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Journal articles on the topic 'Types of uterine leiomyoma'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Bura, Vlad, Roxana Maria Pintican, Reka Emma David, et al. "MRI findings in-between leiomyoma and leiomyosarcoma: a Rad-Path correlation of degenerated leiomyomas and variants." British Journal of Radiology 94, no. 1125 (2021): 20210283. http://dx.doi.org/10.1259/bjr.20210283.

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Leiomyomas are the most common benign tumors of the uterus. On the opposite side, leiomyosarcomas are rare malignant uterine tumors that account for a significant proportion of uterine cancer deaths. Especially when large and degenerated, leiomyomas and leiomyoma variants can have overlapping imaging characteristics with those of leiomyosarcomas. Although not always possible, it is paramount to be able to differentiate between leiomyomas and leiomyosarcomas on imaging, as the therapeutic management can differ. This pictorial review aims to familiarize radiologists with imaging features of leio

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2

Flaksenberg, M. A. "Morphological features of endo- and myometrium in patients with uterine leiomyoma and infertility." HEALTH OF WOMAN, no. 5-6(151-152) (July 30, 2020): 33–37. http://dx.doi.org/10.15574/hw.2020.151-152.33.

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The objective: determination of morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility to restore reproductive function and prevent recurrence of the underlying disease. Materials and methods. In order to restore reproductive function and prevent recurrence of the underlying disease, morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility were determined. Thirty samples of leiomyomatous nodes and endometrium were examined, among which 15 were obtained from women with multiple uterine le

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Tabbassam Naheed Kauser, Abdul Ghafoor, Mohammad Sajjad, Zubaida Khanum, Bushra Nabi, and Hina Khan. "Frequency and Histopathological variants of Leiomyoma in Uterine Specimens in a Tertiary Care Hospital." Journal of Saidu Medical College, Swat 11, no. 1 (2021): 9–13. http://dx.doi.org/10.52206/jsmc.2021.11.1.9-13.

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Background: Leiomyoma is the commonest benign smooth muscle tumor of uterus. It also occur in other organs like gall bladder,skin, gasterointestinal tract etc. Leiomyosarcoma is a rare malignant counter part of leiomyoma.Objective: To see the frequency of histopathological variants of leiomyomas in uterine specimens in Southern District ofKhyber Pakhtunkhwa Pakistan.Material and Methods: This descriptive study was conducted in Department of Pathology, Bannu Medical College Bannu incollaboration with Government and Private Hospitals of the Southern District of KPK. The duration of study was sev

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Yadav, Mehak, Parul Gupta, Vandana Agrawal, and Syed Sarfaraz Ali. "HISTOMORPHOLOGICAL SPECTRUM OF UTERINE LEIOMYOMA VARIANTS – A RETROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL." Era's Journal of Medical Research 9, no. 1 (2022): 15–24. http://dx.doi.org/10.24041/ejmr.2022.03.

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To study the histomorphological spectrum of uterine leiomyoma variants. This study is done over a period of three year (May 2019 to May 2022) in the Department of Pathology, LNMC, Bhopal. Total of 316 hysterectomy and 14 myomectomy specimens were studied. Specimens were fixed in formalin and paraffin embedded. H&E stained tissue sections were studied. In the study we performed retrospective analysis of hysterectomy and myomectomy specimen and 330 cases of leiomyoma were evaluated. Among 330 cases, 316(95.75%) were hysterectomy specimen for varying indication and 14(4.24%) were myomectomy s

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Hatirnaz, Safak, Sabri Colak, and Abdulkadir Reis. "Cystic Endometriosis in a Huge Degenerated Subserous Leiomyoma Mimicking Bilateral Multicystic Endometriomas in an Infertile Woman with Diminished Ovarian Reserve: A Rare Endometriotic Implantation." Case Reports in Obstetrics and Gynecology 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/2713943.

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Uterine leiomyomas are the most common pelvic tumor in women. Leiomyoma can show atypical locations and degenerations and may not be easily differentiated from adnexal masses. Uterine leiomyoma can undergo cystic degeneration and is said to be found in 4% of all types of degenerations. The commonest type of degeneration is hyaline seen in 60% of patients. Usually uterine leiomyoma does not present as clinical and radiological diagnostic challenge. However, when leiomyoma undergoes massive cystic degeneration they may become clinical and radiological diagnostic dilemmas. The MRI showed a huge c

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Askolskaya, S. I., O. R. Shablovsky, F. G. Zabozlaev, et al. "CLINICAL AND MORPHOLOGICAL OBSERVATION OF GIANT LEIOMYOMA AND UTERINE TUMORS OF CAHALE-LIKE CELLS." Journal of Clinical Practice 7, no. 1 (2016): 55–59. http://dx.doi.org/10.17816/clinpract7155-59.

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Tumors of the myometrium, reminiscent of leiomyoma with atypical location and aggressive growth, represent a diagnostic problem due to their common manifestations in various imaging techniques. These include various types of uterine leiomyomas, stromal endometrial tumors and rare tumors of cahal-like cells.

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7

A, Sivaranjani, Shobana B, Mary Lilly, and Jeev Prita. "Stromal Mystery with Cellular Secrets - Navigating Tumor Terrain: Insights into Endometrial Tumors." Journal of Neonatal Surgery 14, no. 5S (2025): 102–7. https://doi.org/10.52783/jns.v14.1991.

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Uterine smooth muscle tumors and endometrial stromal tumors (ESTs) are the two major types of mesenchymal tumors of the uterus, the latter being fairly uncommon. Among these, endometrial stromal sarcoma (ESS) accounts for less than 1% of all uterine tumours. Endometrial stromal tumors (ESTs) are rare uterine mesenchymal neoplasms and on occasion pose a diagnostic dilemma for pathologists if it coexists with leiomyomata.[1] According to the current WHO classification, they have been categorized into endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG‑ESS), high‑grade ESS, and

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A, Sivaranjani, Shobana B, Mary Lilly, Sai Sudha, and Jeev Prita. "Stromal Mystery with Cellular Secrets - Navigating Tumor Terrain: Insights Into Endometrial Tumors." Journal of Neonatal Surgery 14, no. 5S (2025): 263–69. https://doi.org/10.52783/jns.v14.2030.

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Uterine smooth muscle tumors and endometrial stromal tumors (ESTs) are the two major types of mesenchymal tumors of the uterus, the latter being fairly uncommon. Among these, endometrial stromal sarcoma (ESS) accounts for less than 1% of all uterine tumours. Endometrial stromal tumors (ESTs) are rare uterine mesenchymal neoplasms and on occasion pose a diagnostic dilemma for pathologists if it coexists with leiomyomata.[1] According to the current WHO classification, they have been categorized into endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG‑ESS), high‑grade ESS, and

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Armerinayanti, Ni Wayan, Desak Putu Oki Lestari, and I Gde Sastra Winata. "Specific Histologic Type of Leiomyoma Related to Estrogen Receptor Expression." WMJ (Warmadewa Medical Journal) 7, no. 2 (2022): 55–59. http://dx.doi.org/10.22225/wmj.7.2.4601.55-59.

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Uterine Leiomyoma or fibroid is the most common gynecologic benign neoplasm which arising from monoclonal proliferation of smooth muscle cells in uterine wall. Some specific types of uterine leiomyoma, such ascellular leiomyoma, symplastic leiomyoma, mitotically active leiomyoma andmyxoid leiomyomahave different histomorphology from usual type leiomyoma. It also have wide variety of tumors size, but this study found that no correlation between type of leiomyoma and its size. Additional non-invasive therapy that predominantly developed in leiomyoma include many antagonist agents of estrogenic r

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LEE, T. K., H. L. CHO, D. I. KIM, Y. C. LEE та C. H. KIM. "Scutellaria barbata D. Doninducesc-fosgene expression in human uterine leiomyomal cells by activating β2‐adrenergic receptors". International Journal of Gynecologic Cancer 14, № 3 (2004): 526–31. http://dx.doi.org/10.1136/ijgc-00009577-200405000-00016.

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Scutellaria barbata D. Don(Lamiaceae; SB) inhibited the growth of uterine leiomyomal (LM) cells with unknown actions. The expression patterns of β-adrenergic receptors (β-ARs) in human uterine LM cells and functional coupling to gene expression have also been investigated. Northern blot analysis showed that β-AR subtypes are expressed at different levels in the uterine LM cells and myometrial smooth muscle cells (SMCs). β1-AR expression was to be found approximately at the same level in the two cell types. β2-ARs were expressed at higher levels in uterine LM cells than that in myometrial SMCs.

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MEHEDINTU, Mihai, Razvan DANCIU, Alexandra CHELARIU, Andrei S. COMAN, and Cristian R. JECAN. "Cutaneous Leiomyomatosis – Case Report and Literature Review." Medicina Moderna - Modern Medicine 27, no. 3 (2020): 241–44. http://dx.doi.org/10.31689/rmm.2020.27.3.241.

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Cutaneous leiomyomas are uncommon benign smooth muscle tumors that comprise of three distinct types such as piloleiomyoma, angioleiomyoma, and genital leiomyoma. The discovery in 2001 of the association between cutaneous leiomyomas, uterine leiomyomas in women, and an aggressive form of renal cell cancer (RCC) underscores the importance of accurate dermatologic diagnosis of CL so that appropriate cancer screening and counseling of patients and at-risk relatives can be instituted. The present case report will discuss the pathogenesis, clinical manifestations, diagnosis, and management of a pilo

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О.V., Golyanovskiy, Kachur O.Yu., Budchenko M.А., Supruniuk K.V., and Frolov S.V. "Uterine leiomyoma: modern aspects of clinic, diagnosis and treatment." Reproductive Health of Woman 5 (June 30, 2021): 7–18. https://doi.org/10.30841/2708-8731.5.2021.240017.

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According to the WHO, neoplastic processes of the uterus remain one of the important and relevant areas of modern gynecology. Uterine leiomyoma is one of the most common tumors of the female reproductive system. According to the latest data, every 4–5th woman in the world is diagnosed with leiomyoma, the incidence of which under the age of 35 reaches 50%, and according to autopsy data reaches 80%. The article provides a review of the scientific publications in recent years devoted to the study of the problem of uterine fibroids – relevance, causes and mechanisms of development, pro

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Golyanovskiy, О. V., O. Yu Kachur, M. А. Budchenko, K. V. Supruniuk, and S. V. Frolov. "Uterine leiomyoma: modern aspects of clinic, diagnosis and treatment." Reproductive health of woman 5 (June 30, 2021): 7–18. http://dx.doi.org/10.30841/2708-8731.5.2021.240017.

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According to the WHO, neoplastic processes of the uterus remain one of the important and relevant areas of modern gynecology. Uterine leiomyoma is one of the most common tumors of the female reproductive system. According to the latest data, every 4–5th woman in the world is diagnosed with leiomyoma, the incidence of which under the age of 35 reaches 50%, and according to autopsy data reaches 80%.The article provides a review of the scientific publications in recent years devoted to the study of the problem of uterine fibroids – relevance, causes and mechanisms of development, provides a class

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14

Matsuda, M., T. Ichimura, M. Kasai, et al. "Preoperative Diagnosis of Usual Leiomyoma, Atypical Leiomyoma, and Leiomyosarcoma." Sarcoma 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/498682.

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Uterine smooth muscle tumors (SMTs) are common pelvic tumors in women, and most of them are diagnosed as usual leiomyoma (UL). Exclusion of malignant disease is important in the management of SMTs. However, differentiation of SMTs remains difficult. In this study, we aimed to improve the preoperative diagnosis of SMTs. We examined 21 ULs, 7 atypical leiomyomas (ALs), and 6 leiomyosarcomas (LMSs), all of which were diagnosed by uterine tumor biopsy. Immunohistochemical findings (low-molecular-mass polypeptide 2 (LMP2) and Ki-67) and clinical features (serum lactate dehydrogenase level and menop

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Senbanjo, OC, TA Ottun, FM Akinlusi, YA Oshodi, KA Rabiu, and AA Adewunmi. "Clinical Presentation of Uterine Leiomyoma and the Outcome of Surgical Management Options in a Nigerian Tertiary Health Facility." Annals of Health Research 9, no. 2 (2023): 136–45. http://dx.doi.org/10.30442/ahr.0902-06-199.

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Background: Effective treatment intervention for uterine leiomyoma is essential to prevent morbidities and associated potential mortalities. Objective: To determine the prevalence, clinical presentation of uterine leiomyoma and the outcome of surgical management options at the Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria. Methods: This was a descriptive retrospective study of cases of uterine leiomyoma from 01 January 2012 to 31 December 2016. The medical records of all patients with the diagnosis of leiomyoma were retrieved. Information was obtained on socio-demogr

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Sotnikova, N. Yu, A. I. Malyshkina, D. N. Voronin, S. N. Nagornyi, and D. L. Voskresnskaya. "Macrophage differentiation in the tissues of myomatous nodes, depending on MRI pattern." Russian Journal of Immunology 24, no. 1 (2021): 69–76. http://dx.doi.org/10.46235/1028-7221-243-mdi.

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Macrophage differentiation is known to be regulated by specific microenvironment invaded by these cells. However, despite numerous studies on pathogenesis of uterine leiomyoma, a common benign tumor of reproductive system, the features of macrophage polarization within myoma nodes are still scarcely studied. The aim of our work was to reveal some differentiation features of macrophages which invade the tissues of myomatous nodes in the patients with different types of uterine leiomyoma (UL) dependent on MRI patterns observed. We have performed a study of 42 patients in their reproductive age w

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Tan, Yang, Jing Han, Zhenglan Wang, Ju Yan, Lin Dong, and Rui Liu. "Different clinical diagnosis end up in the same pathological diagnosis of intravascular leiomyomatosis: Two case reports." Medicine 103, no. 2 (2024): e36887. http://dx.doi.org/10.1097/md.0000000000036887.

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Rationale: Intravascular/intravenous leiomyomatosis (IVL) is a peculiar variant of uterine leiomyoma that is classified as a histologically benign smooth muscle tumor with a biological behavior similar to that of a malignant tumor. It is characterized by the proliferation of leiomyomas spreading along the uterine and extrauterine venous circulation. Patient concerns: Herein, we present 2 cases of IVL who had completely different clinical manifestations to stress the need for constant vigilance of IVL diagnosis and the understanding of uterine leiomyoma heterogenicity. Case 1 was registered for

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Singh, Mrinalini, Krishna Kumar Jha, Prija Poudyal, and Santosh Upadhyay Kafle. "Histopathological spectrum of neoplastic lesions of female reproductive system-a two-year experience in Eastern Nepal." International Journal of Research in Medical Sciences 6, no. 2 (2018): 426. http://dx.doi.org/10.18203/2320-6012.ijrms20180280.

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Background: Neoplastic lesions of female reproductive system (FRS) consist majority of surgical cases. The aim of this study is to find out the frequency distribution of tumors occurring in FRS.Methods: This is a retrospective study carried out in Birat Medical College, situated in eastern Nepal. All formalin fixed surgical specimen of FRS from August 2015 to September 2017 were subjected for histopathology and examined under light microscopy. All neoplastic lesions were included, and non-neoplastic lesions were excluded from the study.Results: A total number of ninety (90) histopathological t

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Conte, Alpha Boubacar, Jihad Jamor, Fatima Zohra Fdili Alaoui, Sofia Jayi, Hikmat Chaara, and Moulay Abdelilah Melhouf. "Uterine smooth muscle tumor of uncertain malignant potential: a case diagnosis, management and follow-up in the department of gynecology-obstetrics II of the Hassan II teaching hospital of Fes in Morocco." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 6 (2020): 2598. http://dx.doi.org/10.18203/2320-1770.ijrcog20202355.

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Rarely diagnosed in authors department, uterine smooth muscle tumor of uncertain malignant potential (STUMP) is one of the histologic types of uterine sarcoma. Among women undergoing hysterectomy or myomectomy for a presumed diagnosis of leiomyoma, 0.01% receive a diagnosis of STUMP. Authors report a case occurring to a patient aged of 55 which was diagnosed, managed successfully and followed-up in authors department.

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Jovanović, Ljubiša, Svetlana Milenković, Luka Andrić, et al. "Uterine Leiomyomas with Specific Histology Features of Two Fumarate Hydratase/Succinate Dehydrogenase-Deficient Tumors: A Double Case Report." Medicina 60, no. 5 (2024): 825. http://dx.doi.org/10.3390/medicina60050825.

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Background and Objectives: Mutations in succinate dehydrogenase (SDH) and fumarate hydratase (FH) give rise to various familial cancer syndromes, with these alterations being characteristic of certain types of histomorphologically specific leiomyomas that hold significant predictive value. Materials and Methods: This study presents two cases of uterine leiomyomas exhibiting rare histomorphological and genetic characteristics, which are crucial for prognosis and further treatment. Results: Distinct histopathological features such as marked nuclear atypia, intracellular eosinophilic globules, an

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Machado-Lopez, Alba, Roberto Alonso, Victor Lago, et al. "Integrative Genomic and Transcriptomic Profiling Reveals a Differential Molecular Signature in Uterine Leiomyoma versus Leiomyosarcoma." International Journal of Molecular Sciences 23, no. 4 (2022): 2190. http://dx.doi.org/10.3390/ijms23042190.

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The absence of standardized molecular profiling to differentiate uterine leiomyosarcomas versus leiomyomas represents a current diagnostic challenge. In this study, we aimed to search for a differential molecular signature for these myometrial tumors based on artificial intelligence. For this purpose, differential exome and transcriptome-wide research was performed on histologically confirmed leiomyomas (n = 52) and leiomyosarcomas (n = 44) to elucidate differences between and within these two entities. We identified a significantly higher tumor mutation burden in leiomyosarcomas vs. leiomyoma

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Al-Shaikh, Abdulrahman F., Abdulla Darwish, Veena Nagaraj, and Abeer Alsada. "A Rare Combination of Ovarian and Uterine Leiomyomas with Goblet Cell Carcinoid of the Appendix." Case Reports in Surgery 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/467243.

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We present a case of the rare combination of unilateral ovarian leiomyoma, uterine leiomyoma, and goblet cell carcinoid tumor of the appendix in a premenopausal woman who presented with right iliac pain. Immunohistochemistry study for desmin (muscle marker) and chromogranin and synaptophysin (neuroendocrine markers) confirmed immunophenotyping origin. Interestingly, both tumors showed positive reaction for estrogen receptor. To our knowledge, such a combination has not been reported previously in the literature. In this paper, the pathogenesis and differential diagnosis of both types of tumors

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Rai, Ujwal, Monasha Vaidya, Gehanath Baral, Smrity Mool Joshi, and Sunita Ray. "Histopathological patterns of benign lesions in hysterectomy specimens." Nepal Journal of Obstetrics and Gynaecology 14, no. 1 (2019): 48–51. http://dx.doi.org/10.3126/njog.v14i1.26628.

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Aims: To audit and evaluate the surgical indications, routes of surgery and types of hysterectomies performed along with histopathological analysis of those hysterectomies in respect to disease of endometrium, myometrium, cervix and fallopian tubes and ovaries for benign conditions. Methods: This is retrospective cross sectional study of all hysterectomy specimens received in the department of Pathology, B and C teaching hospital and research center, Jhapa, Birtamode, Nepal from May 2017 to May 2019. Clinical details were received from the data provided by gynecologists in histopathologi

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Lattuada, Debora, Paola Viganó, Silvia Mangioni та ін. "Accumulation of Retinoid X Receptor-α in Uterine Leiomyomas Is Associated with a Delayed Ligand-Dependent Proteasome-Mediated Degradation and an Alteration of Its Transcriptional Activity". Molecular Endocrinology 21, № 3 (2007): 602–12. http://dx.doi.org/10.1210/me.2006-0206.

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Abstract An alteration of the retinoid pathway can influence the development of uterine leiomyomas in animal models, and retinoids have shown efficacy in inhibiting the growth of this benign tumor both in vitro and in vivo. However, the underlying mechanisms and biological implications are unclear. The present study was based on the demonstration of an accumulation of full-length retinoid X receptor α (RXRα) in leiomyomas that was not associated with a modification of its gene expression. This accumulation was shown to increase the transcription of the RXR-responsive gene cellular retinoic aci

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Mandal, Debasmita, Chaitalli Dattaray, and Sanchita Roy. "Spontaneous Parasitic Leiomyoma: A Rare Clinical Experience." Journal of South Asian Federation of Obstetrics and Gynaecology 5, no. 2 (2013): 85–86. http://dx.doi.org/10.5005/jp-journals-10006-1232.

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ABSTRACT Although leiomyoma is one of the commonest uterine tumors prevalent among reproductive aged women, certain types like parasitic fibroid are rare and among these the primary variety rarer. The present case report is of a primary parasitic fibroid of large size neither connected with uterus and adnexae nor having any history of previous laparoscopic procedures. Aim of our reporting is to acknowledge the rarity, clinical parameters and management. How to cite this article Mandal D, Dattaray C, Roy S. Spontaneous Parasitic Leiomyoma: A Rare Clinical Experience. J South Asian Feder Obst Gy

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Anibor, Ese, Joyce Ekeme Ikubor, Peace Udoh Ubanatu, and Osagiemike Odigie. "Uterine Myoma: an Ultrasonographic Study of Patterns at the Central Hospital in Warri, Delta State, Nigeria." Pakistan Journal of Medical and Health Sciences 15, no. 9 (2021): 2975–78. http://dx.doi.org/10.53350/pjmhs211592975.

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This analysis considered the sonographic patterns of uterine myoma seen at the Central Hospital in Warri, Delta State, Nigeria. Ultrasonographic records of the uteri of 312 women seen from December 2017 to January 2021 were retrieved from the Central Hospital in Warri, Nigeria. Information on the leiomyoma size, weight, occurrence site, types and number of nodules were fetched from available ultrasonographic reports. Ethical approval was obtained from the Research/ Ethical Committee of Human Anatomy Department at the Delta State University, Abraka, and the Warri Central Hospital. Data was ente

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Sasaki, Hiroko, Noriyuki Ohara, Qin Xu, et al. "A Novel Selective Progesterone Receptor Modulator Asoprisnil Activates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Signaling Pathway in Cultured Human Uterine Leiomyoma Cells in the Absence of Comparable Effects on Myometrial Cells." Journal of Clinical Endocrinology & Metabolism 92, no. 2 (2006): 616–23. http://dx.doi.org/10.1210/jc.2006-0898.

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Abstract Context: We previously demonstrated that asoprisnil, a selective progesterone receptor modulator, induces apoptosis of cultured uterine leiomyoma cells. This study was conducted to evaluate whether asoprisnil activates TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptotic pathway in cultured uterine leiomyoma and matching myometrial cells. Objective and Methods: After subculture in phenol red-free DMEM supplemented with 10% fetal bovine serum for 120 h, cultured cells were stepped down to serum-free conditions for 24 h in the absence or presence of graded concentrations of

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Shved, Natalia, Anna Egorova, Natalia Osinovskaya, and Anton Kiselev. "Development of Primary Monolayer Cell Model and Organotypic Model of Uterine Leiomyoma." Methods and Protocols 5, no. 1 (2022): 16. http://dx.doi.org/10.3390/mps5010016.

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Cellular technologies are one of the most promising areas of biomedicine, which is based on the isolation of cells of various types, followed by their cultivation and use, or the use of their metabolic products, for medical purposes. Today, a significant part of biomedical research is carried out in vitro. On the other hand, organotypic culture can be used as a powerful model system and can complement cell culture and in vivo studies in different biomedical applications. Uterine leiomyoma (UL) is a very common benign tumor and often leads to many reproductive complications. Herein we describe

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Hayashi, Takuma, Kenji Sano, Nobuo Yaegashi, Kaoru Abiko, and Ikuo Konishi. "Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor." Current Issues in Molecular Biology 45, no. 8 (2023): 6190–201. http://dx.doi.org/10.3390/cimb45080390.

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The benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, and treatment methods. Uterine leiomyosarcoma develops fr

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Timofeeva, Nataliya B., Aleksandr A. Bezmenko, Elena V. Osadchaya, and Victor G. Borshchevsky. "Clinical case of treatment of giant uterine fibroid." Russian Military Medical Academy Reports 43, no. 1 (2024): 87–90. http://dx.doi.org/10.17816/rmmar619029.

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Uterine leiomyomas are the most common type of benign tumor that occurs in the female pelvis. Uterine leiomyoma is a tumor of smooth muscles. Its prevalence is higher in the reproductive age group and decreases after menopause. Giant uterine fibroids are a rare tumor of the uterus. Giant uterine fibroids, especially subcutaneous types, are complicated by malnutrition due to deterioration of their blood supply. The complaints of the patients are non-specific: an increase in the size of the abdomen, aching pains, sometimes difficulty urinating and defecating. A physical examination reveals a gia

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B.N, Gayathri, Mallikarjun A. Pattanashetti, and Priyadarshini M.M. "Histopathological Study of Myometrial Lesions of Uterus in a Tertiary Care Hospital of South India." Journal of Evidence Based Medicine and Healthcare 8, no. 06 (2021): 293–97. http://dx.doi.org/10.18410/jebmh/2021/57.

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BACKGROUND The most commonly done gynaecological surgery worldwide is hysterectomy. Myometrial lesions contribute to majority of cases with abnormal uterine bleeding. Leiomyoma and adenomyosis are most common lesions seen in the myometrium. The present study was undertaken to identify the various types of myometrial pathologies in hysterectomy samples. METHODS This is a two-year retrospective cross-sectional study done from January 2017 to December 2018, in the Department of Pathology, Kodagu Institute of Medical Sciences, Madikeri. All the patients who underwent hysterectomy and myomectomy fo

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Titova, G. P., M. M. Damirov, L. S. Kokov, O. N. Oleynikova, and G. E. Belozerov. "Structural changes in uterine tissues after uterine artery embolization in patients with leiomyoma complicated by uterine bleeding." Gynecology 20, no. 1 (2018): 78–82. http://dx.doi.org/10.26442/2079-5696_20.1.78-82.

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Uterine leiomyoma (UL) is often complicated by the development of uterine bleeding. In urgent gynecology for the implementation of endovascular hemostasis, uterine artery embolization (UAE) is used. Performing UAE allows to stop and/or significantly reduce the intensity of bleeding and prepare a patient for surgical intervention. At the same time, the morphological changes that occur in uterine tissues in operated UL patients after performing the UAE are not studied. The aim was to study the peculiarities of pathomorphological changes in uterine tumors and tissues in operated UL patients compl

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Gao, Xiaohua, Linda Yu, Lysandra Castro, et al. "An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells." American Journal of Physiology-Endocrinology and Metabolism 303, no. 8 (2012): E1025—E1035. http://dx.doi.org/10.1152/ajpendo.00107.2012.

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Previously, we reported that fenvalerate (Fen) promotes proliferation of human uterine leiomyoma (UtLM) cells by enhancing progression of cells from G0-G1to S phase through molecular mechanisms independent of estrogen receptor-α and -β. The cyclin-dependent kinase (CDK) inhibitor p27, which blocks G1to S phase transitions and is an important regulator of CDK2, is often decreased in hormonally regulated diseases, including uterine leiomyomas. Therefore, we were interested in whether Fen could regulate the expression of p27 and whether p27 might play a role in Fen-induced cell proliferation. Exp

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Kornatska, A., A. Dubchak, M. Flaksemberg, and I. Baranetska. "The application of ultrasonography to select tactics for treatment of women of reproductive age with uterine leiomyoma." Bukovinian Medical Herald 24, no. 4 (96) (2020): 32–40. http://dx.doi.org/10.24061/2413-0737.xxiv.4.96.2020.100.

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Objective. To study the condition of the pelvic organs in women of reproductive age with uterine leiomyoma UL, depending on the type of treatment based on ultrasonographic monitoring.Materials and methods. 299 women of reproductive age were examined. Patients were divided into 3 groups: 1 group consisted of 159 women with uterine leiomyoma (UL) who underwent surgical treatment, 2 group – 120 women with UL who underwent conservative treatment, 3 control group consisted of 20 healthy women of reproductive age. In order to obtain the most complete information about the size of the uterus, the str

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В., С. Ольшевський, and В. Ольшевська О. "OPERATIVE DELIVERY IN WOMEN WITH BENIGN UTERINE TUMORS." REPRODUCTIVE ENDOCRINOLOGY, no. 48 (August 29, 2019): 68–76. https://doi.org/10.18370/2309-4117.2019.48.68-76.

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Objective of the study: to determine the role of operative delivery in the childbirth tactics for women with benign uterine tumors based on the identification of pathogenetically substantiated criteria for operative birth, to prevent obstetric and perinatal complications. Materials and methods. In 110 women with uterine leiomyoma (LM) – 77 (70.0%) with one node (Group 1) and 33 (30.0%) with multiple nodes (Group 2) delivery tactics were defined. For this purpose, the type of LM, the location of the nodes relative to the placenta, complications of pregnancy, childbirth were revealed and a

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Zhang, Qing, Julianne Ubago, Li Li, et al. "Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma." Cancer 120, no. 20 (2014): 3165–77. http://dx.doi.org/10.1002/cncr.28900.

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Serra, David, Pedro Amaro, Margarida Gonçalo, et al. "Gastric Leiomyoma and Hyperplastic Polyposis Coli in a Patient with Multiple Cutaneous and Uterine Leiomyomatosis." Journal of Cutaneous Medicine and Surgery 16, no. 3 (2012): 208–11. http://dx.doi.org/10.1177/120347541201600315.

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Background: Cutaneous leiomyomatosis has been associated with multiple uterine myomas and, more recently, with germline heterozygous mutations of the FH gene and certain types of renal cancer. Despite the growing amount of knowledge concerning this genodermatosis, its clinical spectrum remains incompletely characterized. Objective: We report the observation of a patient with multiple cutaneous and uterine leiomyomatosis (MCUL) with unusual gastrointestinal manifestations. Methods and Results: A gastric leiomyoma was diagnosed on a 38-year-old female MCUL patient on endoscopy performed because

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Kothai Ramalingam, Atheena Gigi, Anu Sara Thomas, Abdul Mohsin Mootaparambil, and Arul Balasubramanian. "Drug utilisation pattern and risk factor assessment on abnormal uterine bleeding in reproductive aged women in a tertiary care hospital." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 2687–90. http://dx.doi.org/10.26452/ijrps.v10i4.1529.

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To study the drug utilization pattern and risk factor assessment on abnormal uterine bleeding in reproductive-aged women in a tertiary care hospital at Salem district, Tamil Nadu, India. This retrospective study was carried out for a period of 6 months from November 2017 to April 2018 in which 150 prescriptions were selected for study by considering the inclusion and exclusion criteria. A total of 150 prescriptions were analyzed in reproductive-aged women. Patients of age group between 41-50 years were mostly diagnosed 75 (50%) of abnormal uterine bleeding. Considering the types of AUB, most o

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Tamura, Ryo, Katsunori Kashima, Mina Asatani, et al. "Preoperative Ultrasound-Guided Needle Biopsy of 63 Uterine Tumors Having High Signal Intensity Upon T2-Weighted Magnetic Resonance Imaging." International Journal of Gynecologic Cancer 24, no. 6 (2014): 1042–47. http://dx.doi.org/10.1097/igc.0000000000000189.

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ObjectiveThe differential diagnosis between uterine sarcoma and benign leiomyoma is difficult when made only by magnetic resonance imaging (MRI); it usually requires an additional preoperative diagnostic procedure. We report our results using ultrasound-guided needle biopsy for these types of uterine tumors.MethodsUltrasound-guided needle biopsy was performed on 63 patients with uterine smooth muscle tumors suspected of malignancy by MRI. We compared the results of presurgical biopsy against the postsurgical pathology of the tumor.ResultsAmong 63 patients with a high signal intensity of the ut

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Campione, Elena, Monia Di Prete, Gaetana Costanza, et al. "Increased Occurrence of Cutaneous Leiomyomas and Dermatofibromas in Patients with Uterine Leiomyomas without Fumarate Hydratase Gene Mutations." Dermatopathology 10, no. 3 (2023): 231–43. http://dx.doi.org/10.3390/dermatopathology10030032.

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Leiomyomas are smooth muscle-derived benign neoplasms that can affect all organs, most frequently in the uterus. Fumarate hydratase gene (FH) mutation is characterised by an autosomal dominant disease with increased occurrence of renal tumours, but also by cutaneous (CLs) and uterine leiomyomas (ULs). So far, an increased occurrence of skin tumours in non-mutated patients with ULs has not been verified. To this aim, a case-group of women who were FH non-mutated patients surgically treated for ULs (n = 34) was compared with a control-group (n = 37) of consecutive age-matched healthy women. The

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Miao, Yali, Jirui Wen, Liwei Huang, Jiang Wu, and Zhiwei Zhao. "Diagnosis and Management of Ovarian Tumor in Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome." BioMed Research International 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/2369430.

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In the most recent publications on Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, the uterine remnants and ovaries in patients may develop uterine remnant leiomyoma, adenomyosis, or ovarian tumor, and this can lead to problems in differential diagnosis. Here we summarize the diagnosis methods and available interventions for ovarian tumor in MRKH syndrome, with emphasis on the relevant clinical findings and illustrative relevant case. According to the clinical findings and illustrative relevant case, with the help of imaging techniques, ovarian tumors can be detected in the pelvis in patients

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Podgornaya, A. S., A. Yu Zaharko, O. V. Murashko, and K. V. Bronskaya. "Myomectomy: surgical tactics, reproductive outcomes." Medical and Biological Problems of Life Activity, no. 1 (May 22, 2023): 82–88. http://dx.doi.org/10.58708/2074-2088.2023-1(29)-82-88.

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The article highlights modern approaches to the surgical treatment of uterine fibroids in patients of reproductive age, depending on the size and type of localization of the node in the uterus in accordance with the FIGO classification. It has been established that submucosal uterine fibroids of types 0, 1, 2 are subject to hysteroscopic removal, since their effect on the onset, prolongation of pregnancy and reproductive outcomes has been proven. Intramural uterine leiomyomas are subject to removal if the node size is more than 5 cm or other unidentified causes of infertility in patients with

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WANG, Subo, Zhenhua ZHAO, Yu ZHANG, et al. "Quantitative perfusion histogram parameters of dynamic contrast-enhanced MRI to identify different pathological types of uterine leiomyoma." Journal of Zhejiang University (Medical Sciences) 50, no. 1 (2021): 97–105. http://dx.doi.org/10.3724/zdxbyxb-2021-0036.

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Shivani, Chauhan, and Megha Bahuguna Dr. "MANAGEMENT OF UTERINE FIBROID THROUGH AYURVEDA – A CASE STUDY." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 892–98. https://doi.org/10.5281/zenodo.15302631.

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Uterine fibroid (leiomyomas, fibromyomas or simply myomas) are generally benign uterine neoplasms, commonly encountered in gynaecological practice (5-20% of women in the reproductive age group). They are slow growing tumours and take 3-5 years to be clinically palpable, unlike ovarian tumours. The fibroids are located in uterine and extra uterine are - A) Uterine = i) intramural / interstitial- grow within interstitial wall 75% ii) Sub mucous - grow towards peritoneal surface 5% iii) Sub serous - grow towards the uterine cavity 15% B) Extra uterine- most common in cervical fibroid.Le

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Задорожна, Т. Д., Н. О. Редько, Т. Ф. Татарчук, Н. В. Косей, and С. М. Килихевич. "Hysteroscopic, morphofunctional and immunohistochemical endometriun features in women with uterine leiomyoma after different types of organ-preserving treatment." Reproductive Endocrinology, no. 26 (December 28, 2015): 42. http://dx.doi.org/10.18370/2309-4117.2015.26.42-48.

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Biswas, Sima, Rajorshi Keshri, and Bivas Bala. "Prevalence and outcome of hysterectomy in a peripheral medical college – A data-based retrospective study." Asian Journal of Medical Sciences 13, no. 4 (2022): 118–22. http://dx.doi.org/10.3126/ajms.v13i4.41323.

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Aims and Objectives: The study aimed evaluation of prevalence, demographic features, clinical presentation, indication, intra-operative findings, different types of operation, and histopathological diagnosis of patients who underwent hysterectomy in our center. Materials and Methods: This retrospective study done over 3 years from May 2017 to April 2020 in Department of Obstetrics and Gynecology of Rampurhat Government Medical College, West Bengal India. Case record and data of each patient were obtained from medical record section of the hospital and analyzed after taking permission of concer

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Al-Sabbagh, Wafaa Redha Mohammed, Zainab Abbas Hassooni, and Zainab Al Ali. "Immunohistochemical and histopathological analysis of hysterectomy cases." International Journal of Innovative Research and Scientific Studies 8, no. 3 (2025): 4150–56. https://doi.org/10.53894/ijirss.v8i3.7451.

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To study the immunohistochemical role of PTEN in the diagnosis of endometrial hyperplasia, one of the challenging diagnoses in uterine diseases, we highlight the most important histopathological diagnoses underlying different types of uterine surgeries. Both benign and malignant diseases are now treated by hysterectomy, with an increasing number of such surgeries. The type of surgery depends on the medical staff's experience, facilities, provisional diagnosis, and the patient’s desire. Differentiation between typical and atypical endometrial hyperplasia is one of the challenging diagnoses in g

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Katke, Rajshree Dayanand, Pushpa C, and Sonia Asrani. "Giant uterine leiomyoma (5 kg) with bunch of 45 fibroids: a challenging case during covid-19 pandemic." Obstetrics & Gynecology International Journal 12, no. 4 (2021): 199–201. http://dx.doi.org/10.15406/ogij.2021.12.00576.

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Leiomyomas are the most common benign tumours of the uterus, arising from the smooth muscles of the uterus but containing varying amount of fibrous tissue. These grow under the influence of oestrogen and progesterone. Fibroids undergo various types of degenerations, most common being hyaline degeneration. Most of them are asymptomatic. Large fibroids may cause pain, pressure symptoms or menstrual dysfunctions. Large fibroids are rare and require expertise to operate them to avoid blood loss, prevent inadvertent injury to ureters, bladder, bowel and the surrounding vital structures. Here we pre

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Sakko, Yesbolat, Gulzhanat Aimagambetova, Milan Terzic, et al. "The Prevalence, Indications, Outcomes of the Most Common Major Gynecological Surgeries in Kazakhstan and Recommendations for Potential Improvements into Public Health and Clinical Practice: Analysis of the National Electronic Healthcare System (2014–2019)." International Journal of Environmental Research and Public Health 19, no. 22 (2022): 14679. http://dx.doi.org/10.3390/ijerph192214679.

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Objectives: Major gynecological surgeries are indicated for the treatment of female genital pathologies. It is key to examine trends in gynecologic surgical procedures and updated recommendations by international gynecological societies to find opportunities for improvement of local guidelines. To date, a very limited number of reports have been published on the epidemiology of gynecological surgeries in Kazakhstan. Moreover, some local guidelines for gynecological conditions do not comply with the international recommendations. Thus, this study aims to investigate the prevalence, indications,

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Kim, K. P., J. S. Lee, C. Ahn, Y. K. Choi, and E. B. Jeung. "156 EFFECT OF 2-METHOXYESTRADIOL (2-ME) ON HUMAN UTERINE LEIOMYOSARCOMA." Reproduction, Fertility and Development 28, no. 2 (2016): 208. http://dx.doi.org/10.1071/rdv28n2ab156.

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2-Methoxyestradiol (2-ME) is an endogenous metabolite of 17β-oestradiol (E2) and has affinity for oestrogen receptors. It was reported as a promising antitumour drug due to antiproliferative activity in many tumour cell types. It has also been used in several preclinical and clinical studies for treatment of solid tumours. Thus, several studies have been conducted to investigate the cytotoxic effect of 2-ME on tumour cell lines in which it induced G2/M cell cycle arrest and subsequent apoptosis. Uterine leiomyosarcoma is a rare form of malignant smooth muscle cell tumour in the uterus muscle l

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