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1

Weinel, Allison Clare. "Comparative aspects of tyrosinase activity : purification of human tyrosinase from IGR1 cells and comparison of properties with tyrosinase from Agaricus bisporus." Thesis, Brunel University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282921.

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2

Hossain, Abzal. "Inhibition of tyrosinase activity by metallothionein from Aspergillus niger." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/MQ55068.pdf.

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3

Nkabinde, Nkosana Cyril. "Synthesis and activity of tyrosinase in mouse skin melanocytes." Master's thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/27178.

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Tyrosinase (E.C. 1.14.18.1) is a key enzyme in the biosynthesis of melanin. The control of melanin sythesis was explored in skin melanocytes of the following strains; wild type (C57BL/6J-C/C) (which maximally synthesize melanin at normal mammalian body temperature, Himalayan (C57BL/6J-cʰ/cʰ) (which maximally synthesize melanin at temperatures below 37°C) and albino (Balb c-c/c) (a mutant which does not synthesize melanin) The effect of a-MSH on tyrosinase activity was initially investigated. A skin culture tyrosinase assay that made it possible to measure the effect of α-MSH on the activity of
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4

Narli, Isil. "Activity Analysis Of Immobilized Tyrosinase In The Presence Of Different Inhibitors." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607238/index.pdf.

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ACTIVITY ANALYSIS OF IMMOBILIZED TYROSINASE ENZYME IN THE PRESENCE OF DIFFERENT INHIBITORS Narli, ISil M.Sc., Department of Chemistry Supervisor: Prof. Dr. Levent Toppare May 2006, 97 pages Immobilization of tyrosinase enzyme was performed in the matrices obtained via copolymerization of terephthalic acid bis-(2-thiophen-3-yl ethyl) ester (TATE) with pyrrole. During electrochemical polymerization of pyrrole, enzyme molecules were entrapped in the copolymer matrice. Activity measurements were performed by using Besthorn&amp<br>#8217<br>s Hydrazone method which includes spectrophotometri
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5

Seechurn, L. M. P. I. "The regulation of tyrosinase activity in epidermal melanocytes in the mouse." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384020.

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6

Juneja, Kashmir Singh. "Tyrosinase-like activity of several Alzheimer's disease related and model peptides and their inhibition by natural antioxidants." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001838.

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7

Msebele, Bongiwe. "Application of Sutherlandia flutescens in cosmetic skin industry (phytochemical fingerprinting and its activity against skin immune diseases." University of the Western Cape, 2019. http://hdl.handle.net/11394/7368.

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>Magister Scientiae - MSc<br>Hyperpigmentation disorders such as melasma, freckles and black-pigmented spots on the surface of the skin are often a result of increased over production and accumulation of melanin pigments in the skin. In melanin biogenesis, tyrosinase is the key enzyme that catalysis the synthesis of melanin, thus the most effective and easiest way to reduce melanin synthesis is by inhibiting tyrosinase. There are a large number of reported tyrosinase inhibitors, their identification and isolation from natural sources is highly important because when natural tyrosinase in
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8

de, la Torre Jerry James Murillo. "Effect Of Frequency On Polyphenoloxidase Activity During Moderate Electric Field Treatment." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1231859740.

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9

Schmitt, Marie. "CHAVIC - Valorisation de la flore Champardennaise dans le domaine du vieillissement cutané." Thesis, Reims, 2019. http://www.theses.fr/2019REIMS030.

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Ce travail présente l'étude phytochimique et l’évaluation biologique de neuf plantes récoltées en région Champagne-Ardenne afin de les valoriser dans le traitement du vieillissement cutané. Il s'agit des espèces Agrimonia eupatoria, Geum urbanum (Rosaceae), Colutea arborescens, Hippocrepis emerus, Lotus maritimus (Fabaceae), Equisetum arvense (Equisetaceae), Linaria vulgaris (Scrophulariaceae), Melampyrum sylvaticum (Orobanchaceae) et Prunella vulgaris (Lamiaceae). Les extraits bruts (MeOH, CH2Cl2, AcOEt, n-BuOH) de ces neuf plantes ont été criblés grâce à des tests d'activités antioxydantes (
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10

Verdoni, Marion. "Identification, caractérisations physico-chimiques et pharmacologiques de nouveaux inhibiteurs de la mélanogenèse isolés à partir de venins d'animaux : exemple de l'Argiotoxine-636." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4720.

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La mélanogenèse engage 3 enzymes. La tyrosinase catalyse l’oxydation des 2 premiers substrats pour former la DOPAquinone. Celle-ci, en présence de cystéine peut s’y conjuguer pour produire des pheomélanines (pigments clairs). En son absence, la DOPAquinone est convertie en DOPAchrome, précurseur de la voie de synthèse des eumélanines (pigments foncés). Leur formation implique deux autres enzymes : TRP-1 et TRP-2. Un dérèglement de ce processus entraîne des dermatoses de type hyperpigmentations chez les phototypes IV à VI. Traiter ces problématiques efficacement sans effets secondaires nécessit
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11

Miranda, Andre José Cardoso de. "Estudo da cinética da tirosinase imobilizada em nanopartícula de sílica com obtenção de revestimento de eumelanina." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-05042016-111550/.

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Melanina é um polímero constituído por uma grande heterogeneidade de monômeros tendo como característica comum a presença de grupos indóis. Por outro lado, a eumelanina produzida pela oxidação enzimática da tirosina é um polímero mais simples constituído principalmente de monômeros 5,6-dihidroxindol (DHI) e de indol-5,6-quinona (IQ). Tirosinase é a enzima chave na produção de melanina, sendo que a sua atividade cinética é medida em função da formação do intermediário dopacroma. Nanopartículas (NPs) de sílica são partículas nanométricas compostas de oxido de silício e são obtidas pelo processo
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12

Reynolds, Andrew Robert. "Functional fluorescence imaging of receptor tyrosine kinase activity in cells." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398898.

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13

Seaton, Angela. "Anti-tumour activity of novel phenolic compounds." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324524.

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14

Duplaquet, Leslie. "Implication du récepteur à activité tyrosine kinase (RTK) MET sur la balance survie/apoptose et identification de nouvelles mutations de RTKs dans les cancers colorectaux métastatiques." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S031/document.

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Les RTKs sont impliqués dans le dialogue au sein des tissus par la régulation de nombreuses réponses cellulaires dont la survie, la prolifération ou la mobilité. Dans les cancers, ces récepteurs sont fréquemment dérégulés notamment par des mutations activatrices. Ainsi, la suractivation des RTKs induit la transformation cellulaire et la tumorigenèse en favorisant par exemple la survie cellulaire. Depuis le début des années 2000, le développement de molécules inhibitrices de l’activité tyrosine kinase (TKI) et d’anticorps bloquant l’interaction ligand/récepteur ont montré que les RTKs représent
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15

Dubuque, Suzanne Hope. "Tyrosine kinase activity in the developing olfactory system of Manduca sexta." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282786.

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To begin to determine the role tyrosine kinases play in the development of the antennal lobe in Manduca sexta, phosphotyrosine levels were examined immunocytochemically during critical periods of development. Tyrosine phosphorylation was found to be highest in the region of the antennal lobe known to contain the growing tips of antennal-lobe neurons and forming synapses. To explore the relationship between synapses and tyrosine kinase activity a marker for synapses was developed for light level microscopy. Manduca synaptotagmin was cloned and sequenced and a polyclonal antibody (SYNT76) was p
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16

Saharinen, Pipsa. "Signaling through the Jak-Stat pathway : regulation of tyrosine kinase activity." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/saharinen/.

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17

Lynch, Deborah Frances. "The role of tyrosine, serine and threonine phosphorylation in the regulation of the insulin receptor tyrosine kinase activity." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282141.

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18

Pursglove, Sharon Elizabeth. "Biophysical analysis of Tec Kinase regulatory regions : implications for the control of Kinase activity." Title page, contents and summary only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09php9863.pdf.

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19

Kaulagari, Sridhar Reddy. "Design, Synthesis & Biological Activity of Novel Protein Tyrosine Phosphatase (PTP) Mimetics." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3462.

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Protein phosphorylation is a post translational modification of proteins in which a serine, a threonine or a tyrosine residue is phosphorylated by an enzyme, kinase. Phosphorylation of proteins is a reversible and very important regulatory mechanism that occurs in both prokaryotes and eukaryotes. Phosphorylation turns many protein enzymes on and off, preventing or causing many diseases such as diabetes, cancer and rheumatoid arthritis. The phosphorylation on tyrosine residues of proteins is essential for transmission of signals for cell growth, proliferation and differentiation. Protein tyrosi
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20

Lermet, Anne. "Synthèse d'inhibiteurs de la protéine à activité tyrosine kinase c-kit de type sauvage et muté." Lyon 1, 2006. http://www.theses.fr/2006LYO10026.

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21

Barras, Alexandre. "Synthèse et vectorisation d'inhibiteurs du récepteur à activité tyrosine kinase MET." Lille 2, 2009. http://www.theses.fr/2009LIL2S021.

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Les protéines kinase jouent un rôle central dans la régulation de nombreux processus cellulaires. Parmi elles, le récepteur MET est un récepteur transmembranaire à activité tyrosine kinase (RTK) présent sur les cellules épithéliales. Son ligand est le facteur de croissance HGF/SF (Hepatocyte Growth Factor/Scatter factor). L'activation de MET par HGF/SF stimule la survie et la prolifération de nombreux types cellulaires et de manière caractéristique la dispersion, l'invasion et la morphogenèse de cellules épithéliales. Dans de nombreux cancers (carcinomes, sarcomes. . . ), l'HGF/SF et MET sont
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22

Nxumalo, Fikile. "Influence of vanadium(V) complexes on the catalytic activity of protein tyrosine phosphates." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24218.pdf.

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23

Beslu, Nathalie. "Etude des interactions et de ses conséquences fonctionnelles, des substrats (PI3K, GRB2) du récepteur hématopoîétique à activité tyrosine kinase : flt3." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX22052.

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Le recepteur flt3 est un recepteur hematopoietique a activite tyrosine kinase de classe iii. L'interaction de ce type de recepteur avec leur ligand induit leur homodimerisation, et conduit a leur transphosphorylation sur les residus tyrosine. Ces residus une fois phosphoryles interagissent specifiquement avec les domaines sh2 de proteines cytoplasmiques, conduisant a la transduction du signal. Nous avons dans un premier temps, entrepris de muter ces residus tyrosine pour identifier les sites d'interaction de certains substrats avec flt3. Cela nous a permis de montrer que la sous-unite p#8#5 de
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24

Selner, Nicholas. "PROFILING THE INTRINSIC SEQUENCE SPECIFICITY OF PROTEIN TYROSINE PHOSPHATASES." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1384269733.

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25

Grangeasse, Christophe. "Phosphorylation des protéines bactériennes au niveau de la tyrosine : étude des activités protéine-tyrosine kinase et phosphotyrosine-protéine phosphatase chez Acinetobacter johnsonii." Lyon 1, 1998. http://www.theses.fr/1998LYO10061.

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Nous avons demontre l'existence d'une modification post-traductionnelle des proteines par phosphorylation chez la bacterie acinetobacter johnsonii. Cette modification concerne principalement une proteine de 82 kilodaltons, localisee dans la membrane interne de la cellule bacterienne, que nous avons purifiee a homogeneite. Nous avons montre que cette proteine, appelee ptk pour prokaryotic protein-tyrosine kinase, est capable de s'autophosphoryler au niveau de plusieurs residus de tyrosine. Le gene correspondant, ptk, a ete clone et totalement sequence. L'analyse theorique de la sequence de la p
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26

Zhang, Yu Ling. "Characterization of HD-PTP phosphatase activity and identification of its substratesbinding partners." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111552.

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Histidine-Domain-Protein-Tyrosine-Phosphatase (HD-PTP) has been classified as a non-transmembrane protein tyrosine phosphatase (PTP), however, its catalytic activity has not been appropriately characterized. In this thesis, the tyrosine phosphatase activity of HD-PTP was characterized. To do so, the HD-PTP protein was successfully purified using the FLAG-TAG purification system and an enzymatic assay was carried out using the DiFMUP fluorogenic substrate. My results suggest that HD-PTP is an inactive PTP that can be reactivated upon the back mutation of a conserved amino acid located in its ca
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27

Grassot, Julien. "Évolution des récepteurs à activité tyrosine kinase : un modèle pour mieux comprendre l'évolution des métazoaires." Lyon 1, 2004. http://www.theses.fr/2004LYO10160.

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Les récepteurs à activité tyrosine kinase (RTK) sont des récepteurs exprimés à la surface des cellules, retrouvés exclusivement chez les métazoaires, de l'éponge à l'homme. Ils participent au contrôle et à la régulation de nombreux processus cellulaires fondamentaux tels que le cycle cellulaire, la migration, le métabolisme, autant que survie, prolifération et différenciation. Des mutants de RTK sont impliqués dans des maladies génétiques ou dans des phénomènes d'oncogenèse. Bien que les RTK soient étudiés activement en raison de leur grande importance fonctionnelle, il n'existait aucune sourc
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28

Lloyd-George, Ian. "The conversion of ammonia, phenol and pyruvate into tyrosine by the use of the tyrosine phenol-lyase activity of microencapsulated Erwinia Herbicola." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41200.

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The tyrosine phenol-lyase (TPL)-E.C. 4.1.99.2-activity of free and alginate-polylysine-alginate microencapsulated whole cells of Erwinia herbicola, was used to convert ammonia, pyruvate and phenol or catechol into L-tyrosine of dihydroxyphenyl-L-alanine (L-dopa). This conversion could serve as the basis of a novel system for the removal of toxic ammonia and phenol from the blood during liver failure.<br>It was found that there were endogenous modifiers in the whole cell TPL system, hence the kinetic parameters vary with the amount of cells in the system. However typically the apparent $ rm K s
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29

White, Kylie Suzanne, та kyes_w@yahoo com. "The antimicrobial mechanism of action of 3,4-methylenedioxy-β-nitropropene". RMIT University. Applied Sciences, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20090723.101430.

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This research investigated the mechanism of action in bacteria of 3,4-methylenedioxy-β-nitropropene (BDM-I), a very broad spectrum antimicrobial lead compound in development as an anti-infective drug. The thesis proposes that BDM-I inhibits bacterial protein tyrosine phosphatases, a novel mechanism of action for an antimicrobial agent and a new target in microorganisms. This very open investigation was directed by considerable biological information on the effects of BDM-I in microorganisms and animals which provided insights into possible and improbable cellular targets. The biological ef
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30

Borg, Jean-Paul. "Caractérisation biochimique et fonctionnelle de FLT4 : un récepteur à activité tyrosine kinase." Aix-Marseille 2, 1995. http://www.theses.fr/1995AIX22035.

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Les recepteurs flt4, flt1/vegfr1 et flk1/vegfr2 constituent un groupe de proteines preferentiellement exprimees sur les cellules endotheliales et leurs progeniteurs. Ces proteines de type i sont constituees d'une region extracytoplasmique formee de 7 boucles ig, d'une region transmembranaire et d'une partie cytoplasmique contenant un domaine tyrosine kinase interrompu par une region hydrophilique. Le recepteur humain flt4 a ete clone dans notre laboratoire en 1992 et est present dans les tissus normaux (placenta, rate, poumon et cur) ainsi que dans plusieurs lignees cellulaires. Le vegf/vpf, u
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31

André, Catherine. "Les oncogenes c-kit et c-fms : recepteurs a activite tyrosine kinase." Paris 7, 1992. http://www.theses.fr/1992PA077214.

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Les produits des oncogenes c-fms et c-kit, les pdgfra et pdgfrb appartiennent a la sous-classe iii des recepteurs a activite tyrosine kinase (rtk). Leurs genes sont localises par paire chez l'homme et la souris. Nous avons clone et sequence l'oncogene c-kit humain, sa structure genomique est homologue a celle de c-fms; les deux genes: 60 kb pour c-fms, 80 kb pour c-kit, leur structure exons/introns est identique dans le domaine catalytique. L'organisation genomique de c-kit et c-fms, la localisation chromosomique particuliere des genes de la sous-classe iii des rtk, ainsi que leurs fonctions c
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32

Epstein, Richard John. "Positive and negative regulation of receptor tyrosine kinase activity in normal and malignant cells." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294914.

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33

El-Zarruk, Assia Ali. "Epidermal growth factor and associated tyrosine kinase activity in human breast cancer cell lines." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361245.

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34

Buccellato, Matthew Allan. "Host-mediated Alteration of Measles Virus Polymerase Activity: Consequences for the Outcome of Infection." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1210961676.

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35

Santoro, Massimo M. "The binding of 14-3-3 proteins to the Ron receptor is required for its biological activity." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342901.

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36

Polychronidou, Maria. "Studying the role of dimerization in regulating the activity of Receptor Protein Tyrosine Phosphatase Sigma." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99198.

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RPTP-sigma is a member of the LAR-RPTP subfamily that has been associated with neurite outgrowth and neuronal regeneration. In this study, it is reported that dimenzation, seems to play a role in the regulation of RPTP-sigma activity. RPTP-sigma forms homodimers in cells under physiological conditions and antibody induced dimerization of HA-tagged RPTP-sigma leads to changes in the localization of the protein from the plasma membrane to vesicles in the cytoplasm. Furthermore, when N1E-115 cells were used as an in vitro model for studying the effect of RPTP-sigma-dimerization on neurite outgrow
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37

Abe, Mineo. "Development of peptide inhibitors of the receptor tyrosine kinase activity in a novel inhibitory mechanism." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120515.

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38

Elghazi, Lynda. "Développement du pancréas : rôle de ligands spécifiques de récepteurs à activité tyrosine kinase." Paris 7, 2002. http://www.theses.fr/2002PA077074.

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39

FOURNIER, EMMANUEL. "Etude fonctionnelle de deux isoformes d'un recepteur a activite tyrosine kinase : flt4/vegfr3." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX22088.

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Flt4/vegfr3 est un recepteur a activite tyrosine kinase (rtk) apparente a la famille des recepteurs au vegf. Ce recepteur, d'abord present sur des precurseurs endotheliaux, a une expression restreinte a l'endothelium lymphatique chez l'adulte. Le gene vegfr3 humain code pour deux isoformes du recepteur appelees : vegfr3 long et vegfr3 court. Ces deux proteines different seulement dans leurs portions intracytoplasmiques. Vegfr3 long a 65 acides amines (aa) supplementaires en position carboxy-terminale par rapport a vegfr3 court. Dans un test de croissance sur milieu semi-solide, seules des cell
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40

Yu, Ming-Wen, and 余明雯. "Analysis of Antioxidant Activity and Inhibitory Activity of Tyrosinase in Calamondin Peel." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/27353200082881285122.

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碩士<br>國立宜蘭大學<br>食品科學系碩士班<br>99<br>The present study was to evaluate the antioxidant activity, tyrosinase inhibitory activity and the related active compounds of peel in Calamondin. The peels were extracted by 90℃ hot water and ethyl acetate, respectively, to obtain the optimal extraction condition according to the antioxidant activity and tyrosinase inhibitory activity. Then, the extracts were separated by semi-preparative C18 column and collected. Furthermore, the identification of its active component related to the inhibition of tyrosinase activity were also carried out. The results sh
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41

Li, Xiao-Han, and 黎筱涵. "Study on inhibitory tyrosinase activity of Pleurotus ostreatus during storage and purification of the inhibitory tyrosinase components." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/48650873333196264231.

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碩士<br>國立宜蘭大學<br>食品科學系碩士班<br>98<br>Tyrosinase is the key enzyme of the melanin synthesis pathway. When the melanin secretes excessively, it will cause enzymatic browning of food, and influence the appearance; made the spot in the skin, even to cause pigmentation, melanoma disease. Determine tyrosinase activity and inhibitory tyrosinase activity of the Pleurotus ostreatus water extract (PW) by stored at 4℃. PW didn’t have tyrosinase activity during 0~8 days of storage time. But it had tyrosinase inhibitory activity. The inhibition of Pleurotus ostreatus water extract stored 0 day (PW0) was 6.82%
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42

葉人愷. "SODTMP inhibits tyrosinase activity and enhances the anti-oxidant activity of skin in mice." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/54083141440461148927.

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碩士<br>國立彰化師範大學<br>生物技術研究所<br>95<br>In melanin biosynthesis, tyrosinase plays an important role in converting tyrosine into Dopa (dihydroxyphenylalanine) /dopaquinone and through a series of reactions, melanin could be synthesized and melanin may act as a superoxide anion scavenger in skin. In order to reduce melanin production and resupply anti-oxidant activity in skin at the same time, we designed a SODTMP which consists of zebrafish SOD1 gene and human TMP nucleotide sequence. The plasmid containing SODTMP gene was transformed into E. coli and the histidine tagged fusion protein was purified
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43

Lin, Jhih-Sheng, and 林志昇. "Effect of mycelial extracts on tyrosinase activity inhibition by Ganoderma lucidum." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/55836862550904973530.

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碩士<br>東海大學<br>化學工程與材料工程學系<br>98<br>Because tyrosinase is a key enzyme to the synthesis of melanin, tyrosinase inhibitors are considered to be effective to cosmetic skin-whitening. The purpose of this study is to investigate the effectiveness of tyrosinase inhibitors prepared from the mycelia of Ganoderma lucidum in submerged cultures and solid-state fermentations. Different extracts of mycelium and fermentation broths were compared for the inhibitory effect of tyrosinase activity. The experiment could be categorized mainly into four parts, which were the comparison of various fermented product
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44

Chien-Wen, Su, and 蘇倩雯. "Studies on the Tyrosinase Activity Enhancing Constituents of Lonicera japonica Thunb." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/56200839088125303928.

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碩士<br>靜宜大學<br>應用化學系<br>89<br>In our continuing search for natural source ingredient from Chinese medicinal herbs, was found that extracts of Lonicera japonica Thunb. showed the significant tyrosinase enhancing activity. In this study, the active constituent of Lonicera japonica Thunb. was isolated by the process of tyrosinase activity assay and column chromato-graphy. The structure was elucdiated by the spectroscopic methods and its activity was also achieved.
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Hsu, Wan-Chun, and 許婉君. "Evaluation of the antioxidative and anti tyrosinase activity of Lactuca indica." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/2n85n4.

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碩士<br>嘉南藥理科技大學<br>化妝品科技研究所<br>100<br>Lactuca indica (Compositae) is an edible wild vegetable, used as a folk medicine in anti-inflammatory,antibacterial, and other medications in Asia. We investigated the antioxidant and antityrosinase activities of methanol extract of L. indica. Total crude extract (methanolic extract) was further divided into ethyl acetate (EtOAc) and water fractions by a liquid-liquid partition procedure.In addition, the EtOAc subfraction and the water subfraction were further fractionated by silica gel 60 and Diaion HP 20 columns into twelve subfractions inclusive E1-E6 a
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Shen, Hung-chang, and 沈宏璋. "Study of 2,5- dihydroxyacetophenone on inhibition of tyrosinase activity and melanogenesis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06225043509635147186.

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碩士<br>國立臺南大學<br>生物科技學系碩士班<br>99<br>In this study, zebrafish and mice will be our animal model. Through the initial screening found a natural acetophenone compound, 2,5-dihydroxyacetophenone (2,5-DHAP) in zebrafish embryos to inhibit melanin biosynthesis results. In a progress reaserch, using B16 melanoma cell to analysis the mechanism of inhitibion of melanogenesis which is found that 2,5-DHAP has the abibility of depigment. 2,5-DHAP was identified as murine tyrosinase inhibitors. The inhibitory activity of 2,5-DHAP is stronger than the skin-whitening standard, arbutin, but slightly lower than
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Yeh, Szu-Chien, and 葉思見. "Studies on the Tyrosinase Activity Enhancing Constituents of Prunella vulgaris L." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/40564411898062901973.

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碩士<br>靜宜大學<br>應用化學系研究所<br>91<br>In our continuing search for natural source ingredient from Chinese medicinal herbs, was found that extracts of Prunella vulgaris L. showed the significant tyrosinase enhancing activity. In this study, the active constituent of Prunella vulgaris L. was isolated by the process of tyrosinase activity assay and column chromatography. The structure was elucdiate by the spectroscopic methods and its activity was also achieved.
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Wu, Chiu-Hui, and 吳秋慧. "Inhibition on Tyrosinase Activity and Melanoma Cell Growth by Bovine Colostrum Hydrolysates." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/34456730213949393249.

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碩士<br>大葉大學<br>生物產業科技學系<br>100<br>In recent years, there is an increasing interest in finding natural tyrosinase inhibitors from animals, plants and microorganisms. The tyrosinase inhibitors should have broad applications, especially, in food, medicinal and cosmetics products in relation to hyperpigmentation. This research used the bovine colostrums collected on the first to fifth days postpartum and normal milk to prepare skimmed colostrums and skimmed normal milk, and used two different enzymes, Alcalase and α-Chymotrypsin, to hydrolyze the samples, followed by investigating the inhibition of
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Chang, Wenlun, and 張文倫. "Effects of Cinnamomum cassia Presl Essential Oil on Tyrosinase Activity and Melanogenesis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/51033952539451947147.

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碩士<br>靜宜大學<br>化粧品科學系<br>100<br>Natural essential oils are extracted from different plant parts of aromatic crops, which have anti-bacterial and anti-infection effect. The characteristics of plant essential oil are fat-soluble and small molecules that can easily penetrate the skin and mucous membranes. Essential oils have been widely used for bactericidal, virucidal, fungicidal, insecticidal, medicinal and cosmetic applications. Recently many studies are focusing on the anti-melanogenesis and major active biomolecules in plant essential oils. However, no scientific study demonstrates that Cinna
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Ko, Arethusa, and 柯昭宇. "The Study on Antioxidative and Tyrosinase-Inhibiting Activity of New Resveratrol Analogues." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/08768157262265035512.

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碩士<br>國立嘉義大學<br>生物藥學研究所<br>95<br>Resveratrol (3,4’,5-trihydroxy-trans-stilbene), a natural phytoalexin present in grapes and other dietary plants, has been suggested as a potential cancer chemopreventive and chemotherapetic agent. This triphenolic stilbene possesses strong antioxidative and anticancer activities. We synthesized a series of resveratrol derivatives with different number or position of hydroxyl group, or with C-4’-halogen-substituents, and examined their biological properties by two systems: (1) antioxidative activity assay, and (2) tyrosinase inhibition assay. In the extracellul
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