Relevant bibliographies by topics / Tunicamycin antibiotic

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Tunicamycin antibiotic'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "Tunicamycin antibiotic"

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Cockrum, PA, CCJ Culvenor, JA Edgar, MV Jago, AL Payne, and CA Bourke. "Toxic tunicaminyluracil antibiotics identified in water-damaged wheat responsible for the death of pigs." Australian Journal of Agricultural Research 39, no. 2 (1988): 245. http://dx.doi.org/10.1071/ar9880245.

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A unique mixture of toxic tunicaininyluracil antibiotics, closely related to the corynetoxins which causc annual ryegrass toxicity and to the tunicamycins, has been identified in rain-damaged, stored wheat implicated in a fatal intoxication of pigs. The toxins, present at a level of approximately 4.5 mg per kg, were isolated by preparative t.1.c. They displayed specific inhibition of uridine diphospho-N-acetylglucosamine : dolichol-phosphate N-acetylglucosamine-1-phosphate transferase and bacterial inhibition consistent with this type of antibiotic, and produced symptoms in rats identical with
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Buckley, Barbara J., and A. R. Whorton. "Tunicamycin increases intracellular calcium levels in bovine aortic endothelial cells." American Journal of Physiology-Cell Physiology 273, no. 4 (1997): C1298—C1305. http://dx.doi.org/10.1152/ajpcell.1997.273.4.c1298.

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Tunicamycin is a nucleoside antibiotic that inhibits protein glycosylation and palmitoylation. The therapeutic use of tunicamycin is limited in animals because of its toxic effects, particularly in cerebral vasculature. Tunicamycin decreases palmitoylation of the endothelial isoform of nitric oxide synthase, stimulates nitric oxide synthesis, and increases the concentration of intracellular calcium ([Ca2+]i) in bovine aortic endothelial cells (B. J. Buckley and A. R. Whorton. FASEB J. 11: A110, 1997). In the present study, we investigated the mechanism by which tunicamycin alters [Ca2+]iusing
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Patterson, SI, and JH Skene. "Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension." Journal of Cell Biology 124, no. 4 (1994): 521–36. http://dx.doi.org/10.1083/jcb.124.4.521.

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In neuronal growth cones, the advancing tips of elongating axons and dendrites, specific protein substrates appear to undergo cycles of posttranslational modification by covalent attachment and removal of long-chain fatty acids. We show here that ongoing fatty acylation can be inhibited selectively by long-chain homologues of the antibiotic tunicamycin, a known inhibitor of N-linked glycosylation. Tunicamycin directly inhibits transfer of palmitate to protein in a cell-free system, indicating that tunicamycin inhibition of protein palmitoylation reflects an action of the drug separate from its
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Hakulinen, Jonna K., Jenny Hering, Gisela Brändén, et al. "MraY–antibiotic complex reveals details of tunicamycin mode of action." Nature Chemical Biology 13, no. 3 (2017): 265–67. http://dx.doi.org/10.1038/nchembio.2270.

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Larskaya, Irina A., Farit A. Abdrahimov, and Evgenia O. Fedina. "The involvement of protein N-glycosylation in growth processes of Linum usitatissimum L." Butlerov Communications 64, no. 11 (2020): 121–26. http://dx.doi.org/10.37952/roi-jbc-01/20-64-11-121.

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The effect of tunicamycin, the inhibitor of protein N-glycosylation, on the root and hypocotyl growth of flax seedlings (Linum usitatissimum L.) was studied. It is known that tunicamycin inhibits the first stage of the formation of the oligosaccharide precursor, which is necessary to initiate the synthesis of N-glycoproteins by inhibiting the activity of N-acetylglucosamine phosphotransferase. The blocking by tunicamycin (25 μM) the early stages of N-glycoprotein formation induced growth inhibition in flax seedlings depending on the age of the plants. So one-day-old seedlings, tunicamycin sign
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Tyborowska, Jolanta, Ewa Zdunek, and Bogusław Szewczyk. "Effect of N-glycosylation inhibition on the synthesis and processing of classical swine fever virus glycoproteins." Acta Biochimica Polonica 54, no. 4 (2007): 813–19. http://dx.doi.org/10.18388/abp.2007_3172.

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Classical swine fever virus (CSFV) is often used as a surrogate model in molecular studies of the closely related hepatitis C virus. In this report we have examined the effect of the inhibition of glycosylation on the survival and maturation of CSFV. Viral glycoproteins (E(rns), E1, E2) form biologically active complexes - homo- and heterodimers, which are indispensable for viral life cycle. Those complexes are highly N-glycosylated. We studied the influence of N-glycosylation on dimer formation using E(rns) and E2 glycoproteins produced in insect cells after infection with recombinant baculov
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Webster, E. H., S. R. Hilfer, R. L. Searls, and J. Kornilow. "Effect of tunicamycin on maturation of fetal mouse lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 265, no. 3 (1993): L250—L259. http://dx.doi.org/10.1152/ajplung.1993.265.3.l250.

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The mesodermal capsule of the fetal lung plays a role in differentiation of the respiratory region. It has been proposed for other epithelial organs that the mesodermal capsule influences development by modifying the basal lamina or the extended extracellular matrix. The effect could be on deposition or turnover of collagens, proteoglycans, and/or glycoproteins. This study tests the role of glycoproteins in differentiation of respiratory endings by inhibiting their synthesis with the antibiotic tunicamycin (TM). Lungs at 16 and 18 days gestation and 3 days after birth were cultured with TM and
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Jenks, B. G., A. G. H. Ederveen, J. H. M. Feyen, and A. P. van Overbeeke. "The functional significance of glycosylation of proopiomelanocortin in melanotrophs of the mouse pituitary gland." Journal of Endocrinology 107, no. 3 (1985): 365–74. http://dx.doi.org/10.1677/joe.0.1070365.

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ABSTRACT Pro-opiomelanocortin (POMC) is a glycoprotein precursor for a number of neuropeptides and peptide hormones. The functional significance of the glycosylation of POMC has never been established. Using the antibiotic tunicamycin to block glycosylation of the prohormone in the mouse pars intermedia, we have compared processing of non-glycosylated prohormone with that of glycosylated prohormone in pulse-chase experiments. The peptides produced from non-glycosylated prohormone were shown to be correct cleavage products. Therefore it was concluded that, with the possible exception of peptide
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Rizzoli, R., and J. P. Bonjour. "Effects of lectins and tunicamycin on cAMP response to parathyroid hormone." American Journal of Physiology-Endocrinology and Metabolism 256, no. 1 (1989): E80—E86. http://dx.doi.org/10.1152/ajpendo.1989.256.1.e80.

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Carbohydrate moieties of cell surface glycoproteins with an external orientation play a role in hormone recognition and/or transmembrane signal transmission. We have examined the effect of various lectins, which interact with specific cell surface glycosyl residues, and of tunicamycin, an antibiotic that inhibits glycosylation of proteins, on the adenosine 3',5'-cyclic monophosphate (cAMP) response to parathyroid hormone (PTH) in confluent cultured osteoblast-like rat osteosarcoma cells (UMR-106) and opossum kidney cells (OK cells). Incubation of both cell lines with wheat germ lectin (WGL), b
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Hashim, Onn Haji, and William Cushley. "Minor modifications to the structure of tunicamycin lead to loss of the biological activity of the antibiotic." Biochimica et Biophysica Acta (BBA) - General Subjects 923, no. 3 (1987): 362–70. http://dx.doi.org/10.1016/0304-4165(87)90044-4.

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Dissertations / Theses on the topic "Tunicamycin antibiotic"

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Wang, Hua. "Semi-synthesis and biological evaluations of tunicamycin lipid analogues and investigation of the tunicamycin biosynthetic pathway." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:05c43287-9f84-45f4-8db4-0fb6c2763816.

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Tunicamycins are potent antimicrobial agents but are also toxic to mammalian cells, which render them clinically impractical to use to treat infectious diseases. Instead, they have been used extensively as biochemical tools to study the N-linked glycosylation of proteins. However, despite such a routine application, their inhibitory mechanisms are still not clear. The central objective of this thesis was to develop novel tunicamycin analogues that are non-toxic to eukaryotic cells that could serve as potential antimicrobial drug candidates. We hypothesised that if we retain the lipid character
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Wyszynski, Filip Jan. "Dissecting tunicamycin biosynthesis : a potent carbohydrate processing enzyme inhibitor." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:3a7a509d-dba0-4d5b-9a39-a883c872d758.

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Tunicamycin nucleoside antibiotics were the first known to target the formation of peptidoglycan precursor lipid I in bacterial cell wall biosynthesis. They have also been used extensively as inhibitors of protein N-glycosylation in eukaryotes, blocking the biogenesis of early intermediate dolichyl-pyrophosphoryl-N-acetylglucosamine. Despite their unusual structures and useful biological properties, little is known about their biosynthesis. Elucidating the metabolic pathway of tunicamycins and gaining an understanding of the enzymes involved in key bond forming processes would not only be of g
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Melotto-Passarin, Danila Montewka. "Transformação genética de cana-de-açúcar por biolística e Agrobacterium tumefaciens visando estudar o mecanismo de morte celular programada." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/11/11144/tde-14042009-082016/.

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A cana-de-açúcar é uma das principais culturas agrícolas plantadas no Brasil e apresenta significativa importância sócio-econômica e agroindustrial ao país. O cenário mundial encontrase bastante favorável no que concerne à comercialização de seus dois principais produtos derivados, o açúcar e o álcool, impulsionando o desenvolvimento do setor sucroalcooleiro nacional. Neste sentido, o melhoramento genético da cana-de-açúcar aparece como base fundamental para o desenvolvimento de novas variedades para a manutenção e incremento dos agronegócios da agroindústria sucroalcooleira. Técnicas de engen
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Isaacs, Rabia. "The in vitro effects of nicotine and selected antibiotics, tunicamycin and thapsigargin on human Breast carcinoma (mcf-7) cells." University of the Western Cape, 2012. http://hdl.handle.net/11394/4579.

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>Magister Scientiae - MSc<br>Cancer is defined as the abnormal growth of genetically mutated or perturbant cells. Nicotine is a known cancer promoter and an apoptotic suppressor. This alkaloid acts on the nicotinic acetylcholine receptors which affects the ubiquitin-proteasome protein degradation pathway and ultimately hinders apoptosis. The endoplasmic reticulum (ER) is an interconnecting organelle which synthesises proteins and its quality control processes ensures the proper protein folding, post-translational modifications and conformation of secretory and trans-membrane proteins. Studies
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Book chapters on the topic "Tunicamycin antibiotic"

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Beuth, J., H. L. Ko, R. Pfeiffer, A. Yassin, Y. Ohshima, and G. Pulverer. "Interference of Tunicamycin-Induced Staphylococcal Lectin Dysfunction with Specific Adherence Mechanisms and Immune Responses." In The Influence of Antibiotics on the Host-Parasite Relationship III. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73653-7_5.

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Conference papers on the topic "Tunicamycin antibiotic"

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NAKAMURA, Shin. "MONOCYTE/MACROPHAGE TISSUE FACTOR: ROLE OF ITS N-GLYCOSYLATED CARBOHYDRATE MOIETY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643286.

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Monocytes/macrophages and related cells are known to generate tissue factor (TF) , a membrane associated lipid-glycoprotein complex, following activation with LPS or other stimuli. Monkey (M. fuscata) mononuclear leukocytes (MNL, 3 × 106/ml) cultured with LPS (lµg/ml) in FCS-free RPMI medium were stimulated to produce the glycoprotein (TF-Apo). After a lag period of 2 h the TF-Apo production was initiated, and its accumulation reached the plateau after 12 h and then declined to approximately half of the maximum level after 24 h. A time course of the TF activity was strictly in accord with that
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