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Journal articles on the topic 'U-kappa'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Imbert, Cyril, Tianling Jin, and Luis Silvestre. "Hölder gradient estimates for a class of singular or degenerate parabolic equations." Advances in Nonlinear Analysis 8, no. 1 (2017): 845–67. http://dx.doi.org/10.1515/anona-2016-0197.

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Abstract We prove interior Hölder estimates for the spatial gradients of the viscosity solutions to the singular or degenerate parabolic equation u_{t}=\lvert\nabla u\rvert^{\kappa}\operatorname{div}(\lvert\nabla u\rvert^{p-% 2}\nabla u), where {p\in(1,\infty)} and {\kappa\in(1-p,\infty)} . This includes the from {L^{\infty}} to {C^{1,\alpha}} regularity for parabolic p-Laplacian equations in both divergence form with {\kappa=0} , and non-divergence form with {\kappa=2-p} .

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McIntosh, T. K., S. Fernyak, I. Yamakami, and A. I. Faden. "Central and systemic kappa-opioid agonists exacerbate neurobehavioral response to brain injury in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 267, no. 3 (1994): R665—R672. http://dx.doi.org/10.1152/ajpregu.1994.267.3.r665.

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The endogenous opioid peptide dynorphin has been implicated in the pathophysiology of secondary tissue injury after central nervous system (CNS) trauma. The detrimental effects of dynorphin appear to be mediated through both opioid receptors (probably kappa-receptors) and nonopioid mechanisms. However, both kappa-opioid agonists and antagonists have been reported to improve outcome in models of CNS trauma. To attempt to clarify this controversy, we examined the effects of centrally or systemically administered kappa-opioid agonists on neurological recovery after experimental fluid-percussion b

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Du, Yihong, Changfeng Gui, Kelei Wang та Maolin Zhou. "Semi-waves with Λ-shaped free boundary for nonlinear Stefan problems: Existence". Proceedings of the American Mathematical Society 149, № 5 (2021): 2091–104. http://dx.doi.org/10.1090/proc/15346.

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We show that for a monostable, bistable or combustion type of nonlinear function f ( u ) f(u) , the Stefan problem \[ { a m p ; u t − Δ u = f ( u ) , u > 0 a m p ; a m p ; for x ∈ Ω ( t ) ⊂ R n + 1 , a m p ; u = 0 and u t = μ | ∇ x u | 2 a m p ; a m p ; for x ∈ ∂ Ω ( t ) , \left \{ \begin {aligned} &u_t-\Delta u=f(u),\; u>0 & &\text {for}~~x\in \Omega (t)\subset \mathbb {R}^{n+1},\\ & u=0~\text {and}~u_t=\mu |\nabla _x u|^2 && \text {for}~~x\in \partial \Omega (t), \end {aligned} \right . \] has a traveling wave solution whose free boundary is Λ \Lambda -shaped, a

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Libermann, T. A., and D. Baltimore. "Activation of interleukin-6 gene expression through the NF-kappa B transcription factor." Molecular and Cellular Biology 10, no. 5 (1990): 2327–34. http://dx.doi.org/10.1128/mcb.10.5.2327.

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The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and

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Libermann, T. A., and D. Baltimore. "Activation of interleukin-6 gene expression through the NF-kappa B transcription factor." Molecular and Cellular Biology 10, no. 5 (1990): 2327–34. http://dx.doi.org/10.1128/mcb.10.5.2327-2334.1990.

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The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and

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Hui, Chun Yin, та Krishna Kishore. "Torsion elements of order 𝑝2 in the Nottingham group". Journal of Group Theory 23, № 3 (2020): 489–502. http://dx.doi.org/10.1515/jgth-2019-0114.

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AbstractLet κ be a characteristic p finite field of q elements and {\mathfrak{N}_{\kappa}} the Nottingham group over κ. Lubin associated to every conjugacy class of torsion element of {\mathfrak{N}_{\kappa}} a type. We establish an upper bound {B(q;l,m)} on the number of conjugacy classes of order {p^{2}} torsion elements u of {\mathfrak{N}_{\kappa}} of type {\langle l,m\rangle}. In the case where {l<p}, the bound {B(q;l,m)} is the exact number of conjugacy classes. Moreover, we give a criterion on when u and {u^{n}} are conjugate.

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Zhao, Shikai, Jeremiah P. Freeman, Philip F. VonVoigtlander, Martin W. Smith, and Jacob Szmuszkovicz. "Phenalene analogs of the kappa opiate agonist, U-50,488." Bioorganic & Medicinal Chemistry Letters 3, no. 12 (1993): 2641–46. http://dx.doi.org/10.1016/s0960-894x(01)80733-2.

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D'Andrea, Stan V., Eric T. Michalson, Jeremiah P. Freeman, Connie G. Chidester, and Jacob Szmuszkovicz. "trans-3,4-Diaminopiperidines. Azacyclohexane congeners of .kappa. agonist U-50488." Journal of Organic Chemistry 56, no. 9 (1991): 3133–37. http://dx.doi.org/10.1021/jo00009a038.

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9

Banakh, Taras, Serhii Bardyla, and Oleg Gutik. "The Lawson number of a semitopological semilattice." Semigroup Forum 103, no. 1 (2021): 24–37. http://dx.doi.org/10.1007/s00233-021-10184-z.

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AbstractFor a Hausdorff topologized semilattice X its Lawson number$$\bar{\Lambda }(X)$$ Λ ¯ ( X ) is the smallest cardinal $$\kappa $$ κ such that for any distinct points $$x,y\in X$$ x , y ∈ X there exists a family $$\mathcal U$$ U of closed neighborhoods of x in X such that $$|\mathcal U|\le \kappa $$ | U | ≤ κ and $$\bigcap \mathcal U$$ ⋂ U is a subsemilattice of X that does not contain y. It follows that $$\bar{\Lambda }(X)\le \bar{\psi }(X)$$ Λ ¯ ( X ) ≤ ψ ¯ ( X ) , where $$\bar{\psi }(X)$$ ψ ¯ ( X ) is the smallest cardinal $$\kappa $$ κ such that for any point $$x\in X$$ x ∈ X there ex

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10

Kavallaris, N. I. "ASYMPTOTIC BEHAVIOUR AND BLOW-UP FOR A NONLINEAR DIFFUSION PROBLEM WITH A NON-LOCAL SOURCE TERM." Proceedings of the Edinburgh Mathematical Society 47, no. 2 (2004): 375–95. http://dx.doi.org/10.1017/s0013091503000658.

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AbstractIn this work, the behaviour of solutions for the Dirichlet problem of the non-local equation$$ u_t=\varDelta(\kappa(u))+\frac{\lambda f(u)}{(\int_{\varOmega}f(u)\,\mathrm{d}x)^p},\quad \varOmega\subset\mathbb{R}^N,\quad N=1,2, $$is studied, mainly for the case where $f(s)=\mathrm{e}^{\kappa(s)}$. More precisely, the interplay of exponent $p$ of the non-local term and spatial dimension $N$ is investigated with regard to the existence and non-existence of solutions of the associated steady-state problem as well as the global existence and finite-time blow-up of the time-dependent solutio

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11

Sheng, J. Z., N. S. Wong, H. X. Wang, and T. M. Wong. "Pertussis toxin, but not tyrosine kinase inhibitors, abolishes effects of U-50488H on [Ca2+]i in myocytes." American Journal of Physiology-Cell Physiology 272, no. 2 (1997): C560—C564. http://dx.doi.org/10.1152/ajpcell.1997.272.2.c560.

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The effects of 10(-5) M trans-3,4-dichloro-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeacetamidel (U-50488H), a kappa-opioid receptor agonist, on cytosolic Ca2+ concentration ([Ca2+]i) and the [Ca2+]i transient in quiescent and electrically stimulated rat ventricular myocytes, respectively, were determined after the cells had been pretreated with pertussis toxin (PTX) or a tyrosine kinase inhibitor (genistein or tyrphostin). The [Ca2+]i was determined with a spectrofluorometric method, with fura 2 as Ca2+ indicator. U-50488H at 10(-5) M itself induced a [Ca2+]i transient in the quiescent cells but in

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Das, K. C., Y. Lewis-Molock, and C. W. White. "Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 269, no. 5 (1995): L588—L602. http://dx.doi.org/10.1152/ajplung.1995.269.5.l588.

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The effect of reducing agents, including N-acetylcysteine (NAC), dithiothreitol (DTT), and 2-mercaptoethanol (2-ME) on nuclear transcription factor-kappa B (NF-kappa B) activation and manganese superoxide dismutase (MnSOD) expression was investigated in a pulmonary adenocarcinoma (A549) cell line. NAC, DTT, and 2-ME each activated the transcription factor NF-kappa B and increased steady-state levels of MnSOD mRNA and enzyme activity in these cells. In addition, NAC, DTT, and 2-ME increased chloramphenicol acetyltransferase (CAT) activity in cells transfected with a construct containing the CAT

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13

Ventura, C., M. C. Capogrossi, H. A. Spurgeon, and E. G. Lakatta. "Kappa-opioid peptide receptor stimulation increases cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 5 (1991): H1671—H1674. http://dx.doi.org/10.1152/ajpheart.1991.261.5.h1671.

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Although kappa- and delta-opioid receptors on mammalian cardiac myocytes have been discovered recently, the intracellular effects that result from stimulation of these receptors remain unknown. We examine the effects of a rapid and brief exposure to a kappa-opioid receptor agonist on intracellular Ca2+, pH, and cell length in individual isolated rat ventricular cells. The specific kappa-agonist trans-dl-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]- benzene-acetamide (U-50488H) (methane sulfonate salt) caused a transient increase in cytosolic pH (pHi) measured from the change in SNARF

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14

Zhang, L., Z. F. Gu, T. Pradhan, R. T. Jensen, and P. N. Maton. "Characterization of opioid receptors on smooth muscle cells from guinea pig stomach." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 3 (1992): G461—G469. http://dx.doi.org/10.1152/ajpgi.1992.262.3.g461.

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On the basis of opioid-stimulated contraction of dispersed gastric smooth muscle cells it has been suggested that these cells possess opioid receptors of three subtypes: kappa (kappa), mu (mu), and delta (delta). We have used selective peptidase-resistant radioligands, agonists and antagonists, to examine receptor subtypes on dispersed gastric smooth muscle cells from guinea pigs prepared by collagenase digestion. The kappa-agonist U-50488H, the mu-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAGO), and the delta-agonist [D-Pen2,Pen5]enkephalin (DPDPE) each caused muscle contraction. The conc

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15

Camacho Ochoa, M., G. D. Vogelsang, J. T. Lum, P. F. VonVoigtlander, and M. F. Piercey. "Effect of the anticonvulsant U-54494A on cortical neuron excitability: Comparison to the kappa agonist U-50488H." Life Sciences 50, no. 17 (1992): 1225–33. http://dx.doi.org/10.1016/0024-3205(92)90322-g.

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16

Binder, Waltraud, Halina Machelska, Shaaban Mousa та ін. "Analgesic and Antiinflammatory Effects of Two Novel κ-Opioid Peptides". Anesthesiology 94, № 6 (2001): 1034–44. http://dx.doi.org/10.1097/00000542-200106000-00018.

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Background This study investigates two new kappa-agonist tetrapeptides, FE 200665 and FE 200666, with high peripheral selectivity as a result of poor central nervous system penetration. Methods Four days after administration of Freund adjuvant into the hind paw of male Wistar rats, antinociceptive effects of intraplantar and subcutaneous injection of FE 200665 and FE 200666 were measured by paw pressure algesiometry and compared with the kappa-agonist U-69,593. Peripheral and kappa-receptor selectivity was assessed by the antagonists naloxone methiodide (NLXM) and nor-binaltorphimine, respecti

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17

Dai, Guowei. "Bifurcation and standing wave solutions for a quasilinear Schrödinger equation." Proceedings of the Royal Society of Edinburgh: Section A Mathematics 149, no. 04 (2018): 939–68. http://dx.doi.org/10.1017/prm.2018.59.

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AbstractWe use bifurcation and topological methods to investigate the existence/nonexistence and the multiplicity of positive solutions of the following quasilinear Schrödinger equation$$\left\{ {\matrix{ {-\Delta u-\kappa \Delta \left( {u^2} \right)u = \beta u-\lambda \Phi \left( {u^2} \right)u{\mkern 1mu} {\mkern 1mu} } \hfill &amp; {{\rm in}\;\Omega ,} \hfill \cr {u = 0} \hfill &amp; {{\rm on}\;\partial \Omega } \hfill \cr } } \right.$$involving sublinear/linear/superlinear nonlinearities at zero or infinity with/without signum condition. In particular, we study the changes in the s

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18

Hattori, M., M. Nakashima, H. Katoh, et al. "Kappa-opioid, U-50488H, modulates polymorphonuclear leukocyte response induced by formyl peptide." European Journal of Pharmacology 183, no. 5 (1990): 1738–39. http://dx.doi.org/10.1016/0014-2999(90)92044-j.

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19

Shahzad, Naseer. "Approximation and Leray-Schauder type results for ${\mathcal U}_{c}^{\kappa}$ maps." Topological Methods in Nonlinear Analysis 24, no. 2 (2004): 337. http://dx.doi.org/10.12775/tmna.2004.031.

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20

Agarwal, Ravi P., and Donal O'Regan. "An essential map theory for ${\mathcal U}_c^{\kappa}$ and PK maps." Topological Methods in Nonlinear Analysis 21, no. 2 (2003): 375. http://dx.doi.org/10.12775/tmna.2003.023.

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D'ANDREA, S. V., E. T. MICHALSON, J. P. FREEMAN, C. G. CHIDESTER, and J. SZMUSZKOVICZ. "ChemInform Abstract: trans-3,4-Diaminopiperidines. Azacyclohexane Congeners of kappa Agonist U-50488." ChemInform 22, no. 43 (2010): no. http://dx.doi.org/10.1002/chin.199143144.

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22

Winkler, Michael. "Attractiveness of Constant States in Logistic-Type Keller–Segel Systems Involving Subquadratic Growth Restrictions." Advanced Nonlinear Studies 20, no. 4 (2020): 795–817. http://dx.doi.org/10.1515/ans-2020-2107.

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AbstractThe chemotaxis-growth system(⋆)\left\{\begin{aligned} \displaystyle u_{t}&\displaystyle=D\Delta u-\chi\nabla\cdot(u\nabla v)+\rho u-\mu u^{\alpha},\\ \displaystyle v_{t}&\displaystyle=d\Delta v-\kappa v+\lambda u\end{aligned}\right.is considered under homogeneous Neumann boundary conditions in smoothly bounded domains \Omega\subset\mathbb{R}^{n}, n\geq 1. For any choice of \alpha>1, the literature provides a comprehensive result on global existence for widely arbitrary initial data within a suitably generalized solution concept, but the regularity properties of such solution

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23

Xu, Wenna, Xinping Deng, Shanxin Guo, et al. "High-Resolution U-Net: Preserving Image Details for Cultivated Land Extraction." Sensors 20, no. 15 (2020): 4064. http://dx.doi.org/10.3390/s20154064.

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Accurate and efficient extraction of cultivated land data is of great significance for agricultural resource monitoring and national food security. Deep-learning-based classification of remote-sensing images overcomes the two difficulties of traditional learning methods (e.g., support vector machine (SVM), K-nearest neighbors (KNN), and random forest (RF)) when extracting the cultivated land: (1) the limited performance when extracting the same land-cover type with the high intra-class spectral variation, such as cultivated land with both vegetation and non-vegetation cover, and (2) the limite

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Milanes1, M. V., J. V. Rabadan, M. T. Marin, and M. L. Laorden. "Effects of U-50,488H on isolated atria from rats chronically treated with the kappa-opioid agonist, U-50,488H." Journal of Autonomic Pharmacology 18, no. 6 (1998): 371–75. http://dx.doi.org/10.1046/j.1365-2680.1998.1860371.x.

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Dragatsis, I., P. Papazafiri, C. Zioudrou, and K. Gerozissis. "Opioids modify the release of LH at the pituitary level: in vitro studies with entire rat pituitaries." Journal of Endocrinology 145, no. 2 (1995): 263–70. http://dx.doi.org/10.1677/joe.0.1450263.

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Abstract It is currently accepted that opioids modify the secretion of LH by affecting the release of GnRH in the hypothalamus. A direct action of opioids at the pituitary level is not yet fully established. To this end, we tested the effects of opioids on the release of LH by the entire pituitary in adult male rats. Opioid agonists with mu (DAGO), delta (DSLET) and kappa (U-50488H) specificity were tested at 0·01 to 10 μm in static incubations. DAGO inhibited dose-dependently the spontaneous and GnRH-induced release of LH. DSLET inhibited only the GnRH-induced release of LH. On the other hand

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Nagasaka, Hiroshi, Hamdy Awad, and Tony L. Yaksh. "Peripheral and Spinal Actions of Opioids in the Blockade of the Autonomic Response Evoked by Compression of the Inflamed Knee Joint." Anesthesiology 85, no. 4 (1996): 808–16. http://dx.doi.org/10.1097/00000542-199610000-00016.

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Background Three types of opioid receptors, mu, delta, and kappa, are present in the periphery and in the central nervous system. In contrast to the effects in the central nervous system, the antinociceptive action of opioids in the periphery is not as well characterized. The effects of intraarticular, spinal, and intramuscular injections of mu, delta, and kappa opioid agonists on the autonomic response evoked by compression of an inflamed knee joint were evaluated. Methods In halothane-anesthetized rats, arthritis was induced by injecting kaolin and carrageenan into the right knee joint. Stan

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Ticona, Luis Apaza, Nuria Cano-Adamuz, Andreea Madalina Serban та Ángel Rumbero Sánchez. "Inhibition of HIF-1α through Suppression of NF-κB Activation by Compounds Isolated from Senecio graveolens". Planta Medica International Open 7, № 01 (2020): e1-e11. http://dx.doi.org/10.1055/a-1063-6722.

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AbstractOne of the characteristics of cancer is that the lack of oxygen in the cancer cells triggers changes in their gene expression. This hypoxia activates hypoxia-inducible factor 1-alpha and this in turn sets in motion the whole family of important angiogenic genes for the tumour. Hypoxia-inducible factor 1-alpha therefore increases the density and vascular permeability within the tumours, facilitating their rapid growth and, later, the metastasis. Senecio graveolens is a South American medicinal plant commonly used for mountain sickness (lack of adaptation of the organism to hypoxia). Add

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Cao, Ruifen, Xi Pei, Ning Ge, and Chunhou Zheng. "Clinical Target Volume Auto-Segmentation of Esophageal Cancer for Radiotherapy After Radical Surgery Based on Deep Learning." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382110342. http://dx.doi.org/10.1177/15330338211034284.

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Radiotherapy plays an important role in controlling the local recurrence of esophageal cancer after radical surgery. Segmentation of the clinical target volume is a key step in radiotherapy treatment planning, but it is time-consuming and operator-dependent. This paper introduces a deep dilated convolutional U-network to achieve fast and accurate clinical target volume auto-segmentation of esophageal cancer after radical surgery. The deep dilated convolutional U-network, which integrates the advantages of dilated convolution and the U-network, is an end-to-end architecture that enables rapid t

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Tang, Andrew H. "Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent." Life Sciences 37, no. 16 (1985): 1475–82. http://dx.doi.org/10.1016/0024-3205(85)90178-x.

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Kunihara, M., M. Ohyama, M. Nakano, and S. Hayashi. "Analgesic activity of spiradoline mesylate (U-62,066E), a kappa opioid agonist in mice." Life Sciences 45, no. 13 (1989): 1191–98. http://dx.doi.org/10.1016/0024-3205(89)90508-0.

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Lin, Chuang, Shanxin Guo, Jinsong Chen, et al. "Deep Learning Network Intensification for Preventing Noisy-Labeled Samples for Remote Sensing Classification." Remote Sensing 13, no. 9 (2021): 1689. http://dx.doi.org/10.3390/rs13091689.

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The deep-learning-network performance depends on the accuracy of the training samples. The training samples are commonly labeled by human visual investigation or inherited from historical land-cover or land-use maps, which usually contain label noise, depending on subjective knowledge and the time of the historical map. Helping the network to distinguish noisy labels during the training process is a prerequisite for applying the model for training across time and locations. This study proposes an antinoise framework, the Weight Loss Network (WLN), to achieve this goal. The WLN contains three m

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Weller, Alexander, Ban Sharif, Mohammad H. Qarib, Dominic St Leger, Hakkini SL De Silva, and Ravi K. Lingam. "British Thyroid Association 2014 classification ultrasound scoring of thyroid nodules in predicting malignancy: Diagnostic performance and inter-observer agreement." Ultrasound 28, no. 1 (2019): 4–13. http://dx.doi.org/10.1177/1742271x19865001.

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Objectives To assess the inter-observer agreement amongst five observers of differing levels of expertise in applying the British Thyroid Association (2014) guidelines for ultrasound scoring of thyroid nodules (BTA-U score) in the management of thyroid cancer, and to assess the U-score diagnostic performance in predicting malignancy. Method A total of 73 consecutive patients were included over a two-year period (July 2012 to July 2014), after referral to a tertiary head and neck oncology centre for ultrasound plus fine needle aspiration and cytology. Our five observers retrospectively and inde

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PIEDADE, SERGIO ROCHA, DANIEL MIRANDA FERREIRA, MARK HUTCHINSON, NICOLA MAFFULLI, MARTHA MARIA MISCHAN, and PHILIPPE NEYRET. "IS THE “U-SIGN” RADIOLOGIC FEATURE OF A POSTERIOR CRUCIATE LIGAMENT TIBIAL AVULSION FRACTURE?" Acta Ortopédica Brasileira 29, no. 4 (2021): 189–92. http://dx.doi.org/10.1590/1413-785220212904240251.

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ABSTRACT Objective: By analyzing our cases of posterior cruciate ligament (PCL) tibial avulsion fracture, we noted that a U-shaped image was present in the anteroposterior plain radiographs view of the affected knee, even in cases where the profile view of the knee had been inconclusive as to tibial PCL avulsion fracture, a “hidden” fracture. Therefore, we aimed to investigate whether there was an anatomical correlation between this radiological U sign and the tibial insertion of the PCL and to ascertain the intra- and inter-rater reliability of this sign in clinical practice. Methods: The dat

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Tanihara, Hiroaki, Junzo Kamei, and Yutaka Kasuya. "Antitussive effects of kappa-opioid receptor agonists, U-50,488H and 0-62,066E, in rats." Japanese Journal of Pharmacology 52 (1990): 101. http://dx.doi.org/10.1016/s0021-5198(19)55129-0.

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Petrozza, P. H., W. S. Haddon, and D. S. Prough. "EFFECTS OF U-50488H, A SELECTIVE KAPPA ANALGESIC, ON CEREBRAL VASCULAR RESPONSIVITY IN DOGS." Anesthesiology 69, no. 3A (1988): A541. http://dx.doi.org/10.1097/00000542-198809010-00541.

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36

Erl, W., C. Weber, C. Wardemann, and P. C. Weber. "alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 2 (1997): H634—H640. http://dx.doi.org/10.1152/ajpheart.1997.273.2.h634.

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The adherence of monocytes to activated endothelium is an early event in atherogenesis. Because antioxidants have been considered to be of antiatherosclerotic potential, we investigated the effects of alpha-tocopherol (TCP) and its acetate and succinate esters on monocyte adhesion to cytokine-stimulated human umbilical vein endothelial cells (HUVEC). Endothelial cells were treated with TCP, alpha-tocopherol acetate (TCP acetate), or alpha-tocopheryl succinate (TCP succinate) before stimulation with tumor necrosis factor-alpha (TNF-alpha; 10 U/ml, 6 h) or interleukin-1 beta (IL-1 beta; 10 U/ml,

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Zappi, Lucia, Pingfong Song, Siriana Nicosia, Francesco Nicosia, and Kai Rehder. "Inhibition of Airway Constriction by Opioids Is Different down the Isolated Bovine Airway." Anesthesiology 86, no. 6 (1997): 1334–41. http://dx.doi.org/10.1097/00000542-199706000-00015.

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Background Opioid agonists attenuate in isolated airways contractile responses to electrical field stimulation (EFS), and this attenuation is mediated by opioid receptors. Differences exist in the density of muscarinic and beta-adrenergic receptors between large and small airways. The authors hypothesized that the density of opioid receptors may also be different down the airway. Methods The effects of three selective opioid agonists (mu, kappa, delta) on EFS-induced contractions were compared between isolated bovine sublobar (4- or 5-mm inner diameter) and segmental (2- or 3-mm inner diameter

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Cangiani, A., P. Chatzipantelidis, G. Diwan, and E. H. Georgoulis. "Virtual element method for quasilinear elliptic problems." IMA Journal of Numerical Analysis 40, no. 4 (2019): 2450–72. http://dx.doi.org/10.1093/imanum/drz035.

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Abstract A virtual element method for the quasilinear equation $-\textrm{div} ({\boldsymbol \kappa }(u)\operatorname{grad} u)=f$ using general polygonal and polyhedral meshes is presented and analysed. The nonlinear coefficient is evaluated with the piecewise polynomial projection of the virtual element ansatz. Well posedness of the discrete problem and optimal-order a priori error estimates in the $H^1$- and $L^2$-norm are proven. In addition, the convergence of fixed-point iterations for the resulting nonlinear system is established. Numerical tests confirm the optimal convergence properties

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Zhang, Shi-zhong, Ning-fu Wang, Jian Xu та ін. "κ-Opioid Receptors Mediate Cardioprotection by Remote Preconditioning". Anesthesiology 105, № 3 (2006): 550–56. http://dx.doi.org/10.1097/00000542-200609000-00019.

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Background Remote preconditioning is known to be cardioprotective, but the exact mechanism has not been fully elucidated. The objective of the current study was to investigate the role of kappa-opioid receptors in cardioprotection by remote preconditioning and reveal possible underlying mechanisms. Methods Remote preconditioning was induced in anesthetized male Sprague-Dawley rats by three cycles of 5 min of right femoral artery occlusion followed by 5 min of reperfusion. Myocardial ischemia-reperfusion was achieved by ligation of the left anterior descending coronary artery for 30 min and the

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Puig-Ramos, Anabel, Gladys S. Santiago, and Annabell C. Segarra. "U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats." Behavioral Neuroscience 122, no. 1 (2008): 151–60. http://dx.doi.org/10.1037/0735-7044.122.1.151.

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41

Tang, A. H., and R. J. Collins. "Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys." Psychopharmacology 85, no. 3 (1985): 309–14. http://dx.doi.org/10.1007/bf00428193.

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Heidbreder, Ch A., S. R. Goldberg, and T. S. Shippenberg. "The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat." Brain Research 616, no. 1-2 (1993): 335–38. http://dx.doi.org/10.1016/0006-8993(93)90228-f.

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Kamei, Junzo, Hiroaki Tanihara, and Yutaka Kasuya. "The Abilities of Specific .KAPPA.-Opioid Agonists, U-50,488H and U-62,066E, to Cause Antitussive Tolerance Were Lower than That of Morphine." Japanese Journal of Pharmacology 56, no. 4 (1991): 557–61. http://dx.doi.org/10.1254/jjp.56.557.

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Hudson, Christopher J., Philip F. Von Goigtlander, John S. Althaus, Heidi M. Scherch, and Eugene D. Means. "The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat." Brain Research 564, no. 2 (1991): 261–67. http://dx.doi.org/10.1016/0006-8993(91)91462-a.

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De Metz, Côme, Benjamin Hennart, Marie-Cecile Le Deley, et al. "Pre-therapeutic dihydropyridimidine dehydrogenase (DPD) deficiency screening: Impact on fluoropyrimidine dose reduction at the second chemotherapy cycle and on early severe toxicity." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3096. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3096.

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3096 Background: DPD deficiency screening before fluoropyrimidine is a matter of debate. To avoid lethal toxicity, French authorities impose DPD screening before fluoropyrimidine-based chemotherapy by dosing uracilemia since April 2019. Methods: We have included all consecutive adult patients receiving 5-fluorouracil (5-FU) or capecitabin from April 2019 to January 2020 in 6 cancer centers. During the study period, different methods for screening had been applied: DPYD complete sequencing, phenotype (uracilemia and/or dihydrouracilemia/uracilemia ratio - UH2/U -) or both. All sceening tests we

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Jernberg, H., K. Nilsson, L. Zech, D. Lutz, H. Nowotny, and W. Scheirer. "Establishment and phenotypic characterization of three new human myeloma cell lines (U-1957, U-1958, and U-1996)." Blood 69, no. 6 (1987): 1605–12. http://dx.doi.org/10.1182/blood.v69.6.1605.1605.

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Abstract Three new human myeloma cell lines (U-1957, U-1958, and U-1996) have been established in vitro. The cell lines are Epstein-Barr virus (EBV) negative, monoclonal, and aneuploid and should thus represent malignant cell populations and not EBV-carrying non-neoplastic B lymphoblastoid cell lines. The myeloma origin of the cell lines is also suggested by their capacity for production of monoclonal complete immunoglobulin (Ig) molecules (U-1957 and U-1958) or IgG light chains (U-1996) of the same type as the myeloma protein in vivo. All the cell lines have morphological features of plasmabl

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Jernberg, H., K. Nilsson, L. Zech, D. Lutz, H. Nowotny, and W. Scheirer. "Establishment and phenotypic characterization of three new human myeloma cell lines (U-1957, U-1958, and U-1996)." Blood 69, no. 6 (1987): 1605–12. http://dx.doi.org/10.1182/blood.v69.6.1605.bloodjournal6961605.

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Three new human myeloma cell lines (U-1957, U-1958, and U-1996) have been established in vitro. The cell lines are Epstein-Barr virus (EBV) negative, monoclonal, and aneuploid and should thus represent malignant cell populations and not EBV-carrying non-neoplastic B lymphoblastoid cell lines. The myeloma origin of the cell lines is also suggested by their capacity for production of monoclonal complete immunoglobulin (Ig) molecules (U-1957 and U-1958) or IgG light chains (U-1996) of the same type as the myeloma protein in vivo. All the cell lines have morphological features of plasmablasts-plas

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Magnaudet, Jacques. "A ‘reciprocal’ theorem for the prediction of loads on a body moving in an inhomogeneous flow at arbitrary Reynolds number – CORRIGENDUM." Journal of Fluid Mechanics 689 (December 5, 2011): 605–6. http://dx.doi.org/10.1017/jfm.2011.475.

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In Magnaudet (2011) an inertial contribution was overlooked during the derivation of (3.6). Indeed, when generalizing (E.5), which is valid for an irrotational velocity field $\tilde {\mathbi{U}} = \boldsymbol{\nabla} \tilde {\Phi } $, to (E.6) which holds for any velocity $\tilde {\mathbi{U}} $, an extra term $\int \nolimits \nolimits _{\mathscr{V}} (\tilde {\mathbi{U}} \ensuremath{-} \boldsymbol{\nabla} \tilde {\Phi } )\boldsymbol{\cdot} (\boldsymbol{\nabla} {\mathbi{U}}_{U} { \mathop{ + }\nolimits }^{T} \boldsymbol{\nabla} {\mathbi{U}}_{U} )\boldsymbol{\cdot} \hat {\mathbi{U}} \hspace{0.167

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Zhao, Shikai, Jeremiah P. Freeman, Philip F. Von Voigtlander, W. Jeffrey Howe, and Jacob Szmuszkovicz. "Structure-activity-relationship pertaining to the north-west region of the kappa opioid agonist, U-50,488." Bioorganic & Medicinal Chemistry Letters 4, no. 17 (1994): 2139–44. http://dx.doi.org/10.1016/s0960-894x(01)80117-7.

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Rimoy, GH, NK Bhaskar, DM Wright, and PC Rubin. "Mechanism of diuretic action of spiradoline (U-62066E)-a kappa opioid receptor agonist in the human." British Journal of Clinical Pharmacology 32, no. 5 (1991): 611–15. http://dx.doi.org/10.1111/j.1365-2125.1991.tb03960.x.

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