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Journal articles on the topic 'Tyrosinase inhibition activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Suwunwong, T., T. Kobkeatthawin, K. Chanawanno, N. Saewan, P. Wisitsak, and Suchada Chantrapromma. "Tyrosinase Inhibitory Activity of Pyrazole Derivatives." Advanced Materials Research 506 (April 2012): 194–97. http://dx.doi.org/10.4028/www.scientific.net/amr.506.194.

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A series of 3,5-substituted-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives were synthesized. Their structures were determined on the basis of spectroscopic data interpretation and their tyrosinase inhibitory activity was determined. The results showed that compound 2 (at 1.00 mg/mL) exhibits significant tyrosinase inhibitory activity with % inhibition of 91.866 ± 2.086 with L-tyrosine as substrate whereas compound 3 (at 1.00 mg/mL) exhibits significant tyrosinase inhibitory activity with % inhibition of 79.266 ± 0.552 and 89.593 ± 1.015 with L-tyrosine and L-DOPA as substrates. The IC50v

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2

Kubo, Isao, Qing-Xi Chen, Ken-Ichi Nihei, José S. Calderón, and Carlos L. Céspedes. "Tyrosinase Inhibition Kinetics of Anisic Acid." Zeitschrift für Naturforschung C 58, no. 9-10 (2003): 713–18. http://dx.doi.org/10.1515/znc-2003-9-1021.

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AbstractAnisic acid (p-methoxybenzoic acid) was characterized as a tyrosinase inhibitor from aniseed, a common food spice. It inhibited the oxidation of l-3,4-dihydroxyphenylalanine (ʟ- DOPA) catalyzed by tyrosinase with an IC50 of 0.60 mᴍ. The inhibition of tyrosinase by anisic acid is a reversible reaction with residual enzyme activity. This phenolic acid was found to be a classical noncompetitive inhibitor and the inhibition constant KI was obtained as 0.603 mᴍ. Anisic acid also inhibited the hydroxylation of ʟ-tyrosine catalyzed by tyrosinase. The lag phase caused by the monophenolase acti

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3

Hwang, YeJi, Jieun Lee, Hee Jin Jung, et al. "A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[d]thiazoles: In Vitro and In Silico Insights." Antioxidants 11, no. 7 (2022): 1375. http://dx.doi.org/10.3390/antiox11071375.

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Sixteen compounds bearing a benzothiazole moiety were synthesized as potential tyrosinase inhibitors and evaluated for mushroom tyrosinase inhibitory activity. The compound 4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)benzene-1,3-diol (compound 1b) exhibited the highest tyrosinase activity inhibition, with an IC50 value of 0.2 ± 0.01 μM (a potency 55-fold greater than kojic acid). In silico results using mushroom tyrosinase and human tyrosinase showed that the 2,4-hydroxyl substituents on the phenyl ring of 1b played an important role in the inhibition of both tyrosinases. Kinetic studies on mus

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4

Goenka, Shilpi, Francis Johnson, and Sanford R. Simon. "Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells." Biomolecules 11, no. 5 (2021): 674. http://dx.doi.org/10.3390/biom11050674.

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Skin hyperpigmentation disorders arise due to excessive production of the macromolecular pigment melanin catalyzed by the enzyme tyrosinase. Recently, the therapeutic use of curcumin for inhibiting tyrosinase activity and production of melanin have been recognized, but poor stability and solubility have limited its use, which has inspired synthesis of curcumin analogs. Here, we investigated four novel chemically modified curcumin (CMC) derivatives (CMC2.14, CMC2.5, CMC2.23 and CMC2.24) and compared them to the parent compound curcumin (PC) for inhibition of in vitro tyrosinase activity using t

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5

No, Jae Kyung, Min Sun Kim, You Jung Kim, Song Ja Bae, Jae Sue Choi, and Hae Young Chung. "Inhibition of Tyrosinase by Protocatechuic Aldehyde." American Journal of Chinese Medicine 32, no. 01 (2004): 97–103. http://dx.doi.org/10.1142/s0192415x04001801.

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The purpose of this study was to determine the inhibitory action of protocatechuic aldehyde (PCA) on tyrosinase activity. PCA is one of the compounds found in the root of Salvia miltiorrhiza. Our study documented that PCA has a potent inhibitory effect on tyrosinase, which catalyzes the rate-limiting step of melanin biosynthesis. Although melanin biosynthesis has an essential function normally in human skin for defense against ultraviolet light of the sun, its abnormal activity as seen in pigmentation disorder could lead to serious medical problems. Our data showed that PCA, with concentration

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6

Thailan, V., M. Parvadhavardhani, M. Geethalakshmi, and S. Jayashree. "Extraction of Barleria prionitis (root) and evaluation of tyrosinase inhibition activity." Research Journal of Biotechnology 20, no. 4 (2025): 33–40. https://doi.org/10.25303/204rjbt033040.

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The present study evaluated the tyrosinase inhibition activity and antioxidant activity for Vitiligo (pale white patches) disease by using Barleria prionitis (root) extracts with solvent extracts of ethyl acetate. The tyrosinase inhibition activity of the extracts was determined by inhibition concentration (IC50 values). Results showed that ethyl acetate had the highest tyrosinase inhibition activity by decreasing the percentage of inhibition concentration. The extracts' antioxidant activities were assessed by scavenging 1,1-diphenyl-2- picrylhydrazyl radicals (DPPH test). The results showed t

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7

Lee, Sanggwon, Heejeong Choi, Yujin Park, et al. "Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety." International Journal of Molecular Sciences 22, no. 11 (2021): 5616. http://dx.doi.org/10.3390/ijms22115616.

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We previously reported (E)-β-phenyl-α,β-unsaturated carbonyl scaffold ((E)-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of the scaffold resulted in the greatest tyrosinase inhibitory activity. To examine whether the 4-substituted resorcinol moiety could impart tyrosinase inhibitory activity in the absence of the α,β-unsaturated carbonyl moiety of the (E)-PUSC scaffold, 10 urolithin derivatives were synthesized. To obtain more candidate samples, the lactone ring in synthesized urol

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8

Huang, Yaru, Jiefang Yang, Yunyang Chi, et al. "Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism." Molecules 27, no. 17 (2022): 5558. http://dx.doi.org/10.3390/molecules27175558.

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We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated their inhibition constants. We synthesized 2-(2,6-dimethylhepta-1,5-dien-1-yl)quinazolin-4(3H)-one (Q1) from the natural citral. The concentration, which led to 50% activity loss of Q1, was 103 ± 2 μM (IC50 = 103 ± 2 μM). Furthermore, we considered Q1 to be a mixed-type and reversible tyrosinase inhibitor, and determined the KI and KIS inhibition constants to be 117.07 μM and 423.63 μM, respectively. Our fluorescence experiment revealed that Q1 could interact with the substrates of tyrosine and L-DOPA in

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9

Batubara, Irmanida, Maily Mustofa, Wulan Tri Wahyuni, et al. "Tyrosinase Inhibition, Antiglycation, and Antioxidant Activity of Xylocarpus granatum." Biosaintifika: Journal of Biology & Biology Education 12, no. 1 (2020): 70–75. http://dx.doi.org/10.15294/biosaintifika.v12i1.22676.

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Xylocarpus granatum is mangrove plant that traditionally used as face powder in Central Sulawesi, Indonesia which related to antioxidant, antiglycation and tyrosinase inhibition activities. This study aimed to evaluate the potency of X. granatum as a tyrosinase inhibitor, antiglycation, and antioxidant. The leaves, stem, stem bark, fruit flesh, fruit peel, and kernel of X. granatum were extracted using ethanol then their tyrosinase inhibition, antiglycation, and antioxidant were evaluated. Tyrosinase inhibition activity was evaluated using in vitro assay with L-tyrosine and L-DOPA as the subst

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10

Fatharani, Raihana Mufliha, Ula Aulia Fitrian, Sumail Sidik Ode Ishak, and Amirah Adlia. "Sun protection factor and tyrosinase inhibitory activity of several plant secondary metabolites." Current Research on Biosciences and Biotechnology 5, no. 1 (2023): 315–19. http://dx.doi.org/10.5614/crbb.2023.5.1/vclq3adv.

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Severe exposure to ultraviolet (UV) rays leads to skin damage, including hyperpigmentation, freckles, melanoma, age spots, and melasma, all of which are related to the skin pigment enzyme, tyrosinase. Prevention can be achieved by avoiding harsh UV rays and inhibiting tyrosinase catalytic activity. Many compounds have been developed for the treatment of such conditions; however, most come with unwanted side effects. The purpose of this study was to determine the sun protection factor (SPF) value and tyrosinase enzyme inhibitory activity of plant secondary metabolites with high antioxidant acti

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11

Baek, Seung-Hwa, Myung-Gyun Kang, and Daeui Park. "Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses." Current Pharmaceutical Biotechnology 21, no. 2 (2020): 169–78. http://dx.doi.org/10.2174/1389201020666191011151123.

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Background: Melanin protects the skin against the harmful effects of ultraviolet irradiation. However, melanin overproduction can result in several aesthetic problems, including melasma, freckles, age spots and chloasma. Therefore, development of anti-melanogenic agents is important for the prevention of serious hyperpigmentation diseases. Sesamolin is a lignan compound isolated from sesame seeds with several beneficial properties, including potential for melanin inhibition. Objective: The aim of this study was to evaluate the anti-melanogenic effect of sesamolin in cell culture in vitro and t

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12

Laksmiani, Ni Putu Linda, I. Komang N. Sanjaya, and Ni Putu E. Leliqia. "The activity of avocado (Persea americana Mill.) seed extract containing catechin as a skin lightening agent." Journal of Pharmacy & Pharmacognosy Research 8, no. 1 (2020): 449–56. http://dx.doi.org/10.56499/jppres20.836_8.5.449.

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Context: Indonesia is a tropical country with high UV rays. UV rays can increase melanin synthesis in the skin and cause the skin to become darker and hyperpigmented. One way to overcome this problem is the use of skin lightening agents through the mechanism of tyrosinase inhibition. Flavonoids have antioxidant activity and inhibit the process of melanogenesis. Also, avocado seeds contain secondary metabolites of flavonoids in the form of catechin. Aims: To determine the potential and activity of catechin as skin lightening agent against the target protein, tyrosinase, by in silico test using

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13

Lee, Hee-kyung, On-you Choi та DuBok Choi. "차나무 뿌리에서 분리한 조사포닌의 산화적스트레스 억제 및 미백효과". Association for International Tea Culture 59 (30 березня 2023): 1–28. http://dx.doi.org/10.21483/qwoaud.59..202303.1.

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The aim of this research was to investigate the inhibitory effects of oxidative stress, tyrosinase, L-DOPA auto-oxidation, and melanogenesis for whitening effect using tea plant root’s crude saponin. The inhibitory effects of oxidative stress, tyrosinase, L-DOPA auto-oxidation, and melanogenesis increased depending on the concentration of tea plant root's crude saponin. when the concentration of tea plant root’s crude saponin was increased from 50 µg/mL. to 500 µg/mL with SNP 0.3 mM, the survival rate of HepG2 cell was increased from 57.58% to 65.78%, which was about 1.36 fold increase compare

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14

Lopez-Tejedor, David, Rafael Claveria-Gimeno, Adrian Velazquez-Campoy, Olga Abian, and Jose M. Palomo. "In Vitro Antiviral Activity of Tyrosinase from Mushroom Agaricus bisporus against Hepatitis C Virus." Pharmaceuticals 14, no. 8 (2021): 759. http://dx.doi.org/10.3390/ph14080759.

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Tyrosinases from a commercial Agaricus bisporus protein extract and directly isolated from white mushrooms were purified in order to obtaining the well-known tyrosinase from A. bisporus (TyrAB) of 45 kDa and a newly discovered 50 kDa tyrosinase isoform (Tyr50 kDa), and tested showing high antiviral activity against the hepatitis C virus for the first time. Cell toxicity and antiviral activity of tyrosinases were determined in cultured Huh 5-2 liver tumor cells transfected with a replicon system (a plasmid that includes all non-structural hepatitis C virus proteins and replicates autonomously).

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15

Batubara, Irmanida, Yuni Kartika, and Latifah K. Darusman. "Relationship between Zingiberaceae Leaves Compounds and its Tyrosinase Activity." Biosaintifika: Journal of Biology & Biology Education 8, no. 3 (2016): 371. http://dx.doi.org/10.15294/biosaintifika.v8i3.6742.

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<p>The leaves of Zingiberaceae family has not been much explored its potential, especially as a skin whitener. The relationship between total anthocyanins, chlorophyll, carotenoids and tannins contents of <em>Zingiberaceae </em>leaves and tyrosinase activity were determined. Ten species of <em>Zingiberaceae </em>were separated by <em>n</em>-hexane and the residues were extracted with ethyl acetate. The total anthocyanins, chlorophyll, carotenoids, tannins contents and the activities of ethyl acetate extracts were determined by spectrometric method. The

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16

Liu, Jiaman, Yuqing Liu, Xiaofeng He, Bo Teng, and Jacqui M. McRae. "Valonea Tannin: Tyrosinase Inhibition Activity, Structural Elucidation and Insights into the Inhibition Mechanism." Molecules 26, no. 9 (2021): 2747. http://dx.doi.org/10.3390/molecules26092747.

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Valonea tannin is a natural product readily extracted from acorn shells that has been suggested to have potential skin whitening properties. This study investigated the tyrosinase inhibition activity of extracted valonea tannin and the associated structure–function activity. Nuclear magnetic resonance spectroscopy and molecular weight analysis with gel permeation chromatography revealed that valonea tannin could be characterized as a hydrolysable tannin with galloyl, hexahydroxydiphenoyl and open formed-glucose moieties and an average molecular weight of 3042 ± 15 Da. Tyrosinase inhibition ass

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17

Ningsih, Indah Yulia, Lisa Kusuma Wardhani, Annisa Ragdha Eka Nuryuanda, Endah Puspitasari, and Mochammad Amrun Hidayat. "Genistein Content and Tyrosinase Inhibitory Activity of Edamame (Glycine max) Extracts." Journal of Tropical Pharmacy and Chemistry 6, no. 2 (2022): 92–100. http://dx.doi.org/10.25026/jtpc.v6i2.461.

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The study aimed to determine genistein content and tyrosinase inhibition activity of 70% ethanolic and ethyl acetate extracts of edamame (Glycine max) with an extraction time of 15, 30, and 60 minutes. Extraction was performed using the ultrasonication method. Determination of genistein content was carried out using TLC-densitometry. Furthermore, all samples were tested for their tyrosinase inhibition activity using the spectrophotometric assay. Ethyl acetate extract with 60 min of extraction time exhibited the highest extraction yield (6.414% w/w), the highest genistein content (0.169 ± 0.007

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18

Matos, Patrícia, António Paranhos, Maria Teresa Batista, and Artur Figueirinha. "Synergistic Effect of DIBOA and Verbascoside from Acanthus mollis Leaf on Tyrosinase Inhibition." International Journal of Molecular Sciences 23, no. 21 (2022): 13536. http://dx.doi.org/10.3390/ijms232113536.

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Overexpression of melanin contributes to darkening of plant and fruit tissues and skin hyperpigmentation, leading to melasma or age spots. Although melanin biosynthesis is complex and involves several steps, a single enzyme known as tyrosinase is key to regulating this process. The melanogenesis pathway is initiated by oxidation of the starting material l-tyrosine (or l-DOPA) to dopaquinone by tyrosinase; the resulting quinone then serves as a substrate for subsequent steps that eventually lead to production of melanin. Medicinal plants are considered a good source of tyrosinase inhibitors. Th

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dwi, fitrah wahyuni wiwi, Nisaa Nurzak An, yunus Arifuddin, and Fhalaq Baso Fajrul. "Skin Brightening Cream Formulation and Tyrosinase Inhibition Assay of Moringa Leaf Extract." International Journal of Pharmaceutical and Bio-Medical Science 02, no. 07 (2022): 187–90. https://doi.org/10.5281/zenodo.6786385.

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<em>Moringa oleifera</em> L. leaves are known to have very high protein content and contain isoflavones, inhibiting tyrosinase activity. The study was conducted to test the tyrosinase inhibitor activity of Moringa leaf extract and to formulate the extract as a skin brightening cream. Research shows that the extract of Moringa leaves has good activity as an inhibitor of tyrosinase and can be developed as a skin brightening cream. The results of the cream formulations showed good cosmetology properties (pH, homogeneity, and spreadibility).

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20

El-Sayed, Ashraf S. A., Hanaa Salah Maamoun, Gamal H. Rabie, et al. "Microbial Tyrosinase: Biochemical, Molecular Properties and Pharmaceutical Applications." Biomedical and Pharmacology Journal 14, no. 3 (2021): 1281–95. http://dx.doi.org/10.13005/bpj/2229.

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Tyrosinase is a copper-containing monooxygenase involved in thecatalysis of the hydroxylation and oxidation reaction of monophenols and diphenols, respectively, into O-quinones intermediates. Tyrosinase is mainly involved in melanogenesis via two reactions. Firstly, 3,4-dihydroxyphenylalanine is produced through tyrosine hydroxylation the nit oxidized into dopaquinone, and finally gives melanin. However, dopaquinones can results in neuronal damage and cell death through the excessive production, suggesting that tyrosinase may be implanted in the formation human brain’s neuromelanin and associa

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21

Choosuwan, Pradtana, Jantana Praiboon, Korawinwich Boonpisuttinant та ін. "Inhibitory Effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on Tyrosinase Activity and α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells". Life 13, № 4 (2023): 934. http://dx.doi.org/10.3390/life13040934.

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Melanogenesis involves a synthesis of melanin pigment and is regulated by tyrosinase. The addition of whitening agents with tyrosinase-inhibiting properties in cosmetics is becoming increasingly important. In this study, the ethanolic extracts from twelve seaweeds were assessed for tyrosinase-inhibiting activity using mushroom tyrosinase and melanin synthesis in B16F10 melanoma cells. The highest mushroom tyrosinase inhibition (IC50) was observed with Lobophora challengeriae (0.15 ± 0.01 mg mL−1); treatment was more effective than kojic acid (IC50 = 0.35 ± 0.05 mg mL−1), a well-known tyrosinas

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22

Lee, Na Young. "Antioxidant Effect and Tyrosinase Inhibition Activity of Seaweeds Ethanol Extracts." Journal of the Korean Society of Food Science and Nutrition 42, no. 12 (2013): 1893–98. http://dx.doi.org/10.3746/jkfn.2013.42.12.1893.

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23

Xiu-Hua, Jia, Lin Shao-Chun, Huang Bing, et al. "Tyrosinase Small Interfering RNA Effectively Suppresses Tyrosinase Gene Expression In Vitro and In Vivo." Molecular Biology International 2010 (November 4, 2010): 1–6. http://dx.doi.org/10.4061/2010/240472.

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Tyrosinase is a bifunctional enzyme which oxidizes the initial step of melanin biosynthesis, that is, conversion of tyrosine to dopa and subsequently dopa to dopaquinone. It is a glycosylated protein and a major regulator of melanogenesis. To date, many approaches have been tried to regulate tyrosinase activity and melanin content. To that end, we screened small interfering RNA sequences for sequence-inhibited tyrosinase expression in B16 cells and in C57BL/6 mice. We analyzed tyrosinase mRNA levels by quantitative real-time PCR and determined tyrosinase activity and melanin content at 24, 48,

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24

Lopes, Thiago Inácio Barros, Roberta Gomes Coelho, and Neli Kika Honda. "Inhibition of Mushroom Tyrosinase Activity by Orsellinates." Chemical and Pharmaceutical Bulletin 66, no. 1 (2018): 61–64. http://dx.doi.org/10.1248/cpb.c17-00502.

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Piao, Long Zhu, Hyang Rae Park, Yun Kyung Park, Seung Ki Lee, Jeong Hill Park, and Man Ki Park. "Mushroom Tyrosinase Inhibition Activity of Some Chromones." CHEMICAL & PHARMACEUTICAL BULLETIN 50, no. 3 (2002): 309–11. http://dx.doi.org/10.1248/cpb.50.309.

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Chilka, Pallavi, Sarah Phillips, and Bhaskar Datta. "DNA template-assisted inhibition of tyrosinase activity." International Journal of Biological Macromolecules 79 (August 2015): 278–83. http://dx.doi.org/10.1016/j.ijbiomac.2015.04.039.

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Piao, Long Zhu, Hyang Rae Park, Yun Kyung Park, Seung Ki Lee, Jeong Hill Park, and Man Ki Park. "Mushroom Tyrosinase Inhibition Activity of Some Chromones." ChemInform 33, no. 35 (2010): 134. http://dx.doi.org/10.1002/chin.200235134.

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Song, Yuqiong, Shengjun Chen, Laihao Li, Yaoxun Zeng, and Xiao Hu. "The Hypopigmentation Mechanism of Tyrosinase Inhibitory Peptides Derived from Food Proteins: An Overview." Molecules 27, no. 9 (2022): 2710. http://dx.doi.org/10.3390/molecules27092710.

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Skin hyperpigmentation resulting from excessive tyrosinase expression has long been a problem for beauty lovers, which has not yet been completely solved. Although researchers are working on finding effective tyrosinase inhibitors, most of them are restricted, due to cell mutation and cytotoxicity. Therefore, functional foods are developing rapidly for their good biocompatibility. Food-derived peptides have been proven to display excellent anti-tyrosinase activity, and the mechanisms involved mainly include inhibition of oxidation, occupation of tyrosinase’s bioactive site and regulation of re

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Athipornchai, Anan, Nattisa Niyomtham, Wachirachai Pabuprapap, et al. "Potent Tyrosinase Inhibitory Activity of Curcuminoid Analogues and Inhibition Kinetics Studies." Cosmetics 8, no. 2 (2021): 35. http://dx.doi.org/10.3390/cosmetics8020035.

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Natural tyrosinase inhibitors from herbal plants are promising therapeutic agents for skincare and cosmetic products. Natural curcuminoids exhibit weak antityrosinase properties. The structural modification of curcumin, the major curcuminoid from Curcuma longa, gave 14 analogues. The tyrosinase inhibitory activity of the natural curcuminoids and the modified analogues on both L-tyrosine and DOPA substrates were evaluated. The inhibition kinetics were also undertaken. For analogues with potent activity on the L-tyrosine substrate, the isoxazole analogue 12 and two reduced analogues, hexahydrocu

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Hartanti, Lanny, and Henry Kurnia Setiawan. "INHIBITORY POTENTIAL OF SOME SYNTHETIC CINNAMIC ACID DERIVATIVES TOWARDS TYROSINASE ENZYME." Indonesian Journal of Chemistry 9, no. 1 (2010): 158–68. http://dx.doi.org/10.22146/ijc.21579.

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Cinnamic acid is one of known tyrosinase inhibitors. This study investigated the inhibition of tyrosinase activity of some cinnamic acid derivatives, i.e. 4-buthoxy-cinnamic acid, 4-n-butylcinnamic acid and 4-phenylcinnamic acid. Each inhibitor used in this research had the same type of inhibition towards enzymatic activity, i.e. mixed type inhibition of competitive and non competitive type. The potential sequence of tyrosinase inhibition based on the ratio of its IC50 compared to cinnamic acid, from the lowest to the highest were 4-buthoxycinnamic acid, 4-phenylcinnamic acid and 4-n-butylcinn

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Muruganandam, Aishwarya Raju, Sivasankari Venkatasubramanian, Shail Adrian Jagmag, and Veerabhuvaneshwari Veerichetty. "Antityrosinase Activity of Phycocyanin and Cream Formulation for Hyperpigmentation." IOP Conference Series: Materials Science and Engineering 1291, no. 1 (2023): 012039. http://dx.doi.org/10.1088/1757-899x/1291/1/012039.

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Abstract Free radicals are involved in the catalytic reactions of tyrosinase to give dopaquinone in melanin biosynthesis. Screening of molecules with antioxidant activity from natural sources which inhibit tyrosinase has become important for cosmetic and medicinal topical products. Tyrosinase inhibitors are used in treating hyperpigmentation. Synthetic tyrosinase inhibitors possess side effects such as skin irritation, dermatitis, dryness, and inflammatory reaction. The objective of the study is to evaluate the tyrosinase inhibition potential of phycocyanin, which is a pigment extracted from t

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32

Tripathi, R. K., C. Chaya Devi, and A. Ramaiah. "pH-dependent interconversion of two forms of tyrosinase in human skin." Biochemical Journal 252, no. 2 (1988): 481–87. http://dx.doi.org/10.1042/bj2520481.

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1. We have shown that the characteristic lag in cresolase activity of human skin tyrosinase at inhibitory concentration of tyrosine was absent at all pH values studied, i.e. pH 5.2, 5.7, 6.2 and 6.8, if the enzyme solubilized at low pH was used as the source of enzyme, but the same enzyme when dialysed against buffers of various pH values showed linear activity only at pH 5.2 and was not inhibited by excess tyrosine, whereas at higher pH values it exhibited a lag and inhibition by excess tyrosine. 2. However, the enzyme solubilized in buffer/detergent, pH 6.8, when dialysed against buffer of t

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Thaha, Anthony, Bor-Sen Wang, Yu-Wei Chang, et al. "Food-Derived Bioactive Peptides with Antioxidative Capacity, Xanthine Oxidase and Tyrosinase Inhibitory Activity." Processes 9, no. 5 (2021): 747. http://dx.doi.org/10.3390/pr9050747.

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Bioactive peptides (BPs) released by proteases from different food protein sources are often served as antioxidants in food applications. This study aims to investigate 11 BPs derived from fish and egg white as potential natural antioxidants by antioxidant activity assays. The kinetic activity of the BPs against xanthine oxidase (XOD) and tyrosinase was also analyzed. The antioxidative capacity of the BPs indicated that VWWW (VW4, mackerel meat), followed by IRW (IW3, egg white) and VKAGFAWTANQQLS (VS14, tuna backbone protein), possessed the highest antioxidant activity in 1,1-diphenyl-2-picry

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YONGPRADOEM, Panadda, and Natthida WEERAPREEYAKUL. "Evaluation of Antioxidant Activity and Inhibition of Tyrosinase Activity of Raphanus sativus var. caudatus Alef Extract." Walailak Journal of Science and Technology (WJST) 17, no. 8 (2020): 838–50. http://dx.doi.org/10.48048/wjst.2020.5541.

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This study was aimed to determine antioxidant and tyrosinase inhibition effects of the pod of Raphanus sativus L. var. caudatus Alef extract. The compounds consisted in the extracts were identified by HPLC from standard peak comparison. Pod was extracted by using 2 different solvents-dichloromethane (DCM) and water. The antioxidant activity was evaluated based on free radical scavenging (DPPH) activity and ferric reducing ability (FRAP) assay. The lightening effect was determined from the inhibition of mushroom tyrosinase in vitro. The results showed that DCM extract contained sulforaphene, pr

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Goenka, Shilpi, and Sanford R. Simon. "CMT-308, a Nonantimicrobial Chemically-Modified Tetracycline, Exhibits Anti-Melanogenic Activity by Suppression of Melanosome Export." Biomedicines 8, no. 10 (2020): 411. http://dx.doi.org/10.3390/biomedicines8100411.

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CMT-308 is a nonantimicrobial chemically-modified tetracycline (CMT), which we have previously shown exhibits antifungal activity and pleiotropic anti-inflammatory activities, including inhibition of the enzymatic activity of matrix metalloproteinases (MMPs). Based on its chemical structure, we hypothesized that CMT-308 could inhibit melanogenesis and might be a candidate for the treatment of skin hyperpigmentation disorders which occur due to unregulated melanin biosynthesis and/or transport. CMT-308 was first studied for any effects on activity of the enzyme tyrosinase in vitro using a purif

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Masuri, Sebastiano, Benedetta Era, Francesca Pintus, et al. "Design, Synthesis, Structural Insights, Tyrosinase Inhibition, and Sun Protection Factor of New Thiosemicarbazone Derivatives." Molecules 29, no. 23 (2024): 5629. http://dx.doi.org/10.3390/molecules29235629.

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Tyrosinase, a key protein in the biosynthesis of melanin pigments, is crucial in determining skin pigmentation. Inhibiting tyrosinase activity is a promising approach for treating conditions related to excessive pigmentation. For the synthesis of more potent tyrosinase inhibitors, we combined two approaches, para-substitution and lipophilicity, to enhance the inhibitory properties of (E)-2-(4-hydroxybenzylidene)hydrazine-1-carbotiamide, whose enzyme inhibitory properties have been previously demonstrated. The newly synthesized compounds showed potent inhibition activity against tyrosinase in t

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Duletić-Laušević, Sonja, Aradski Ana Alimpić, Jelena Živković, et al. "Evaluation of bioactivities and phenolic composition of extracts of Salvia officinalis L. (Lamiaceae) collected in Montenegro." Botanica Serbica 43, no. 1 (2019): 47–58. https://doi.org/10.2298/BOTSERB1901047D.

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Sage (Salvia officinalis) is the best-known species of the genus Salvia, due to its medicinal and flavouring properties. This research was conducted on samples of S. officinalis collected from Potoci (SOP) in the continental part of Montenegro and from Valdanos (SOV) and Lu&scaron;tica (SOL) in the country ́s coastal region. Extracts prepared using 96% ethanol, 50% ethanol and hot distilled water were examined for phenolic composition, as well as for their antioxidant, enzyme-inhibiting and cytotoxic activities. The HPLC-DAD method was employed for quantitative-qualitative analysis of phenolic

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Wijaya, Caroline, Berna Elya, and Arry Yanuar. "STUDY OF TYROSINASE INHIBITORY ACTIVITY AND PHYTOCHEMICAL SCREENING OF CASSIA FISTULA L. LEAVES." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 384. http://dx.doi.org/10.22159/ijap.2018.v10s1.85.

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Objective: This study was carried out to evaluate the phytochemical constituents and tyrosinase inhibitory activity of Cassia fistula leaves.Methods: A tyrosinase inhibitory activity assay was performed by measuring the decrease in the intensity of color suggestive of the inhibition ofdopachrome formation resulting from the L-DOPA-tyrosinase reaction.Results: The test results showed that the tyrosinase inhibitory activity of the water fraction of C. fistula leaf extract had the highest IC50 value(152.031 μg/mL) among other fractions (n-hexane, ethyl acetate, and n-butanol). An enzyme kinetic a

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Jung, Hee Jin, Hyeon Seo Park, Hye Soo Park, et al. "Exploration of Compounds with 2-Phenylbenzo[d]oxazole Scaffold as Potential Skin-Lightening Agents through Inhibition of Melanin Biosynthesis and Tyrosinase Activity." Molecules 29, no. 17 (2024): 4162. http://dx.doi.org/10.3390/molecules29174162.

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Inspired by the potent tyrosinase inhibitory activity of phenolic compounds with a 2-phenylbenzo[d]thiazole scaffold, we explored phenolic compounds 1–15 with 2-phenylbenzo[d]oxazole, which is isosterically related to 2-phenylbenzo[d]thiazole, as novel tyrosinase inhibitors. Among these, compounds 3, 8, and 13, featuring a resorcinol structure, exhibited significantly stronger mushroom tyrosinase inhibition than kojic acid, with compound 3 showing a nanomolar IC50 value of 0.51 μM. These results suggest that resorcinol plays an important role in tyrosinase inhibition. Kinetic studies using Lin

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Liu, Jiaman, Yanbiao Chen, Xinxin Zhang, Jie Zheng, Weiying Hu, and Bo Teng. "Hop Tannins as Multifunctional Tyrosinase Inhibitor: Structure Characterization, Inhibition Activity, and Mechanism." Antioxidants 11, no. 4 (2022): 772. http://dx.doi.org/10.3390/antiox11040772.

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The application of hops could be extended to obtain higher commercial values. Tannins from hops were assessed for their tyrosinase inhibition ability, and the associated mechanisms were explored. Nuclear magnetic resonance (NMR) and high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC–ESI–MS/MS) revealed that the hop tannins were characterized as condensed tannins with (epi)catechin and (epi)gallocatechin as subunits and an average polymerization degree of 10.32. Tyrosinase inhibition assay indicated that hop tannins had an IC50 = 76.52 ± 6.56 μM. Kinet

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Kusnaedi, Anggi, Dimas Andrianto, and Syaefudin. "Surface tension and in vitro tyrosinase inhibitory activity of tamanu oil (Calophyllum inophyllum L.)." Buitenzorg: Journal of Tropical Science 1, no. 2 (2024): 20–29. https://doi.org/10.70158/buitenzorg.v1i2.11.

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Tamanu or nyamplung oil, derived from Calophyllum inophyllum L., is commonly used in traditional medicine and occasionally used as a moisturizer in skincare cosmetics. In silico predictions suggested that tamanu oil contained compounds capable of inhibiting tyrosinase activity. This study aimed to measure the surface tension of tamanu oil and evaluate its tyrosinase inhibitory activity in vitro. The surface tension of tamanu oil was measured using the du-Nouy ring method with a tensiometer, while tyrosinase inhibitory activity was assessed by spectrophotometry using a microplate reader. The st

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Li, Jianping, Xiaofeng Min, Xi Zheng, Shaohua Wang, Xuetao Xu, and Jinbao Peng. "Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters." Molecules 28, no. 16 (2023): 5969. http://dx.doi.org/10.3390/molecules28165969.

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Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases. To find potential tyrosinase inhibitors, a series of cinnamic acid–eugenol esters (c1~c29) was synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, HRMS, and FT-IR, respectively. The biological evaluation results showed that all compounds c1~c29 exhibited definite tyrosinase inhibitory activity; especially, compound c27 was the strongest tyrosinase inhibitor (IC50: 3.07 ± 0.26 μM), being ~4.6-fold stronger than the p

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Kim, Hye Jin, Hee Jin Jung, Young Eun Kim, et al. "Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases." Molecules 29, no. 12 (2024): 2887. http://dx.doi.org/10.3390/molecules29122887.

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Based on the fact that substances with a β-phenyl-α,β-unsaturated carbonyl (PUSC) motif confer strong tyrosinase inhibitory activity, benzylidene-3-methyl-2-thioxothiazolidin-4-one (BMTTZD) analogs 1–8 were prepared as potential tyrosinase inhibitors. Four analogs (1–3 and 5) inhibited mushroom tyrosinase strongly. Especially, analog 3 showed an inhibitory effect that was 220 and 22 times more powerful than kojic acid in the presence of l-tyrosine and l-dopa, respectively. A kinetic study utilizing mushroom tyrosinase showed that analogs 1 and 3 competitively inhibited tyrosinase, whereas anal

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Ramli, Salfarina, and Nijsiri Ruangrungsi. "Tyrosinase inhibition, antioxidant activity and total phenolic content of selected Mimosaceae pericarps ethanolic extracts." International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science 4 (June 30, 2021): 47–57. http://dx.doi.org/10.24191/ijpnacs.v4.04.

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The pericarp is the outer layer of a fruit. Often, pericarps are not used and are usually discarded. However, they may have untapped pharmacological potential. This study explored the tyrosinase inhibition, antioxidant activities, and total phenolic content of five pericarp extracts from Mimosacea family, namely Adenanthera pavonina, Archidendron jiringa, Leucaena glauca, Parkia speciosa and Pithecellobium dulce. Ethanolic extract was obtained after continuous extraction of dried pericarp with petroleum ether, dichloromethane and ethanol using Soxhlet apparatus. L-Tyrosine and L-Dopa are the s

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Puspaningtyas, Ayik Rosita. "Evaluation of the effect of red guava (Psidium guajava) fruit extract on tyrosinase (EC 1.14.18.1) activity by spectrophotometry." International Current Pharmaceutical Journal 1, no. 5 (2012): 92–97. http://dx.doi.org/10.3329/icpj.v1i5.10280.

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Tyrosinase is one of the most important enzymes in melanin biosynthesis. Inhibition of tyrosinase activity will cause a decrease in melanin production. Tyrosinase inhibitory activity by ascorbic acid has been studied before. Based on reported experiments, ascorbic acid can inhibit tyrosinase activity in enzymatic reaction competitively. As an effort to find out a skin whitening agent which is effective, safe and have minimum adverse effect, the inhibitory activities of Psidium guajava extract was studied on tyrosinase activity. This is one of the fruits that contains high amount of ascorbic ac

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Suzu, Ikuko, Hiroki Goto, Nami Hiwatashi, et al. "Antioxidant and Antityrosinase Activity of Cissus quadrangularis Extract." Natural Product Communications 8, no. 5 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800522.

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The effects of Cissus quadrangularis Linn. extract on antioxidation and tyrosinase inhibition were investigated. The extract showed anti-oxidative activity with an IC50 value of 522.0 μg/mL, and inhibitory effects on tyrosinase activity and melanin production in B16 melanocytes in a dose-dependent manner (100-2000 μg/mL). This study suggests that this species contains anti-tyrosinase components.

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Mustika, Rina, Siti Hindun, and Nurul Auliasari. "Potensi Tanaman Sebagai Pencerah Wajah Alami." Jurnal Sains dan Kesehatan 2, no. 4 (2020): 558–62. http://dx.doi.org/10.25026/jsk.v2i4.233.

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Melanin is a pigment that gives human skin, hair and eye color. Excessive distribution of pigment malanin can cause skin problems such as hyperpigmentation. One of the principles of handling hyperpigmentation is to inhibit melanin synthesis which can be done by using a depigmentation agent (tyrosinase inhibitor) which has a mechanism of action to inhibit the tyrosinase enzyme. Inhibition of the tyrosinase enzyme can be done by measuring IC50 in a plant. IC50 is the concentration of an inhibitor needed to inhibit half of the enzyme activity. This review aims to compare the IC50 values ??of mono

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Vrianty, Dela, Rismawati Laila Qodariah, Wahyu Widowati, et al. "Comparison of Antioxidant and Anti-Tyrosinase Activities of Pineapple (Ananas comosus) Core Extract and Luteolin Compound." Jurnal Kedokteran Brawijaya 30, no. 4 (2019): 240. http://dx.doi.org/10.21776/ub.jkb.2019.030.04.2.

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Free radicals and UV exposure can cause aging. Aging prevention needs substances that can prevent molecular oxidation reactions in cells and inhibit the activity of enzymes that trigger aging. Research on pineapple skin and flesh extract (Ananas comosus (L.) Merr.) reported the presence of luteolin compound which functions as antioxidants and antityrosinase. However, in this study, the object used was pineapple core extract (PCE), which has not been widely known for its antioxidant and antityrosinase activity. Therefore, the purpose of this study was to determine the content of phytochemical c

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Andrawis, A., and V. Kahn. "Effect of methimazole on the activity of mushroom tyrosinase." Biochemical Journal 235, no. 1 (1986): 91–96. http://dx.doi.org/10.1042/bj2350091.

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Methimazole (1-methyl-2-mercaptoimidazole) inhibits both the mono- and the o-dihydroxyphenolase activities of mushroom tyrosinase when assayed spectrophotometrically. With DL-3,4-dihydroxyphenylalanine as substrate, the inhibition was found to be a mixed-type one with Ki 4.6 × 10(-6) M. We found that methimazole can interact with the oxidation products of o-dihydroxyphenols, probably with o-quinones, to form a conjugate. The conjugate formed between methimazole and o-benzoquinone was separated by chromatography on Sephadex G-10 and was characterized by an absorption maximum at 248-260 nm. Our

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Sholikha, Munawarohthus, and Ainun Wulandari. "Tyrosinase Inhibition Activity and Phytochemical Screening of Melaleuca leucadendron L. Leaves." Borneo Journal of Pharmacy 5, no. 3 (2022): 202–8. http://dx.doi.org/10.33084/bjop.v5i3.3694.

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Melaleuca leucadendron L. is a plant whose almost all parts (bark, leaves, twigs, and fruit) can be used as medicine, such as antioxidants, antifungals, sedative effects, and anti-hyaluronidase. This research was conducted to determine tyrosinase inhibition activity and compound content of M. leucadendron leaves. Maceration of M. leucadendron leaves was done in methanol, then carried out liquid-liquid fractionation with n-butanol, chloroform, and water. Methanol extract, butanol fraction, chloroform fraction, and water fraction were tested for phytochemical screening and tyrosinase inhibition

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