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Journal articles on the topic 'Type 2/genetics'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ahlqvist, Emma, Tarunveer Singh Ahluwalia, and Leif Groop. "Genetics of Type 2 Diabetes." Clinical Chemistry 57, no. 2 (2011): 241–54. http://dx.doi.org/10.1373/clinchem.2010.157016.

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BACKGROUND Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the disease-affecting genes to better understand the disease pathogenesis, find new targets for clinical therapy, and allow prediction of disease. CONTENT Our knowledge about the genes involved in disease pathogenesis has increased substantially in recent years, thanks to genomewide association studies and international collaborations joining efforts to collect the huge numbers of individuals needed to study complex diseases on a po

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2

Ali, Omar. "Genetics of type 2 diabetes." World Journal of Diabetes 4, no. 4 (2013): 114. http://dx.doi.org/10.4239/wjd.v4.i4.114.

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3

Barroso, I. "Genetics of Type 2 diabetes." Diabetic Medicine 22, no. 5 (2005): 517–35. http://dx.doi.org/10.1111/j.1464-5491.2005.01550.x.

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4

Smushkin, Galina, and Adrian Vella. "Genetics of type 2 diabetes." Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 4 (2010): 471–77. http://dx.doi.org/10.1097/mco.0b013e32833a558d.

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5

Owen, Katharine R., and Mark I. McCarthy. "Genetics of type 2 diabetes." Current Opinion in Genetics & Development 17, no. 3 (2007): 239–44. http://dx.doi.org/10.1016/j.gde.2007.04.003.

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6

McCarthy, Mark I., and Eleftheria Zeggini. "Genetics of type 2 diabetes." Current Diabetes Reports 6, no. 2 (2006): 147–54. http://dx.doi.org/10.1007/s11892-006-0026-7.

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7

Lindgren, Cecilia M., and Joel N. Hirschhorn. "The Genetics of Type 2 Diabetes." Endocrinologist 11, no. 3 (2001): 178–87. http://dx.doi.org/10.1097/00019616-200105000-00004.

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8

McCarthy, Mark, and Stephan Menzel. "The genetics of type 2 diabetes." British Journal of Clinical Pharmacology 51, no. 3 (2001): 195–99. http://dx.doi.org/10.1046/j.1365-2125.2001.00346.x.

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9

Gloyn, Anna L., and Mark I. McCarthy. "The genetics of type 2 diabetes." Best Practice & Research Clinical Endocrinology & Metabolism 15, no. 3 (2001): 293–308. http://dx.doi.org/10.1053/beem.2001.0147.

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10

Malecki, Maciej T. "Genetics of type 2 diabetes mellitus." Diabetes Research and Clinical Practice 68 (June 2005): S10—S21. http://dx.doi.org/10.1016/j.diabres.2005.03.003.

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11

Newbury-Ecob, R. "Atelosteogenesis type 2." Journal of Medical Genetics 35, no. 1 (1998): 49–53. http://dx.doi.org/10.1136/jmg.35.1.49.

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12

Evans, D. G. R. "Neurofibromatosis type 2." Journal of Medical Genetics 37, no. 12 (2000): 897–904. http://dx.doi.org/10.1136/jmg.37.12.897.

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13

Taylor, Alan. "The genetics of type 2 diabetes: A review." International Journal of Diabetes and Metabolism 14, no. 2 (2006): 76–81. http://dx.doi.org/10.1159/000497595.

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Because of the widespread distribution and increasing prevalence of Type 2 diabetes in modern society, great efforts have been made to understand the underlying causes of the disease. The fact that the cause of Type 2 diabetes is primarily of genetic origin has been known for many years. In the last five years advances in the microarray analysis of gene expression and statistical genetics had provided hope that these techniques would give a clear identification of the genes involved and an understanding of the genetic nature of the disease. An analysis of recent work in this area has been carr

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14

Laakso, Markku, and Lilian Fernandes Silva. "Genetics of Type 2 Diabetes: Past, Present, and Future." Nutrients 14, no. 15 (2022): 3201. http://dx.doi.org/10.3390/nu14153201.

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Diabetes has reached epidemic proportions worldwide. Currently, approximately 537 million adults (20–79 years) have diabetes, and the total number of people with diabetes is continuously increasing. Diabetes includes several subtypes. About 80% of all cases of diabetes are type 2 diabetes (T2D). T2D is a polygenic disease with an inheritance ranging from 30 to 70%. Genetic and environment/lifestyle factors, especially obesity and sedentary lifestyle, increase the risk of T2D. In this review, we discuss how studies on the genetics of diabetes started, how they expanded when genome-wide associat

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15

Read, Renee D., Paul J. Goodfellow, Elaine R. Mardis, Nancy Novak, Jon R. Armstrong, and Ross L. Cagan. "A Drosophila Model of Multiple Endocrine Neoplasia Type 2." Genetics 171, no. 3 (2005): 1057–81. http://dx.doi.org/10.1534/genetics.104.038018.

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16

Fakruddin, Md. "Genetics of Type 2 Diabetes: A Review." Journal of Current and Advance Medical Research 6, no. 1 (2019): 59–63. http://dx.doi.org/10.3329/jcamr.v6i1.40787.

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Diabetes Mellitus (DM), one of the most non-communicable diseases, is increasing day by day in an alarming way. More than 140 million people are suffering from diabetes throughout the world. It is not a single disease entity, but rather a group of metabolic disorders sharing the common underlying feature of hyperglycemia. Hyperglycemia in diabetes results from defects in insulin secretion, insulin action, or, most commonly, both. The chronic hyperglycemia and attendant metabolic deregulation may be associated with secondary damage in multiple organ systems, especially the kidneys, eyes, nerves

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17

Bonnefond, Amélie, Philippe Froguel, and Martine Vaxillaire. "The emerging genetics of type 2 diabetes." Trends in Molecular Medicine 16, no. 9 (2010): 407–16. http://dx.doi.org/10.1016/j.molmed.2010.06.004.

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18

Groop, Leif, and Valeriya Lyssenko. "Genetics of type 2 diabetes. On overview." Endocrinología y Nutrición 56 (December 2009): 34–37. http://dx.doi.org/10.1016/s1575-0922(09)73515-6.

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19

Gill-Carey, Olivia, and Andrew T. Hattersley. "Genetics and type 2 diabetes in youth." Pediatric Diabetes 8, s9 (2007): 42–47. http://dx.doi.org/10.1111/j.1399-5448.2007.00331.x.

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20

Temelkova-Kurktschiev, T., and T. Stefanov. "Lifestyle and Genetics in Obesity and type 2 Diabetes." Experimental and Clinical Endocrinology & Diabetes 120, no. 01 (2011): 1–6. http://dx.doi.org/10.1055/s-0031-1285832.

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AbstractObesity and type 2 diabetes mellitus are multifactorial health threats caused by a complex interplay between genetic predisposition and the environment with dramatically increasing worldwide prevalence. The role of heritability in their etiology is well recognized, however, the numerous attempts made in order certain genetic variants determining individual susceptibility to be identified have had limited success, until recently. At present the advancements in human genetics and the utilization of the genome-wide association approach have led to the identification of over 20 genetic loc

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21

KISELEVA, T. A., F. V. VALEEVA, D. R. ISLAMOVA, and M. S. MEDVEDEVA. "Genetic aspects of type 2 diabetes mellitus." Practical medicine 21, no. 3 (2023): 14–18. http://dx.doi.org/10.32000/2072-1757-2023-3-14-18.

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Type 2 diabetes mellitus (DM2) is a polygenic, multifactorial disease resulting from the interaction of genetic, epigenetic and environmental factors. Given the significant genetic and genomic research in this area, the role of genetic factors in the pathogenesis of DM2 is becoming increasingly clear. The review presents current information in the genetics of DM2, describes the technology of genome wide-associated system (GWAS) based on high-resolution biochips for the simultaneous analysis of thousands of genetic variants in a large number of patients. Due to the use of genome-wide studies, a

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22

Alyavi, A., D. Tulyaganova, D. Dalimova, T. Khan, D. Rajabova, and S. Ashirbaev. "THE ROLE OF SOME POLYMORPHISMS IN THE COURSE OF ISCHEMIC HEART DISEASE ASSOCIATED WITH TYPE 2 DIABETES MELLITUS." POLISH JOURNAL OF SCIENCE, no. 82 (January 20, 2025): 23–31. https://doi.org/10.5281/zenodo.14707908.

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The identification of the coronary heart disease (CHD) locus was a landmark discovery in the genetics of cardiovascular disease. Like many other important advances in science, it was facilitated by advances in technology, in this case the availability of dense gene arrays. These arrays have made it possible to study genetic variation at the genome-wide level with reasonable coverage. This has enabled hypothesis-free approaches to studying the genetic components of disease using genome-wide association studies (GWAS). To date, GWAS have been extremely successful in identifying new genetic facto

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23

Al-Muftah, Wadha. "Genetics of Type 2 Diabetes among Qatari Families." Qatar Foundation Annual Research Forum Proceedings, no. 2011 (November 2011): BMPS7. http://dx.doi.org/10.5339/qfarf.2011.bmps7.

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24

Prasad, Rashmi, and Leif Groop. "Genetics of Type 2 Diabetes—Pitfalls and Possibilities." Genes 6, no. 1 (2015): 87–123. http://dx.doi.org/10.3390/genes6010087.

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25

Dorajoo, Rajkumar, Jianjun Liu, and Bernhard Boehm. "Genetics of Type 2 Diabetes and Clinical Utility." Genes 6, no. 2 (2015): 372–84. http://dx.doi.org/10.3390/genes6020372.

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26

Tonyan, Ziravard N., Yulia A. Nasykhova, Maria M. Danilova, and Andrey S. Glotov. "Genetics of macrovascular complications in type 2 diabetes." World Journal of Diabetes 12, no. 8 (2021): 1200–1219. http://dx.doi.org/10.4239/wjd.v12.i8.1200.

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27

Radha, V., S. Kanthimathi, and V. Mohan. "Genetics of Type 2 diabetes in Asian Indians." Diabetes Management 1, no. 3 (2011): 309–24. http://dx.doi.org/10.2217/dmt.11.14.

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28

Zeggini, E. "A new era for Type 2 diabetes genetics." Diabetic Medicine 24, no. 11 (2007): 1181–86. http://dx.doi.org/10.1111/j.1464-5491.2007.02274.x.

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29

Florez, Jose C. "Leveraging Genetics to Advance Type 2 Diabetes Prevention." PLOS Medicine 13, no. 7 (2016): e1002102. http://dx.doi.org/10.1371/journal.pmed.1002102.

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30

Hu, Gang, Jesús Rico-Sanz, Timo A. Lakka, and Jaakko Tuomilehto. "Exercise, genetics and prevention of type 2 diabetes." Essays in Biochemistry 42 (November 27, 2006): 177–92. http://dx.doi.org/10.1042/bse0420177.

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Type 2 diabetes is one of the fastest growing public health problems in both developed and developing countries. Cardiovascular disease is the most prevalent complication of type 2 diabetes. In the past decade, the associations of physical activity, physical fitness and changes in the lifestyle with the risk of type 2 diabetes have been assessed by a number of prospective studies and clinical trials. A few studies have also evaluated the joint associations of physical activity, body mass index and glucose levels with the risk of type~2 diabetes. The results based on prospective studies and cli

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31

Raciti, Gregory Alexander, Michele Longo, Luca Parrillo, et al. "Understanding type 2 diabetes: from genetics to epigenetics." Acta Diabetologica 52, no. 5 (2015): 821–27. http://dx.doi.org/10.1007/s00592-015-0741-0.

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32

Fressinaud, Edith, Claudine Mazurier, and Dominique Meyer. "Molecular Genetics of Type 2 von Willebrand Disease." International Journal of Hematology 75, no. 1 (2002): 9–18. http://dx.doi.org/10.1007/bf02981973.

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33

Cox, Nancy J. "Calpain 10 and genetics of type 2 diabetes." Current Diabetes Reports 2, no. 2 (2002): 186–90. http://dx.doi.org/10.1007/s11892-002-0079-1.

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34

QI, Qibin, and Frank B. HU. "Genetics of type 2 diabetes in European populations." Journal of Diabetes 4, no. 3 (2012): 203–12. http://dx.doi.org/10.1111/j.1753-0407.2012.00224.x.

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35

Alcolado, JC, MG Baroni, and DJ Galton. "The Molecular Genetics of type 2 Diabetes Mellitus." Clinical Science 81, s25 (1991): 13P. http://dx.doi.org/10.1042/cs081013pb.

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36

Jan, A., H. Jan, and Z. Ullah. "Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus." Diabetes mellitus 24, no. 4 (2021): 371–76. http://dx.doi.org/10.14341/dm12313.

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The genetics of Type 2 diabetes a complex metabolic disorder, characterized by decreased insulin secretion and insulin resistance resulting in impaired blood glucose homeostasis remains enigma for geneticists. In 2006 an important step while finding genetic causes of diabetes type 2 was identification of transcription factor 7-like 2 (TCF7L2) gene an important marker in predisposition of type 2 diabetes in almost all ethnic population. Recent genetic research identifies numerous novel type 2 diabetes susceptible genes among these genes TCF7L2 is considered as gang head and emerged as the most

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37

Balakhanim, Amiraslanova, and Asadova Basti. "LARGEST STUDY ON GENETIC RISK FOR TYPE 2 DIABETES." Deutsche internationale Zeitschrift für zeitgenössische Wissenschaft 99 (March 6, 2025): 5–7. https://doi.org/10.5281/zenodo.14981722.

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The diabetes field has long classified the disorder into genetically distinct groups, including type 1 and type 2. However, new genetics research focused on a form of type 2 diabetes (T2D) that is becoming more common in adolescents suggests a more complicated picture. Researchers at the Broad Institute of MIT and Harvard, Boston Children's Hospital, and Harvard Medical School analyzed DNA from more than 3,000 T2D participants between 12 and 18-years-old and nearly 9,800 adult controls, more than three-quarters of whom were of African American or Hispanic ancestry. They found that youth-onset

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38

Busch, CP, and RA Hegele. "Genetic determinants of type 2 diabetes mellitus." Clinical Genetics 60, no. 4 (2001): 243–54. http://dx.doi.org/10.1034/j.1399-0004.2001.600401.x.

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39

Engelhardt, H., M. Staudt, A. Hässler, U. Holzbach, P. Freisinger, and I. Krägeloh-mann. "Carbohydrate-deficient glycoprotein syndrome type 2." Journal of Inherited Metabolic Disease 22, no. 2 (1999): 192–93. http://dx.doi.org/10.1023/a:1005422610091.

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40

Oost, Lynette J., Roderick C. Slieker, Marieke T. Blom, et al. "Genome-wide association study of serum magnesium in type 2 diabetes." Genes & Nutrition 19, no. 1 (2024): 2. https://doi.org/10.1186/s12263-024-00738-5.

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People with type 2 diabetes have a tenfold higher prevalence of hypomagnesemia, which is suggested to be caused by low dietary magnesium intake, medication use, and genetics. This study aims to identify the genetic loci that influence serum magnesium concentration in 3466 people with type 2 diabetes. The GWAS models were adjusted for age, sex, eGFR, and HbA1c. Associated traits were identified using publicly available data from GTEx consortium, a human kidney eQTL atlas, and the Open GWAS database. The GWAS identified a genome-wide significant locus in<i>TAF3</i>(<i>p</i> = 2.9 × 10<sup>−9</su

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41

Peczkowska, Mariola, and Andrzej Januszewicz. "Multiple endocrine neoplasia type 2." Familial Cancer 4, no. 1 (2005): 25–36. http://dx.doi.org/10.1007/s10689-005-0656-y.

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42

Mohan, V., and Radha Venkatesan. "Genetics in diabetes: Type 2 diabetes and related trait." Indian Journal of Medical Research 143, no. 6 (2016): 838. http://dx.doi.org/10.4103/0971-5916.192084.

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43

Leong, Aaron, and James B. Meigs. "Type 2 Diabetes Prevention: Implications of Hemoglobin A1c Genetics." Review of Diabetic Studies 12, no. 3-4 (2015): 351–62. http://dx.doi.org/10.1900/rds.2015.12.351.

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44

Kim, Daniel Seung, Anna L. Gloyn, and Joshua W. Knowles. "Genetics of Type 2 Diabetes: Opportunities for Precision Medicine." Journal of the American College of Cardiology 78, no. 5 (2021): 496–512. http://dx.doi.org/10.1016/j.jacc.2021.03.346.

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45

Hansen, Lars, and Oluf Pedersen. "Genetics of type 2 diabetes mellitus: status and perspectives." Diabetes, Obesity and Metabolism 7, no. 2 (2005): 122–35. http://dx.doi.org/10.1111/j.1463-1326.2004.00396.x.

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46

Hagberg, J. M., N. T. Jenkins, and E. Spangenburg. "Exercise training, genetics and type 2 diabetes-related phenotypes." Acta Physiologica 205, no. 4 (2012): 456–71. http://dx.doi.org/10.1111/j.1748-1716.2012.02455.x.

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47

Herder, Christian, and Michael Roden. "Genetics of type 2 diabetes: pathophysiologic and clinical relevance." European Journal of Clinical Investigation 41, no. 6 (2010): 679–92. http://dx.doi.org/10.1111/j.1365-2362.2010.02454.x.

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48

Watanabe, R. M., M. H. Black, A. H. Xiang, H. Allayee, J. M. Lawrence, and T. A. Buchanan. "Genetics of Gestational Diabetes Mellitus and Type 2 Diabetes." Diabetes Care 30, Supplement 2 (2007): S134—S140. http://dx.doi.org/10.2337/dc07-s205.

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49

Vinall, M., and T. Frayling. "Human Genetics and Type 2 Diabetes: Behind the Headlines." MD Conference Express 12, no. 16 (2012): 30–31. http://dx.doi.org/10.1177/155989771216015.

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50

Elbein, Steven C. "Genetics Factors Contributing to Type 2 Diabetes across Ethnicities." Journal of Diabetes Science and Technology 3, no. 4 (2009): 685–89. http://dx.doi.org/10.1177/193229680900300412.

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