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Dissertations / Theses on the topic 'Tyrosine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Iron, Albert. "L'acide DL-amino-1-(parahydroxyphényl)-2-éthylphosphonique, analogue phosphonique de la tyrosine : quelques propriétés physicochimiques et métaboliques." Bordeaux 2, 1989. http://www.theses.fr/1989BOR2E001.

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2

Nadeau, Robert J. "Sprouty Regulation of Tyrosine Kinase Signal Transduction is Governed by Tyrosine Phosphorylation: A Functional Role for Sprouty2 N- and C- Terminal Tyrosines." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/NadeauRJ2006.pdf.

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3

Lee, Joseph Moon-Hee 1967. "Characterization of tyrosine phosphorylation in the protein tyrosine phosphatase CD45." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37758.

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The enzymatic activity of the protein tyrosine phosphatase, CD45 has been demonstrated to play an absolutely required role in the regulation of Src family protein tyrosine kinases in T lymphocytes. CD45 function during early events of antigen receptor signaling has been well established, however, the role of CD45 during later stages of T cell activation is only beginning to emerge. Transient tyrosine phosphorylation of CD45 has previously been demonstrated. We show this phosphorylation can be sustained through treatment of a T cell hybridoma cell line with the PTPase inhibitor, pervanadate. Ty

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4

Lu, Wei. "Regulation of protein tyrosine phosphatase SHP-2 by tyrosine phosphorylation." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3080719.

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5

Chen, Shirley Chun-Jyue. "The regulation and function of protein tyrosine phosphatase alpha (PTPα) tyrosine phosphorylation". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31583.

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Protein tyrosine phosphatase alpha (PTPα) is a ubiquitously expressed receptor protein tyrosine phosphatase that functions as an early upstream regulator in the integrin signaling pathway. The integrins, by interacting with extracellular matrix components, regulate cell growth, migration, and survival, and are functionally linked to multiple aspects of cancer biology such as invasion and metastasis. PTPα plays a major role in the integrin signaling cascade by activating Src family kinases (SFKs), which are required for the full activation of the central signaling molecule focal adhesion kinase

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6

Hardwick, James S. "Regulation of the Lck tyrosine protein kinase by oxidant-induced tyrosine phosphorylation /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9814544.

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7

Fustier, Caroline. "Tyrosinase nanocapsules for the lowering of systemic tyrosine for the treatment of melanoma." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18429.

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This study describes the preparation and characterization of biodegradable nano-artificial cells containing the enzyme tyrosinase. The rationale for doing this is that this may have potential implication for the treatment of melanoma, a fatal skin tumour that is tyrosine-dependent. A poly (ethylene glycol)- poly (lactic acid) block-copolymer has been prepared and characterized. A method for the preparation of the tyrosinase nanocapsules has been designed. The physical properties and the membrane properties of the nanocapsules have been characterized. The electron microscopy images show round a

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8

Sun, Guobin. "The role of protein tyrosine phosphatase alpha tyrosine 789 phosphorylation in integrin signaling." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43924.

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Focal adhesions (FA) form interfaces between the extracellular matrix and the cytoskeleton to regulate cell responses such as cell proliferation, survival, and migration. The functions and dynamic interactions of many of the ~180 molecules in this integrin-initiated FA complex network are far from fully understood. Among these is the receptor-like protein tyrosine phosphatase PTPα. In addition to the integrin-proximal action of PTPα to catalyze activation of Src family kinases, subsequent phosphorylation of PTPα at its C-terminal Tyr789 site is essential and acts in an unknown manner to promot

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9

Mehere, Prajwalini V. "Towards the Characterization of Enzymes Involved in the Metabolism of Tyrosine and Tyrosine Derivatives." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77289.

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Tyrosine is involved in many biological processes including protein synthesis. This dissertation is focused on two different aspects: tyrosine catabolism and tyrosine derivative metabolism. Tyrosine undergoes degradation via tyrosine aminotransferase (TAT). Deficiency of TAT leads to some disease conditions or tyrosinemia type II. TAT has been characterized in several species, including humans. Mouse tyrosine aminotransferase was used as a model protein for the tyrosine catabolism portion of this study. Characterization of TAT included its expression in a bacterial expression system, purificat

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10

Veenstra, Cynthia. "The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-135047.

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Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. Luminal breast cancers are characterised by the expression of oestrogen receptor and generally have a good prognosis. More aggressive tumours are marked by the presence of growth stimulating receptor tyrosine kinase HER2 (HER2-like breast cancer) or the absence of oestrogen receptor, progesterone receptor, and HER2 (triple-negative breast cancer,TNBC

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11

Grangeasse, Christophe. "Phosphorylation des protéines bactériennes au niveau de la tyrosine : étude des activités protéine-tyrosine kinase et phosphotyrosine-protéine phosphatase chez Acinetobacter johnsonii." Lyon 1, 1998. http://www.theses.fr/1998LYO10061.

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Nous avons demontre l'existence d'une modification post-traductionnelle des proteines par phosphorylation chez la bacterie acinetobacter johnsonii. Cette modification concerne principalement une proteine de 82 kilodaltons, localisee dans la membrane interne de la cellule bacterienne, que nous avons purifiee a homogeneite. Nous avons montre que cette proteine, appelee ptk pour prokaryotic protein-tyrosine kinase, est capable de s'autophosphoryler au niveau de plusieurs residus de tyrosine. Le gene correspondant, ptk, a ete clone et totalement sequence. L'analyse theorique de la sequence de la p

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12

Ripani, Meri <1977&gt. "p300/CBP tyrosine phosphorylation in response to dna damage activated by c-Abl tyrosine kinase." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2276/1/Ripani_Meri_tesi.pdf.

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The nuclear signaling that is triggered in response to DNA damage entails the recruitment and assembly of repair proteins and the induction of genes involved in the activation of cell cycle checkpoint, apoptosis or senescence. The extensive changes in chromatin structure underlying these processes suggest that chromatin-modifying enzymes could be relevant targets of DNA damage-activated signaling. The acetyltransferases p300 and CBP participate in DNA damage-activated responses, including local histone hyperacetylation, cell cycle regulation, and co-activation of DNA damage activated proteins,

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13

Ripani, Meri <1977&gt. "p300/CBP tyrosine phosphorylation in response to dna damage activated by c-Abl tyrosine kinase." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2276/.

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The nuclear signaling that is triggered in response to DNA damage entails the recruitment and assembly of repair proteins and the induction of genes involved in the activation of cell cycle checkpoint, apoptosis or senescence. The extensive changes in chromatin structure underlying these processes suggest that chromatin-modifying enzymes could be relevant targets of DNA damage-activated signaling. The acetyltransferases p300 and CBP participate in DNA damage-activated responses, including local histone hyperacetylation, cell cycle regulation, and co-activation of DNA damage activated proteins,

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14

Yu, Binglan 1971. "Polyhemoglobin-tyrosinase and artificial cells microencapsulated tyrosinase for the removal of systemic tyrosine : a potential novel therapy for melanoma." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38534.

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Artificial cells microencapsulation have a number of potential areas of application. Studies showed that lowering of tyrosine level could inhibit the growth of melanoma. However, at present there is no practical method to lower the tyrosine level in humans. We have therefore devised novel methods as follows. (1) Microencapsulation of tyrosinase for the removal of systemic tyrosine by oral administration. Characterization, optimization, and feasibility studies were carried out to test the therapeutic potentials. In temperature and pH studies, the encapsulated tyrosinase maintained higher enzyme

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15

Robertson, Sears Heather C. 1975. "The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32254.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.<br>Includes bibliographical references.<br>Cell migration and axon guidance are highly similar processes important for the development of the nervous system. Both processes involve the transduction of signals across the membrane, resulting in changes in the cytoskeleton. I have examined the roles of two receptors that are involved in axon guidance and cell migration in Drosophila. Ptp69D is a receptor tyrosine phosphatase required for axon guidance in the developing embryo and for layer-specific axon targeting in t

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16

Lebel, France. "Évaluation de trois tests de dépistage de porteurs et recherche d'un effet fondateur dans la tyrosinemie héréditaire de type 1 au Saguenay-Lac-St-Jean /." Thèse, Québec : Université Laval, 1992. http://theses.uqac.ca.

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Mémoire (M.Sc.)-- Université du Québec à Chicoutimi, 1992.<br>Ce mémoire a été réalisé à l'UQAC dans le cadre du programme de maîtrise en médecine expérimentale (génétique) extensionné de l'Université Laval à l'UQAC. CaQCU Bibliogr.: f. [1-5]. Document électronique également accessible en format PDF. CaQCU

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17

Inamdar, Vaishali Vijay. "FUNCTIONAL PROTEIN TYROSINE PHOSPHATASES IN PLATELETS." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/473257.

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Biomedical Sciences<br>Ph.D.<br>Platelets are small anucleate cells in blood that are derived from megakaryocytes and their primary function is to prevent bleeding. Upon vascular injury, the sub-endothelial collagen gets exposed to which platelets bind and aggregate eventually forming a platelet plug. There are several receptors on platelet surface that can be divided into two broad categories; the immune-receptor tyrosine-based activation motif (ITAM) and the G protein-coupled receptors (GPCRs). The role of several protein tyrosine kinases (PTKs) downstream of ITAM and GPCRs has been extensiv

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18

Melhado, Ian Granville. "Characterization of protein-tyrosine-phosphatase E." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/NQ46390.pdf.

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19

Bäckesjö, Carl-Magnus. "Molecular biology of Bruton's tyrosine kinase /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-693-6.

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20

Mertins, Philipp. "Investigations of protein tyrosine phosphatase functions." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/631437/631437.pdf.

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21

Pannifer, Andrew. "Structural studies on protein tyrosine phosphatases." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390536.

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22

Page, Timothy C. M. "Mechanism based inhibitors of tyrosine kinases." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260163.

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23

Iqbal, Azhar. "Towards understanding the photochemistry of tyrosine." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/3735/.

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The H-atom detachment driven through the 1πσ* states of biological chromophores containing an X-H bond (where X = N or O) upon UV absorption is ubiquitous in nature. Understanding the role of this dissociative state in the chromophores and their respective amino acids following UV excitation would enable a step change towards establishing a better understanding of the mechanisms of photostability of larger peptides in the gas-phase. The work presented in this thesis focuses on the H-atom elimination of phenol and indole, the chromophores of the amino acids tyrosine and tryptophan, respectively

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24

Gaspar, Hubert Baburaj. "Molecular studies on Bruton's tyrosine kinase." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322123.

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25

Cory, Giles Oliver Cholmondeley. "Molecular interactions of Bruton's tyrosine kinase." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264935.

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26

Sørum, Christopher. "Synthesis of new tyrosine kinase inhibitors." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kjemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-6863.

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27

Topall, Guy. "Etudes biochimiques et pharmacologiques de la tyrosine et d'agents affectant son métabolisme." Paris 5, 1988. http://www.theses.fr/1988PA05P612.

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28

Gervais, François G. "Regulation of lymphocyte-specific tyrosine protein kinase p56[superscript]l[superscript]c[superscript]k by tyrosine phosphorylation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0023/NQ29945.pdf.

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29

Hatahet, Laith. "Regulation of lymphocyte specific protein tyrosine kinase, Lck, by tyrosine phosphorylation : evaluation of the tail-bite model." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78375.

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Several studies show that the catalytic function of the Src-family protein kinase Lck is repressed by phosphorylation of a conserved carboxyl-terminal residue (Y505). This phosphorylation allows the molecule to bind to its SH2 domain rendering the protein in an inactive state, a proposed model called the tail-bite mechanism. However, previous findings demonstrated that the activity of Lck from several T cell lines lacking CD45, which is the phosphatase known to dephosphorylate Y505, was significantly elevated. Herein, we are evaluating the tail bite mechanism model by examining the majo

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30

Faure, Camille. "Régulation de la localisation et de l'activation de la tyrosine kinase Pyk2 (Proline-rich tyrosine kinase 2)." Paris 6, 2010. http://www.theses.fr/2009PA066736.

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Proline-rich tyrosine kinase 2 (Pyk2) est une tyrosine kinase non récépteur de 110-kDa deappartenant à la famille de focal adhesion kinase (FAK). Elle a été initialement caractérisée comme une enzyme cytoplasmique. Elle est, régulée par autophosphorylation (sur la tyrosine 402) en réponse à l’des augmentations de la concentration de Ca2+calcium libre cytosolique. L’autophosphorylation de Pyk2 est cruciale pour son activation puisqu’elle permet le recrutement des membres de la famille de Src, conduisant à l’ac’tivation de nombreuses voies de signalisation. Pyk2 existe sous deux isoformes produi

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31

Lynch, Deborah Frances. "The role of tyrosine, serine and threonine phosphorylation in the regulation of the insulin receptor tyrosine kinase activity." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282141.

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32

Ezumi, Yasuharu. "Differntial regulation of protein-tyrosine phosphatases by integrin α_β_3 through cytoskeletal reorganization and tyrosine phosphorylation in human platelets". Kyoto University, 1997. http://hdl.handle.net/2433/202159.

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33

Beslu, Nathalie. "Etude des interactions et de ses conséquences fonctionnelles, des substrats (PI3K, GRB2) du récepteur hématopoîétique à activité tyrosine kinase : flt3." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX22052.

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Le recepteur flt3 est un recepteur hematopoietique a activite tyrosine kinase de classe iii. L'interaction de ce type de recepteur avec leur ligand induit leur homodimerisation, et conduit a leur transphosphorylation sur les residus tyrosine. Ces residus une fois phosphoryles interagissent specifiquement avec les domaines sh2 de proteines cytoplasmiques, conduisant a la transduction du signal. Nous avons dans un premier temps, entrepris de muter ces residus tyrosine pour identifier les sites d'interaction de certains substrats avec flt3. Cela nous a permis de montrer que la sous-unite p#8#5 de

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34

Le-Tien, Hoang Kim. "Regulation of protein tyrosine phosphatases by glucose." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0023/MQ50436.pdf.

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35

Jones, P. F. "Cloning and expression of tyrosine kinase genes." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382626.

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36

Marshall, Stuart J. "GPIb-mediated tyrosine phosphorylation in human platelets." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275467.

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37

Boys, Sarah K. "Tyrosine derivatives and their anti-cancer applications." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6243.

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The incorporation of a propargyl group to a natural product target allows for a streamlined approach to the investigation of structure activity relationships (SARs) and target identification in forward chemical genetics programmes using a ‘click’-based approach. To this end, an efficient synthesis of O-propargylated tyrosine derivatives was designed, and these have been used in the construction of peptide motifs both (a) derived from phage display libraries and (b) found in natural products. The L-tyrosine derivative Y* (compound I, X=H, R=H) was incorporated into a peptide sequence, PTTIYY, w

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38

Cooper, Margaret S. "Anti-cancer peptides containing modified tyrosine residues." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246193.

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39

Lannigan, Alison Kerr. "Tyrosine kinase growth factors in gastric cancer." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394975.

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40

Achison, Marcus. "Collagen-induced tyrosine phosphorylation in human platelets." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624884.

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41

Vavricka, Christopher John. "Mass Spectrometric Analysis of Tyrosine Metabolic Enzymes." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28585.

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The metabolism of tyrosine is essential for many critical biochemical events including catecholamine synthesis, melanogenesis and insect cuticle sclerotization. These pathways are highly regulated in both insects and mammals by many well-characterized enzymes including dopa decarboxylase and tyrosine hydroxylase. On the other hand, there are still many enzymes involved in these processes that we know very little about. Dopachrome tautomerase (DCT), dopachrome conversion enzyme (DCE) and α-methyldopa resistant protein (AMD) fall into the category of the less characterized enzymes. Dopachrome

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42

Zhai, Yujing. "Specificty and Inhibition of Protein Tyrosine Phosphatases." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429223068.

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43

Carvalho, Sara da Costa Cabral Pires. "Receptor Tyrosine Kinases interactions in human cancers." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/838.

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Mestrado em Biologia Molecular e Celular<br>Objectivos: Os receptores tirosina cinase MET, ErbB-2 e EGFR foram identificados como tendo um papel importante no desenvolvimento e progressão de cancro. O objectivo deste estudo foi determinar a expressão e procurar interacções dos receptores MET, ErbB-2 e EGFR em linhas celulares de carcinomas de tiróide e mama, e em tumores mamários. Métodos: Neste estudo a expressão e interacções dos receptores MET, ErbB-2 e EGFR foi determinada em duas linhas celulares de carcinoma da tiróide (TPC-1 e 8505C) e em duas linhas celulares de carcinomas da mama (MDA

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44

Halloran, Stephen Mitchell. "Regulation of tyrosine hydroxylase by protein phosphorylation /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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45

Kim, Yohan. "Tau associates with protein tyrosine phosphatase SHP2." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5535.

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The microtubule-associated protein tau normally functions to bind to and stabilize microtubules. However, evidence now indicates that tau may also play a critical role in signaling pathways linked to neuronal development and neurodegeneration. The tau association with numerous signaling proteins such as tyrosine kinases, adaptor proteins, and scaffold proteins support this hypothesis. Phospho-Y18 tau was previously found in Alzheimer’s disease (AD) brain. Interestingly, this phosphorylation appeared to be regulated during neurodegeneration possibly by a tyrosine phosphatase(s). Identifying a c

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46

Kuczek, Elizabeth Salome. "High-glycine/tyrosine keratin genes of wool." Title page, contents and summary only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phk95.pdf.

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47

BESTETTI, STEFANO. "AQP8, a redoxtat controlling tyrosine kinase signalling." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/170789.

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AQP8-mediated H2O2 transport allows efficient amplification of tyrosine kinase signalling, therefore influencing pathways frequently dysregulated under tumour progression. Besides, control of H2O2 cell permeability impacts life-death cell decisions in response to stress. Despite the important consequences of AQP8 gating, the precise biochemical modification that inhibits H2O2 transport still remains to be identified. We show here that the mechanism of regulation implies sulphydration of AQP8. Addition of an exogenous H2S donor (NaHS) is sufficient to block H2O2 entry and dampen EGF receptor si

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48

Andersson, Jeanette. "Finns det något värde i att mäta Peptide tyrosine tyrosine, Glucose-dependent insulinotropic polypeptide och Oxyntomodulin postprandialt vid måltidsstudier?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-45009.

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Övervikt och fetma sprider sig likt en epidemi över världen. Omkring 1,9 miljarder vuxna varöverviktiga år 2014 och av dessa klassificerades 600 miljoner som feta. Forskning kring fetmas uppkomst och nya former av behandlingsalternativ pågår. En viktig faktor för uppkomst av övervikt är aptitreglering, där t.ex. Peptide tyrosine tyrosine (PYY), Oxyntomodulin (OXM) och Glucosedependent insulinotropic polypeptide (GIP) har betydelse. En litteraturstudie genomfördes där totalt nio originalartiklar från PubMed utvärderades. Syftet var att undersöka om det finns något värde i att mäta dessa hormon

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49

Franck, Dominic. "Radiofluorinated cyclobutyl group for increased metabolic stability using tyrosine derivatives as model system." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-99003.

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The metabolic stability of these tracers is, in addition to its affinity and selectivity, an important factor for a successful disease diagnosis. PET tracers and all other drugs are subject to biotransformation which can form metabolites as a part of the inactivation or detoxification process of the human body. These metabolites may result in a higher background which has a detrimental influence on the PET image quality or can even make imaging impossible. The aim of this work was to investigate whether [18F]fluorocyclobutyl rings can be introduced into biologically active small molecules to i

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50

Lermet, Anne. "Synthèse d'inhibiteurs de la protéine à activité tyrosine kinase c-kit de type sauvage et muté." Lyon 1, 2006. http://www.theses.fr/2006LYO10026.

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