Academic literature on the topic 'Typhoid organism'
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Journal articles on the topic "Typhoid organism"
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Koirala, Kanika Deshpande, Duy Pham Thanh, Sudeep Dhoj Thapa, Amit Arjyal, Abhilasha Karkey, Sabina Dongol, Upendra Man Shrestha, Jeremy J. Farrar, Buddha Basnyat, and Stephen Baker. "Highly Resistant Salmonella enterica Serovar Typhi with a NovelgyrAMutation Raises Questions about the Long-Term Efficacy of Older Fluoroquinolones for Treating Typhoid Fever." Antimicrobial Agents and Chemotherapy 56, no. 5 (February 27, 2012): 2761–62. http://dx.doi.org/10.1128/aac.06414-11.
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ABSTRACTAs a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exceptional. Here we report ofloxacin treatment failure in typhoidal patient infected with a novel, highly fluoroquinolone-resistant isolate ofSalmonella entericaserovar Typhi. The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment.
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Vigliani, Marguerite B., and Anna I. Bakardjiev. "First Trimester Typhoid Fever with Vertical Transmission ofSalmonellaTyphi, an Intracellular Organism." Case Reports in Medicine 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/973297.
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We report a case in which placental abruption occurred at 16 weeks following first trimester diagnosis and treatment for typhoid fever. UnexpectedlySalmonella entericaserovar Typhi (S.Typhi) was found in fetal tissues at autopsy. Using information from the murine model of typhoid fever in pregnancy, we draw parallels betweenS.Typhi andL. monocytogenesto develop a plausible hypothesis to explain how this organism was able to cross the placenta in the first trimester to cause abruption, inflammation, and expulsion of the fetus and placenta. We hope that this model for understanding placental infections by the hematogenous route helps to raise awareness that organisms not typically associated with TORCH infection can nevertheless cause placental infection and pregnancy loss.
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Boichenko, M. N., V. V. Zverev, and E. V. Volchkova. "INTERACTION OF SALMONELLA WITH HOST ORGANISM." Journal of microbiology epidemiology immunobiology, no. 4 (August 28, 2017): 91–100. http://dx.doi.org/10.36233/0372-9311-2017-4-91-100.
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Diseases caused by Salmonella enterica species bacteria remain a healthcare challenge. Salmonella enterica species is divided into typhoid serovars that cause systemic infection and non-typhoid serovars that most frequently have a course of gastroenteritis with a development of inflammatory diarrhea. Both types of salmonella are opportunistic intracellular parasites able to invade and reproduce in both professional and non-professional phagocytes, e.g. M- cells and enterocytes. Invasion of cells and reproduction in them relates to functioning of salmonella pathogenicity island genes that determined synthesis of the third type of secretory system (T3SS). Contrary to the salmonella typhoid group serovars, non-typhoid serovars cause a development of inflammatory diarrhea, and effector molecules of T3SS as well as innate immunity components take part in it.
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Kanwal, Muqadas, Fadia Waheed, Hafsa Shahzadi, Muhammad Shahbaz, and Ahsan Noor. "A Review on Recent Developments for the Cure of Salmonella Enterica Serovar Typhi, the Causative Agent for Typhoid Fever." JOURNAL OF MICROBIOLOGY AND MOLECULAR GENETICS 1, no. 2 (August 26, 2020): 1–8. http://dx.doi.org/10.52700/jmmg.v1i2.13.
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Salmonella enterica typhi is typhoid or enteric fever agent which is a serious water-borne disease and is a human host restricted organism. So, an important cause of death in underdeveloped countries, typhoid fever is a public health concern. Worldwide, 15-30 million people suffer from this disease every year, causing more than 200,000 deaths. However, several lines of evidence suggest that the advent of multidrug-resistant non-typhoidal strains of Salmonella has an important impact on the effectiveness of current strategies, including reductions in the effectiveness of early empirical treatment for controlling and managing foodborne diseases. Recent studies show more than 2000 strains of salmonella bacteria with around 100 strains connected to human infection - with myriad common strains from Salmonella Heidelberg to Typhimurium to Salmonella infantis. The multi-medicinal strain S. Typhi H58 has developed into the main circulating strain in many parts of the world, and an extensively drug-resistant (XDR) subclade has been recently found. Most of the people agree that the most effective way to control infection is to vaccinate susceptible populations. The commercially available live attenuated (Ty21a) vaccine, on the other hand, is not recommendable for children under the age of six, whereas the poor long-term efficacy of Vi-polysaccharide-based vaccine against typhoid fever. Furthermore, there are no vaccines available to protect against S. para typhi infection. Subsequently, a new formulation is urgently needed that can provide long-term protection against both pathogens while healthy for all age groups. Pakistan is the first country in the world to incorporate the WHO-recommended conjugate vaccine into its routine typhoid immunization program (2019). As a result, the purpose of this review is to describe the various diagnostic procedures for typhoid fever diagnosis and cure development. This article addressed some of the elements and components required for the implementation of typhoid vaccine.
With an analysis of past and current enteric fever vaccines in progress as well as the ethical issues relevant to CHIM in typhoid vaccine efficacy research, we have combined the new methods to predict typhoid burden and vaccines impact.
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Goel, Apoorv, and Roli Bansal. "Massive Lower Gastrointestinal Bleed caused by Typhoid Ulcer: Conservative Management." Euroasian Journal of Hepato-Gastroenterology 7, no. 2 (2017): 176–77. http://dx.doi.org/10.5005/jp-journals-10018-1242.
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ABSTRACT Typhoid fever is caused by gram-negative organism Salmonella typhi. The usual presentation is high-grade fever, but complications like gastrointestinal (GI) hemorrhage and perforation are also seen frequently. With the advent of antibiotics, these complications are rarely seen now. We present a case of a young female who was admitted with a diagnosis of typhoid fever presented with a massive GI bleed from ulcers in the terminal ileum and was managed conservatively without endotherapy and surgery. How to cite this article Goel A, Bansal R. Massive Lower Gastrointestinal Bleed caused by Typhoid Ulcer: Conservative Management. Euroasian J Hepato-Gastroenterol 2017;7(2):176-177.
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Dimitrov, Tzonyo, Edet E. Udo, Osama Albaksami, Abdul A. Kilani, and El-Din M. R. Shehab. "Ciprofloxacin treatment failure in a case of typhoid fever caused by Salmonella enterica serotype Paratyphi A with reduced susceptibility to ciprofloxacin." Journal of Medical Microbiology 56, no. 2 (February 1, 2007): 277–79. http://dx.doi.org/10.1099/jmm.0.46773-0.
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This report describes a case of ciprofloxacin treatment failure in a patient with enteric fever caused by Salmonella enterica serotype Paratyphi A. The organism was isolated from a blood culture from a patient who was treated with oral ciprofloxacin (500 mg every 12 h) for 13 days. The organism showed reduced susceptibility to ciprofloxacin (MIC 0.75 μg ml−1) and was resistant to nalidixic acid. The patient was then placed on intravenous ceftriaxone (1 g every 12 h) and responded within 3 days. The patient was discharged after 9 days on ceftriaxone with no relapse on follow-up. This case adds to the increasing incidence of treatment failures with ciprofloxacin in typhoid fever caused by typhoid salmonellae with reduced susceptibility to ciprofloxacin. It also highlights the inadequacy of current laboratory methods for fluoroquinolone susceptibility testing in adequately predicting in vivo activity of ciprofloxacin against typhoid salmonellae and supports calls for new guidelines for fluoroquinolone susceptibility testing of these organisms.
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Gajurel, Damodar, Rabi Prakash Sharma, Krishna Dhungana, Niranjan Acharya, Prasant Karki, and Sudikshya Acharya. "Age Distribution of Patients Presenting With Typhoid and Paratyphoid Fever in Kathmandu, Nepal." Journal of Nobel Medical College 6, no. 2 (April 5, 2018): 25–28. http://dx.doi.org/10.3126/jonmc.v6i2.19566.
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Background: Enteric fever is a significant cause of morbidity in Nepal. In the past, Salmonella entericaserovar Typhi (S. Typhi) was the major causative organism of enteric fever. However, more recently, Salmonella entericaserovar Paratyphi (S.Paratyphi) A has been isolated from most patients presenting with enteric fever in various regions of Nepal. This study aimed to evaluate age differences in patients presenting with typhoid and paratyphoid fever.Materials & Methods: Between December 2014 and October 2015, 186 patients presented with enteric fever to the Civil Service Hospital in Kathmandu. S. Typhi and S.Paratyphi A were isolated from blood cultures in 48.4% and 51.6% of the cases, respectively. Age groups of the patients infected with either serovar were compared.Results: The mean age of patients from whom S. Typhi was isolated was 19.3 years, while the mean age of patients from whom S. Paratyphi A was isolated was 25.2 years; p=0.025.Conclusion: Our study shows that age is an important factor in having either typhoid or paratyphoid fever. This will help in the prevention of typhoid and paratyphoid fever in various age groups.Journal of Nobel Medical CollegeVolume 6, Number 2, Issue 11 (July-December, 2017) Page:25-28
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Zaki, Syed Ahmed, and Sunil Karande. "Multidrug-resistant typhoid fever: a review." Journal of Infection in Developing Countries 5, no. 05 (January 19, 2011): 324–37. http://dx.doi.org/10.3855/jidc.1405.
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Introduction: Multidrug-resistant typhoid fever (MDRTF) is defined as typhoid fever caused by Salmonella enterica serovar Typhi strains (S. Typhi), which are resistant to the first-line recommended drugs for treatment such as chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole. Since the mid-1980s, MDRTF has caused outbreaks in several countries in the developing world, resulting in increased morbidity and mortality, especially in affected children below five years of age and those who are malnourished. Methodology: Two methods were used to gather the information presented in this article. First PubMed was searched for English language references to published relevant articles. Secondly, chapters on typhoid fever in standard textbooks of paediatric infectious diseases and preventive and social medicine were reviewed. Results: Although there are no pathognomonic clinical features of MDRTF at the onset of the illness, high fever ( > 104°F), toxaemia, abdominal distension, abdominal tenderness, hepatomegaly and splenomegaly are often reported. The gold standard for the diagnosis of MDRTF is bacterial isolation of the organism in blood cultures. Ciprofloxacin and ceftriaxone are the drugs most commonly used for treatment of MDRTF and produce good clinical results. Conclusion: MDRTF remains a major public health problem, particularly in developing countries. Mass immunization in endemic areas with either the oral live attenuated Typhi 21a or the injectable unconjugated Vi typhoid vaccine, rational use of antibiotics, improvement in public sanitation facilities, availability of clean drinking water, promotion of safe food handling practices and public health education are vital in the prevention of MDRTF.
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Ali, Nouman Mansoor, Rabail Nasr, Mehroze Rehman, and Syed Uzair Mahmood. "Typhoid burden, drug resistance and Pakistan’s stance against it." International Journal Of Community Medicine And Public Health 8, no. 8 (July 27, 2021): 4082. http://dx.doi.org/10.18203/2394-6040.ijcmph20213046.
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Salmonella typhi is a gram negative, rod shaped bacteria that features a polysaccharide capsule, flagella for motility and fimbria for adhesion to the epithelial cells of intestinal mucosa. The organism is responsible for causing enteric fever and in severe cases it leads to complications such as intestinal perforation which can lead to death. The mainstay of treatment of typhoid fever is antibiotic therapy but unfortunately the emergence of MDR (multidrug resistant) and XDR (extensively drug resistant) strains pose a major threat to the successful treatment of typhoid. Around 200,000 global deaths can be associated with typhoid and most cases are seen in low socioeconomic countries with inadequate healthcare infrastructure particularly those that are densely populated, among them Pakistan is considered as high-risk country according to WHO criteria. Prevention strategies include education of the masses regarding hand hygiene, cleanliness and consumption of clean food and water. In 2019 Pakistan encountered an epidemic of XDR typhoid and to control it, Government introduced typhoid vaccine in its nationwide vaccination program, and is hopeful that it will decrease the burden of disease on state and its citizens.
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VIGLIANI, MARGUERITE B., and ANNA I. BAKARDJIEV. "INTRACELLULAR ORGANISMS AS PLACENTAL INVADERS." Fetal and Maternal Medicine Review 25, no. 3-4 (November 2014): 332–38. http://dx.doi.org/10.1017/s0965539515000066.
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In an era of evidence-based medicine, physicians sometimes forget the value of anecdotes in stimulating thought about clinical problems. Our recent report on typhoid fever in a pregnant woman at 12 weeks of gestation is a good example. In spite of culture-proven diagnosis and appropriate treatment of the mother with antibiotics, fetal loss occurred at 16 weeks of gestation. Salmonella typhi was found in the fetal lung on autopsy, consistent with vertical transmission of the organism. None of the clinicians caring for the patient had imagined that gram-negative bacteria could cross the placenta and kill the fetus in spite of early diagnosis and treatment with appropriate antibiotics.
Books on the topic "Typhoid organism"
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Ramachandran, Raja, and Vivekanand Jha. Renal involvement in other infections. Edited by Vivekanand Jha. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0198_update_001.
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Renal involvement has been described in patients with many other infections and this chapter discusses several of these.Water-borne infections are a common cause of acute kidney injury (AKI) worldwide but especially in tropical regions. Cholera is notoriously dangerous but any other cause of fluid-depletion may achieve the same. Typhoid fever is more likely to cause AKI from its complications than directly, but a small proportion of patients have glomerulonephritis.Meliodosis is caused by the intracellular organism Burkholderia pseudomallei. It typically affects workers in paddy (rice) fields in the rainy season, and may cause a local, genitourinary infection or an acute melioidosis septicaemia with a high incidence of AKI and mortality. Those with other chronic conditions are at greatest risk.Obstetric infections as a result of unsafe deliberate abortion or post-partum are a very common (often the most common) cause of AKI in developing countries, and a major cause of avoidable death in young women.
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Matthews, Philippa C. Infections caused by Gram-negative bacteria. Edited by Philippa C. Matthews. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198737773.003.0004.
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This chapter consists of short notes, diagrams, and tables to summarize Gram-negative organisms that are significant causes of disease in the tropics and subtropics. This includes Escherichia coli, Shigella, and Salmonella species (including typhoid and paratyphoid), Brucella, melioid, Campylobacter, and meningococci. For ease of reference, each topic is broken down into sections, including classification, epidemiology, microbiology, pathophysiology, clinical syndromes, diagnosis, treatment, and prevention.
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Sun, Lisa, and Michael V. Johnston. Rickettsial Diseases. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0157.
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Tick-borne rickettsioses are emerging as more important health problems throughout the world. The spotted fever group including Rickettsia rickettsia can cause encephalopathy, meningitis and brain damage by selectively targeting capillary endothelial cells in the brain, and stimulating inflammation, capillary leakage, hemorrhage, and intravascular coagulation. Rickettsia are are arthropod-borne gram-negative coccobacilli bacteria and are obligate intracellular organisms that do not survive in artificial medium. In North and South America, the most common rickettsial disorder is rocky mountain spotted fever (RMSF) transmitted by the dog tick Dermacentor variabilis or the wood tick Dermacentor andersoni. A characteristic “starry sky” pattern can be seen on MRI imaging of the brain in some patients with RMSF encephalopathy and is thought to reflect the organisms targeting of brain endothelial cells in capillaries the white matter. Early treatment with doxycycline is curative and reverses signs of encephalopathy if given within a few day of onset, but delayed treatment can be associated with permanent neurological disability. The typhus group of rickettsia bacteria include R. prowazekii, which causes epidemic typhus and R. typhi, which causes murine typhus (endemic) typhus in tropical and subtropical parts of the world. Flying squirrels and humans carry R prowazekii and rats are carry R. typhi. Q fever caused by the rickettsia organism Coxiella burnetti is transmitted from farm animals including sheep and is seen throughout the world including the United States.
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Pearson, Andrew. Tularaemia. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0031.
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Tularaemia is a plague-like bacterial disease of animals (particularly rodents, hares, and rabbits) and man caused by five subspecies of Francisella. Two subspecies predominate: F. tularensis tularensis in North America and F. tularensis holarctica throughout the northern hemisphere. F. tularensis occurs in persistent natural foci causing localized epidemics and sporadic cases in man.Francisella tularensis subspecies tularensis was described originally as causing a more virulent form of tularaemia than was seen in Europe. More recently recognized are subpopulations of Francisella tularensis subspecies tularensis which have markedly different virulence for man. These have been designated A1a, A1b and A2. Infections resulting from type A1b have been shown to have an attributable mortality of 24% as compared to 4% for tularaemia caused by A1a types.F. tularensis is one of the most potent bacterial pathogens affecting humans with an infective dose from 1 to 10 organisms. The incubation period is usually 3–5 days (range from 1–21 days). Onset of disease is abrupt, with fever, chills, fatigue, general body aches, and headache. When the bacteria are acquired through skin or mucous membranes, tender regional node enlargement may become conspicuous. When bacteria are inhaled, the infection will result in deep lymph node enlargement.The clinical epidemiology of human infection is complex since it relates to one of four modes of transmission of the agent harboured in multiple hosts from diverse ecosystems. Clinical presentation of the human disease is indicative of both the mode of transmission and often the source of infection in a specific ecosystem. Tularaemia presenting as ulceroglandular disease results from either vector-borne infection from mosquito or tick bites or occurs as a result of animal contact from bites, hunting or from skinning hares or muskrats. Oropharyhgeal and typhoidal infections predominate in waterborne outbreaks of F. tularensis holarctica. Pulmonary or influenza disease results from airborne transmission associated with either farmers moving rodent contaminated hay or laboratory acquired infection. An intentional aerosol release of F. tularensis tularensis would be expected to result in clinical manifestations similar to those recognized in natural respiratory tularaemia. Both vector-borne and airborne transmission of F. tularensis may both be associated with florid skin manifestations as a presenting symptom of tularaemia. Pulmonary or typhoidal forms of the tularaemia may occur as a complication of localized infection.
Book chapters on the topic "Typhoid organism"
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William Tong, C. Y. "Different Types of Vaccines." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0061.
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Vaccines can be classified according to their nature into the following types: ● Inactivated vaccines: ■ Whole organism; ■ Acellular extracts. ● Live attenuated vaccines. ● Toxoid vaccines. ● Subunit vaccines. ● Conjugate vaccines. ● DNA vaccines. ● Recombinant vector vaccines. Inactivation of the whole organism is the most basic form of vaccine produced by killing the micro-organism causing the disease using heat, chemical or radiation and presents all the antigens in the inactivated organism as a vaccine to induce immunity in the recipient. Other methods to produce an inactivated vaccine is by extracting acellular components of the organism through filtration. Examples of inactivated bacterial vaccines currently in use include: ● Anthrax—sterile filtrate from cultures of the Sterne strain of B. anthracis. ● Cholera—oral inactivated vaccine with 1mg of recombinant cholera toxin B (rCTB) in a liquid suspension of four strains of killed V. cholerae O1, representing subtypes Inaba and Ogawa and biotypes El Tor and classical. ● Pertussis—acellular vaccine has replaced previously used whole cell vaccine. ● Typhoid—purified Vi capsular polysaccharide from S. typhi; NB: the injectable, killed, whole-cell typhoid vaccine which contains heat-inactivated, phenol-preserved S. typhi organisms is no longer in use in the UK. Examples of inactivated viral vaccines currently in use in the UK include: ● Hepatitis A virus. ● Hepatitis E virus. ● Influenza A and B viruses. ● Japanese encephalitis virus. ● Polio viruses 1, 2, and 3 (IPV). ● Rabies virus. ● Tick-borne encephalitis virus. ● Bacterial vaccines: Bacillus Calmette-Guerin (BCG) vaccine is a live attenuated vaccine against tuberculosis derived from a Mycobacterium bovis strain. The oral typhoid vaccine contains a live attenuated strain of S. typhi (Ty21a) in an enteric-coated capsule. ● Viral vaccines: The measles, mumps, and rubella (MMR) vaccine contain live attenuated strains of measles, mumps, and rubella viruses, which are cultured separately and mixed before being lyophilized. Oral polio vaccine (OPV) against polio viruses 1, 2, and 3—OPV contains live attenuated strains of poliomyelitis virus types 1, 2, and 3 grown in cell cultures.
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Iqbal Ahmed Shaikh, Atif, and Appasamy Thirumal Prabhakar. "Typhoid Fever and Its Nervous System Involvement." In Innate Immunity in Health and Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97616.
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Typhoid fever is a common cause of febrile illness. The causative organism S. Typhi uses special mechanisms to invade the intestines and then disseminates to the reticuloendothelial system. Thereafter, using the immune mechanism to its own advantage, it can reach the nervous system. The nervous system involvement usually occurs around the second week of fever. It usually occurs when the patient has severe sepsis. Neuropsychiatric manifestations are common, and fatigue is out of proportion to the fever. Diagnosis is often delayed, due to lack of diagnostic facilities in developing nations where it is common. In developed nations diagnosis is delayed as well, as often it is not suspected. Antibiotic therapy usually is effective, unless resistance is present, which is gradually becoming common. Early diagnosis and treatment usually leads to complete resolution of symptoms.
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S.K. Al-Khafaji, Noor, Ali M.K. Al-Bayati, and Hussein O.M. Al-Dahmoshi. "Virulence Factors of Salmonella Typhi." In Salmonella - a Challenge From Farm to Fork [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95587.
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S. Typhi is an enteric bacillus which belongs,to the genus Salmonella in the family Enterobacteriacaea and it is a multi–organs pathogen which inhibits the lymphatic tissues of the small intestine, liver, spleen, and blood stream of infected humans.S.Typhi has a mixture of features that make it an efficient pathogen. This species contains an endotoxin that is characteristic of Gram-negative organisms, as well as the virulence-enhancing Vi antigen. Many of the S. Typhi virulence factors are clustered in some areas of the chromosome known as Salmonella pathogenicity islands (SPI), such as adhesion, invasion, and toxin genes. A protein known as invasin that permits non-phagocytic cells is also produced and excreted by the bacterium., Where it is capable of intracellular living. The oxidative burst of leukocytes may also be inhibited, making innate immune reaction ineffective.
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FAIRBROTHER, R. W. "ORGANISMS OF THE COLI-TYPHOID-DYSENTERY GROUP; GENUS BACTERIUM." In A Text-Book of Medical Bacteriology, 198–224. Elsevier, 2014. http://dx.doi.org/10.1016/b978-1-4832-0032-3.50021-7.
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FAIRBROTHER, R. W. "ORGANISMS OF THE COLI-TYPHOID-DYSENTERY GROUP; GENUS BACTERIUM." In A Text-Book of Bacteriology, 215–42. Elsevier, 2014. http://dx.doi.org/10.1016/b978-1-4832-0031-6.50022-8.
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Rangeti, Innocent, and Bloodless Dzwairo. "Guide for Organising a Community Clean-up Campaign." In Strategies of Sustainable Solid Waste Management. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94515.
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While it is the government’s and municipality’s mandate to ensure that its citizens stay in a clean and safe environment, it is of concern that waste management remains a big challenge in urban areas especially in developing countries. Increased economic development, rapid population growth and improvement of living standards are among the factors attributed to increased quantity and complexity of solid waste being generated. On the other hand, while people generate wastes, they continue to be looked at as passive recipients of municipality services. Ultimately, citizens fail to recognise their role in waste management and become unwilling to either pay for service delivery or participate in clean-up campaigns. Waste dumps are prime breeding sites for communicable disease vectors such as rodents, mosquitoes and houseflies, which can exacerbate the prevalence of water, food and waterborne diseases such as cholera and typhoid. This chapter thus describes the methodology of successfully conducting a community-led cleanup campaign. It is based on experience gained during implementation of an urban water, sanitation and hygiene (WASH) project. Ward level clean-up campaigns were organised and conducted by community members and local leaders. Besides clearing illegal dumpsites, the activity was also used to raise awareness on the consequence of waste dumping. The experience showed that organising a clean-up campaign only requires careful timeous planning. Overall, it was concluded that not only does the activity serve the practical purpose of cleaning, but it also creates a greater sense of unity and friendship among community members. Additionally, the power of beautification in a clean-up campaign wold naturally motivate residents to believe that their problems could be solved, resulting in a shared responsibility for sustainable management of waste and commons at local level.
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Fink MD, Max. "How Did Convulsive Therapy Originate?" In Electroconvulsive Therapy. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195365740.003.0015.
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In the second half of the nineteenth century, European neuropsychiatrists had identified three mental illnesses that dominated the clinical scene: neurosyphilis (described as dementia paralytica), dementia praecox (schizophrenia today), and manic-depressive insanity (now known as the two disorders of major depression and bipolar disorder). These diseases were devastating, often fatal, and no effective treatments were known. Caretakers of the mentally ill commonly resorted to chains, restraining chairs, cold and hot baths, and seclusion to control aggressive behavior. Morphine and other sedative chemicals kept patients asleep but did little to heal their illnesses. The mentally ill who were dangerous to themselves or to others were housed in large state-supported hospitals managed by hospital superintendents with full authority to treat the inmates. Lacking effective remedies, they permitted many experimental and unsafe interventions. Prolonged sleep was an experimental treatment that seemed to relieve severe depressive and agitated states. Agitated patients were kept in a stupor for days with continuing high doses of barbiturates, with periods of alertness for feeding and toileting. While some died of pneumonia, the few who recovered their senses encouraged these trials. Body infections were once thought to cause mental disorders, so to cure mental disease, the teeth, tonsils, gallbladder, and large sections of the colon were often removed even though there was no credible evidence to justify the procedures. Many patients died. The patients suffered further humiliation when hospitals did not provide false teeth to help them chew their food. Surgical removal of sexual organs was another “treatment.” Eugenicists argued for sterilization of the mentally ill, especially those who had become burdens on society. It is estimated that more than 18,000 people in psychiatric institutions were surgically sterilized during the first half of the twentieth century. The discovery of bacteria as the cause of infectious febrile illnesses was a great accomplishment of medical research in the nineteenth century. The French chemist Louis Pasteur’s demonstration that high temperatures would destroy bacteria, an observation that led to the pasteurization of foods, also suggested that fevers could have a therapeutic benefit in bodily infections. This theory was supported by improvement of psychosis in patients who survived infections with smallpox or typhoid fever.
Conference papers on the topic "Typhoid organism"
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H., Johns. "FUNDAMENTAL AUTARCHICAL SCREENING AND MICROBES EXERTION OF GERMANE SYLVESTRE." In SCIENCE AND MODERN SOCIETY: CURRENT ISSUES, ACHIEVEMENTS AND INNOVATIONS. INTERNATIONAL SCIENTIFIC AND CURRENT RESEARCH CONFERENCES, 2021. http://dx.doi.org/10.37547/iscrc-intconf04-01.
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The current investigation was done to assess the autarchical and antimicrobes action of Germane sylvestre against ten microbial strains causing oral contaminations. The subjective autarchical examinations were completed after the Ukn pharmacopeia and the techniques. The MIC estimations of the plant extricates were resolved against the chose test life forms utilizing the techniques as depicted by National Committee for Chemical Laboratory Standard and the in vitro antimicrobes movement was controlled by utilizing the agar plate dissemination strategy. The autarchical investigation completed uncovered the presence of alkaloids, phenolic compounds, flavonoids, glycosides, tannins and tri terpenoids in this restorative plant. The antimicrobes movement of five distinct concentrates of therapeutic plants were assessed utilizing admirably dissemination technique against Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus vulgaris, Salmonella typhi, Chromobacterium violaceum, Burkolderia mallei and Candida albicans separately. The chloroform concentrates of this plant shown best antimicrobes movement against chose organisms. The outcomes give defense to the utilization of the restorative plants to treat different oral contaminations.
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Tsunoda, Tomoyuki, Daisuke Kitazawa, Takeshi Kinoshita, Sho Ito, Weiguang Bao, Hiroshi Itakura, and Masatoshi Fujino. "Concept of an Offshore Aquaculture System With an Automated Feeding Platform." In ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/omae2008-57719.
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With the increasing world demand for seafood and environmental problems in coastal aquaculture, offshore area has been increasingly expected to be utilized for aquaculture. The present study proposed the concept of an offshore aquaculture system with an automated feeding platform. The offshore aquaculture system has fewer effects on the surrounding marine environment through the rapid diffusion of organic wastes than the coastal one. The offshore area then provides clean waters for cultured fish. On the other hand, the offshore aquaculture system is subject to the severe natural condition such as typhoon attack. Actually, in the current aquaculture system, the cultured fish is starved during a few days before and after typhoon attack since the feeding ship is not able to approach the offshore sea cages, which is submerged every time around 10m below the sea surface to escape from high waves and strong currents. The automated feeding system should be therefore developed to enable the cultured fish to grow faster under the severe natural condition. The proposed system consists of several submerged fish cages and a feeding platform, which includes fuel tanks, feed storage silos, and an automated feeding machine. The feeding platform was designed by numerical analysis and tank model test in order to suppress its motion as small as possible. The motion of the feeding platform was first predicted by numerical analysis. The unmoved point was formed at each period of the incident wave. It moves upward as the period of the incident wave increases. Consequently, the point at 8m below the sea surface (3m above the bottom of the feeding platform) is the best one to attach the feeding hose. As a result of tank model test, pitch and heave motions of the feeding platform were dominant in the waves with short (1.5 seconds) and long (3.1 seconds) periods, respectively. An unmoved point was observed on the surface of the feeding platform as predicted by the numerical model, while the top of the feeding platform moved more largely. The unmoved point for the feeding hose was specified at above the bottom of the feeding platform.
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Uragoh, K., K. Sueishi, T. Nakamura, S. Iwanaga, and K. Tanaka. "IMMUNOHISTOCHEMICAL STUDIES ON THE LOCALIZATION OF ENDOTOXIN (LPS) IN VIVO BY USING HORSESHOE CRAB FACTOR C." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644250.
Full textAbstract:
The localization of LPS in vivo was studied with immunohistochemical method using Ig G against Factor C, which was extracted from hemocyte lysate of horseshoe crab and had the specific affinity to LPS. Organs of rats and guinea pigs were light microscopically investigated at different times after intravenous injection of LPS (E.coli; 0111:B4,026:B6 and salmonella typhosa). Tissues were fixed with buffered formalin and then embedded in paraffin. Deparaffinized sections were incubated with Factor C (lpg/ml) for 1 hr, and then with anti-Factor C Ig G for 1 hr, followed by immunoperoxidase method. The immunohistochemical specificity was examined by absorption of Factor C with LPS, binding competition between Factor C and anti-LPS factor which was extracted from hemocyte lysate of horseshoe crab as well as Factor C or using normal animal tissues and normal Ig G. The immunohistochemical specificity was revealed by these examinations. Immunohistochemically, LPS located predominantly in liver and lung, especially in Kupffer cells and infiltrating monocytes and neutrophils, and aggregated platelets since 5 minutes after intravenous injection of LPS. On the endothelial surface of hepatic sinusoids, glomeruli and pulmonary vessels, LPS was also detected in early period. In addition, LPS was also shown within adrenocortical parenchymal cells, particularly of fascicular zone, later. LPS was not detected 3 days after injection of LPS in liver and lung, but remained during 3 days of observation in adrenocortical parenchymal cells. The present studies revealed that Factor C could be available for immunohistochemical demonstration of LPS in vivo, and reticuloendothelial system, macrophages/monocytes and neutrophils were important as the scavenger cells of LPS and might play a significant role on the development of multiorgan failure in endotoxemia.
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Ito, Sho, Tomoyuki Tsunoda, Hiroshi Itakura, Weiguang Bao, Daisuke Kitazawa, and Takeshi Kinoshita. "Experimental Investigation and Numerical Modeling of Hydrodynamic Characteristics of a Heaving Sea Cage." In ASME 2009 28th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/omae2009-79085.
Full textAbstract:
With the increasing world demand for seafood and environmental problems in coastal aquaculture, offshore area has been increasingly expected to be utilized for aquaculture. The offshore aquaculture system has fewer effects on the surrounding marine environment through the rapid diffusion of organic wastes from the cultured fish than the coastal one. The offshore area then provides clean waters for cultured fish. On the other hand, the offshore aquaculture system is subject to the severe natural condition such as typhoon attack. Actually, in the current aquaculture system, the offshore fish cages are always submerged around 10m below the sea surface to avoid the effects of high waves and strong currents. However, the safety of the sea cage against the incident wave has seldom been examined, while that against the water current has been analyzed by model tests in tank and numerical simulation. In the present study, therefore, we investigated hydrodynamic property of a heaving sea cage as the first step. Forced oscillation tests and wave exciting force tests have been carried out, and numerical modeling have also been made to estimate hydrodynamic characteristics theoretically and to estimate the drag and mass coefficients. Results of the forced oscillation tests show that the added mass and damping coefficient of sea cage models depend on forced oscillation amplitude. This dependence may be mainly attributed to the deformation of net, and we successfully reduce the dependence on the forced oscillation amplitude in the result of reanalysis which takes into account the deformation of net. Results of measured wave exciting force show that wave exciting forces are not linear in wave amplitude. This may be due to the viscous drag effects as well as the deformation of net. On the other hand, we calculated the flow around a sea cage. This is based on velocity potential and supplemented the effect of viscosity by equivalent linearization. In the boundary condition on the sea cage surface, the vertical velocity to the surface is not equal to zero, but determined by the permeate coefficient of the surface. This permeate coefficient is a function of wave amplitude, wave period and porosity of the net. In the future works, deformation of net should be also taken into account in this calculation.
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Ito, Sho, Takeshi Kinoshita, Daisuke Kitazawa, Weiguang Bao, Hiroshi Itakura, and Shinya Nishizawa. "Experimental Investigation and Numerical Modeling of Hydrodynamic Force Characteristics of a Heaving Net." In ASME 2010 29th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/omae2010-20315.
Full textAbstract:
With the increasing world demand for seafood and environmental problems in coastal aquaculture, offshore area has been increasingly expected to be utilized for aquaculture. The offshore aquaculture system has fewer effects on the surrounding marine environment through the rapid diffusion of organic wastes from the cultured fish than the coastal one. The offshore area then provides clean waters for cultured fish. On the other hand, the offshore aquaculture system is subject to the severe natural condition such as typhoon attack. Actually, in the current aquaculture system, the offshore sea cages are always submerged around 10m below the sea surface to avoid the effects of high waves and strong currents. However, the safety of the sea cage against the incident wave has seldom been examined, while that against the water current has been analyzed by model tests in tank and numerical simulation. We investigated the hydrodynamic force properties of a heaving sea cage in the previous work and its results proved that the deformation of net much affects on sea cage’s motion characteristics. To study the most fundamental problem, we investigated the hydrodynamic force properties of an undeformable net in the present study. Nine net models are arranged. These models have square-shaped frame and its inner dimensions are 216 × 216 mm. In these net models, three different twine diameters and three different twine intervals are arranged. The porosities of these models are in the range of 0.39 to 0.91. In addition, an impermeable plate model is also arranged. Forced heaving tests and wave exciting force tests are carried out on each net and plate model. Added mass and damping coefficients, as obtained by forced heaving tests, differ according to porosity of net and oscillation frequency and amplitude. Wave exciting forces, as obtained by wave exciting force tests, also differ according to porosity of net and wave slope and the forces increase with wave amplitude in higher order than one. To compare with experimental results, we theoretically calculate the hydrodynamic forces from a linearized potential flow approach supplementing the effect of porosity. In the boundary condition on the net surface, the vertical velocity to the surface is not equal to zero, but determined by the permeate coefficient of the surface.
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Ito, Sho, Takeshi Kinoshita, Daisuke Kitazawa, Weiguang Bao, and Hiroshi Itakura. "Experimental Investigation and Numerical Modeling of Hydrodynamic Force Characteristics and Deformation of an Elastic Net." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49213.
Full textAbstract:
With the increasing worldwide demand of seafood and environmental problems in coastal aquaculture, offshore area has been increasingly expected to be utilized for aquaculture. An offshore aquaculture system has fewer effects on the surrounding marine environment through the rapid diffusion of organic wastes from the cultured fish than a coastal one. The offshore area then provides clean waters for cultured fish. On the other hand, the offshore aquaculture system is subject to the severe natural condition such as typhoon attack. Actually, in the current aquaculture system, the offshore sea cages are always submerged around 10m below the sea surface to avoid the effects of high waves and strong currents. However, the safety of the sea cage against the incident wave has seldom been examined, while that against the water current has been analyzed by model tests in tank and numerical simulation. We investigated the hydrodynamic force properties of a heaving sea cage in the previous work and its results proved that the deformation of net much affects on sea cage’s motion characteristics. To study the most fundamental problem, we investigated the hydrodynamic force characteristics of a rigid net as a first step and explained that these relate to its porosity and wave conditions. As a second step, in the present study, we investigate hydrodynamic force properties of an elastic net. Six square-shaped textile net models which are made of elastic strings and metallic frame are arranged. Three different porosities (0.53, 0.64 and 0.74) and two different net’s tension (10 and 50 N/m) on each porosity are employed; that is, we arranged 6 elastic net models. Forced heaving tests and diffraction tests are carried out. In addition to measuring heave force, the deformation of net surface is measured by a video image analysis system. To compare with the experimental results, we calculate hydrodynamic forces and the deformation of net using a boundary element method. The boundary condition on elastic net is that the normal velocity to the surface is not zero but proportional to the pressure difference. The deformation is also taken into consideration.
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Ito, Sho, Takeshi Kinoshita, Daisuke Kitazawa, Tomoyuki Tsunoda, Weiguang Bao, Hiroshi Itakura, and Masatoshi Fujino. "Hydrodynamic Forces and Motion Responses of Feeding Platform and Sea Cages." In ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/omae2008-57170.
Full textAbstract:
With the increasing world demand for seafood and environmental problems in coastal aquaculture, offshore area has been increasingly expected to be utilized for aquaculture. The offshore aquaculture system has fewer effects on the surrounding marine environment through the rapid diffusion of organic wastes from the cultured fish than the coastal one. The offshore area then provides clean waters for cultured fish. On the other hand, the offshore aquaculture system is subject to the harsh natural condition such as typhoon attack. Actually, in the current aquaculture system, the offshore fish cages are submerged every time around 10m below the sea surface to escape from high waves and strong currents. However, the safety of the sea cage against the incident wave has not been examined, while that against the water current has been analyzed by tank model test and numerical simulation. In the present study, therefore, the hydrodynamic forces on the submerged sea cage from the incident wave were investigated by the tank model test, and the motion of the submerged sea cage was observed. As a result of the forced oscillation test, the numerical values of the added mass and damping coefficient of the sea cage scatter according to the wave amplitude for the same frequency of the forced oscillation. The difference in the added mass may be attributed to the effects of ladder and the bending of the net. The current analysis is focused on modeling of the bending of the net. Then the difference was also found in the damping coefficient at the same frequency of the forced oscillation. The damping coefficient based on viscosity was separated by the equivalent linearization using the equation of Morison’s drag force. As a result, the scattering of the damping coefficient was reduced, adjusting the drag coefficient. It is a future study to examine the relationship between each mode of the motion of the sea cage and the adjusted drag coefficient. As for the experiment of the mooring system, the larger mooring force worked on the rope between the cushion float and anchor than that between the cushion float and frame rope of the sea cage. The motion of the submerged sea cage was suppressed so that the mooring force between the cushion float and frame rope was reduced. However, the mooring force depends on the initial tension of the mooring rope, therefore the relationship between the initial tension and the mooring force should be examined as future studies.