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Dissertations / Theses on the topic 'Type 2 type 2 diabetes'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Dow, Courtney. "Dietary Factors, Type 2 Diabetes and Diabetic Retinopathy." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS380/document.

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Contexte : Le diabète de type 2 (DT2) constitue une pathologie majeure, au lourd fardeau, associ ée à de nombreuses complications, comme la rétinopathie diabétique (RD). Des facteurs modifiables, comme l’alimentation, ont déjà été identifiés pour le DT2 et la RD mais certains aspects de leurs rôles restent à préciser. Objectifs : Les objectifs de cette thèse étaient d’examiner le rôle de l’alimentation, en particulier la consommation d’acides gras (AGs), et des autres facteurs modifiables liés au mode de vie sur le risque de DT2 et de synthétiser, interpréter et analyser la relation entre l’al

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2

Sundsten, Tea. "Protein Profiling and Type 2 Diabetes." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8458.

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<p>Type 2 diabetes mellitus (T2DM) is a heterogeneous disease affecting millions of people worldwide. Both genetic and environmental factors contribute to the pathogenesis. The disease is characterized by alterations in many genes and their products. Historically, genomic alterations have mainly been studied at the transcriptional level in diabetes research. However, transcriptional changes do not always lead to altered translation, which makes it important to measure changes at the protein level. Proteomic techniques offer the possibility of measuring multiple protein alterations simultaneous

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3

Scott, Sarah R. "The management of type 2 diabetes." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397095.

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4

Lindsay, J. R. "Glycated peptides in type 2 diabetes." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269002.

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5

Steven, Sarah. "The reversibility of type 2 diabetes." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3177.

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The incidence of both obesity and type 2 diabetes continues to rise, creating a major worldwide public health challenge. Understanding the mechanisms determining the normalisation of blood glucose levels and the limitations to complete reversal of diabetes by bariatric surgery or a very low calorie diet (VLCD) has important implications for the treatment of type 2 diabetes, but also for improving our understanding of the pathophysiology. A unifying hypothesis to explain the major pathophysiological changes in type 2 diabetes, hepatic insulin resistance and pancreatic beta cell insufficiency, i

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6

Li, Luosheng. "Molecular genetics of type 2 diabetes /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-194-2/.

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7

Praet, Stephan Florent Eugenie. "Exercise therapy in Type 2 diabetes." Maarsen : Maastricht : Elsevier gezondheidszorg ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=9387.

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8

Forbes, Shareen. "Catecholamine sensitivity preceding Type 2 diabetes." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425685.

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9

Gloyn, Anna Louise. "Molecular genetics of type 2 diabetes." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343364.

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10

Zhang, Yun. "Molecular genetics of type 2 diabetes." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298425.

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11

Pascoe, Laura. "Genetic determinants of Type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582170.

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Type 2 diabetes is a complex disease resulting from a combination of the inability of target cells to recognise and respond to insulin and a defect in the ability of the ~-cells to secrete insulin. Both genetic and environmental factors contribute to the risk, presentation and progression of the disease. Knowledge of the underlying architecture and mechanisms remain incomplete; however recent advancements in genotyping technology have allowed us to define potential type 2 diabetes genes through genome wide association (GWA) studies of very large populations, to compliment data from the more tr

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12

Hough, Alison Janette. "Mouse models of type 2 diabetes." Thesis, Oxford Brookes University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520928.

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13

Patel, Pushpa. "Molecular genetics of Type 2 diabetes." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314843.

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14

Wilmot, Emma Gwyn. "Type 2 diabetes in younger adults." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/27976.

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Background: The rising prevalence of obesity and sedentary behaviour has lead to a substantial increase in the number of younger adults (<45 years) developing Type 2 diabetes (T2DM). The amount of time spent sitting (sedentary) has been identified as a risk factor for T2DM which, if targeted, has the potential to prevent T2DM. Aims: 1) To extensively phenotype younger adults with T2DM; 2) To conduct a systematic review and meta-analysis to investigate the relationship between sedentary time, T2DM, cardiovascular disease, cardiovascular and all-cause mortality; 3) To develop the Sedentary Time

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15

Travers, Mary E. "Mechanisms of Type 2 diabetes susceptibility." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d99892d8-534a-4908-b5dc-ab1d8b1cab52.

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Type 2 diabetes (T2D) has a genetic component which is only partially understood. The majority of genetic variance in disease susceptibility is unaccounted for, whilst the precise transcripts and molecular mechanisms through which most risk variants exert their effect is unclear. A complete understanding of T2D susceptibility mechanisms could have benefits in risk prediction, and in drug discovery through the identification of novel therapeutic targets. Work presented in this thesis aims to define relevant transcripts and disease mechanisms at known susceptibility loci, and to identify disease

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16

Weedon, M. N. "Molecular genetics of type 2 diabetes." Thesis, Exeter and Plymouth Peninsula Medical School, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701317.

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17

Ryysy, Leena. "Insulin treatment in type 2 diabetes." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/ryysy/.

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18

Simonen, Piia. "Cholesterol metabolism in type 2 diabetes." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/simonen/.

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19

Ikpeama, Blessing Nneoma. "Telehealth and Type 2 Diabetes Management." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6907.

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The use of telehealth in healthcare has grown in recent years; however, little is known about the effectiveness of this delivery method in the management of Type 2 diabetes mellitus (T2DM). Guided by the chronic care model and telehealth in chronic disease model, the purpose of this systematic literature review was to explore evidence related to lowering hemoglobin A1c levels and managing T2DM using telehealth in the outpatient setting. The practice-focused questions explored telehealth interventions used in T2DM management and their effectiveness. The Joanna Briggs Institute (JBI) method for

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20

Sudagani, Jaidev. "Genes and type 2 diabetes : polymorphisms of the EIF2AK3 gene and its relationship to type 2 diabetes mellitus." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/411.

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Aims/ Hypothesis: Wolcott- Rallison syndrome (WRS) is a rare autosomal recessively inherited Mendelian disorder. It is characterised by a short trunk compared to arm span, multiple epiphyseal dysplasia, multiple fractures, hepatosplenomegaly and renal insufficiency in addition to insulin dependent diabetes. The onset of diabetes in WRS families is mainly below the age of 6 months and is characterised by permanent severe non-autoimmune insulin deficiency. Mutations of the gene encoding eukaryotic translational initiation factor 2 - alpha kinase 3 (EIF2AK3) were found to account for diabetes in

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21

Stavrou, Eftyhia P. "Functional losses in type 2 diabetes mellitus." Thesis, Queensland University of Technology, 2001. https://eprints.qut.edu.au/36771/1/36771_Digitised%20Thesis.pdf.

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Aims: Psychophysical tests such as Letter contrast sensitivity (CS) and flicker perimetry have been used to detect early functional losses in ocular disease such as age-related maculopathy (ARM) and in vascular disorders such as migraine. This study set out to determine the ability of these tests to detect early functional losses in type 2 diabetics with minimal or early diabetic retinopathy (DR). Methods: Subjects consisted of 20 patients with type 2 diabetes (duration, following diagnosis, ranging from 6 months to 18 years) and 24 age-matched normal controls. Letter CS, using t

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22

Carey, Peter Edward. "Post prandial metabolism in type 2 diabetes." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430693.

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23

West, Sophie Diana. "Obstructive sleep apnoea and type 2 diabetes." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29539.

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Aims: To establish the prevalence of OSA in individuals with type 2 diabetes, and whether treatment with CPAP improves glycaemic control and insulin resistance. Methods and Results: A questionnaire was sent to 1682 men with type 2 diabetes from hospital and primary care databases. Fifty-six percent replied; 57% scored as 'high' and 39% as 'low' risk for OSA; 4% had known OSA. Overnight oximetry in 240 respondents from the 'high' and 'low' risk groups showed 31% and 13% respectively had significant OSA, verified by sleep studies. Exploration and oximetry data to the questionnaire respondent pop

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24

Wolffenbuttel, Bruce Herbert Ralph. "Type 2 diabetes mellitus pathology and treatment /." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1991. http://arno.unimaas.nl/show.cgi?fid=5673.

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25

Lim, Ee Lin. "Unravelling the pathogenesis of type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1507.

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Type 2 diabetes has become a worldwide epidemic. It is characterised by insulin resistance in major metabolic tissues, and failure of β-pancreatic cells to compensate for this abnormality. Insulin resistance is recognised as an early event in the pathogenesis of type 2 diabetes. Although the precise factors that lead to insulin resistance have not been elucidated fully, there is strong association between insulin resistance and lipid accumulation, in particular lipotoxic fatty acid metabolites in insulin-target tissues. Most recently, evidence has been presented to link abnormal fatty acid acc

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26

Elston, Lucinda Mary. "Exercise, the microcirculation and type 2 diabetes." Thesis, University of Exeter, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409025.

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27

Фадєєва, Ганна Анатоліївна, Анна Анатольевна Фадеева, Hanna Anatoliivna Fadieieva, and A. Albert. "Cancer risk due to type 2 diabetes." Thesis, Sumy state university, 2017. http://essuir.sumdu.edu.ua/handle/123456789/54963.

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Epidemiologic studies show that type 2 diabetes increases the risk of certain cancers. Different antidiabetic drugs used for the treatment of type 2 diabetes can modify cancer risk. Study objectives: to evaluate risk factors common to both diabetes and cancer.

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28

Shotckaia, Anastasiia. "Deprived neighbourhoods, borders and type 2 diabetes." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-22945.

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29

Eason, Robert C. "Treating type 2 diabetes through insulin resistance." Thesis, Aston University, 2002. http://publications.aston.ac.uk/10953/.

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Type 2 diabetes is an insidious disorder, with micro and/or macrovascular and nervous damage occurring in many patients before diagnosis. This damage is caused by hyperglycaemia and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor for type 2 diabetes. Skeletal muscle is the main site of insulin-stimulated glucose disposal and appears to be the first organ that becomes insulin resistant in the diabetic state, with later involvement of adipose tissue and the liver. This study has investigated the use of novel agents to ameliorate

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30

Andrews, Robert. "Cortisol metabolism in type 2 diabetes mellitus." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/23073.

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In chapter 2, I describe my first study, which determined whether individuals with DMA or impaired glucose tolerance (IGT) exhibit abnormalities in cortisol activity. An integrated assessment of cortisol secretion, metabolism and action was carried out in 25 un-medicated lean male patients with hyperglycaemia (20 DM and 5 IGT) and 25 healthy controls carefully matched for body mass index, age and blood pressure. This study demonstrated that patients do exhibit abnormalities in cortisol activity. Chapter 3 describes a study that examined whether altered tissue concentration of the glucocorticoi

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31

De, Groot Julia A. "An Analysis of Type 2 Diabetes Interventions." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415269.

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Background Type 2 diabetes is a type of chronic and progressive metabolic disorder characterized by persistent hyperglycaemia. It is associated with numerous complications, a high burden of disease, and large economic costs. This thesis intends to explore the existing knowledge about current and emerging interventions for type 2 diabetes, aiming to identify and fill in some of the current gaps in the literature. Currently, telemedicine has become increasingly popular as a convenient and cost-saving method of intervention. However, in-depth analysis of telemedicine for various health outcomes a

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32

Dille, Renee. "Serum Uric Acid and Type 2 Diabetes." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281174.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Objectives: In recent years, serum uric acid has emerged as a possible risk factor for type 2 diabetes mellitus (T2DM). It remains unclear if this is independent of other well-known risk factors related to the metabolic syndrome. This retrospective epidemiologic study attempts to clarify the relationship between uric acid and T2DM, as well as to assess uric acid as a predictor for future diabetes development. Methods: Data was collec

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33

Saker, Philip John. "The molecular genetics of Type 2 diabetes." Thesis, Open University, 1995. http://oro.open.ac.uk/57565/.

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Type 2 diabetes has a substantial genetic component. The aim of this dissertation was to investigate the molecular basis of Type 2 diabetes with particular emphasis on the role of the glucokinase gene. Other work studied specific mutations in the tRNALeu(UUR) gene of mitochondrial DNA and in the glucagon receptor gene. The Introductory chapter presents an overview of Type 2 diabetes, and the influence of the environment and the contribution of genetics to its development. It then introduces the molecular biological approach to the study of this disease and the function of the J3-cell and the i

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34

Fort, Fachecia L. "Type 2 Diabetes Management for Geriatric Veterans." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5462.

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Managing diabetes in the geriatric long-term care population can be challenging, yet important because diabetes is a chronic, progressive disease. The purpose of this project was to identify clinical practice guidelines for managing Type 2 diabetes in geriatric veterans and to develop a class to educate providers on diabetes management in the geriatric long-term care population at a community living and rehabilitation center. The practice focused question asked if providing education to providers about the clinical practice guidelines for managing Type 2 diabetes in geriatric long-term care ve

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35

White, Kathryn Elizabeth. "Glomerular structure and function in type 1 and type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394642.

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36

Dann, Fiona. "Type 2 diabetes and depression : an exploration into the most effective depression screen to be used in a type 2 diabetes population /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18463.pdf.

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37

Espelt, Hernández Albert 1981. "Socioeconomic inequalities in type 2 diabetes mellitus in Europe." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/85055.

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Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide. The St. Vincent declaration emphasized the urgent need to improve the epidemiological knowledge of this disease in Europe. Within Europe, research on the link between socioeconomic position (SEP) and type 2 diabetes is scarce. The objective of this thesis was to conduct an extensive review of the current literature on socioeconomic inequalities in type 2 diabetes within European countries, while analyzing the relationship between, incidence, prevalence and mortality due to T2DM and SEP. In addition, we also analyzed

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38

Morling, Joanne Rebecca. "The epidemiology of chronic liver disease in older people with type 2 diabetes mellitus : the Edinburgh Type 2 Diabetes Study." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21101.

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Increasingly chronic liver disease is being acknowledged as a complication of type 2 diabetes, in particular non-alcoholic fatty liver and non-alcoholic fatty liver disease. Rates of non-alcoholic fatty liver are higher in people with type 2 diabetes than in the general population, with prevalence rates believed to be between 40-70%. Given the aging Scottish population and the obesity driven diabetes epidemic, the problem of chronic liver disease is likely to increase. Despite this there has been little investigation into the natural history of nonalcoholic fatty liver disease and the risks of

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39

Santos, Anabela Gonçalves dos. "Mapeando pés: prevenir lesões nos pés de utentes com diabetes tipo 2." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Saúde, 2019. http://hdl.handle.net/10400.26/28809.

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Mestrado em Enfermagem, Área de especialização: Enfermagem Comunitária e de Saúde Pública<br>Introdução: O défice na gestão da Diabetes Mellitus propicia o aparecimento de complicações tardias. O Pé Diabético é uma das mais frequentes e graves. Objetivo: Capacitar para a promoção do autocuidado das pessoas com Diabetes tipo 2, relativamente ao risco de úlcera de pé diabético. Método: Com base na Metodologia do Planeamento em Saúde, foi desenvolvido um projeto de intervenção comunitária, dirigido a pessoas com diabetes tipo 2. Foi aplicado um questionário aos utentes com diabetes e realizada

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40

Mathur, Aditi. "Genetic association between schizophrenia and type-2 diabetes." Thesis, University of the Highlands and Islands, 2011. https://pure.uhi.ac.uk/portal/en/studentthesis/genetic-association-between-schizophrenia-and-type2-diabetes(71a1d702-37b0-470d-87d9-956cbd52c821).html.

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Aims: This PhD project was designed under two studies, the genetic association study to investigate a genetic component or a genetic pathway that might be associated with both schizophrenia and type-2 diabetes (T2D). The gene functional study to explore whether clozapine could affect expression of the genes associated with obesity and T2D. Methods: In genetic association study, a total of 17 single nucleotide polymorphisms (SNPs) were genotyped in the PPARG, PLA2G4A, PTGS2 and AKT1 genes in 221 British nuclear families. In the gene functional study, U937 cells were treated with clozapine (1g/

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41

Macrodimitris, Sophia D. "Coping, control, and adjustment in type 2 diabetes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39211.pdf.

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42

Zhou, Huali. "Reverse cholesterol transport in type 2 diabetes mellitus." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39794003.

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43

Cook, Joanne. "Genetic and environmental contributions to type 2 diabetes." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306218.

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44

Balasubramanian, Ravikumar. "Postprandial metabolism in health and type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500958.

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hisulin resistance is a characteristic halhnark of type 2 diabetes and contributes to impaked glucose disposal and utilization in insulin-sensitive tissues (liver, skeletal muscle and fat) and inadequate suppression of postprandial hyperglycaemia. Elevated hepatic and intramuscular triglyceride (TG) content in type 2 diabetes has been postulated to underpin the insulin resistance seen in each of these issues. The reasons for this increased tissue TG content is poorly understood. Reduction in liver TG content with weight loss normalizes basal rates of EGP. Likewise peroxisome proliferator activ

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45

Mathur, Aditi. "Genetic associaton between schizophrenia & type-2 diabetes." Thesis, University of Aberdeen, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542850.

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Methods: In a genetic association study, 17 single nucleotide polymorphisms (SNPs) were genotyped in the <i>PPARG, PLA2G4A, PTGS2 </i>and <i>AKT1</i> genes in 221 British nuclear families. In the gene functional study, U937 cells were treated with clozapine (1μg/ml and 2μg/ml) for 48 hours and 96 hours. Quantitative real-time PCR analysis was used to measure the mRNA expression levels of the genes of interest in clozapine-treated and untreated cells. Results: Eight SNPs tested across the <i>PPARG</i> gene did not show allelic association with schizophrenia. An association was detected at rs274

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46

Zhou, Huali, and 周華麗. "Reverse cholesterol transport in type 2 diabetes mellitus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39794003.

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47

Hull, Rebecca L. "Pro-islet amyloid polypeptide and type 2 diabetes." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285837.

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48

Advani, Andrew. "The blood cell cytoskeleton in type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289211.

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49

Lawson, Nicola L. "Targeting PDX1 gene transcription in type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424041.

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Shepherd, Louisa Margaret Anne. "Targeting IAPP gene transcription in type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413952.

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