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Journal articles on the topic 'Type 2 diabetes mellitus(Type 2 DM) Oral Hypoglycemic Agents (OHA) Insulin'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Krishna, T. Sharmila, C. Suvarna Devi, U. Sreedhar, R. Viswa Kumar, and M. Prasad Naidu. "Estimation of glycemic control in patients with type 2 diabetes mellites with various forms of tuberculosis with dots." International Journal of Clinical Biochemistry and Research 8, no. 2 (2021): 120–23. http://dx.doi.org/10.18231/j.ijcbr.2021.026.

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Since ancient times people are aware of the association between tuberculosis and diabetes mellitus. Patients with tuberculosis and diabetes experience worse clinical manifestations, increased risk of treatment failure, recurrence, and death. The present study was conducted to evaluate glycosylated hemoglobin (HbA1c) and blood glucose levels, in patients with Type - 2 diabetes mellitus with various forms of tuberculosis who are on RNTCP DOTS and antidiabetic regimens. The study subjects included Type-2 diabetes mellitus with tuberculosis who are registered under RNTCP DOTS, in Dept of Pulmonolo

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K.C., Indu. "Causes of Hypoglycemia in Hospitalized Diabetic Patients Referred to Endocrine Department of a Tertiary Level Hospital of India." Medical Journal of Shree Birendra Hospital 15, no. 1 (2016): 26–31. http://dx.doi.org/10.3126/mjsbh.v15i1.15018.

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Introduction: Diabetes mellitus (DM) results from relative deficiency or reduced effectiveness of endogenous insulin leading to both micro-vascular and macro-vascular complications. Treatment goal is intensive therapy as early as possible in patients with both type-1 and type-2 diabetes to bring the HbA1c to less than 7%. Occurrence of hypoglycemia in a diabetic patient is a common side effect of treatment. This study was aimed to find the causes of Hypoglycemia in diabetes patients. Methods: It was hospital based cross-sectional observational study on admitted diabetes patients with other co-

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Rajaragupathy, Sujatha, Deepika Ponnusamy, Dhanalakshmi Balasundararaj, Sandhiya Venkatesan, and Jayagowri Karthikeyan. "Serum megalin levels in type-2 diabetes mellitus with and without cardiovascular disease." Journal of Family Medicine and Primary Care 13, no. 11 (2024): 5240–43. http://dx.doi.org/10.4103/jfmpc.jfmpc_989_24.

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ABSTRACT Background: Low-density lipoprotein receptor-related protein-2 (LRP2), also called megalin, is a multi-ligand receptor of the LDL receptor gene family mediating reabsorption of ligands like Apo-A1. Type 2 diabetes mellitus (T2DM) may possibly disrupt megalin functions as it is found to be regulated by insulin. This might cause cardiovascular complications due to derangement in lipoprotein metabolism. The current study was carried out to assess the serum megalin levels among T2DM individuals with cardiovascular complications in the Indian population. Methods: This was a cross-sectional

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F. S, Mohammed, and Ansam N. Al-Hassani. "Clinical efficacy of Diabecon in treatment of type 2 diabetes mellitus, in newly diagnosed diabetic patients and in those on drug treatment (Glibenclamide and Metformin) in Erbil Governarate-Kurdistan Region/ Iraq." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 1 (2013): 44–51. http://dx.doi.org/10.32947/ajps.v13i1.177.

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Various herbs have been found beneficial in the management of type 2 diabetes and are gaining considerable recognition in the management of type 2diabetes worldwide. The present study was planned to evaluate the clinical efficacy of Diabecon (Herbal formulation) as a mono therapy and also as an adjunct with other oral hypoglycemic agents, in the management of type 2 DM. A total of 80 patients of either sex, between 30-68 years of age, in whom the diagnosis of type 2 diabetes was confirmed, and who were willing to give informed consent were included in the study.All enrolled patients were categ

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Gul, Nadia, Inayat Ur Rehman, Yasar shah, et al. "Comparing dual oral agents plus insulin vs. Triple oral agents in uncontrolled type II diabetes: A pilot study." PLOS ONE 19, no. 11 (2024): e0311435. http://dx.doi.org/10.1371/journal.pone.0311435.

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Introduction Type II Diabetes mellitus (T2DM) patients often do not achieve glycemic control with oral hypoglycemic agents (OHAs). There are two main approaches to address this challenge: transitioning to a triple OHA regimen, or adding Insulin to the existing dual OHA regimen. Aim This study aimed to compare the efficacy of adding Insulin to dual OHAs (Sitagliptin + Metformin) against adding a third OHA to Sitagliptin + Metformin in achieving glycemic control among patients with uncontrolled T2DM. Method A pre-post study was conducted between 21 September 2023 and 21 December 2023 at Services

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Antsiferov, M. B. "Initiation of insulin therapy for type 2 diabetes mellitus." Problems of Endocrinology 55, no. 5 (2009): 3–5. http://dx.doi.org/10.14341/probl20095553-5.

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This program is designed to identify patients in whom diabetes mellitus resists therapy with oral hypoglycemic agents (OHA) and basal insulin administration is needed to maintain the HbA1c at the desired level below 7. Data from 2895 patients (2034 women and 851 men) were available for analysis. Only 2.6% of the patients had the glycated hemoglobin (HbA1c) level within the normal values prior to the onset of therapy. The remaining ones had decompensated diabetes mellitus that required supplementation of regular OHA therapy with Lantus insulin. Characteristics of carbohydrate metabolism signifi

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Umesh, Teltumbade. "Assessment of Control of Cardiovascular Risk Factorsin Type-2 Diabetes." International Journal of Pharmaceutical and Clinical Research 14, no. 12 (2022): 735–40. https://doi.org/10.5281/zenodo.13881504.

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<strong>Introduction:</strong> Diabetic patients are at increased risk for coronary heart disease and experience increased morbidity and mortality from coronary heart disease compared to their non-diabetic counterparts. he specific factors that can make this expanded hazard include obesity, hyperglycemia, high blood pressure (BP), insulin resistance, and dyslipidemia. When patients are physically inactive or smokers and have at least one cardiometabolic risk factor, this markedly increases the cardiometabolic risk. Also, clustering of these risk factors can markedly increase the risk of c

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Azhar Memon, Shomail Saeed Siddiqui, Muhammad Atif Ata, Kashif Rasheed Shaikh, Umair Ali Soomro, and Shumaila Shaikh. "Silymarin improves glycemic control through reduction of insulin resistance in newly diagnosed patients of type 2 diabetes mellitus." Professional Medical Journal 29, no. 03 (2022): 362–66. http://dx.doi.org/10.29309/tpmj/2022.29.03.6477.

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Objective: To study, analyse and compare the effects of Silymarin on glycemic control and insulin resistance in newly diagnosed type 2 diaebtes mellitus (T2DM) subjects. Study Design: Observational study. Setting: Suleman Roshan Medical College Hospital. Period: March 2019 to February 2020. Material & Methods: A sample of 200 newly diagnosed cases of T2DM were recruited accroding to inclusion criteria selected by non-probability convenient sampling. Subjects were divided into 2 groups; OHA- oral hypoglycemia agent and OHA+ Sillymarin (200 mg). Baseline fasting (FBG) and random blood glucos

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Syed, Areefulla Hussainy* Mariyam Hyder Nameera Hyder Mariyam Firdous Sana Sultana and Dr Rafiya Sultana. "A PROSPECTIVE OBSERVATIONAL STUDY IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS AT TERTIARY CARE TEACHING HOSPITAL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6406–29. https://doi.org/10.5281/zenodo.1311187.

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<strong><em>AIM & OBJECTIVE: </em></strong><em>A prospective observational study in the treatment of Type 2 Diabetes Mellitus at tertiary care teaching hospital.</em> <strong><em>METHODOLOGY: </em></strong><em>A Prospective observational study carried out in the Department of general medicine in Osmania General Hospital, a tertiary care teaching hospital for a period of 6months. All the patients of either sex attending General medicine department with established type 2 Diabetes Mellitus were included in the study. In-patients already diagnosed of Type 2 diabetes mellitus and are on treatm

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Kaur, Pardeep, Munish Kumar, Jyoti Parkash, and D. N. Prasad. "Oral hypoglycemic drugs: An overview." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 770–77. http://dx.doi.org/10.22270/jddt.v9i3-s.2815.

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The aim of this study was to evaluate safety and efficacy of oral hypoglycemic agents in obese Type-2 diabetic patients. The objectives are to compare fasting and postprandial blood sugar (PPBS) levels, to compare body mass index in all the groups and to identify glycosylated hemoglobin levels and adverse drug reaction in all the groups. Diabetes mellitus is one of the world’s major diseases. It currently affects an estimated143 million people worldwide and the number is growing rapidly. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure

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Ageel, Hakma M., and Samia Hassan. "Relation between Different Types of Treatment and Glycemic Control in Diabetic Pregnant Women." Iraqi Journal of Industrial Research 8, no. 1 (2021): 62–67. http://dx.doi.org/10.53523/ijoirvol8i1id47.

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Gestational diabetes mellitus (GDM) is a common medical condition associated with pregnancy. GDM is defined as hyperglycemia that is diagnosed during pregnancy and is not clearly overt diabetes that existed prior to pregnancy. The sample of the study was sixty diabetic pregnant women who came for follow up at obstetrics and gynecology department in TMC in Tripoli medical center during the year 2016. The patients divided according to the type of treatments they received into three groups; A: Patients who took Oral hypoglycemic agents (OHA), B: Patients who took insulin, C: Patents who took both

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UG, Thakkar. "Type-1.5 Diabetes Mellitus with Autoimmune Hypothyroidism: A Rare Combination." Global Journal of Obesity, Diabetes and Metabolic Syndrome 3, no. 1 (2016): 008–10. https://doi.org/10.17352/2455-8583.000013.

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Autoimmune hypothyroidism may associate with type-1 Diabetes mellitus (DM) is a well-known entity as polyglandular autoimmune syndrome type-3. Type-1.5 DM is also known as late onset autoimmune mediated diabetes mellitus of adulthood (LADA) describing as- patients with type-2 diabetic phenotype based on age, not etiology combined with islet-cell antibodies and progressive β-cell failure, requiring life-time insulin therapy. Authors report a misdiagnosed type-2 diabetic since 3-years, of 35-years-male with known case of hypothyroidism had uncontrolled hyperglycemia, 12.7% glycosylated hemo

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More, Hardik, Dilip Patil, and Chahat Singh. "Clinical profile of diabetic ketoacidosis in type 2 diabetes patients at a tertiary care centre." International Journal of Research in Medical Sciences 12, no. 1 (2023): 178–82. http://dx.doi.org/10.18203/2320-6012.ijrms20233996.

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Background: The present study was undertaken to analyse the clinical profile of type 2 diabetes patients presenting with diabetic ketoacidosis at the time of presentation, owing to dearth of scientific enquiry into this research query. Methods: The present study was an analytical, cross-sectional study conducted over the period of two years. All the type 2 diabetes patients with diabetic ketoacidosis admitted during the study period constituted the study population, after being subjected to prefixed selection criteria. Detailed clinical history was recorded and thorough physical examination wa

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Alshadfan, Hisham, Hyder Mirghani, Tariq Alrasheed, Armania N. Urdin, and Muhammad Nazrul Hakim Abdullah. "Validation of the Arabic version of the oral hypoglycemic agent questionnaire version 2 (OHA-Q ver. 2) in Tabuk, Saudi Arabia: A pilot study." Edelweiss Applied Science and Technology 9, no. 5 (2025): 1882–92. https://doi.org/10.55214/25768484.v9i5.7331.

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Diabetes mellitus is common globally, and the Arab countries are no exception. Oral hypoglycemic agents are major pillars of diabetes management. The Oral Hypoglycemic Agent Questionnaire Version 2 (OHA-Q ver. 2) is unavailable in Arabic. Therefore, the study's goal was to validate the questionnaire for use among patients with diabetes in Saudi Arabia. Thirty patients with diabetes were randomly selected from those attending regular follow-ups at the King Fahd Specialist Hospital - Diabetes Center in Tabuk, Saudi Arabia. The study took place in March and April 2023. A structured questionnaire

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Pavlova, M. G., and I. V. Glinkina. "The effectiveness and safety of the supplementation of therapy with oral hypoglycemic agents by basal insulin in the patients with type 2 diabetes mellitus. Results of the SOLOS observational program." Problems of Endocrinology 59, no. 4 (2013): 65–68. http://dx.doi.org/10.14341/probl201359465-68.

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The results of numerous clinical investigations carried out during the last years provide convincing evidence of the high effectiveness and safety of early initiation of insulin therapy. Of special interest are the studies conducted under conditions of real clinical practice. One of them is the Russian SOLOS observational program designed to evaluate the influence of intensification of the treatment of type 2 diabetes mellitus with oral hypoglycemic agents (OHA) supplemented by using insulin glargine in the patients who failed to be adequately compensated by OHA therapy alone. Another objectiv

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Alla, Deekshitha, and Alla Sai Santhosha Mrudula. "A comprehensive review on the role of yoga in the management of type- 2 diabetes mellitus and its benefits over physical exercise in type 2 DM." International Journal of Research in Medical Sciences 10, no. 10 (2022): 2334. http://dx.doi.org/10.18203/2320-6012.ijrms20222546.

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Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia. It is caused either due to defective secretion of insulin or due to increased insulin resistance of peripheral tissue. The incidence of DM has increased in past decade due to sedentary lifestyle, altered dietary patterns, obesity etc. DM increases morbidity and mortality of individuals, thereby requiring great attention. In recent era, insulin and oral hypoglycemic agents are used in majority to treat DM. Recent studies have shown that simple lifestyle changes like dietary changes, yoga and physical exercise

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Luna, Nenuel Angelo B., and Leilani B. Mercado-Asis. "Giving Insulin Is Not a Guessing Game: Insulin Replacement Therapy in Type 2 Diabetes Mellitus." Journal of Medicine, University of Santo Tomas 6, no. 1 (2022): 868–80. http://dx.doi.org/10.35460/2546-1621.2022-0032.

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In 2021, 537 million adults were living with diabetes. Being a progressive disease, there would eventually be failure of oral hypoglycemic agents (OHA) to maintain good glycemic control and a majority will require insulin. However, optimal glycemic control has not been satisfactory in a significant proportion of patients who were on insulin therapy. Patient factors (eg, awareness, compliance, socioeconomic) have been identified but physician-related factors are as important. These include incorrect choice and inappropriate combination of insulin therapy which could be corrected by making the t

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Mukhtar, Y., A. Galalain, and U. Yunusa. "A MODERN OVERVIEW ON DIABETES MELLITUS: A CHRONIC ENDOCRINE DISORDER." European Journal of Biology 5, no. 2 (2020): 1–14. http://dx.doi.org/10.47672/ejb.409.

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Diabetes mellitus is one of the most common endocrine disorders that affect the body’s ability to make or use insulin. Diabetes mellitus (DM), or simply diabetes, is a group of chronic metabolic diseases in which a person experience high blood sugar, either because the pancreas does not produce enough insulin or because the body cells do not effectively use or respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Conventionally, diabetes has been divided i

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Ahmad, Hussain, and Md Abu Nayeem Chowdhury. "A Short Review on Anti-diabetics for Uncontrolled Type 2 Diabetes Mellitus." Medicine Today 31, no. 2 (2019): 120–27. http://dx.doi.org/10.3329/medtoday.v31i2.41966.

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Introduction: This article reviews the treatments available for patients with T2DM, with an emphasis on agents introduced within the last decade. Materials and Methods: This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include type 2 diabetes mellitus, prevalence, current diagnosis, and current treatment. Only articles in English were included. Materials & Methods: Screening and diagnosis is still based on World Health Organization (WHO) and American Diabetes Associat

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Ahmed, Sanaa, Hina Shah, Juwariah Sohail, Saba Rizwan, Sadia Khalil, and Mohsin Rizvi. "Frequency of Oral Lesions in Diabetic Patients on Oral Hypoglycemic Drugs and Insulin." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 495–97. http://dx.doi.org/10.53350/pjmhs2023173495.

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Background: Lichen planus is a pre-cancerous condition which is immune mediated. It is often linked with other autoimmune diseases such as Diabetes Mellitus. It is linked with both Type 1 and Type 2 DM. Methods: A retrospective cross-sectional study that was conducted at Jinnah Sindh Medical University on data of patients coming to Oral Medicine OPD from January 2020- December 2022. Diabetic patient`s data was extracted, and secondary analysis was done on it to find out the frequency of the lesions in both types. Results: Data of 211 patients were analyzed through SPSS ver. 20. Total of 30 pat

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Sneha, P. S.*1 Akhila. S. P.2 Ancy T. S. 3. Sree Lekshmi R. S.4 Prasobh G. R.5. "A Review On Type 2 Diabetes Mellitus." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3129–36. https://doi.org/10.5281/zenodo.13329994.

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Diabetes mellitus (DM) is a metabolic disease, involving inappropriately elevated blood glucose levels. Type 2 diabetes affects how your body uses sugar (glucose) for energy. It stops the body from using insulin properly, which can lead to high levels of blood sugar if not treated. T2DM also known as Non-Insulin Dependent Diabetes Mellitus (NIDDM)/Adult or Maturity onset Diabetes Mellitus. Over time, type 2 diabetes can cause serious damage to the body, especially nerves and blood vessels. Type 2 diabetes is often preventable.  Although type 2 DM predominantly affects older individuals, i

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Nielsen, Susan, Donna Kain, Elizabeth Szudzik, Sandeep Dhindsa, Rajesh Garg, and Paresh Dandona. "Use of Continuous Subcutaneous Insulin Infusion Pump in Patients With Type 2 Diabetes Mellitus." Diabetes Educator 31, no. 6 (2005): 843–48. http://dx.doi.org/10.1177/0145721705283078.

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Purpose In patients with type 2 diabetes, the control of hyperglycemia is often difficult despite full doses of oral hypoglycemic agents and extremely large doses of insulin. These patients pose a major management problem. The authors therefore investigated whether insulin given as a subcutaneous continuous infusion of insulin (CSII) would result in an improvement in glucose homeostasis. Methods Four patients with badly controlled type 2 diabetes, on treatment with extremely high doses of insulin and oral hypoglycemic agents, were started on CSII. Results All four patients had a marked improve

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Rukminingsih, Fef. "PENGGUNAAN INSULIN PADA PASIEN DIABETES MELITUS TIPE 2 PESERTA JKN DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT ST. ELISABETH SEMARANG." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 6, no. 1 (2021): 79–86. http://dx.doi.org/10.36387/jiis.v6i1.611.

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Diabetes mellitus (DM) type 2 is a chronic and progressive clinical syndrome, characterized by polyuria, polydipsi and polyphagy accompanied by increased blood glucose or hyperglycemia. Management of type 2 diabetes mellitus in patients with HbA1C values > 9% is by administering insulin or a combination of insulin with oral hypoglycemic agents. This study aims to determine the suitability of the type and dose of insulin in type 2 DM patients in the Outpatient Pharmacy Installation of St. Elisabeth Hospital Semarang. This research is a descriptive observational study using retrospective data

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Agrawal, Prabhat Kumar, Shiv Sagar Yadav, Sandipta Kumar Panda, and Sandeep Kumar. "Hypersensitivity reaction to NPH insulin in a patient with type 3c diabetes." National Journal of Pharmacology and Therapeutics 3, no. 1 (2025): 59–61. https://doi.org/10.4103/njpt.njpt_67_24.

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Abstract Insulin is the cornerstone in the management of diabetes mellitus (DM). Insulin allergy, although rare, poses a major challenge because of the lack of noninsulin treatment options in type 1 DM, the ultimate need for insulin therapy in type 2 diabetes with complications or not controlled on oral hypoglycemic agents, and limited noninsulin treatment options for conditions like type 3c and gestational diabetes. Immunological reactions to insulin have become increasingly infrequent owing to the many revolutionary changes in insulin biosynthesis since its discovery. Still, immunological re

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Satya, Abhishek Kombathula, and Moorthy Sachidananda. "Prescription Pattern of Anti-Diabetic Drugs In Type 2 Diabetes Mellitus Patients at a Tertiary Care Hospital – India." International Journal of Pharmaceutical and Clinical Research 16, no. 8 (2024): 1105–11. https://doi.org/10.5281/zenodo.13621383.

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<strong>Background: </strong>Understanding the prescription patterns of anti-diabetic drugs in Type 2 Diabetes Mellitus patients is crucial for optimizing treatment outcomes and addressing variations in clinical practices, ensuring effective disease management. <strong>Aim:</strong> To evaluate the prescription pattern of antidiabetic drugs in patients with type 2 diabetes mellitus. <strong>Materials & Methods: </strong>A prospective observational study was conducted at Konaseema Institute of Medical Sciences (KIMS) Hospital, from July 2022 to December 2022 after g

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Pagkalos, Emmanouil M. "Combinations of insulin and oral hypoglycemic agents in diabetes mellitus type 2." Diabetes Research and Clinical Practice 93 (August 2011): S100—S101. http://dx.doi.org/10.1016/s0168-8227(11)70022-5.

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BANDO, Hiroshi. "Useful Oral Administration of Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA) as Semaglutide (Rybelsus) for Type 2 Diabetes Mellitus (T2DM)." Asploro Journal of Biomedical and Clinical Case Reports 5, no. 1 (2022): 38–41. http://dx.doi.org/10.36502/2022/asjbccr.6260.

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As recommended pharmacological agents for type 2 diabetes mellitus (T2DM), Glucagon-Like Peptide 1 receptor agonist (GLP-1Ra) is highly evaluated for its various beneficial effects. Among them, semaglutide (Rybelsus) has been in focus for useful oral formation with useful oral hypoglycemic agent (OHA). Administration per os is possible due to the developed technique of absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate. Clinical efficacy was shown by a series of Peptide Innovation for Early Diabetes Treatment (PIONEER) with enough weight reduction and decreased HbA1c. From the

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Mohammed, Nesren Shaban, Esam Noori Al-Karwi, Ahmed Tariq Numan, and Saad Abdul-Rehman Hussain. "Effects of Low Doses of Captopril or Losartan in Improving Glycemic Control by Oral Hypoglycemic Agents in Type 2 DM Patients." Al Mustansiriyah Journal of Pharmaceutical Sciences 8, no. 2 (2010): 33–45. http://dx.doi.org/10.32947/ajps.v8i2.331.

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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both.Cross-talk between the rennin-angiotensin system (RAS) and insulin signaling has been demonstrated. The rennin angiotensin system (RAS) may regulatepancreatic islet blood flow, oxygen tension, and islet (pro) insulin biosynthesis.The present study was designed to evaluate the effect of low doses captopril and losartan, as adjunct treatment in uncontrolled type 2 DM patients treated with oral hypoglycemic agents alone.This double-blind placebo-co

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Theivasigamani, Kumutha, and Senthilkumar Palaniappan. "Prevalence and Incidence of Type-2 Diabetes Mellitus Among the Rural Population of Erode District of Tamil Nadu, South India." Journal of Advanced Zoology 44, no. 3 (2023): 663–71. http://dx.doi.org/10.17762/jaz.v44i3.1021.

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Diabetes mellitus is a group of metabolic disorders characterised by hyperglycaemia, caused by elevation of blood glucose level. A sedentary lifestyle is the most common cause of diabetes and has a wide range of long-term effects, including cardiovascular disease, kidney disease, blindness, and disability. Over the last two decades, diabetes has become more widespread in low and middle-income countries than in high-income countries. The study was aimed to determine the prevalence and incidence of type 2 diabetes mellitus among the rural population of Erode district, Tamil Nadu, India. A cross-

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M., Nithyapriya, and S. Purushotaman. "Efficacy and safety of bromocriptine quick release as an add on therapy with metformin and glipizide in type 2 diabetes mellitus patients: an open label randomized controlled study." International Journal of Basic & Clinical Pharmacology 8, no. 4 (2019): 669. http://dx.doi.org/10.18203/2319-2003.ijbcp20191097.

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Background: Type 2 Diabetes Mellitus (DM) is a metabolic disorder, treated by insulin and oral hypoglycaemic agents (OHA). Despite treatment, to protect diabetic population from its complications is difficult. So, there is a need for an OHA with different mechanism of action and minimal side effects. Bromocriptine Mesylate QR (Quick release) formulation was approved by FDA for treatment of type 2 DM. Hence, this study was planned to highlight the usefulness of Bromocriptine QR in type 2 diabetes mellitus.Methods: Total 140 patients with type 2 DM were randomized into two groups. The control gr

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Alnairi, Khalid, Sujoud Ghallab, Fatima Alslail, et al. "GLYCAEMIC CONTROL AMONG SAUDI PATIENTS WITH TYPE 2 DIABETES MELLITUS AT FIRST TIME REGISTRY IN RAQEB RECORDS FROM 2018-2022." International Journal of Advanced Research 11, no. 06 (2023): 867–75. http://dx.doi.org/10.21474/ijar01/17138.

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Background:Diabetes Mellitus (DM) is a major risk factor for many complications and glycaemic control prevents and delays such complications. The Raqeb registry aims toimprove diabetic patientscontrol of their diabetes by giving them glucometers. Objective:This study aims to determine the prevalence of type 2 diabetes (T2DM) glycaemic control in all regions of Saudi Arabia using Raqeb data, as well as outline the factors associated with uncontrolled T2DM. Methods:This paper conducted a registry-based cross-sectional study among all patients with T2DM who registered in Raqeb from October 16, 20

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Srivastava, Brijendra Kumar, Ranjit Mohan Anjana, Anandakumar Amutha, Muthu Ramuu, Manoharan Sriraam, and Viswanathan Mohan. "Judicious use of modern technology with antihyperglycemic agents: The changing landscape of type 2 diabetes management." Journal of Diabetology 15, no. 1 (2024): 119–22. http://dx.doi.org/10.4103/jod.jod_127_23.

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Abstract Background: Continuous subcutaneous insulin infusion (CSII) pump has shown good outcomes in patients with both type 1 and type 2 diabetes mellitus. Here, we present an individual with type 2 diabetes and obesity who was on a high dosage of insulin and oral hypoglycemic agents (OHA) were able to get diabetes under good control with weight reduction after using a hybrid artificial closed-loop insulin pump system along with glucagon-like peptide 1 receptor agonist (GLP-1RA) and sodium-glucose co-transporter-2 (SGLT-2) inhibitor. Case Presentation: A 60-year-old lady with type 2 diabetes

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Dr., Syed Farasat Ali Shah Dr. Eesha Noor Dr. Ifaza Tariq. "TO DETERMINE THE FREQUENCY OF HYPOGLYCAEMIA IN DIABETIC PATIENTS TAKING ORAL HYPOGLYCAEMIC DRUGS/ INSULIN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 12376–81. https://doi.org/10.5281/zenodo.1490073.

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<strong><em>Background: </em></strong><em>The risk of severe hypoglycemia is greatly increased in subjects having old age, renal failure, hepatic failure and pregnancy. The overall prevalence is 2–3%, and the lifetime risk is around 15%. </em> <strong><em>Objective: </em></strong><em>To determine the frequency of hypoglycemia in diabetic subjects taking oral hypoglycemic agents/ Insulin therapy.</em> <strong><em>Method: </em></strong><em>This cross-sectional study includes 250 out/in patient type 2 diabetic subjects visiting to Pakistan Institute of Medical Sciences that is a tertiary ca

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Dr., V. Ashwin Karuppan*, Aafrin Shabbir Dr., and Deepika Ganesh Dr. "ASSESSMENT OF AWARNESS ABOUT HYPOGLYCEMIA IN DIABETIC PATIENTS IN SOUTH INDIA – HYPO D STUDY." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 933–41. https://doi.org/10.5281/zenodo.15302918.

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Hypoglycemia or low blood sugar means a blood glucose reading lower than 70 milligrams per deciliter (mg/dL). Hypoglycemia is common among people with Type 1 and Type 2 Diabetes Mellitus patients who are receiving pharmacological therapies like insulin or oral hypoglycemic agents (OHAs). In a study conducted globally it was shown that at least 4 in 5 people with Type 1 Diabetes Mellitus and half the Type 2 Diabetes Mellitus patients have reported an experience of hypoglycemia at least once.

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Zelinska, N. B., K. V. Grishchenko, and E. V. Globa. "Type 2 diabetes mellitus in children and adolescents in the world and in Ukraine." Ukrainian Journal of Pediatric Endocrinology, no. 1 (December 6, 2021): 4–16. http://dx.doi.org/10.30978/ujpe2021-1-4.

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Introduction. Recently, many studies have been devoted to the study of type 2 diabetes mellitus (DM2) worldwide. In most countries of the world, the increase in the prevalence of DM2 among children and adolescents is accompanied by an increase in childhood obesity. The presence of obesity or overweight in children can complicate the diagnosis of various types of DM. Detection and treatment of DM2 is extremely important for the society due to the wide range of severe diabetes complications.The aim of this work was to analyze the frequency of DM2 according to the Register of patients with DM, an

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Umamaheswari, A., K. Bhuvaneswari, and R. Senthilkumar. "To Compare the Anti-Inflammatory Effect of Oral Hypoglycemic Drugs in Type 2 Diabetes Mellitus." Biomedical and Pharmacology Journal 11, no. 3 (2018): 1667–74. http://dx.doi.org/10.13005/bpj/1535.

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Insulin resistance and endothelial dysfunction which shares multiple signaling pathways like hyperinsulinemia, glucotoxicity and inflammation in type 2 Diabetes Mellitus (DM) leads to several micro and macrovascular complications. Studies have shown the anti-inflammatory effects of certain oral hypoglycemic agents which will be helpful in preventing the impact of diabetes related complications. The study aimed to compare the anti-inflammatory effects of Sitagliptin and Acarbose in combination with Metformin and Sulfonylurea in Type 2DM patients by using Anti-inflammatory markers Interleukin-6

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Brahmbhatt, Shruti Vihang, and Bhagya M. Sattigeri. "A study on management of type 2 diabetic patients with complications." International Journal of Basic & Clinical Pharmacology 8, no. 8 (2019): 1870. http://dx.doi.org/10.18203/2319-2003.ijbcp20193193.

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Background: Diabetes is a major public health problem both in developing and non-developing countries across the world. It is a chronic disease, which in long term causes several complications resulting in poly pharmacy for its management. Hence, this study was determined to analyze the drug utilization pattern for the management of type 2 diabetes with complications.Methods: A prospective, observational and non-interventional study was carried out in 100 diabetic patients with one or other complications admitted in medicine wards at Dhiraj Hospital. Patients who signed informed consent form w

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He, Dan, and Can Cui. "Plant Heteropolysaccharides as Potential Anti-Diabetic Agents: A Review." Current Issues in Molecular Biology 47, no. 7 (2025): 533. https://doi.org/10.3390/cimb47070533.

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Diabetes mellitus (DM), a chronic metabolic disease, poses a significant challenge to global health. Although type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM), and other types of diabetes mellitus differ in pathological mechanisms, they converge in that hyperglycemia is a universal clinical hallmark. Currently, the antidiabetic medications employed in clinical practice for blood glucose management require long-term administration and are associated with various side effects that can adversely impact human health. Plant heteropolysaccharides

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Yu, Sung-Hsun, Szu-Yu Tina Chen, Wei-Shan Li, et al. "Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia ofCordyceps militarisin High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice." Journal of Diabetes Research 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/723190.

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Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion. Hypoglycemic medications for type 2 DM have either proven inadequate or posed adverse effects; therefore, the Chinese herbal products are under investigation as an alternative treatment. In this study, a novel combination of fruiting body and mycelia powder of herbalCordyceps militarisnumber 1 (CmNo1) was administered to evaluate their potential hypoglycemic effects in high-fat diet- (HFD-) induced type 2 DM in C57BL/6J mice. Body weight, fasting blood gluco

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Ametov, Alexander Sergeevich, and Ekaterina Vladimirovna Karpova. "Efficacious and safe management of type 2 diabetes mellitus using DPP-4 inhibitors." Diabetes mellitus 13, no. 2 (2010): 69–75. http://dx.doi.org/10.14341/2072-0351-5677.

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Diabetes mellitus (DM) is believed to be the third most frequent direct cause of death after cardiovascular and oncological diseases. Therefore, solutionof DM-related problems is a major challenge facing health authorities in many countries. No doubt, strict control of glycemia is an indispensablecondition for the reduction of the frequency of diabetic complications. Indeed, many strategies developed in the recent years allowed metabolic controlin DM patients to be significantly improved. Basic and clinical research of the last decade provided a basis for the development of highly promisingtre

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Alenezi, Helal S., Mubasher Kharal, Muhammad Yousuf, Yousef Al Saleh, and Salih Bin Salih. "Glycemic Control of Type 2 Diabetic Patients Managed in Tertiary Care Internal Medicine Clinics Using HbA1c." Saudi Journal of Internal Medicine 3, no. 1 (2013): 23–28. http://dx.doi.org/10.32790/sjim.2013.3.1.5.

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Background /Objective: The aim was to assess the glycemic control in patients with type 2 diabetes mellitus using American Diabetes Association HbA1c definition of good control of â‰¤ 7.0%. Methods: This retrospective study conducted in internal medicine outpatient clinics at King Abdulaziz Medical City in Riyadh, Kingdom of Saudi Arabia. All patients with type 2 diabetes mellitus attending the clinic from August 2005 to January 2006 were evaluated. Patients with HbA1c measured regularly and under anti-diabetic therapy were included in the study. Last measured HbA1c was used to evaluate

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Alenezi, Helal S., Mubasher Kharal, Muhammad Yousuf, Yousef Al Saleh, and Salih Bin Salih. "Glycemic Control of Type 2 Diabetic Patients Managed in Tertiary Care Internal Medicine Clinics Using HbA1c." Saudi Journal of Internal Medicine 3, no. 1 (2013): 23–28. http://dx.doi.org/10.32790/sjim.3.1.5.

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Background /Objective: The aim was to assess the glycemic control in patients with type 2 diabetes mellitus using American Diabetes Association HbA1c definition of good control of â‰¤ 7.0%. Methods: This retrospective study conducted in internal medicine outpatient clinics at King Abdulaziz Medical City in Riyadh, Kingdom of Saudi Arabia. All patients with type 2 diabetes mellitus attending the clinic from August 2005 to January 2006 were evaluated. Patients with HbA1c measured regularly and under anti-diabetic therapy were included in the study. Last measured HbA1c was used to evaluate

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Contini, Amanda G. M. R. da Fonseca S., and Estevan M. S. Contini. "FISIOPATOLOGIA DO DIABETES MELLITUS." Revista ft 29, no. 143 (2025): 34–35. https://doi.org/10.69849/revistaft/pa10202502240634.

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This study addresses Diabetes Mellitus (DM), a chronic disease with a high global prevalence, characterized by glucose metabolism disorders due to insulin deficiency or resistance. The research reviewed the pathophysiology of diabetes, highlighting the importance of glucose in the body, insulin secretion mechanisms by the pancreas, and the different types of the disease, including Type 1, Type 2, and Gestational Diabetes. Diagnostic methods such as fasting blood glucose, oral glucose tolerance test, and glycated hemoglobin were analyzed, along with the main symptoms of the disease, such as pol

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Glinkina, I. V. "Results of the observational program on the use of insulin glargine (Lantus) in combination with oral hypoglycemic agents or prandial insulins for the treatment of type 2 diabetes mellitus in routine clinical practice." Problems of Endocrinology 56, no. 5 (2010): 61–66. http://dx.doi.org/10.14341/probl201056561-66.

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The objective of this observational program was to evaluate the efficiency and safety of insulin glargine used to treat patients with type 2 diabetes mellitus (DM2) who failed to achieve adequate compensation of carbohydrate metabolism during therapy with NPC insulin in combination with oral hypoglycemic agents or prandial insulins. The secondary objective was to estimate satisfaction of physicians with the results of insulin glargine therapy. The open, prospective non-randomized multicentre observational study included 7.334 patients of the mean age 58.3±9.0 years presenting with type 2 diabe

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*, Dr. N. Tendu Pranadeep Dr. G. Gayathri Dr. B.Kavya Chowdary Dr.M.Anuhya Dr.C. Pradeep Dr. G. V. Nagaraju Dr.Md.K.Rahman Dr. Alias Kenny. "SAFETY AND EFFICACY OF TENELIGLIPTIN OVER OTHER HYPOGLYCEMIC AGENTS IN TYPE-2 DIABETES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6325–40. https://doi.org/10.5281/zenodo.1310608.

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To compare the safety and efficacy of the Teneligliptin a DPP inhibitor over other hypoglycaemic agents in Type II Diabetes Mellitus. .It is a prospective –observational study in this study was conducted at, Pradeep Diabetic Centre, Rajamahendravaram and the study was carried out for a period of 6 months from Feb 2016 to July 2016, and we are taking total of 114 patients with type 2 diabetes, in our study concludes the combination of Teneligliptin with other oral hypoglycaemic agents have been shown to improve glycaemic control efficiently when compare with the monotherapy shown inadequa

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Li, Ming, and Susumu Ikehara. "Bone Marrow Stem Cell as a Potential Treatment for Diabetes." Journal of Diabetes Research 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/329596.

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Diabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood glucose levels resulting from defects in insulin secretion and insulin action. The chronic hyperglycemia damages the eyes, kidneys, nerves, heart, and blood vessels. Curative therapies mainly include diet, insulin, and oral hypoglycemic agents. However, these therapies fail to maintain blood glucose levels in the normal range all the time. Although pancreas or islet-cell transplantation achieves better glucose control, a major obstacle is the shortage of donor organs. Recently, research has focused on stem

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Mishra, Vijay, Pallavi Nayak, Mayank Sharma, et al. "Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update." Pharmaceutics 13, no. 10 (2021): 1568. http://dx.doi.org/10.3390/pharmaceutics13101568.

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The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediated functional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, l

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Ramakrishnan, Santosh, Anantharaman Ramakrishnan, Rohit Warrier, and Shanmugasundar Gopal. "Hydroxychloroquine (HCQS) for glycaemic control: a remarkable turnaround in a patient with Type 2 DM." Journal of Endocrinological Science 2, no. 1 (2020): 1–3. http://dx.doi.org/10.29245/2767-5157/2020/1.1104.

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We describe a case where we effectively managed chronic, uncontrolled type 2 diabetes with hydroxychloroquine (HCQS) as an add on therapy, wherein the patient was on multiple oral hypoglycemic agents along with a combination of injectable incretin/insulin therapy prior to HCQS initiation. Six months into combination therapy with HCQS, the target HbA1c was achieved for the first time in the patient’s recent history at a much lower daily insulin dose (56% requirement drop), which has never been documented before. This combination also resulted in significant weight loss. We make a case for advoc

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Kumar Mandavi, Yunesh, Hari Prasad Sonwani, and Jayvant Kumar Sahu. "Type 2 Diabetes Mellitus in Adult; Pathogenesis and Therapy: A review." International Journal of Advanced Multidisciplinary Research and Studies 5, no. 1 (2025): 1193–98. https://doi.org/10.62225/2583049x.2025.5.1.3783.

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Type 2 diabetes mellitus (DM) is a long-term metabolic condition with a steadily rising prevalence worldwide. This trend has led to its classification as an epidemic in certain countries, with the number of affected individuals projected to double over the next decade. This increase is largely attributed to an aging population, further straining healthcare systems, particularly in underdeveloped nations. This review draws upon data from Medline, the Cochrane Database of Systematic Reviews, and reference lists of pertinent publications. The search focused on subject headings and keywords such a

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Qasim, Bayar Ahmed, Mazyar Jabbar Ahmed, and Ayad Ahmad Mohammed. "Incidence of hypoglycemia among patients with type 2 diabetes who fasted during Ramadan." Advanced medical journal 9, no. 1 (2024): 160–66. http://dx.doi.org/10.56056/amj.2024.248.

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Background and Objectives: Fasting causes a major change in the dietary habits including the frequency, the timing, and the patterns which will result in a major change in the metabolic response of the body. Physicians should advise the patients about the complications of diabetes mellitus during fasting especially hypoglycemia, the aim of this study is to determine the relation between fasting Ramadan in type 2 diabetes and hypoglycemia risk. Methods: This is a cross-sectional prospective study, which included 304 Muslim patients with type 2 diabetes mellitus who are receiving oral hypoglycem

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