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Dissertations / Theses on the topic 'Types of uterine leiomyoma'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Uimari, O. (Outi). "Epidemiological and familial risk factors of uterine leiomyoma development." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526214870.

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Abstract Uterine leiomyomas are the most common benign tumours in females. They are myometrial neoplasms, may present single or multiple, and may be located in various sites of the uterus. Leiomyomas distort the uterine cavity and the uterus itself, causing abnormal vaginal bleeding, reduced fertility and also pelvic pressure and pain symptoms. The aim of this study was to elaborate current knowledge on familial uterine leiomyomas and to explore the possible association between uterine leiomyoma and cardiovascular disease risk factors, and also the association between leiomyomas and endometrio

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2

Wu, Xuxia. "Molecular mechanisms involved in the growth of human uterine leiomyomas /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-369-4/.

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3

Barbosa, Lígia Flávia da Silva. "Epidemiological factors associated with uterine fibroids." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1066.

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Introduction: The uterine fibroids are the most common benign neoplasm in the female genital tract. However, the prevalence of this disease in the general population is unknown, which justifies this investigation. Objective: To evaluate epidemiological factors associated with uterine myomas, in a setting of a private medical clinic. Methodology: It is presented as a cross-sectional research, drafted with a descriptive and an analytical component. To collect data a routine demographic computerized file was kept for every patient and a pelvic transvaginal or transrectal ultrasonography w

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4

Janjusevic, Milijana. "Raf kinase inhibitor protein (RKIP) expression and function in uterine leiomyoma." Doctoral thesis, Università Politecnica delle Marche, 2016. http://hdl.handle.net/11566/243082.

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I leiomiomi uterini (detti anche fibromi, miomi) sono tumori benigni che originano dallo strato muscolare dell’utero (miometrio) e rappresentano la principale indicazione dell’isterectomia nel mondo. I leiomiomi uterini colpiscono circa il 77% delle donne in eta fertile e circa il 25% di esse presenta tumori con sintomatologia clinica evidente, tra cui la presenza di forte o anomalo sanguinamento uterino, dolore o pressione pelvica, infertilità e aborti ricorrenti. È comunemente noto che questi tumori sono caratterizzati da una elevata proliferazione cellulare ed una eccessiva deposizione

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5

Protic, Olga. "Involvement of Inflammation and Activin A in Pathogenesis of Uterine Leiomyoma." Doctoral thesis, Università Politecnica delle Marche, 2015. http://hdl.handle.net/11566/243008.

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I leiomiomi (fibromi) uterini sono neoplasie benigne estremamente comuni. L’incidenza è di oltre il 60% in donne in età fertile e pertanto, rappresentano uno dei maggiori problemi di sanità pubblica. I leiomiomi sono spesso multipli, originano nello strato muscolare dell’utero, e si ritiene che ogni fibroma origina da una singola cellula trasformata. Sebbene si sta iniziando a comprende la patofisiologia dei leiomioma, la loro origine resta sconosciuta. Negli ultimi anni, i ricercatori hanno considerato i leiomiomi come una patologia fibrotica. La fibrosi è un processo continuo ed esagerato di

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6

GRECO, STEFANIA. "The effect of Phytochemical Compounds on Uterine Myometrial and Leiomyoma Cells." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263604.

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Il fibroma uterino o leiomioma è il tumore benigno più comune che colpisce l’utero nelle donne in età fertile. I fibromi causano, dolore o pressione pelvica, menorragia ossia una perdita ematica mestruale abbondante nonché dolorosa, ed è una delle principali cause d’infertilità e aborti ricorrenti. I fibromi uterini, sono l’indicazione principale d’isterectomia. Nonostante, l'alta prevalenza di questa patologia nelle donne, la patogenesi dei leiomiomi uterini non è stata ancora del tutto chiarita. Recenti studi, hanno dimostrato che una dieta basata su composti fitochimici ha proprietà pr

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7

OKAMOTO, TOMOMITSU, SHIGEKO SAITO, SHIHO TANAKA, SACHI NAGAI, YUKIKO MORI, and MAI HORIKAWA. "METASTATIC BREAST CANCER TO THE UTERINE CERVIX MIMICKING A GIANT CERVICAL LEIOMYOMA." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16745.

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8

Burroughs, Kevin Dale. "The role of ovarian hormones in the development and growth of uterine leiomyoma /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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9

Chan, Arthur Ho-Yin. "Image-guided high intensity focused ultrasound treatment for uterine leiomyomata /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8068.

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10

Patel, Trusher. "Uterine Arterial Embolization: Classification of Leiomyomas to Determine Predictors of Response." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-134426/.

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The purpose of this study is to determine features of uterine leiomyoma on Magnetic Resonance Imaging (MRI) that identify predictors of response to Uterine Arterial Embolization (UAE). MRI images were obtained before and after UAE in 35 women. These images were analyzed for uterine and fibroid size changes along with fibroid border characteristics and location for a total of 73 fibroids. Fibroids were classified as either smooth or lobulated based on border appearance on MR imaging to determine any differences in mean fibroid volume reduction post-embolization. The mean decrease in fibroid vol

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11

Карпенко, Людмила Іванівна, Людмила Ивановна Карпенко, Liudmyla Ivanivna Karpenko та Е. В. Выходцева. "Гистологические изменения эндометрия при лейомиоме у работниц промышленного предприятия". Thesis, Издательство СумГУ, 1997. http://essuir.sumdu.edu.ua/handle/123456789/24779.

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12

Савченко, І. М. "Аналіз впливу однонуклеотидного поліморфізму С-1562Т гена ММР-9 на розвиток лейоміоми матки у жінок, що мають кістозно змінені яєчники". Thesis, Сумський державний університет, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41401.

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Пошук нових біологічних маркерів раннього прогнозу розвитку доброякісних пухлинних процесів в матці сьогодні залишається актуальним, адже з приводу лейоміоми матки (ЛМ) виконується більшість гінекологічних операцій. Перебіг лейоміоми матки часто поєднується зі змінами з боку яєчників. Утворення кіст та кістом яєчників нерідко ускладнюють дифдіагностику з пухлинними процесами матки.

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13

Савченко, І. М. "Гени-кандидати механізмів розвитку доброякісних пухлин матки". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32932.

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Лейоміома матки (ЛМ) – це доброякісна пухлина, яка росте з незрілих міоцитів судинної стінки матки і займає перше місце серед доброякісних пухлин статевих органів. З приводу ЛМ виконується до 50-70% оперативних втручань в гінекологічних стаціонарах, з яких 60,9-95,5% приходиться на радикальні операції, в тому числі і в репродуктивному віці (24-26,8%) ще у зовсім юних жінок, які не встигли реалізувати свою репродуктивну функцію, що визначає соціальну значимість данної патології. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32932

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14

INGRAHAM, SUSAN ELIZABETH. "THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029433658.

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15

CASTELLUCCI, CLARA FEDERICA. "Ability of omega-3 fatty acids to modulate uterine fibrotic cell structure and gene expression." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/256439.

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I leiomiomi uterini, anche conosciuti come fibromi, rappresentano la forma tumorale benigna più comune nelle donne fertili. Spesso si ricorre all’asportazione chirurgica dell’utero, isteroctomia, con conseguente morbilità e onere socioeconomico. La patogenesi non è del tutto conosciuta, pertanto è auspicabile una migliore comprensione della malattia per definire nuovi bersagli terapeutici. In questo studio, abbiamo analizzato gli effetti degli acidi grassi omega-3 sul profilo lipidico, sull'architettura della membrana cellulare e sull'espressione di specifici geni nelle cellule isolate da mi

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16

Сумцов, Георгій Олексійович, Георгий Алексеевич Сумцов, Heorhii Oleksiiovych Sumtsov, Дмитро Георгійович Сумцов, Дмитрий Георгиевич Сумцов та Dmytro Heorhiiovych Sumtsov. "Щадящие операции у молодых женщин". Thesis, Издательтво СумГУ, 2009. http://essuir.sumdu.edu.ua/handle/123456789/5738.

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17

Тарасов, К. М., О. В. Бургело та О. С. Решетнікова. "Патоморфологічні особливості плацент у жінок з вагітністю ускладненою лейоміомою матки". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/26896.

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18

Bredhult, Carolina. "Effects of some Endocrine Disruptors on Human and Grey Seal Uterine Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8334.

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19

Arponen, Felicia. "Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-94171.

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Bakgrund: Myom är den vanligaste gynekologiska benigna tumören hos kvinnor i fertil ålder. Det finns idag läkemedelsbehandlingar, invasiva ingrepp och icke-invasiva ingrepp vid behandling av myom. Utvecklingen av läkemedel mot myom är lågprioriterat, eftersom de främst är benigna och snarare leder till sjuklighet än dödlighet. De läkemedel som idag används vid behandling av myom är ulipristal, GnRH-agonister, NSAID, tranexamsyra, p-piller eller hormonspiral. Ulipristal och GnRH-agonister har utöver förbättring av symtom som alla de senast nämnda, en effekt på reducering av myomstorlek. Icke-in

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20

Савченко, І. М. "Асоціація однонуклеотидного поліморфізму С-1562Т гена ММР-9 із хронічними сальпігоофоритами у жінок із лейоміомою матки". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45044.

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Актуальність. Перебіг лейоміоми матки часто поєднується зі змінами запального характеру з боку маткових труб та яєчників - сальпінгоофоритами. Утворення гідро- та піосальпінксів нерідко ускладнюють дифдіагностику з пухлинними процесами матки. В патогенезі ЛМ поруч з гормональними порушеннями та факторами росту, ключове значення має склад позаклітинних компонентів сполучної тканини – т. зв. матрикс. Від його стану і характеристик багато в чому залежить поведінка пухлинних клітин: На властивості матриксу істотним чином впливають ферменти матриксні металопротеїнази, здатні розщеплювати різні комп

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21

Сухарєв, Анатолій Борисович, Анатолий Борисович Сухарев та Anatolii Borysovych Sukhariev. "Современная гормональная терапия лейомиомы матки". Thesis, Издательство СумГУ, 1997. http://essuir.sumdu.edu.ua/handle/123456789/24732.

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22

Бургело, О. В., та О. С. Решетнікова. "Морфологічні особливості будови лейоміом матки при вагітності". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/26876.

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Згідно даних численних публікацій серед захворювань у жінок репродуктивного віку, лейоміома матки займає друге місце в структурі гінекологічної патології. Лейоміома матки – це доброякісна, добре обмежена інкапсульована пухлина, джерелом розвитку якої є гладком'язові клітини шийки або тіла матки. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/26876

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23

Sant'Anna, Gabriela dos Santos. "Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/169713.

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Introdução: Leiomiomas uterinos ou miomas são tumores benignos que se desenvolvem no miométrio e acometem cerca de 50% da população feminina. Têm como principais sintomas, sangramento excessivo e dor pélvica inespecífica. Convencionalmente o estrogênio é considerado o responsável pelo início da proliferação tumoral, mas recentes evidências clínicas e bioquímicas sugerem que a progesterona apresenta um papel importante no desenvolvimento desses tumores. Além disso, mecanismos epigenéticos parecem estar envolvidos na etiologia dos leiomiomas uterinos, como a metilação de DNA e acetilação de hist

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24

Zlotnik, Eduardo. "Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11092012-095441/.

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Os métodos minimamente invasivos têm sido cada vez mais utilizados para o tratamento do leiomioma e, a embolização da artéria uterina, tem se destacado como método seguro e efetivo. O objetivo deste estudo foi avaliar, pela ressonância magnética da pelve, os fatores preditores da diminuição dos leiomiomas de pacientes submetidos a embolização da artéria uterina. Métodos: Estudaram-se 50 mulheres sintomáticas com leiomioma uterino, na menacme, que foram submetidas a embolização da artéria uterina. Acompanhou-se, por meio da ressonância magnética o volume do útero e dos leiomiomas. Foram examina

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25

Савченко, Інна Миколаївна, Инна Николаевна Савченко та Inna Mykolaivna Savchenko. "Зв'язок поліморфізму генів матриксних металопротеїназ з факторами ризику та механізмами розвитку лейоміоми матки". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47369.

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За допомогою полімеразної ланцюгової реакції з наступним аналізом довжини рестрикційних фрагментів визначено частоту алелів і розподіл генотипів за поліморфізмами 1G/2G-1607 гена MMP-1 і C-1562T гена MMP-9 у пацієнток з лейоміомою матки і жінок контрольної групи. Встановлено асоціацію першого поліморфізму з доброякісною пухлиною. Ризик її розвитку в гомозигот за 2G-алелем у 3,2 раза вищий, ніж у гомозигот за алелем 1G. Загальні фактори ризику (наявність пухлин у близьких родичів і факторів атерогенезу: артеріальної гіпертензії, цукрового діабету), а також репродуктивно-гінекологічний статус

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Lott, Daniela Alves Malzone. "Validação e tradução cultural do questionário UFS-QOL para a língua portuguesa." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-07062017-100427/.

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O leiomioma uterino é o tumor ginecológico mais comum na mulher, causando principalmente sangramento uterino anormal e dor pélvica. Existe apenas um questionário que avalia a qualidade de vida de mulheres com esta doença, o Uterine Fibroid Symptom and Quality of Life (UFS-QOL), porém somente na língua inglesa. Dessa forma, objetivamos traduzir e validar culturalmente o questionário UFS-QOL para mulheres brasileiras. Realizamos um estudo transversal no Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo. Cento e treze pacientes porta

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Hilário, Sandro Garcia. "Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09082012-164244/.

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OBJETIVO: Avaliar a receptividade endometrial de pacientes submetidas à embolização do mioma uterino, analisando a expressão gênica de LIF, IL-11, IL-6, claudina-4, HoxA-10, HoxA-11, receptor de estrogênio e receptor de progesterona antes e após este procedimento. CASUÍSTICA E MÉTODOS: Foram colhidas biópsias aspirativas de endométrio de 30 pacientes previamente à embolização do mioma uterino e repetida a coleta 3 a 4 meses após este procedimento. A média etária do grupo estudado foi de 36,2 anos. O volume uterino médio pré-embolização foi de 662,1 cc e o pós-embolização foi de 338,2 cc, medid

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28

CAFFARINI, MIRIAM. "Mesoderm stem cells and inflammation: role in the Pathogenesis and potential therapy of selected Gynecological Deseases and primary Myopathies." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263543.

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Le cellule staminali mesenchimali (MSCs) sono un tipo specifico di cellule staminali adulte con un elevato potenziale proliferativo e differenziativo verso cellule specializzate di derivazione mesodermica. Le MSCs svolgono anche una funzione paracrina attraverso il rilascio di molteplici fattori di crescita, chemochine e citochine. Le MSCs si comportanto da sentinelle che percepiscono il microambiente e agiscono di conseguenza, passando da un fenotipo pro-infiammatorio ad uno immunosoppressivo in base ai segnali che ricevono. Nel seguente lavoro sono valutati l’esistenza e il ruolo delle MSCs

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Violet, Pierre-Christian. "Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00788479.

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Le léiomyome utérin est la pathologie utérine la plus fréquente chez les femmes en âges de procréer. Des résultats précédent obtenus avec les cellules ELT3, une lignée de cellules de léiomyomes de rat, ont montré que l'acide lysophosphatidique (LPA) activait les MAP kinases ERK1/2 via le récepteur LPA1 couplé à la protéine Gi et l'activation de Raf, Ras et de MEK. Durant ce travail, nous avons caractérisé l'activité phosphatase responsable de la dégradation du LPA dans cette lignée de cellules ELT3. Nous avons montré que le LPA était dégradé exclusivement par la lipide-phosphate phosphatase 1

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30

Queirós, Ana Cristina Alves. "Gene discovery in uterine leiomyoma using cytogenetic approaches." Master's thesis, 2009. http://hdl.handle.net/10451/1443.

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Tese de mestrado, Biologia (Biologia Humana e Ambiente), 2009, Universidade de Lisboa, Faculdade de Ciências<br>Uterine Leiomyoma (UL) are the most common benign neoplasm present in women of reproductive age, with approximately 40% of these tumors showing structural cytogenetic abnormalities. Implementation of cytogenetic analysis has been fundamental in gene discovery efforts in these tumors. Here, we report the molecular cytogenetic analysis of four uncommon UL abnormalities: 1) 46,X,-X,t(6;16)(q12;q24),del(15)(q14q21),+mar, which includes disruption of CUX1, a known tumor suppressor/oncogen

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31

Cook, Elizabeth Donohoe. "Patterns of care for women with uterine leiomyoma." 2003. https://scholarworks.umass.edu/dissertations/AAI3096269.

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Leiomyomata uteri, also know as uterine fibroids, are the most common tumors of the female reproductive tract. Although the majority of leiomyomata are asymptomatic, more than 30% of affected women suffer from one or more symptoms including abnormal uterine bleeding, anemia, pelvic pain, pelvic pressure, urinary problems and infertility. Our objective was to identify patient-, physician- and hospital-related factors that are associated with patterns of care for this condition. Two approaches were used to identify determinants of treatment among women with a primary diagnosis of leiomyoma. Firs

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32

shih-chieh, Lin, and 林世杰. "Expression of Pituitary Tumor Transforming Gene-1(PTTG1) in Uterine Leiomyoma." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/40230267482793444014.

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碩士<br>國立成功大學<br>生理學研究所<br>92<br>Pituitary tumor transforming gene-1 (PTTG1), originally isolated from rat pituitary tumor cells, can transform cells in vitro and is tumorigenic in vivo. It also serves as a regulator of mitosis and regulates secretion of fibroblast growth factor-2 (FGF2) that in turn stimulates PTTG1 expression. Uterine leiomyoma, derived from myometrium, is the most common benign uterine tumor in women. Although the cause of leiomyoma is still unclear, substantial evidences have shown that the growth of tumor is affected by ovarian hormones and growth factors. To investigate t

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"Molecular characterization of immortalized human uterine leiomyoma cell lines: A fibroid model." Tulane University, 2006.

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Human uterine leiomyomas (also known as fibroids, or myomas) are the most common benign tumors in women of reproductive age, affecting approximately 33% of all women and an estimated 77% of African American women. In the United States approximately 600,000 hysterectomies are performed annually at a cost of 1.7 billion dollars a year with fibroids accounting for 40% of procedures performed. Despite the high frequency of uterine leiomyomas and their major socioeconomic impact little research has been done in this area Many questions still remain to be answered concerning this disease. Therefore,

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Tung, Yen-Ting, and 董彥廷. "Melatonin inhibits the growth and abnormal deposition of extracellular matrix component in uterine leiomyoma cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/25495976367185256160.

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碩士<br>臺北醫學大學<br>保健營養學研究所<br>104<br>Women suffering from leiomyoma account for a quarter of the world''s female population. Study indicate that leiomyoma may be expand by estrogen imbalance, abnormal deposition of extracellular matrix and stem cell proliferation. Melatonin is an endogenous hormone produced by the pineal gland in the brain, can regulate physiological clock and secrete estrogen. In past studies, melatonin have antioxidant, anti-inflammatory, inhibit cancer cell growth and metastasis. In this study, we investigated the antitumor effect of melatonin on leiomyoma and smoot

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Kung, Hsiang-Lin, and 孔祥霖. "Inhibitory effects of isoliquiritigenin on estradiol-induced uterine leiomyoma proliferation in vitro and in vivo." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7w6ra5.

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"Immunohistochemical evaluation of growth factor and steroid receptors in uterine fibroid and normal myometrium." 1997. http://library.cuhk.edu.hk/record=b5889295.

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by Lai-pang Law.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1997.<br>Includes bibliographical references (leaves 148-182).<br>ABSTRACT<br>LIST OF ILLUSTRATIONS<br>LIST OF TABLES<br>ACKNOWLEDGEMENTS<br>ABBREVIATIONS<br>Chapter CHAPTER I --- INTRODUCTION --- p.1<br>Chapter CHAPTER II --- LITERATURE REVIEW --- p.4<br>Chapter 2.1 --- The uterus and its changes in the normal menstrual cycle<br>Chapter 2.2 --- Anatomy and physiology of normal myometrium<br>Chapter 2.3 --- Clinical features and management of uterine leiomyoma<br>Chapter 2.4 --- Pathology of human uterine leiomyoma<br>Cha

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Surtee, Fatima Zahra. "A descriptive study of uterine artery embolisation for leiomyoma in an African population in a low-resource setting." Thesis, 2015. http://hdl.handle.net/10539/23341.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Medicine in the branch of Obstetrics and Gynaecology MBBCh (Wits) Date: 22 September 2015<br>Introduction Uterine leiomyomas are the commonest benign tumours in women of reproductive age. Fibroids have a significant impact on the woman’s quality of life as well as her fertility. Women who have symptomatic fibroids can present with abnormal uterine bleeding, pressure symptoms, pain, infertility, miscarriage

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Yen, Yu-Ting, and 顏于婷. "The effects of adlay hull and testa ethanolic extracts on the uterine leiomyoma cells in vitro and in vivo." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/w6uuc6.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>103<br>Uterine leiomyomas are the most common benign tumors in women, with up to 20% of this population being clinically apparent. Patients with uterine leiomyomas often experience abnormal uterine bleeding, pelvic pain or pressure, infertility and recurrent pregnancy loss. Previous studies have shown adlay extract possesses anti-tumor activity and inhibit sarcoma cell proliferation and tumor progression. Many studies also confirmed that the methanol extracts of Adlay hull regulate the amount of estrogen and progesterone generate by inhibiting the activity of aromata

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Koomson, Jacqueline Nyarkoa. "The role of estrogen receptors alpha and beta in the development of uterine leiomyomas." Thesis, 2017. https://hdl.handle.net/2144/23835.

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Uterine leiomyomas are benign tumors within the uterus, where patients present with symptoms such as abnormal bleeding, urinary retention, and pelvic pressure. The exact etiology of uterine leiomyomas is unknown, but numerous theories have been proposed, indicating a multifactorial mechanism, including lifestyle and steroid hormones. Uterine leiomyomas have become a public health concern due to the high cost of treatment as well as the high prevalence within African American communities. Currently, many treatment options exist, ranging from conservative treatments that address symptoms, to sur

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"Differential epigenetic signatures between normal uterine smooth muscle cells (SMC) and leiomyoma cells (LM) and their association with estrogen responses." Tulane University, 2009.

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Differential gene expression between uterine leiomyoma (fibroids) and adjacent normal smooth muscle has been found in clinical tissues and cell cultures. The purpose of this study is to investigate whether there are differential epigenetic signatures and their involvement in differential gene expression, apoptosis and estrogen responses between two uterine stable cell lines, uterine leiomyoma UtLM-hT (LM) and normal uterine smooth muscle cell lines UtSM-hT (SMC). We first analyzed DNA methylation status using a cancer methylation panel bead array and our data showed that there are differential

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Lee, Pei Wen, and 李佩紋. "The assessment of quality of life and cost-effectiveness analysis on different treatment protocols for patients with endometriosis, adenomyosis, and uterine leiomyoma." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/59177302297019009546.

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碩士<br>長庚大學<br>醫務管理學系<br>101<br>Endometriosis, adenomyosis, and uterine leiomyoma are common chronic gynecologic diseases and all cause similar symptoms in which have negative impacts on all aspects of patient’s life including physiology, psychology, and economics. Besides, the managements of these diseases are all in similar ways including hysterectomy, local exicion, and medications. However, the effectiveness of any chozen treatment is varied due to patient’s characteristics. Therefore, this study aims to analyze the effectiveness, including relapse, complications, and quality of life, among

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Ramos, Ana Rita Roque Ribeiro de Andrade. "Miomas Uterinos: abordagem terapêutica atual e perspetivas futuras." Master's thesis, 2018. http://hdl.handle.net/10316/82145.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>O leiomioma uterino é um tumor ginecológico benigno frequente, atingindo 20-40% das mulheres em idade reprodutiva. Esta patologia associa-se a morbilidade significativa, afeta a qualidade de vida da mulher e representa a principal causa de histerectomia em Portugal. O presente artigo de revisão bibliográfica pretende analisar as atuais opções terapêuticas dos leiomiomas uterinos bem como as novas formas de tratamento médico que têm sido desenvolvidas. O tratamento médico tem como objetivo o controlo da sin

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Kubínová, Kristýna. "Určení frekvence mutací genu pro fumaráthydratázu u pacientek s děložními myomy." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-326181.

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Introduction: Uterine fibroids are the most common benign tumours of female genital tract with the peak incidence in the 4th and 5th decennium. The aetiology of uterine fibroids still remains poorly understood. Genetic factors play undisputed role in the onset of uterine fibroids. Up to date numerous gene mutations were identified in certain percentage of patients with uterine fibroids. One of the candidate genes is Fumarate hydratase gene (FH). Heterozygous germiline mutations of FH cause two hereditary syndromes: Multiple smooth muscle tumours of the skin and uterus (MCUL1)/ Hereditary leiom

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Lee, Wen-Ling, and 李文齡. "Comparison of Two Types of Uterine Vessel Occlusion in The Management of U Myomas:Focus on Therapeutic Outcome and Ovarian Function." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/31441411758698210553.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>98<br>Uterine leiomyomas (myomas, fibroids) are a most common disorder among women in the reproductive years (1). The majority of them are asymptomatic, and they are often detected incidentally in pelvic examination and/or ultrasound examination when women undergo routine preventive and/or physical examination. Since women with myomas are often asymptomatic, an expectant observation and follow-up is often recommended (2). Only the following conditions call for definite treatment: severe menstrual symptoms, pelvic pain, pressure complaints, subfertility, or pregnancy-

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Sosna, Ondřej. "Genový polymorfismus Th1/Th2 cytokinů u pacientek s děložní myomatózou." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-311446.

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Background: Uterine fibriod (UF) or leiomyoma is the most frequent benign tumour upon lower genital tract and represents the most frequent indication for hysterectomy. The aetiology remains still unknown. The genetic factors contributing for the development of UF are being intensively investigated. The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of UF. Methods: The study group enrolled 102 patients diagnosed with UF and 145 healthy controls. Ultrasonographic examination of the pelvis was p

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