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1

Ohkubo, M., G. Uehara, J. Beyer, et al. "Standard measurement method for normal state resistance and critical current of resistively shunted Josephson junctions." Superconductor Science and Technology 35, no. 4 (2022): 045002. http://dx.doi.org/10.1088/1361-6668/ac4f3b.

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Abstract An important parameter of Josephson junctions (JJs) is the product of normal state resistance (R n) and critical current (I c) for designing superconductor analogue devices or digital circuits. Determination of R n and I c from voltage–current (U–I) characteristic curves often faces difficulties; in particular I c is considerably reduced by intrinsic thermal or extrinsic electrical noises. Here, we propose a standard measurement method of R n and intrinsic critical current (I ci) for high-T c superconductor (HTS) grain boundary JJs operated in liquid nitrogen and low-T c superconducto
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2

Doucet, M. Y., T. R. Jones, and A. W. Ford-Hutchinson. "Responses of equine trachealis and lung parenchyma to methacholine, histamine, serotonin, prostanoids, and leukotrienes in vitro." Canadian Journal of Physiology and Pharmacology 68, no. 3 (1990): 379–83. http://dx.doi.org/10.1139/y90-053.

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The responses of equine trachealis and lung parenchymal strips to a range of contractile agonists were studied. Equine trachealis responded to methacholine > histamine > serotonin as shown by the maximal responses but failed to respond to either leukotrienes (LT), prostaglandin F2α, or U-44069. Equine parenchymal strips showed considerable tonal activity and responded to LTD4[Formula: see text]LTC4 > U-44069 = LTE4 > methacholine [Formula: see text] histamine [Formula: see text] serotonin > prostaglandin F2α as determined through pD2 values. Neither the concentration response cu
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3

He, Shuai, Yinghua Zhang, Zhian Huang, Ge Zhang, and Yukun Gao. "Influence of Internal Structure and Composition on Head’s Local Thermal Sensation and Temperature Distribution." Atmosphere 11, no. 2 (2020): 218. http://dx.doi.org/10.3390/atmos11020218.

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A personalized thermal environment is an effective way to ensure a good thermal sensation for individuals. Since local thermal sensation and temperature distribution are affected by individual physiological differences, it is necessary to study the effects of physiological parameters. The purpose of this study was to investigate the effects of internal structures and tissue composition on head temperature distribution and thermal sensation. A new mathematical model based on fuzzy logic control was established, the internal structure and tissue composition of the head were obtained by magnetic
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4

Telzerow, Eva, Dennis Görlich, Maja Rothenberg-Thurley, et al. "Quality of Life and Life Satisfaction in AML Long-Term Survivors: Primary Results of the AMLCG-Survivorship Study." Blood 138, Supplement 1 (2021): 2289. http://dx.doi.org/10.1182/blood-2021-147027.

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Abstract Introduction An increasing proportion of patients with Acute Myeloid Leukemia (AML) become long-term survivors. Somatic and psycho-social outcomes are therefore becoming increasingly important, but little is known about the long-term effects of the disease and its treatment. Methods We designed a comprehensive analysis of AML survivorship outcomes including psycho-social well-being and somatic health status and conducted a questionnaire-based study collecting data from AML long term survivors (AML-LTS) and their physicians. This report focuses on overall and health-related quality of
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5

Bakhsham, Milad, Mahdi Hosseinpour, Masoumeh Ayeneh, Hossein Karimi, and Parisa Parandavar. "Identifying and Analyzing the Application of the Internet of Things in Supply Pharmaceutical Chain Agility in post COVID -19." Journal of Health and Biomedical Informatics 10, no. 1 (2023): 57–69. http://dx.doi.org/10.34172/jhbmi.2023.14.

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Introduction: The internet of Things has become more popular as a new technology since the advent of wire less technology , and attracted attention from supply chain management promoters. This study aimed to identify and analyze IoT applications in the pharmaceutical supply chain agility in the post -COVID -19 era Method: We first review previous studies in appl ications of IoT in pharmaceutical supply chain agility and identified the findings through qualitative content analysis. Then, the identified factors were given to 20 management and information technology experts to confirm and validat
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6

Omkar, Manohar Ghag. "Comparative Analysis of u-blox and Quectel LTE Modem Chipsets: Technical Specifications, Performance, and Application Suitability." European Journal of Advances in Engineering and Technology 8, no. 8 (2021): 56–59. https://doi.org/10.5281/zenodo.13235643.

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This study compares LTE modem chipset leaders u-blox and Quectel. Developers, manufacturers, and academics are advised on technology features, benchmarks, and applicability in the article. Modern communication systems use LTE technology for fast data transmission, low latency, and reliable device and application connectivity. Companies creating connectivity solutions and expecting high performance in varied environments need a super-fit LTE modem chipset. A detailed comparison of u-blox and Quectel LTE modem chipset hardware begins the study. Powerful chipsets with several cores and RAM are fa
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7

Reddy, S. Reddy Vamshidhar, and Sanjay Dhar Roy. "SBT (Sense Before Transmit) Based LTE Licenced Assisted Access for 5 GHz Unlicensed Spectrum." Wireless Personal Communications 119, no. 3 (2021): 2069–81. http://dx.doi.org/10.1007/s11277-021-08318-1.

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AbstractUtilization of unlicensed spectrum under licensed assisted access ensuring fair co-existence with Wi-Fi networks is a good solution to address immense usage of mobile data. Radio communication operation of LTE in unlicensed frequency band is referred as LTE-unlicensed (LTE-U) or LTE-licensed assisted access. In this paper, we consider a HGNW in which coverage area of Wireless-Fidelity (Wi-Fi)’s Access Point is integrated within the LTE-U small base station’s cellular network coverage area. To overcome the disadvantages of existing LTE-U technics like carrier sense adaptive transmission
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8

Girmay, Merkebu, Vasilis Maglogiannis, Dries Naudts, Adnan Shahid, and Ingrid Moerman. "Coexistence Scheme for Uncoordinated LTE and WiFi Networks Using Experience Replay Based Q-Learning." Sensors 21, no. 21 (2021): 6977. http://dx.doi.org/10.3390/s21216977.

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Nowadays, broadband applications that use the licensed spectrum of the cellular network are growing fast. For this reason, Long-Term Evolution-Unlicensed (LTE-U) technology is expected to offload its traffic to the unlicensed spectrum. However, LTE-U transmissions have to coexist with the existing WiFi networks. Most existing coexistence schemes consider coordinated LTE-U and WiFi networks where there is a central coordinator that communicates traffic demand of the co-located networks. However, such a method of WiFi traffic estimation raises the complexity, traffic overhead, and reaction time
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9

Zhiqun, Hu, Lu Zhaoming, Lin Shangjuan, Wen Xiangming, and Xu Hen. "Performance analysis of LTE-U coexistence network with WiFi using queueing model." Journal of China Universities of Posts and Telecommunications 24, no. 5 (2017): 1–7. http://dx.doi.org/10.1016/s1005-8885(17)60227-9.

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10

Yılmaz, Yusuf, and Rasim Behçet. "Kütahya Zafer Havalimanını Kullanan Uçaklardan Kaynaklanan Emisyonlar." EJONS International Journal on Mathematic, Engineering and Natural Sciences 8, no. 1 (2024): 66–75. https://doi.org/10.5281/zenodo.10813158.

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Bu araştırmada, K&uuml;tahya Zafer Havalimanı'na 2022 yılında iniş ve kalkış yapan u&ccedil;aklardan kaynaklanan emisyonların &ccedil;evresel etkilerini incelemeyi hedeflenmiştir. Bu ama&ccedil;la, 2022 yılı i&ccedil;inde havalimanına varan ve havalimanından kalkan u&ccedil;aklardan yayılan CO<sub>2</sub>, HC, CO ve NOx emisyonları, IPCC metodolojisi ve Tier 2 y&ouml;ntemi kullanılarak hesaplanmıştır. Hesaplamalarda, havalimanına iniş ve kalkış yapan sivil u&ccedil;ak t&uuml;rlerine g&ouml;re LTO (Landingand Take Off) sayıları, u&ccedil;uş aşamalarına g&ouml;re CO<sub>2</sub>, HC, CO, NOx emis
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11

Baswade, Anand M., Mohith Reddy, Antony Franklin A., Bheemarjuna Reddy Tamma, and Vanlin Sathya. "Performance analysis of spatially distributed LTE-U/NR-U and Wi-Fi networks: An analytical model for coexistence study." Journal of Network and Computer Applications 191 (October 2021): 103157. http://dx.doi.org/10.1016/j.jnca.2021.103157.

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12

Asadov, Mirsalim M., Solmaz N. Mustafaeva, Saida O. Mammadova, Esmira S. Kuli-Zade, and Vladimr F. Lukichev. "Modeling of Structural Properties of Zr(Nb)-Doped c-LTO–Zr(Nb) Materials With Spinel Structure for Li-Ion Batteries." WSEAS TRANSACTIONS ON ELECTRONICS 15 (December 31, 2024): 166–83. https://doi.org/10.37394/232017.2024.15.19.

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Using the density functional theory (DFT), we investigated the electronic, magnetic and energy properties of Li4Ti5-xMxO12 (M = Zr, Nb; x = 0–0.01) (or c-LTO–Zr (Nb)) supercells, which are isostructural to the high-temperature spinel (cubic; sp.gr. 𝐹𝑑3̅𝑚) modification of the Li4Ti5O12-based anode material (c-LTO) for lithium-ion batteries (LIB). In DFT calculations with a generalized gradient approximation (functional GGA), spin-orbit coupling (SOC) and the Hubbard correction were considered (DFT SGGA+ 𝑈). For the Ti 3d and Zr(Nb) 4d states, pd and dd-model values of the U effective interactio
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13

Przesmycki, Rafał, and Marek Bugaj. "Crescent Microstrip Antenna for LTE-U and 5G Systems." Electronics 11, no. 8 (2022): 1201. http://dx.doi.org/10.3390/electronics11081201.

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The field of wireless cellular network technology has seen a significant development in recent years, allowing the emergence of many new applications in addition to the traditional mobile phone calls. We are currently implementing the 5G system, which is replacing the previous cellular technologies on the market. Parallel to the development of cellular technologies, wireless local networks based on the IEEE 802.11× standards are rapidly spreading. The desire to use the advantages of both mobile telephony and wireless local networks has led to the idea of integrating the currently used communic
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14

Ogiwara, Kenichi, Shoko Furukawa, Kana Sasai, Keito Inaba, Takehisa Kitazawa, and Keiji Nogami. "Effects of Bypassing Hemostatic Agents in the Co-Presence of NXT007, Emicizumab-Based Engineered Bispecific Antibody to Fixa/Fx, Using in Vitro Global Assays: Rough Indicators for Their Concomitant Use." Blood 138, Supplement 1 (2021): 2114. http://dx.doi.org/10.1182/blood-2021-149412.

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Abstract Background: NXT007, emicizumab (Emi)-based engineered therapeutic bispecific antibody which increases tissue factor (TF)-triggered thrombin generation (TG) potential of factor(F) VIII-deficient plasma to non-hemophiliac ranges at around 5-30 μg/mL (Yamaguchi, ASH 2020), is currently in a phase 1/2 clinical study. In the clinical settings under NXT007-prophylaxis, bypassing hemostatic agents (BPAs), such as activated prothrombin complex concentrates (aPCC) and recombinant(r) FVIIa, may be concomitantly administered. Under Emi-prophylaxis, repeated doses of aPCC impose a thrombotic risk
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15

Muto, Atsushi, Takehisa Kitazawa, Kazutaka Yoshihasi, et al. "Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model." Blood 120, no. 21 (2012): 42. http://dx.doi.org/10.1182/blood.v120.21.42.42.

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Abstract Abstract 42 Background: Hemophilia A is treated by intravenous replacement therapy with factor VIII (FVIII), either on demand to resolve bleeding or as a prophylactic to prevent bleeding. Recently, routine prophylactic treatment is recommended to effectively prevent bleeding and to reduce bleeding-related chronic joint damage. However, the need for frequent intravenous injections of FVIII negatively affects patients' quality of life and their adherence to the routine prophylactic regimen. More importantly, approximately 30% of severe hemophilia A patients develop inhibitory antibodies
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16

Liang, Hao, Hongli Zhao, Shuo Wang, and Yong Zhang. "LTE-U based Train to Train Communication System in CBTC: System Desin and Reliability Analysis." Wireless Communications and Mobile Computing 2020 (December 30, 2020): 1–14. http://dx.doi.org/10.1155/2020/8893631.

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Communication-Based Train Control (CBTC) system is a critical signal system to ensure rail transit’s safe operation. Compared with the train-ground CBTC system, the train control system based on train-to-train (T2T) communication has the advantages of fast response speed, simple structure, and low operating cost. As the core part of the train control system based on T2T communication, the reliability of the data communication system (DCS) is of great significance to ensure the train’s safe and efficient operation. According to the T2T communication system requirements, this paper adopts Long-T
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17

Mohammad-Rahimi, Hossein, Shankeeth Vinayahalingam, Erfan Mahmoudinia, et al. "Super-Resolution of Dental Panoramic Radiographs Using Deep Learning: A Pilot Study." Diagnostics 13, no. 5 (2023): 996. http://dx.doi.org/10.3390/diagnostics13050996.

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Using super-resolution (SR) algorithms, an image with a low resolution can be converted into a high-quality image. Our objective was to compare deep learning-based SR models to a conventional approach for improving the resolution of dental panoramic radiographs. A total of 888 dental panoramic radiographs were obtained. Our study involved five state-of-the-art deep learning-based SR approaches, including SR convolutional neural networks (SRCNN), SR generative adversarial network (SRGAN), U-Net, Swin for image restoration (SwinIr), and local texture estimator (LTE). Their results were compared
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18

Kroupa, Michal, Sivaramakrishna Rachakonda, Veronika Vymetálková, et al. "Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients." Mutagenesis 35, no. 6 (2020): 491–97. https://doi.org/10.1093/mutage/geaa030.

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Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and clinicopathological features in the BC patients since these associations are insufficiently explored at present. LTL was measured in 611 BC patients and 154 healthy controls using the monochrome multiplex quantitative Polymerase Chain Reaction assay. In addition, we genotyped nine TL-associated single-nucleotide polymorphisms that had been identifie
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19

Petzer, A. L., C. J. Eaves, M. J. Barnett, and A. C. Eaves. "Selective Expansion of Primitive Normal Hematopoietic Cells in Cytokine-Supplemented Cultures of Purified Cells From Patients With Chronic Myeloid Leukemia." Blood 90, no. 1 (1997): 64–69. http://dx.doi.org/10.1182/blood.v90.1.64.

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Abstract We have previously reported that primitive normal hematopoietic cells detectable as long-term culture-initiating cells (Ph-LTC-IC) are present at high levels in the blood of some patients with chronic myeloid leukemia (CML). We now show that this population can be expanded several-fold when highly purified CD34+CD38− cells isolated from the blood of such patients are cultured for 10 days in a serum-free medium containing 100 ng/mL of Flt3-ligand and Steel factor and 20 ng/mL of interleukin-3 (IL-3) and IL-6, and granulocyte colony-stimulating factor. In similar cultures initiated with
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20

Petzer, A. L., C. J. Eaves, M. J. Barnett, and A. C. Eaves. "Selective Expansion of Primitive Normal Hematopoietic Cells in Cytokine-Supplemented Cultures of Purified Cells From Patients With Chronic Myeloid Leukemia." Blood 90, no. 1 (1997): 64–69. http://dx.doi.org/10.1182/blood.v90.1.64.64_64_69.

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We have previously reported that primitive normal hematopoietic cells detectable as long-term culture-initiating cells (Ph-LTC-IC) are present at high levels in the blood of some patients with chronic myeloid leukemia (CML). We now show that this population can be expanded several-fold when highly purified CD34+CD38− cells isolated from the blood of such patients are cultured for 10 days in a serum-free medium containing 100 ng/mL of Flt3-ligand and Steel factor and 20 ng/mL of interleukin-3 (IL-3) and IL-6, and granulocyte colony-stimulating factor. In similar cultures initiated with CD34+CD3
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21

Li, Junjun, Jingyu Yang, Bowei Xu, Yongsheng Yang, Furong Wen, and Haitao Song. "Hybrid Scheduling for Multi-Equipment at U-Shape Trafficked Automated Terminal Based on Chaos Particle Swarm Optimization." Journal of Marine Science and Engineering 9, no. 10 (2021): 1080. http://dx.doi.org/10.3390/jmse9101080.

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Aimed to improve the efficiency of port operations, Shanghai Zhenhua Heavy Industries Co., Ltd. (ZPMC) proposed a new U-shape trafficked automated terminal. The new U-shape trafficked automated terminal brings a new hybrid scheduling problem. A hybrid scheduling model for yard crane (YC), AGV and ET in the U-shape trafficked automated terminal yard is established to solve the problem. The AGV and ET yard lanes are assumed to be one-way lane. Take the YC, AGV and ET scheduling results (the container transportation sequences) as variables and the minimization of the maximum completion time as th
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22

Kuo, Chia-Ling, Ben Kirk, Meiruo Xiang, et al. "Very Low and High Levels of Vitamin D Are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants." Nutrients 15, no. 6 (2023): 1474. http://dx.doi.org/10.3390/nu15061474.

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Background: Shorter leukocyte telomere length (LTL) is observed in multiple age-related diseases, which are also associated with vitamin D deficiency (i.e., osteosarcopenia, neurocognitive disorders, cancer, osteoarthritis, etc.), suggesting a close association between vitamin D and LTL. In this study, we examined the relationship between vitamin D levels and LTL in older participants of the UK Biobank. Methods: Data were collected from the UK Biobank. Participants aged 60 and older (n = 148,321) were included. Baseline LTL was measured using a multiplex qPCR technique and expressed as the rat
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23

Selleri, C., JP Maciejewski, T. Sato, and NS Young. "Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition." Blood 87, no. 10 (1996): 4149–57. http://dx.doi.org/10.1182/blood.v87.10.4149.bloodjournal87104149.

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Clinical and laboratory studies have suggested involvement of interferon-gamma (IFN-gamma) in the pathophysiology of aplastic anemia. T cells from aplastic anemia (AA) patients secrete IFN-gamma in vitro, activated cytotoxic lymphocytes infiltrate aplastic bone marrow (BM), and IFN-gamma mRNA, not detected in normal BM, is present in BM from most AA patients. Many patients respond to immunosuppressive therapy with antithymocyte globulin and cyclosporine. Using long-term BM cultures (LTBMC) as a tissue culture model of hematopoiesis, we show that IFN-gamma is a potent inhibitor in the long-term
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24

Hummel, W., K. Horne, T. R. Marsh, and Janet H. Wood. "Line Formation in U Gem and T Leo." International Astronomical Union Colloquium 158 (1996): 87–88. http://dx.doi.org/10.1017/s0252921100038318.

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We present 3-D LTE radiative transfer calculations [1] for H, He and Ca in accretion disks (AD) of dwarf novae in quiescence. The model disk is assumed to be in hydrostatic equilibrium vertically, and to rotate with Keplerian velocities. Calculated emission lines are fitted to phase-averaged, continuum-subtracted spectra of U Gem (Fig. 1) and T Leo (Fig. 2). Up to four parameters of the AD have been fitted: distance D, baryonic number density N, isotropic turbulence Vtu and disk temperature T; the latter two are assumed to be constant throughout the disk. Geometrical parameters are from [2] an
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25

VanScoy, Brian D., Elizabeth A. Lakota, Sujata M. Bhavnani, et al. "1379. Determination of the Arbekacin Exposure Required to Prevent Amplification of Resistant Subpopulations Using Patient Pharmacokinetics Simulated in a Hollow-Fiber Infection Model (HFIM)." Open Forum Infectious Diseases 5, suppl_1 (2018): S422—S423. http://dx.doi.org/10.1093/ofid/ofy210.1210.

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Abstract Background ME1100 (arbekacin inhalational solution) is an aminoglycoside in clinical development for the treatment of patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP, respectively). Due to the increase in resistance of Staphylococcus aureus and Pseudomonas aeruginosa to many antimicrobial agents, it is important to understand the relationships between amplification of drug resistance and each of drug exposure and therapy duration. The objective of the studies described herein was to utilize the HFIM to determine the arbekacin exposure after
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26

Fujii, T., K. Murata, H. Onizawa, et al. "OP0190 A MACHINE LEARNING MODEL THAT PREDICTS RA PROGRESSION FROM UNDIFFERENTIATED ARTHRITIS -KURAMA AND ANSWER COHORT STUDY-." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 126. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1476.

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BackgroundEarly diagnosis and treatment of rheumatoid arthritis (RA) improve clinical outcomes. Undifferentiated arthritis (UA) is arthritis that does not fit a specific diagnosis. Half of the UA undergo spontaneous remission, while 30% of cases develop RA. Therefore, in UA, identifying patients at high risk for developing RA and providing close monitoring for those patients is required for early diagnosis and treatment[1]). However, predicting the evolution of UA to RA is still difficult.ObjectivesMachine learning, including deep learning, which is comparable to and in some cases surpasses th
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27

Yim, Seongjin, and Wongun Kim. "Rollover Prevention Control for Autonomous Electric Road Sweeper." Electronics 10, no. 22 (2021): 2790. http://dx.doi.org/10.3390/electronics10222790.

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This paper presents a method to prevent the rollover of autonomous electric road sweepers (AERS). AERS have an articulated frame steering (AFS) mechanism. Moreover, the heights of the center of gravity of the front and rear bodies are high. As such, they are prone to rolling over at low speeds and at small articulation angles. A bicycle model with a nonlinear tire model was used as a vehicle model for AERS. Using that vehicle model, path tracking and speed controllers were designed in order to follow a predefined path and speed profile, respectively. To check the rollover propensity of AERS, l
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28

Chaib, Latifa, Abdelhak Ait Lahna, Hassan Admou, et al. "Geochemistry and Geochronology of the Neoproterozoic Backarc Basin Khzama Ophiolite (Anti-Atlas Mountains, Morocco): Tectonomagmatic Implications." Minerals 11, no. 1 (2021): 56. http://dx.doi.org/10.3390/min11010056.

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The Khzama ophiolite is a highly dismembered complex located in the Siroua inlier of the Moroccan Anti-Atlas Belt. It consists of ultramafic rocks, cumulate gabbros, sheeted dikes, pillow lavas, and an overlying volcano-sedimentary sequence. Three main tectonic slices of sheeted dike complexes are studied in detail along three rivers, exposing well preserved outcrops where individual dikes are clearly distinguishable from the intruded host rock (Assif n’Tinzla, Assif n’Tasriwine, and Assif n’Iriri). Sheeted dikes of the Khzama ophiolitic complex are basaltic to andesitic in composition, displa
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Chaib, Latifa, Abdelhak Ait Lahna, Hassan Admou, et al. "Geochemistry and Geochronology of the Neoproterozoic Backarc Basin Khzama Ophiolite (Anti-Atlas Mountains, Morocco): Tectonomagmatic Implications." Minerals 11, no. 1 (2021): 56. http://dx.doi.org/10.3390/min11010056.

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The Khzama ophiolite is a highly dismembered complex located in the Siroua inlier of the Moroccan Anti-Atlas Belt. It consists of ultramafic rocks, cumulate gabbros, sheeted dikes, pillow lavas, and an overlying volcano-sedimentary sequence. Three main tectonic slices of sheeted dike complexes are studied in detail along three rivers, exposing well preserved outcrops where individual dikes are clearly distinguishable from the intruded host rock (Assif n’Tinzla, Assif n’Tasriwine, and Assif n’Iriri). Sheeted dikes of the Khzama ophiolitic complex are basaltic to andesitic in composition, displa
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30

Chen, Nianhang, Abderrahmane Laadem, Dawn M. Wilson, et al. "Pharmacokinetics and Exposure-Response of Luspatercept in Patients with Anemia Due to Low- or Intermediate-1-Risk Myelodysplastic Syndromes (MDS): Preliminary Results from Phase 2 Studies." Blood 128, no. 22 (2016): 1990. http://dx.doi.org/10.1182/blood.v128.22.1990.1990.

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Abstract Background: Luspatercept is a modified ActRIIB-IgG Fc fusion protein that corrects ineffective erythropoiesis. In phase 2 studies, luspatercept treatment led to long-term increases in hemoglobin (Hb) levels and reduction in transfusion burden in patients (pts) with IPSS Low- or Intermediate-1-risk MDS. Aims: To characterize the pharmacokinetics (PK) of luspatercept and explore the exposure-response relationship for efficacy and safety in pts with MDS, thereby informing selection of the starting dose for phase 3 studies of luspatercept in MDS. Methods : PK, safety, and efficacy data we
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31

Misaki, K., E. Tanaka, E. Inoue, et al. "POS0603 ANALYSIS OF FACTORS ASSOCIATED WITH THE EFFECTIVENESS OF ABATACEPT IN THE ORIGAMI STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 536. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1028.

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Background:The ORIGAMI study is a multicenter, observational study to evaluate the effectiveness, safety, and patient-reported outcomes of abatacept (ABA) in Japanese patients with csDMARD-resistant, Simplified Disease Activity Index (SDAI)-moderate, biologic-naïve rheumatoid arthritis (RA). ABA has shown better effectiveness/efficacy in RA patients with anti-cyclic citrullinated peptide antibody (ACPA) positive (1) and high ACPA titer (2) compared to ACPA negative and low ACPA titer, respectively. However, more accurate predictors of effectiveness in clinical practice are needed than ACPA sta
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32

Liu, Xiaoyang, Shengzhuo Liu, Xin Yan, Jing Zhou, Yunfei Yu, and Qiang Dong. "Phenotypic and genetically predicted leukocyte telomere length and prostate cancer risk: Results from a large-scale longitudinal cohort study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 404. https://doi.org/10.1200/jco.2025.43.5_suppl.404.

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404 Background: Previous studies on the correlation between leukocyte telomere length (LTL) and prostate cancer (PCa) have shown contradictory results. Our study aims to further explore the potential relationship between LTL and PCa. Methods: In this study, a total of 229,022 male individuals were enrolled from the UK Biobank to investigate this association . Both unadjusted and covariates-adjusted Cox proportional hazards regression models were employed. The primary outcome was defined as the diagnosis of incident prostate cancer using in-patient data and the death registry of the UKB cohort.
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33

Hesselink, Wim H. "UNITY and Büchi automata." Formal Aspects of Computing 33, no. 2 (2021): 185–205. http://dx.doi.org/10.1007/s00165-020-00528-x.

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AbstractUNITY is a model for concurrent specifications with a complete logic for proving progress properties of the form “P leads to Q”. UNITY is generalized to U-specifications by giving more freedom to specify the steps that are to be taken infinitely often. In particular, these steps can correspond to non-total relations. The generalization keeps the logic sound and complete. The paper exploits the generalization in two ways. Firstly, the logic remains sound when the specification is extended with hypotheses of the form “F leads to G”. As the paper shows, this can make the logic incomplete.
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34

Imanishi, Masatoshi, Shunsuke Baba, Kouichiro Nakanishi, and Takuma Izumi. "Dense Molecular Gas Properties of the Central Kiloparsec of Nearby Ultraluminous Infrared Galaxies Constrained by ALMA Three Transition-line Observations." Astrophysical Journal 950, no. 1 (2023): 75. http://dx.doi.org/10.3847/1538-4357/acc388.

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Abstract We report the results of Atacama Large Millimeter/submillimeter Array (ALMA) 1–2 kpc resolution, three rotational transition-line (J = 2–1, J = 3–2, and J = 4–3) observations of multiple dense molecular gas tracers (HCN, HCO+, and HNC) for 10 nearby (ultra)luminous infrared galaxies ((U)LIRGs). Following the matching of beam sizes to 1–2 kpc for each (U)LIRG, the high-J-to-low-J transition-line flux ratios of each molecule and the emission-line flux ratios of different molecules at each J transition are derived. We conduct RADEX non-LTE model calculations and find that, under a wide r
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35

Ogiwara, Kenichi, Hiroki Horiuchi, Keiji Nogami, Takehisa Kitazawa, and Midori Shima. "Assessment of Emicizumab-Driven Clot Stability in Hemophilia a Model." Blood 132, Supplement 1 (2018): 2478. http://dx.doi.org/10.1182/blood-2018-99-118379.

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Abstract Clot stability is an important hemostatic aspect in treating patients with hemophilia A (HA). Effects of factor VIII (FVIII), recombinant activated FVII (rFVIIa), FXIII and tranexamic acid on clot stability in hemophilia had been reported1). Emicizumab (Emi), FVIIIa-mimicking bispecific antibody, is a recently approved novel therapeutics for HA with inhibitor. Although hemostatic activity of Emi was confirmed by preclinical and clinical studies, whether Emi-driven clot stability is similar to that of FVIII or not remains unknown. Furthermore, in clinical trial of Emi, thrombotic event
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36

Jeong, Yonghwan, Wongun Kim, and Seongjin Yim. "Model Predictive Control Based Path Tracking and Velocity Control with Rollover Prevention Function for Autonomous Electric Road Sweeper." Energies 15, no. 3 (2022): 984. http://dx.doi.org/10.3390/en15030984.

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This paper presents a model predictive control (MPC)-based algorithm for rollover prevention of an autonomous electric road sweeper (AERS). For AERS, the basic function of autonomous driving is a path- and velocity-tracking control needed to make a vehicle follow given path and velocity profiles. On the other, the AERS adopts an articulated frame steering (AFS) mechanism which can make cornering behavior agile. Moreover, the tread of the AERS is narrow, and the height of the mass center is high. As a result, it is prone to roll over. For this reason, it is necessary to design a controller for
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Arai, Ayako, Masahide Yamamoto, Maho Sato, et al. "The Outcomes of Systemic Chronic Active EBV Infection Treatment By Allogeneic Hematopoietic Stem Cell Transplantation: An Analysis of Japanese Registry Data." Blood 138, Supplement 1 (2021): 3965. http://dx.doi.org/10.1182/blood-2021-147046.

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Abstract Background and aims Systemic chronic active Epstein-Barr virus infection (sCAEBV) is classified as T- or NK-cell neoplasms in the WHO classification revised in 2017. Although allogeneic stem cell transplantation (allo-HSCT) is efficacious for sCAEBV, the effects are yet to be analyzed in a large number of cases due to the disease rarity. To investigate the outcomes and the prognostic factors of allo-HSCT in sCAEBV under the definition of the WHO 2017 classification, we analyzed retrospectively using the database of Japanese Society for Transplantation and Cellular Therapy (JSTCT). Met
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38

Yamaguchi, Kazuki, Tetsuhiro Soeda, Motohiko Sato, et al. "Pharmacology and Pharmacokinetics of NXT007; Emicizumab-Based Engineered Fixa/Fx Bispecific Antibody with Improved Properties." Blood 136, Supplement 1 (2020): 19. http://dx.doi.org/10.1182/blood-2020-138958.

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Background Emicizumab (HEMLIBRA®) is a factor (F) VIII function-mimetic therapeutic bispecific antibody (BsAb) to FIXa and FX able to prevent bleeding in persons with hemophilia A (PwHA) when injected subcutaneously once every 1, 2 or 4 weeks. To develop a next generation version, we sought an agent able to keep hemostatic potential in non-hemophilic range with more convenient dosing regimen (dosing frequency/volume). We successfully created the emicizumab-based engineered four-chain BsAbs, NXT series. Among these, we selected NXT007 as a clinical candidate. Objectives The aim of this study is
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39

Chen, Meng-Han, Guanling Lee, and Lun-Ping Hung. "AI-Driven Data Analysis for Asthma Risk Prediction." Healthcare 13, no. 7 (2025): 774. https://doi.org/10.3390/healthcare13070774.

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Background: Asthma is a well-known otolaryngological and immunological disorder that affects patients worldwide. Currently, the primary diagnosis relies on a combination of clinical history, physical examination findings consistent with asthma, and objective evidence of reversible airflow obstruction. However, the diagnostic process can be invasive and time-consuming, which limits clinical efficiency and accessibility. Objectives: In this study, an AI-based prediction system was developed, leveraging voice changes caused by respiratory contraction due to asthma to create a machine learning (ML
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40

Saidah, Karimatus, and Rian Damariswara. "Pengembangan Bahan Ajar Materi Dongeng Berbasis Kearifan Lokal Jawa Timur Bagi Siswa Kelas III SD." Premiere Educandum : Jurnal Pendidikan Dasar dan Pembelajaran 9, no. 1 (2019): 73. http://dx.doi.org/10.25273/pe.v9i1.4320.

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&lt;p class="normal" align="center"&gt;&lt;span dir="LTR"&gt;&lt;strong&gt;Abstrak &lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;&lt;p class="normal"&gt; &lt;/p&gt;&lt;p class="normal" align="justify"&gt;&lt;span dir="LTR"&gt;Tujuan dari penelitian ini adalah (1)untuk mengembangkan bahan ajar materi dongeng yang di peruntukkan kelas tiga sekolah dasar dengan mengangkat kearifan lokal Jawa Timur (2) Mengetahui kevalidan bahan ajar materi dongeng yang telah dikembangkan (3) Mengetahui kepraktisan bahan ajar materi dongeng yang telah dikembangkan. Metode penelitian yang digunakan adalah model penelitian
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Imaseki, Hitoshi, and Masae Yukawa. "Introduction of PIXE analysis system in NIRS." International Journal of PIXE 10, no. 03n04 (2000): 77–90. http://dx.doi.org/10.1142/s0129083500000122.

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In March 1999, electrostatic accelerator, Tandetron (Model 4117MC, High Voltage Engineering Europe Co.) was installed in the Electrostatic Accelerator Building for PIXE (Particle Induced X-ray Emission) analysis. The accelerating voltage is 0.4 to 1.7MV, and the maximum beam current is 5μA at 3.4MeV. This system has three beam ports for different types of PIXE analysis: normal, micro-beam and in-air. The first beam port is used for normal PIXE. Since two types of X-ray detecting device, Si ( Li ) and CdZnTe detectors, are available here, elements from Na ( Z =11) to U ( Z =92) are detectable.
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42

Deming, D., T. Hewagama, D. E. Jennings, G. McCabe та G. Wiedemann. "Vector Magnetometry Using the 12-μm Emission Lines". Symposium - International Astronomical Union 154 (1994): 379–92. http://dx.doi.org/10.1017/s0074180900124659.

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Recent polarimetric observations of the 12.32-μm emission line have provided the observational basis for deriving vector magnetic fields in the upper photosphere with great sensitivity. We use a line source function from the non-LTE model of Carlsson, Rutten and Shchukina, and calculate the radiative transfer of the Stokes I, Q, U, and V profiles. The results show that the profiles are not significantly affected by magneto-optical effects or by saturation, and reliable vector fields can be extracted by simply fitting the Seares relations to the Stokes profiles. Vector field observations for su
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Manouare, Ahmed Zakaria, Saida Ibnyaich, Divitha Seetharamdoo, Abdelaziz EL Idrissi, and Abdelilah Ghammaz. "Design, Fabrication and Measurement of a Novel Compact Triband CPW-Fed Planar Monopole Antenna Using Multi-type Slots for Wireless Communication Applications." Journal of Circuits, Systems and Computers 29, no. 02 (2019): 2050032. http://dx.doi.org/10.1142/s0218126620500322.

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A novel compact coplanar waveguide (CPW)-fed planar monopole antenna with triple-band operation is presented for simultaneously satisfying the LTE 2600, WiMAX, WLAN and X-band applications. It is printed on a single-layered FR4 substrate. In this paper, the proposed antenna, which occupies a small volume of [Formula: see text][Formula: see text]mm3 including the ground plane, is simply composed of a CPW-fed monopole with U-, L- and T-shaped slots. By carefully selecting the lengths and positions of both L-shaped and U-shaped slots, a good dual notched band characteristic at center-rejected fre
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44

Kim, Yong Suk, Ho Jung Song, and Ju Hyuck Han. "A Study on the Development of Deepfake-Based Deep Learning Algorithm for the Detection of Medical Data Manipulation." Webology 19, no. 1 (2022): 4396–409. http://dx.doi.org/10.14704/web/v19i1/web19289.

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In the medical field, the abuse of manipulation data through image processing technology of deep learning is fatal. Therefore, research on detection of modulation on medical images is essential. The data set for fundus data manipulation used 356 right fundus images of 4 lesions (normal, diabetic retinopathy, glaucoma, macular degeneration) out of about 6,000 data collected by Shangong Medical Technology Co., Ltd. The training and verification dataset of the manipulation detection model used original data and U-Net manipulation data. In addition, data manipulated in the Cycle General Adversaria
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45

Wahyu, Widiantara Fauzi, Daryati Daryati, and Saleh Rosmawita. "Penerapan Model Pembelajaran Flipped Classroom pada Mata Pelajaran Dasar-Dasar Konstruksi Bangunan dan Teknik Pengukuran Tanah." Indonesian Journal Of Civil Engineering Education 8, no. 2 (2023): 82. http://dx.doi.org/10.20961/ijcee.v8i2.70885.

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&lt;p dir="ltr"&gt;&lt;span&gt;Abstrak:&lt;/span&gt;&lt;span&gt;Penelitian ini bertujuan untuk mengetahui efektivitas dengan cara penerapan &lt;/span&gt;&lt;span&gt;flipped classroom&lt;/span&gt;&lt;span&gt; dalam mata pelajaran Dasar-Dasar Konstruksi dan Properti. Metode penelitian yang digunakan dalam penelitian ini adalah &lt;/span&gt;&lt;span&gt;quasi experimental &lt;/span&gt;&lt;span&gt;dengan bentuk &lt;/span&gt;&lt;span&gt;randomized pretest-posttest control group design. &lt;/span&gt;&lt;span&gt;Pengumpulan data dilakukan dengan instrument &lt;/span&gt;&lt;span&gt;pretest dan posttest
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Abhay, Simone Shah, Dhanraj Ganapathy, Deepak Nallaswamy Veeraiyan, et al. "Wear Resistance, Color Stability and Displacement Resistance of Milled PEEK Crowns Compared to Zirconia Crowns under Stimulated Chewing and High-Performance Aging." Polymers 13, no. 21 (2021): 3761. http://dx.doi.org/10.3390/polym13213761.

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Recently, polyetheretherketone (PEEK) has been introduced to the dental market as a high-performance and chemically inert biomaterial. This study aimed to compare the wear resistance, abrasiveness, color stability, and displacement resistance of zirconia and PEEK milled crowns. An ideal tooth preparation of a first maxillary molar was done and scanned by an intraoral scanner to make a digital model. Then, the prosthetic crown was digitally designed on the CAD software, and the STL file was milled in zirconia (CaroZiir S, Carol Zircolite Pvt. Ltd., Gujarat, India) and PEEK (BioHpp, Bredent GmbH
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47

Chechliński, Łukasz, Barbara Siemiątkowska, and Michał Majewski. "A System for Weeds and Crops Identification—Reaching over 10 FPS on Raspberry Pi with the Usage of MobileNets, DenseNet and Custom Modifications." Sensors 19, no. 17 (2019): 3787. http://dx.doi.org/10.3390/s19173787.

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Automated weeding is an important research area in agrorobotics. Weeds can be removed mechanically or with the precise usage of herbicides. Deep Learning techniques achieved state of the art results in many computer vision tasks, however their deployment on low-cost mobile computers is still challenging. The described system contains several novelties, compared both with its previous version and related work. It is a part of a project of the automatic weeding machine, developed by the Warsaw University of Technology and MCMS Warka Ltd. Obtained models reach satisfying accuracy (detecting 47–67
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48

Chen, Jo‐Lin, Tsung‐Che Chiang, and Po‐Tsun Liu. "All‐Metal‐Oxide Heterojunction Optoelectronic Synapses with Multilevel Memory for Artificial Visual Perception Applications." Small, May 2, 2025. https://doi.org/10.1002/smll.202502271.

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AbstractMetal‐oxide semiconductor‐based optoelectronic synaptic transistors have attracted considerable attention due to their high energy efficiency and stability. This work proposes a novel WO3/InWZnO heterojunction optoelectronic synaptic transistor, demonstrating the strong potential for emulating the human visual system. The fabricated heterojunction synaptic transistor achieves an impressive optical responsivity of 58.37 A W−1 when exposed to 650 nm light. Furthermore, it successfully emulates transitions from short‐term memory (STM) to long‐term memory (LTM) by modulating pulse duration
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49

Fleming, Derek, and Robin Patel. "P-647. Comparative efficacy of antibiotic regimens against Ureaplasma species with varying antibiotic resistance profiles in a mouse model of lung infection." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.844.

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Abstract Background Lung transplant recipients (LTRs) can experience hyperammonemia syndrome (HS) correlated with lung infection by ammonia-producing Ureaplasma species. HS in LTRs can be managed by Ureaplasma-directed antibiotic therapy; however, Ureaplasma species lack a cell wall, limiting treatment options. Precise guidelines for Ureaplasma-directed antibiotic therapy in LTRs is lacking, and antibiotic resistance may complicate treatment. Here, levofloxacin (LEV), azithromycin (AZM), and doxycycline (DOX) were tested against isolates of U. urealyticum and U. parvum with varying antibiotic
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50

Feng, Wanzhe, and Kai-Yu Zhang. "Explaining W boson mass anomaly and dark matter with a U(1) dark sector." Chinese Physics C, November 24, 2022. http://dx.doi.org/10.1088/1674-1137/aca585.

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Abstract The $W$ boson mass recently reported by the CDF collaboration shows a deviation from the standard model prediction with an excess at $7\sigma$ level. We investigate two simple extensions of the standard model with an extra $U(1)$ dark sector. One is the $U(1)_x$ extension, where the $U(1)_x$ gauge field mixes with the standard model through gauge kinetic terms. The other is a general $U(1)_{\alpha Y+\beta q}$ extension of the standard model. Fitting various experimental constraints we find the $U(1)_x$ extension with only kinetic mixing can enhance the $W$ boson mass for at most 10~Me
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