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Journal articles on the topic 'Tymnos'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Oğuz Kırca, E. Deniz, Tolga Özhan, and Volkan Demirciler. "A New Hellenistic Contribution List from Tymnos in Karia. The Kaletepe Inscription." Gephyra 27 (April 1, 2024): 1–10. http://dx.doi.org/10.37095/gephyra.1435868.

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This article introduces a new fragmentary inscription discovered on the hillside during the archaeological survey at Kaletepe, situated northeast of Bozburun, in 2022. The inscription, which dates to the Hellenistic period, lists eight non-natives of Tymnos along with their hometowns and monetary contributions for the augmentation (epauxesis) of an unidentified purpose. Parallel examples suggest that they may have been affiliated with a cult or a professional association.

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Thomas, Windhöfel,. "Tymbos für Ernst-Wolfgang Böckenförde, Robert Spaemann, Hans-Bernhard Wuermeling." Zeitschrift für Lebensrecht 28, no. 1 (2019): 0. http://dx.doi.org/10.3790/zfl.28.1.edit.

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3

Bru, Hadrien, Guy Labarre, and Mehmet Özsait. "La constitution civique de Tymandos." Anatolia Antiqua 17, no. 1 (2009): 187–207. http://dx.doi.org/10.3406/anata.2009.1281.

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Rudolph, Holly R., and Joy V. Peluchette. "Significance Of Usefulness: A Congruency Model Of Relevant Research Criteria." Journal of Applied Business Research (JABR) 8, no. 3 (2011): 83. http://dx.doi.org/10.19030/jabr.v8i3.6148.

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In an effort to enhance the relationship between the practitioners research needs and the researchers response to these needs, this paper proposes a congruency model of relevant research criteria utilizing Thomas and Tymons (1982) five components of research relevance. The model poses a series of questions that can be raised by each party as research is conducted, thereby increasing the practical relevance of academic research. Discussion is also extended to how research relevance relates to the scientific research process.

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5

Saag, K. G., P. D. Miller, F. Cosman, et al. "Persistent Fracture Reduction with Abaloparatide-SC (TYMLOS™) Followed by 24 Months of Alendronate." Journal of Clinical Densitometry 21, no. 4 (2018): 606–7. http://dx.doi.org/10.1016/j.jocd.2018.05.028.

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6

Jie, Yanghua, Xiaobei Yang, and Weidong Chen. "Expression and gene regulation network of TYMS and BCL2L1 in colorectal cancer based on data mining." PeerJ 9 (June 2, 2021): e11368. http://dx.doi.org/10.7717/peerj.11368.

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Background The purpose of this study was to study the role of thymidylate synthetase (TYMS) and B-cell lymphoma-2 like 1 (BCL2L1) in the occurrence and development of colorectal cancer and its potential regulatory mechanism. Methods The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed to examine the expression and prognostic value of TYMS and BCL2L1 in colorectal cancer. C-BioPortal analysis was used to detect the TYMS and BCL2L1 alterations. Through The Human Protein Atlas (THPA), the TYMS and BCL2L1 protein levels were also assessed. The protein protein interaction

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7

Khushman, Moh’d, Girijesh Kumar Patel, Anu Singh Maharjan, et al. "The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens." Pharmacogenomics Journal 21, no. 3 (2021): 308–17. http://dx.doi.org/10.1038/s41397-021-00210-2.

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Abstract Introduction The prevalence of 2R/2R TYMS genotype is variable but estimated to be around 20–30% in Caucasians. The clinical relevance of TYMS 2R/2R genotype in predicting severe fluoropyrimidine-related adverse events (FrAE) is controversial. Here, we explored the prevalence and clinical relevance of 2R/2R TYMS genotype. Methods Between 2011 and 2018, 126 patients were genotyped for TYMS. FrAEs were graded according to CTCAE version 5.0. Fisher’s exact test was used for statistical analysis. Results The prevalence of TYMS 2R/2R genotype was 24.6%. Among patients with TYMS genotypes (

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8

Margolis, Bernard. "IN THE NEWS." Bottom Line 1, no. 4 (1988): 10–14. http://dx.doi.org/10.1108/eb025137.

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ALA Fights Proposed Access Charges. Library services could be seriously harmed by a new Federal Communications Commission (FCC) proposal to charge networks such as Telenet. Tymnet, CompuServe, and other “enhanced service providers” access charges to local phone lines.

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Aubets, Eva, Alex J. Félix, Miguel Garavís, et al. "Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins." International Journal of Molecular Sciences 21, no. 14 (2020): 5028. http://dx.doi.org/10.3390/ijms21145028.

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Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-quadruplexes (G4) can modulate gene expression, we searched for putative G4 forming sequences (G4FS) in the TYMS gene that could be targeted using polypurine reverse Hoogsteen hairpins (PPRH). G4 structures in the TYMS gene were detected using the quadruplex forming G-rich sequences mapper and confirmed through spectroscopic approaches such as circula

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10

Moser, Judy. "A Smartcom II Macro for Automatic Logon via TYMNET." OCLC Micro 2, no. 5 (1986): 28–30. http://dx.doi.org/10.1108/eb055802.

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11

Plage, Henning, Sebastian Hofbauer, Kira Furlano, et al. "Abstract 5131: TYMS overexpression - but not copy number alteration - is associated with cancer aggressiveness in urothelial bladder cancer." Cancer Research 84, no. 6_Supplement (2024): 5131. http://dx.doi.org/10.1158/1538-7445.am2024-5131.

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Abstract Background: Thymidylate Synthetase (TYMS) is an import enzyme in the early stage of DNA biosynthesis. It is coded by the TYMS gene at 18p11.32, a region which has been found amplified in urothelial carcinoma. TYMS is a target enzyme for 5-fluorouracil (5-FU) and methotrexate. Elevated TYMS expression has been associated with poor prognosis and unfavorable therapy response in different cancer types. The aim of this study was to clarify the clinical relevance of TMYS expression in urothelial carcinoma and to determine the relationship between TYMS expression and gene amplification. Desi

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12

Chmielewska-Kassassir, Małgorzata, Katarzyna Sobierajska, Wojciech M. Ciszewski, Jakub Kryczka, Andrzej Zieleniak, and Lucyna A. Wozniak. "Evening Primrose Extract Modulates TYMS Expression via SP1 Transcription Factor in Malignant Pleural Mesothelioma." Cancers 15, no. 20 (2023): 5003. http://dx.doi.org/10.3390/cancers15205003.

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Purpose: To determine the mechanism of EPE in downregulating TYMS in MPM cancer. Methods: The TYMS mRNA expression with epithelial-to-mesenchymal transition biomarkers and nuclear factor SP1 was assessed using the GEO database in a data set of MPM patients (GSE51024). Invasive MPM cell lines were in vitro models for the investigation of TYMS expression after EPE treatment. The tyms promoter SP1 binding sequences were determined using Genomatix v 3.4 software Electrophoretic mobility shift and dual-luciferase reporter assays revealed specific SP1 motifs in the interaction of EPE and reference c

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Sevim, Behlül, and Yusuf Cufadar. "Etlik Piliçlerde Karma Yeme Farklı Esansiyel Yağlar ve Karışımlarının İlavesinin Performans ve Karkas Özellikleri Üzerine Etkisi." Turkish Journal of Agriculture - Food Science and Technology 5, no. 8 (2017): 964. http://dx.doi.org/10.24925/turjaf.v5i8.964-968.1261.

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This study was conducted to determine the effect of dietary supplementation of thymus (Thymus vulgaris L.), rosemary (Rosmarinus officinalis L.) and French lavender (Lavandua stoechas L.) essential oils and their mixtures on body weight and body weight gain, feed consumption, feed conversion ratio, carcass characteristics in broiler. A total of one day old 640 broiler chicks (Ross 308) were used divided into 8 groups each having five replicates, ramdomly. There were 80 chicks in each experimental group. The experimental diets were consisted of control (0 mg/kg), addition to thymus essential oi

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Yang, Jian, Jingjing Zhang, Jingtian Chen, et al. "Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression." PLOS ONE 18, no. 9 (2023): e0290264. http://dx.doi.org/10.1371/journal.pone.0290264.

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Background Thymidylate synthase (TYMS) is involved in the malignant process of multiple cancers, and has gained much attention as a cancer treatment target. However, the mechanism in carcinogenesis of esophageal squamous cell cancer (ESCC) is little reported. The present study was to clear the biological roles and carcinogenic mechanism of TYMS in ESCC, and explored the possibility to use TYMS as a tumor marker in diagnosis and a drug target for the treatment of ESCC. Methods Stably TYMS-overexpression cells established by lentivirus transduction were used for the analysis of cell proliferatio

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Lutz, Florian, Nicolai Leege, Katharina Möller, et al. "Abstract 1047: Expression of TYMS in cancer: A tissue microarray study involving 6,613 cancers from 127 tumor entities." Cancer Research 84, no. 6_Supplement (2024): 1047. http://dx.doi.org/10.1158/1538-7445.am2024-1047.

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Abstract Thymidylate synthase (TS, TYMS) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) which is one of the nucleotides forming the DNA. TYMS is thus essential for DNA synthesis and represents an important target for several chemotherapeutic drugs including 5-fluorouracil (5-FU) and methotrexate. It has been suggested that tumors with low-levels of TYMS may show a better response to 5-FU than those with high-level expression. Literature data on TYMS expression in different cancer types is controversial, however. To better

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16

Lampe, Peter. "Die montanistischen Tymion und Pepouza im Lichte der neuen Tymioninschrift." Zeitschrift für Antikes Christentum 8, no. 3 (2005): 498–512. http://dx.doi.org/10.1515/zach.2005.8.3.498.

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17

Goodare, Julian. "The Scottish Witchcraft Act." Church History 74, no. 1 (2005): 39–67. http://dx.doi.org/10.1017/s0009640700109655.

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Few acts of the Scottish parliament can have had such deadly consequences as the following, passed on June 4, 1563: Anentis Witchcraftis.ITEM Forsamekill as the Quenis Majestie and thre Estatis in this present Parliament being informit, that the havy and abominabill superstitioun usit be divers of the liegis of this Realme, be using of Witchcraftis, Sorsarie and Necromancie, and credence gevin thairto in tymes bygane aganis the Law of God: And for avoyding and away putting of all sic vane superstitioun in tymes tocum: ¶ It is statute and ordanit be the Quenis Majestie, and thre Estatis foirsai

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18

Troncarelli Flores, Bianca C., Virgilio Souza e Silva, Emne Ali Abdallah, et al. "Molecular and Kinetic Analyses of Circulating Tumor Cells as Predictive Markers of Treatment Response in Locally Advanced Rectal Cancer Patients." Cells 8, no. 7 (2019): 641. http://dx.doi.org/10.3390/cells8070641.

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Neoadjuvant chemoradiation (NCRT) followed by total mesorectal excision is the standard treatment for locally advanced rectal cancer (LARC). To justify a non-surgical approach, identification of pathologic complete response (pCR) is required. Analysis of circulating tumor cells (CTCs) can be used to evaluate pCR. We hypothesize that monitoring of thymidylate synthase (TYMS) and excision repair protein, RAD23 homolog B (RAD23B), can be used to predict resistance to chemotherapy/radiotherapy. Therefore, the aims of this study were to analyze CTCs from patients with LARC who underwent NCRT plus s

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19

Szydłowska (oprac.), Mariola. "Batalia o Schillera i teatr we Lwowie: Teksty publicystyczne Tymona Terleckiego z lat 1930–1931." Pamiętnik Teatralny 66, no. 4 (2017): 184–263. http://dx.doi.org/10.36744/pt.2206.

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Teksty przedrukowane w tym artykule ukazały się po raz pierwszy w lwowskim Słowie Polskim w latach 1930-1931. Opatrzono je wstępem, w którym omówiono kontekst historyczny ich powstania. Teksty należą do wczesnego okresu twórczości wybitnego teatrologa Tymona Terleckiego, a jednocześnie rzucają światło na krótki, ale ważny epizod w dziejach lwowskiej sceny związany z Leonem Schillerem. Mimo że artykuły powstały z inspiracji redaktora naczelnego Słowa Polskiego Wacława Mejbauma, ujawniały także własne przekonania Terleckiego i dawały wyraz jego zaangażowaniu w tzw. „batalię o Schillera”. Chodził

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20

Ciszewski, Wojciech M., Małgorzata Chmielewska-Kassassir, Lucyna A. Wozniak, and Katarzyna Sobierajska. "Thymidylate Synthase Overexpression Drives the Invasive Phenotype in Colon Cancer Cells." Biomedicines 10, no. 6 (2022): 1267. http://dx.doi.org/10.3390/biomedicines10061267.

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Thymidylate synthase (TYMS) is the crucial enzymatic precursor for DNA biosynthesis and, therefore, the critical target for numerous types of chemotherapy, including the most frequently applied agent in colon cancer treatment 5-fluorouracil (5-FU). TYMS also seems to be associated with cancer metastasis and acquiring mesenchymal character by tumor cells during epithelial–mesenchymal transition (EMT). Based on that knowledge, we decided to investigate the role of TYMS in the modulation of invasive ability in colon cancer cells, where its effect on cancer metastasis has not been studied in detai

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21

Ioannou, Charalampia, Georgia Ragia, Ioanna Balgkouranidou, et al. "Gender-dependent association of TYMS-TSER polymorphism with 5-fluorouracil or capecitabine-based chemotherapy toxicity." Pharmacogenomics 22, no. 11 (2021): 669–80. http://dx.doi.org/10.2217/pgs-2021-0031.

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Aim: TYMS gene encodes for TS enzyme involved in 5-fluorouracil (5-FU) and capecitabine (CAP) metabolism. This study assessed the association of TYMS-TSER and 3RG>C polymorphisms with 5-FU/CAP adverse event (AE) incidence. Materials & methods: TYMS-TSER and 3RG>C polymorphisms were analyzed by use of PCR/PCR-RFLP in 313 5-FU/CAP-treated cancer patients. Results: Female TYMS-TSER 2R carriers were at increased risk for 5-FU/CAP AEs (odds ratio: 2.195; p = 0.032). 2R/2R genotype was the only factor that increased risk for delayed drug administration or therapy discontinuation (odds rati

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Awan, Saad, Girijesh K. Patel, Anu Singh Maharjan, et al. "Germline pharmacogenomics of thymidylate synthase gene in patients with gastrointestinal malignancies treated with fluoropyrimidines-based chemotherapy regimens." Journal of Clinical Oncology 37, no. 4_suppl (2019): 545. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.545.

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545 Background: Fluoropyrimidines are antimetabolites that target the S phase of the cell cycle. The active metabolite, 5-fluorodeoxyuridine monophosphate inhibits thymidylate synthase (TS) enzyme, thus preventing DNA synthesis and ultimately cell death. While controversy exists in the literature, polymorphism in the promoter region of thymidylate synthase gene (TYMS) that decrease TS expression has been associated with increased fluoropyrimidines-associated toxicities. This study explored the association between polymorphism in the promoter region of TYMS gene and fluoropyrimidines-associated

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23

Gu, Yulan, Chuandan Wan, Guoqiang Zhou, Jinlian Zhu, Zhiliang Shi, and Zhixiang Zhuang. "TYMSOS drives the proliferation, migration, and invasion of gastric cancer cells by regulating ZNF703 via sponging miR‐4739." Cell Biology International 45, no. 8 (2021): 1710–19. http://dx.doi.org/10.1002/cbin.11610.

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Dib, Peter Elias, Maria Guijarro, Patrick Kellish, et al. "Abstract 1657: Discovery of a first-in-class multifunctional TYMS non-classical antifolate inhibitors with potent in vivo activity that prolongs survival." Cancer Research 83, no. 7_Supplement (2023): 1657. http://dx.doi.org/10.1158/1538-7445.am2023-1657.

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Abstract Thymidylate synthase (TYMS/TS) is overexpressed in many cancer types and is commonly associated with advanced disease. TYMS catalyzes the de novo synthesis reaction of deoxythymidine monophosphate (dTMP), one of the building blocks of DNA. Although TYMS inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells exploit for drug resistance limiting overall benefit. Here we report a small molecule TYMS inhibitor and its two analogues that exhibit i) e

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Tan, Benjamin R., Fabienne Thomas, Robert J. Myerson, et al. "Thymidylate Synthase Genotype-Directed Neoadjuvant Chemoradiation for Patients With Rectal Adenocarcinoma." Journal of Clinical Oncology 29, no. 7 (2011): 875–83. http://dx.doi.org/10.1200/jco.2010.32.3212.

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Purpose Downstaging (DS) of rectal cancers is achieved in approximately 45% of patients with neoadjuvant fluorouracil (FU) -based chemoradiotherapy (CRT). Polymorphisms in the thymidylate synthase gene (TYMS) had previously defined two risk groups associated with disparate tumor DS rates (60% v 22%). We conducted a prospective single-institution phase II study using TYMS genotyping to direct neoadjuvant CRT for patients with rectal cancer. Patients and Methods Patients with T3/T4, N0-2, M0-1 rectal adenocarcinoma were evaluated for germline TYMS genotyping. Patients with TYMS *2/*2, *2/*3, or

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26

Olkowski, Erin, and Emily Tymus Ihrke. "Let Chaos In: Enacting Democracy in a Writing and Publishing Class." English Journal 94, no. 5 (2005): 57–63. http://dx.doi.org/10.58680/ej20054262.

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High school teachers Erin Olkowski and Emily Tymus Ihrke know from personal experience the benefits to students of democratic classrooms and the associated difficulties. They share their six principles for making a publications class work democratically.

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Baldeo, Candice, Caren Hughes, Faisal Shahjehan, Saivaishnavi Kamatham, and Pashtoon Murtaza Kasi. "Identifying the importance of integrating routine pharmacogenomic testing for UGT1A1 and DPYD/tyms genetic variants in patients receiving irinotecan and/or 5-fluorouracil chemotherapy." Journal of Clinical Oncology 37, no. 4_suppl (2019): 660. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.660.

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660 Background: Adverse toxicities to chemotherapy remain a limiting factor for patients receiving treatment for malignancies. In gastrointestinal cancers, particularly metastatic colorectal cancer, the majority of front line treatment remains chemotherapy containing 5-fluorouracil and/or irinotecan. One particular cause that can predispose a patient to increased toxicity from 5-fluorouracil is genetic variation in the DPYD gene, as well as TYMS gene. Similarly, genetic variation in the UGT1A1 gene can increase the risk of irinotecan toxicity. These gene variations may have major implications

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Goldstein, Harvey. "Rasch measurement: a response to Payanides, Robinson and Tymms." British Educational Research Journal 41, no. 1 (2015): 176–79. http://dx.doi.org/10.1002/berj.3170.

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Saif, Wasif M., Ruchi Hamal, Nauman Saleem Siddiqui, Antonia Maloney, Lilian Chen, and Kathryn Huber. "Alternative chemoradiotherapy to treat locally advanced (LA) anal carcinoma (AC) in patients (pts) with mutations in thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) genes: A case series." Journal of Clinical Oncology 37, no. 4_suppl (2019): 605. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.605.

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605 Background: 5-FU and mitomycin-C (MMC) with radiotherapy (RT) remain an established treatment for pts with LA (T2-4, N0-1, M0 or T1-4, N2-3, M0) AC. Genetic mutations in 2 major metabolizing enzymes for 5-FU; DPYD and TYMS have been associated with clinical response and toxicity. However their place in treatment of AC remains undetermined. Methods: We retrospectively reviewed 21 pts with LA AC treated between 2012 - 2018. All pts were treated with 5-FU 1,000mg/m2/day continuous IV infusion 1–4 and 29–32, MMC 10mg/m2 IV bolus Days 1 and 29 plus RT. Acute toxicity was recorded and discussed

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Tabbernee, William. "Portals of the Montanist New Jerusalem: The Discovery of Pepouza and Tymion." Journal of Early Christian Studies 11, no. 1 (2003): 87–93. http://dx.doi.org/10.1353/earl.2003.0014.

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Drubin, David A., Anne-Katrin Hess, Natalie L. Catlett, Alessandro Di Cara, Yvonne Wettergren, and Roger Tell. "MYC as a candidate upstream controller involved in TYMS gene expression and 5-FU/folate treatment efficacy in colorectal cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e15512-e15512. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15512.

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e15512 Background: One of the target enzymes of 5-fluorouracil (5-FU)-based therapies is thymidylate synthase (TS) encoded by the TYMS gene. To enhance the effect of 5-FU, a folate analogue is often provided as part of the treatment. In this context, it has previously been shown in the ISO-CC-005 clinical study that TYMS gene expression can be predictive of response to 5-FU + folate analogue Arfolitixorin. Methods: To better understand the role of TYMS expression as a predictor of response to 5-FU + folate-based therapies and identify potential mechanisms and biomarkers of sensitivity/resistan

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Silva, Virgílio Souza e., Emne Ali Abdallah, Bianca de Cássia Troncarelli Flores, et al. "Molecular and Dynamic Evaluation of Proteins Related to Resistance to Neoadjuvant Treatment with Chemoradiotherapy in Circulating Tumor Cells of Patients with Locally Advanced Rectal Cancer." Cells 10, no. 6 (2021): 1539. http://dx.doi.org/10.3390/cells10061539.

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The heterogeneity of response to neoadjuvant chemoradiotherapy (NCRT) is still a challenge in locally advanced rectal cancer (LARC). The evaluation of thymidylate synthase (TYMS) and RAD23 homolog B (RAD23B) expression in circulating tumor cells (CTCs) provides complementary clinical information. CTCs were prospectively evaluated in 166 blood samples (63 patients) with LARC undergoing NCRT. The primary objective was to verify if the absence of RAD23B/TYMS in CTCs would correlate with pathological complete response (pCR). Secondary objectives were to correlate CTC kinetics before (C1)/after NCR

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Kim, Nayeon, and Changwon Yang. "Sodium Butyrate Inhibits the Expression of Thymidylate Synthase and Induces Cell Death in Colorectal Cancer Cells." International Journal of Molecular Sciences 25, no. 3 (2024): 1572. http://dx.doi.org/10.3390/ijms25031572.

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The most commonly used chemotherapy for colorectal cancer (CRC) is the application of 5-fluorouracil (5-FU). Inhibition of thymidylate synthase (TYMS) expression appears to be a promising strategy to overcome the decreased sensitivity to 5-FU caused by high expression of TYMS, which can be induced by 5-FU treatment. Several compounds have been shown to potentially inhibit the expression of TYMS, but it is unclear whether short-chain fatty acids (SCFAs), which are naturally produced by bacteria in the human intestine, can regulate the expression of TYMS. Sodium butyrate (NaB) is the most widely

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Meier, Patricia, Maité Calisti, Inge Werner, et al. "Validity and Reliability of the Posturographic Outcomes of a Portable Balance Board." Sensors 25, no. 5 (2025): 1309. https://doi.org/10.3390/s25051309.

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In view of the frequent use of the portable balance board (Tymo®, Tyromotion, Graz, Austria) in neurorehabilitation, the objective of this study is to assess its posturographic validity and reliability in comparison to a floor-embedded force platform (AMTI, Watertown, MA, USA), as well as its clinical validity in stroke patients. To evaluate posturographic validity, thirty healthy participants were tested in four different measurement conditions (M1–M4: standing with/without a balance pad, eyes open/closed) while simultaneously measuring with both devices placed on top of each other. Clinical

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Aysicom Paraguay, Muhammad, Ruuhwan Ruuhwan, and Teuku Mufizar. "Perancangan UI/UX Website Tymo Studio Menggunakan Metode Design Thinking." Informatics and Digital Expert (INDEX) 7, no. 1 (2025): 48–54. https://doi.org/10.36423/index.v7i1.2101.

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Tymo studio sudah berdiri sejak tahun 2019, menawarkan beragam layanan fotografi dari mulai foto keluarga hingga pernikahan. Perkembangan pesat teknologi digital telah mendorong berbagai sektor usaha untuk memanfaatkan internet sebagai media utama dalam pemasaran dan komunikasi dengan pelanggan. Tymo Studio menyadari pentingnya memiliki platform digital seperti website, untuk memasarkan layanan mereka secara efektif di internet. Untuk saat ini, Tymo Studio mengandalkan Social Media sebagai sarana pemasaran. Sebelumnya, Tymo Studio sudah pernah merancang website mereka sendiri, tapi batal dipub

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Evgeny, A. Reshetnikov Inna N. Sorokina Evgeny N. Krikun Lyubov S. Orlova Valery I. Evdokimov Alexandr A. Dolgikov. "CANDIDATE GENES AND CLINICAL-LABORATORY PARAMETERS IN PREGNANT WOMEN WITH PREECLAMPSIA." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6970–74. https://doi.org/10.5281/zenodo.1324374.

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<em>Objectives: They studied the associations of genetic polymorphisms with clinico-laboratory indicators among pregnant women with preeclampsia depending on hereditary complication.</em> <em>Materials and Methods: The study was conducted among 274 pregnant women with preeclampsia. They studied the polymorphisms of five folate cycle genes (+677</em><em>С</em><em>></em><em>Т</em><em> M</em><em>Т</em><em>HFR (rs1801133), +1298</em><em>А</em><em>></em><em>С</em><em> M</em><em>Т</em><em>HFR (rs1801131), -1053</em><em>С</em><em>></em><em>Т</em><em> </em><em>Т</em><em>YMS (rs699517), IVS6-6

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Yuan, Stephen Hsien-Chi, Shih-Chieh Chang, Pei-Yi Chou, Youngsen Yang, and Hao-Ping Liu. "The Implication of Serum Autoantibodies in Prognosis of Canine Mammary Tumors." Animals 12, no. 18 (2022): 2463. http://dx.doi.org/10.3390/ani12182463.

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Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-link

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Vijayakurup, Vinod, Benjamin Meyer, Akbar Nawab, Frederic J. Kaye, Maria V. Guijarro, and Maria Zajac-Kaye. "Abstract 2733: TYMS as a novel target for AAV-based therapy." Cancer Research 83, no. 7_Supplement (2023): 2733. http://dx.doi.org/10.1158/1538-7445.am2023-2733.

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Abstract The purpose of this study is to develop a strategy for treating pancreatic neuroendocrine tumor (PanNET) through blocking Thymidylate Synthase (TYMS or TS), a DNA metabolic enzyme. Elevated TYMS levels are frequently observed in human PanNET and are associated with worse prognosis and resistance to cytotoxic agents such as 5FU. Elevated TYMS levels directly promote tumorigenesis in vitro and ectopic expression of human TS (hTS) in transgenic mice promotes adenoma development in the endocrine pancreas in vivo. Pancreatic islet tumor formation in hTS transgenic mice occurred with a long

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Watson, R. G., F. Muhale, L. Thorne, et al. "Association of copy number variants in colorectal liver metastases with 5-fluorouracil resistance." Journal of Clinical Oncology 27, no. 15_suppl (2009): e14502-e14502. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e14502.

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e14502 Background: Resistance to 5-fluorouracil (5-FU) represents a major contributor to cancer-related mortality in advanced colorectal cancer patients. Previous work has shown that thymidylate synthase (TYMS) copy gains were associated with significantly shorter survival, while increased expression of thymidine phosphorylase (TP) led to greater sensitivity to 5-FU in vitro. We assessed TYMS and TP copy number in colorectal liver metastases from untreated patients and patients treated with 5-FU in an effort to elucidate the underlying molecular mechanisms for 5-FU resistance. Methods: Liver m

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Tymms, Peter. "The impact of teaching on salaries." Early Years Educator 24, no. 1 (2023): 12. http://dx.doi.org/10.12968/eyed.2023.24.1.12.

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Peter Tymms, Emeritus Professor at Durham University, discusses a report looking at the economic benefits of high-quality early years teaching for children later in life which he co-authored with the Department for Education, entitled The economic benefits of effective reception classes in England, published earlier this year.

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Haslam, Jason. "Discovering Identity in James Tyman’s Inside Out: An Autobiography of a Native Canadian." ESC: English Studies in Canada 26, no. 4 (2000): 473–92. http://dx.doi.org/10.1353/esc.2000.0041.

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Sheibak, V., A. Pavlyukovets, V. Smirnov, and L. Sheibak. "Free amino acids of tymus after intragastric introduction of infesol40." Immunopathology, Allergology, Infectology, no. 4 (October 1, 2017): 6–10. http://dx.doi.org/10.14427/jipai.2017.4.6.

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Xu, Yu-Lian, Xiao-Ming Jiang, Le-Le Zhang, Xiuping Chen, Zhang-Jian Huang, and Jin-Jian Lu. "Establishment and Characterization of Pemetrexed-resistant NCI-H460/PMT Cells." Anti-Cancer Agents in Medicinal Chemistry 19, no. 6 (2019): 731–39. http://dx.doi.org/10.2174/1871520619666190307120441.

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Background:Pemetrexed (PMT) is a multitargeted antifolate agent that is used for treating patients with Non-Small Cell Lung Cancer (NSCLC). However, patients have presented clinical responses of drug resistance to PMT.Objective:This study aimed to explore the underlying mechanisms of PMT resistance in NSCLC cells.Methods:PMT-resistant NCI-H460/PMT cells were established by treating with PMT in a concentrationescalation manner. MTT assay and colony formation were performed to detect cell proliferation. Immunofluorescence was used to detect the expression of Ki-67. Transwell assay was performed

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Liang, Guibin, Menghao Zeng, Min Gao, et al. "lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients." Oxidative Medicine and Cellular Longevity 2022 (January 17, 2022): 1–16. http://dx.doi.org/10.1155/2022/9369035.

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Background. Sepsis is one of the major causes of death worldwide, and its high mortality and pathological complexity hinder early accurate diagnosis. We aimed to investigate lncRNA IGF2-AS and HMGA1 effects on pyroptosis of endothelial progenitor cells (EPCs) in sepsis patients and the mechanisms involved. Methods. Blood samples from sepsis patients and healthy subjects were collected, and EPCs were isolated and identified. We constructed cell lines that knocked down lncRNA IGF2-AS, HMGA1, and TYMS. Furthermore, lncRNA IGF2-AS was overexpressed. Subsequently, dNTP treatment with different conc

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Chi, Jeffrey, Nausheen Hakim, Hasan Rehman, et al. "A prospective pilot study of pharmacogenetic-based dosing of 5-fluouracil (5-FU) and irinotecan (IRI) in patients (pts) with gastrointestinal (GI) malignancies." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16138-e16138. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16138.

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e16138 Background: 5-FU and IRI are core components of chemotherapies for GI malignancies. Previous studies have shown that mutations in DPYP and TYMS predispose the pts to 5-FU toxicities. Mutations in UGT1A1 predispose pts to increased IRI toxicities. Retrospective data suggest that these mutations may have implications in selecting dosage and/or schedule of 5-FU and IRI. We present here a prospective study of upfront pharmacogenetic testing with tailored dose of respective drugs in pts with these mutations. Methods: Pts with GI malignancies were tested for DPYD, TYMS and UGT1A1 mutations be

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Schwab, Matthias, Ulrich M. Zanger, Claudia Marx, et al. "Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group." Journal of Clinical Oncology 26, no. 13 (2008): 2131–38. http://dx.doi.org/10.1200/jco.2006.10.4182.

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Purpose To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate reductase (MTHFR ) and of nongenetic factors for severe leukopenia, diarrhea, and mucositis related to fluorouracil (FU) treatment. Patients and Methods A multicenter prospective clinical trial included 683 patients with cancer treated with FU monotherapy. Toxicity was documented according to World Health Organization grades. DPYD, TYMS, and MTHFR genotypes were determined, and DPYD was resequenced in patients with severe toxicity. Res

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&NA;. "TYMS gene polymorphism predicts fluorouracil toxicity." Inpharma Weekly &NA;, no. 1456 (2004): 21. http://dx.doi.org/10.2165/00128413-200414560-00052.

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&NA;. "TYMS gene polymorphism predicts fluorouracil toxicity." Reactions Weekly &NA;, no. 1020 (2004): 5. http://dx.doi.org/10.2165/00128415-200410200-00014.

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Sundbaum, Johanna Karlsson, Eva Baecklund, Niclas Eriksson, Pär Hallberg, Hugo Kohnke, and Mia Wadelius. "MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis." Pharmacogenomics 21, no. 5 (2020): 337–46. http://dx.doi.org/10.2217/pgs-2019-0186.

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Aims: To investigate whether variants of MTHFR, TYMS and SLCO1B1 are associated with ALT elevation in rheumatoid arthritis patients starting methotrexate (MTX). Patients & methods: Clinical and laboratory data were collected from the start of MTX treatment. Genotyping of MTHFR, TYMS and SLCO1B1 was performed. Univariate and multiple logistic regression were used for statistical analysis. Results: 34 out of 369 patients experienced ALT >1.5 × ULN less than 6 months from start. MTHFR A1298C (rs1801131) was nominally associated with an ALT >1.5 × ULN within 6 months after the start of M

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Gallegos-Arreola, Martha Patricia, Guillermo Moises Zúñiga-González, Josefina Yoaly Sánchez-López, et al. "TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A mutation genes in Mexican colorectal cancer patients." Acta Biochimica Polonica 65, no. 2 (2018): 227–34. http://dx.doi.org/10.18388/abp.2017_2338.

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Objetive: To examine the association between TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A mutation by comparing healthy subjects with colorectal cancer (CRC) patients from a Mexican population. Method: The genotyping of the 2R/3R was performed by polymerase chain reaction (PCR) and -[IVS]14+1G>A mutation by real-time PCR analysis. Results: The observed frequencies of the TYMS 2R3R polymorphism and the -[IVS]14+1G>A mutation on DPYD did not indicate an increased risk for CRC (p>0.05). An association between genotype and disease was evident. The distributions of the 2R/2R genotype an

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