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Dissertations / Theses on the topic 'Tumour active'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Daghriri, Hassan. "Studies on Tumour Active Compounds with Multiple Metal Centres." University of Sydney. Biomedical Sciences, 2004. http://hdl.handle.net/2123/595.

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Four tumour active trinuclear complexes: DH4Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd( NH3)2(H2N(CH2)4NH2)2]Cl4, DH5Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd( NH3)2(H2N(CH2)5NH2)2]Cl4, DH6Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd( NH3)2(H2N(CH2)6NH2)2]Cl4, DH7Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd(NH3)2-( H2N(CH2)7NH2)2]Cl4 and one dinuclear complex DHD: [{trans-PtCl(NH3)2}�-{ H2N(CH2)6NH2}{trans-PdCl(NH3)2]Cl(NO3), have been prepared and characterised based on elemental analyses, IR, Raman, mass and 1 H NMR spectral measurements. For the trinuclear complexes, the synthesis has been carried out using a step

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2

Daghriri, Hassan. "Studies on Tumour Active Compounds with Multiple Metal Centres." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/595.

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Four tumour active trinuclear complexes: DH4Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd( NH3)2(H2N(CH2)4NH2)2]Cl4, DH5Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd( NH3)2(H2N(CH2)5NH2)2]Cl4, DH6Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd( NH3)2(H2N(CH2)6NH2)2]Cl4, DH7Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd(NH3)2-( H2N(CH2)7NH2)2]Cl4 and one dinuclear complex DHD: [{trans-PtCl(NH3)2}�-{ H2N(CH2)6NH2}{trans-PdCl(NH3)2]Cl(NO3), have been prepared and characterised based on elemental analyses, IR, Raman, mass and 1 H NMR spectral measurements. For the trinuclear complexes, the synthesis has been carried out using a step

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3

Tayyem, Hasan. "Studies on new tumour active compounds with one or more metal centres." zConnect to full text, 2006. http://hdl.handle.net/2123/1727.

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Thesis (Ph. D.)--University of Sydney, 2007.<br>Title from title screen (viewed may 17, 2007). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Biomedical Sciences, Faculty of Health Sciences. Degree awarded 2007; thesis submitted 2006. Includes bibliographical references. Also issued in print.

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4

Tayyem, Hasan Mohammad. "Studies on new tumour active compounds with one or more metal centres." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/1727.

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The present study deals with the synthesis, characterization, determination of anticancer activity of three mononuclear trans-planaraminepalladium(II) complexes code named TH5, TH6 and TH7 and three trinuclear complexes code named TH1, TH8 and TH14. The activity of the compounds against human cancer cell lines: A2780, A2780cisR and A2780ZD0473R, cell uptake, DNA-binding and nature of interaction with pBR322 plasmid DNA have been determined. Whereas cisplatin binds with DNA forming mainly intrastrand GG adduct that causes local bending of a DNA strand, TH5, TH6, TH7, TH1 and TH8 bind with DNA f

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5

Tayyem, Hasan Mohammad. "Studies on new tumour active compounds with one or more metal centres." Faculty of Health Sciences, 2006. http://hdl.handle.net/2123/1727.

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Doctor of Philosophy(PhD)<br>The present study deals with the synthesis, characterization, determination of anticancer activity of three mononuclear trans-planaraminepalladium(II) complexes code named TH5, TH6 and TH7 and three trinuclear complexes code named TH1, TH8 and TH14. The activity of the compounds against human cancer cell lines: A2780, A2780cisR and A2780ZD0473R, cell uptake, DNA-binding and nature of interaction with pBR322 plasmid DNA have been determined. Whereas cisplatin binds with DNA forming mainly intrastrand GG adduct that causes local bending of a DNA strand, TH5, TH6, TH7

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6

Subbotina, Beztsinna Nataliia. "Riboflavin-based amphiphiles for tumour-targeted nanosystems." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0254/document.

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La riboflavine (RF) est une vitamine essentielle pour la croissance et le développement cellulaire. Elle possède des propriétés physico-chimiques intéressantes et est internalisée dans les cellules par des transporteurs spécifiques. Le premier objectif de ce projet était de synthétiser des dérivés amphiphiles de la RF (RFA) et d'étudier leurs capacités d'auto-assemblages. Le second objectif était d'insérer les RFA dans des liposomes et d'évaluer leur efficacité de ciblage tumoral in vitro et in vivo. La préparation des différents RFA repose sur l'ajout d'un lipide en différentes positions de l

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7

Lavaud, Mélanie. "Identification des acteurs clés impliqués dans le développement du tissu osseux et l'évolution des ostéosarcomes par études des super-enhancers actifs." Thesis, Nantes Université, 2022. http://www.theses.fr/2022NANU1019.

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Les super-enhancers (SE) correspondent à des groupement d'enhancers qui recrutent le complexe transcriptionnel pour induire la transcription de leurs gènes cibles plus efficacement que les enhancers. Ils régulent des gènes clés définissant l'identité cellulaire dans des conditions physiologiques et pathologiques. Les objectifs de ce projet de thèse étaient de caractériser le développement osseux normal par l'étude des gènes clés de l'ostéoblastogenèse et de l'ostéoclastogenèse et de caractériser l'évolution métastatique de l'ostéosarcome (OS), la tumeur osseuse primitive maligne la plus fréque

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8

Milbank, Edward. "Extracellular vesicles as a therapeutic strategy to prevent or reverse obesity and its metabolic complications in the field of nanomedicine Extracellular vesicles: Pharmacological modulators of the peripheral and central signals governing obesity Microparticles from apoptotic RAW 264.7 macrophage cells carry tumour necrosis factor-a functionally active on cardiomyocytes from adult mice." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0074.

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A ce jour, les thérapies anti-obésité restent limitées. De récente études ont fourni des résultats prometteurs en démontrant une diminution du poids de la souris via une injection stéréotaxique d’une forme dominante négative de l’AMPK (AMPK DN) directement dans le noyau ventromédial hypothalamique (VMH). Cependant, le potentiel thérapeutique de cette thérapie génique se voit entravé par une libération non spécifique de l’AMPK suite à une injection intraveineuse, plus adaptée à une approche clinique. Nous avons donc développé une approche de « nanobiomédecine » en utilisant des exosomes - nanov

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9

Barbara, Jeffrey A. J. "The mechanism of action of tumour necrosis factor-[alpha] /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phb229.pdf.

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10

Roelofs, Anke. "Anti-tumour mechanisms of action bisphosphonates and bisphosphonate analogues." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436994.

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11

Morrow, Dympna Mary Paula. "Tumour promotion : mechanisms of action and modes of prevention." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322414.

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12

Ruddock, Mark William. "The mechanism of action of the selective tumour radiosensitizer nicotinamide." Thesis, University of Ulster, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287132.

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13

Sampson, Louise E. "Investigations into the mechanism of action of tumour necrosis factor." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304660.

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14

Hickman, J. A. "Studies of the mechanism of action of anti-tumour compounds." Thesis, Aston University, 1989. http://publications.aston.ac.uk/21707/.

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15

Sanders, Paul Michael. "Mechanism of action of a tumour derived lipid mobilising factor." Thesis, Aston University, 2003. http://publications.aston.ac.uk/11005/.

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Cancer cachexia comprises unintentional and debilitating weight loss associated with certain tumour types. Fat loss in cachexia is mediated by a 43kDa Lipid Mobilising Factor (LMF) sharing homology with endogenous Zinc-a2-Glycoprotein (ZAG). LMF and ZAG induced significant lipolysis in isolated epidydimal adipose tissue. This is attenuated by co-incubation with 10mM of antagonist SR59230A and partially attenuated by 25mM PD098059 (indicating b3-AR and MAPK involvement respectively). LMF/ZAG induced in vitro lipid depletion in differentiated 3T3-L1 adipocytes that seen to comprise a significant

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16

Darragh, Molly Rose. "Targeting the active serine protease MT-SP1 for tumor detection in vivo." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398875.

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17

Griffiths, Stephen Douglas. "The mechanism of action of interferon-#alpha# in hairy-cell leukaemia." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257124.

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18

Chauchet, Xavier. "Développement d'un vecteur bactérien pour l'immunothérapie anti-tumorale active et spécifique et caractérisation de la réponse immune induite." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENS024/document.

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Malgré les programmes de dépistage mis en place et le vaste arsenal thérapeutique disponible, 8,2 millions de décès dans le monde ont été attribués au cancer pour l'année 2012 (données Globocan 2012, OMS). L'immunothérapie antitumorale est en plein essor et consiste notamment à exploiter le système immunitaire de l'hôte pour obtenir une réponse contre la tumeur. L'utilisation de vecteurs bactériens, capables de délivrer un message antigénique et de stimuler de manière concomittante l'immunité innée, fait partie des approches de vaccination antitumorale prometteuses. Parmi ces vecteurs, une bac

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19

Dupouy-Camet, Anne. "Molécules promotrices de la mélanogénèse." Paris 5, 1989. http://www.theses.fr/1989PA05P211.

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20

Lynch, Eileen Marie. "The effect of oxygen tension on the cytotoxic action of tumour necrosis factor-alpha." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362843.

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21

Komaragiri, Shravan Kumar. "Mechanism of action of ID4 as a tumor suppressor." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2016. http://digitalcommons.auctr.edu/dissertations/3335.

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Initial studies demonstrated that Inhibitor of DNA binding/differentiation protein 4 (Id4) acts as a tumor suppressor in prostate cancer (PCa). To further confirm and investigate the mechanism by which ID4 acts as a tumor suppressor, herein we concentrated on two different approaches. In the first approach we investigated ID4 role as a tumor suppressor by regulating AKT/PI3K pathway. In the second approach, we examined the role ofld4 in blocking the tumorogenic properties of metastatic PC3 cells. Phosphoinositide 3-kinase/Protein kinase B (PB/AKT) pathway regulates multiple biological processe

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22

McHardy, Lianne M. "A study of the mechanism of action of novel inhibitors of tumour cell invasion." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/252.

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Metastasis is the leading cause of death in cancer patients. Tumour invasion and migration are critical aspects of metastatic progression. A forward chemical genetics project was initiated in an effort to identify novel compounds that inhibit tumour invasion. After screening a natural extract library, two novel inhibitors were identified: motuporamine C (MotC) and strongylophorine-26 (STP-26). Structure-activity studies identified dihdyromotuporamine C (dhMotC) as a potent and easily synthesized analogue. In this work, the mechanism of activity of dhMotC and STP-26 was investigated. It was fou

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23

Xia, Chang. "The role of reactive oxygen species and PI3K/AKT signaling in tumor angiogenesis." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4714.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains xi, 261 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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24

Walker, C. D. "Action of inositol 1,3,4,5 tetrakisphosphate on Ca 2+ movements in L1210 cells." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368190.

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25

Burniat, Agnès. "Etude de la tumorigenèse thyroïdienne et des effets anti-prolifératifs de la vitamine D active dans plusieurs modèles murins." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209664.

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Le but de la première partie de ce travail était de mieux comprendre la tumorigenèse thyroïdienne à<p>partir de modèles murins transgéniques développant des tumeurs de la thyroïde. Nous avons ainsi<p>analysé par microarrays l’expression génique au sein de thyroïdes de souris Tg-RP3 exprimant le<p>réarrangement RET/PTC3, responsable de cancers papillaires de la thyroïde chez l’homme (PTC), et<p>de souris Tg-E7 exprimant l’oncogène E7, responsable de cancers du col de l’utérus chez la femme.<p>Ces deux gènes étaient exprimés exclusivement dans la thyroïde grâce à un promoteur thyroglobuline.<p>N

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26

Pullyblank, Anne Maria. "Evaluation of the role of monoclonal antibodies m17-1A, c17-1A and cSF25 in antibody-dependent cell-mediated cytotoxicity and an exploration of the possible mechanisms of action." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268015.

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27

Rodrigues, Laura. "Nanoparticules polymères ciblant le récepteur CXCR3 : élaboration et évaluation sur modèles de tumeur." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0104/document.

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La thèse présentée porte sur l’élaboration de nanoparticules polymères fonctionnalisées par le ligand SCH546738 afin de cibler le récepteur CXCR3 surexprimé sur les cellules cancéreuses. La synthèse des copolymères à blocs Poly(triméthylène carbonate)-b-Poly(éthylène glycol) (PTMCb- PEG) et PTMC-b-PEG-SCH546738, puis leurs auto-assemblages dans l’eau avec des pourcentages différents de l’un par rapport à l’autre et enfin l’activité biologique de ces nanoparticules in vitro ont été réalisés. Une série de PTMC-b-PEG de fraction hydrophile massique f différentes (entre 34 et 6%) ont été obtenus p

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28

Behrang, Yasmin [Verfasser]. "Etablierung und Charakterisierung eines neuen humanen, hochdifferenzierten und funktionell-aktiven Tumormodells eines pankreatischen neuroendokrinen Tumors : Establishment and Characterization of a Novel Well-differentiated and Functionally Active Human Pancreatic Neuroendocrine Tumor Model / Yasmin Behrang." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1221084143/34.

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29

Catrina, Anca Irinel. "Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-102-4/.

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30

Turner, Penelope A. "Biologically active kigamicin analogues by sequential palladium catalysed C-O and C-C bond construction." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56392/.

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This thesis describes the study of the synthesis and biological evaluation of analogues of the kigamicin natural products. Chapter One gives a background to pancreatic cancer and explains the anti-austerity strategy for new therapeutics. It then describes the kigamicins and their biological activity, focusing on why they are thought to be clinically applicable. Other structurally related, tetrahydroxanthone containing, natural products are also discussed. Chapter Two focuses on the synthesis of the tetrahydroxanthone nucleus. Existing methodology is initially utilised, before exploring formati

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31

Gonczy, Blanka. "Design, synthesis and biological evaluation of nucleotide pro-drugs centred on clinically active anticancer nucleosides." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/99376/.

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Cancer is one the on the leading causes of mortality in world, causing 8.2 million deaths in 2012. In light of these statistics, the battle against cancer is ongoing. Nucleoside analogues are a major force in cancer chemotherapy. However, one problem accompanying nucleoside-based therapy is drug resistance, due to the abrogation of mechanisms that are crucial to their transformation to their bioactive metabolites (nucleoside phosphates). The ProTide technology was designed to overcome the limitations associated with nucleoside analogues. The technology enables the delivery of the nucleoside mo

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32

Cancel, Jean-Charles. "Etude des mécanismes moléculaires conférant aux cellules dendritiques XCR1+ leurs capacités à activer les lymphocytes cytotoxiques au cours d'une réponse antivirale et antitumorale." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0438.

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Les cellules dendritiques (DC) sont les sentinelles de l'organisme. Elles sont constituées de plusieurs sous-populations, chacune possédant des caractéristiques et fonctions propres. Les DC conventionnelles de type 1 (cDC1) sont l'une de ces sous-populations. Ces cellules sont identifiables dans tous les tissus, et quelle que soit l'espèce par l'expression d'un marqueur unique: le récepteur de chimiokine XCR1 (Crozat et al. 2010;2011). Les cDC1 possèdent des fonctions uniques qui promeuvent l'activation des lymphocytes, notamment via la présentation croisée d'antigènes exogènes (Cancel et al.

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33

Alshaer, Walhan. "Fonctionnalisation de liposomes par des aptamères pour le ciblage actif des cellules cancéreuses." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS055/document.

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Dans ce travail, nous avons pu sélectionner par la méthode SELEX un aptamère à ARN modifié, appelé Apt1, qui se lie avec une haute affinité au récepteur CD44. L'aptamère sélectionné a été modifié avec par des 2'-F-pyrimidines afin d’augmenter sa stabilité vis-à-vis des nucléases pour une application thérapeutique. Cet aptamère a été ensuite greffé sur des liposomes contenant des séquences de siRNA dirigées contre un gène rapporteur, dans le but d’un ciblage actif des cellules tumorales exprimant le récepteur CD44. Cette fonctionnalisation a été réalisée par la conjugaison d’un dérivé 3'-thiol

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34

Ablin, Richard, Howard Kynaston, Malcolm Mason, and Wen Jiang. "Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer." BioMed Central, 2011. http://hdl.handle.net/10150/610197.

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BACKGROUND:Transglutamiase-4 (TGase-4), also known as prostate transglutaminase, belongs to the TGase family and is uniquely expressed in the prostate gland. The functions of this interesting protein are not clearly defined. In the present study, we have investigated an unexpected link between TGase-4 and the melanoma differentiation-associated gene-7/interleukin-24 (MDA-7/IL-24), a cytokine known to regulate the growth and apoptosis of certain cancer and immune cells.METHODS:Frozen sections of normal and malignant human prostate tissues and human prostate cancer (PCa) cell lines PC-3 and CA-H

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35

Estornes, Yann. "Propriétés invasives de cellules tumorales coliques humaines : rôle de la famille ADF / cofiline, proteines régulatrices du cytosquelette d'actine." Lyon 1, 2007. http://www.theses.fr/2007LYO10132.

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36

Evans, Ashley L. "ID4 as a tumor suppressor: mechanism of action of ID4 in prostate cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2013. http://digitalcommons.auctr.edu/dissertations/743.

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Id proteins are members of basic helix-loop-helix family. However, Id proteins lack the basic binding domain, which prevents DNA binding, and thereby regulates transcription. There are four members in the Id protein family termed Idl-4. In prostate cancer the expression of Idl and Id3 is high, whereas member Id4 expression is low. Decreased expression of Id4 is due to promoter hypermethylation in prostate cancer as well as many other cancers. This observation led us to hypothesize that Id4 acts as a tumor suppressor in prostate cancer. Furthermore, evidence suggests ectopic Id4 expression in m

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37

Alba, Castellón Lorena 1984. "Snail1 expression in mesenchimal cells promotes tumorigenesis and tumor progression." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/403887.

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Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that the function of Snail1 in fibroblasts and mesenchymal stem cells (MSCs) also contributes to tumor progression. In tumors with a mesenchymal origin, expression of Snail1 in oncogenic MSCs is needed to maintain their tumorigenic capacity and is required in vivo for tumor formation. Therefore, its deletion results in the absence of tumors. In tumors with an epithelial origin, we demonstrated that S

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38

Collins, Laura. "The Mechanism of Action of a New Class of Nucleoside Analogs Targeting Gastrointestinal Tumours." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38845.

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Gastrointestinal malignancies such as liver and pancreatic cancers are the deadliest due to late detection and drug resistance. Nucleoside analogues, like Gemcitabine, are the conventional therapy despite their little impact on survival and off-target toxicity. A novel class of nucleoside analogues able to evade drug resistance mechanisms has been developed by the Guindon group and biologically screened in our lab. Some of these proprietary molecules were further equipped with a lipoate moiety designed to target cancer cell metabolism. LCB2151 and LCB2179 have emerged as the lead molecules in

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39

Giacalone, Pierre Ludovic. "Action de l'adrénomédulline dans le cancer épithélial de l'ovaire : relation avec les estrogènes et leurs récepteurs." Montpellier 1, 2003. http://www.theses.fr/2003MON1T004.

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Le cancer epithelial de l'ovaire est un cancer grave de la femme menopausee. Le traitement actuel associant de facon ideale une chirurgie la plus radicale et une chimiotherapie adjuvante ne permet une remission de courte duree dans les formes avancees. L'adrenomedulline est un peptide multifonctionnel dont les effets sur la carcinogenese se retrouvent a plusieurs niveaux : la proliferation tumorale, la stimulation de l'angiogenese et de la motilite cellulaire et l'inhibition de l'apoptose cellulaire. Enfin, les estrogenes, laisses de cote dans le cancer ovarien, voient leurs roles reevalues a

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Taieb, David. "Fonction antitumorale d'ARGBP2 dans le cancer du pancreas par inhibition de l'adhésion et de la migration cellulaire." Aix-Marseille 2, 2009. http://theses.univ-amu.fr.lama.univ-amu.fr/2009AIX22027.pdf.

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Le mauvais pronostic du cancer du pancréas est dû à son extension locorégionale rapide, à la rapidité d’apparition des métastases à distance et à la faible efficacité des chimiothérapies actuelles. A ce jour, l’identification d’oncogènes ou de gènes suppresseurs impliqués dans la maladie n’a pas permis d’aboutir à des traitements efficaces. Nous avons montré qu’ArgBP2 (Arg-binding protein 2) module les évènements cellulaires impliqués dans l’invasivité de ce cancer. ArgBP2 est une protéine multiadaptatrice impliquée dans la régulation du cytosquelette d’actine. ArgBP2 contrôle l’adhérence et l

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41

Watts, Sam. "The assessment and management of anxiety and depression in prostate cancer patients being managed with active surveillance." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/374751/.

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42

CHOKRI, MOHAMED. "Controle de l'activation du macrophage murin in-vitro et in-vivo : effet antitumoral et action de differents immunostimulants." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR13061.

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Mise au point d'une methode pour la proliferation de macrophages murins residents en presence de cellules nourricieres. Etablissement et caracterisation de differentes lignees cellulaires de macrophages. Utilisation de ces macrophages actives pour une immunotherapie de tumeurs solides chez la souris, comparaison avec des immunomodulateurs comme les interferons et le facteur de necrose tumorale

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43

Adigun, Risikat Ajibola. "Insight into the Reactivity of Metastasis Inhibitor, Imidazolium trans-[tetrachloro (dimethyl sulfoxide)(imidazole)ruthenate(III)], with Biologically-active Thiols." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/378.

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Imidazolium trans-[tetrachloro (dimethyl sulfoxide)(imidazole)ruthenate(III)], NAMI-A, is an experimental metastasis inhibitor whose specific mechanism of activation and action remains to be elucidated. In the nucleophilic and reducing physiological environment; it is anticipated that the most relevant and available reductants upon introduction of NAMI-A as a therapeutic agent will be the biologically-relevant free thiols. The kinetics and mechanisms of interaction of NAMI-A with biologically-active thiols cysteamine, glutathione, cysteine and a popular chemoprotectant, 2-mercaptoethane sulfon

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44

Wang, Suwei. "Mechanisms of Cr(VI)-induced carcinogenesis the involvement of reactive oxygen species and signal transduction pathway /." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1803.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains viii, 124 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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Menezes, Michelle dos Santos. "O papel do jaspamídeo na dinâmica do citoesqueleto de actina das células de melanoma: relação com migração e invasão." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-19032012-145318/.

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No processo de metástase os movimentos de migração e invasão tem um papel essencial e em ambos a função dos microfilamentos é de grande importância. Neste contexto, o presente trabalho buscoui analisar os efeitos da droga jaspamídeo e após a determinação das concentrações de IC50 para as linhagens HT144 e NGM foram estudados os efeitos da droga. Os tratamentos mostraram que o fármaco atua desorganizando o citoesqueleto de modo dependente de sua concentração. Os ensaios de ferida mostraram diminuição da taxa de fechamento da área livre após os tratamentos e os ensaios de migração com placas de

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Leite, IsmÃnia OsÃrio. "Estudo de fase I da vacina anticÃncer HASUMI." Universidade Federal do CearÃ, 2004. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=22.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>The Hasumi vaccine (VH) is an imune-stimulant mode by two preparations obtained from distinctive forms, it is an assisting in a pool of tumours antigens. The assisting is taken off from calf splens and the antigen, from different forms of tumor. The VH is a sterile uncoloured liquid, conditioned in 0,5mL glass ampoules, separately. The present research aimed to evaluate, throughout a Phase I study, the security of VH, as well as the comprehension of its action mechanism. The clinical experiment was conducted in 24 health

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LEBEAU, JEROME. "Alterations genetiques dans les tumeurs du sein : recherche d'oncogenes actives et de genes a expression deregulee." Paris 6, 1990. http://www.theses.fr/1990PA066577.

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Le travail presente dans cette these comporte trois chapitres distincts: 1. L'etude de l'amplification du gene du recepteur de l'egf dans une lignee cellulaire humaine de carcinome du sein, la lignee bt20. 2. Le clonage moleculaire de 25kbp en amont de l'exon 0 de l'oncogene humain k-ras provenant d'une lignee cellulaire tumorale mammaire, la lignee h-466b. 3. La mise en evidence de la surexpression constitutive d'une proteine de choc thermique: la hsp89alpha apres transformation de la lignee cellulaire mammaire hbl100 par un oncogene h-ras active

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GIRAULT, VERONIQUE. "Action de la chloroquine sur la secretion du tumor necrosis factor alpha et la survie dans le choc septique de la souris." Lyon 1, 1994. http://www.theses.fr/1994LYO1M126.

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Svangård, Erika. "Cytotoxic Cyclotides : Structure, Activity, and Mode of Action." Doctoral thesis, Uppsala universitet, Institutionen för läkemedelskemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6028.

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Cyclotides are small cyclic plant proteins, and this thesis addresses their cytotoxic structure-activity properties and their mode of action on human cancer cell lines. Cyclotides were isolated from Viola odorata and Viola tricolor; three novel cyclotide sequences and two known sequences, but of new origin, were identified using mass spectrometry, amino acid analysis, and Edman degradation. The cyclotide structure includes three disulphide bonds in a knotted arrangement, which forces hydrophobic amino acid residues to be exposed on the surface of the molecule; 3-D homology models of cyclotides

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Agarwal, Abhiruchi. "Nanocarrier mediated therapies for the gliomas of the brain." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39468.

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Existing methods of treating glioma are not effective for eradicating the disease. Therefore, new and innovative methods of treatment alone or in combination with existing therapies are necessary. Delivery of therapeutic agents through delivery carriers such as liposomes diminishes the harmful effects of the agent in healthy tissues and allows increased accumulation in the tumor. In addition, targeted chemotherapy using liposomes provides the opportunity for further increase in drug accumulation in tumor. However, the current targeting strategies suffer accelerated plasma clearance and are not

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