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1

Kushida, Michelle Mayumi. Identification of CIS-active targets of MHC class 1 transcritional downregulaton in tumour cells. National Library of Canada, 1996.

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2

Bates, P. I. Radiosynthesis and biological studies with platinum and carbon labelled JM216: An orally active platinum anti-tumour complex. UMIST, 1996.

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3

Orentas, Rimas. Cancer vaccines and tumor immunity. Wiley-Interscience, 2008.

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4

service), SpringerLink (Online, ed. Innate and Adaptive Immunity in the Tumor Microenvironment. Springer Science + Business Media, LLC, 2008.

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5

Ilgren, E. B. Mesotheliomas of animals: A comprehensive, tabular compendium of the world's literature. CRC Press, 1993.

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6

1950-, Morstyn George, Foote MaryAnn, and Lieschke Graham J, eds. Hematopoietic growth factors in oncology: Basic science and clinical therapeutics. Humana Press, 2004.

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7

C, Dale David, and SpringerLink (Online service), eds. Hematopoietic Growth Factors in Oncology. Springer Science+Business Media, LLC, 2011.

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8

Gen, Sobue, and New York Academy of Sciences, eds. Integrated molecular medicine for neuronal and neoplastic disorders. Blackwell Pub. on behalf of the New York Academy of Sciences, 2006.

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9

Tamoxifen: Molecular basis of use in cancer treatment and prevention. J. Wiley & Sons, 1994.

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10

L, Spitzer Hugh, ed. Receptor-mediated biological processess: Implications forevaluating carcinogenesis : proceedings of the Sixth International Conference on Carcinogenesis and Risk Assessment, held in Austin, Texas, on December 8-11, 1992. Wiley-Liss, 1994.

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11

J, Vinken P., Bruyn G. W, and Wolff F. A. de, eds. Intoxications of the nervous system. Elsevier Science, 1994.

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12

Faddegon, Stephen, Ephrem O. Olweny, and Jeffrey A. Cadeddu. Ablative technologies for renal cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0087.

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Nearly two-thirds of newly detected renal masses are clinical stage 1, with T1a tumours accounting for 60% of the newly detected stage 1 tumours. Guideline panels convened by the American Urological Association and the European Association of Urology recommend nephron-sparing surgery as the gold standard treatment for small renal masses, with active surveillance and thermal ablation recommended as alternative strategies in select patients. However, there is a dearth of studies directly comparing outcomes for energy-based ablation to those for traditional surgical treatments for small renal mas
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13

Laws, Edward R., Whitney W. Woodmansee, and Jay S. Loeffler. Pituitary tumours. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0018.

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Pituitary tumours are common, usually benign, lesions ordinarily well controlled by multidisciplinary management. The several subtypes of pituitary tumours reflect the hormones produced by the pituitary gland, and each may require a complex sequential programme of treatment. Modern laboratory evaluation and imaging is capable of extensively characterizing the tumours, and is the basis for the recommended therapies. The tumours that produce excess active levels of pituitary hormones may be amenable to very satisfactory medical therapy, which reduces hormone levels towards normal, and often caus
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14

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, Gareth Morris-Stiff, and Madhumita Bhattacharyya. Gynaecological cancers. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0020_update_001.

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Genitourinary cancers examines the malignancies arising in the kidney, ureter, bladder, prostate, testis, and penis. Renal cancer has high propensity for systemic spread, largely mediated by overexpression of vascular endothelial growth factor (VEGF). Treatments include surgery, immunotherapy, and targeted therapy. Wilms tumour, a childhood malignancy of the kidney, warrants specialist paediatric oncology management to provide expertise in its unique pathology, staging, and treatment, often with surgery and chemotherapy. Cancer of the bladder and ureters, another tobacco related cancer, may pr
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15

Joniau, Steve, S. Van Bruwaene, J. Karnes, et al. High-risk prostate cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0066.

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In this chapter, patients with adverse tumour characteristics and a high risk of tumour progression are discussed. In the current era of PSA testing, the proportion of patients presenting with high-risk prostate cancer (PCa) is estimated between 10% and 20% with a 10-year cancer specific survival approaching 40% for those not receiving active local treatment. The prevalence of high-risk disease varies with community PSA use, and is higher in countries (e.g. 30% in the United Kingdom) with little PSA testing. Adequate staging with magnetic resonance imaging for tumour extension, computer tomogr
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16

Raheja, Amol, and William T. Couldwell. Endocrine Active Pituitary Tumor. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0015.

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This chapter presents an illustrative case demonstrating the principles of diagnosis and management in endocrine active pituitary tumor. The index case involves a 30-year-old male patient who presented with phenotypic markers of acromegaly. On radiological and endocrinological evaluation, growth hormone–secreting pituitary macroadenoma was identified. The philosophy of decision-making and management paradigm is discussed to demonstrate the pros and cons of medical, radiation, and surgical options. Technical nuances of the surgical procedure and its complication management are stressed. A brief
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17

Keshav, Satish, and Alexandra Kent. Gastrointestinal tumours. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0204.

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Gastrointestinal (GI) tumours can affect any part of the GI tract, and colorectal cancer is the most common. Throughout the GI tract, chronic inflammation seems to promote the development of neoplasia: for example, chronic reflux oesophagitis is linked to oesophageal adenocarcinoma; chronic Helicobacter pylori infection is linked to gastric cancer; chronic pancreatitis is linked to pancreatic cancer; cirrhosis is linked to hepatocellular cancer; chronic biliary inflammation is linked to cholangiocarcinoma; untreated coeliac disease is linked to intestinal lymphoma; and chronic inflammatory bow
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18

Connor, Thomas, and Patrick H. Maxwell. Von Hippel–Lindau disease. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0332.

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Von Hippel–Lindau (VHL) disease is a dominantly inherited familial cancer syndrome caused by germline mutations in the VHL tumour suppressor gene. The most frequent manifestations of VHL disease are retinal and central nervous system haemangioblastomas, clear cell renal cell carcinomas, and phaeochromocytomas. Genetic testing and active screening for clinical manifestations is now started in childhood and has greatly improved the prognosis for patients with VHL disease. The VHL protein plays a critical role in regulating the cellular response to changes in oxygen tension. Loss of VHL function
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19

Taylor, Jennie W., and Scott R. Plotkin. Familial CNS Tumor Syndromes. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0135.

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Neurofibromatosis type 2 (NF2) is a genetic disorder caused by constitutional mutations in the NF2 tumor-suppressor gene. Bilateral vestibular schwannomas are the hallmark of the syndrome, though meningiomas, ependymomas, and other peripheral schwannomas are common. Inheritance is autosomal dominant and de novo mutations are found in about 50% of patients. Standard treatment for symptomatic tumors is surgery. Radiation therapy may be considered for progressive tumors that are not surgically accessible, but secondary cancers after radiation have been reported. Retrospective studies suggest that
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20

Mathe, G. Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration. Springer, 2012.

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21

Mathe, G. Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration. Springer Berlin / Heidelberg, 2012.

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22

Eisen, Tim. The patient with renal cell cancer. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0172.

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Renal cancer is the commonest malignancy of the kidney and worldwide, accounts for between 2% and 3% of the total cancer burden. The mainstay of curative treatment remains surgery. There have been significant advances in surgical technique, the most important ones being nephron-sparing surgery and laparoscopic nephrectomy. The medical treatment of advanced renal cell cancer has only improved markedly in the last decade with the development of antiangiogenic tyrosine-kinase inhibitors, inhibitors of mammalian target of rapamycin, and a diminished role for immunotherapy.Tyrosine-kinase inhibitor
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23

Orentas, Rimas, James W. Hodge, and Bryon D. Johnson. Cancer Vaccines and Tumor Immunity. Wiley & Sons, Incorporated, John, 2009.

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24

Rimas, Orentas, Hodge James W, and Johnson Bryon D, eds. Cancer vaccines and tumor immunity. John Wiley & Sons, 2008.

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25

Orentas, Rimas, James W. Hodge, and Bryon D. Johnson. Cancer Vaccines and Tumor Immunity. Wiley & Sons, Incorporated, John, 2007.

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26

Cancer Vaccines and Tumor Immunity. Wiley-Liss, 2008.

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27

Bruce, Wesley Bernard. Characterization of functional domains of a T-DNA promoter active in sunflower tumors. 1987.

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28

Grant, Warren, and Martin Scott-Brown. Principles of oncogenesis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0322.

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It is obvious that the process of developing cancer—oncogenesis—is a multistep process. We know that smoking, obesity, and a family history are strong independent predictors of developing malignancy; yet, in clinics, we often see that some heavy smokers live into their nineties and that some people with close relatives affected by cancer spend many years worrying about a disease that, in the end, they never contract. For many centuries scientists have struggled to understand the process that make cancer cells different from normal cells. There were those in ancient times who believed that tumo
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29

Sieper, Joachim. Ankylosing spondylitis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0113.

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Ankylosing spondylitis (AS) is a chronic inflammatory disease predominantly of the sacroiliac joint (SIJ) and the spine. It starts normally in the second decade of life and has a slight male predominance. The prevalence is between 0.2 and 0.8% and is strongly dependent on the prevalence of HLA B27 in a given population. For the diagnosis of AS, the presence of radiographic sacroiliitis is mandatory. However, radiographs do not detect active inflammation but only structural bony damage. Most recently new classification criteria for axial spondyloarthritis (SpA) have been developed by the Assess
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30

Sieper, Joachim. Axial spondyloarthropathies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0113_update_003.

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Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly of the sacroiliac joint (SIJ) and the spine. It starts normally in the second decade of life and has a slight male predominance. The prevalence is between 0.2% and 0.8% and is strongly dependent on the prevalence of HLA-B27 in a given population. AxSpA can be split in patients with radiographic axSpA (also termed ankylosing spondylitis (AS)) and in patients with non-radiographic axSpA (nr-axSpA). For the diagnosis of AS, the presence of radiographic sacroiliitis is mandatory. However, radiographs do not detect acti
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31

Weller, Michael, Michael Brada, Tai-Tong Wong, and Michael A. Vogelbaum. Astrocytic tumours: diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, and gliomatosis cerebri. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0003.

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Astrocytic gliomas are primary brain tumours thought to originate from neural stem or progenitor cells. They are assigned grades II, III, or IV by the World Health Organization according to degree of malignancy as defined by histology. The following molecular markers are increasingly used for diagnostic subclassification or clinical decision-making: 1p/19q co-deletion status, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, and isocitrate dehydrogenase 1 and 2 mutation status. Extent of resection is a favourable prognostic factor, but surgery is never curative. Radiot
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32

Hellman, Samuel. Research. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190650551.003.0004.

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Research is an integral part of the author’s academic life. His clinical research began with how best to combine surgery, radiation, and chemotherapy to increase tumor cure. Since these modalities had different mechanisms of action as well as different toxicities and limitations, combining them offered the potential of more effective and less morbid treatments. While he began these studies with Hodgkin and other lymphomas, breast cancer was a major emphasis throughout his career. Lymphoma treatment has improved greatly, resulting in marked increases in cure rates. Breast cancer treatment now i
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33

Nikravan, Sara, and Frederick Mihm. Pathophysiology and management of functional endocrine tumours in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0264.

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Thyroid hormones act on most tissues via nuclear T3 receptors. Thyroid hormones stimulate oxygen consumption and heat production, influence cell growth and maturation (central nervous system, bone), and modulate metabolism (carbohydrates, lipids, proteins, drugs). Treatment for presumed thyroid disease frequently has to be initiated before the results of diagnostic tests are available. Treatment of hyperthyroidism should result in the reduction of serum thyroid hormone levels and their action on peripheral tissues with concurrent treatment of the precipitating event. In severe hypothyroidism t
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34

Rossor, Martin. Coma. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0749.

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Many pathological processes can be responsible for stupor or coma, for example, head injury, tumour, vascular and inflammatory lesions, and most commonly toxic and metabolic states which usually lead to unconsciousness primarily through their effect upon the brainstem. In the series of Plum and Posner (1980) of 500 cases of stupor or coma, initially of unknown aetiology, 101 proved to be due to supratentorial lesions probably producing their effects by indirect action upon the brainstem, 65 to subtentorial lesions, and 326 to diffuse or metabolic brain.
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35

Close, Frank. 8. Applied nuclear physics. Oxford University Press, 2015. http://dx.doi.org/10.1093/actrade/9780198718635.003.0008.

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Nuclear physics is a rich and active field. The large amounts of latent energy within the nuclei of atoms can be liberated in nuclear reactors. Together with nuclear weapons, this is the most familiar application of nuclear physics, but ‘Applied nuclear physics’ provides a summary of other applications to industry, medical science, and human health. The phenomenon of natural radioactivity provides beams of particles, which may be used to initiate other nuclear reactions, or to attack tumours in cancer treatment. Forensics via induced radioactivity, nuclear magnetic resonance imaging (NMRI), an
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36

Bran, Eduardo López. Estudio Del Melanoma B16 Trasplantado en Su Portador Singenico el Ratón 657Bl/6J. Inmunoterapia Es Pecífica Activa Polivalente en Dicho Tumor. Universidad Complutense de Madrid, Servicio de Publicaciones, 2005.

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37

Heidenreich, Axel. Testis cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0092.

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Testicular germ cell tumours represent the most common solid neoplasms in the age group of 20 to 40 years. These cancers have an excellent prognosis, with a 90% long-term survival rate due to well-established, interdisciplinary guidelines for diagnosis and treatment. Independent on the clinical stage at time of diagnosis, treatment after orchidectomy is performed on an individual risk adapted approach. In clinical stage I seminoma, active surveillance is the recommended therapy and adjuvant chemotherapy with carboplatin remains an option in men not suitable for surveillance. Clinical stage IIA
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38

Okita, K. Hcv/Oxidative Stress and Liver Disease. Springer, 2013.

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39

Bawa, Sandeep, Paul Wordsworth, and Inoshi Atukorala. Spondyloarthropathies. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.010004.

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♦ Spondyloarthropathies are related conditions typically associated with axial skeletal involvement, absence of rheumatoid factor, familial clustering, and a variable positive association with HLA-B27♦ Ankylosing spondylitis is the prototype with sacroiliac joint involvement being a prerequisite for diagnosis♦ Diagnosis is frequently delayed for several years but the use of magnetic resonance imaging to detect sacroiliitis greatly facilitates the establishment of an early diagnosis♦ Psoriatic arthritis, reactive arthritis, and enteropathic arthritis have prominent peripheral joint involvement
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40

Gordon-Williams, Richard M., and Anthony H. Dickenson. Pathophysiology of pain in cancer and other terminal illnesses. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0092.

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Cancer pain involves a myriad of peripheral changes in the function of tissue and nerves, at the site of the tumour growth, as well as a number of consequent changes in the processing of pain messages at the spinal cord level with implications for the pain experience at higher centres. This chapter reviews the changes in peripheral pain signalling, notes the likely prevalence of both inflammatory and neuropathic components, and describes the altered events at spinal levels that can come some way towards explaining ongoing pain, hyperalgesia, and allodynias that patients with cancer and other t
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41

Cooperberg, Matthew, and Peter Carroll. Prostate cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0064.

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Management of prostate cancer remains controversial, in large part because of its wide heterogeneity in terms of aggressiveness and prognosis. Early detection efforts based on prostate specific antigen (PSA) and aggressive treatment of high-risk cancers have yielded major improvements in mortality rates, but overtreatment of low-risk cancers—those unlikely to cause symptoms or threaten life if they were never detected—is associated with high rates of avoidable toxicity and cost. Prostate cancer can be effectively risk-stratified based on tools (e.g. nomograms, CAPRA score) integrating the PSA
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42

Freifeld, Alison G. An Introduction. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199938568.003.0100.

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This chapter focuses on solid tumors and how they can be treated. Solid tumors, lymphomas, and leukemias represent a widely diverse array of cancers. Until recently, the general approach to treating all of them was to administer cytotoxic anticancer drugs that damage proliferating cells by interfering with mitosis and other essential steps in cellular replication. Localized solid tumors are largely treated by surgical resection and radiotherapy, with cytotoxic chemotherapy being commonly used adjunctively or in cases of metastatic disease. A major drawback of this approach has been the lack of
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43

Golan, Amos. Advanced Inference in the Real World. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199349524.003.0006.

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In this chapter I continue the voyage into info-metrics in action, with an emphasis on more advanced info-metric inference in real-world environments. I develop a sequence of increasingly complex applications. In the first example, the maximum entropy method is extended for inferring interval information, with an application to weather data. The next example introduces additional conditional information into the constraints. It is a laboratory example, complemented with simulated data matched to observed population frequencies. The last example is the most complex, using surprisal analysis and
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44

Pitt, Matthew. Needle EMG findings in different pathologies. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198754596.003.0007.

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In this chapter, the inability of electromyography (EMG) to be able to further progress the diagnosis of myopathy on its own—requiring muscle biopsy and other modalities such as genetics to complete this process—is emphasized. The role of EMG particularly in the era of genetics is discussed. Findings in neurogenic abnormality are next described and the important hereditary conditions such as spinal muscular atrophy (SMA), distal SMA, Brown–Vialetto–Van Laere syndrome, segmental anterior horn cell disease, conditions with progressive bulbar palsy, SMARD1, and pontocerebellar hypoplasia with spi
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45

Stevens, Philip, and Paul Dark. Ileus and obstruction in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0182.

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Obstruction is the commonest cause of acute intestinal failure in critical care. Management is dependent upon whether it is adynamic or mechanical in origin. Paralytic ileus is managed conservatively by correction of electrolyte disturbances, nutritional support, and minimization of enterostatic drug use. Pharmacological agents aimed at reducing sympathetic stimuli may be useful, although widespread application is limited due to anti-muscarinic side effects. Peripherally acting μ‎-opioid receptor antagonists, may have a role, although data in critical illness are lacking. Prokinetic agents hav
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46

Morstyn, George, MaryAnn Foote, and Graham J. Lieschke. Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics. Humana Press, 2012.

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47

Morstyn, George, MaryAnn Foote, and Graham J. Lieschke. Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics. Humana Press, 2004.

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48

Dale, David C., Gary H. Lyman, and Gary Lyman. Hematopoietic Growth Factors in Oncology. Springer, 2012.

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49

Kiwamu, Okita, ed. HCV/oxidative stress and liver disease. Springer, 2003.

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50

Okita, K. HCV/Oxidative Stress and Liver Disease. Springer London, Limited, 2013.

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