Academic literature on the topic 'Tympanic membrane perforations'

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Journal articles on the topic "Tympanic membrane perforations"

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Erkilet, E., M. Koyuncu, S. Atmaca, and M. Yarim. "Platelet-rich plasma improves healing of tympanic membrane perforations: experimental study." Journal of Laryngology & Otology 123, no. 5 (2008): 482–87. http://dx.doi.org/10.1017/s0022215108003848.

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AbstractObjective:The aim of this study was to investigate the effect of local application of platelet-rich plasma to perforated rat tympanic membranes, in terms of healing time and histopathological outcome.Methods:Eighty-eight tympanic membranes of 44 rats were given a standard 3 mm perforation, and platelet-rich plasma was applied to the right tympanic membrane perforations. The left tympanic membranes were left to heal spontaneously, as controls. The 44 rats were divided into two groups. In group one, comprising 20 rats, daily otomicroscopic examination of the tympanic membrane perforations was performed. The 24 rats in group two were subdivided into four subgroups of six rats each; these subgroups were sacrificed sequentially on days three, seven, 14 and 28 for histopathological examination, regardless of tympanic membrane healing stage.Results:In group one, the mean tympanic membrane healing times for tympanic membrane perforations receiving platelet-rich plasma and controls were respectively 10.2 ± 2.1 and 13.0 ± 2.9 days (mean ± standard deviation). This difference was statistically significant (p < 0.001). In group two, histopathological evaluation of tympanic membrane perforation healing at days three, seven, 14 and 28 did not reveal any statistically significant difference, individually or within the four groups as a whole.Conclusion:These findings suggest that earlier healing of tympanic membrane perforations occurred in the platelet-rich plasma group compared with the control group. These findings suggest that platelet-rich plasma is effective in accelerating tympanic membrane perforation healing, and that it may be effective in human subjects, particularly as it is an autologous material.
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Lavanya, M. "A STUDY ON CORRELATION OF SIZE AND SITE OF TYMPANIC MEMBRANE PERFORATION WITH DEGREE OF CONDUCTIVE HEARING LOSS IN CHRONIC OTITIS MEDIA." UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY VOLUME 9, ISSUE 1 (2021): 19–23. http://dx.doi.org/10.36611/upjohns/volume9/issue1/4.

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Background: Tympanic membrane perforations are common cause of hearing loss. This study was designed to analyze the relation between tympanic membrane perforation and conductive hearing loss. Materials and Methods: In this prospective study, patients with dry tympanic membrane perforations of safe type were included. The patients were divided into groups in according to size, site and duration of perforation. Based on the inclusion and exclusion criteria a total of 100 patients were included in this study. All the patients clinical data was analyzed statistically using paired t-test. Results:Hearing loss increased as the size of perforation increased. Posterior quadrant perforations were associated with more hearing loss as compared to anterior quadrant perforations. Also duration of disease was in linear relation with mean hearingloss. Conclusions: The degree of conductive hearing loss as a result of tympanic membrane perforation would be expected with the size, site and duration of perforation. Keywords: Tympanic membrane, Conductive hearing loss, Perforation, hearing loss, posterior quadrant, ear.
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Aneesa, Mirza, Samreen Siraj, and Arshid Ali. "Correlation of tympanic membrane perforations with hearing loss." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 5 (2019): 1213. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20193857.

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<p class="abstract"><strong>Background:</strong> Tympanic membrane perforations are common cause of hearing loss. This study was designed to analyze the relation between tympanic membrane perforation and hearing loss.</p><p class="abstract"><strong>Methods:</strong> In this prospective study, patients with dry tympanic membrane perforations of safe type were included. The patients were divided into groups in according to size, site and duration of perforation. </p><p class="abstract"><strong>Results:</strong> 49 patients with 70 dry tympanic membrane perforations were studied. Data was analyzed statistically using paired t-test. Hearing loss increased as the size of perforation increased. Posterior quadrant perforations were associated with more hearing loss as compared to anterior quadrant perforations. Also duration of disease was in linear relation with mean hearing loss.</p><strong>Conclusions:</strong>The degree of conductive hearing loss as a result of tympanic membrane perforation would be expected with the size, site and duration of perforation.<p> </p>
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Lou, Z. C., and Z. H. Lou. "A moist edge environment aids the regeneration of traumatic tympanic membrane perforations." Journal of Laryngology & Otology 131, no. 7 (2017): 564–71. http://dx.doi.org/10.1017/s0022215117001001.

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AbstractObjective:To review the history of moist therapy used to regenerate traumatic tympanic membrane perforations.Study design:Literature review.Methods:The literature on topical agents used to treat traumatic tympanic membrane perforations was reviewed, and the advantages and disadvantages of moist therapy were analysed.Results:A total of 76 studies were included in the analysis. Topical applications of certain agents (e.g. growth factors, Ofloxacin Otic Solution, and insulin solutions) to the moist edges of traumatic tympanic membrane perforations shortened closure times and improved closure rates.Conclusion:Dry tympanic membrane perforation edges may be associated with crust formation and centrifugal migration, delaying perforation closure. On the contrary, moist edges inhibit necrosis at the perforation margins, stimulate proliferation of granulation tissue and aid eardrum healing. Thus, moist perforation margins upon topical application of solutions of appropriate agents aid the regeneration of traumatic tympanic membrane perforations.
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Spandow, Odd, and Sten Hellström. "Animal Model for Persistent Tympanic Membrane Perforations." Annals of Otology, Rhinology & Laryngology 102, no. 6 (1993): 467–72. http://dx.doi.org/10.1177/000348949310200611.

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Topically applied hydrocortisone was used to develop an animal model for persistent tympanic membrane (TM) perforations. Hydrocortisone suspension was applied on the margins of TM perforations of standardized size in rats once daily for 10 days. The healing patterns of the TMs were mapped weekly and, when the perforations were about to close, daily. After 50 days, all hydrocortisone-treated perforations were open, whereas the controls closed within 9 to 12 days. At 3 months, when one third of the perforations still were open, the TMs were studied by otomicroscopy and light microscopy. All TMs were thickened and covered by keratin and wax. The thickened epidermal layer at the border of the TM perforations that remained open also draped the surface of the perforation facing the middle ear cavity. The thickened connective tissue layer contained abundant fibroblasts with their axes of length oriented at random. Both application of 1.4% hyaluronan and wounding of the perforation border enhanced the healing rate of the hydrocortisone-induced chronic TM perforation.
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Amoils, C. Philip, Robert K. Jackler, Henry Milczuk, Kevin E. Kelly, and Keli Cao. "An Animal Model of Chronic Tympanic Membrane Perforation." Otolaryngology–Head and Neck Surgery 106, no. 1 (1992): 47–55. http://dx.doi.org/10.1177/019459989210600127.

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Previous investigations into the healing and reconstruction of tympanic membrane (TM) perforations have involved animal models with acute TM perforations. A problem with the acute TM perforation model is that most acute TM perforations will heal spontaneously, both in animals and human beings. A second inadequacy of acute perforation models is that they are not analogous to the salient problem in human beings: Longstanding TM perforation. The ideal animal model must have a TM perforation that is permanent, well-eplthelialized, and free from infection. The perforation must also be subtotal to preserve a rim of membrane for experimental manipulations, in the chinchilla, we have identified a hardy animal with a short, wide ear canal and relatively large tympanic membranes. Thermal myringectomy, followed by medial infolding of TM microflaps, has resulted in permanent, subtotal chronic TM perforations in the chinchilla animal model. Of the 19 chinchillas (38 TMs) perforated, chronic subtotal perforations were created in 32 ears, 6 to 8 weeks after the initial procedure (84% success). Persistent infection or TM regeneration despite reperforation was recorded in 6 ears (16%) failure). This model is currently being used to assess various biomembrane scaffolds impregnated with growth-promoting substances in the regeneration of a physiologically sound TM, initially in our animal model and then in human beings. We envision the development of a biomembrane disc impregnated with biorecombinant growth factors that may provide a simple office technique for the repair of chronic, non-infected TM perforations.
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Halik, Jerry J., and G. D. L. Smyth. "Long-Term Results of Tympanic Membrane Repair." Otolaryngology–Head and Neck Surgery 98, no. 2 (1988): 162–69. http://dx.doi.org/10.1177/019459988809800211.

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Long-term results of tympanic membrane repair were analyzed in 605 patients operated upon from 1970 to 1975. By survival life table analysis, 81% closure of perforations was found at 11 years, and only 74% of patients had normally healed tympanic membranes. Children less than 10 years of age and with anterior perforations healed more poorly. A second group of patients—all with anterior perforations operated upon from 1982 to 1984—showed autologous temporalis fascia to be superior to homograft dura as the graft material. Analysis of results also showed a 60% chance of perforation closure at revision operation. These results are believed to represent an accurate and realistic assessment of tympanic membrane repair by use of survival life table analysis.
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Sahni, Dimple, Bikramjit Singh, K. S. Uppal, Sanjeev Bhagat, Dinesh Sharma, and Girish Dogra. "Study of effect of 1% sodium hyaluronate application on tympanic membrane perforation." International Journal of Otorhinolaryngology and Head and Neck Surgery 4, no. 5 (2018): 1246. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20183695.

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<p class="abstract"><strong>Background:</strong> Topical applications of hyaluronic acid have been found to have beneficial effects on closure of tympanic membrane perforations.<strong> </strong>The aim of the study was to evaluate the role of 1% sodium hyaluronate in the repair of small or medium sized dry central tympanic membrane perforation and improvement in hearing following closure of tympanic membrane perforation.</p><p class="abstract"><strong>Methods:</strong> 50 patients with dry central perforation of inflammatory or traumatic origin were taken up. Maximum of 4 applications of 1% sodium hyaluronate were given at weekly intervals. Final mapping for closure of tympanic membrane perforation and hearing assessment was done after 3 months. </p><p class="abstract"><strong>Results:</strong> 26 perforations closed completely while 18 perforations showed significant reduction in size. Thus 44 or 88% perforations showed positive response to 1% sodium hyaluronate application. Hearing Improvement was observed on pure tone audiometry with the average hearing gain in patients after complete closure of tympanic membrane perforation was 12.40 dB with p value of 0.001.</p><p class="abstract"><strong>Conclusions:</strong> Study showed the beneficial effects of 1% sodium hyaluronate application in closure of small and medium size perforations of tympanic membrane perforation and improvement in hearing.</p><p class="abstract"> </p>
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Levine, Sam, Kathleen Daly, and G. Scott Giebink. "Tympanic Membrane Perforations and Tympanostomy Tubes." Annals of Otology, Rhinology & Laryngology 103, no. 5_suppl (1994): 27–30. http://dx.doi.org/10.1177/00034894941030s508.

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Tympanoplasty and tympanostomy tubes were developed at the same time and have dramatically changed the treatment of chronic middle ear disease. One hundred forty-nine children who had tubes inserted between ages 6 months and 8 years for chronic otitis media with effusion have been prospectively followed up for an average of 4 years. Fourteen percent developed tympanic membrane perforations. No preoperative factor completely predicted the development of perforation. a majority of the perforations closed spontaneously. Three ears had noncontiguous observations of perforations during follow-up. The implications of these findings are discussed with respect to tympanoplasty.
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Matsuda, Y., T. Kurita, Y. Ueda, S. Ito, and T. Nakashima. "Effect of tympanic membrane perforation on middle-ear sound transmission." Journal of Laryngology & Otology 123, S31 (2009): 81–89. http://dx.doi.org/10.1017/s0022215109005155.

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AbstractTympanic membrane perforation causes a sound conduction disturbance, and the size of this conduction disturbance is proportional to the perforation area. However, precise evaluation of perforation size is difficult, and there are few detailed reports addressing this issue. Furthermore, such evaluation becomes more difficult for irregularly shaped perforations. This study conducted a quantitative evaluation of tympanic membrane perforations, using image analysis equipment.A significant correlation was found between the degree of sound conduction disturbance and the perforation area; this correlation was greater at low frequencies following a traumatic perforation. The conductive disturbance associated with chronic otitis media was significantly greater at low frequencies. Circular perforations caused only minor conduction disturbance. Perforations in the anteroinferior quadrant were associated with greater conduction disturbance. Traumatic spindle-shaped perforations and malleolar perforations were associated with greater conduction disturbance.
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Dissertations / Theses on the topic "Tympanic membrane perforations"

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Rahman, Anisur. "Healing of tympanic membrane perforations : an experimental study /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-243-9/.

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Hansson, Annika. "The effects of plasminogen deficiency on the healing of tympanic membrane perforations." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1100.

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Voss, Susan E. (Susan Elizabeth). "Effects of tympanic-membrane perforations on middle-ear sound transmission : measurements, mechanisms, and models." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/9921.

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Shen, Yue. "Plasminogen : a novel inflammatory regulator that promotes wound healing." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68755.

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The plasminogen activator (PA) system has been shown to be intimately involved in wound healing. However, the role of this system in the initiation and resolution of inflammation during healing process remained to be determined. The aims of this thesis were to investigate the molecular mechanism underlying the interaction between the PA system and the inflammatory system during wound healing and to explore the therapeutic potential of plasminogen in various wound-healing models. The role of plasminogen in the inflammatory phase of the healing process of acute and diabetic wounds was studied first. Our data showed that administration of additional plasminogen to wild-type mice accelerates the healing of acute wounds. After injury, both endogenous and exogenous plasminogen are bound to inflammatory cells and are transported to the wound site, which leads to activation of inflammatory cells. In diabetic db/db mice, wound-specific accumulation of plasminogen does not take place and the inflammatory response is impaired. However, when additional plasminogen is injected, plasminogen accumulates in the wound, the inflammatory response is enhanced, the signal transduction cascade is activated and the healing rate is significantly increased. These results indicate that administration of plasminogen may be a novel therapeutic strategy to treat different types of wounds, especially chronic wounds in diabetes. The role of plasminogen at the later stage of wound healing was also studied in plasminogen-deficient mice. Our data showed that even if re-epithelialization is achieved in these mice, a prolonged inflammatory phase with abundant neutrophil accumulation and persistent fibrin deposition is observed at the wound site. These results indicate that plasminogen is also essential for the later phases of wound healing by clearing fibrin and resolving inflammation. The functional role of two physiological PAs during wound healing was further studied in a tympanic membrane (TM) wound-healing model. Our data showed that the healing process was clearly delayed in urokinase-type PA (uPA)-deficient mice but not in tissue-type PA (tPA)-deficient mice. Less pronounced keratinocyte migration, abundant neutrophil accumulation and persistent fibrin deposition were observed in uPA-deficient mice. These results indicate that uPA plays a central role in the generation of plasmin during the healing of TM perforations. Finally the therapeutic potential of plasminogen in the TM wound-healing model was studied. Our data showed that local injection of plasminogen restores the ability to heal TM perforations in plasminogen-deficient mice in a dose-dependent manner. Plasminogen supplementation also potentiates healing of acute TM perforations in wild-type mice, independent of the administration method used. A single local injection of plasminogen in plasminogen-deficient mice can initiate healing of chronic TM perforations resulting in a closed TM with a continuous but rather thick outer keratinocyte layer. Three plasminogen injections lead to a completely healed TM with a thin keratinizing squamous epithelium covering a connective tissue layer that can start to reorganize and further mature to its normal appearance. In conclusion, our results suggest that plasminogen is a promising drug candidate for the treatment of chronic TM perforations in humans.  Taken together, our data indicate that plasminogen is a novel inflammatory regulator that promotes wound healing.
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Ramalho, Jeanne da Rosa Oiticica. ""Cicatrização de perfurações subagudas de membrana timpânica de chinchilas tratadas com fator de crescimento epitelial e pentoxifilina"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-12042006-162203/.

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O efeito do fator de crescimento epitelial e da pentoxifilina, isolados ou em associação, foi avaliado em perfurações subagudas de membranas timpânicas de chinchilas, comparando-se ao grupo controle. O fator de crescimento epitelial auxiliou o processo de cicatrização de perfurações subagudas de membranas timpânicas, o que não se observou com a pentoxifilina. O percentual de cicatrização das perfurações foi de 30,3%, 3,6%, 16,5% e 8,7% nos grupos fator de crescimento epitelial, pentoxifilina, fator de crescimento epitelial com pentoxifilina e controle, respectivamente<br>The effect of epidermal growth factor and pentoxifylline, in combination or alone, was evaluated in chinchillas with subacute tympanic membrane perforations, and compared with a control group. Epidermal growth factor helped in the healing of subacute tympanic membrane perforations, but the same was not observed for pentoxifylline. The healing rate of perforations was 30.3%, 3.6%, 16.5% and 8.7% for the following groups: epidermal growth factor, pentoxifylline, epidermal growth factor with pentoxifylline and untreated controls, respectively
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Araújo, Marcos Miranda de. "Efeitos da utilização de insulina e de um implante transitório de biomembrana de látex natural, derivado da seringueira Hevea brasiliensis, em um modelo experimental de perfuração traumática de membrana timpânica." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17150/tde-20012013-151842/.

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Nos últimos anos, houve uma tendência na busca por substâncias reguladoras que pudessem otimizar o processo de cicatrização de membranas timpânicas (MTs) perfuradas. Objetivos: Determinar os efeitos da utilização da insulina tópica e da biomembrana de látex natural, de forma isolada e em associação, no processo de cicatrização de perfurações traumáticas de MTs. Materiais e Métodos: MTs de 61 ratos Wistar foram perfuradas nas porções anterior e posterior ao cabo do martelo. Os animais foram divididos em quatro grupos: Controle, Insulina, Látex e Insulina+Látex. No grupo Insulina, as perfurações foram tratadas com uso tópico de insulina regular. No grupo Látex, tratadas com biomembrana de látex natural. No grupo Insulina+Látex, tratadas com associação da insulina e da biomembrana de látex. As MTs foram avaliadas por técnicas histológicas com três, cinco e sete dias após sua perfuração traumática. Foram analisadas as morfometrias das espessuras das camadas epitelial, fibrosa e mucosa; tamanho da perfuração; área de secção transversal da MT; avaliação semiquantitativa e qualitativa da produção de colágeno por microscopia de polarização; e avaliação imuno-histoquímica das células epiteliais, dos miofibroblastos e da vascularização. Resultados: A insulina e a biomembrana de látex anteciparam o fechamento das perfurações traumáticas de MTs (p<0,01); estimularam precocemente o aumento da espessura da camada epitelial externa (p<0,01); promoveram aumento precoce da espessura da camada fibrosa (p<0,01); contribuíram para a maior identificação do anticorpo anti-panqueratina como marcador epitelial (p<0,05); aumentaram a marcação do anticorpo anti-alfa-actina de músculo liso (p<0,05), caracterizando maior proliferação de miofibroblastos. A insulina, isoladamente, provocou maior formação do colágeno tecidual (p<0,05), com fibras colágenas mais espessas e melhor organizadas (p<0,05). Conclusão: A insulina e a biomembrana de látex natural, de forma isolada e em associação, aceleraram o processo de cicatrização de perfurações traumáticas de MTs.<br>In recent years, there has been a tendency to search for regulatory substances that can optimize the healing process of perforated tympanic membranes (TMs). Objectives: To determine the effects of using topical insulin and natural latex biomembrane, alone or in combination, in the healing process of traumatic perforations of TMs. Methods: TMs of 61 Wistar rats were perforated in two sections, anterior and posterior to the malleus. The rats were divided into 4 groups: Control, Insulin, Latex, and Insulin+Latex. The Insulin group was treated with topical regular insulin. The Latex group was treated with natural latex biomembrane. The Insulin+Latex group was treated with a combination of insulin plus latex biomembrane. The TMs were histologically examined 3, 5, and 7 days post-perforation through morphometric analysis of the thickness of the epithelial, fibrous, and mucosal layers; size of the perforation; cross sectional area of the TM; semiquantitative and qualitative evaluation of the collagen production by polarization microscopy, and immunohistochemical evaluation of epithelial cells, myofibroblasts, and vascularization markers. Results: Insulin and latex biomembrane accelerated the healing process of the perforated TMs (p<0.01); stimulated early thickening of the outer epithelial layer (p<0.01); promoted premature increase in the thickness of the fibrous layer (p<0.01); contributed to a larger identification of anti-pankeratin antibody as epithelial marker (p<0.05); increased labeling of anti-alpha smooth muscle actin antibody (p<0.05), indicating greater proliferation of myofibroblasts. When insulin was used alone, it resulted in greater formation of collagen tissue (p<0.05), with thicker and better-organized collagen fibers (p<0.05). Conclusion: Insulin and natural latex biomembrane, used alone or in combination, accelerated the healing process of traumatic perforations of TMs.
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Ortiz, Laredo Núria. "Estudio comparativo del tratamiento quirúrgico de las perforaciones timpánicas con cartílago y con fascia en población pediátrica." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/377458.

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Introducción La cirugía de las perforaciones timpánicas es una técnica bien conocida por el otorrinolaringólogo. Actualmente el injerto más utilizado en su realización es la fascia de músculo temporal con un porcentaje de cierre elevado en población adulta y variable en población pediátrica. Cada vez es más utilizado en niños el injerto de cartílago, que es más resistente pudiendo aportar mayor tasa de éxito. Pero por su grosor, algunos autores lo han asociado con peores resultados auditivos. Actualmente no existe en la literatura un consenso con evidencia científica suficiente sobre qué tipo de injerto ofrece mejores resultados anatómicos y auditivos en niños. Hipótesis El empleo de cartílago como injerto para el cierre de las perforaciones timpánicas en niños es más eficaz que el injerto estándar de contrastada efectividad que es la fascia de músculo temporal, sin obtener peores resultados auditivos. Objetivos Comparar en niños el cierre de la perforación timpánica mediante cartílago en contraste con fascia de músculo temporal. Comprar en niños los cambios auditivos de la cirugía de las perforaciones timpánica sutilizando como injerto cartílago en contraste con fascia de temporal. Analizar en niños si el cierre de las perforaciones timpánicas se ve afectado por las siguientes variables: edad, sexo, estación del año en que se realiza la cirugía, oído operado, tamaño de la perforación, estado del oído contralateral al operado, localización de la perforación, cirugía previa, etiología de la perforación, abordaje y complicaciones. Material y métodos Se estudiaron 114 pacientes operados de perforación timpánica entre el 2003 y 2013 con un seguimiento mínimo de un año. Se compararon los resultados en cuanto a cierre de la perforación timpánica en el grupo operado con fascia y en el operado con cartílago. También se compararon los cambios auditivos en ambos grupos mediante la curva audiométrica más reciente y la posible influencia en los resultados de las variables edad, sexo, oído operado, etiología de la perforación, localización de la perforación, historia de cirugía previa, estado del oído contralateral, estación del año en el momento de la cirugía, abordaje y complicaciones. Resultados Se observa una relación estadísticamente significativa entre el cierre de las perforaciones timpánicas infantiles y el material de injerto utilizado, siendo mejores los resultados cuando éste es cartílago. También se observa relación con el tamaño de la perforación, con resultados más favorables en perforaciones menores al 50% y, con la presencia de complicaciones en el postoperatorio. Conclusiones En nuestra muestra el cartílago fue más efectivo para la reconstrucción de la membrana timpánica que la fascia de músculo temporal. Los cambios auditivos tras la cirugía de las perforaciones timpánicas fueron similares empleando cartílago y fascia. El tamaño de las perforaciones mayor o igual al 50% de las superficie timpánica y la presencia de complicaciones en el postoperatorio fueron factores de mal pronóstico en cuanto al cierre de las perforaciones timpánicas. La edad, el sexo, el oído afecto, la localización de la perforación, el antecedente de cirugía previa, el estado del oído contralateral, la estación del año en que se realiza la cirugía, el abordaje empleado y los valores auditivos preoperatorios no influyeron en el pronóstico de la cirugía.<br>Introduction Tympanic perforation surgery is well knows technique to otolaryngologist. Actually, temporalis muscle fascia is the most use graft material to close tympanic perforations. Fascia has better success in adult people than in children. Other materials as cartilage grafts had been proposed in children. But, some authors have doubts about hearing results using cartilage. Actually there’s no consensus about the ideal graft material for closure tympanic membrane perforations. Hypothesis Cartilage graft is better than fascia to close tympanic membrane perforations in children, with equivalent hearing results. Objectives Compare closure tympanic outcomes using cartilage and temporalis fascia in children. To compare hearing results using cartilage and temporalis fascia as a graft materials to close tympanic membrane perforations in children. Materials and methods A total of 114 children who underwent tympanic membrane perforation surgery from 2003 to 2013 were reviewed in this study. We compare closure tympanic membrane and hearing outcomes in the two groups, fascia and cartilage graft. Variables such as age, sex, side, site, size, aetiology, previous surgery, season, approach and postoperative complications were evaluated. Results The study showed a significant difference between closure of tympanic membrane perforations with cartilage and fascia, in favour of the cartilage grafting materials. It wasn’t significant differences in audiometric results between two grafts materials. Children with bigger tympanic membrane perforations and postoperative complication had poorer results. Conclusions Cartilage graft has better results than temporalis fascia to close tympanic perforations in our patients. Postoperative audiometric results are similar between the two groups, cartilage graft and fascia graft. Perforation larger than 50% and postoperative complications were negative prognostic factors for perforation closure. Age, sex, side, site, aetiology, previous surgery, season and approach were not prognostic factors.
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Hájek, Petr. "Výpočetní simulace přenosu zvukových signálů lidským uchem." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231143.

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The presented thesis concerns the biomechanics of hearing. The main aim of this work is the determination of so called corrections which allow for the comparison of synthetic audiograms and measured audiograms. With these corrections we attempt to overcome the discrepancy that exists between the computational modelling and audiological measurement. The discrepancy lies in a fact that the computational modelling usually simulates the sound coming from a free eld to the external auditory canal, while audiological measurement is realized by audiological headphones, whether the auditory system is healthy or injured. Then corrections adjust the computational model so that the obtained result is comparable to audiological measurement. In this work is also addressed the influence of stapes kinematics to the excitation of basilar membrane. The movement of stapes consists of piston-like movement and rocking movement. The computational simulation shows which movement is more signicant for the excitation of basilar membrane and how this effect can be used in otosurgery, in particular, for type IV of tympanoplasty.
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Books on the topic "Tympanic membrane perforations"

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Selvadurai, David, and Georgios Oikonomou. Tympanic membrane perforations. Edited by John Phillips and Sally Erskine. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834281.003.0005.

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This chapter discusses Macfadyen, Acuin, and Gamble’s paper on systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations including the design of the study, (including outcome measures, results, conclusions, and a critique).
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Book chapters on the topic "Tympanic membrane perforations"

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Chang, C. Y. Joseph. "Chronic Disorders of the Middle Ear and Mastoid (Tympanic Membrane Perforations and Cholesteatoma)." In Pediatric Otolaryngology for the Clinician. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-127-1_9.

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Dhillon, Ramindar S., and James W. Fairley. "Traumatic perforation of the tympanic membrane." In Multiple-choice Questions in Otolaryngology. Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10805-3_59.

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El Baba, Bassel, Carole Barake, Roger Moukarbel, Rosalyn Jurjus, Serkan Sertel, and Abdo Jurjus. "Stem Cells in the Management of Tympanic Membrane Perforation: An Update." In Stem Cells in Clinical Applications. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-33720-3_11.

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"Tympanic Membrane Perforations." In Atlas of Middle Ear Surgery, edited by Michel Gersdorff and Jean-Marc Gérard. Georg Thieme Verlag, 2011. http://dx.doi.org/10.1055/b-0034-67188.

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Soni, Nirmal, and Lokesh Bhama. "Traumatic Perforations of the Tympanic Membrane." In Clinical Cases in Otolaryngology. Jaypee Brothers Medical Publishers (P) Ltd., 2016. http://dx.doi.org/10.5005/jp/books/12833_10.

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Soni, Nirmal, and Lokesh Bhama. "Multiple Perforations of the Tympanic Membrane." In Clinical Cases in Otolaryngology. Jaypee Brothers Medical Publishers (P) Ltd., 2016. http://dx.doi.org/10.5005/jp/books/12833_15.

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Safran, Marc R., James Zachazewski, and David A. Stone. "Tympanic Membrane Perforation (Ruptured Eardrum)." In Instructions for Sports Medicine Patients. Elsevier, 2012. http://dx.doi.org/10.1016/b978-1-4160-5650-8.00410-6.

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"(c) Artificial Perforation of the Tympanic Membrane." In Offbeat Otolaryngology, edited by John D. C. Bennett and John Riddington Young. Georg Thieme Verlag, 2001. http://dx.doi.org/10.1055/b-0034-51842.

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Corbridge, Rogan, and Nicholas Steventon. "Common drugs used in ENT." In Oxford Handbook of ENT and Head and Neck Surgery. Oxford University Press, 2009. http://dx.doi.org/10.1093/med/9780199550791.003.21.

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Drugs used in the ear 348 Drugs used in the nose 349 Drugs used in the treatment of acid reflux 350 This group of drugs is widely used for the treatment of otitis externa. Otitis externa 2 drops tds for 10 days Presence of grommet or tympanic membrane perforation due to aminoglycoside ototoxicity in the inner ear. Risk thought to be low in the presence of active infection where the middle-ear mucosa is swollen and the antibiotic is unlikely to reach the inner ear via the round window...
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Roland, Peter S., Brandon B. Isaacson, and Joe W. Kutz. "Office Management of Tympanic Membrane Perforation and the Draining Ear." In Otologic Surgery. Elsevier, 2010. http://dx.doi.org/10.1016/b978-1-4160-4665-3.00008-1.

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Conference papers on the topic "Tympanic membrane perforations"

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HAKUBA, NOBUHIRO, and KIYOFUMI GYO. "CLOSING TYMPANIC MEMBRANE PERFORATIONS USING BASIC FIBROBLAST GROWTH FACTOR." In Proceedings of the 3rd Symposium. WORLD SCIENTIFIC, 2004. http://dx.doi.org/10.1142/9789812703019_0032.

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Jang Ho Kim, Joon-Ho Bae, Jong Hoon Chung, et al. "Development of Artificial Eardrum Patch to Repair Tympanic Membrane Perforations." In 2008 Providence, Rhode Island, June 29 - July 2, 2008. American Society of Agricultural and Biological Engineers, 2008. http://dx.doi.org/10.13031/2013.24820.

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von Unge, M., J. J. J. Dirckx, A. Rahman, and M. Hultcrantz. "ACUTE TYMPANIC MEMBRANE PERFORATIONS HEAL WITHOUT SIGNIFICANT LOSS OF STRENGTH." In Proceedings of the 4th International Symposium. WORLD SCIENTIFIC, 2007. http://dx.doi.org/10.1142/9789812708694_0019.

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Malic, M., and M. Gjuric. "Endoscopic transcanal myringoplasty for closing anterior perforations of the tympanic membrane." In Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711283.

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Man, Ruofei, Qihe Shan, Pengxiang Li, Yi Zuo, and Tieshan Li. "BLS-based Automatic Identification Framework for Tympanic Membrane Perforation." In 2021 International Conference on Security, Pattern Analysis, and Cybernetics(SPAC). IEEE, 2021. http://dx.doi.org/10.1109/spac53836.2021.9539912.

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Wang Shiqiang, Song Ruixiang, Yao Kun, and Wang Yu. "The research of noise induced tympanic membrane perforation in cotton textile industry." In 2008 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM). IEEE, 2008. http://dx.doi.org/10.1109/ieem.2008.4738139.

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Semmler, P., V. Vielsmeier, and P. Kwok. "Tympanic membrane perforation after intratympanic steroid injection with regard to local and systemic risk factors." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640601.

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Maeta, Manabu, Shinichiro Kawakami, Toshiaki Ogawara, and Yu Masuda. "Vibration analysis of the tympanic membrane with a ventilation tube and a perforation by holography." In Optics, Electro-Optics, and Laser Applications in Science and Engineering, edited by Halina Podbielska. SPIE, 1991. http://dx.doi.org/10.1117/12.44663.

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Jang, Kyoung-Je, Hoon Seonwoo, Myoungchul Lee, et al. "<i>Effects of Epidermal Growth Factor-Loaded Radially Oriented Nano-patterned Patch on Chronic Tympanic Membrane Perforation</i>." In 2017 Spokane, Washington July 16 - July 19, 2017. American Society of Agricultural and Biological Engineers, 2017. http://dx.doi.org/10.13031/aim.201701114.

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Reports on the topic "Tympanic membrane perforations"

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Welling, Bradley. Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada591173.

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