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Journal articles on the topic 'Tyramine'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Hopman, Anton H. N., Frans C. S. Ramaekers, and Ernst J. M. Speel. "Rapid Synthesis of Biotin-, Digoxigenin-, Trinitrophenyl-, and Fluorochrome-labeled Tyramides and Their Application for In Situ Hybridization Using CARD Amplification." Journal of Histochemistry & Cytochemistry 46, no. 6 (1998): 771–77. http://dx.doi.org/10.1177/002215549804600611.

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A one-step procedure for the synthesis of different tyramide conjugates, which can be utilized in the catalyzed reporter deposition (CARD) amplification system, is described. Succinimidyl esters of biotin, digoxigenin, and of the fluorochromes fluorescein, rhodamine, aminomethylcoumarine acetic acid, and Cy3 were coupled to tyramine in dimethylformamide (DMF) adjusted to a pH of 7.0–8.0 with triethylamine (TEA). The coupling reaction can be performed within 2 hr and the reaction mixture can be applied without further purification steps. Furthermore, trinitrophenyl (TNP)-tyramide was prepared b

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2

Pawestri, Setyaning, and Fathma Syahbanu. "Kajian Senyawa Tiramin dalam produk Olahan: Kajian Literatur." Jurnal Teknologi dan Industri Pertanian Indonesia 16, no. 1 (2024): 44–53. http://dx.doi.org/10.17969/jtipi.v16i1.31391.

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Recently, food safety issues can be affected by several bioactive compounds such as biogenic amines that can be specifically found in fermented foods due to bacterial decarboxylation of some amino acids by fermentation or spoilage bacteria. Tiramin is a biogenic amine produced through decarboxylation of the amino acid tyrosine in animals, plants and microorganisms. Tiramin can cause adverse health effects, such as histamine and tyramine poisoning, histamine and tyraminentolerance, or hypertensive crisis caused by the interaction between tyramine and monoamine oxidase inhibitor drugs. Tiramin i

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3

IZQUIERDO-PULIDO, MARIA, JUDIT FONT-FÀBREGAS, JOSEP-MIQUEL CARCELLER-ROSA, ABEL MARINÉ-FONT, and CARMEN VIDAL-CAROU. "Biogenic Amine Changes Related to Lactic Acid Bacteria During Brewing." Journal of Food Protection 59, no. 2 (1996): 175–80. http://dx.doi.org/10.4315/0362-028x-59.2.175.

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Biogenic amine contents and microbial contamination (wild yeasts and lactic acid bacteria) were followed during beer fermentation in both industrial and pilot plants. No significant change in the amine contents was observed, except for tryptamine and tyramine. Tyramine formation showed a great variability (from 8 to almost 30 mg/l), while tryptamine formation was always much lower than tyramine (&lt;3.5 mg/l). No relationship was found between wild yeast counts and tyramine formation, whereas a significant positive relationship was found between tyramine formation and lactic acid bacteria.

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IZQUIERDO-PULIDO, MARIA, JOSEP-MIQUEL CARCELLER-ROSA, ABEL MARINÉ-FONT, and M. CARMEN VIDAL-CAROU. "Tyramine Formation by Pediococcus spp. during Beer Fermentation." Journal of Food Protection 60, no. 7 (1997): 831–36. http://dx.doi.org/10.4315/0362-028x-60.7.831.

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The role of Pediococcus spp. in the production of tyramine was studied. Strains of these microorganisms were isolated from industrial beer fermentations where high tyramine formation occurred. It has been verified that Pediococcus spp. are able to form tyramine during beer fermentation, and the quantity of tyramine produced depends on the degree of contamination. Thus, CFU of Pediococcus spp. ranging from 4 ×103 to 1 × 104 CFU/ml led to low tyramine formation (&lt;5 mg/liter). Tyramine production between 5 and 15 mg/liter was related to Pediococcus spp. counts from 1 × 104 to 5 × 104 CFU/m

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5

Park, Young Kyoung, Young Hun Jin, Jun-Hee Lee, et al. "The Role of Enterococcus faecium as a Key Producer and Fermentation Condition as an Influencing Factor in Tyramine Accumulation in Cheonggukjang." Foods 9, no. 7 (2020): 915. http://dx.doi.org/10.3390/foods9070915.

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The study evaluated the role of Enterococcus faecium in tyramine production and its response to fermentation temperature in a traditional Korean fermented soybean paste, Cheonggukjang. Tyramine content was detected in retail Cheonggukjang products at high concentrations exceeding the recommended limit up to a factor of 14. All retail Cheonggukjang products contained Enterococcus spp. at concentrations of at least 6 Log CFU/g. Upon isolation of Enterococcus strains, approximately 93% (157 strains) produced tyramine at over 100 µg/mL. The strains that produced the highest concentrations of tyram

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6

Varma, Daya R., Xing-Fei Deng, Sylvain Chemtob, Francois Nantel, and Michel Bouvier. "Characterization of the vasorelaxant activity of tyramine and other phenylethylamines in rat aorta." Canadian Journal of Physiology and Pharmacology 73, no. 6 (1995): 742–46. http://dx.doi.org/10.1139/y95-097.

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We recently reported that tyramine caused concentration-dependent relaxation of rat aorta, which was endothelium independent and was not exerted via α1-adrenoceptors (AR), α2AR, β1AR, β2AR, or receptors for 5-hydroxytryptamine, histamine, and adenosine. The present studies were done on endothelium-denuded strips to determine structure – vasorelaxant activity after blockade of βAR by propranolol plus irreversible blockade of α1AR with benextramine. Vasorelaxation under these conditions was limited to noncatecholamines, and their vasorelaxant potencies were methoxyphenamine > tyramine > p-

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7

Dhakal, Sudip, and Ian Macreadie. "Tyramine and Amyloid Beta 42: A Toxic Synergy." Biomedicines 8, no. 6 (2020): 145. http://dx.doi.org/10.3390/biomedicines8060145.

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Implicated in various diseases including Parkinson’s disease, Huntington’s disease, migraines, schizophrenia and increased blood pressure, tyramine plays a crucial role as a neurotransmitter in the synaptic cleft by reducing serotonergic and dopaminergic signaling through a trace amine-associated receptor (TAAR1). There appear to be no studies investigating a connection of tyramine to Alzheimer’s disease. This study aimed to examine whether tyramine could be involved in AD pathology by using Saccharomyces cerevisiae expressing Aβ42. S. cerevisiae cells producing native Aβ42 were treated with d

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8

Blumenthal, Edward M. "Regulation of chloride permeability by endogenously produced tyramine in the Drosophila Malpighian tubule." American Journal of Physiology-Cell Physiology 284, no. 3 (2003): C718—C728. http://dx.doi.org/10.1152/ajpcell.00359.2002.

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The Malpighian (renal) tubule of Drosophila melanogaster is a useful model for studying epithelial transport. The purpose of this study was to identify factors responsible for modulating transepithelial chloride conductance in isolated tubules. I have found that tyrosine and several of its metabolites cause an increase in chloride conductance. The most potent of these agonists is tyramine, which is active at low nanomolar concentrations; the pharmacology of this response matches that of the previously published cloned insect tyramine receptor. In addition, the tubule appears capable of synthes

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9

Fernández, María, Ana Belén Flórez, Daniel M. Linares, Baltasar Mayo, and Miguel A. Alvarez. "Early PCR detection of tyramine-producing bacteria during cheese production." Journal of Dairy Research 73, no. 3 (2006): 318–21. http://dx.doi.org/10.1017/s0022029906001750.

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Biogenic amines (BA) are toxic substances that appear in foods and beverages. Tyramine is the most abundant BA in cheeses. A PCR method was developed to detect the presence of tyramine-producing bacteria during cheese manufacture and ripening. Six different batches of a farmhouse blue cheese were analysed by PCR. Tyramine concentrations were also determined by HPLC. The PCR method was able to anticipate tyramine accumulation in the cheeses; the presence of tyramine-producing microorganisms in the early stages of manufacture correlated well with a high concentration of BA in mature cheese sampl

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10

LIU, FANG, XINXIN WANG, LIHUI DU, et al. "Effect of NaCl Treatments on Tyramine Biosynthesis of Enterococcus faecalis." Journal of Food Protection 78, no. 5 (2015): 940–45. http://dx.doi.org/10.4315/0362-028x.jfp-14-443.

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The effect of NaCl stress (0 to 8%, wt/vol) on the growth and tyramine production in two Enterococcus faecalis strains was examined during culture time. The growth of E. faecalis was inhibited by the increase in NaCl concentration, but tyramine production was unaffected. Tyramine accumulated rapidly during the logarithmic phase of the strains, and the final tyramine levels were approximately 800 μg/ml. Relative gene expression of four genes in the tyrosine decarboxylase locus, namely, tyrRS, tyrDC, tyrP, and nhaC, was evaluated at different incubation times. The results showed that NaCl stress

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11

Anderegg, Janine, Florentin Constancias, and Leo Meile. "Effects of Sodium Chloride on Tyramine Production in a Fermented Food Model and its Inhibition by Tyrosine-degrading Lactobacillus plantarum JA-1199." CHIMIA International Journal for Chemistry 74, no. 5 (2020): 391–97. http://dx.doi.org/10.2533/chimia.2020.391.

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Tyramine is a health-adverse biogenic amine, which can accumulate in fermented foods like cheese by decarboxylation of the free amino acid tyrosine by either starter cultures or resident microbes such as lactic acid bacteria including Enterococcus spp., respectively. Our study aimed to show the effect of sodium chloride concentrations on tyramine production as well as to characterise bacterial strains as anti-tyramine biocontrol agents in a 2 mL micro-cheese fermentation model. The effect of sodium chloride on tyramine production was assayed with tyramine producing strains from eight different

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12

FERNÁNDEZ, MARÍA, DANIEL M. LINARES, and MIGUEL A. ALVAREZ. "Sequencing of the Tyrosine Decarboxylase Cluster of Lactococcus lactis IPLA 655 and the Development of a PCR Method for Detecting Tyrosine Decarboxylating Lactic Acid Bacteria." Journal of Food Protection 67, no. 11 (2004): 2521–29. http://dx.doi.org/10.4315/0362-028x-67.11.2521.

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The enzymatic decarboxylation of tyrosine produces tyramine, the most abundant biogenic amine in dairy products—especially in cheeses. The screening of lactic acid bacteria isolated from different artisanal cheeses and a number of microbial collections identified 22 tyramine-producing strains belonging to different genera. The Lactococcus lactis strain IPLA 655 was selected, and the genes encoding a putative tyrosyl tRNA synthetase, a tyrosine decarboxylase (tdcA), and a tyrosine-tyramine antiporter, found together as a cluster, were sequenced. The disruption of tdcA yielded a strain unable to

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13

Schützler, Natalie, Chantal Girwert, Isabell Hügli, et al. "Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state." Proceedings of the National Academy of Sciences 116, no. 9 (2019): 3805–10. http://dx.doi.org/10.1073/pnas.1813554116.

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Adrenergic signaling profoundly modulates animal behavior. For example, the invertebrate counterpart of norepinephrine, octopamine, and its biological precursor and functional antagonist, tyramine, adjust motor behavior to different nutritional states. In Drosophila larvae, food deprivation increases locomotor speed via octopamine-mediated structural plasticity of neuromuscular synapses, whereas tyramine reduces locomotor speed, but the underlying cellular and molecular mechanisms remain unknown. We show that tyramine is released into the CNS to reduce motoneuron intrinsic excitability and res

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14

Fernández de Palencia, Pilar, Maria Fernández, Maria Luz Mohedano, et al. "Role of Tyramine Synthesis by Food-BorneEnterococcus duransin Adaptation to the Gastrointestinal Tract Environment." Applied and Environmental Microbiology 77, no. 2 (2010): 699–702. http://dx.doi.org/10.1128/aem.01411-10.

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ABSTRACTBiogenic amines in food constitute a human health risk. Here we report that tyramine-producingEnterococcus duransstrain IPLA655 (from cheese) was able to produce tyramine under conditions simulating transit through the gastrointestinal tract. Activation of the tyramine biosynthetic pathway contributed to binding and immunomodulation of enterocytes.

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15

Schilcher, Felix, Markus Thamm, Martin Strube-Bloss, and Ricarda Scheiner. "Opposing Actions of Octopamine and Tyramine on Honeybee Vision." Biomolecules 11, no. 9 (2021): 1374. http://dx.doi.org/10.3390/biom11091374.

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The biogenic amines octopamine and tyramine are important neurotransmitters in insects and other protostomes. They play a pivotal role in the sensory responses, learning and memory and social organisation of honeybees. Generally, octopamine and tyramine are believed to fulfil similar roles as their deuterostome counterparts epinephrine and norepinephrine. In some cases opposing functions of both amines have been observed. In this study, we examined the functions of tyramine and octopamine in honeybee responses to light. As a first step, electroretinography was used to analyse the effect of bot

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16

Blumenthal, Edward M. "Modulation of tyramine signaling by osmolality in an insect secretory epithelium." American Journal of Physiology-Cell Physiology 289, no. 5 (2005): C1261—C1267. http://dx.doi.org/10.1152/ajpcell.00026.2005.

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The control of water balance in multicellular organisms depends on absorptive and secretory processes across epithelia. This study concerns the effects of osmolality on the function of the Malpighian tubules (MTs), a major component of the insect excretory system. Previous work has shown that the biogenic amine tyramine increases transepithelial chloride conductance and urine secretion in Drosophila MTs. This study demonstrates that the response of MTs to tyramine, as measured by the depolarization of the transepithelial potential (TEP), is modulated by the osmolality of the surrounding medium

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17

LYTE, MARK. "The Biogenic Amine Tyramine Modulates the Adherence of Escherichia coli O157:H7 to Intestinal Mucosa." Journal of Food Protection 67, no. 5 (2004): 878–83. http://dx.doi.org/10.4315/0362-028x-67.5.878.

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The environmental factors that influence the ability of Escherichia coli O157:H7 to attach to the intestinal mucosa are incompletely understood. In the present study, the ability of one of the most common biogenic amines present in food, tyramine, to influence the ability of E. coli O157:H7 to adhere to murine cecal mucosa was examined. Ex vivo full-thickness sheets of murine cecum were mounted in Ussing chambers, which preserved the enteric nervous system innervation of the luminal epithelia and thereby allowed us to achieve a closer approximation of bacterial adherence than would be encounte

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18

Luliński, Piotr, Marta Janczura, Monika Sobiech, and Joanna Giebułtowicz. "Magnetic Molecularly Imprinted Nano-Conjugates for Effective Extraction of Food Components—A Model Study of Tyramine Determination in Craft Beers." International Journal of Molecular Sciences 22, no. 17 (2021): 9560. http://dx.doi.org/10.3390/ijms22179560.

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In this paper, magnetic molecularly imprinted nano-conjugates were synthesized to serve as selective sorbents in a model study of tyramine determination in craft beer samples. The molecularly imprinted sorbent was characterized in terms of morphology, structure, and composition. The magnetic dispersive solid phase extraction protocol was developed and combined with liquid chromatography coupled with mass spectrometry to determine tyramine. Ten samples of craft beers were analyzed using a validated method, revealing tyramine concentrations in the range between 0.303 and 126.5 mg L−1. Tyramine l

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19

Trivedi, K., I. Borkovcová, and R. Karpíšková. "Tyramine Production by Enterococci from Various Foodstuffs: A Threat to the Consumers." Czech Journal of Food Sciences 27, Special Issue 1 (2009): S357—S360. http://dx.doi.org/10.17221/934-cjfs.

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Tyramine is the most frequent biogenic amine found in cheese and is also frequently found in other fermented foods and beverages. In total 273 different strains of enterococci from various foodstuffs were studied. A multiplex PCR was designed for the genotypic differentiation of various enterococci strains at species level and for determination of the presence of tyramine producing (<I>tyrdc</I>) gene. <I>E. faecali</I>s and <I>E. faecium</I> were found to be prominent strains in dairy and meat products while, <I>E. faecium</I> and <I>E. mu

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20

Grabowski, Szymon, Klaudia Nowakowska, Helena Butkiewicz, et al. "Additive-driven microwave crystallization of tyramine polymorphs and salts: a quantum crystallography perspective." IUCrJ 12, no. 3 (2025): 403–16. https://doi.org/10.1107/s2052252525002210.

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Polymorphism – the ability of a compound to exist in multiple crystalline forms – needs to be carefully considered in the design of functional materials, particularly in the context of cocrystallization. Tyramine, a biogenic amine, is a promising candidate for polymorph exploration due to its conformational flexibility and ability to form salts. In this study, we investigate the crystallization of tyramine polymorphs using additives and microwave-assisted techniques. Our findings reveal the formation of a new tyramine polymorph and two distinct salts, highlighting the impact of microwave radia

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21

Ndione, Papa Adama, Moussa Mbaye, Latyr Ndione, et al. "New Method for Analyzing Tyramine by Spectrofluorimetry: Application to Fish." International Journal of Chemistry 16, no. 1 (2023): 22. http://dx.doi.org/10.5539/ijc.v16n1p22.

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A new method for direct spectrofluorimetric analysis of tyramine in various fish samples was established. Low limits of detection (LOD) between 0.53 ng/mL and 1.40 ng/mL and limits of quantification (LOQ) between 1.76 ng/mL and 4.68 ng/mL were obtained. Also, low values of relative standard deviations (RSD) between 0.30 % and 0.58 % were obtained; confirming good reproducibility of our measurements. The application of this method to our samples allowed the detection of tyramine with satisfactory recovery rates between 93.68 % and 106.60 %. Interference studies with different biogenic amines ha

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22

Kim, Seok Hyung, Young Kee Shin, Kyung Mee Lee, Jung Sun Lee, Ji Hye Yun, and Sun Myung Lee. "An Improved Protocol of Biotinylated Tyramine-based Immunohistochemistry Minimizing Nonspecific Background Staining." Journal of Histochemistry & Cytochemistry 51, no. 1 (2003): 129–32. http://dx.doi.org/10.1177/002215540305100116.

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An immunohistochemical method using biotinyl tyramine was recently introduced to amplify weak staining signals. Despite its high sensitivity, however, tyramine-based immunostaining has been limited by its increased background staining. In this study, to develop an improved protocol of biotinyl tyramine-based immunohistochemistry minimizing the background staining, we determined which staining steps lead to the nonspecific reaction and the most appropriate blocking agents for background-provoking steps. Trypton casein peptone and distilled water with Tween-20 were shown to be most effective as

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23

Shimomura, Tokio, and Kazuro Takahashi. "Pupillary Functional Asymmetry in Patients With Muscle Contraction Headache." Cephalalgia 6, no. 3 (1986): 141–45. http://dx.doi.org/10.1046/j.1468-2982.1986.0603141.x.

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Twenty-five patients with ‘muscle contraction headache’ (MCH) underwent tyramine papillary tests, and 15 of them also underwent physiologic pupillary tests and cold pressor tests. Twenty healthy controls underwent tyramine pupillary tests, physiologic pupillary tests, and cold pressor tests. In the tyramine papillary tests and the physiologic papillary tests, the controls showed a symmetric mydriasis. In contrast, MCH patients showed asymmetric mydriasis after tyramine instillation and in the physiologic pupillary tests. In the cold pressor tests MCH patients reacted in the same manner as the

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24

Danilov, D. S., and M. Yu Brovko. "Evolution of ideas about the risk of tyramine syndrome developing during therapy with irreversible non-selective monoamine oxidase inhibitors (to the 70th anniversary of the first use of this group of antidepressants)." Neurology, Neuropsychiatry, Psychosomatics 14, no. 5 (2022): 4–12. http://dx.doi.org/10.14412/2074-2711-2022-5-4-12.

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We describe the history of studying of the problem of tyramine syndrome during the treatment with antidepressants, irreversible non-selective monoamine oxidase inhibitors. Data on clinical observations are presented. Early hypotheses of pathogenesis are considered. The period of discovery of the relationship between increased blood pressure and the use of foods containing tyramine is outlined. The transformation of terminology is demonstrated. The events associated with the restriction of the use of therapy are characterized. The formation of the opinion about the exaggeration of the risk of d

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Li, Yuwei, Tingting Yan, Lijun Yin, Yongqiang Cheng, and Xin Jia. "Isolation and identification of tyramine-producing bacteria and their biogenic amines formation during fermentation of sufu." Cellular and Molecular Biology 68, no. 1 (2022): 75–88. http://dx.doi.org/10.14715/cmb/2022.68.1.11.

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The Chinese traditional soybean product, sufu, is getting increasingly popular in Asia for its special taste and rich nutrition. In this paper, physicochemical properties of sufu during fermentation, isolation and characterization of BA-producing bacteria, as well as their decarboxylase activities were thoroughly investigated. Tyramine, putrescine, phenylethylamine and cadaverine were the main BA in sufu fermentation. Tyramine level increased drastically to reach 513.72 mg/kg during sufu ripening, posing potential health risks. During sufu fermentation, there was a positive correlation between

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26

Ehsani, Ali, Mohammad Ghasem Mahjani, Ferydon Babaei, and Hossein Mostaanzadeh. "Physioelectrochemical and DFT investigation of metal oxide/p-type conductive polymer nanoparticles as an efficient catalyst for the electrocatalytic oxidation of methanol." RSC Advances 5, no. 38 (2015): 30394–404. http://dx.doi.org/10.1039/c5ra02297e.

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Blob, Lawrence F., Melvin Sharoky, Bryan J. Campbell, et al. "Effects of a Tyramine-Enriched Meal on Blood Pressure Response in Healthy Male Volunteers Treated with Selegiline Transdermal System 6 mg/24 Hour." CNS Spectrums 12, no. 1 (2007): 25–34. http://dx.doi.org/10.1017/s1092852900020496.

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ABSTRACTBackground:Monoamine oxidase inhibitors are well recognized as effective antidepressant agents but are rarely used due, in part, to the risk of hypertensive crisis following the ingestion of foods high in tyramine (“cheese reaction”). A selegiline transdermal system (STS) was developed to provide antidepressant concentrations of selegiline in the brain, while preserving the gastrointestinal monoamine oxidase A (MAO-A) barrier. The present study was conducted to determine the effect of the STS 6 mg/24 hour on cardiovascular safety following the ingestion of ∼400 mg of tyramine consumed

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KRIZEK, ANGELIA R., J. SCOTT SMITH, and RANDALL K. PHEBUS. "Biogenic Amine Formation in Fresh Vacuum-Packaged Beef Stored at −2°C and 2°C for 100 Days." Journal of Food Protection 58, no. 3 (1995): 284–88. http://dx.doi.org/10.4315/0362-028x-58.3.284.

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When fresh, vacuum-packaged, meat products are stored for extended periods of time, undesirable changes, due to naturally occurring microbial flora present during packaging occur. Lactobacillus spp. are known to form amines through the decarboxylation of free amino acids. Tyramine and histamine can cause intoxication in individuals taking monoamine oxidase-inhibiting drugs. This study determined 1) the effect of storage temperature on bacterial growth and biogenic amine production in vacuum-packaged beef subprimals, 2) the effect of washing subprimals with water to remove tyramine contaminatio

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Atasoy, Gülsüm, Pınar Şanlıbaba, and Rahmi Ertan Anlı. "Isolation and Identification of Tyramine-Producing Lactic Acid Bacteria from Fermented Olives." Turkish Journal of Agriculture - Food Science and Technology 10, no. 10 (2022): 1871–76. http://dx.doi.org/10.24925/turjaf.v10i10.1871-1876.5345.

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In the present study, we aimed to isolate and biochemically identify tyramine-producing lactic acid bacteria (LAB) from black and green fermented olive samples produced by traditional methods and obtained from different provinces of Turkey. A total of 36 LABs, including Enterococcus spp. (2 isolates), Lactobacillus spp. (16 isolates), and Lactococcus spp. (18 isolates) were isolated from the fermented olive samples. Among them, 27 isolates could decarboxylate tyrosine amino acid; however, the decarboxylase enzyme activity of the remaining 9 isolates was negative. The ability of LAB isolates wi

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Johns, Paul W., and Steven R. Hertzler. "Substantial Depletion of Vicine, Levodopa, and Tyramine in a Fava Bean Protein-Based Nutritional Product." International Journal of Food Science 2021 (January 29, 2021): 1–10. http://dx.doi.org/10.1155/2021/6669544.

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A commercial fava bean protein isolate and a liquid nutritional product formulated with it were tested by validated HPLC methods for the favism-associated pyrimidine glycoside vicine, the dopamine precursor levodopa, and the biogenic amine tyramine. The vicine, levodopa, and tyramine concentrations in the protein isolate—306, 13.3, and <0.5 mg/kg, respectively—when expressed on a protein basis—34, 1.5, and <0.06 mg/100 g protein, respectively—were at least 96% lower than the vicine, levodopa, and tyramine (protein-based) concentrations reported for fava beans (≥900, ~200, and ~4 mg/100 g

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Fernández, María, Daniel M. Linares, Beatriz del Río, Victor Ladero, and Miguel A. Alvarez. "HPLC quantification of biogenic amines in cheeses: correlation with PCR-detection of tyramine-producing microorganisms." Journal of Dairy Research 74, no. 3 (2007): 276–82. http://dx.doi.org/10.1017/s0022029907002488.

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The consumption of food and beverages containing high amounts of biogenic amines (BA) can have toxicological effects. BA found in foods and beverages are synthesized by the microbial decarboxylation of certain amino acids. This paper reports the concentrations of BAs in a number of commercial cheeses, as determined by HPLC. The cheeses studied were made from raw and pasteurized milk of different origin, and were subjected to different ripening periods. BA concentrations were lower in short ripening period than in long ripening period cheeses, and higher in cheeses made from raw milk than in th

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Sapner, Vijay S., Balaji B. Mulik, Renuka V. Digraskar, Shankar S. Narwade, and Bhaskar R. Sathe. "Enhanced oxygen evolution reaction on amine functionalized graphene oxide in alkaline medium." RSC Advances 9, no. 12 (2019): 6444–51. http://dx.doi.org/10.1039/c8ra10286d.

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Metal free tyramine functionalized graphene oxide (T-GO) is a promising electrocatalyst for oxygen evolution reaction (OER) in alkaline medium having high activity and stability, resulting from the tyramine active sites.

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KIM, HYEONG SANG, and SUN JIN HUR. "Effect of In Vitro Human Digestion on Biogenic Amine (Tyramine) Formation in Various Fermented Sausages." Journal of Food Protection 81, no. 3 (2018): 365–68. http://dx.doi.org/10.4315/0362-028x.jfp-17-372.

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ABSTRACT Biogenic amines are formed in various fermented foods by microbial amino acid decarboxylation activities, and ingestion of these amines may cause human illness. However, the effect of digestion on the biogenic amines in fermented sausages has not been studied. This study was conducted to determine the effect of in vitro human digestion with the enterobacteria Escherichia coli and Lactobacillus casei on concentrations of the biogenic amine tyramine in six types of fermented sausages. Tyramine concentration was not significantly changed until simulated digestion in the small intestine.

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ANASTASIO, ANIELLO, ROSA DRAISCI, TIZIANA PEPE, et al. "Development of Biogenic Amines during the Ripening of Italian Dry Sausages." Journal of Food Protection 73, no. 1 (2010): 114–18. http://dx.doi.org/10.4315/0362-028x-73.1.114.

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The effect of modification of different chemical and microbiological parameters and the production of biogenic amines (histamine, cadaverine, putrescine, and tyramine) was examined during ripening of various types of typical Italian dry sausages (salami). Water activity decreased from 0.97 to 0.87, and pH reached the lowest value between the 13th and the 20th day of the ripening period, and then increased. Putrescine (up to 122.7 mg/kg) and tyramine (up to 105.9 mg/kg) mean levels showed dominance in comparison with cadaverine (up to 26.1 mg/kg) and histamine (up to 6.2 mg/kg) mean values in a

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Almeida, Cláudio M. R., Maria Fátima Barroso, Manuela M. Moreira, Júlia M. C. S. Magalhães, and Luisa Durães. "Direct Electrochemical Detection of Tyramine in Beer Samples Using a MWCNTs Modified GCE." Sensors 25, no. 11 (2025): 3322. https://doi.org/10.3390/s25113322.

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In this study, an electrochemical method is presented for the direct determination of tyramine in beer samples. A multi-walled carbon nanotubes (MWCNTs) modified glassy carbon electrode (GCE) was developed for the detection and quantification of tyramine at a low potential of 0.53 V. The electrochemical process and sensor parameters were thoroughly investigated to establish optimal analysis conditions. The method demonstrated a linear response range from 3 to 9 µM, with a limit of detection (LOD) of 0.34 µM and a limit of quantification (LOQ) of 1 µM. The developed sensor was successfully appl

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Aldosary, F., P. Tremblay, C. Hébert, and P. Blier. "Atomoxetine, but not paroxetine, blocks norepinephrine reuptake in depressed patientss." Clinical & Investigative Medicine 30, no. 4 (2007): 72. http://dx.doi.org/10.25011/cim.v30i4.2838.

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Purpose: Paroxetine is a potent serotonin (5-HT) reuptake inhibitor. However, a purported norepinephrine (NE) reuptake blockade action remains to be established. Atomoxetine is a potent NE reuptake inhibitor with the indication of attention deficit hyperactivity disorder (ADHD). The present study was aimed at confirming a NE reuptake inhibitory action with ascending doses of atomoxetine and possibly with paroxetine in depressed patients.  Methods: Patients were randomized to escalating doses of either paroxetine (20 to 50 mg/day), or atomoxetine (25-80 mg/day) in a four to six week perio

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Thamm, Markus, Katharina Wagler, Axel Brockmann, and Ricarda Scheiner. "Tyramine 1 Receptor Distribution in the Brain of Corbiculate Bees Points to a Conserved Function." Brain, Behavior and Evolution 96, no. 1 (2021): 13–25. http://dx.doi.org/10.1159/000517014.

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Sucrose represents an important carbohydrate source for most bee species. In the Western honeybee (<i>Apis mellifera</i>) it was shown that individual sucrose responsiveness correlates with the task performed in the colony, supporting the response threshold theory which states that individuals with the lowest threshold for a task-associated stimuli will perform the associated task. Tyramine was shown to modulate sucrose responsiveness, most likely via the tyramine 1 receptor. This receptor is located in brain areas important for the processing of gustatory stimuli. We asked whether

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Coton, Monika, María Fernández, Hein Trip, et al. "Characterization of the tyramine-producing pathway in Sporolactobacillus sp. P3J." Microbiology 157, no. 6 (2011): 1841–49. http://dx.doi.org/10.1099/mic.0.046367-0.

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A sporulated lactic acid bacterium (LAB) isolated from cider must was shown to harbour the tdc gene encoding tyrosine decarboxylase. The isolate belonged to the Sporolactobacillus genus and may correspond to a novel species. The ability of the tdc-positive strain, Sporolactobacillus sp. strain P3J, to produce tyramine in vitro was demonstrated by using HPLC. A 7535 bp nucleotide sequence harbouring the putative tdc gene was determined. Analysis of the obtained sequence showed that four tyramine production-associated genes [tyrosyl-tRNA synthetase (tyrS), tyrosine decarboxylase (tdc), tyrosine

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Domínguez, Mario, Sofía Oliver, Rosa Garriga, et al. "Tectomer-Mediated Optical Nanosensors for Tyramine Determination." Sensors 23, no. 5 (2023): 2524. http://dx.doi.org/10.3390/s23052524.

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The development of optical sensors for in situ testing has become of great interest in the rapid diagnostics industry. We report here the development of simple, low-cost optical nanosensors for the semi-quantitative detection or naked-eye detection of tyramine (a biogenic amine whose production is commonly associated with food spoilage) when coupled to Au(III)/tectomer films deposited on polylactic acid (PLA) supports. Tectomers are two-dimensional oligoglycine self-assemblies, whose terminal amino groups enable both the immobilization of Au(III) and its adhesion to PLA. Upon exposure to tyram

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Ladero, Victor, María Fernández, and Miguel A. Alvarez. "Isolation and identification of tyramine-producing enterococci from human fecal samples." Canadian Journal of Microbiology 55, no. 2 (2009): 215–18. http://dx.doi.org/10.1139/w08-133.

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Lactic acid bacteria (LAB) are recognized as a group of important microorganisms because of their crucial role in food fermentation and their contribution to the maintenance of health homeostasis, as natural inhabitants of the human mucosa. However, the metabolic activities of some strains, such as the ability to synthesize biogenic amines (BAs), can be detrimental to human health. BAs are low molecular weight compounds synthesized by the enzymatic decarboxylation of amino acids. Tyramine, one of the most biologically active BAs, is produced by certain strains of LAB related to food fermentati

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Chakkarapani, Lakshmi Devi, and Martin Brandl. "Carbon Screen-Printed Electrode Coated with Poly (Toluidine blue) as an Electrochemical Sensor for the Detection of Tyramine." Engineering Proceedings 2, no. 1 (2020): 51. http://dx.doi.org/10.3390/ecsa-7-08171.

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In the present work the surface modification of a carbon screen-printed electrode by electrochemical polymerization of toluidine blue (TB) for determination of tyramine is described. The electrochemical polymerization of the electrode with TB was done by cyclic voltammetry at a scan rate of 50 mV/s and a potential sweep between ‒0.7 V and 1.0 V in the presence of 0.5 mM TB in an electrolyte solution. At each cycle, the polymer film started to deposit on the carbon screen-printed electrode which was repeated 20 times. For parameter optimization the electrochemical behavior of the modified elect

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Sun, Xueying, Erke Sun, Lina Sun, et al. "Effect of Biogenic Amine-Degrading Lactobacillus on the Biogenic Amines and Quality in Fermented Lamb Jerky." Foods 11, no. 14 (2022): 2057. http://dx.doi.org/10.3390/foods11142057.

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This study compares five types of lamb jerky, namely, CO (without starter culture), PL-4 (with producing putrescine, cadaverine, histamine, and tyramine), BL4-8 (degrading putrescine, cadaverine, histamine, and tyramine), CL4-3 (degrading putrescine and tyramine), and X3-2B (degrading histamine and tyramine). A study was performed to examine the effects of starter culture on the physical–chemical quality, flavor, and biogenic amines (BAs) during fermentation and ripening. At the end of fermentation, the pH value of the BL4-8 group (4.75) was significantly lower than that of other groups (p &lt

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Iepsen, U. W., G. W. Munch, C. K. Ryrsø та ін. "Muscle α-adrenergic responsiveness during exercise and ATP-induced vasodilation in chronic obstructive pulmonary disease patients". American Journal of Physiology-Heart and Circulatory Physiology 314, № 2 (2018): H180—H187. http://dx.doi.org/10.1152/ajpheart.00398.2017.

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Sympathetic vasoconstriction is blunted in exercising muscle (functional sympatholysis) but becomes attenuated with age. We tested the hypothesis that functional sympatholysis is further impaired in chronic obstructive pulmonary disease (COPD) patients. We determined leg blood flow and calculated leg vascular conductance (LVC) during 1) femoral-arterial Tyramine infusion (evokes endogenous norepinephrine release, 1 µmol·min−1·kg leg mass−1), 2) one-legged knee extensor exercise with and without Tyramine infusion [10 W and 20% of maximal workload (WLmax)], 3) ATP (0.05 µmol·min−1·kg leg mass−1)

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LIU, FANG, LIHUI DU, HAIHONG WU, et al. "Effects of Storage Temperature on Tyramine Production by Enterococcus faecalis R612Z1 in Water-Boiled Salted Ducks." Journal of Food Protection 77, no. 10 (2014): 1804–8. http://dx.doi.org/10.4315/0362-028x.jfp-14-141.

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Tyramine production by Enterococcus faecalis R612Z1 in water-boiled salted ducks was evaluated during storage at different temperatures. The results showed that E. faecalis R612Z1 could produce tyramine in meat samples when the storage temperature was no less than 4°C. The E. faecalis R612Z1 counts of the meat samples reached 108 CFU/g on day 7 at 4°C and on day 4 at 10°C. However, the tyramine content of the meat samples stored at 10°C increased to 23.73 μg/g (on day 10), which was greater than the level in the samples stored at 4°C (7.56 μg/g). Reverse transcription quantitative PCR detectio

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Danser, A. H., R. van den Ende, R. R. Lorenz, N. A. Flavahan, and P. M. Vanhoutte. "Prejunctional beta 1-adrenoceptors inhibit cholinergic transmission in canine bronchi." Journal of Applied Physiology 62, no. 2 (1987): 785–90. http://dx.doi.org/10.1152/jappl.1987.62.2.785.

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The aim of the present study was to determine in canine bronchi the effects produced by norepinephrine (released from adrenergic nerve terminals) on cholinergic neurotransmission. Electrical stimulation of canine bronchi activates cholinergic and adrenergic nerve fibers. The adrenergic neuronal blocker, bretylium tosylate, inhibited the increase in [3H]norepinephrine overflow evoked by electrical stimulation but did not prevent that caused by the indirect sympathomimetic tyramine. During blockade of the exocytotic release of norepinephrine with bretylium, the pharmacological displacement of th

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Berlin, Ivan, and Patricia Molinier. "Oral tyramine challenge tests." Clinical Pharmacology and Therapeutics 54, no. 2 (1993): 230–31. http://dx.doi.org/10.1038/clpt.1993.137.

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Studnitz, Wilfried, and Otto Ljungberg. "Tyramine Test and Phaeochromocytoma." Acta Medica Scandinavica 182, no. 3 (2009): 341–44. http://dx.doi.org/10.1111/j.0954-6820.1967.tb11533.x.

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Naylor, G. J., A. S. Hale, M. Sandler, P. Hannah, and P. K. Bridges. "TYRAMINE CONJUGATION AND ANTIDEPRESSANTS." Lancet 333, no. 8643 (1989): 904. http://dx.doi.org/10.1016/s0140-6736(89)92900-0.

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Tiller, J. W. G., K. P. Maguire, B. M. Davies, J. T. Dowling, L. H. Tung, and M. J. Rand. "Tyramine-Induced cardiac arrhythmias." Human Psychopharmacology: Clinical and Experimental 5, no. 4 (1990): 313–21. http://dx.doi.org/10.1002/hup.470050404.

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Bhardwaj, Arun, Hittu Gupta, Ramya Iyer, Naresh Kumar, and Ravinder Kumar Malik. "Tyramine-producing enterococci are equally detected on tyramine production medium, by quantification of tyramine by HPLC, or bytdcgene-targeted PCR." Dairy Science and Technology 89, no. 6 (2009): 601–11. http://dx.doi.org/10.1051/dst/2009040.

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