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Dissertations / Theses on the topic 'Tyrosinase inhibition activity'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Hossain, Abzal. "Inhibition of tyrosinase activity by metallothionein from Aspergillus niger." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/MQ55068.pdf.

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2

Narli, Isil. "Activity Analysis Of Immobilized Tyrosinase In The Presence Of Different Inhibitors." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607238/index.pdf.

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ACTIVITY ANALYSIS OF IMMOBILIZED TYROSINASE ENZYME IN THE PRESENCE OF DIFFERENT INHIBITORS Narli, ISil M.Sc., Department of Chemistry Supervisor: Prof. Dr. Levent Toppare May 2006, 97 pages Immobilization of tyrosinase enzyme was performed in the matrices obtained via copolymerization of terephthalic acid bis-(2-thiophen-3-yl ethyl) ester (TATE) with pyrrole. During electrochemical polymerization of pyrrole, enzyme molecules were entrapped in the copolymer matrice. Activity measurements were performed by using Besthorn&amp<br>#8217<br>s Hydrazone method which includes spectrophotometri

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3

Juneja, Kashmir Singh. "Tyrosinase-like activity of several Alzheimer's disease related and model peptides and their inhibition by natural antioxidants." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001838.

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4

Seaton, Angela. "Anti-tumour activity of novel phenolic compounds." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324524.

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5

White, Kylie Suzanne, та kyes_w@yahoo com. "The antimicrobial mechanism of action of 3,4-methylenedioxy-β-nitropropene". RMIT University. Applied Sciences, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20090723.101430.

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This research investigated the mechanism of action in bacteria of 3,4-methylenedioxy-β-nitropropene (BDM-I), a very broad spectrum antimicrobial lead compound in development as an anti-infective drug. The thesis proposes that BDM-I inhibits bacterial protein tyrosine phosphatases, a novel mechanism of action for an antimicrobial agent and a new target in microorganisms. This very open investigation was directed by considerable biological information on the effects of BDM-I in microorganisms and animals which provided insights into possible and improbable cellular targets. The biological ef

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6

Yunus, Madiha. "Investigating the Effect of Regorafenib on the Expression and Activity of the Angiogenesis-Modulating Receptor Tyrosine Kinases." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29860.

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The past two decades have been vital for developing cancer treatments. Even though traditional chemotherapy remains the primary choice for most oral treatment regimens, the cancer treatment paradigm is shifting towards more personalised, mechanism-based and selective therapeutic strategies. Tremendous advances have been made in understanding the aberrant signal transduction pathways in cancer, and a myriad of oncogenic drivers have been identified as promising candidates for molecule-targeted therapies. By using small low-molecular-weight compounds, specific alterations in oncogenic molecules

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7

Ren, Huan. "Biological activity of the 2-phenylaminopyrimidine class receptor tyrosine kinase inhibitor imatinib mesylate (STI571) in malignant glioma." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419008.

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8

Tran, Amanda P. "Modulation of Receptor Protein Tyrosine Phosphatase Sigma Enhances Protease Activity to Relieve Chondroitin Sulfate Proteoglycan Inhibition of Peripheral Axons and Oligodendrocytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1528450936899252.

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9

Dool, Carly Jade 1985. "Pharmacologic inhibition of insulin receptor tyrosine kinase activity has antineoplastic effects similar to alloxan-induced insulin deficiency with less acute metabolic toxicity." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111555.

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Recent population studies provide evidence that individuals with high circulating insulin levels have a poor prognosis and/or increased risk of cancer development; however, laboratory studies concerning the role of insulin in breast cancer biology are sparse. We compared the growth of 4T1 murine breast cancer allografts in control mice, alloxan-induced hypoinsulinemic mice, and mice treated with the insulin/insulin-like growth factor-1 receptor tyrosine kinase inhibitor BMS-536924. Both interventions significantly decreased tumor growth versus control and decreased pathway activation downstrea

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10

Nguyen, Van tai. "Physiopathologie des toxicités hématologiques et vasculaires des inhibiteurs de récepteurs à activité tyrosine kinase anti-angiogénique dans le traitement du cancer." Electronic Thesis or Diss., Paris 13, 2025. http://www.theses.fr/2025PA131002.

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Les inhibiteurs de tyrosine kinase anti-angiogéniques (ITK) sont devenus des médicaments majeurs pour le traitement de divers types de cancer, mais leur utilisation est associée à une incidence élevée de toxicités sévères, notamment des toxicités hématologiques, telles que l'anémie sévère. Des différences considérables ont été observées entre les différents ITKs.Dans cette thèse, nous avons réalisé une méta-analyse afin d'évaluer plus efficacement la prévalence des toxicités des différents ITK anti-angiogéniques chez les patients atteints de cancer, ainsi que dans des sous-populations spécifiq

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11

Silina, Linda. "Targeting TYRO3 : A Novel Strategy to Radiosensitise Bladder Cancer Cells Review of Preclinical Studies to Improve Radiotherapy Response in Muscle-Invasive Bladder Cancer: Lessons and Perspectives TYRO3 Targeting as a Radiosensitizing Strategy in Bladder Cancer TYRO3 as a Molecular Target for Growth Inhibition and Apoptosis Induction in Bladder Cancer." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL024.

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Le cancer de la vessie est un problème majeur de santé publique. Il est le quatrième cancer le plus fréquent chez l’homme en termes d’incidence. 25% des cancers diagnostiqués sont des tumeurs envahissant le muscle (TVIM) présentant un mauvais pronostic. La cystectomie est le traitement standard de référence pour les TVIM, même si elle présente des inconvénients importants. La radiothérapie, associée à une chimiothérapie et à une résection transurétrale de la tumeur, émerge comme traitement conservateur alternatif. La chimiothérapie n’épargne pas les tissus sains et présentent de nombreux effet

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12

Yokota, Asumi. "INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph[+] leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity." Kyoto University, 2009. http://hdl.handle.net/2433/126449.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第14902号<br>医博第3387号<br>新制||医||977(附属図書館)<br>27340<br>UT51-2009-M816<br>京都大学大学院医学研究科医学専攻<br>(主査)教授武藤誠, 教授武田俊一, 教授松岡雅雄, 教授戸井雅和<br>学位規則第4条第1項該当

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13

Peyressatre, Marion. "Développement de biosenseurs fluorescents et d’inhibiteurs pour suivre et cibler CDK5/p25 dans le glioblastome." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONT3513/document.

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CDK5 est une protéine kinase exprimée de façon ubiquitaire et activée principalement dans le système nerveux central, ou elle joue un rôle important dans la transmission synaptique, la guidance axonale et la migration cellulaire, la plasticité synaptique et le développement neuronal. CDK5 est associée à la protéine p35 au niveau de la membrane cellulaire, et activée par clivage calpaine-dépendant de cette dernière en p25, ce qui conduit à la relocalisation de CDK5/p25 dans le cytoplasme cellulaire. CDK5/p25 phosphoryle de nombreux substrats dont la protéine Tau, contribuant ainsi à l’apparitio

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14

Shen, Hung-chang, and 沈宏璋. "Study of 2,5- dihydroxyacetophenone on inhibition of tyrosinase activity and melanogenesis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06225043509635147186.

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碩士<br>國立臺南大學<br>生物科技學系碩士班<br>99<br>In this study, zebrafish and mice will be our animal model. Through the initial screening found a natural acetophenone compound, 2,5-dihydroxyacetophenone (2,5-DHAP) in zebrafish embryos to inhibit melanin biosynthesis results. In a progress reaserch, using B16 melanoma cell to analysis the mechanism of inhitibion of melanogenesis which is found that 2,5-DHAP has the abibility of depigment. 2,5-DHAP was identified as murine tyrosinase inhibitors. The inhibitory activity of 2,5-DHAP is stronger than the skin-whitening standard, arbutin, but slightly lower than

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15

Lin, Jhih-Sheng, and 林志昇. "Effect of mycelial extracts on tyrosinase activity inhibition by Ganoderma lucidum." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/55836862550904973530.

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碩士<br>東海大學<br>化學工程與材料工程學系<br>98<br>Because tyrosinase is a key enzyme to the synthesis of melanin, tyrosinase inhibitors are considered to be effective to cosmetic skin-whitening. The purpose of this study is to investigate the effectiveness of tyrosinase inhibitors prepared from the mycelia of Ganoderma lucidum in submerged cultures and solid-state fermentations. Different extracts of mycelium and fermentation broths were compared for the inhibitory effect of tyrosinase activity. The experiment could be categorized mainly into four parts, which were the comparison of various fermented product

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16

Wu, Chiu-Hui, and 吳秋慧. "Inhibition on Tyrosinase Activity and Melanoma Cell Growth by Bovine Colostrum Hydrolysates." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/34456730213949393249.

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碩士<br>大葉大學<br>生物產業科技學系<br>100<br>In recent years, there is an increasing interest in finding natural tyrosinase inhibitors from animals, plants and microorganisms. The tyrosinase inhibitors should have broad applications, especially, in food, medicinal and cosmetics products in relation to hyperpigmentation. This research used the bovine colostrums collected on the first to fifth days postpartum and normal milk to prepare skimmed colostrums and skimmed normal milk, and used two different enzymes, Alcalase and α-Chymotrypsin, to hydrolyze the samples, followed by investigating the inhibition of

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17

Lin, Chi-Wei, and 林季緯. "Synthesis and Evaluation of Novel Zingerol Derivatives on Tyrosinase Inhibition and Antioxidant Activity." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/49s4vb.

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碩士<br>弘光科技大學<br>化妝品科技研究所<br>103<br>In this study, we synthesized four zingerol derivatives from hydroxybenzoic acids and evaluated their tyrosinase inhibition and antioxidant activities in order to determine the bioactivity of zingerol and the four derivatives. Zingerol shows no significant inhibitory effect on mushroom tyrosinase in 10 mM concentration. IC50 value of tyrosinase inhibition of β-arbutin used as a control group is 5.48 mM. Zingerol has great antioxidant activities and the IC50 values of ABTS and DPPH are 102.84 and 73.13 μM, respectively. Vitamin C is used as a control group and

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18

Zhang, Yong-Qing, and 張詠晴. "Studies on components of Dunaliella salina extracts and their inhibition of tyrosinase activity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ft59e8.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>105<br>Dunaliella salina is an algae rich in natural carotenoids. This study was focused on the anti-oxidation activity and inhibition of tyrosinase activity of Dunaliella salina . In the first part, the carotenoids in the Dunaliella salina were isolated and purified as main components as lutein, zeaxanthin, α-carotene, trans-β-carotene and 9-cis-β-carotene by high performance liquid chromatography. The 9-cis-β-carotene was the most abundant part of carotenoids in Dunaliella salina. The results showed that the antioxidant activity of 9-cis-β-carotene was the best

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19

Li, Kun-Mu, and 李昆穆. "The Antioxidative Activity and Tyrosinase Inhibition of Hydrosols Extracted from Cinnamomum osmophloeum Leaves." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/81391113605240785111.

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碩士<br>大葉大學<br>生物產業科技學系<br>103<br>The Taiwanese Cinnamomum (Cinnamomum osmophloeum Kanehira) can be consumed as food, used medically and as cosmetics. It belongs in the same genus as the cassia tree (cinnamon), and an evergreen tree of the Lauraceae family endemic to Taiwan. This research uses the leaves of the Taiwanese Cinnamomum as raw material to investigate the application of its hydrosol at different distillation stage on whitening emulsion. Analysis focused on the extracted hydrosol’s anti-oxidation ability, tyrosinase activeness and total hardness were conducted, as well as activeness a

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20

ming, chiue chuang, and 闕壯銘. "Inhibition of the Water Extract from Toona sinensis toward the Activity of Tyrosinase." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/22927394746232132969.

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碩士<br>亞洲大學<br>生物科技學系碩士班<br>95<br>In living organisms, melanin can be formed by enzymatic reaction of tyrosinase with certain substrates such as L-3,4-dihydroxyphenylalanine (L-dopa) or L-tyrosine. In this study, we determined the effects of water extract from the leave of Toona sinensis (TSL-CE), the supernatant of the water extract (TSL-1) and the supernatant of the water extract from the fermented leaves (TSL-1 F) on the activities of mushroom tyrosinase toward L-dopa or L-tyrosine to evaluate the potential of using Toona sinensis as the source of skin health products. The activity of tyrosi

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21

Lee, Sheng-Hung, and 李勝宏. "Synthesis and evaluation of novel 2-mercaptoimidazole derivatives on inhibition of tyrosinase activity." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/akdfyc.

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碩士<br>弘光科技大學<br>化妝品應用研究所<br>106<br>Tyrosinase is an important enzyme in the production of melanin. The inhibition of tyrosinase activity can reduce the production of melanin. Previous research indicates that the structure of compounds containing sulfur and nitrogen atoms may inhibit the activity of tyrosinase. Therefore, we design and synthesis the compounds containing 2-mercaptoimidazole moiety in this study. This thesis is divided into two parts. The first part is the synthesis of five methimazole-dipeptides and evaluation of intracellular melanin inhibition in the B16/F10 murine melanoma ce

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22

YANG, KE-HSIN, and 楊哿忻. "Development and evaluation of kojic acid-thiocarbonyl derivatives on inhibition of tyrosinase activity and melanogenesis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ncbh32.

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碩士<br>弘光科技大學<br>化妝品應用研究所<br>107<br>Tyrosinase is the key enzyme in the process of producing melanin in the skin. Therefore by inhibiting the activity of tyrosinase will reduce the production of melanin and make the skin whiter. Kojic acid is a well-known whitening agent that can chelate with copper ions in the active center of tyrosinase to suppress the formation of melanin. Previous research indicates that structures contained sulfur and nitrogen atoms can enhance the inhibitory effect of tyrosinase. Therefore, we design and synthesis the kojic acid derivatives and evaluate their inhibitory e

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23

Jhuang, Ya Wun, and 莊雅雯. "Studies on component analysis and antioxidant charactersization and inhibition of tyrosinase activity of persimmon peel extracts." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/35505013283161594167.

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碩士<br>國立嘉義大學<br>食品科學系研究所<br>95<br>In this study, persimmon (Bull Heart persimmon, Diospyrous kaki L.) was harvested subject to the process of removing astringency from October to Novermber (2005-2006) and was peeled from persimmon fruits process. The persimmon peels was employed as the raw material. The persimmon peel was pulverized after different drying methods. The peel was extracted with water/ethanol extraction, lyophilized and pulverized. Content of total phenolic and flavonoids and the inhibitory effect on linoleic acid autoxidation for the extractions was determined. Results indicated

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Tsai, Mei-Lin, and 蔡美琳. "Study on the inhibition of tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/00837741901040186458.

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碩士<br>元智大學<br>生物科技與工程研究所<br>98<br>Tyrosinase is the main enzyme in the formation of melanin, currently, most researches use tyrosine inhibitors to inhibit the function of this enzyme so as to reduce the production of melanin to achieve whitening effect. Therefore, the whitening agents of skin care products available in the market mostly based on the mechanism of the inhibition of Tyrosinase activity in the formation process of melanin. Many effective ingredients in Ganoderma lucidum and other mushrooms species such as Antrodia cinnamomea, Agaricus blazei Murrill, Hericium erinaceus , Cord

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Braga, Tiago Filipe Roque. "Evaluation of the antioxidant activity and antitumor activity of marine invertebrates extracts." Master's thesis, 2014. http://hdl.handle.net/10400.1/8421.

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Dissertação de Mestrado, Biologia Marinha, Faculdade de Ciências e Tecnologias, Universidade do Algarve, 2014<br>A saúde Humana é tema de grande importância, merecendo assim uma enorme atenção por parte da comunidade científica. As condições ambientais às quais o Homem se encontra sujeito nos dias de hoje, como por exemplo os agravados níveis de poluição e intensos níveis de radiação UV, são por si só potenciais causadores de inúmeros distúrbios e condições perigosas que podem facilmente evoluir para doenças, muitas delas irreversíveis e até mesmo incuráveis. Em associação aos hábitos de vida

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26

Yi, Wang Huei, and 王惠儀. "Effect of Water and Ethanol Extracts from 52 Chinese Herbal Medicines on Inhibition of Tyrosinase Activity and Free-radical generation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/31616393394656014935.

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碩士<br>亞洲大學<br>生活應用科學學系碩士班<br>95<br>Diabetes is caused by the inadequate secretion or malfunctioning of insulin in the patient’s body, which reduces the utilization of carbohydrate even to the extent of complete inability to use it, which then causes high reading of blood sugar as well as sugar in the urine, at the same time causing the metabolism of protein and fat to be abnormal. Medical nutrition therapy is an essential part of the diabetes care and administration program. Although it is most challenging to follow the Diabetes Mellitus diet, it is without doubt that Medical nutrition therapy

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27

Wei-Hao, Chang, and 章偉浩. "Comparisons of ursolic and rosmarinic acid content, antioxidant activity, tyrosinase inhibition in Mesona procumbens callus and ten kinds of Lamiaceae plants." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/08906149677125526079.

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碩士<br>大同大學<br>生物工程研究所<br>94<br>The rosmarinic and ursolic acid content, antioxidant and tyrosinase inhibition activity in Mesona procumbens callus and ten kinds of Lamiaceae plants were examed in this study. The highest content of rosmarinic acid（112.98±0.05 mg/g DW）was obtained from the callus induced from stem explant of Mesona procumbens on MS media supplemented with 4 mg/l NAA or 0.5 mg/l KIN .This result was the same as the wild inflorescence of Solenostemon scutellarioides (red leaf). The contant of rosmarinic acid in cells raised to 129.61±3.24 mg/g DW when cells transfered to the same

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Ko, Arethusa, and 柯昭宇. "The Study on Antioxidative and Tyrosinase-Inhibiting Activity of New Resveratrol Analogues." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/08768157262265035512.

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碩士<br>國立嘉義大學<br>生物藥學研究所<br>95<br>Resveratrol (3,4’,5-trihydroxy-trans-stilbene), a natural phytoalexin present in grapes and other dietary plants, has been suggested as a potential cancer chemopreventive and chemotherapetic agent. This triphenolic stilbene possesses strong antioxidative and anticancer activities. We synthesized a series of resveratrol derivatives with different number or position of hydroxyl group, or with C-4’-halogen-substituents, and examined their biological properties by two systems: (1) antioxidative activity assay, and (2) tyrosinase inhibition assay. In the extracellul

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Kung, Yu-Jung, and 龔玉蓉. "The application of plant extracts with potent tyrosinase inhibition activites on whitening cosmetics." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/19216771135086541777.

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碩士<br>嘉南藥理科技大學<br>生物科技系暨研究所<br>94<br>Abstract The goal of the thesis is to evaluate the application of plant (Chinese medicine plant) extracts with potent tyrosinase inhibition activites on whitening cosmetics. The Mulberry, Glycyrrhiza, and Tree Peony Bark were employed as study materials. The selected plants were extracted by 80 % ethyl alcohols or distilled water by microwave machine, concentrated under a reduced pressure, and then dry by a lyophilizer. The evaluation of the application of herbal extracts on cosmetics includes: (1) suppression activities of melanin synthesis in vitro; (2) a

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(10716546), Panae Noomuna. "INHIBITION OF ERYTHROCYTE BAND 3 TYROSINE PHOSPHORYLATION: CHARACTERIZATION OF A NOVEL THERAPY FOR SICKLE CELL DISEASE AND MALARIA." Thesis, 2021.

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While the molecular defect that cause sickle cell disease has well been established, the cause of vaso-occlusive crisis remains elusive and largely debated upon. Majority of studies have linked the painful episodes to polymerization of sickle hemoglobin following its deoxygenation. The variability of the disease symptoms among patients, compounds efforts for a holistic therapy. Hydroxyurea, a stimulator of Hb F induction and a widely used treatment, has ameliorated the complication of SCD but it is only effective in 50% of the patients. Expression of Hb F lowers the content of Hb S in blood an

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