Academic literature on the topic 'Type-2 development'

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Journal articles on the topic "Type-2 development"

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Minal, C. Patel, and Singh S.K. "Obesity And Type 2 Diabetes Mellitus In Adolescents - A Review." International Journal of Basic and Applied Physiology 2, no. 1 (2013): 258–67. https://doi.org/10.5281/zenodo.4493768.

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: Obesity is highly prevalent in the modern world and it is associated with the development of a number of serious medical complications, like type 2 diabetes and cardiovascular diseases. Earlier, type 2 diabetes mellitus (T2DM) was regarded as a disease occurring in adults, while type 1 diabetes mellitus (T1DM) occurs in children and adolescents. This is true that T2DM is still more prevalent in adults, but there is increasing evidence that onset of type 2 diabetes in youth is frequently observed. Obesity increases the risk of T2DM by causing insulin resistance and directly or indirectly affe
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Jarvis, Blair, and Shelley Elkinson. "Agents in Development for Type 2 Diabetes." Drugs in R & D 2, no. 2 (1999): 95–99. http://dx.doi.org/10.2165/00126839-199902020-00002.

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Marott, Sarah C. W., Børge G. Nordestgaard, Anne Tybjærg-Hansen, and Marianne Benn. "Causal Associations in Type 2 Diabetes Development." Journal of Clinical Endocrinology & Metabolism 104, no. 4 (2018): 1313–24. http://dx.doi.org/10.1210/jc.2018-01648.

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Abstract Context Obesity, glucose, insulin resistance [homeostatic model assessment, version 2, for insulin resistance (HOMA2-IR)], and insulin secretion (HOMA2-β) have been associated with type 2 diabetes (T2D) observationally. However, the causal, genetic contribution of each parameter to this risk is largely unknown and important to study because observational data are prone to confounding but genetic, causal data are free of confounding and reverse causation. Objective We examined the causal, genetic contribution of body mass index (BMI), glucose level, C-peptide level, HOMA2-IR, and HOMA2
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Abdallah, Albajy Maitham, and Dan Florin Mihailescu. "Mechanisms of development of type 2 diabetes." International Journal of Biology Sciences 5, no. 1 (2023): 198–208. http://dx.doi.org/10.33545/26649926.2023.v5.i1c.187.

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Bhartia, Mithun, Abd A. Tahrani, and Anthony H. Barnett. "SGLT-2 Inhibitors in Development for Type 2 Diabetes Treatment." Review of Diabetic Studies 8, no. 3 (2011): 348–54. http://dx.doi.org/10.1900/rds.2011.8.348.

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Siva, Rami Reddy E., Parveen Kumar Sharma Dr., and Charanjeet Singh Dr. "Role of Homoeopathic Medicines in Type 2 Diabetes Mellitus." International Journal of Trend in Scientific Research and Development 3, no. 6 (2019): 127–33. https://doi.org/10.5281/zenodo.3587467.

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Diabetes Mellitus is metabolic disorder characterized by hyperglycemia in blood circulation mainly resulting from inadequate insulin secretion, insulin action or both and insulin resistance. Homoeopathic remedies have reported beneficial effect for treating in type 2 diabetes mellitus cases. Siva Rami Reddy E | Dr. Parveen Kumar Sharma | Dr. Charanjeet Singh "Role of Homoeopathic Medicines in Type 2 Diabetes Mellitus" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd
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Sayad, Maseera Fathima Arshad Shaik. "Incidence of Type 2 Respiratory Failure in Hypothyroidism." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 173–96. https://doi.org/10.5281/zenodo.14030809.

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The study investigates the incidence of Type 2 Respiratory Failure (T2RF) in hypothyroidism among 200 patients, exploring various parameters including age, gender, symptoms, exposure history, and comorbidities. T2RF, characterised by inadequate oxygenation of blood and retention of carbon dioxide, is a critical respiratory condition often associated with underlying medical disorders. Hypothyroidism, a common endocrine disorder resulting from decreased thyroid hormone production, can predispose individuals to respiratory complications, including T2RF, due to metabolic and respiratory muscle dys
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Lu, Da-Yong, Jin-Yu Che, Nagendra Sastry Yarla, et al. "Type 2 Diabetes Treatment and Drug Development Study." Open Diabetes Journal 8, no. 1 (2018): 22–33. http://dx.doi.org/10.2174/1876524601808010022.

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The causality and etio-pathologic risks for patients with Type 2 Diabetes (T2DM) are important areas in modern medicine. Disease complications are largely unpredictable in patients with T2DM. In the future, we welcome therapeutics of both cutting-edge and traditional for anti-diabetic treatments and management with higher efficiency and less cost. Expanding medical knowledge, behavior/life-style notification in healthcare, modern genetic/bioinformatics diagnostic promotion, clinical developments (Traditional Chinese Medicine and personalized medicine) and new drug developments - including cand
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MacKinnon, Neil J., Nicole R. Hartnell, Emily K. Black, et al. "Development of clinical indicators for type 2 diabetes." Canadian Pharmacists Journal 141, no. 2 (2008): 120–28. http://dx.doi.org/10.3821/1913-701x(2008)141[120:docift]2.0.co;2.

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Elizabeth, Miranda-Perez, Bentham Science Publisher Alarcon-Aguilar, Francisco J., Ortega-Camarillo Clara, Bentham Science Publisher Escobar-Villanueva та Maria Carmen. "Pancreatic β-Cells and Type 2 Diabetes Development". Current Diabetes Reviews 13, № 2 (2017): 108–21. http://dx.doi.org/10.2174/1573399812666151020101222.

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Dissertations / Theses on the topic "Type-2 development"

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Smit, Nicolaas Andrias Johannes. "School-Initiated Type-2 Activities in Continuous Professional Teacher Development." Diss., University of Pretoria, 2002. http://hdl.handle.net/2263/78496.

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Professional development is more than marking an attendance register at a workshop. Professional development is a reflective process of continuous self-development that should inform the very essence of any learning context. This dissertation builds on how teachers experience school-initiated type-2 teacher professional development in secondary public schools and how their experiences may contribute to the work in the field of teacher professional development and assessment. Although a number of studies have examined teachers’ comprehension of the Continuous Professional Development framework
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Sitaraman, Sneha. "Alveolar type 2 epithelial cells in lung development and disease." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1571062200291287.

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Zoso, Alice. "Human tissue-on-a-chip development for Type 2 Diabetes studies." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423774.

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Type 2 Diabetes (T2D) results from an insulin resistance condition that affects mainly adipose and skeletal muscle tissues by altering their glucose uptake and leading to major clinical complications. Moreover, it is known that these tissues interact each other with a negative cross-talk that worsen the pathology. Due to its clinical complexity, T2D would require patient-specific treatment. In this context it will be extremely helpful to have in vitro human tissue-based assays, able to provide biological responses representative of the in vivo patient-specific pathology. The aim of this PhD t
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Khaled, Walid T. "The role of STAT6 and type-2 cytokines in mammary gland development." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612880.

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Rogers, Catherine. "Development of a glycemic index checklist for individuals with type 2 diabetes." Connect to resource, 2009. http://hdl.handle.net/1811/37245.

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Aljwaid, Husam O. Dakhil. "Relationships between iron, oxidative stress, glycated proteins and the development of atherosclerosis in Type 2 diabetes." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/3222.

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Hyperglycaemia stimulates a variety of biochemical abnormalities. The area of particular interest in this study is the influence of non-enzymatic glycation of proteins on iron homeostasis, and particularly on non-transferrin-bound iron (NTBI) and its possible relation to atherogenesis in both Type 2 diabetic and obese non diabetic subjects. The link between non-enzymatic glycation of proteins and iron homeostasis, and development of macrovascular disease may be mechanistically different in Type 2 diabetic and obese non diabetic subjects due to a difference in the protein glycation pattern. Bec
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Zambon, Alessandro. "Development of microfluidic cell culture technology for the study of type 2 diabetes." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423422.

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Type 2 Diabetes Mellitus (T2DM) is a multi-factorial disease due to metabolic disorder with injuries in glucose homeostasis and body’s glucose uptake. The complexity of this disease led to the use of different classes of drugs acting with different mechanisms and targets and with effects that often change between patients. The number of people in the world with diagnosed T2DM is constantly increasing and consequently the cost for healthcare. Nowadays, a defined cure for T2DM patients has been not clearly identified. In the study of diabetes, animal models are one of the most popular syste
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Kikkas, Ingrid. "Development of immunoassays for diagnosis of type 1 diabetes." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114824.

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Le diabète de type 1 est une maladie auto-immune caractérisée par la destruction des cellules bêta des îlots de Langerhans du pancréas. Au cours de ce processus auto-immun, des auto-anticorps sont produits contre plusieurs antigènes des cellules bêta, par exemple l'insuline, l'acide glutamique décarboxylase (GAD65), la protéine tyrosine phosphatase (IA-2) et le transporteur de zinc (ZnT8). Au moins un auto-anticorps contre l'un de ces antigènes est présent dans> 95% des personnes atteintes de diabète de type 1 lors de la détection de l'hyperglycémie. Ces auto-anticorps peuvent servir de mar
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Chumachenko, Y., Вікторія Юріївна Гарбузова, Виктория Юрьевна Гарбузова, et al. "Association analysis between BGLAP rs1800247polymorphic variant and type 2 diabetes mellitus development among non-obese Ukrainians." Thesis, Sumy State University, 2020. https://essuir.sumdu.edu.ua/handle/123456789/77977.

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Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both genetic and environmental factors influence its development. Recent studies showed, that the bone tissue regulates systemic glucose metabolism through the secretion of undercarboxylated osteocalcin (uOCN) into the systemic circulation. It is known, that uOCN binds to the GPRC6A-receptor and, therefore, stimulates insulin expression and secretion in β-cells, as well as increases muscles, liver and adipose tissue sensitivity for insulin. Thus, the thymine to cytosine transition in OCN gene (BGLAP) pro
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Direk, Kenan. "The role of mitochondria in the development of insulin resistance and type 2 diabetes." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-mitochondria-in-the-development-of-insulin-resistance-and-type-2-diabetes(30f426ed-9221-473f-b177-acefda85acaa).html.

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This thesis explores three broad areas of interest in the pathophysiology of type 2 diabetes (T2D). The first part of the thesis examines the relative contributions of body fat measurements on T2D and related morbidities in a large cohort of twins. A proxy measure of visceral fat was constructed from anthropometric and dual-energy X-ray absorptiometry, its heritability was estimated at 58% using the classical twin model and its influence on morbidity was compared to total abdominal fat and the body mass index. The findings from this work show that intra-abdominal adiposity confers the greatest
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Books on the topic "Type-2 development"

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Ojkic, Davor. Development of a bovine adenovirus type 2-based gene delivery vector. Brock University, Dept. of Biological Sciences, 1997.

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Condon, Jennifer. 11[beta]-hydroxysteroid dehydrogenase type 2 and 1st role in fetal development. University of Birmingham, 1999.

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Mathur, Denise Newton. The development of educational tools for type 2 diabetes among the Cree First Nations Peoples of Attawapiskat, Ontario. Laurentian University, 2004.

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Hille, Reinhold Friedrich. Data abstraction and program development using Modula-2. Prentice Hall, 1988.

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Riley, David D. Data structures and software development in Java. Addison Wesley, 2003.

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Philipp, Jeannette. The transcription factor AP-2: Its expression and regulation in the cell types of the central nervous system and during the murine embryonal development. [s.n.], 1995.

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Zondervan Publishing House (Grand Rapids, Mich.), ed. NIV women's devotional Bible 2: New International version. Zondervan Pub. House, 1995.

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Poldnikov, Dmitriy. Comparative History of Foreign Law in 2 tt. INFRA-M Academic Publishing LLC., 2023. http://dx.doi.org/10.12737/2037407.

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The textbook presents an up-to-date view of the history of the law of foreign countries through the prism of identity, equivalence and diversity of legal traditions of the peoples of the East and West. The subject of study is the content of the leading legal traditions that give an idea of the range of historical types of law, the trends and conditions of their development from archaic forms to more complex ones, the possibilities of their renewal and reception when changing social patterns. Each legal tradition is considered according to a common analytical model: 1) historical context and be
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Croniger, Colleen, ed. Role of the Adipocyte in Development of Type 2 Diabetes. InTech, 2011. http://dx.doi.org/10.5772/1543.

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Sayer, Anthony P. North British Type 2 Bo-Bo Diesel-Electric Classes 21 And 29: Design, Development and Demise. Pen & Sword Books Limited, 2019.

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Book chapters on the topic "Type-2 development"

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Sanders, Thomas A. B. "Nutrition and Development: Type 2 Diabetes." In Nutrition and Development. John Wiley & Sons, Ltd,., 2013. http://dx.doi.org/10.1002/9781118782972.ch9.

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Abi Khalil, Charbel, and Shahrad Taheri. "Obesity and Type 2 Diabetes." In Molecular Mechanisms Underpinning the Development of Obesity. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-12766-8_12.

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Cinti, Saverio. "Development in Humans." In Obesity, Type 2 Diabetes and the Adipose Organ. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-40522-3_13.

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Dai, David Yun. "Type 2 Research: Differential Learning and Divergent Development." In Talent Development from the Perspective of Developmental Science. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-46205-4_5.

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Cinti, Saverio. "Murine Adipose Organ Development." In Obesity, Type 2 Diabetes and the Adipose Organ. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-40522-3_12.

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Misra, Parimal, and Ranjan Chakrabarti. "Type 2 Diabetes Mellitus: Marketed Drugs and Mechanisms." In Drug Discovery and Drug Development. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8002-4_7.

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Gaxiola, Fernando, Patricia Melin, and Fevrier Valdez. "Problem Statement and Development." In New Backpropagation Algorithm with Type-2 Fuzzy Weights for Neural Networks. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34087-6_3.

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Jafelice, Rosana Sueli da Motta, and Ana Maria Amarillo Bertone. "Interval Type-2 Fuzzy Sets in the Future: Scientific Projects for Development." In Biological Models via Interval Type-2 Fuzzy Sets. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64530-4_4.

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Miller, Simon, and Robert John. "An Interval Type-2 Fuzzy Multiple Echelon Supply Chain Model." In Research and Development in Intelligent Systems XXVI. Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-983-1_32.

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Kohara, M., and A. Nomoto. "Development of candidates for new type 2 and type 3 oral poliovirus recombinant vaccines." In Measles and Poliomyelitis. Springer Vienna, 1993. http://dx.doi.org/10.1007/978-3-7091-9278-8_29.

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Conference papers on the topic "Type-2 development"

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Nguyen, Minh Triet, Do Duc Tri, and Tien-Loc Le. "A Novel Adaptive Learning Systems for Type-2 Fuzzy Controller Based on Elman Neural Network." In 2024 7th International Conference on Green Technology and Sustainable Development (GTSD). IEEE, 2024. http://dx.doi.org/10.1109/gtsd62346.2024.10674968.

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Chiem, Trong-Hien, Van-Phong Vu, Do Duc Tri, and Tien-Loc Le. "Enhanced Control of Magnetic Levitation Systems Using Type-2 Fuzzy Elman Neural Network Cerebellar Model Articulation Controller." In 2024 7th International Conference on Green Technology and Sustainable Development (GTSD). IEEE, 2024. http://dx.doi.org/10.1109/gtsd62346.2024.10674998.

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Jaya, Eka Putra, and Sugito Sugito. "The Influence of Variations in the Thickness and Density of Hot Asphalt Pavement Layers on the Results of the Marshall Test Field Test of Laston AC-WC Mixture." In The 6th International Symposium on Infrastructure Development. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-v73n1g.

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One type of hot mix asphalt that is commonly in flexible pavement types is the Asphalt Concrete - Wearing Course (AC-WC), this type of hot mix asphalt is a type of wear layer pavement which means this type of pavement is applied to the surface layer.It is regulated in the General Specifications of Bina Marga Year 2018 Revision 2. The method used is to take samples in the field, then measure the thickness of the sample. After that, laboratory tests were carried out, namely density to get density and marshal test to get quality. Then a comparison was made between the test results and the JMF pla
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Muttaqin, Maraghi, Bustami Syam, Muhammad Yani, et al. "Fracture Initiation and Development of Road Marker Subjected to Impact Loading." In International Conference on Experimental and Computational Mechanic in Engineering 2023. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-jkjao0.

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To meet the needs of road marking design and manufacturing, we ensure that our products meet the ergonomic aspects. strong, comfortable and esthetical. Strength, of course, has something to do with the strength of the material and the structure stability of the road marking products. Plastic road marking material are not strong enough to withstand large impacts. Concrete road markers are also heavy and difficult to transport and install because they require a mobile crane. Based on this, temporary road markings are made from concrete foam composites, the mass of which is lighter than concrete
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Yamamoto, Tsutomu, and Takashi Futami. "Development of 2-Lamp Type HID Headlighting System." In International Congress & Exposition. SAE International, 1990. http://dx.doi.org/10.4271/900562.

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Koyama, T., T. Tsuji, H. Takano, et al. "Development of Multilayer Laue Lenses; (2) Circular Type." In THE 10TH INTERNATIONAL CONFERENCE ON X-RAY MICROSCOPY. AIP, 2011. http://dx.doi.org/10.1063/1.3625314.

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Krogvold, Lars. "2 Delaying the development of type 1 diabetes." In The 7th ASPED-ISPAD Diabetes Academy. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjpo-2024-asped.2.

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Watanabe, Kengo, Tsunetoshi Saito, Katsuki Suematsu, Ryo Nagase, and Masato Shiino. "Development of small MT type 2-multicore fiber connector." In Optical Fiber Communication Conference. OSA, 2014. http://dx.doi.org/10.1364/ofc.2014.w4d.6.

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McCarty, Kevin, Milos Manic, and Allan Gagnon. "A fuzzy framework with modeling language for type 1 and type 2 application development." In 2013 6th International Conference on Human System Interactions (HSI). IEEE, 2013. http://dx.doi.org/10.1109/hsi.2013.6577844.

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Haydim, Mustafa, Mustafa Tinkir, Mete Kalyoncu, and Umit Onen. "Network based type-2 fuzzy logic controller design for hydraulic system." In 2011 3rd International Conference on Computer Research and Development (ICCRD). IEEE, 2011. http://dx.doi.org/10.1109/iccrd.2011.5763868.

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Reports on the topic "Type-2 development"

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Federinko, John, Rusti L. Pool, William Z. Zeck, and Joseph D. Martin. Unit Type Code Development, Tailoring, and Optimization (UTC-DTO) Phase 2 Final Report. Defense Technical Information Center, 1997. http://dx.doi.org/10.21236/ada388557.

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Wang, Wei, and Yi Wu. Prediction models for diabetic retinopathy development in type 2 diabetes mellitus patients: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.3.0089.

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Padmanabhan, Radha K. Cloning and Expression of Genes for Dengue Virus Type-2 Encoded-Antigens for Rapid Diagnosis and Vaccine Development. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada241648.

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Techakumphu, Mongkol, Pranee Numchaisrika, Ampika Thongpakdee, Rattajuk Rungsiwiwat, Kamtorn Prugsananon, and Pramuan Virutamasen. Development of somatic cell nuclear transfer technique for biomedical and agricultural research (year II) : report. Chulalongkorn University, 2005. https://doi.org/10.58837/chula.res.2005.20.

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There are two objectives of the somatic nuclear transfer studies. The first objective was to evaluate the possibility to produce the inter-species cloned embryos from donor cells of different animals transfer to rabbit, pig or swamp buffalo oocytes. The second objective was to study the donor cell type can significantly affect the in vitro development of cloned rabbit embryos. The experiments are described in three chapters: Chapter 1: The in vitro development of inter-species cloned embryos, reconstructed using a rabbit recipient oocyte. Chapter 2: The in vitro development of inter-species cl
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Lin, Jane, Yi-Ling Cheng, Xi Cheng, Hui Shen, Ajay Pawar, and Karol Koziel. Development of Commercial Vehicle Emission Inventory and Analysis. Illinois Center for Transportation, 2024. http://dx.doi.org/10.36501/0197-9191/24-002.

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The objectives of this research are (1) to assemble and analyze commercial vehicle emission measurement data, (2) classify the effects of vehicle characteristics and traffic activities on commercial vehicle emissions, (3) estimate commercial vehicle emissions statewide in Illinois, and (4) identify truck emission-control strategies with a focus on truck electrification feasibility. The study found that vehicle type, make, age, odometer mileage, fuel type, engine brand (manufacturer), and engine built year are all important factors for truck emissions, and their effects are statistically signif
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Ori, Naomi, and Mark Estelle. Specific mediators of auxin activity during tomato leaf and fruit development. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597921.bard.

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The plant hormone auxin is involved in numerous developmental processes, including leaf and fruit development. The tomato (Solanumlycopersicum) gene ENTIRE (E) encodes an auxin-response inhibitor from the Aux/IAA family. While most loss-offunction mutations in Aux/IAA genes are similar to the wild type due to genetic redundancy, entire (e) mutants show specific effects on leaf and fruit development. e mutants have simple leaves, in contrast to the compound leaves of wild type tomatoes. In addition, e plants produce parthenocarpic fruits, in which fruit set occurs independently of fertilization
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Bonde, Ane, Tom Østergard-Dahl, David Moore, Mark D. Wenner, and Vanessa Ramirez. Community-Driven Rural Development: What Have We Learned? Inter-American Development Bank, 2003. http://dx.doi.org/10.18235/0008921.

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The purpose of this paper is to identify best practices in the design and implementation of community-driven rural development (CDRD) projects in Central America with special emphasis on Nicaragua. The methodology used in this study is two-fold. First, a literature review of the academic literature (chapter 2) and donor agency project documents and consultant reports (chapter 3) for Central America was conducted to understand key advances in the field and to derive a set of common findings. Second, field inter-views with key stakeholders and focus group interviews (about 30) were held in Nicar
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Gentry, William. “It’s not about me. It’s me & you.” How being dumped can help first-time managers. Center for Creative Leadership, 2016. http://dx.doi.org/10.35613/ccl.2016.1071.

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This paper presents research from the Center for Creative Leadership that found (1) the type of motivation first-time managers have for learning and development; and (2) the skill gaps first-time managers have in four specific leadership competencies: communication, influence, leading team achievement, and coaching and developing others.
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Beckett-Brown, C. E., A. M. McDonald, and M. B. McClenaghan. Discovering a porphyry deposit using tourmaline: a case study from Yukon. Natural Resources Canada/CMSS/Information Management, 2023. http://dx.doi.org/10.4095/331349.

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As the exploration for porphyry Cu-Au-Mo deposits has become increasingly challenging, the development of more effective techniques directed at detecting buried deposits has become critical. One methodology is to focus on key minerals, one of which is tourmaline, a robust, ubiquitous mineral in most mineralized porphyry systems. Overall, a combination of physical and chemical characteristics including 1) macro-color, 2) morphology, 3) inclusion populations, and 4) trace-element compositions are useful in discriminating between porphyry- versus non-porphyry-derived (or related) tourmaline in su
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Boisclair, Yves R., and Arieh Gertler. Development and Use of Leptin Receptor Antagonists to Increase Appetite and Adaptive Metabolism in Ruminants. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697120.bard.

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Abstract:
Objectives The original project had 2 major objectives: (1) To determine the effects of centrally administered leptin antagonist on appetite and adaptive metabolism in the sheep; (2) To develop and prepare second-generation leptin antagonists combining high binding affinity and prolonged in vivo half-life. Background Periods of suboptimal nutrition or exaggerated metabolic activity demands lead to a state of chronic energy insufficiency. Ruminants remain productive for a surprisingly long period of time under these circumstances by evoking adaptations sparing available energy and nutrients. Th
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