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Journal articles on the topic 'Type 2 Diabetes Mellitus (T2DM)". "Mean Platelet Volume (MPV)"'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Hussain, Ali Rangwala, and Sankala Manoj. "Association of Mean Platelet Volume with That of the Diabetic Status of Patients with T2DM." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 1520–26. https://doi.org/10.5281/zenodo.11239122.

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<strong>Introduction: </strong>Diabetes mellitus (DM) affects about 10% of the world’s population and is developing quickly. Chronic hyperglycemia in DM affects endothelial function and arteries. Controlling blood sugar affects microvascular (nephropathy, retinopathy) and macrovascular (heart disease). MPV might be a biomarker for DM-related vascular issues. Cardiovascular events, excluding DM, had elevated MPV. <strong>Aims and Objectives:</strong> This study evaluates the correlation between “Mean Platelet Volume (MPV)” and the state of “Type 2 Diabetes

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Nakhro, Nuneno, Poonam Khambra, Sonam Sharma, and T. Banikanta Singha. "Metabolic consequences on platelet parameters: Mean platelet volume and platelet distribution width in type 2 diabetes mellitus." Asian Journal of Medical Sciences 15, no. 10 (2024): 45–50. https://doi.org/10.71152/ajms.v15i10.4154.

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Background: Diabetes mellitus encompasses metabolic disorders marked by chronic hyperglycemia, leading to various complications. It is considered a prothrombotic state associated with increased platelet reactivity. Parameters such as mean platelet volume (MPV) and platelet distribution width (PDW), which are indicative of platelet size, enzymatic activity, and prothrombotic risk, can be readily assessed during routine hematological analysis, facilitating early detection of this prothrombotic state. Aims and Objectives: The study aimed to investigate the varied alterations in platelet parameter

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Nakhro, Nuneno, Poonam Khambra, Sonam Sharma, and T. Banikanta Singha. "Metabolic consequences on platelet parameters: Mean platelet volume and platelet distribution width in type 2 diabetes mellitus." Asian Journal of Medical Sciences 15, no. 10 (2024): 45–50. http://dx.doi.org/10.3126/ajms.v15i10.67644.

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Background: Diabetes mellitus encompasses metabolic disorders marked by chronic hyperglycemia, leading to various complications. It is considered a prothrombotic state associated with increased platelet reactivity. Parameters such as mean platelet volume (MPV) and platelet distribution width (PDW), which are indicative of platelet size, enzymatic activity, and prothrombotic risk, can be readily assessed during routine hematological analysis, facilitating early detection of this prothrombotic state. Aims and Objectives: The study aimed to investigate the varied alterations in platelet parameter

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AKHANLI, Pınar, Sema HEPŞEN, Muhammed KİZİLGUL, et al. "The impact of SGLT2-inhibitor therapy on platelet function in type 2 diabetes mellitus." Journal of Health Sciences and Medicine 6, no. 1 (2023): 140–44. http://dx.doi.org/10.32322/jhsm.1202548.

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Aim: We consider mean platelet volume (MPV), an a pointer of platelet activity related to type 2 diabetes mellitus (T2DM) and vascular complications, in patients using Sodium-Glucose Co-Transporter 2 inhibitors (SGLT2i). Therefore, we aimed to evaluate the MPV change after SGLT2i use in diabetic patients. Materials and Methods: Hemogram parameters such as hemoglobin, hematocrit, and MPV in the 0th and 24th weeks of 102 patients with T2DM that received SGLT2i treatment added to their existing medications and of the control group in which participants are compatible in terms of age and gen

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Paul, Arijit, Soumyadip Das, Koushik Bose, and Rupam Karmakar. "Platelet Indices: Predicting Retinopathy in Patients with Type 2 Diabetes Mellitus." Medical Journal of Dr. D.Y. Patil Vidyapeeth 17, no. 6 (2024): 1231–35. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_968_23.

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Background: Diabetes mellitus (T2DM) is a metabolic disorder, characterized by insulin resistance and varying degrees of hyperglycemia, leading to several macrovascular and microvascular complications. In recent years, altered platelet morphology and dysfunctions are reported in patients with T2DM. Platelet indices, namely plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW), can predict altered platelet morphology and dysfunction which leads to microvascular complications, such as retinopathy. Aims: This study was aimed at comparing platelet indices in individ

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Yilmaz, Tolga, and Ahu Yilmaz. "Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus." Journal of Ophthalmology 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/9213623.

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Purpose. To investigate whether platelet morphology or function is altered in patients with diabetic retinopathy (DR).Methods. This prospective study enrolled 85 healthy controls (HCs) (group 1) and 262 patients with Type 2 diabetes mellitus (T2DM). Patients were subclassified into three groups according to ocular findings: no DR (group 2;n=88); nonproliferative DR (group 3;n=88), and proliferative DR (group 4;n=86). Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT) values, and platelet count were measured in the studied groups.

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Ashraf, Jahanzaib, Uffaq Farrukh, Amanullah Bhalli, and Uneeba Syed. "Comparison of Mean Platelet Volume in Patients with and Without Diabetes Mellitus at a Tertiary Care Hospital." Biological and Clinical Sciences Research Journal 6, no. 3 (2025): 31–34. https://doi.org/10.54112/bcsrj.v6i3.1607.

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Mean Platelet Volume (MPV) is a platelet activation marker linked to various cardiovascular diseases. Type 2 Diabetes Mellitus (T2DM) is known to increase the risk of thrombosis, and changes in platelet characteristics, including MPV, may contribute to this risk. Objective: This study aimed to compare the MPV in patients with and without T2DM at a tertiary care hospital. Methods: This randomized controlled trial was conducted at Akhtar Saeed Trust Hospital, Lahore, with 98 participants (49 diabetic and 49 non-diabetic) from 18 October 2024 Till 17 January 2025. Data were collected through non-

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Gamage, V. N. U., M. G. M. Mohotti, and K. A. C. Wickramaratne. "Differences in platelet indices between type-2 diabetes mellitus patients with and without microvascular complications at Teaching Hospital, Karapitiya." Sri Lanka Journal of Haematology 15, no. 1 (2024): 19–26. http://dx.doi.org/10.4038/tsljh.v15i1.11.

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Type-2 Diabetes Mellitus (T2DM) is associated with a greater amount of morbidity and mortality due to microvascular and macrovascular complications. Involvement of platelets in vascular complications of diabetes is well known and changes in platelet indices have been identified as predictors of these vascular complications. This study was carried out to determine the changes in platelet indices in patients with T2DM. This was a comparative cross sectional study conducted at Teaching Hospital, Karapitiya. Study subjects included T2DM patients with microvascular complications as study group and

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V, Soumya, Sukesh Sukesh, Rubina M P, Mohammed Safeer T K, Riyas Basheer K B, and Nayana K Babu. "Platelet Metrics In Type 2 Diabetes: A Practical Tool For Assessing Vascular Complications." Journal of Neonatal Surgery 14, no. 28S (2025): 1014–19. https://doi.org/10.63682/jns.v14i28s.7332.

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Background: Chronic metabolic disorder Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, which is associated with a range of complications, particularly vascular complications that significantly contribute to morbidity and mortality among patients. The ability to predict these complications early is crucial for preventive strategies and patient management. This study provides an overview of the practicality of platelet parameters for predicting vascular complications in type 2 diabetes patients, highlighting their importance in diabetes management and the potential benefits of

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Dipeeka, D. Patel, Chunilal Koitiya Nayan, Gajjar Dipti, and Gulabbhai Keyurkumar. "The Study of Relationship Between Glycemic Control and Platelet Activity in Type 2 Diabetes Mellitus Patients of Tertiary Care Hospital at Rajpipla, Gujarat." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 166–69. https://doi.org/10.5281/zenodo.12717182.

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<strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder characterized by chronic hyperglycemia. Glycemic control in T2DM patients is crucial for minimizing complications, one of which is altered platelet activity, contributing to increased cardiovascular risk. This study aims to investigate the relationship between glycemic control and platelet activity in T2DM patients over a six-month period. <strong>Materials and Methods: </strong>This prospective study was conducted at GMERS Medical College, Rajpipla, Gujarat, involving 110 T2DM patient

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Shehri, Zafer Saad Al. "The relationship between some biochemical and hematological changes in type 2 diabetes mellitus." Biomedical Research and Therapy 4, no. 11 (2017): 1760. http://dx.doi.org/10.15419/bmrat.v4i11.382.

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Introduction: The aim of this study was to investigate various biochemical and hematological parameters in patients with type 2 diabetes mellitus (T2DM) and compare those with non-diabetic subjects (control group). Subjects: The study was conducted on 405 subjects (ages ranging from 26-65 years old; sex matched) who were classified into two groups: diabetic (n=205 subjects; males-105, females-100) and non-diabetic subjects (n=200; males-100, females-100). The study was carried out during the period of November 2016 to April 2017 in the Department of Clinical Laboratory Sciences at the Co

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Taggara, Nelly Tolla. "ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (2019): 102. http://dx.doi.org/10.24293/ijcpml.v26i1.1411.

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ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION Nelly1, Suci Aprianti2 ,Darmawaty ER31Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo hospital, Makassar2Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University3Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University /Dr. Wahidin Sudirohusodo Hospital, Makassar ABSTRACT Introduction :Type 2 Diabetes Mellitus(T2DM) is an endocrin disease that is marked by hyperglycemic condition

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Ogbuabor, Alphonsus Ogbonna, Loius Nkiruka Onyia, and Edwin Obiora Ohotu. "Evidence for Platelet Activation According To Some Platelet Indices in a Cohort of Type 2 Diabetic Mellitus Patients." Saudi Journal of Biomedical Research 7, no. 11 (2022): 299–303. http://dx.doi.org/10.36348/sjbr.2022.v07i11.004.

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Diabetes mellitus has over the years become a public health issue. It is a complex disease which is characterized by chronic hyperglycemia. The present study was designed to determine some platelet indices in Type 2 Diabetic Mellitus (T2DM) patients compared to non-diabetic controls. A total of 240 subjects comprising 120 T2DM (60 males and 60 females) aged 20-55 years and 120 apparently healthy age and gender-matched controls were recruited for the study. Blood samples (5.0ml) were collected from each subject for the analysis of the parameters using Mindray 530 BC automated analyzer, Mindray,

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Fajkić, Almir, Rijad Jahić, Orhan Lepara, et al. "Širina distribucije eritrocita i trombocitni indeksi kao inflamatorni parametri kod pacijenata sa šećernom bolesti tipa 2 i disfunkcijom bubrega." Medicina Fluminensis 60, no. 2 (2024): 184–92. http://dx.doi.org/10.21860/medflum2024_316191.

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Aim: To assess Red blood cell Distribution Width (RDW) and platelet indices values in patients with type 2 diabetes mellitus (T2DM) and to verify its association with kidney dysfunction (KD). Patients and Methods: A cross-sectional study included 149 T2DM subjects divided into two groups with (T2DM – KD; n=52) and without (T2DM-nKD; n=97) presence of kidney dysfunction and 30 healthy subjects. White Blood Cells (WBC) count, C-reactive protein (CRP), fibrinogen, RDW, platelet indices, urea, and creatinine, were measured in all participants. Kidney function was evaluated by the estimated glomeru

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Spectre, Galia, Lisa Arnetz, Claes-Göran Östenson, Kerstin Brismar, Nailin Li, and Paul Hjemdahl. "Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications." Thrombosis and Haemostasis 106, no. 09 (2011): 491–99. http://dx.doi.org/10.1160/th11-04-0216.

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SummaryThe efficacy of low-dose aspirin in type 2 diabetes mellitus (T2DM) has been questioned. We tested if twice daily dosing of aspirin would be more effective in T2DM, possibly due to increased platelet turnover. A randomised cross-over study compared 75 mg aspirin OD, 75 mg BID and 320 mg OD (≥2 week treatment periods) in 25 patients with T2DM and micro- or macrovascular complications. Platelet responses were examined by impedance aggregometry (WBA) and the IMPACT-R aspirin test in whole blood, light transmittance aggregometry in plateletrich plasma (LTA), and urinary 11-dehydro-thromboxa

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Regassa, Dereje Abebe, Gebeyaw Arega Berihun, Bisrat Fikadu Habtu, Woyesa Beyene Haile, Rahel Shumi Nagaash, and Girum Tesfaye Kiya. "Platelet indices as predictors of poor glucoregulation in type 2 diabetes mellitus adults at Bishoftu General Hospital, Ethiopia." World Journal of Diabetes 15, no. 9 (2024): 1889–902. http://dx.doi.org/10.4239/wjd.v15.i9.1889.

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BACKGROUND Diabetes is a chronic metabolic syndrome that has become a global public health problem with significant morbidity and mortality. It is a pro-inflammatory and pro-thrombotic condition characterized by increased platelet activation and alterations in platelet indices. However, the use of platelet indices as predictors of poor glucoregulation has not been fully evaluated in this context, and evidence for their role as predictors of poor glycemic status in diabetic patients is limited. AIM To evaluate platelet indices and determine their prognostic significance in relation to inadequat

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Dasarathan, Ramesh, Rajendran Velayudham, Haridoss Krishnan, and Senthilkumar S. "The vitamin B12 levels in type 2 diabetes mellitus patients on metformin and not on metformin." International Journal of Advances in Medicine 8, no. 2 (2021): 165. http://dx.doi.org/10.18203/2349-3933.ijam20210270.

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Background: Type 2 diabetes mellitus (T2DM) is one of the major global public health concerns, metformin is one of the most widely used drugs and considered as first-line therapy for management of T2DM. Vitamin B12 malabsorption is observed in patients on metformin therapy leading to biochemical and clinical vitamin B12 deficiency. The aim of the current study was to assess the relationship between metformin therapy and development of vitamin B12 deficiency.Methods: Current observational cross sectional study was conducted at Madras medical college and Rajiv Gandhi Government general hospital.

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Kodiatte, Thomas Alex, Udaya Kumar Manikyam, Suraksha Bellur Rao, et al. "Mean Platelet Volume in Type 2 Diabetes Mellitus." Journal of Laboratory Physicians 4, no. 01 (2012): 005–9. http://dx.doi.org/10.4103/0974-2727.98662.

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ABSTRACT Context: diabetes mellitus is a global pandemic. The increased platelet activity may play a role in the development of vascular complications of this metabolic disorder. The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Larger platelets are younger and exhibit more activity. Aims: to determine the MPV in diabetics compared to nondiabetics, to see if there is a difference in MPV between diabetics with and without vascular complications, and to determine the correlation of MPV with fasting blood glucose, glycosylated hemoglobin (HbA1c), body-m

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Thakur, Aman, Purbesh Adhikari, Mona Dahal, Paricha Upadhyaya, Smriti Karki, and Anju Pradhan. "Role of mean platelet volume in patients with type 2 diabetes mellitus." Indian Journal of Pathology and Oncology 10, no. 2 (2023): 126–31. http://dx.doi.org/10.18231/j.ijpo.2023.028.

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In type 2 diabetes mellitus, increased platelet activity is crucial for the emergence of vascular complications. Mean platelet volume (MPV), an indicator of enhanced platelet activity, may be helpful in identifying the thromboembolic events that lead to these vascular complications. This study aims to assess MPV in Type 2 Diabetes patients and investigate the relationship between MPV and glycaemic and diabetic complications. : A comparative cross-sectional study was carried out on 266 subjects (133 diabetic patients and 133 nondiabetic controls) at B.P Koirala Institute of Health Sciences for

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Nasution, Malayana Rahmita, Adi Koesoema Aman, and Dharma Lindarto. "RERATA VOLUME TROMBOSIT DAN AGGREGASI TROMBOSIT DI DIABETES MELITUS TIPE 2 (Mean Platelet Volume and Platelet Aggregation in Diabetes Mellitus Type 2)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 3 (2018): 293. http://dx.doi.org/10.24293/ijcpml.v21i3.1283.

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Diabetes mellitus patients often have hypercoagulable blood, as evidenced by the increased coagulation, impaired fibrinolysis,endothelial dysfunction and platelet hyperactivity. Hyperactive platelet is the major determinant of pro thrombotic state in DM. Byassessing the MPV and platelet aggregation, which is a marker of platelet activity, in patients with type 2 DM, it is expected to help theprediction of acute events. This research is aimed to know the differences of MPV and the aggregation of platelet between poor glycemiccontrol as well as good the control group in type 2 DM patients. This

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Swetaba, C. Solanki, Agrawal Veeha, and L. Parmar Tejendrasinh. "The Significance of Mean Platelet Volume in Type 2 Diabetes Patients." International Journal of Toxicological and Pharmacological Research 14, no. 11 (2024): 96–101. https://doi.org/10.5281/zenodo.14562615.

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<strong>Background and Aim: </strong>Diabetes mellitus has emerged as a significant global health crisis. Heightened platelet activity could contribute to the emergence of vascular complications associated with this metabolic disorder. The mean platelet volume (MPV) serves as a crucial marker for assessing the average size and functionality of platelets. Research indicates that larger platelets are typically younger and demonstrate increased activity levels. This study focused on comparing mean platelet volume (MPV) in patients with Type 2 Diabetes against non-diabetic controls. It also e

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Swetaba, C. Solanki, Agrawal Veeha, and L. Parmar Tejendrasinh. "The Significance of Mean Platelet Volume in Type 2 Diabetes Patients." International Journal of Toxicological and Pharmacological Research 14, no. 11 (2024): 164–69. https://doi.org/10.5281/zenodo.14588853.

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<strong>Background and Aim: </strong>Diabetes mellitus has emerged as a significant global health crisis. Heightened platelet activity could contribute to the emergence of vascular complications associated with this metabolic disorder. The mean platelet volume (MPV) serves as a crucial marker for assessing the average size and functionality of platelets. Research indicates that larger platelets are typically younger and demonstrate increased activity levels. This study focused on comparing mean platelet volume (MPV) in patients with Type 2 Diabetes against non-diabetic controls. It also e

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Dervisevic, Emina, Anes Jogunčić, Muamer Dervišević, et al. "Increased mean platelet volume is associated with acute myocardial infarction in patients with diabetes mellitus type 2." International Journal of Research in Medical Sciences 10, no. 7 (2022): 1426. http://dx.doi.org/10.18203/2320-6012.ijrms20221784.

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Background: The correlation between diabetes mellitus and acute myocardial infarction is greater every day. The mean platelet volume (MPV), which is the determinant of platelet function, is an independent risk factor for the cardiovascular disease. The aim of the study was to investigate the effect of each disease (hypothyroidism, hypertension, myocardial infarction) individually and combined on MPV in diabetic patients.Methods: The cross-sectional study included 102 patients who suffer from diabetes mellitus type 2 (DMT2), of both sexes (46 females, 56 males), with the average age of 58.91 (S

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Bhanukumar, M., Prasanna KH Ramaswamy, Naveen K. Peddi, and Vineetha B. Menon. "Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus." Journal of Postgraduate Medicine, Education and Research 50, no. 3 (2016): 127–31. http://dx.doi.org/10.5005/jp-journals-10028-1204.

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ABSTRACT Aims The objective of the study was to determine the mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with type 2 diabetes mellitus (type 2 DM) compared to subjects without type 2 DM and their correlation with fasting blood glucose, glycosylated hemoglobin (HbA1c), and duration of type 2 DM respectively. Materials and methods A prospective analytical case—control study was conducted involving 50 subjects with type 2 DM and 50 subjects without type 2 DM. The mean and standard deviation were estimated for both the groups separately and independent Student's “

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Nasution, Malayana Rahmita, Adi Koesoema Aman, and Dharma Lindarto. "RERATA VOLUME TROMBOSIT DAN AGGREGASI TROMBOSIT DI DIABETES MELITUS TIPE 2." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 3 (2016): 293. http://dx.doi.org/10.24293/ijcpml.v21i3.743.

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Diabetes mellitus patients often have hypercoagulable blood, as evidenced by the increased coagulation, impaired fibrinolysis, endothelial dysfunction and platelet hyperactivity. Hyperactive platelet is the major determinant of pro thrombotic state in DM. By assessing the MPV and platelet aggregation, which is a marker of platelet activity, in patients with type 2 DM, it is expected to help the prediction of acute events. This research is aimed to know the differences of MPV and the aggregation of platelet between poor glycemic control as well as good the control group in type 2 DM patients. T

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Vasudhevan, Ajantha Swamy, Dhivya Mohan Sumathi, Ashwath Kumar Chinnaraju Selvakumar, and Rajabalaji Rajabalaji. "A Comparative Study of Mean Platelet Volume in Diabetic Population With and Without Vascular Complication." Indonesian Journal of Medical Laboratory Science and Technology 5, no. 1 (2023): 42–52. http://dx.doi.org/10.33086/ijmlst.v5i1.3465.

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Diabetes mellitus leads to long-term complications involving multiple organs and systems of the human body. Among the list of complications, a relatively vascular complication increases the morbidity of the condition. Patients with diabetes mellitus are influenced by various factors like hyperglycaemic state, insulin resistance, oxidative stress, and metabolic condition like obesity, and all the mentioned conditions also present with platelet hyperactivity. Mean platelet volume (MPV) can be used as one of the laboratory parameters to know the function and activation of the platelets, which ref

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Nagiya, Shivendra, Reena Singh, and Anshul Sharma. "ROLE OF MPV IN COMPLICATION OF DIABETES MELLITUS 2." International Journal of Advanced Research 10, no. 08 (2022): 234–40. http://dx.doi.org/10.21474/ijar01/15171.

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Diabetes mellitus (DM) is a global health problem with increased risk of vascular disease. Platelets may contribute to the development of vascular complications in subjects with diabetes. Larger platelets are more reactive than smaller ones therefore, mean platelet volume (MPV) can be used as a marker for platelet activity. Aim and Objectives: To determine the role of MPV in severity and complications of DM2 as compared to non diabetic patients and to determine the effect of glycemic control and duration of diabetes on platelet parameters. This is a cross-sectional prospective study to evaluat

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Saktiningsih, Hari, Mastuti Widi Lestari, and Warih Anjari Dyah Kusumaning Ayu. "Hubungan Nilai MPV (Mean Platelet Volume) dengan Kadar Glukosa Darah pada Penderita Diabetes Melitus Tipe 2." Jurnal Surya Medika 8, no. 2 (2022): 281–85. http://dx.doi.org/10.33084/jsm.v8i2.3589.

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Diabetes mellitus (DM) type 2 is a group of disorders characterized by elevated blood glucose levels (hyperglycemia). This condition is caused by a decrease in the body's ability to respond to insulin (insulin resistance) or due to a decrease in the amount of insulin by the pancreas. Mean platelet volume (MPV) indicates platelets' mean size and activity. In diabetics, a high MPV value can predict an increased risk of thrombosis and chronic complications. This study aimed to determine the relationship between MPV values and blood glucose in Type 2 DM. The type of this research was observational

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Sinha, Anirban, Aparajita Samaddar, and Manas Talukdar. "Platelet indices in controlled and uncontrolled type 2 diabetes mellitus: A cross sectional study." Panacea Journal of Medical Sciences 12, no. 3 (2022): 533–37. http://dx.doi.org/10.18231/j.pjms.2022.101.

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Diabetes is an emerging health problem across the world. Underlying prothrombotic state leads to cardiovascular complications in diabetics especially those with poor glycemic control. Though multiple mechanisms are responsible, platelet activation plays a major role in the pathogenesis of prothrobotic state. Platelet activation causes increase in their size which is represented by Mean Platelet Volume (MPV) whereas variation in their size associated with release reaction is reflected by Platelet Distribution Width (PDW). So MPV and PDW together may help to detect emergence of prothrombotic sta

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Astuti, Dian W., Sony Wibisono, Arifoel Hajat, and Sidarti Soehita. "CORRELATIONS BETWEEN MEAN PLATELET VOLUME AND IMMATURE PLATELET FRACTION TO HEMOGLOBIN A1C IN PATIENTS WITH TYPE 2 DIABETES MELLITUS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 24, no. 1 (2018): 6. http://dx.doi.org/10.24293/ijcpml.v24i1.1148.

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Pasien diabetes melitus tipe 2 berkebahayaan mengalami komplikasi makro dan mikrovaskuler, yang dipengaruhi oleh kendaliglikemik. Reaktivitas trombosit berperan pada timbulnya komplikasi ini, terutama komplikasi kardiovaskuler. Tujuan penelitian iniadalah membandingkan MPV dan IPF di kendali glikemik baik dan buruk dan menentukan adanya kenasaban MPV dan IPF terhadapHbA1c. Penelitian bersifat analitik observasional dengan rancang bangun potong lintang. Sampel darah EDTA dari 43 orang pasienDM tipe 2, dikumpulkan selama Januari-Februari 2016. HbA1c diperiksa dengan Dimension RxL, sedangkan MPV

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Umesh, Kumar, and Deepak Rajkumar. "Study of Mean Platelet Volume in Type 2 Diabetes Mellitus with Special Reference to MicrovascularComplications." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 830–34. https://doi.org/10.5281/zenodo.12738078.

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<strong>Background and Objectives: </strong><strong> </strong>According to International Diabetic Federation 2014 Atlas, India has highest diabetic cases when compared to other south Asian countries, with 66.8 million.80% of patients with diabetes mellitus die a thrombotic death. The increased platelet activity may play role in the development of vascular complications of diabetes. MPV is an indicator of the average size and activity of platelets. The study aims to compare the MPV of diabetic patients and non-diabetics, to see if difference in MPV in diabetic patients with and withou

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Li, Yiqing, Songmei Yin, Danian Nie, et al. "The Variation of Platelet Function in Gestational Diabetes Mellitus." Blood 108, no. 11 (2006): 3957. http://dx.doi.org/10.1182/blood.v108.11.3957.3957.

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Abstract Gestational diabetes mellitus (GDM) was as glucose intolerance of different severity that onset or first recognition during the current pregnancy. GDM was a special complication of pregency and the most common cause of fetal and maternal mortality and morbidity. The etiology of this disease is not clear. Increased platelet function was common in normal pregnancy or type 2 diabetes mellitus (DM) patients in the last decade. However, when pregnancy plus type 2 DM, that is, the GDM, was the platelet function still changed? In the current study, we tested blood platelet function including

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Persy, Haobijam, Ratan Konjengbam, Salam Ranabir, and Babina Sorokhaibam. "Association of platelet parameters with chronic complications in type 2 diabetes mellitus." Indian Journal of Pathology and Oncology 11, no. 3 (2024): 264–69. http://dx.doi.org/10.18231/j.ijpo.2024.058.

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To determine the association of platelet parameters with chronic complications in patients with type 2 diabetes mellitus.Platelets play an important role in the integrity of normal homeostasis. Altered platelet morphology and platelet hyperactivity is associated with an increased prothrombotic state. In diabetes mellitus, there is increased platelet activity which eventually play a role in the development of vascular complications which are responsible for its morbidity and mortality. A hospital based prospective cohort study was performed to study the level of platelet parameters in patients

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Kamlesh, Kumar Meena, Solanki Arun, Lal Jat Shankar, Samaria Anil, and Monika. "Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus and Its Correlation with Albuminuria and HbA1c Levels." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 1578–81. https://doi.org/10.5281/zenodo.11528678.

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Diabetes mellitus is a heterogeneous group of disorders that have in common the metabolic defect of hyperglycemia. The mechanisms by which this hyperglycaemia is produced vary, and they may be acquired, genetic or environmental. This ultimately results in impaired pancreatic insulin secretion, impaired peripheral utilization of glucose, and enhanced hepatic glucose production. The prevalence of diabetes according to the WHO criteria was 5.6% among the urban areas and 2.7% among rural areas. The mean platelet volume is one of the hematological parameters used to assess platelet function and act

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Abel-Rahman, Sayed M., Essam S. Badawy, Ahmad A. Amer, and Dalal Fekry. "Mean platelet volume as a risk factor in pregnant diabetic women." Egyptian Journal of Internal Medicine 24, no. 2 (2012): 32–36. http://dx.doi.org/10.7123/01.ejim.0000419581.67334.75.

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Abstract Background Diabetes is an established risk factor for cardiovascular disease (CVD); therefore, the subset of women with gestational diabetes mellitus (GDM) who develop type 2 diabetes mellitus is at an increased risk for developing CVD in the future. Objectives To assess the platelet count and mean platelet volume (MPV) of pregnant women with GDM and gestational impaired glucose tolerance (GIGT) to determine whether GDM and GIGT are risk factors for future development of CVD. Patients and methods A 50 g oral glucose load (OGL) was administered to all participants (400 pregnant women),

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Sangapur, Shivakanth M., Darshan R. S., Sharanabasappa, and Baldev Meena. "Platelet indices and their correlation with HbA1c and association with microvascular complications in type-2 diabetes mellitus." International Journal of Research in Medical Sciences 11, no. 5 (2023): 1594–99. http://dx.doi.org/10.18203/2320-6012.ijrms20231321.

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Background: Depending on the aetiology of the DM, factors contributing to hyperglycaemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. Mean platelet volume (MPV) and platelet distribution width (PDW) are important, simple, effortless, and cost-effective tools measured by hematology analyser which assess the volume and function of platelets. Analysing the platelet parameters can act as an alarm for progression of complications of DM. Hence, we studied the platelet parameters in diabetic patients with good and poor glycaemic control and their

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Jyoti, Kumari, and Kumar Amit. "Assessment of the Role of Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus: An Observational Study." International Journal of Current Pharmaceutical Review and Research 15, no. 12 (2023): 156–60. https://doi.org/10.5281/zenodo.11371938.

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Aim: The aim of the present study was to determine the correlation of MPV with fasting blood glucose,glycosylated hemoglobin (HbA1c), body-mass index, and duration of diabetes in the diabetic patients.Material & Methods: This was a cross-sectional study carried out in Department of Pathology, including 100patients who were already diagnosed to have Type 2 DM and 100 nondiabetic subjects without known coronaryartery disease in between the duration of 12 months.Results: There were more male as compared to females in both groups. MPV was significantly raised in thediabetic population in compa

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Syed Farhan Uddin, Shabnam Rani, Nudrat Zeba, Gordhan, Zaheer Hussain, and Mohammad Khalid Nizaman. "The Physiological Association Between Mean Platelet Volume and Diabetes Mellitus Type 2: Correlation Between HbA1c Score and MPV Index." Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University 20, SUPPL-1 (2024): 459–63. http://dx.doi.org/10.48036/apims.v20isuppl-1.1109.

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Objective: To evaluate difference in mean platelet volume between non-diabetics and diabetics individual and to find the relationship between Hba1c level and MPV among type 2 diabetic individuals. Methodology: This was a retrospective study conducted from December 2022 to November 2023 in Muhammad Medical College and Hospital with prior approval from ethical committee via letter No: Physiol dated 10-03-20. By random sampling 370 participants were selected in which 214 were diabetics and 156 were non-diabetics. Their blood pressure, BMI, Hba1c level, fasting and post prandial glucose level was

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Habib, Tamanna Binte, Qazi Shamima Akhter, Hasan Imam, Nahid Yeasmin, Sharmin Nahar, and Farhana Rahman. "The potential benefit of omega-3 fatty acid capsule on Mean platelet volume and Platelet count in type-2 Diabetes Mellitu." Bangladesh Critical Care Journal 8, no. 1 (2020): 37–40. http://dx.doi.org/10.3329/bccj.v8i1.47707.

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Background: Diabetes Mellitus (DM) is a major non-communicable health problem that has effects on glycemic status. Hyperglycemia that is an inherent finding of diabetes causes platelet dysfunction. Oral omega-3 fatty acid supplementation may improve glycemic status in diabetic patient and reduce micro and macrovascular complications. Objective: To observe the effect of supplementation of omega-3 fatty acid on Mean Platelet Volume (MPV) and Platelet count in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52

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Amoghasiddha, S. Jyoti, K. Arun., and Shankar Anjali. "A Cross-Sectional Study For Evaluation of Platelet Indices in Patients With Type 2 Diabetes Mellitus." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 744–49. https://doi.org/10.5281/zenodo.11220890.

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<strong>Background: </strong>Diabetes mellitus has become a major global health problem. It’s a state of hyperglycemia which causes spectrum of long term systemic complications having considerable impact on individuals in their most productive years. Altered platelets have been reported in such patients and has been considered as a ‘prothrombotic state’. Identification of such patients can be easily made by simple routine haematological analysis which is a cost-effective tool that could possibly benefit the diabetic patients by preventive actions. <strong>Methods:&n

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Dubey, Ishan, Bindu Singh Gaur, and Roma Singh. "A study to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications." International Journal of Research in Medical Sciences 5, no. 3 (2017): 1042. http://dx.doi.org/10.18203/2320-6012.ijrms20170659.

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Background: Diabetes Mellitus is a global pandemic disease. The increased platelet activity is emphasized to play a role in the development of vascular complications of the metabolic disorder. Mean platelet volume (MPV) is an indicator of average size and activity of platelets. This study was conducted to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications.Methods: Total of 100 subjects was enrolled in the study. Sample for glucose estimation and platelet indices were collected and estimation were carried out by the auto-analyzer

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Seo, In-Ho, and Yong-Jae Lee. "Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review." Biomedicines 10, no. 11 (2022): 2697. http://dx.doi.org/10.3390/biomedicines10112697.

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Complete blood count (CBC) is one of the most common blood tests requested by clinicians and evaluates the total numbers and characteristics of cell components in the blood. Recently, many investigations have suggested that the risk of cancer, cardiovascular disease (CVD), arteriosclerosis, type 2 diabetes (T2DM), and metabolic syndrome can be predicted using CBC components. This review introduces that white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), hemoglobin (Hb), mean corpuscular volume (MCV), red cell distribution width (RDW), platelet count, mean platelet volume (MPV), and p

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Aygün, Kemal, Ayça Asma Sakalli, Halime Seda Küçükerdem, Olgu Aygün, and Özden Gökdemir. "Assessment of neutrophil/lymphocyte ratio and mean platelet volume values in patients with diabetes mellitus diagnosis: A case–control study." Medicine 103, no. 37 (2024): e39661. http://dx.doi.org/10.1097/md.0000000000039661.

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Diabetes mellitus, fundamentally characterized by hyperglycemia, leads to significant metabolic disturbances. Type 2 diabetes mellitus is a chronic, inflammatory, preventable metabolic disease that is a significant health issue globally. The neutrophil-to-lymphocyte ratio (NLR) is an essential marker of systemic inflammation. We aimed to reveal the relationship between long-term glucose control and NLR, mean platelet volume (MPV), and red blood cell width in patients with type 2 diabetes. This was a retrospective case–control study. A total of 3532 applications in 2 years time were identified.

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Dik, Yavuz. "How is NLR and PLR affected in Type 2 diabetes mellitus compared to healthy population?" Medical Science and Discovery 7, no. 2 (2020): 405–8. http://dx.doi.org/10.36472/msd.v7i2.351.

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Objective: Diabetes Mellitus (DM); has become an important public health problem in Turkey and in the world. In this study, we aimed to investigate the effect of neutrophil / lymphocyte ratio and platelet / lymphocyte ratio in diabetic patients compared to healthy population in terms of cost effectiveness. Material and Methods: A control group consisting of 82 diabetics and 85 healthy individuals who applied to the internal medicine outpatient clinic between January 2019 and November 2019 were included in the study. The patients were divided into two groups as those with diabetes and hea

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Joshi, Advait Anirudha, and Janice Jaison. "The Study of Platelet Parameters- Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in Type 2 Diabetes Mellitus." Annals of Pathology and Laboratory Medicine 6, no. 8 (2019): A407–413. http://dx.doi.org/10.21276/apalm.2467.

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Zvetkova, Elissaveta, Ivan Ivanov, Eugeni Koytchev, et al. "Hematological and Hemorheological Parameters of Blood Platelets as Biomarkers in Diabetes Mellitus Type 2: A Comprehensive Review." Applied Sciences 14, no. 11 (2024): 4684. http://dx.doi.org/10.3390/app14114684.

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Diabetes mellitus type 2 (DM2) is a hypercoagulable state with enhanced platelet (PLT) activation and increased clotting factor production. Simultaneously, the fibrinolytic cell system is inhibited due to the formation of clots with high fibrinolysis resistance. The stages of PLT “activation” have been well characterized microscopically, morphometrically, and nanomechanically using a light microscope, transmission electron microscope (TEM), scanning electron microscope (SEM), and atomic force microscope (AFM). Thrombocytes in an “activated” (procoagulant) state play a central role in two main

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Iqbal, Shamal, Kanwal Nazir Arbab, Maria Tasneem Khattak, Ambreen Ali, Alia Banori, and Mehwish Iqbal Khan. "A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study Design." Pakistan Journal of Medical and Health Sciences 16, no. 9 (2022): 850–52. http://dx.doi.org/10.53350/pjmhs22169850.

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Objective: The aim of the study is to evaluate the reactivity of platelet parameters in a patient suffering from Type 2 diabetes mellitus. Place and duration of study: The study is conducted at Pak International Medical College Hayatabad Peshawar (PIMC) during march 2021 march 2022. Material and Method: Cross sectional hospital based study design is carried out on 300 diabetic patients having type 2 diabetes mellitus which is considered as a test group and compared with 300 normal blood glucose levels containing individuals which is considered as a control group. The blood samples of diabetes

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Anyika, Christabel, Victory Oparaocha, Suma Alluri, Mahathi Thotakura, and Ashok Chakravarthy. "3019 – ROLE OF MEAN PLATELET VOLUME (MPV) AS A PREDICTIVE BIOMARKER IN DIABETES MELLITUS TYPE 2." Experimental Hematology 137 (August 2024): 104341. http://dx.doi.org/10.1016/j.exphem.2024.104341.

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OT, Sreejith, Lubna Zafar, Mujahid Beg, and Obaid Ahmed Siddiqui. "Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke." Journal of Neurosciences in Rural Practice 12, no. 04 (2021): 764–69. http://dx.doi.org/10.1055/s-0041-1735326.

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Abstract Background Stroke is the second leading cause of death in the world and a major cause of disability, with ischemic stroke contributing to 87% of all strokes. Platelets are central in the formation of thrombus, and in the process, they enlarge in size, become active, and secrete prothrombotic factors. This is supported by the presence of large platelets in ischemic stroke, where they may be implicated in the pathogenesis of vessel occlusion, leading to stroke. The mean platelet volume (MPV) is an important laboratory marker of platelet function and activation. Materials and Methods The

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Ghosh, Trisha, Sanjay Kumar Daulat Thakur, Premangshu Ghosh, and Trina Sengupta. "Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume in patients with diabetic retinopathy." Journal of Clinical Ophthalmology and Research 13, no. 1 (2025): 65–70. https://doi.org/10.4103/jcor.jcor_97_24.

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Objective: The objective of this study was to assess the role of inflammation in the pathogenesis of diabetic retinopathy (DR) using the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and to compare these parameter levels between DR and non-DR (NDR) subjects. Materials and Methods: A cross-sectional study was conducted among 60 patients with a definite diagnosis of type 2 diabetes mellitus attending the ophthalmology outpatient department of a tertiary care hospital. We obtained blood samples from all individuals who participated in the

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