Relevant bibliographies by topics / TXA2

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'TXA2'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'TXA2.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "TXA2"

1

Chueh, Tsung-Hung, Yu-Hsiuan Cheng, Kuo-Hsin Chen, and Chiang-Ting Chien. "Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis." Thrombosis and Haemostasis 120, no. 02 (2019): 329–43. http://dx.doi.org/10.1055/s-0039-3400304.

Full text
Abstract:
Abstract Aim Enhancement of thromboxane A2 (TXA2) synthase (TXAS) activity, TXA2 release, and thromboxane prostanoid (TP) receptor activation leads to vasoconstriction and oxidative injury. We explored whether genetic deletion of TXAS/TXA2/TP signalling may reduce renal ischaemia/reperfusion (I/R) injury in mice. Materials and Methods Renal haemodynamics and function were evaluated in TXAS+/+TP+/+ (wild-type, WT), TXAS−/− (TXS−/−), TP−/− and TXAS−/−TP−/− (double knockout, dKO) mice in response to intravenous TXA2 mimetic-U46619 and 45-minute renal ischaemia and 4-hour reperfusion injury. We ex
APA, Harvard, Vancouver, ISO, and other styles
2

Chiang, Chih-Yao, Chen-Yen Chien, Wei-Yin Qiou, et al. "Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury." Thrombosis and Haemostasis 118, no. 11 (2018): 1982–96. http://dx.doi.org/10.1055/s-0038-1672206.

Full text
Abstract:
Objective Activation of thromboxane A2 synthase (TXAS)/thromboxane A2 (TXA2)/thromboxane prostanoid (TP) receptor leads to arterial constriction, platelet aggregation and vascular injury. We attempted to characterize the microvascular dysfunction in ischaemia/reperfusion injury using genetically modified TXAS−/−, TP−/− and TXAS−/−TP−/− mice. Approach and Results The cardiac micro-circulation and electrocardiograms were evaluated from B6, TXAS−/−, TP−/− and TXAS−/−TP−/− mice in response to intravenous saline, endothelin-1, U46619 (a TXA2 agonist) and myocardial ischaemia/reperfusion injury. Car
APA, Harvard, Vancouver, ISO, and other styles
3

Hadiyanti, Nur, Didik Hasmono, and Mohammad Saiful Islam. "Analysis of Differences of Serum Thromboxane B2 Level after Taking Acetosal in Acute Thrombotic Stroke with Diabetes Mellitus and Non-Diabetes Mellitus." Folia Medica Indonesiana 54, no. 1 (2018): 53. http://dx.doi.org/10.20473/fmi.v54i1.8053.

Full text
Abstract:
Endothelial dysfunction and vascular injuries are the early processes in thrombogenesis leading to thrombotic stroke. These processes trigger platelet activation characterized by synthesis of Thromboxane A2, potent agonist in platelet aggregation. Acetosal (ASA) 100 mg usually given to thrombotic stroke patients exerts its pharmacological effect by inhibition of TxA2 synthesis, thus could prevent thrombus formation. Diabetes mellitus (DM) as risk factor of thrombotic stroke exhibits an increase in TxA2 synthesis. It is not known whether ASA 100 mg could inhibit TxA2 adequately in diabetic pati
APA, Harvard, Vancouver, ISO, and other styles
4

Weber, C., J. R. Beetens, F. Tegtmeier, et al. "Ridogrel Inhibits Systemic and Renal Formation of Thromboxane A2 and Antagonizes Platelet Thromboxane A2/Prostaglandin Endoperoxide Receptors upon Chronic Administration to Man." Thrombosis and Haemostasis 68, no. 02 (1992): 214–20. http://dx.doi.org/10.1055/s-0038-1656351.

Full text
Abstract:
SummaryThe effects of ridogrel, a dual thromboxane A2 (TXA2) synthase inhibitor and TXA2/prostaglandin (PG) endoperoxide receptor antagonist, on systemic and renal production of prostaglandins and on platelet TXA2/PG endoperoxide receptors was evaluated upon chronic administration (300 mg b. i. d. orally, for 8 and 29 days) to man. Such a medication with ridogrel inhibits the systemic as well as the renal production of TXA2 as measured by the urinary excretion of 2,3-dinor-TXB2 and TXB2 respectively without inducing significant changes in systemic or renal PGI2 production. Simultaneously with
APA, Harvard, Vancouver, ISO, and other styles
5

Cudd, T. A., and C. E. Wood. "Does thromboxane mediate the fetal ACTH response to acidemia?" American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 270, no. 3 (1996): R594—R598. http://dx.doi.org/10.1152/ajpregu.1996.270.3.r594.

Full text
Abstract:
Intravenous mineral acid infusions into fetal sheep stimulate increases in plasma adrenocorticotropic hormone (ACTH) and cortisol concentrations that correlate to the induced changes in arterial pH (pHa). We have recently demonstrated that ACTH and cortisol responses to mineral acid infusion in adult sheep are mediated by thromboxane A2 (TxA2). We designed the present experiments to test the hypothesis that fetal ACTH and cortisol responses are also mediated by TxA2. We infused chronically instrumented fetal sheep with 1 N HCl (0.5 ml/min i.v.) for 60 min, with or without pretreatment with the
APA, Harvard, Vancouver, ISO, and other styles
6

Cong, Ping, Zuo-Liang Xiao, Piero Biancani, and Jose Behar. "Prostaglandins mediate tonic contraction of the guinea pig and human gallbladder." American Journal of Physiology-Gastrointestinal and Liver Physiology 292, no. 1 (2007): G409—G418. http://dx.doi.org/10.1152/ajpgi.00091.2006.

Full text
Abstract:
The gallbladder (GB) maintains tonic contraction modulated by neurohormonal inputs but generated by myogenic mechanisms. The aim of these studies was to examine the role of prostaglandins in the genesis of GB myogenic tension. Muscle strips and cells were treated with prostaglandin agonists, antagonists, cyclooxygenase (COX) inhibitors, and small interference RNA (siRNA). The results show that PGE2, thromboxane A2 (TxA2), and PGF2α cause a dose-dependent contraction of muscle strips and cells. However, only TxA2 and PGE2 (E prostanoid 1 receptor type) antagonists induced a dose-dependent decre
APA, Harvard, Vancouver, ISO, and other styles
7

Giubilato, Simona, Andrea Leo, Nicola Cosentino, et al. "Predictors of thromboxane levels in patients with non-ST-elevation acute coronary syndromes on chronic aspirin therapy." Thrombosis and Haemostasis 108, no. 07 (2012): 133–39. http://dx.doi.org/10.1160/th11-09-0635.

Full text
Abstract:
SummaryHigh levels of thromboxane A2 (TxA2), a key mediator of platelet activation and aggregation, are associated with an increased risk of cardiovascular events. We aimed at assessing the predictors of higher plasma levels of TxB2, the stable metabolite of TxA2, in consecutive patients presenting with non-ST-elevation acute coronary syndrome (NSTE-ACS) on previous aspirin (ASA) treatment undergoing coronary angiography. Ninety-eight consecutive patients (age 61 ± 11, 75% males) with NSTE-ACS, on previous chronic ASA treatment, were prospectively enrolled in this study. Coronary disease exten
APA, Harvard, Vancouver, ISO, and other styles
8

Yokoyama, Yukihiro, Hongzhi Xu, Nicole Kresge, et al. "Role of thromboxane A2 in early BDL-induced portal hypertension." American Journal of Physiology-Gastrointestinal and Liver Physiology 284, no. 3 (2003): G453—G460. http://dx.doi.org/10.1152/ajpgi.00315.2002.

Full text
Abstract:
Although the mechanisms of cirrhosis-induced portal hypertension have been studied extensively, the role of thromboxane A2 (TXA2) in the development of portal hypertension has never been explicitly explored. In the present study, we sought to determine the role of TXA2 in bile duct ligation (BDL)-induced portal hypertension in Sprague-Dawley rats. After 1 wk of BDL or sham operation, the liver was isolated and perfused with Krebs-Henseleit bicarbonate buffer at a constant flow rate. After 30 min of nonrecirculating perfusion, the buffer was recirculated in a total volume of 100 ml. The perfusa
APA, Harvard, Vancouver, ISO, and other styles
9

Xu, Hongzhi, Katarzyna Korneszczuk, Amel Karaa, Tian Lin, Mark G. Clemens, and Jian X. Zhang. "Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 288, no. 2 (2005): G277—G283. http://dx.doi.org/10.1152/ajpgi.00256.2004.

Full text
Abstract:
We examined the role of thromboxane A2 (TXA2) in LPS-induced hyperresponsiveness of hepatic portal circulation to endothelins (ETs) and whether Kupffer cells are the primary source of TXA2 release in response to ET-1 in endotoxemia. After 6 h of LPS (1 mg/kg body wt ip) or saline (control), liver was isolated and perfused with recirculating Krebs-Henseleit bicarbonate buffer at a constant flow rate (100 ml·min−1·kg body wt−1). ET-1 (10 pmol/min) was infused for 10 min. Portal pressure (PP) was continuously monitored during perfusion. Perfusate was sampled for enzyme immunoassay of thromboxane
APA, Harvard, Vancouver, ISO, and other styles
10

Grone, H. J., R. S. Grippo, W. J. Arendshorst, and M. J. Dunn. "Role of thromboxane in control of arterial pressure and renal function in young spontaneously hypertensive rats." American Journal of Physiology-Renal Physiology 250, no. 3 (1986): F488—F496. http://dx.doi.org/10.1152/ajprenal.1986.250.3.f488.

Full text
Abstract:
As platelet and renal thromboxane (TX)A2 synthesis are increased in spontaneously hypertensive rats (SHR), we tested the hypothesis that increased renal TXA2 synthesis may cause the reduction in glomerular filtration rate (GFR), renal plasma flow (RPF), and the increase in arterial pressure in SHR of the Okamoto-Aoki strain. A selective inhibitor of TXA2 synthetase (UK 38485) was given acutely, with or without a TXA2 receptor antagonist (EP-092), to 6- to 8-wk-old SHR and age-matched Wistar-Kyoto rats (WKY) and chronically for 5.5 wk to 3.5-wk-old SHR. Inhibition of TXA2, measured by the stabl
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "TXA2"

1

Kaiser, Ralf Dieter. "Recherche sur l'influence des sympathomimétiques et des prostaglandines PGE2 et PGI2 sur l'équilibre PGI2/TXA2 du coeur." Toulouse 3, 1990. http://www.theses.fr/1990TOU30166.

Full text
Abstract:
Les recherches de l'auteur ont porte d'une part sur le role joue par des sympathomimetiques directs et indirects ainsi qu'un inhibiteur de la recaptation du neurotransmetteur sur l'equilibre txa2/pgi2 implique dans l'homeostasie cardiovasculaire et plaquettaire d'autre part, sur l'effet de la pgi2 et de la pge2 deux eicosanoides etant impliques dans l'homeostasie cardiovasculaire. Chaque produit a ete teste in vitro et ex vivo sur le cur isole de lapin. Les experiences realisees dans les conditions adoptees ont montre que: 1) les sympathomimetiques directs et indirects ainsi que la desipramine
APA, Harvard, Vancouver, ISO, and other styles
2

Dahou, Rihab. "Exploration de la rupture des plaques d'athérosclérose et du devenir des plaquettes agrégées in vivo par mircroscopie électronique à balayage." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ115.

Full text
Abstract:
La thrombose est souvent liée à la survenue d’une rupture de la plaque d’athérosclérose qui expose le tissu sous endothélial thrombogène aux plaquettes sanguines circulantes. L’un des problèmes actuels est l’identification des mécanismes qui sont à l’origine de la fracture. Nous avons testé l’hypothèse que la vasoconstriction, induite par le LTC4 ou le thromboxane A2 (TXA2), joue un rôle dans la rupture de plaques d’athérosclérose et dans la formation de l’athérothrombose. Dans ce travail nous avons adapté la technique classique de la microscopie électronique pour observer les ruptures survenu
APA, Harvard, Vancouver, ISO, and other styles
3

Michel, Fréderic. "Système Rénine Angiostensine Aldostérone et néovascularisation post-ischémique." Paris 7, 2005. http://www.theses.fr/2005PA077040.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Palhares, de Miranda Ana Luisa. "Recherches sur les effecteurs de la biosynthèse de la prostacycline (PGI2), de la thromboxane A2 (TXA2) et du facteur anti-thromboxane synthétase ("FATS")." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb376002796.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Araujo, Luciane Cruz Lopes. "Estudo comparativo dos efeitos do nimesulide e do AAS sobre : a agregação plaquetaria, tempo de sangramento e produção de TXA2 em voluntarios sadios." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290185.

Full text
Abstract:
Orientador: Thales Rocha de Mattos Filho<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-07-22T12:23:22Z (GMT). No. of bitstreams: 1 Araujo_LucianeCruzLopes_D.pdf: 5490102 bytes, checksum: 5caae8500670ea147adcb8d9112d9e19 (MD5) Previous issue date: 1997<br>Resumo: O efeito terapêutico dos antiinflamatórios não esteroidais (NSAIDs) vem acompanhado de efeitos indesejáveis relacionados à irritação gástrica, alterações de hemostasia, entre outros. Nimesulide (NMSL) é um NSAID que apresenta mecanismo de ação basta
APA, Harvard, Vancouver, ISO, and other styles
6

Ravelli, Katherine Garcia. "Estudo do mecanismo de ereção peniana causada pela toxina TX2-6 produzida pela aranha Phoneutria nigriventer." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-14092011-172346/.

Full text
Abstract:
O veneno produzido pela aranha Phoneutria nigriventer causa priapismo. O pré-tratamento de camundongos com inibidores da Óxido nítrico-sintase, antes de se injetar a toxina, inibe este priapismo. A toxina causa ativação do gene c-fos no núcleo paraventricular do hipotálamo (NPV). Este estudo tem como objetivo ampliar os conhecimentos relacionados ao mecanismo da ereção peniana causada pela toxina Tx2-6. A toxina foi injetada no NPV e os resultados não mostraram o envolvimento direto do mesmo com o priapismo. Procuramos então avaliar se há aumento na produção de óxido nítrico (NO) quando o tec
APA, Harvard, Vancouver, ISO, and other styles
7

Matavel, Alessandra Cristine de Souza. "Tx2-6, uma toxina da aranha Phoneutria nigriventer que modifica os canais de Na+ sensíveis à voltagem." Universidade Federal de Minas Gerais, 1999. http://hdl.handle.net/1843/BUBD-9GAG4N.

Full text
Abstract:
Many organisms produce polypeptides with toxic activity against other organisms. The voltage-gated sodium channels are the main targets of many toxins studied so far. Two specific binding sites of polypeptide toxins have been particularly characterized on the sodium channels. Toxins which bind to the site 3 cause persistent activation of sodium channel by inhibiting the inactivation. Toxins which bind to the site 4 shift the voltage dependence of activation to more negative potentials. The toxin Tx2-6, obtained from PhTx2 fraction of the Brazilian Phoneutria nigriventer spider venom, is a basi
APA, Harvard, Vancouver, ISO, and other styles
8

Hamzeh, Basem [Verfasser], and JOHANNES [Akademischer Betreuer] WESTENDORF. "Die Wirkung von Morinda citrifolia L. (Noni) Fruchtsaft auf die Bildung der Entzündungsmediatoren PGE2, TXB2 und LTB4 / Basem Hamzeh. Betreuer: Johannes Westendorf." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1106404971/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Hamzeh, Basem [Verfasser], and Johannes [Akademischer Betreuer] Westendorf. "Die Wirkung von Morinda citrifolia L. (Noni) Fruchtsaft auf die Bildung der Entzündungsmediatoren PGE2, TXB2 und LTB4 / Basem Hamzeh. Betreuer: Johannes Westendorf." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-79646.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Johng, Breeana J. "A Mathematical Model of the Effect of Aspirin on Blood Clotting." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/718.

Full text
Abstract:
In this paper, we provide a mathematical model of the effect of aspirin on blood clotting. The model tracks the enzyme prostaglandin H synthase and an important blood clotting factor, thromboxane A2, in the form of thromboxane B2. Through model analysis, we determine conditions under which the reactions of prostaglandin H synthase are self-sustaining. Lastly, through numerical simulations, we demonstrate that the model accurately captures the steady-state chemical concentrations of interest in blood, both with and without aspirin treatment.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "TXA2"

1

Arnold, Lobel. Ming Lo moves the mountain =: Ming Lo txav lub pob tsuas. Greenwillow Books, 2000.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Alvarez-Mon, Macarena. Chat Familiar- Xat Familiar-The Family Chat-Familia Txat. Independently Published, 2020.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Historic Hotels of Texas: A Traveler's Guide (Txam Travel Guides). Texas A&M University Press, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "TXA2"

1

Wetzka, Birgit, Dawn E. Clark, D. Steve Charnock-Jones, Hans Peter Zahradnik, and Stephen K. Smith. "PGE2 and TXA2 Production by Isolated Macrophages from Human Placenta." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1810-9_88.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Schrör, Karsten, Karen Davis-Bruno, and Perry V. Halushka. "Modification on Ligand Binding to TXA2/PGH2 Receptors by Diethylpyrocarbonate." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5325-0_34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Honemann, Christian W., Bernard Lo, Jo S. Erera, Renate Polanowska-Grabowska, Adrean R. L. Gear, and Marcel Durieux. "Local Anesthetic Effects on TXA2 Receptor Mediated Platelet Aggregation Using Quenched Flow Aggregometry." In Advances in Experimental Medicine and Biology. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4793-8_40.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Theis, J. G. W., H. Dellweg, E. Perzborn, and R. Groß. "pH-Dependent Binding of the TXA2/PGH2-Receptor of Human Platelet Membranes to Various Ligands." In Prostaglandins in the Cardiovascular System. Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7262-1_31.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Beitz, J., A. Beitz, Ch Giessler, et al. "Influence of a Cholesterol Rich Diet in Rabbits on the Formation of PGI2 and TXA2." In Prostaglandins in the Cardiovascular System. Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7262-1_33.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Müller, G., A. Beitz, J. Beitz, and C. Giessler. "Von-Willebrand’s disease and hemophilia are associated with diminished TXA2 formation in clotting whole blood." In 25. Hämophilie-Symposion Hamburg 1994. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-79648-7_65.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Sugimoto, S., A. Terashi, Y. Katayama, et al. "Role of Prostaglandins in Experimental Ischemic Brain Edema in Hypertensive Rats: TXA2 Priority in Hypertensive Rats." In Brain Edema. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70696-7_58.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Karanian, J. W., and N. Salem. "Hydroxylated 22-Carbon Fatty Acids in Platelet and Vascular Smooth Muscle Function: Interference with TXA2/PGH2 Receptors." In Mediators in the Cardiovascular System: Regional Ischemia. Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7346-8_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Suzuki, Shigeharu, Hiroki Ohkuma, Takashi Iwabuchi, and Noriaki Yoshimura. "Cerebral Microthrombosis, Synthesis Imbalance of TXA2-PGI2, and Subarachnoid Focal Acidosis in the Pathogenesis of Symptomatic Cerebral Vasospasm." In Advances in Surgery for Cerebral Stroke. Springer Japan, 1988. http://dx.doi.org/10.1007/978-4-431-68314-8_75.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Kpodonu, Jacques. "Zenith TX2 Thoracic Endograft." In Manual of Thoracic Endoaortic Surgery. Springer London, 2010. http://dx.doi.org/10.1007/978-1-84996-296-4_18.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "TXA2"

1

Kyrle, P. A., H. G. Eichler, and K. Lechner. "PROSTACYCLIN AND THROMBOXANE A2 GENERATION IN VIVO IN MAN -EFFECT OF LOW DOSE ASPIRIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643371.

Full text
Abstract:
The effect of a low-dose aspirin regimen on platelet and vascular prostaglandin metabolism was studied in vivo in man. In a double-blind placebo-controlled cross-over study, 7 healthy male volunteers were treated with aspirin (35 mg.day−1 or placebo for 7 days. After a washout period of 2 weeks, the subject were crossed to the alternate treatment. 12 hours after the last dose of aspirin or placebo formation of thromboxane A2 (TxA2) and prostacyclin (FGI2) was measured in blood emerging from a standardized injury of the microvasculature made to determine bleeding time. TxA2 and PGI2 were measur
APA, Harvard, Vancouver, ISO, and other styles
2

Johnson, G. J., P. C. Dunlop, M. J. Rabiet, L. A. Leis, and AH L. From. "THE DIHYDROPYRIDINE CALCIUM CHANNEL AGONIST, BAY K 8644, AND THE ANTAGONIST, NIFEDIPINE, INHIBIT U46619-INDUCED HUMAN PLATELET ACTIVATION BY COMPETITIVE BINDING TO THE THROMBOXANE A22/PGH2 RECEPTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643756.

Full text
Abstract:
The dihydropyridine (DP) Ca2+ channel antagonist, nifedipine (NF), inhibits platelet aggregation .in vitro and ex vivo by an undefined mechanism. Inhibition of Ca2+ influx via Ca2+ channels is a postulated mechanism, but voltage-dependent Ca2+ channels have not been demonstrated in platelets. We previously observed that NF blocked thromboxane A2 (TXA2)-induced platelet aggregation and secretion. In order to further evaluate the mechanism of DP inhibition of platelet activation, we studied the effects of NF and BAY K 8644, (BAY), a DP with opposite (agonist) effects on muscle cells, on human pl
APA, Harvard, Vancouver, ISO, and other styles
3

De Clerck, F., R. Van de Wiele, B. Xhonneux, et al. "PLATELET TXA2 SYNTHETASE INHIBITION AND TXA2/PROSTAGLANDIN ENDOPEROXIDE RECEPTOR BLOCKADE COMBINED IN ONE MOLECULE (R 68070)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643465.

Full text
Abstract:
F 68070, an oxime-alkane carboxylic acid derivative (Janssen Pharmaceutica), is a potent inhibitor of thromboxane A2 (TXA2) synthetase activity (IC50 in vitro against thrombin-stimulated human platelets in plasma : R 68070 : 2.9 x 10-8 M; CGS 13080 : 6 x 10-8 M; OKY-1581 : 8.2 x 10-8 M; dazmegrel : 2.6 x 10-8 M; dazoxiben : 2.3 x 10-8 M).The compound specifically inhibits platelet TXA2 synthetase activity (14C-arachidonic acid metabolism by washed human platelets) without effect on the cyclo-oxygenase, lipoxygenase (platelets, RBL cells) or prostacyclin synthetase activities (rat aortic rings)
APA, Harvard, Vancouver, ISO, and other styles
4

Van de Water, A., R. Xhonneux, and F. De Clerck. "ANTI-THROMBOTIC EFFECT IN CANINE CORONARY ARTERIES OF A COMBINED TXA2 synthetase/TXA2-prostaglandin ENDOPEROXIDE RECEPTOR INHIBITOR (R 68070)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643463.

Full text
Abstract:
The effects of R 68070 an oxime-alkane carboxylic acid derivative combining specific thromboxane A2 (TXA2) synthetase inhibition with TXA2/prostaglandin endoperoxide receptor blockade in one molecule, on thrombus formation in a coronary artery following electrically-induced endothelial injury and on its myocardial repercussions were examined in dogs. In an open-chest model in anaesthetized dogs, a stainless steel electrode was inserted into the left anterior descending coronary artery (LAD) distally (+ 1 cm) from an electromagnetic flow probe. ECG and heart rate were derived from limb leads. S
APA, Harvard, Vancouver, ISO, and other styles
5

Swedenborg, J., C. Greén, J. Lewin, and O. Vesterquist. "INCREASED IN VIVO FORMATION OF THROMBOXANE AND PROSTACYCLIN IN HUMANS AFTER AORTIC REPLACEMENT WITH SYNTHETIC GRAFTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642839.

Full text
Abstract:
Replacement of arteries with synthetic grafts causes activation of both plasma coagulation and platelets. In order to measure platelet activation the in vivo production of thromboxane A2 (TxA2) and prostacyclin (PGI2) were measured in patients following graft replacement of the abdominal aorta for aneurysmal disease.Specific methods based on gas chromatography-mass spectrometry using tetra-deuterated internal standards/carriers were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto PGF1α, the two major urinary metabolites of TxA2 and PGI2. The excretion of the metabo
APA, Harvard, Vancouver, ISO, and other styles
6

Scharf, R. E., A. Wehmeier, and W. Schneider. "REDUCED PLATELET THROMBOXANE FORMATION IN ACUTE THROMBOTIC THROMBOCYTOPENIC PURPURA (TP): EVIDENCE FOR AN ABNORMAL PLATELET POPULATION WITH A TRANSIENT CYCLOOXYGENASE DEFECT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644588.

Full text
Abstract:
We have recently shown that alpha-granule-depleted platelets circulate in acute TTP. These platelets are hemostatically defective due to partial loss of granular constituents and/or metabolic abnormalities. To further evaluate morphometric and metabolic changes of "exhausted" platelets, we studied their volume distribution and thromboxane A2 (TXA2) formation in a 35-year-old patient with primary TTP. Platelet volume distribution in whole blood was determined by the impedance method using citrate (0.38%)/glutaraldehyde (0.125%) as anticoagulant. TXB2 production was measured radioimmunologically
APA, Harvard, Vancouver, ISO, and other styles
7

Kienast, J., J. Arnout, G. Pfliegler, H. Deckmyn, B. Hoet, and J. Vermylen. "DISSOCIATION OF PHOSPHOLIPASE A2 ACTIVATION FROM CYTOSOLIC FREE CA2+ MOBILIZATION IN PLATELETS EXPOSED TO FLUORIDE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644529.

Full text
Abstract:
Elevated cytosolic free Ca2+ concentrations ([Ca2+]i) are thought to be required for phosphol ipase A2 activity to liberate arachidonic acid (AA) from membrane phospholipids in platelets. The major AA metabolite formed during agonist-induced platelet activation is thromboxane A2 (TxA2). We have investigated the effect of sodium fluoride (NaF) on platelet TxAz formation in correlation to platelet functional changes (aggregation and release of ATP) and intracellular events specific for either agonist- or antagonist-induced platelet responses. A first peak in platelet TxAffi formation reaching 30
APA, Harvard, Vancouver, ISO, and other styles
8

Jageneau, A., W. Loots, A. Nevelsteen, and F. De Clerck. "PLATELET-MEDIATED REDUCTION OF PERIPHERAL TISSUE PERFUSION IN THE CAT : SEROTONIN AND PROSTANOIDS ARE CAUSAL VASOACTIVE MODULATORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644599.

Full text
Abstract:
In cats, a femoral artery was ligated in order to mobilize a collateral circulation in the hind leg, leaving the contralateral artery intact. Graded infusions of collagen (50 to 400 μg/kg) in the aorta above the bifurcation reduced the blood flow, mainly in the collateral circulation (&gt; 80 %). Plasma 5-HI and TXB2 increased in local arterial blood. Ketanserin or ritanserin (S2-receptor blockade, 0.63 mg/kg I.V.) and dazoxiben or R 68070 (TXA2 synthetase inhibition, 5 and 1.25 mg/kg I.V.) reduced (&gt; 50 %, p &lt; 0.05) the collagen-induced loss of tissue perfusion. Indomethacin (10 mg/kg I
APA, Harvard, Vancouver, ISO, and other styles
9

Stemeier, K., J. Mertin, J. Pill, and F. Hartig. "EFFECTS OF THROMBOXANE RECEPTOR BLOCKER BM 13.505 ON THE DEVELOPMENT OF PROTEINURIA IN AUTOIMMUNE NZB/W MICE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643757.

Full text
Abstract:
Female F1 hybrid of New Zealand black and white mice(NZB/W) spontaneouslydevelop an autoimmune disease characterize by afatal immune complex glomerulonephritis.Theyare considered to be a relevant model of human systemic lupus erythematosus. We observeda doubling of the concentration of TXB2 in urine at the same time when onset of proteinuria was noticed. This suggests that TXA2 synthetized by mesangial and epithelial cells of the glomeruli as well as by some inflammatory cells and platelets might be an important mediator in the pathogenesis of thi auto immune-mediated glomerular disease. Weuse
APA, Harvard, Vancouver, ISO, and other styles
10

Jian, Wang, Lu Yungcai, Zhen Erzhen, Guo Zhaozheng, and Shi Fang. "EFFECT OF LIPID PEROXIDES ON PROSTACYCLIN AND THROMBOXANE GENERATION IN HYPERCHOLESTEROLEMIC RABBITS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643375.

Full text
Abstract:
Rabbits feeding on atherogenic diet for 60 days resulted in high level of plasma lipid peroxides as well as extreme hypercholesterolemia. Both of them kept at high level until 35 days after atherogenic diet stopped. At the same time, as compared with the control group, plasma PGI2 level was remarkably decreased while TXA2 and platelet aggregability were increased. Atherosclerotic vessel walls contain high levels of lipid peroxides associated with decreased PGI2 and increased TXA2 generation. Atherosclerotic plaques had the highest level of lipid peroxides and TXA2 while PGI production was the
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "TXA2"

1

Pritchard, Howard Porter Jr. LANL Applications on ARM TX2 and ARMie - an update. Office of Scientific and Technical Information (OSTI), 2019. http://dx.doi.org/10.2172/1569717.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'TXA2' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography