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Dissertations / Theses on the topic 'Tumoren. Angiogenese. Inhibitie'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Schaft, Daisy W. J. van der. "Development of novel angiogenesis inhibitors for cancer treatment." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2002. http://arno.unimaas.nl/show.cgi?fid=7130.

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2

Niwano, Mototaka. "The Inhibition of Tumor Growth and Microvascular Angiogenesis by the Potent Angiogenesis inhibitor, TNP-470 in Rats." Kyoto University, 1998. http://hdl.handle.net/2433/156992.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第7486号<br>医博第2039号<br>新制||医||697(附属図書館)<br>UT51-98-U153<br>京都大学大学院医学研究科分子医学系専攻<br>(主査)教授千葉勉, 教授山岡義生, 教授今村正之<br>学位規則第4条第1項該当

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3

Vitaliti, Alessandra. "Inhibition of tumor induced angiogenesis /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13409.

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4

Åkerman, Maria E. "Targeting and inhibiting tumor angiogenesis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3166405.

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5

Zieher, Heike. "Untersuchungen des Einflusses von Inhibitoren der Angiogenese und ionisierender Bestrahlung auf das Wachstumsverhalten solider Tumoren in vivo." Giessen : VVB Laufersweiler, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4714/index.html.

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6

Escuin, i. Borràs Daniel. "Novel mechanistic link between microtubule disruption and inhibition of tumor angiogenesis." Doctoral thesis, Universitat Autònoma de Barcelona, 2004. http://hdl.handle.net/10803/4458.

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L'angiogènesis, el desenvolupament de nous vasos sanguinis a partir de vasculatura preexistent, és un procés complex que involucra múltiples productes gènics expressats per diferents tipus cel.lulars, i tots ells contribueixen a una seqüència integrada de fenòmens. L'angiogènesis és necessària per tal de permetre el creixement tumoral més enllà d'una certa mida. La hipòxia, un fenomen inherent en els tumors, és un dels factors principals que desencadena el procés angiogènic. En concordança amb el fet que la hipòxia juga un paper clau en tot el procés, un nombre elevat de gens involucrats en di

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7

Liu, Minghui. "Gene Therapy with Interferon Alpha and the Angiogenic Inhibitor, Vasostatin, in Neuroendocrine Tumors of the Digestive System." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7453.

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8

Thulin, Åsa. "The Role of Histidine-rich Glycoprotein in Angiogenesis and Tumor Growth." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110829.

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Histidine-rich glycoprotein (HRG) is a heparin-binding plasma protein modulating immune, hemostatic and vascular functions. I have studied the antiangiogenic functions of HRG in vitro and in vivo in order to understand the molecular mechanisms of action of HRG as an angiogenesis inhibitor. Angiogenesis is the formation of new blood vessels from the pre-existing vasculature. It is a central rate-limiting step of tumor development and thus a possible target for cancer therapeutics. Previous studies have shown that HRG has antiangiogenic functions in vivo and that the antiangiogenic effects are m

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9

Tachijian, Nataly. "The effect of deactivation or silencing of tumor stroma with angiogenesis inhibitor on malignancy of tumor metastases." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445622.

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Background: Neuroblastoma (NB) is a pediatric tumor in infants and young children. The survival rate is only around 50 percent for high-risk NB despite advanced and intense multi-modal therapy. Current research aims to find new effective treatment additional to modern therapy to improve prognosis of high-risk NB in children. As such, SU11248 may be a valuable approach for improving treatment and survival as growth factors have crucial roles in tumor growth, angiogenesis, and metastasis. Aim: The aim of this investigation was to examine tissues from SU11248 treated and nontreated tumor-bearing

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10

Ischenko, Ivan. "Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-64833.

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11

Lee, Chunsik. "Molecular Mechanisms of Action of Histidine-rich Glycoprotein in Angiogenesis Inhibition." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7217.

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<p>Angiogenesis, de novo synthesis of blood vessels from the pre-existing vasculature, is required both during embryonic development and in pathophysiological conditions. In particular, tumor growth needs new capillary vessels in order to both deliver oxygen and nutrients and to remove toxin and metabolites. Growth of most solid tumors would be restricted to a microscopic size in the absence of neovascularization. Angiogenesis ensues as a result of a shift in the balance between pro- and anti-angiogenic molecules.</p><p>Histidine-rich glycoprotein (HRGP) is a heparin-binding plasma protein. We

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12

Martínez, Høyer Sergio 1983. "Unraveling the molecular mechanisms involved in RCAN-peptide mediated inhibition of calcineurin-NFAT signaling and its potential as an inhibitor of tumor progressions." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/123913.

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The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) proteins constitute a family of endogenous regulators of calcineurin, which play an important role in the modulation of the calcineurin-NFATc pathway. Here, we identifiy a novel protein kinase CK2 dependent mechanism by which the CIC motif of RCAN proteins modulate the final signaling output of the pathway. Moreover, we show that the functional CIC motif of RCANs responsib

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13

Moraes, Natassja Foizer. "O C-terminal da proteína S100A9 murina modula os eventos envolvidos na angiogênese e na progressão tumoral em modelos in vitro." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-09122015-114330/.

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As proteínas S100A8/A9 são expressas em diferentes tipos celulares e quando sozinhas ou complexadas e em baixas concentrações, promoveram proliferação, migração celular e formação de estruturas capilares. Por outro lado, quando em altas concentrações, esse complexo inibe o crescimento de diversos tipos de células tumorais murinas e humanas. Ainda, tanto a proteína S100A9 humana, quanto um peptídeo sintético idêntico a porção C-terminal da proteína S100A9 murina (pS100A9m) possuem efeitos antinociceptivo e imunorregulatório. Apesar dessas evidencias, até o momento não foi investigado o efeito d

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14

Castan, Agnès. "Inhibition de l'angiogenèse tumorale : criblage d'une chimiothèque et caractérisation d'un nouveau composé agissant sur la voie de signalisation Ras-ERK." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV017/document.

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Au cours des dernières années, des thérapies anti-cancéreuses ciblant l'angiogenèse tumorale ont été développées et ont démontré un bénéfice en terme de survie globale pour les patients atteints de certains cancers métastatiques. Cependant, dans de nombreux cas, les tumeurs acquièrent des résistances échappent au traitement. Le développement de nouveaux composés anti-angiogène est donc une réelle nécessité pour être proposés en seconde ligne thérapeutique. Dans ce travail, notre objectif était d'identifier de nouvelles molécules anti-angiogènes par le criblage à haut débit, de la chimiothèque

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15

Al-Lakkis, Mira. "Application des dérivés d'amino-benzosubérone : inhibition sélective des aminopeptidases mono ou bimétalliques." Phd thesis, Université de Haute Alsace - Mulhouse, 2012. http://tel.archives-ouvertes.fr/tel-01060176.

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Les aminopeptidases sont des cibles thérapeutiques importantes pour plusieurs maladies, car elles sont impliquées dans divers processus physiologiques et pathologiques comme la progression tumorale, l'angiogenèse, et certaines infections (virales, bactériennes, et parasitaires). Il en existe deux classes : les aminopeptidases avec un ion métallique (Aminopeptidase N [APN ou CD13] et leukotrien A4 hydrolase [LTA4H]) et les aminopeptidases avec deux ions métalliques (Aminopeptidase de l'Aeromonas proteolytica [APaero], Leucine Aminopeptidase cytosolique [LAPc] et Méthionine aminopeptidase 1 ou 2

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16

Cuny, Thomas. "New regulatory mechanisms in the growth of endocrine tumors : digestive neuroendocrine tumors, pitiutary adenomas." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5061.

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Bien que rares, les tumeurs endocrines développées chez l'Homme demeurent problèmatiques. Une meilleure compréhension des mécanismes qui régulent leur croissance constitue un objectif essentiel pour identifier des cibles thérapeutiques nouvelles.Dans la première partie de cette thèse, nous avons étudié l'impact du microenvironnement tumoral (MeT), définit par l'ensemble des facteurs qui encerclent la niche tumorale primitive, sur la croissance des tumeurs endocrines digestives. In vitro, nous observons un effet prolifératif réciproque entre des fibroblastes, l'une des cellules pivots du MeT, e

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17

Walter, Thomas. "Métastases hépatiques de tumeurs endocrines digestives : développement de modèles animaux pour l’étude des mécanismes biologiques et l’évaluation préclinique des thérapeutiques." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10241.

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Les métastases hépatiques de tumeurs endocrines digestives sont hypervasculaires et hétérogènes. Les mécanismes de développement de ces métastases hépatiques, en particulier le rôle de l’angiogenèse tumorale associée à ces tumeurs, sont complexes. Ceci explique la difficulté de prédire le profil évolutif de ces tumeurs et de trouver des facteurs prédictifs de réponses aux traitements médicaux utilisés. L’objectif de notre travail a été de mieux comprendre : le rôle de l’angiogenèse dans le développement des métastases hépatiques de tumeurs endocrines digestives ; les mécanismes d’actions et en

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18

Cai, Chengzhong [Verfasser], and Robert [Akademischer Betreuer] Mandic. "Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis / Chengzhong Cai ; Betreuer: Robert Mandic." Marburg : Philipps-Universität Marburg, 2012. http://d-nb.info/1194161979/34.

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19

Hardcastle, Jayson James. "Vstat120 modulates inhibits oncolytic viral therapy induced angiogenesis and innate pro-inflamatory response, augmenting oncolytic viral thereapy of glioblastom multiforme." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305920551.

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20

Mei, Szu-Chieh, and 梅思潔. "Studies on the Inhibitor of Tumor Angiogenesis." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/su525s.

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博士<br>國立陽明大學<br>生物藥學研究所<br>96<br>Thalidomide is an old drug with a wide variety of molecular mechanisms. Many clinical data showed that thalidomide has anti-angiogenic activity and the responder showed a significant decrease of serum bFGF level after treatment. Since bFGF is an important factor for regulating limb development, the teratogenic activity of thalidomide may also be accounted by its decrease of bFGF level. In this study, by using low dose treatment, we found that thalidomide can diminish bFGF level in cell. Thalidomide suppressed the transcription and translation of bFGF gene throu

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21

Young, Ja-Wen, and 楊介文. "The studies on the inhibitor of tumor angiogenesis." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/13941183468041139959.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>91<br>Abstract: Currently strategies of cancer therapy are based on chemotherapy. Because of the cytotoxicity on normal cells, there is a bottleneck in the development of traditional cancer therapy. Folkman J. proposed anti-tumor angiogenesis at 1971, and the new concept offer novel strategies of cancer therapy. Thalidomide originally developed as an anti-morning sickness drug, but had been terminated clinically used because of its teratogenic effect. Thalidomide has been previously shown to inhibit angiogenesis induced by basic fibroblast growt

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22

Lin, Tzu-Han, and 林子涵. "A novel action mechanism for MPT0E028, a HDAC inhibitor, inhibits tumor angiogenesis in vitro and in vivo." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/60513977022203743322.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>103<br>Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels and is also a normal and vital process in growth and development, wound healing, formation of granulation tissue as well as tumor proliferation and metastasis. It has been reported that histone deacetylase inhibitors (HDAC inhibitors) are a novel class of small molecular anticancer agents through modulating the acetylation/deacetylation of histones and/or non-histone proteins and therefore altering the expression of oncogenes or tumor suppressors. MPT0E0

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23

Hsiao, Jung-Han, and 蕭容函. "Combination Curcuminoids with Semaxanib Synergistically Inhibited Tumor Angiogenesis and Metastasis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/63te47.

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24

Chen, Yu-cheng, and 陳昱丞. "Inhibition of Angiogenesis and Tumor Growth of B16/F10 with A Novel VEGF Receptor Antagonist in vivo." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/34702139296048942095.

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碩士<br>國立交通大學<br>生化工程研究所<br>96<br>Angiogenesis is not just an important stage in tumor growth but also involved in transforming a tumor from a benignancy to a malignant stage. Vascular endothelial growth factor (VEGF) is an essential factor in promoting endothelial cell growth and angiogenesis. In our previous experiments, we created a novel fusion protein, RBDV-Ig, which has a targeting domain, containing the amino acid sequences of VEGF from 1 to 108 with the binding activity to the human VEGF receptor, and an effector domain with Fc region of a human IgG1, used to increase a half-life of the

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25

Hsu, Ming-Jie, and 許名傑. "Lupeol inhibits tumor angiogenesis and metastasis in human osteosarcoma U-2 OS cells through p38 MAPK pathway." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/j3k9x7.

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26

Hsiao, Fu-Ching, and 蕭富擎. "Hispolon Inhibits Angiogenesis By Suppressing Vascular Endothelial Growth Factor Signaling Pathway And induces Prostate Tumor Cell apoptosis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/82330016299966227600.

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碩士<br>中國醫藥大學<br>中國藥學研究所碩士班<br>97<br>Phellinus linteus (PL) , is a traditional medicinal plant of oriental people (especially in China, Japan,and North Korea ) , was demonstrated to exhibit anti-bacterial , anti-tumour , anti-fibrotic , anti-oxidant and anti-inflammation functions in several studies. Hispolon is a major component of PL with great antioxidant activity. Whether Hispolon induces prostate tumor cell apoptosis or inhibits angiogenesis,which is crucial for cancer and other human diseases, remains unknown. First, we investigated how hispolon induce apoptosis in the prostate tumor ce

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27

Ischenko, Ivan [Verfasser]. "Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer / vorgelegt von Ivan A. Ischenko." 2007. http://d-nb.info/983455457/34.

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28

Hsueh, Shu-Ping, and 薛淑萍. "SV40 T/t-common polypeptide inhibits angiogenesis and enhances the cytotoxic activity of chemotherapeutic agents in human HER2-overexpressing tumors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/57959984650785599184.

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博士<br>國立臺灣大學<br>微生物學研究所<br>100<br>Overexpression of HER2 has been frequently detected in many types of human cancer, most notably breast and ovarian cancers. HER2 overexpression is associated with increased angiogenesis, increased metastasis, increased chemoresistance and reduced survival. Inhibition of HER2 in HER2-overexpressing cancers can lead to reduced angiogenesis, reduced chemoresistance and improved survival. Previously, we reported that Simian Virus 40 T/t-common polypeptide can inhibit HER2, suppress the tumorigenic potential of HER2-overexpressing cancer cells and specifically indu

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29

Curtis, VF, H. Wang, P. Yang, et al. "A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer." Thesis, 2013. http://hdl.handle.net/10161/4982.

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Infiltration of myeloid cells in the tumor microenvironment is often associated with enhanced angiogenesis and tumor progression, resulting in poor prognosis in many types of cancer. The polypeptide chemokine PK2 (Bv8, PROK2) has been shown to regulate myeloid cell mobilization from the bone marrow, leading to activation of the angiogenic process, as well as accumulation of macrophages and neutrophils in the tumor site. Neutralizing antibodies against PK2 were shown to display potent anti-tumor efficacy, illustrating the potential of PK2-antagonists as therapeutic agents for the treatment of c

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30

"Determination of the biological significances of platelet factor 4 (PF4), a tumor suppressor gene encoding an angiogenesis inhibitor in multiple myeloma." 2012. http://library.cuhk.edu.hk/record=b5549446.

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多發性骨髓瘤(Multiple myeloma) 為骨髓內漿細胞異常增生的惡性腫瘤，到目前為止仍然難以治癒。其發生發展是一個複雜的多步驟事件，涉及腫瘤細胞中遺傳和表觀遺傳的改變，以及骨髓微環境的支持。現已確定骨髓瘤細胞和骨髓微環境之間的相互作用對於骨髓瘤的病理發生，以及骨髓瘤細胞的生長，遷移和抗藥性起著關鍵作用。血小根因子四(Platelet factor 4, or PF4) 是一種抗血管生成的趨化因子。它不僅在體外抑制血管內皮細胞增殖和遷移，而且在體內抑制腫瘤的生長。此前，我們發現PF4 基因在多發性骨髓瘤中等位缺失以及DNA 高度甲基化，因而導致其在骨髓瘤病人及細胞系中的表達缺失或降低。在本研究中，我們利用體內和體外實驗鑒定了PF4 對骨髓瘤細胞以及血管生成的作用，並闡明了其作用機制。<br>首先，我們在體外鑒定了PF4 在骨髓瘤細胞中的功能。我們發現PF4 抑制骨髓瘤細胞系以及從病人骨髓中分離出來的骨髓瘤細胞的生長，以及促進其凋亡。其促凋亡活性與caspase-3 和PARP 的激活有關。我們也檢測了PF4 在骨髓瘤中對血管生成的作用。我們首先分離了病人骨髓中的內皮細胞。結果顯示PF4抑制骨髓瘤內皮細胞的生長和管狀物的形成。這些結果證明PF4 在骨髓瘤中可能是一個抑癌因子。<br>接下來我們進一步檢測了PF4 在體內的抑癌功能。在第一種模型中，骨髓瘤細胞被皮下移植到重症聯合

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