrammation métabolique « Warburg-like » très similaire à celle des cellules cancéreuses, associée à une perte des défenses cellulaires et des suppresseurs de tumeur. De plus, nous avons montré que les adénomes hépatocellulaires, se transformant ensuite en carcinomes, se développent en absence de fibrose, en accord avec l'absence d'activation des voies pro-fibrotiques. Au niveau des reins, l'étude de la MRC a mis en évidence le développement de kystes rénaux chez les souris atteintes de GSDI, observés aussi chez les patients à un stade avancé de la MRC. Finalement, une dernière étude portant sur l'activation de l'oxydation des lipides, par un traitement des souris au fénofibrate, a permis de suggérer le rôle délétère de l'accumulation des lipides dans le développement des pathologies hépatique et rénale<br>Glycogen storage disease type I (GSDI) is a rare genetic disease, due to a deficiency in glucose-6 phosphatase (G6Pase), a key enzyme in the endogenous glucose production. Besides severe hypoglycemia, the loss of G6Pase leads to the accumulation of glycogen and lipids in the liver and kidneys. On the long term, most patients develop hepatic tumors and chronic kidney disease (CKD).The goal of this thesis was to characterize the molecular mechanisms involved in hepatic carcinogenesis and CKD, thanks to viable and unique mouse models with specific deletion of G6Pase in the liver or kidneys, which exhibit all hallmarks of hepatic and renal pathologies, respectively.On a hepatic level, our study allowed us to highlight a « Warburg-like » metabolic reprogramming, very similar to what is observed in cancer cells, associated with a loss of cellular defenses and tumor suppressors. Furthermore, we showed that formation of hepatocellular adenoma, which transform later in carcinoma, occurs in the absence of liver fibrosis, due to the fact that pro-fibrotic pathways are not activated. In the kidneys, the study of CKD highlighted the development of renal cysts in mice with GSDI, as well as in the patients presenting an advanced stage of CKD. Finally, the last study on the activation of the oxidation of lipids, by treating the mice with fenofibrate, allowed us to suggest a deleterious role of lipid accumulation in the development of the hepatic and renal pathologies
6
DADUCCI, Alessandro. "Advanced image-processing techniques in magnetic resonance imaging for the investigation of brain pathologies and tumour angiogenesis." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/343984.
Full textAbstract:
L'imaging a risonanza magnetica (MRI) è sempre più utilizzato in ambiente medico per la sua abilità di produrre in modo non invasivo immagini di altà qualità dell'interno del corpo umano. Sin dalla sua introduzione nei primi anni 70, techiche di acquisizione via via più complesse sono state proposte, portando l'MRI ad essere utilizzata su uno spettro di applicazioni sempre più ampio. Le tecniche più innovative, tra cui la risonanza magnetica funzionale e di diffusione, richiedono tecniche di analisi ed algoritmi di elaborazione molto complessi per estrarre informazioni utili dai dati acquisiti. Lo scopo di questa tesi è stato quello di sviluppare e ottimizzare tecniche avanzate di elaborazione per applicarle all'analisi di dati di risonanza magnetica sia in ambiente preclinico che clinico. Durante il corso di dottorato sono stato coinvolto attivamente in diversi progetti di ricerca, ed ogni volta mi sono trovato ad affrontare problematiche diverse. In questa tesi, tuttavia, saranno riportati i risultati ottenuti nei tre progetti più interessanti a cui ho preso parte.
Tali progetti avevano come obiettivo (i) l'implementazione di un protocollo sperimentale innovativo per imaging funzionale in animali da laboratorio, (ii) lo sviluppo di nuovi metodi per l'analisi di dati di Dynamic Contrast Enhanced MRI in modelli sperimentali di tumore e (iii) l'analisi di dati di diffusione in pazienti affetti da ischemia cerebrale. Particolare enfasi sarà posta sugli aspetti tecnici che riguardano gli algoritmi ed i metodi di elaborazione utilizzati nel processo di analisi.<br>Magnetic resonance imaging (MRI) is increasingly being used in medical settings because of its ability to produce, non-invasively, high quality images of the inside of the human body. Since its introduction in early 70’s, more and more complex acquisition techniques have been proposed, raising MRI to be exploited in a wide spectrum of applications. Innovative MRI modalities, such as diffusion and functional imaging, require complex analysis techniques and advanced algorithms in order to extract useful information from the acquired data.
The aim of the present work has been to develop and optimize state-of-the-art techniques to be applied in the analysis of MRI data both in experimental and clinical settings. During my doctoral program I have been actively involved in several research projects, each time facing many different issues. In this dissertation, however, I will report the results obtained in three most appealing projects I partecipated to. These projects were devoted (i) to the implementation of an innovative experimental protocol for functional MRI in laboratory animals, (ii) to the development of new methods for the analysis of Dynamic Contrast Enhanced MRI data in experimental tumour models and (iii) to the analysis of diffusion MRI data in stroke patients. Particular emphasis will be given to the technical aspects regarding the algorithms and processing methods used in the analysis of data.
7
Catrina, Sergiu-Bogdan. "Regulators of angiogenesis in diabetes and tumors /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-628-6682-6/.
Full text
8
Hebrant, Aline. "Pathologies thyroïdiennes et modèles in vitro: profils d'expression génique et phénotypes moléculaires." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210139.
Full textAbstract:
La thèse s’inscrit dans un projet de recherche global visant à caractériser les tumeurs thyroïdiennes sur le plan moléculaire, afin de mieux comprendre leur physiopathologie et afin d’identifier des biomarqueurs (signatures moléculaires) qui pourront être utilisés pour le diagnostic, le pronostic et leur traitement. Parmi celles-ci, nous distinguons les adénomes autonomes (AA) et folliculaires (FTA) tumeurs bénignes encapsulées, et les carcinomes, tumeurs malignes. Ceux-ci sont eux-mêmes subdivisés en carcinomes différenciés, folliculaires (FTC) ou papillaires (PTC), et peuvent évoluer en carcinomes anaplasiques (ATC), totalement dédifférenciés. Un autre type de tumeurs bénignes différenciées, très rares, existe: l’hyperthyroïdie non auto-immune familiale (FNAH). Ces tumeurs sont causées pour la plupart par des mutations qui activent de manière constitutive des cascades de signalisation, essentiellement la cascade de l’AMPc et la cascade des MAPK. Le but de notre thèse était de valider un système expérimental in vitro des PTC, d’étudier les profils d’expression génique des FNAH et de les comparer avec ceux des AA, et de définir les profils ARNm et miRNA des ATC pour les comparer à ceux des PTC pour identifier de nouvelles cibles thérapeutiques potentielles. Pour réaliser ces objectifs, nous avons utilisé la technologie des microarrays qui permet d’analyser simultanément l’expression de milliers de gènes dans différentes conditions. Nous avons donc utilisé une approche multidisciplinaire alliant une partie expérimentale et une partie bioinformatique.<p><p>La première partie du travail a consisté à réaliser un modèle d’étude in vitro pour caractériser les PTC au niveau moléculaire. A cet effet, des cultures primaires de thyrocytes ont été traitées avec de l’EGF et du sérum pendant différents temps (1,5h, 3h, 16h, 24h et 48h) ce qui stimule la cascade des MAPK, activée constitutivement dans les PTC. Nous avons hybridé sur des lames microarrays maison les différents échantillons et nous avons montré que les cultures primaires stimulées pendant des temps longs (24h et 48h) ont des profils d’expression génique qui ressemblent à ceux des PTC et constituent donc un bon modèle d’étude de cette tumeur. <p><p>La seconde partie a pour objectif de définir les phénotypes moléculaires et fonctionnels des FNAH et de les comparer aux AA. Ces deux pathologies résultent d’une mutation dans le récepteur de la TSH (TSHR) activant de manière constitutive la cascade de l’AMPc. Dans le cas des FNAH, la mutation est héréditaire et toute la glande est affectée contrairement aux AA où la mutation survient plus tard, généralement à l’âge adulte, et où seule une partie de la glande est affectée. Nous avons comparé le profil d’expression génique des FNAH avec celui des AA, par hybridation sur des lames microarrays HEEBO. L’intégration de ces différentes données montre que les AA et les FNAH sont deux sous-types différents de la même maladie: l’hyperthyroïdie génétique. Les caractéristiques de chacun de ces sous-types dépendent de l’intensité de la mutation, du nombre de cellules initialement affectées et du stade de développement au moment duquel la mutation survient.<p><p>Dans la dernière partie de ce travail, nous avons caractérisé les ATC au niveau du profil d’expression des ARNm et des miRNA par hybridation respectivement sur lames Affymetrix ou sur lames miRNA maison et au niveau de leur état mutationnel du gène p53. Le profil d’expression génique des ATC a été comparé avec celui des PTC afin de mettre en évidence des gènes différentiellement exprimés entre les 2 types de cancers, que nous avons ensuite tenté d’invalider par siRNA, dans un modèle in vitro de lignée cellulaire thyroïdienne dérivée d’un ATC (8505C). Les résultats obtenus jusqu’ici ne sont malheureusement pas prometteurs. Le profil d’expression des miRNA nous a permis d’identifier une signature de 34 miRNA caractéristique des ATC.<p><br>Doctorat en Sciences biomédicales et pharmaceutiques<br>info:eu-repo/semantics/nonPublished
9
Elliott, Bradley Thomas. "Lipopolysaccharide-induced Inflammation Regulates Myostatin Expression in L6 cells via a Tumour Necrosis Factor-dependent Mechanism." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26280/26280.pdf.
Full text
10
Wagner, Manuela. "Maligne Tumoren als Zufallsbefunde bei klinischen Obduktionen - Eine retrospektive Untersuchung am Obduktionsgut des Institutes für Pathologie des Universitätsklinikums Leipzig." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-124575.
Full textAbstract:
Auf der Basis der Obduktionsprotokolle der Jahre 2000-2009 des Institutes für Pathologie des Universitätsklinikums Leipzig wurden die Häufigkeiten und Verteilungen maligner Tumoren sowie der zu Lebzeiten nicht bekannten malignen Tumoren untersucht.
Bei insgesamt 4592 durchgeführten Sektionen wurden in 263 Fällen zu Lebzeiten nicht bekannte maligne Tumoren diagnostiziert. Dies entsprach 5,7% des gesamten Sektionsgutes bzw. 20,2% aller nachgewiesenen Malignome.
Nach Analyse der pTNM-Klassifikation wurden 70,9% der Malignome in den Tumorkategorien pT1 und pT2 erfasst. In 24,7% der Fälle traten Lymphknotenmetastasen, in 19,4% Fernmetastasen auf.
23,2% der postmortal entdeckten Malignome waren todesursächlich. Über die Hälfte der Obduzierten mit klinisch nicht bekannten Tumoren waren 70 Jahre oder älter.
Die häufigsten klinisch nicht bekannten malignen Tumoren waren die Prostatakarzinome (23,9%), die kolorektalen Karzinome (16,3%), die Nierentumoren (13,0%), die Lungenkarzinome (12,7%) sowie die Leberkarzinome (6,5%).
Patienten mit synchronen Doppel- beziehungsweise Dreifachtumoren traten bei 1,8% des Sektionsgutes auf. Der Anteil nicht erkannter maligner Tumoren an den Mehrfachmalignomen betrug 41,7%.
Diese Sektionsanalyse bestätigte, dass auch im 21. Jahrhundert trotz der rasanten Entwicklungen in Medizin und Technik weiterhin maligne Tumoren erst bei der Autopsie festgestellt werden.
Books on the topic "Tumor pathologies"
1
Pierro, Picci, and Gold Richard H, eds. Bone tumors: Clinical, radiologic, and pathologic correlations. Lea & Febiger, 1989.
Find full text
2
1957-, Swanson Paul E., ed. Cutaneous adnexal tumors: A guide to pathologic diagnosis. ASCP Press, 1991.
Find full text
3
E, Voest Emile, and D'Amore Patricia A, eds. Tumor angiogenesis and microcirculation. Dekker, 2001.
Find full text
4
D, Marmé, and Fusenig N. E, eds. Tumor angiogenesis: Basic mechanisms and cancer therapy. Springer, 2007.
Find full text
5
Adler, C. P. Primary bone tumors and tumorous conditions in children: Pathologic and radiologic diagnosis. Springer-Verlag, 1993.
Find full text
6
Kramer, Ivor R. H. Histological typing ofodontogenic tumours. 2nd ed. Springer-Verlag, 1992.
Find full text
7
MD, Wu Maoxin, Penault-Llorca Frédérique, Deligdisch Liane, and Altchek Albert 1925-, eds. Early pathologic diagnosis of gynecologic cancer including a clinician's view. World Scientific, 2009.
Find full text
8
J, Cote Richard, ed. Immunomicroscopy: A diagnostic tool for the surgical pathologist. 2nd ed. Saunders, 1994.
Find full text
9
J, Cote Richard, ed. Immunomicroscopy: A diagnostic tool for the surgical pathologist. 3rd ed. Saunders, 2006.
Find full text
10
American College of Veterinary Pathologists. Annual Meeting. Neoplasia: Forty-seventh Annual Meeting of the American College of Veterinary Pathologists : December 2-December 6, 1996, Sheraton Seattle Hotel & Towers, Seattle, Washington. s.n., 1997.
Find full textBook chapters on the topic "Tumor pathologies"
1
Morelli, Maria Beatrice, Sonia Liberati, Consuelo Amantini, et al. "Epigenetic, Genetic, and Acquired Regulation of Cav3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression." In Pathologies of Calcium Channels. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40282-1_15.
Full text
2
Naeger, David M. "Diseases of the Pleura and Chest Wall." In IDKD Springer Series. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-83872-9_4.
Full textAbstract:
Abstract The pleura is comprised of a visceral and parietal layer. The potential space between the two is normally filled with a small amount of physiologic fluid. The visceral pleura invaginates to form fissures, and collectively the pleura allows the lobes of the lungs to move relative to each other and the chest wall during respiration. In diseased states, this potential space can fill with abnormal amounts, or atypical types, of fluid. The pleura can become thickened, often in response to infection, inflammation, or exposures. Tumors can also arise from the pleura. Malignant pleural mesothelioma is a particularly aggressive primary tumor of the pleura, which is associated with asbestos exposure. Owing to lymphatics and vascularity, the pleura can also be the site of tumors deposits from malignancies originating outside the pleura. Ectopic tissues may also be found within the pleural space. The chest wall is external to the pleura, and it is comprised of skin, various fat layers, fascia, muscles, nerves, lymphatics, and bone. Primary tumors, both benign and malignant, and metastases can involve the various layers of the chest wall. There are a few specific pathologies that are unique to the chest wall, which will be reviewed. As a final category, there are a few disease entities, mostly infection and cancer, which can affect both the pleura and the chest wall simultaneously.
3
Rekhtman, Natasha, Marina K. Baine, and Justin A. Bishop. "Tumor Genetics and Cytogenetics: Solid Tumors." In Quick Reference Handbook for Surgical Pathologists. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-97508-5_10.
Full text
4
Agni, Nisheet Anant. "Salivary Gland Pathologies." In Oral and Maxillofacial Surgery for the Clinician. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_46.
Full textAbstract:
AbstractSaliva is responsible for various functions from lubrication to digestion. The saliva is secreted by numerous minor and major salivary glands. These salivary glands are sometimes affected by various local and systemic inflammatory conditions, obstructive pathologies with benign and malignant tumors. This chapter deals with various pathologies of salivary glands and their management.
5
Goldin, Jonathan. "Mastering Mediastinal Imaging: Tips, Tricks, and Key Diagnoses." In IDKD Springer Series. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-83872-9_2.
Full textAbstract:
Abstract Imaging plays a pivotal role in diagnosing, managing, and monitoring mediastinal and hilar diseases, which encompass a diverse range of benign, malignant, infectious, and inflammatory conditions. These diseases are localized within the complex mediastinum, which is anatomically divided into prevascular, visceral, and paravertebral compartments. Each compartment is associated with specific pathologies, enabling imaging-based localization to narrow differential diagnoses and guide clinical management. This review explores the imaging features, clinical presentations, and implications for the eight most common mediastinal and hilar diseases: mediastinal and hilar lymphadenopathy, thymoma, bronchogenic cyst, neurogenic tumor, substernal thyroid goiter, lymphoma, teratoma, and sarcoidosis. Computed tomography (CT) and magnetic resonance imaging (MRI) are the primary modalities for characterizing these conditions, while positron emission tomography (PET) aids in assessing metabolic activity, particularly in malignancies and active inflammation. Key imaging features such as location, attenuation, calcifications, enhancement patterns, and metabolic activity inform differential diagnoses and management decisions. Clinical implications include determining disease extent, staging malignancies, planning surgical interventions, and guiding biopsies. Understanding the characteristic imaging patterns and their clinical correlations is essential for radiologists and referring physicians to optimize patient care in these complex and often overlapping conditions. This review provides practical insights and imaging pearls to improve diagnostic accuracy and treatment planning for these diseases.
6
Rekhtman, Natasha, Marina K. Baine, and Justin A. Bishop. "Tumor Syndromes." In Quick Reference Handbook for Surgical Pathologists. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-97508-5_12.
Full text
7
Rekhtman, Natasha, Justin A. Bishop, and Ashlie L. Burkart. "Tumor Syndromes." In Quick Reference Handbook for Surgical Pathologists. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20086-1_7.
Full text
8
Johnson, Lent, and Michael Mulligan. "Pathologic/Radiologic Correlation." In History of Bone Tumor Pathology and Radiology. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-64703-1_6.
Full text
9
Icli, Mehmet Cihan, and Baran Akagunduz. "Immunotherapy in Breast Cancer." In Immunotherapy in Human Cancers. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359388.13.
Full textAbstract:
Breast cancer is the most common cancer in women and a multidisciplinary approach has reduced breast cancer mortality. Early stage and locally advanced breast cancers require systemic therapy to reduce recurrence and relapse. Pathologic complete response (pCR) has been one of the main targets of neoadjuvant systemic therapy. With the advent of immune checkpoint inhibitors (ICIs), Immunotherapy has revolutionized the treatment of solid tumors. Immunotherapy in breast cancer has been used especially in the immunogenic subtype of TNBC (triple-negative breast cancer), which has higher levels of TIL (tumor-infiltrating lymphocytes). The KEYNOTE-522 study showed that adding pembrolizumab to neoadjuvant chemotherapy increased pCR rates in patients with early-stage TNBC. The IMPASSION031 study also showed that the combination of atezolizumab and nab-paclitaxel increased the pCR rate from 41% to 58%. In the KEYNOTE-355 study, the addition of pembrolizumab to chemotherapy in patients with TNBC with a combined positive score (CPS) ≥10 significantly improved progression-free and overall survival. Current studies are investigating various combinations of chemotherapy and immunotherapy, as well as new immunotherapeutic agents in combination with tumor vaccines, oncolytic viruses and adaptive cellular therapy.
10
Rekhtman, Natasha, Justin A. Bishop, Ashlie L. Burkart, and Amy S. Duffield. "Tumor Genetics and Cytogenetics." In Quick Reference Handbook for Surgical Pathologists. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20086-1_8.
Full textConference papers on the topic "Tumor pathologies"
1
Hampel, U., E. Schleicher, H. Zepnick, and R. Freyer. "Clinical NIR spectroscopy and optical tomography of the testis." In European Conference on Biomedical Optics. Optica Publishing Group, 2001. http://dx.doi.org/10.1364/ecbo.2001.4432_210.
Full textAbstract:
Optical tomography and NIR spectroscopy are potential methods to improve the diagnosis of testicular pathologies. To evaluate the methods clinically we developed a special measurement device with the capability of spatially resolved laser spectroscopy and optical tomography of the testis. Simple spectroscopy is primarily used to obtain global tissue optical properties of the testis and to find correlations of optical parameters with type and stage of certain pathologies. Optical tomography is applied to visualize spectral contrasts in limited tissue volumes, such as tumors. In the course of the study we will determine whether NIR techniques posses the required specifity and sensitivity to give additional quantitative information about tissue perfusion parameters and to serve for a tumor differentiation.
2
Saidalieva, Mahruy, Margarita Gildieva, Anvar Abduvaliev, and Mohiniso Hidirova. "Mathematical modeling of regulatory mechanisms of cardiological pathologies in the tumor process." In 2019 International Conference on Information Science and Communications Technologies (ICISCT). IEEE, 2019. http://dx.doi.org/10.1109/icisct47635.2019.9011868.
Full text
3
Gubernatorova, Viktoriia Aleksandrovna, Tatiana Schamilievna Kuznetsova, and Boris Stepanovich Semenov. "SURGICAL TREATMENT OF TUBULAR CARCINOMA OF THE MAMMARY GLAND IN A LANDSEER DOG." In Themed collection of papers from Foreign International Scientific Conference «Modern research on the way to a new scientific revolution». Part 2. by HNRI «National development» in cooperation with AFP (Puerto Cabezas, Nicaragua). November 2023. – Varadero (Cuba). Crossref, 2024. http://dx.doi.org/10.37539/231128.2023.80.27.017.
Full textAbstract:
A mammary tumor in dogs is one of the most common pathologies that occurs due to a combination of different factors. There are several methods of therapy, each of which has its own positive and negative sides. The most commonly used surgical intervention is mastectomy, as one of the effective treatment options.
4
Santo, Mateus Lodi do Espírito, and Renata Dellalibera-Joviliano. "The impacts of pesticide use in food production as a potential bioaccumulator in breast milk." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-114.
Full textAbstract:
The ingestion of food contaminated by pesticides enables several pathologies in humans, such as mainly the bioaccumulation of agrochemicals in breast milk, which highlights a scenario of extreme concern, since these products have a high potential to induce genetic disorders not only in the mother, but also to the baby through breastfeeding. The purpose of this literature review is to highlight the toxicological action that the use of pesticides in agricultural crops provides to newborns through breastfeeding. The methodology used was based on 15 scientific articles, which were found through a search with a filter for the English language and the Boolean operator "AND", being carried out on the Scientific Library Online (SciELO) and PubMed digital platforms, using the descriptors indexed in DeCS / MeSH: Milk human; Agrochemicals; Bioaccumulation; Poisoning. The references were filtered by selecting those published between 2015 and 2023. In view of the results obtained, pesticides that use organochlorines in their composition, such as glyphosate, for example, stand out, which confer easy absorption through the skin. After absorption, the substances can diffuse between membranes and accumulate in organs with high levels of fat, such as breast tissue, mainly. Thus, milk from lactating women promotes the exposure of newborns to these toxicological substances, which can stimulate the development of cancer, leukemia, lymphoma, and brain tumor, followed by the impairment of the immune system. This situation becomes even more alarming because breast milk is the only food that provides the essential nutrients for infant growth, causing not only the pathologies mentioned above but also a series of chronic psychomotor disorders. In conclusion, it can be inferred that the use of pesticides in crops causes a series of permanent and neoplastic disorders to newborns, thus impairing healthy child development.
5
Souza, Priscila M., Filomena M. Carvalho, Fernando N. Aguiar, Débora Gagliato, and Alfredo C. S. D. Barros. "ASSOCIATION BETWEEN GATA3 AND PATHOLOGIAL AND IMMUNOHISTOCHEMICAL PREDICTIVE AND PROGNOSTIC PARAMETERS IN EARLY BREAST CANCER." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1046.
Full textAbstract:
Introduction: GATA3 gene, at 10p14, a member of the GATA family with two GATA-type zinc-fingers, encodes the transcription factors GATA - binding protein 3 (GATA3), critical for the luminal breast epithelium development and maintenance. The GATA3 protein is a linear one, with more than 400 aminoacids, that can be recognized by immunohistochemical analysis. Mutations of the GATA3 and loss of the expression of its related protein are implicated in breast cancer development and aggressiveness. As the most frequent transcription factor in luminal tumor cells, GATA3 became an important marker of mammary differentiation in neoplasias of unknown origin, better than mammaglobin and gross cystic disease fluid protein (GCDFP). Objectives: In this study, we aimed at assessing pathological and immunohistochemical variables and their association with GATA3 expression, adding bases for breast carcinogenesis comprehension and BC (Breast Cancer) precision therapy. Methods: GATA3 was analyzed by immunohistochemistry in whole histological sections of tumors from 105 female patients with histological diagnosis of invasive breast carcinoma and at clinical stages I, II and IIIA, who underwent primary surgical treatment (protocol approval number: 1,604,792). GATA3 nuclear expression was determined in percentage of tumor cells and categorized as preserved (positive expression in more than 95% of cells) or reduced (negative or expression in up to 95% of tumor cells). GATA3 expression was analyzed according to patient’s age, tumor and node pathological stage, histological type, histological and nuclear grade, lymphovascular invasion, estrogen receptor, progesterone receptor, androgen receptor, HER2 status, and Ki-67. Results: GATA3 expression was detected in 103/105 (98.1%) cases. Reduced expression was associated with higher histological and nuclear grade, negative hormonal receptors, HER2-positive and higher proliferative activity according to Ki-67 expression. Triple negative breast carcinomas (TNBC) and ER-negative/HER2-positive presented the highest frequency of GATA3 reduction (75%) compared to ER-positive/HER2-negative (4.1%) and ER-positive/HER2-positive (20%). Proliferative activity in TNBC tended to be higher among tumors with GATA3 reduced, irrespective of androgen receptor expression. In the group of ER-positive/ HER2-negative tumors only 3 cases presented GATA3 reduction, all of them with high proliferative activity. Conclusions: GATA3 expression is present in almost all cases of early breast cancer. Reduction in its expression is associated with adverse prognostic factors and higher proliferative activity in all subtypes, including ER-positive/HER2-negative tumors.
6
Silva, Maria Gabriela Ferreira, Isabella Cristina Santos Soares, Flávia Pinto Cardozo, Flávia Maria Souza Clímaco, and Aguinaldo Ferreira Leite Filho. "COMPLETE PATHOLOGICAL RESPONSE AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS: ANALYSIS OF 83 PATIENTS TREATED AT A FEDERAL PUBLIC SERVICE." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1057.
Full textAbstract:
Introduction: Neoadjuvant chemotherapy is performed before surgical treatment and aims to make a locally advanced tumor operable, provide conservative treatment, demonstrate tumor sensitivity in vivo and evaluate the pathological response (PR) to treatment. PR is an important prognostic factor, and several studies have demonstrated a correlation between the biological factors of the tumor and its response rate. Patients with a pathologic complete response (PCR) present a longer survival rate compared to those with residual disease. Objectives: The main objective was to assess PCR in patients with breast cancer undergoing neoadjuvant chemotherapy. As secondary objectives, we identified clinical-pathological variables related to PCR and correlated the pathologic response in the breast with the axillary response after chemotherapy. Methods: Four hundred and forty-four medical records of patients seen in the Mastology sector were reviewed between January 2016 and July 2019. Eighty-three patients were selected, with 361 cases that did not meet the inclusion criteria being excluded. The exclusion criteria were benign disease, neoadjuvant hormone therapy, neoadjuvant radiation therapy, trastuzumab associated with chemotherapy, upfront surgery and patients who did not receive surgical treatment after chemotherapy. The variables analyzed were age, tumor size, axillary involvement, histological type and grade, molecular subtype and PCR. Results: Most patients were over 50 years of age (62%) and had tumors larger than 5 cm (75%). Fifty of them (60%) had initial axillary involvement. Among the 83 patients, 64 (77%) did not obtain a pathologic response in the breast and armpit. Two (3%) showed a response only in the breast. PCR was observed in 17 patients (20%) and almost half of them were under 50 years of age (47%). Moderately differentiated (grade 2) and undifferentiated (grade 3) tumors, accounted for 96% of cases and had a higher rate ofPCR than grade 1 tumors. In HER2 positive subtypes, PCR occurred in 36% and in negative triples in 22%, being higher than in luminous A and B subtypes (15% and 17%, respectively). Conclusions: The histological grade and molecular subtypes correlate with the pathologic response to neoadjuvant chemotherapy. More undifferentiated tumors and the triple negative and HER 2 positive molecular subtypes have a higher PCR rate. Despite the small sample, the results of this study were similar to those in the medical literature. A higher number of cases is necessary to corroborate the data obtained, as well as a longer follow-up time to demonstrate the relationship between PCR and survival.
7
Amooshahi, M., and A. Samani. "A Fast Constrained Nonlinear Elastography Technique: Polyvinyl Alcohol (PVA) Phantom Study Using the Veronda-Westman Model." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-37740.
Full textAbstract:
Breast elastography has been proposed as a novel imaging modality for breast cancer detection and assessment. As pathologies are known to change tissue stiffness significantly, the idea behind elastography is using tissue stiffness as imaging contrast agent. Evidence in the literature suggests that various pathological tissues exhibit different mechanical stiffness characteristics. Therefore, in addition to the ability of detecting the presence of abnormalities, elastography is capable of pathological tissue classification. In this work, we propose a novel nonlinear (hyperelastic) breast elastography system which takes into account tissue large deformations resulting from mechanical stimulation. To idealize breast tissue, we use the well-known Veronda-Westman model as the forward problem solution in the hyperelastic parameter reconstruction process. This process involves tissue mechanical stimulation, displacement data acquisition followed by solving an inverse problem to find the hyperelastic parameters iteratively. These parameters are useful for in vivo tumor classification, image guided surgery and Virtual Reality systems development. Due to the exponential form of the Veronda-Westman function, however, this model cannot be solved using inverse-matrix techniques. Therefore, we have developed a novel technique to solve the corresponding nonlinear inverse problem. To validate the technique, we used an experimental breast tissue mimicking phantom that was made up of PVA-C (Polyvinyl Alcohol), which exhibits nonlinear mechanical behavior. Displacement data was acquired using a combination of Time Domain Cross-Correlation Estimation (TDE) and Horn-Schunck Optical Flow techniques.
8
Soares, Gilandira Ivanda Da Costa, and Josmara Ximenes Andrade Furtado. "CORRELATION OF CLINICAL-PATHOLOGICAL VARIABLES WITH THE PATHOLOGIC COMPLETE RESPONSE AFTER NEOADJUVANT CHEMOTHERAPY IN TRIPLE-NEGATIVE BREAST CANCER." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1059.
Full textAbstract:
Introduction: The triple-negative breast cancer (TNBC) is one of the most aggressive types of breast cancer, corresponding to about 15% to 20% of invasive breast tumors. They are those tumors that in immunohistochemistry do not express homone receptors and epidermal growth factor type 2 (cerbB2). This tumor phenotype does not yield many treatment options, beyond standard chemotherapy, and within this context, the evidence of some markers of this type of tumor may contribute to the discovery of more effective types of treatment. Case report and Objectives: The aim of this study was to define predictive and prognostic factors in TNBC that could be related with a pathologic complete response after neoadjuvant chemotherapy treatment. Methods: A descriptive and retrospective study, a case series type, in women with TNBC who had underwent neoadjuvant chemotherapy and surgery at the Mastology Service of Maternidade Escola Assis Chateaubriand – Brazil - from May 2015 to June 2020. A statistical analysis was performed considering the 5% significance level. Results: From 108 women, only 47 were included in the study, with median age of 49 years (+14 years); about 30 (42.6%) had a family history of breast cancer in first or seconddegree relatives. About 44 (93.6%) cases were classified as invasive ductal tumor and grade II or III; the value of Ki67 greater than 14% was evidenced in 46 (97.9%) women and 26 (55.3%) had clinical stage III. Pathologic complete response to chemotherapy was evidenced in 16 (34%) cases, partial response in 13 (27.7%) and no response in 18 (38.3%) cases. The latter cases correspondeded to those who had stable or progression of disease. There was recurrence in 13 (27.7%) women, about 8 distant metastases, with the lungs as the most frequent site of metastasis followed by the brain. Eleven patients, about 23.4%, died. In the survival analysis of the studied population, the overall survival was 5.6 months and disease-free survival was 19.4 months. No association was observed in the study between the outcome of pathologic complete response to neoadjuvant chemotherapy and anatomopathological characteristics of the tumor. Conclusion: The results of this study did not show statistical significance to determine the possible predictive and prognostic factors for obtaining a complete clinical response to TNBC in a public reference service for the treatment of breast cancer, where there is no genetic signature, PDL1 status or access to differentiated treatment for such a heterogeneous tumor profil. This shows a need for further studies in order to understand this disease and for greater accessibility to high-cost exams and more effective treatments.
9
Suchkov, Sergey. "Personalized Bringing the Promise of Personalized and Precision Medicine (PPM) to Rare and Orphan Disorder Care: The Future of PPM through the View of Biodesign-inspired Hi-Tech Philosophy, Upgraded Mentality and Global Needs of the Consumers." In World Conference on Gynecology, Obstetrics, and Pediatrics. Eurasia Conferences, 2025. https://doi.org/10.62422/978-81-981865-0-8-014.
Full textAbstract:
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). The concept of PPM is becoming increasingly relevant for cancer treatment, moving from the ‘one-size-fits-all’ standard therapy to a more personalized scheme guided by molecular diagnostics. A comprehensive molecular tumor analysis integrating a combination of NGS methods including whole-exome (WES), whole-genome (WGS) and transcriptome sequencing (RNAseq) offers the best chance for personalizing cancer care, enlarging the scope of therapy choices and offering potential new options for challenging cases, for instance metastatic tumors, rare cancer types, and cancers of unknown primary. Cutting-edge bioinformatics pipelines integrate the multiple data levels to con-struct Big Data and Data Sets and to generate a personalized tumor report. One key asset of this so-lution is the use of whole transcriptome data as a booster enhancing the sensitivity and information content of the diagnostic, predictive and prognostic tests. Up to now personalized and precision on-cology has been largely relying on identifying key mutations in the tumor DNA by means of panel sequencing, a method scanning only designated cancer gene targets. Though the panel approach helps to orientate therapy choices for particular cancer types, many “hard to treat” tumors remain in need of more effective diagnostic solutions. The improvement of methodology for OMICS-based (i.e., genomic) testing has made it one of the cornerstones of PPM-driven cancer clinical practice, which would incorporate various genomic, pro-teomic and other assays of human cancers into diagnostic, predictive, prognostic, and decision-making algorithms. A consolidated team of molecular pathologists, IT experts and cancer practition-ers of the next step generation are becoming to play a crucial role in developing and implementing OMICS-based profiling tests in practice and communicate the results and their relevance with clini-cians. Such approach is considered to be of utmost importance for successfully translating the latest advancements into a benefit to patients, illustrating a generation of the “next-generation cancer pathologists, cancer-related practitioners and oncologists globally”. Another essential aspect in which the cancer-related pathologists and practitioners play a crucial role is developing and implementing OMICS-based tests being integrated with the frame of IT algo-rithms, in clinical oncology and communicating the obtained results with other diagnostic and thera-peutic disciplines (e.g., microbiology, clinical enzymology, genetics, immunology, etc) and clini-cians.
10
Freitas, Laura Rabelo de, Lilian Cristina Silva da Costa, Maria Gabriela Ferreira da Silva, Luiza Rodrigues Batista, and Rafael Henrique Szywanski Machado. "EPIDEMIOLOGICAL CHARACTERISTICS AND INCIDENCE OF BREAST CANCER IN MALE PATIENTS IN A TERTIARY HEALTH INSTITUTION." In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1030.
Full textAbstract:
Introduction: Despite the rare incidence of malignant breast pathologies in men, it is extremely important to pay attention to any complaints related to breast alterations in men. Benign and malignant breast diseases are uncommon in men. In addition, most of the male population can be careless when it comes to their own health, especially in breast diseases, commonly seen as an exclusive condition for women. Objective: The aim of this study was to analyze the epidemiological profile of male patients treated at the Mastology Clinic in Rio de Janeiro, Lagoa’s Federal Hospital (HFL), a tertiary health institution. Methods: In total, 40 medical records of patients who were assisted during 2020 and 2021 were evaluated. Results: The majority of patients were between 30 and 70 years old, and the major complaints (97%) were related to a tumor or to breast volume increase. Sixty percent of the patients were diagnosed with gynecomastia and, as a consequence, have been regularly observed throughout appointments since then. Some of these patients (12.5%) have reported the use of anabolic substances before the discovery. The breast cancer incidence in this male population was 22.5% during this period, and the patients affected by malignant tumors were between 47 and 74 years old. Most patients with breast cancer smoked (55%) and drank alcohol (22%). No patient had breast cancer in family history and only one patient was related to a family history of prostate cancer. A total of 66.6% of the male breast cancer in this study population was positive for hormone receptors, and the papillary carcinoma of the breast was the predominant histological type (44.4%). Conclusion: As other studies indicate, all of the patients were in an advanced stage of the disease since the first appointment at HFL. Low educational level, no knowledge about possible male breast cancer, insecurity, shyness and fear of possible social judgments about breast increase (especially in older patients), and carelessness when it comes to their own health were the preponderant factors for a clinically advanced disease among the patients at HFL. These factors were also relevant for a bad adaptation to the treatment, as well as emotional shakiness during therapy and follow-up: some patients showed symptoms such as apathy, deep sadness, and even depression. The male population assisted by the Mastology Clinic at HFL has similar features as the ones in equivalent studies. This research confirms the necessity of an increase in male’s Health Care Education, family participation during treatment, and interdisciplinary care, considering the physical and emotional consequences of such diagnosis.
Reports on the topic "Tumor pathologies"
1
KHAIRALLAH, Sara, and EL HARROUDI Tijani. Delayed coloanal anastomosis technique in the management of low-lying rectal cancer: systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0002.
Full textAbstract:
Review question / Objective: Is there a difference in terms of post-operative events between delayed and immediate coloanal anastomoses in the management of rectum carcinoma? Condition being studied: Rectal carcinoma. Eligibility criteria: We defined the lower rectum as any rectal tumor located within 6cm of the anal margin or within 2cm of the upper edge of the sphincter ring.- All scientific articles published or not published between 01/1985 and 09/2021 that aim to demonstrate the postoperative, oncological and functional results of ACAD in the curative treatment of adenocarcinoma of the lower rectum or rectal cancer including the lower rectum.- Scientific articles that discuss case series treated with ACAD in different benign or malignant pathologies, but where patient data and results of this procedure are well individualized in patients operated on rectal adenocarcinoma. - Abstracts of conference sessions, theses or unpublished articles (grey literature) with complete data, allowing their extraction and processing in our review.Translated with http://www.DeepL.com/Translator (free version).
2
Ragunathan, Yoithapprabhunath Thuckanaickenpalayam, Srichinthu Kenniyan Kumar, Deepak Gupta, Diksha Singh, Swetha Pasupuleti, and Madhavan Nirmal Ramdas. Effectiveness of Neoadjuvant Molecular-Targeted Chemotherapy in Ameloblastoma - A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0018.
Full textAbstract:
Review question / Objective: The aim of this article is to obtain an in-depth review of ameloblastoma tumor to determine the available level of evidence and the possible benefit of targeted therapeutics for the treatment of BRAF V600E mutation in ameloblastoma tumor. Condition being studied: Ameloblastoma is an epithelium-derived odontogenic tumour that evolved since the prehistoric era. Ameloblastoma is unique among the odontogenic neoplasms occurring in the jaws, because of its locally invasive behaviour and high recurrence rate. Facial asymmetry, displacement of teeth, malocclusion, and pathologic fractures are some of the asymmetrical features that ameloblastoma is known to cause. If left untreated, they often lead to wide tissue destruction and deformity. For the treatment of ameloblastomas, conventional chemotherapy and radiation have been unexplored or contraindicated and to date, wide surgical resection is the only treatment of choice for ameloblastoma tumours, resulting in post-treatment compromised quality of life in the individuals.
3
Symmans, W. F. Integration of Pathologic Findings With Clinical-Radiologic Tumor Measurements to Quantify Response to Neoadjuvant Chemotherapy. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada455291.
Full text
4
Symmans, William F. Integration of Pathologic Findings With Clinical-Radiologic Tumor Measurements to Quantify Response to Neoadjuvant Chemotherapy. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada433045.
Full text
5
Symmans, William F. Integration of Pathologic Findings With Clinical-Radiologic Tumor Measurements to Quantify Response to Neoadjuvant Chemotherapy. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada420419.
Full text