Books on the topic 'Tumor Size Growth Rate'

Growth involves two flows of energy. The first is chemical potential energy in the monomers used to construct the proteins, lipids, polysaccharides and nucleic acids forming the new tissue. The second is the metabolic energy (ATP or GTP) used to construct the new tissue; this is the metabolic cost of growth and can be expressed as a dimensionless fraction of the energy retained in the new tissue. Its value is ~0.33. Typical temperature sensitivities for growth in the wild lie in the range Q10 1.5 – 3. Within species there may be evolutionary adjustments to growth rate to offset the effects of temperature, though these involve trade-offs with other physiological factors affecting fitness. Outside the tropics, many mammals and birds exhibit a cline in size, with larger species at higher latitudes (Bergmann’s rule). Carl Bergmann predicted such a cline from biophysical arguments based on endotherm thermoregulatory costs; Bergmann’s rule thus applies only to mammals and birds. Many ectotherms grow more slowly but attain a larger adult size when grown at lower temperatures (the temperature-size rule). The large size of some aquatic invertebrates at lower temperatures (notably in the polar regions and the deep sea) is associated with a higher oxygen content of the water.

This book examines the links between economic growth, changing employment conditions, and the reduction of poverty in Latin America in the 2000s. Its analysis answers the following broad questions: Has economic growth resulted in gains in standards of living and reductions in poverty via improved labour market conditions in Latin America in the 2000s, and have these improvements halted or been reversed since the international crisis of 2008? How do the rate and character of economic growth, changes in the various employment and earnings indicators, and changes in poverty and inequality indicators relate to each other? Our contribution is an in-depth study of the multi-pronged growth–employment–poverty nexus based on a large number of labour market indicators (twelve employment and earnings indicators and four poverty and inequality indicators) for a large number of Latin American countries (sixteen of them). The book presents a positive and hopeful set of findings for the period 2000 to 2012–13. Economic growth took place and brought about improvements in almost all labour market indicators and consequent reductions in poverty rates. But not all improvements were equal in size or caused by the same things. Some macroeconomic factors were associated with changes in labour market conditions, some of them always in the welfare-improving direction and others always in the welfare-reducing direction. Most countries in the region suffered a deterioration in at least some labour market indicators as a consequence of the international crisis of 2008, but the negative effects were reversed very quickly in most countries.

Physical activity in the general youth population and systematic training for sport among young athletes seems to have no effect on size attained and rate of growth in height, or on maturity status and timing. However, activity and training may influence body weight and composition. While both favourably influence bone mineral, variable effects are noted in some sports. Activity has a minimal effect on fatness in normal weight youth, but regular training generally has a positive influence on fatness in youth athletes. Data for fat-free/lean tissue mass are suggestive, but limited. Constitutional factors play a central role in the selection and retention of young athletes in a sport.

Intracranial aneurysms may be detected incidentally on imaging. Location and size of an intracranial aneurysm are helpful in stratifying risk of hemorrhage. Risk stratification is important for treatment decision-making. Modifiable risk factors associated with aneurysm growth and rupture (hypertension and tobacco use) should be addressed. Treatment needs to be individualized. Small aneurysms may be monitored. Surgery has been associated with neurological disability and cognitive impairment. Endovascular coiling may be associated with a higher rate of incomplete obliteration. There are no randomized trial data in patients with unruptured aneurysms.

Despite a relatively limited understanding of the factors associated with strength development, advances in equipment, and increased understanding of growth and maturation issues, have provided new insights into paediatric muscle strength development. Strength testing of children is performed routinely by researchers to monitor the determinants and development of strength throughout childhood, and also by physiotherapists to assess the degree of muscle disability and to diagnose the rate of recovery. It is important for strength test administrators to be equipped with knowledge of the normal age and sex-associated variations in strength and the factors attributable to that variation. Over time, the use of differing techniques to adjust for body size has changed our perspective of the historical concept of the age- and sex-associated differences in muscle strength. Likewise, the development of more sophisticated techniques to determine muscle size and body composition has allowed researchers to explore the factors associated with the development of strength during growth with a greater degree of validity.

Anaesthesia for children is tempered by changes that occur during both growth and development. Drug dose is affected by size and clearance maturation processes as well as the changing body composition that occurs with age. All organ systems undergo these maturation changes and most are complete within the first few years of life. Normal physiological variables in infancy and childhood are quite different from adults. The central nervous, cardiovascular, and respiratory systems are particularly important. Cerebral immaturity and plasticity impacts sensitivity to drugs, pain responses, and behaviour and increases potential harm from apoptosis with anaesthesia. The heart undergoes a transition from fetal to adult circulation during the first few weeks of life. Undiagnosed congenital defects are not uncommon. The neonate is very susceptible to conditions that trigger an increase in pulmonary vascular resistance, with reversion to fetal circulatory patterns. Respiratory anatomy and mechanics affect the propensity to apnoea, airway maintenance, artificial ventilation modalities, uptake of inhalational agents, and tracheal tube sizes. Metabolic rate and oxygen requirements increase with decreasing age. This physiology influences diverse aspects that include the rate of desaturation during apnoea, hypoglycaemia during starvation, cardiac output, drug metabolism, fluid requirements, and heat production or loss.

This chapter considers the period from the onset of major Muslim military advance to Aurangzeb’s death. In general, the population continued to grow slowly and fitfully. We can only speculate about variation in the rate of population growth. The fourteenth-century Black Death perhaps touched parts of the north-west. But there is no evidence of a major demographic collapse. The seventeenth century, the peak period of Mughal rule, was very challenging—for example, in terms of famines and plague. Nevertheless, the population seems to have grown. Analysts have used deficient data, for example on the cultivated land area, to try to estimate the size of India’s population c.1595. Considering previous work, a figure of 125 million seems a reasonable compromise. However, given the inadequate nature of the data, this number is very far from firm. Previous research appears to have overstated the size of Mughal cities and the accompanying level of urbanization.

This article reviews some of the historic evidence on the evolution of British society, as changes in its structure impacted on the rise of the novel. It considers: (1) Demographic issues, including the size and age composition of the population, factors affecting the mortality rate, the growth in urbanism, and the professions; (2) The economic make-up of society and ways in which the class system operated through the ownership of land and the occupational spread of British people; (3) Issues of gender, as affected by rank, with the limitations and the changing possibilities for women in this era; (4) Writers and readers of the early novel, touching on the growth of literacy, the shifting dynamics of the reading public, the development of the book trade, and the opportunities for professional authors thrown up as patronage declined by new forms of distribution and delivery such as the circulating library.

Until the early 1970s, the United States and Canada both had relatively stable imprisonment rates. This paper uses Canada’s continued stability in its rate of incarceration since this period to develop two intertwined explanations for the growth in US imprisonment between 1973 and 2010. First, using data on the relative size of the growth in imprisonment of the individual states, it presents findings that suggest that increased imprisonment was intimately linked to underlying social values. For instance, those states with the largest increases in incarceration were, in terms of the values of their citizens, least “Canadian-like.” In addition, high imprisonment states tended to have values favoring social exclusion. Second, we argue that the United States has consistently demonstrated penal optimism—that is, a strong faith in the ability of the criminal justice system to reduce crime. Prior to the mid-1970s, it was broadly believed that the recourse to prison through a rehabilitation model whereby offenders were treated or “cured” could reduce crime. Starting in the mid-1970s, the focus of optimism changed such that crime was now seen as being able to be controlled through the deterrent and incapacitative effects of high imprisonment. In contrast, from the mid-nineteenth century onwards, Canada has never been optimistic that the criminal justice system—through any mechanism—could have a substantial impact on crime rates. By extension, imprisonment was seen as a necessary evil to be minimized as much as possible.

Framboids may be the most astonishing and abundant natural features you have never heard of. These microscopic spherules of golden pyrite consist of thousands of even smaller microcrystals, often arranged in stunning geometric arrays. There are probably 10³⁰ on Earth, and they are forming at a rate of 10²⁰ every second. This means that there are a billion times more framboids than sand grains on Earth, and a million times more framboids than stars in the observable universe. They are all around us: they can be found in rocks of all ages and in present-day sediments, soils, and natural waters. The sulfur in the pyrite is mainly produced by bacteria, and many framboids contain organic matter. They are formed through burst nucleation of supersaturated solutions of iron and sulfide, followed by limited crystal growth in diffusion-dominated stagnant sediments. The framboids self-assemble as surface free energy is minimized and the microcrystals are attracted to each other by surface forces. Self-organization occurs through entropy maximization, and the microcrystals rotate into their final positions through Brownian motion. The final shape of the framboids is often actually polygonal or partially facetted rather than spherical, as icosahedral microcrystal packing develops. Their average diameter is around 6 microns and the average microcrystal size is about 0.1 microns. There is no significant change in these dimensions with time: the framboid is an exceptionally stable structure, and the oldest may be 2.9 billion years old. This means that they provide samples of the chemistry of ancient environments.

Management of patients with autosomal dominant polycystic kidney disease (ADPKD) currently comprises non-specific measures including promotion of healthy lifestyle, optimization of blood pressure control, and modification of cardiovascular risk factors. A high water intake of 3–4 L per day in patients with glomerular filtration rate greater than 30 mL/min/1.73 m2 may decrease the risk of kidney stones, but its potential benefit in reducing renal cyst growth is presently unproven. Maintenance of a target blood pressure of 130/80 mmHg is recommended by expert clinical guidelines though this is unlikely to slow cyst growth. It is unclear whether pharmacological blockade of the renin–angiotensin axis confers an extrarenal protective effect. Recognition of the variable clinical presentations of cyst infection, cyst haemorrhage, or nephrolithiasis is important for early diagnosis and optimal management of these complications. Most patients with ADPKD do well on dialysis and after transplantation. Nephrectomy may be needed to make space for a donor kidney, or if kidney size or infection is an issue after end-stage renal failure is reached. Recent advances in ADPKD have led to the identification of multiple potential therapeutic targets with more than 10 clinical trials completed or currently in progress. Given the promising results of the TEMPO trial, tolvaptan may well be the first disease-modifying drug to be approved for clinical use. Several other classes of drugs (e.g. somatostatin analogues, triptolide, metformin, and glucosylceramide synthase inhibitors) with good long-term safety profiles are promising candidates which may be repurposed for this disease. In the future, identifying patients with different risks of renal disease progression by their genotype and/or kidney volume will likely assume an important role for the clinical management of ADPKD.

Latin America and the Caribbean, unlike other regions, is still quite young demographically: people over age 60 make up around 11% of the total population. However, the region is expected to experience the fastest rate of population aging in the world over the coming decades. This projected growth of the elderly population raises challenges related to pensions, health, and long-term care. At the same time, it opens up numerous business opportunities in different sectorshousing, tourism, care, and transportation, for examplethat could generate millions of new jobs. These opportunities are termed the “silver economy,” which has the potential to be one of the drivers of post-pandemic economic recovery. Importantly, women play key roles in many areas of this market, as noted in the first report published by the IDB on this subject (Okumura et al., 2020). This report maps the actors whose products or services are intended for older people and examines silver economy trends in the region by sector: health, long-term care, finance, housing, transportation, job market, education, entertainment, and digitization. The mapping identified 245 actors whose products or services are intended for older people, and it yielded three main findings. The first is that the majority of the actors (40%) operate in the health and care sectors. The prevalence of these sectors could be due to the fact that they are made up of many small players, and it could also suggest a still limited role of older people in active consumption, investment, and the job market in the region. The second finding is that 90% of the silver economy actors identified by the study operate exclusively in their countries of origin, and that Mexico has the most actors (47), followed by the Southern Cone countriesBrazil, Chile, and Argentinawhich have the regions highest rates of population aging. The third finding is that private investment dominates the silver economy ecosystem, as nearly 3 out of every 4 actors offering services to the elderly population are for-profit enterprises. The sectors and markets of the silver economy differ in size and degree of maturity. For example, the long-term care sector, which includes residential care settings, is the oldest and has the largest number of actors, while sectors like digital, home automation, and cohousing are still emerging. Across all sectors, however, there are innovative initiatives that hold great potential for growth. This report examines the main development trends of the silver economy in the region and presents examples of initiatives that are already underway. The health sector has a wealth of initiatives designed to make managing chronic diseases easier and to prevent and reduce the impact of functional limitations through practices that encourage active aging. In the area of long term careone of the most powerful drivers of job creationinitiatives to train human resources and offer home care services are flourishing. The financial sector is beginning to meet a wide range of demands from older people by offering unique services such as remittances or property management, in addition to more traditional pensions, savings, and investment services. The housing sector is adapting rapidly to the changes resulting from population aging. This shift can be seen, for example, in developments in the area of cohousing or collaborative housing, and in the rise of smart homes, which are emerging as potential solutions. In the area of transportation, specific solutions are being developed to meet the unique mobility needs of older people, whose economic and social participation is on the rise. The job market offers older people opportunities to continue contributing to society, either by sharing their experience or by earning income. The education sector is developing solutions that promote active aging and the ongoing participation of older people in the regions economic and social life. Entertainment services for older people are expanding, with the emergence of multiple online services. Lastly, digitization is a cross-cutting and fundamental challenge for the silver economy, and various initiatives in the region that directly address this issue were identified. Additionally, in several sectors we identified actors with a clear focus on gender, and these primarily provide support to women. Of a total of 245 actors identified by the mapping exercise, we take a closer look at 11 different stories of the development of the silver economy in the region. The featured organizations are RAFAM Internacional (Argentina), TeleDx (Chile), Bonanza Asistencia (Costa Rica), NudaProp (Uruguay), Contraticos (Costa Rica), Maturi (Brazil), Someone Somewhere (Mexico), CONAPE (Dominican Republic), Fundación Saldarriaga Concha (Colombia), Plan Ibirapitá (Uruguay), and Canitas (Mexico). These organizations were chosen based on criteria such as how innovative their business models are, the current size and growth potential of their initiatives, and their impact on society. This study is a first step towards mapping the silver economy in Latin America and the Caribbean, and the hope is to broaden the scope of this mapping exercise through future research and through the creation of a community of actors to promote the regional integration of initiatives in this field.