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Dissertations / Theses on the topic 'Tyrosine Kinase (RTK) Pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Peterson, Cornelia WM. "Insulin Stimulates Protein Synthesis via RTK-Induction of the Akt-s6k Pathway in Human and Canine Corneal Cells." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555070124329814.

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2

Koytiger, Grigoriy. "A Systematic Experimental and Computational Approach to Investigating Phosphotyrosine Signaling Networks." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10943.

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Mutation and over-expression of Receptor Tyrosine Kinases (RTKs) or the proteins they regulate serve as oncogenic drivers in diverse cancers. RTKs catalyze the transfer of phosphate from ATP to the hydroxyl group on tyrosine. The proximal stretch of amino acids including this post translational modification is then able to be recognized by SH2 and PTB domains. Chapter 1 details our work to better understand RTK signaling and its link to oncogenesis using protein microarrays to systematically and quantitatively measure interactions between virtually every SH2 or PTB domain encoded in the human

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3

Ahier, Arnaud. "Etude des Récepteurs Tyrosine Kinase du parasite helminthe Schistosoma mansoni - Découverte des Venus Kinase Récepteurs, une nouvelle famille de RTK." Phd thesis, Université du Droit et de la Santé - Lille II, 2008. http://tel.archives-ouvertes.fr/tel-00348172.

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La schistosomiase constitue un problème majeur de santé publique dans de nombreux pays émergents d'Afrique, d'Amérique Latine et d'Asie du Sud Est, causant près de 300 000 décès par an. Cette maladie est due au schistosome qui est un ver parasite possédant un cycle de vie complexe. A ce jour une seule drogue est utilisée en monothérapie, le praziquantel ou PZQ, pour lutter contre cette maladie. En raison d'apparitions de résistances au PZQ, il devient nécessaire de rechercher de nouvelles cibles thérapeutiques contre le ver. Au cours de ma thèse je me suis penché sur l'utilisation potentielle

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Ahier, Arnaud Dissous-Lempereur Colette. "Etude des Récepteurs Tyrosine Kinase du parasite helminthe Schistosoma mansoni découverte des Récepteurs Venus Kinase, une nouvelle famille de RTK /." [S.l.] : [s.n.], 2008. http://tel.archives-ouvertes.fr/tel-00348172/fr.

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Reproduction de : Thèse de doctorat : Parasitologie - Biologie moléculaire : Lille 2 : 2008.<br>Résumé en français et en anglais. RTK = Récepteurs Tyrosine Kinase. Titre provenant de l'écran-titre. Bibliogr. p. 104-118.

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5

Saharinen, Pipsa. "Signaling through the Jak-Stat pathway : regulation of tyrosine kinase activity." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/saharinen/.

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6

Rivera, Reyes Brenda Mariola. "Regulation of the TCR signaling pathway." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1132588714.

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7

Edling, Charlotte. "Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells." Doctoral thesis, Umeå : Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-888.

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8

Gouzi, Jean. "Le récepteur à activité tyrosine kinase ALK : voies de signalisation et rôle dans la différenciation neuronale." Paris 6, 2006. http://www.theses.fr/2006PA066115.

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9

Hurlbut, Gregory Donald. "Notch and RTK signaling : transcriptional output and signal integration." Paris 11, 2007. http://www.theses.fr/2007PA112203.

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10

Elghazi, Lynda. "Développement du pancréas : rôle de ligands spécifiques de récepteurs à activité tyrosine kinase." Paris 7, 2002. http://www.theses.fr/2002PA077074.

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11

Duplaquet, Leslie. "Implication du récepteur à activité tyrosine kinase (RTK) MET sur la balance survie/apoptose et identification de nouvelles mutations de RTKs dans les cancers colorectaux métastatiques." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S031/document.

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Les RTKs sont impliqués dans le dialogue au sein des tissus par la régulation de nombreuses réponses cellulaires dont la survie, la prolifération ou la mobilité. Dans les cancers, ces récepteurs sont fréquemment dérégulés notamment par des mutations activatrices. Ainsi, la suractivation des RTKs induit la transformation cellulaire et la tumorigenèse en favorisant par exemple la survie cellulaire. Depuis le début des années 2000, le développement de molécules inhibitrices de l’activité tyrosine kinase (TKI) et d’anticorps bloquant l’interaction ligand/récepteur ont montré que les RTKs représent

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12

Dikic, Inga. "Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5316-3/.

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13

Grockowiak, Élodie. "Role of the Bone Morphogenetic Proteins pathway in tyrosine kinase inhibitors resistance in Chronic Myeloid Leukemia." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1253.

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La leucémie Myéloïde Chronique est un néoplasme myéloprolifératif causé par l'expression de la kinase oncogène BCR-ABL. Les Inhibiteurs de Tyrosine Kinase (ITK) spécifiques de BCR-ABL ont révolutionné la prise en charge de la maladie. Les ITK ne sont cependant pas curatifs ; en effet, certaines cellules souches leucémiques (CSL) sont résistantes aux ITK, et persistent dans la moelle osseuse des patients même en rémission prolongée. Ces CSL sont probablement responsables de la rechute chez 60% de ces patients après arrêt des ITK. 30% des patients développent une résistance aux ITK via des mécan

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14

Zhao, Tong Tong. "Mechanism and Therapeutic Potential of Statin-Mediated Inhibition of Tyrosine Kinase Receptors." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20334.

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Receptor tyrosine kinases (RTK) are key regulators of growth, differentiation and survival of epithelial cells and play a significant role in the development and progression of cancers derived from these tissues. In malignant cells, these receptors and their downstream signalling pathways are often deregulated, leading to cell hyper-proliferation, enhanced cell survival and increased metastatic potential. Furthermore, endothelial expressed RTKs regulate tumor angiogenesis allowing for tumor growth and maintenance by promoting their vascularization. Epithelial malignancies such as squamous cell

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15

Ringuette, Randy. "The Role of Signaling Pathway Integration in Neurogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35108.

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Proper central nervous system development is critical for survival and depends on complex intracellular and extracellular signaling to regulate neural progenitor cell growth and differentiation; however, the mechanisms that mediate molecular crosstalk between pathways during neurogenesis are not fully understood. Here, we explored the integration of the Hedgehog (Hh) signaling pathway with the two critical developmental pathways, Receptor Tyrosine Kinase (RTK) and Notch signaling, in the growth and maintenance of neural progenitors in the developing neuroretina. We found combined and sustain

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Shen, Ying. "Regulation of EphA4 expression through the APC-mediated ubiquitin-proteasome pathway /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20SHEN.

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17

Claas, Allison. "Systems modeling of quantitative kinetic data identifies receptor tyrosine kinase-specific resistance mechanisms to MAPK pathway inhibition in cancer." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112514.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 149-156).<br>Targeted cancer therapeutics have seen constraint in clinical efficacy due to resistance. Indicators for resistance may include genetic mutations or protein-level overexpression of targeted or bypass receptor tyrosine kinases (RTKs). While the latter is often attributed to gene amplification, genetic characterization of tumor biopsies has failed to explain substantial proportions of resistance. We

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18

Paliouras, Grigorios Nikiforos. "Effect of ethanol on the Jak-Stat pathway : is this an NMDA mediated event?" Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79062.

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Alcohol affects many neurochemical processes, causing long-lasting changes in both the adult and developing brain. The Jak-Stat transcriptional activation pathway plays a role in the control of neuronal proliferation, survival and differentiation, but the effects of ethanol on the system have not been fully elucidated. The goal of this project was to define the effects of acute and subchronic ethanol exposure on the expression of proteins in the Jak-Stat pathway, using cultured NG108-15 cells, and in addition, to test the hypothesis that these effects are mediated through the NMDA recep

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19

Fraser, Lindsay. "Role of the SCF/KIT signalling pathway in embryonic stem cells." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5564.

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Murine embryonic stem (ES) cells are derived from the inner cell mass of the developing embryonic blastocyst. These cells can self renew which allows them to be propagated indefinitely in the laboratory and they can differentiate into cell types derived from all three germ layers. Manipulation of the mouse genome using gene targeting techniques in conjunction with ES cell technology has provided valuable insights into embryonic development and cell lineage specification. KIT is a trans-membrane receptor tyrosine kinase (RTK) that dimerises upon binding to its ligand, stem cell factor (SCF) res

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20

Mukhtar, Lenah. "Targeting the Mevalonate Pathway Enhances the Efficacy of Epidermal Growth Factor Receptor – Tyrosine Kinase Inhibitors in Head and Neck Squamous Cell Carcinoma." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40391.

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Epidermal growth factor receptor (EGFR) is highly expressed in head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC) and is a key regulator of tumor cell growth and survival. Erlotinib, also known as tarceva, (a first-generation) and afatinib, also known as giotrif, (a second-generation) are tyrosine kinase inhibitors (TKIs) of EGFR. These TKIs are recognized therapeutic agents in these tumor types, as they inhibit EGFR signaling but show limited activity as single agents. Novel strategies will likely require EGFR-TKIs combination with an agent(s) that will enhan

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Sinha, Tanay Kumar. "Validation and optimization of multiplexInSitu PLA for signalling pathway analysis." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450392.

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With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. This project validates and optimizes a new method of In situ PLA that incorporates the usage of different padlocks and template oligos. Multiple

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22

Singh, Rajeev [Verfasser], and Matthias [Akademischer Betreuer] Lauth. "Elucidating the functional role of Dual-specificity Tyrosine Regulated Kinase 1B (DYRK1B) in the Hedgehog (Hh) Signaling Pathway. / Rajeev Singh ; Betreuer: Matthias Lauth." Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/1166314146/34.

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23

Qi, Wenqing, Larry Cooke, Amy Stejskal, et al. "MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer." BioMed Central, 2009. http://hdl.handle.net/10150/610342.

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BACKGROUND:Prostate cancer is a common disease in men and at present there is no effective therapy available due to its recurrence despite androgen deprivation therapy. The epidermal growth factor receptor family (EGFR/HER1, HER2/neu and HER3)/PI3K/Akt signaling axis has been implicated in prostate cancer development and progression. However, Erlotinib, an EGFR tyrosine kinase inhibitor, has less effect on proliferation and apoptosis in prostate cancer cell lines. In this study, we evaluate whether MP470, a novel receptor tyrosine kinase inhibitor alone or in combination with Erlotinib has inh

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24

Bailey, Kelly M. "Focal adhesion kinase mediates caveolin-1 expression during epithelial to mesenchymal transition a novel pathway regulating aspects of cell motility in cancer /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5804.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains x, 229 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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25

Muhlrad, Paul, Jessica Clark, Ubaydah Nasri, Nicholas Sullivan, and Craig LaMunyon. "SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans." BioMed Central, 2014. http://hdl.handle.net/10150/610393.

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BACKGROUND:The SPE-8 group gene products transduce the signal for spermatid activation initiated by extracellular zinc in C. elegans. Mutations in the spe-8 group genes result in hermaphrodite-derived spermatids that cannot activate to crawling spermatozoa, although spermatids from mutant males activate through a pathway induced by extracellular TRY-5 protease present in male seminal fluid.RESULTS:Here, we identify SPE-8 as a member of a large family of sperm-expressed non-receptor-like protein-tyrosine kinases. A rescuing SPE-8::GFP translational fusion reporter localizes to the plasma membra

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26

Eimer, Sandrine. "Etude des réponses induites par l’erlotinib dans des cellules de lignées de glioblastome." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21822/document.

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Le glioblastome (GBM), tumeur de plus haut grade du système nerveux central (OMS grade 4) a un pronostic très sombre, quelque soit le traitement, lié à une résistance à l’apoptose. L’erlotinib (Tarceva®, OSI 774) est un inhibiteur de la tyrosine kinase du récepteur au facteur de croissance épithélial (EGFR). L’hyper-expression et l’amplification du gène de l’EGFR dans 40 à 60% des GBM, fourni un rationnel pour utiliser l’erlotinib. Nous avons montré sur U87-MG et DBTRG-05MG, deux lignées de GBM, l’absence d’apoptose avec l’erlotinib, liée soit à un déficit en pro-caspase 3, soit à une accumula

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27

Guidi, Mònica. "Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7114.

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Neurotrophins and their receptors are key molecules in the development of the<br/>nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor<br/>NTRK3, which exists in two major isoforms in humans, the full-length kinaseactive<br/>form (150 kDa) and a truncated non-catalytic form (50 kDa). The two<br/>variants show different 3'UTR regions, indicating that they might be differentially<br/>regulated at the post-transcriptional level. In this work we explore how<br/>microRNAs take part in the regulation of full-length and truncated NTRK3,<br/>demonstrating that the two isof

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28

Zahr, Stephanie. "GGTI-298 in Combination with EGFR Inhibitors: Evaluating a Novel Therapy in Head and Neck Squamous Cell Carcinomas." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/25488.

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Overall survival of the metastatic forms of epithelial derived cancers, especially head and neck squamous cell carcinomas (HNSCC), has not significantly improved even with the application of aggressive combined modality approaches incorporating radiation and chemotherapy. Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in HNSCC. We have previously demonstrated that the combination of lovastatin, a potent inhibitor of the mevalonate pathway, with EGFR tyrosine kinase inhibitors induced robust synergistic cytotoxicity. However, the us

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Basbous, Sara. "La voie Rho/ROCK, un nouveau mécanisme d'échappement des cellules leucémiques au contrôle de l'immunité T innée." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT1402/document.

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Les cellules iNKT et T CDS innées sont présumées contribuer à l'irnmunosurveillance (IS) des cancers et sont fonctionnellement déficientes dans la leucémie myéloïde chronique (LMC). Notre hypothèse était que ces défauts résultent de l'incapacité des cellules dendritiques myéloïdes (mDC) à les activer. Des analyses par cytométrie en flux et microscopie confocale ont révélé une baisse de l'expression membranaire de CD 1 d, qui présente les antigènes aux cellules iNKT, à la surface des mDC des patients LMC, par comparaison aux sujets sains. Ce défaut n'est associé ni à un défaut de maturation des

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30

Catozzi, Simona. "Rétroactivité dans la transduction du signal : étude comparative des réponses en aval et en amont dans les cascades de signalisation." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4122/document.

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Les cellules communiquent avec leur environnement par l’intermédiaire d’un réseau de transduction du signal, leur permettant d’interpréter des signaux physico-chimiques et de produire des réponses appropriées. Ce mécanisme est orchestré par des cascades de signalisation, qui jouent le rôle d’émetteurs intracellulaires en transférant des stimuli biochimiques entre la membrane et le noyau. Il a été montré qu’une perturbation peut se propager en amont (et pas seulement en aval) d’une cascade par un phénomène appelé rétroactivité. Notre étude vise à comparer les conditions biochimiques qui favoris

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31

Soumya, A. M. "Genetics of Glioma : Transcriptome and MiRNome Based Approches." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3305.

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Glioma, the tumor of glial cells, is one of the common types of primary central nervous system (CNS) neoplasms. Astrocytoma is the most common of all gliomas and originates from astrocytic glial cells. Astrocytoma tumors belong to two main categories: benign tumors, comprising of grade I Pilocytic astrocytoma and malignant tumors which diffusely infiltrate throughout the brain parenchyma. Diffusely infiltrating astrocytomas are graded into diffuse astrocytoma (DA; grade II), anaplastic astrocytoma (AA; grade III) and glioblastoma (GBM; grade IV) in the order of increasing malignancy. Patie

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Soumya, A. M. "Genetics of Glioma : Transcriptome and MiRNome Based Approches." Thesis, 2013. http://etd.iisc.ernet.in/2005/3305.

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Glioma, the tumor of glial cells, is one of the common types of primary central nervous system (CNS) neoplasms. Astrocytoma is the most common of all gliomas and originates from astrocytic glial cells. Astrocytoma tumors belong to two main categories: benign tumors, comprising of grade I Pilocytic astrocytoma and malignant tumors which diffusely infiltrate throughout the brain parenchyma. Diffusely infiltrating astrocytomas are graded into diffuse astrocytoma (DA; grade II), anaplastic astrocytoma (AA; grade III) and glioblastoma (GBM; grade IV) in the order of increasing malignancy. Patie

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33

Sanchez, Melanie. "Growth factor activation of ErbB2/ErbB3 signaling pathways regulate the activity of Estrogen Receptors (ER)." Thèse, 2010. http://hdl.handle.net/1866/4472.

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La signalisation par l’estrogène a longtemps été considérée comme jouant un rôle critique dans le développement et la progression des cancers hormono-dépendants tel que le cancer du sein. Deux tiers des cancers du sein expriment le récepteur des estrogènes (ER) qui constitue un élément indiscutable dans cette pathologie. L’acquisition d’une résistance endocrinienne est cependant un obstacle majeur au traitement de cette forme de cancer. L’émergence de cancers hormono-indépendants peut est produite par l’activation de ER en absence d’estrogène, l’hypersensibilité du récepteur aux faibles concen

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Nawaz, Zahid. "Epigenetic Modulators of Glioma : From miRNAs to Chromatin Modifiers." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3146.

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The glial cells of the brain and the peripheral nervous system retain the capacity to divide and proliferate throughout the lifespan of an individual and thereby have the propensity to give rise to the most adult neurological tumours. Among them, the tumours which arise from different kinds of glial cells are referred to as gliomas. Of the various types of gliomas, astrocytomas are the most common central nervous system neoplasms which make upto 60% of all the primary brain tumours. Being the most prevalent type, the WHO classifies them into grades ranging from I to IV based on their intensity

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Nawaz, Zahid. "Epigenetic Modulators of Glioma : From miRNAs to Chromatin Modifiers." Thesis, 2016. http://hdl.handle.net/2005/3146.

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The glial cells of the brain and the peripheral nervous system retain the capacity to divide and proliferate throughout the lifespan of an individual and thereby have the propensity to give rise to the most adult neurological tumours. Among them, the tumours which arise from different kinds of glial cells are referred to as gliomas. Of the various types of gliomas, astrocytomas are the most common central nervous system neoplasms which make upto 60% of all the primary brain tumours. Being the most prevalent type, the WHO classifies them into grades ranging from I to IV based on their intensity

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Nasrazadani, Azadeh. "The role of JNK2 and JNK1 in breast cancer mediated invasion and metastasis." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-08-1576.

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Receptor tyrosine kinase (RTK) inhibitors are emerging as an effective therapeutic option for treatment of breast cancer patients overexpressing particular RTKs. However, more patients may benefit from an inhibitor targeting a common effector protein downstream several RTKs. The presented studies herein identify c-Jun N-Terminal Kinase 2 (JNK2), a kinase downstream multiple RTKs, as a novel target to effectively inhibit Phosphatidylinositol 3-kinase/AKT activation and metastasis. Knockdown of JNK2 in the highly metastatic 4T1.2 mammary cancer cells significantly decreased growth factor induce

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Poliszczuk, Peter. "The Search for Novel Wnt Pathway Modulators." Thesis, 2010. http://hdl.handle.net/1807/25895.

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Signaling pathways are complex and function to transmit signals from the extracellular environment into the cell. Analysis of results obtained from a high throughput siRNA screen led to the identification of Membrane protein palmitoylated 3 (MPP3) and Leukocyte Tyrosine Kinase (LTK) as novel negative regulators of the Wnt pathway. MPP3 is a MAGUK family protein and domain mapping studies indicated that the Guk domain plays a role in the negative regulation of the pathway. LTK, a receptor tyrosine kinase, has several transcript variants one of which lacks the entire kinase domain (LTK∆KD).

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38

Zhang, Xin. "Synthesis of Furo[2,3-d]Pyrimidines, Thieno[2,3-d]Pyrimidines, Pyrrolo[2,3-d]Pyrimidines as Classical and Nonclassical Antifolates, Receptor Tyrosine Kinase (RTK) Inhibitors and Antimitotic Agents." 2012. http://digital.library.duq.edu/u?/etd,154127.

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An introduction, background and research progress in the areas of antifolates, receptor tyrosine kinase (RTK) inhbitors and antimitotic agents has been discussed. <br>Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of infectious diseases. Classical antifolates, in most cases, are substrates for folypoly-g-glutamate synthase (FPGS) and rely on folate transporter systems to enter cells. As a part of this study, twenty-eigh

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Chen, Yu-Yun, and 陳玉芸. "Studies of tyrosine kinase signal pathway in enterovirus 71-infected host cell using proteomic approach." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/54173787966789860857.

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碩士<br>長庚大學<br>基礎醫學研究所<br>91<br>Enterovirus 71 is enterovirus of the family Picornaviridae. In 1998, an enterovirus 71 epidemic in Taiwan was associated with hand, foot, and mouth disease (HFMD)/herpangina. However, the role of intracellular signaling pathways in enterovirus 71-mediated pathogenesis was unclear. Previous studies show that tyrosine phosphorylation events appeared to be controlled by virus infection. In this study we observed that two proteins of 45 and 150 kDa enhanced tyrosine phosphorylation 1 h p.i. We further demonstrated that the 45 kDa protein may be ERK1/2. The ERK1/2 reg

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Subramanian, Aparna. "The BMP4 stress erythroid pathway and the Kit receptor tyrosine kinase in Friend virus induced erythroleukemia." 2005. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-963/index.html.

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41

MOHAMED, AHMED. "Identification of Genes Involved in the C. elegans VAB-1 Eph Receptor Tyrosine Kinase Signaling Pathway." Thesis, 2011. http://hdl.handle.net/1974/6615.

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The generation of a functional nervous system requires that neuronal cells and axons navigate precisely to their appropriate targets. The Eph Receptor Tyrosine Kinases (RTKs) and their ephrin ligands have emerged as one of the important guidance cues for neuronal and axon navigation. However, the molecular mechanisms of how Eph RTKs regulate these processes are still incomplete. The purpose of this work was to contribute to the understanding of how Eph receptors regulate axon guidance by identifying and characterizing components of the Caenorhabditis elegans Eph RTK (VAB-1) signaling pathway.

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42

Villait, Akash. "The role of the spleen tyrosine kinase in activating the MTORC1 pathway in pancreatic cancer cell lines." Thesis, 2020. https://hdl.handle.net/2144/41168.

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With a five-year survival rate of less than 5%, pancreatic cancer is one of the deadliest cancers. The most common activating mutations in pancreatic cancer are found in the KRAS gene, causing a constitutively-active KRAS protein in approximately 90% of pancreatic ductal adenocarcinomas (PDAC). PDAC-derived cell lines that harbor oncogenic KRAS mutations can be divided into two classes, KRAS dependent (or addicted) cells and KRAS independent cells. Oncogene dependency (or addiction) is a phenomenon where tu-mors require sustained activity of a single aberrantly activated gene despite the accum

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Jain, Ruchi. "Spatio-temporal Regulation of GPCR mediated MAPK Transactivation in Living Cells." Thesis, 2015. https://etd.iisc.ac.in/handle/2005/4817.

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Signal transduction is a mode of cellular communication essential for an organism’s sustenance and survival. Cell communication in higher organisms is largely executed by two classes of cell surface receptors i.e. G-protein coupled Receptors (GPCRs) and receptor tyrosine kinases (RTKs). Though the activation of each of these receptors have shown to regulate cellular responses through a linear pathway the underlying signaling events are much more complicated. A number of studies have shown that the signaling regulators of the RTK mediated pathway can be cross-activated by GPCRs activation

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Chang, Ya-Jen, та 張雅貞. "Interferon-γ Induced Intercellular Adhesion Molecule-1 Expression in Human Alveolar Epithelial Cells: Involvement of PKC-dependent Activation of c-Src Tyrosine Kinase Pathway". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/13174799804755667916.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>89<br>IFN-g induced ICAM-1 expression in human NCI-H292 epithelial cells, as shown by ELISA and immunofluorescence staining. The enhanced ICAM-1 expression resulted in increased adhesion of U937 cells to NCI-H292 cells. A PI-PLC inhibitor (U73122), tyrosine kinase inhibitors (genistein or herbimycin), or Src family inhibitor (PP2) attenuated the IFN-g-induced ICAM-1 expression. PKC inhibitors (staurosporine or Ro 31-8220) also inhibited IFN-g-induced response. TPA, a PKC activator, stimulated ICAM-1 expression, this effect being inhibited by tyrosine kinase or Src in

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"Regulation of PDGF receptor trafficking and signalling by the RabGAP function of p85α". Thesis, 2014. http://hdl.handle.net/10388/ETD-2014-07-1655.

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Activated receptor tyrosine kinases recruit many signalling proteins to initiate downstream cell proliferation and survival pathways, including phosphatidylinositol 3-kinase (PI3K), a heterodimer consisting of a p85 regulatory protein and a p110 catalytic protein. Our laboratory has previously shown the p85α protein also has in vitro GTPase activating protein (GAP) activity towards Rab5 and Rab4, small GTPases that regulate vesicle trafficking events for activated receptors. Expression of a p85α protein containing an arginine to alanine substitution at position 274 (p85R274A) that affects its

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Heller, Daniela [Verfasser]. "Auffinden von Inhibitoren der tRNA-Guanin-Transglykosylase (TGT) und der insulin-like growth factor 1 receptor tyrosine kinase (IGF-1-RTK) aus Pflanzenextrakten durch Ligandenfischen sowie deren Isolierung und Identifizierung / vorgelegt von Daniela Heller." 2006. http://d-nb.info/982576625/34.

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Lisboa, Rafael Jorge Fernandes. "Cancro oral e terapias alvo." Master's thesis, 2018. http://hdl.handle.net/10284/7411.

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O cancro oral é definido pela Classificação Internacional de Doenças pelo conjunto de tumores malignos que afetam qualquer localização da cavidade oral, dos lábios à garganta, incluindo as amígdalas e a faringe. É importante referir que o cancro oral é um dos tipos de doença oncológica mais comum a nível mundial e apresenta uma elevada taxa de mortalidade. De uma forma genérica, esta doença tem como principais abordagens terapêuticas a intervenção cirúrgica, a radioterapia e a quimioterapia, ou até mesmo a combinação destas terapias. Esta dissertação tem como base expor e compreender de

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