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1

Weiss, Elizabeth C., Agnieszka Zielinska, Karen E. Beenken, Horace J. Spencer, Sonja J. Daily, and Mark S. Smeltzer. "Impact of sarA on Daptomycin Susceptibility of Staphylococcus aureus Biofilms In Vivo." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4096–102. http://dx.doi.org/10.1128/aac.00484-09.

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ABSTRACT We used a murine model of catheter-associated biofilm formation to determine whether the mutation of the staphylococcal accessory regulator (sarA) has an impact on the susceptibility of established Staphylococcus aureus biofilms to treatment with daptomycin in vivo. The experiments were done with two clinical isolates, one of which (UAMS-1) was obtained from the bone of a patient suffering from osteomyelitis, while the other (UAMS-1625) is an isolate of the USA300 clonal lineage of community-acquired methicillin (meticillin)-resistant S. aureus. UAMS-1625 had a reduced capacity to for
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Cassat, James E., Paul M. Dunman, Fionnuala McAleese, Ellen Murphy, Steven J. Projan, and Mark S. Smeltzer. "Comparative Genomics of Staphylococcus aureus Musculoskeletal Isolates." Journal of Bacteriology 187, no. 2 (2005): 576–92. http://dx.doi.org/10.1128/jb.187.2.576-592.2005.

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ABSTRACT Much of the research aimed at defining the pathogenesis of Staphylococcus aureus has been done with a limited number of strains, most notably the 8325-4 derivative RN6390. Several lines of evidence indicate that this strain is unique by comparison to clinical isolates of S. aureus. Based on this, we have focused our efforts on two clinical isolates (UAMS-1 and UAMS-601), both of which are hypervirulent in our animal models of musculoskeletal infection. In this study, we used comparative genomic hybridization to assess the genome content of these two isolates relative to RN6390 and eac
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Bitzi, Barbara, and Sara Landolt. "Unaccompanied minor asylum seekers – processes of subject formation and feelings of belonging in the context of educational experiences in Switzerland." Geographica Helvetica 72, no. 2 (2017): 217–26. http://dx.doi.org/10.5194/gh-72-217-2017.

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Abstract. This article addresses unaccompanied minor asylum seekers' (UAMs) educational experiences in Switzerland. Drawing on ethnographic research we explore what it means for UAMs to get an education and how having access or not having access to particular forms and spaces of education plays a part in the process of their subject formations. We get insights into such processes in diverse spaces of education and in phases of transition between them. We point out how educational arrangements can produce feelings of belonging and non-belonging and highlight that these feelings are entangled wi
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Uzureau, Océane, Ine Lietaert, Daniel Senovilla Hernández, and Ilse Derluyn. "Unaccompanied Adolescent Minors’ Experiences of Exception and Abandonment in the Ventimiglia Border Space." Politics and Governance 10, no. 2 (2022): 267–78. http://dx.doi.org/10.17645/pag.v10i2.5139.

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This article explores unaccompanied adolescent minors’ (UAMs) experiences of deterrent practices at internal EU borders while being on the move. Previous studies have acknowledged the securitisation of external borders through gatekeeping and fencing practices; however, there is a recent and continued renationalisation of internal EU borders by the member states. Like other migrants who are travelling irregularly, UAMs also often face harsh living conditions and repeated rights violations in border areas, regardless of their specific rights to protection and psychological needs. Research has c
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Clerc, Sélim. "Street-Level Workers and Unaccompanied Minors: Between Vulnerability and Suspicion." Swiss Journal of Sociology 48, no. 3 (2022): 571–92. http://dx.doi.org/10.2478/sjs-2022-0028.

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Abstract Focusing on practices and representations mobilized by street-level workers in the management of North African unaccompanied minor migrants (UAMs) in Geneva, I take a closer look at the everyday assessment and production of UAMs’ deservingness in the context of humanitarianism. I show the importance of doubt and of perceived vulnerability in the informal evaluation process of UAMs’ right for protection. I further demonstrate how the social construction of childhood, race, and gender influence street-level workers’ perceptions.
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Barn, Ravinder, Roberta Teresa Di Rosa, and Theano Kallinikaki. "Unaccompanied Minors in Greece and Italy: An Exploration of the Challenges for Social Work within Tighter Immigration and Resource Constraints in Pandemic Times." Social Sciences 10, no. 4 (2021): 134. http://dx.doi.org/10.3390/socsci10040134.

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The number of unaccompanied minors (UAMs) arriving in the European Union (EU) has been increasing dramatically over recent years resulting in the formulation of EU policy directives around safeguarding and well-being. Notably, the majority of UAMs enter Europe irregularly through two main gateways to the European continent: via Italy, using the Central Mediterranean Sea route; or through Greece, transiting through the Eastern Mediterranean route from Turkey, mostly via sea. Profiles of UAMs travelling via the two different routes are significantly diverse, reflecting Italy’s and Greece’s geogr
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Clarke, Brett M., Jennings Boyette, Emre Vural, James Y. Suen, Elias J. Anaissie, and Brendan C. Stack. "Bisphosphonates and jaw osteonecrosis: The UAMS experience." Otolaryngology–Head and Neck Surgery 136, no. 3 (2007): 396–400. http://dx.doi.org/10.1016/j.otohns.2006.11.008.

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Valtolina, Giovanni Giulio, and Marina D’Odorico. "Crossing alone the Mediterranean sea. Some critical issues about unaccompanied minors in Europe." REMHU: Revista Interdisciplinar da Mobilidade Humana 25, no. 51 (2017): 77–94. http://dx.doi.org/10.1590/1980-85852503880005106.

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Abstract Despite the increasing social impact of unaccompanied migrant minors (UAMs) in many European Union (EU) member states, EU regulations on UAMs are still inadequate and the necessary protection measures are thus insufficient. More specifically, the “best interest of the child”, stated in a large number of international documents, may not be properly guaranteed. In addition, there is often a discrepancy between the rights of migrant children, according to the international legislation, and the actual protection they receive. Moreover, despite the declared aim of reaching a common standar
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9

McSweeney, Jean, David Robinson, Anthony McGuire, et al. "2025." Journal of Clinical and Translational Science 1, S1 (2017): 67–68. http://dx.doi.org/10.1017/cts.2017.240.

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OBJECTIVES/SPECIFIC AIMS: To establish a state-wide research registry of diverse participants. METHODS/STUDY POPULATION: We garnered broad institutional and community support by involving TRI’s Community Engagement team, its Community Advisory Board (CAB), and 3 UAMS patient CABs in selecting Web site content, images, and colors. Using this feedback, the TRI Recruitment Unit (RU), in conjunction with UAMS Communications and the Center for Health Literacy, developed the materials and crafted comprehensive communication and recruitment strategies. The UAMS Center for Pacific Islander Health, His
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10

Cassat, James, Paul M. Dunman, Ellen Murphy, et al. "Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390." Microbiology 152, no. 10 (2006): 3075–90. http://dx.doi.org/10.1099/mic.0.29033-0.

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The production of Staphylococcus aureus virulence factors is under the control of complex regulatory circuits. Most studies aimed at defining these regulatory networks have focused on derivatives of the strain NCTC 8325, most notably RN6390. However, all NCTC 8325 derivatives, including RN6390, possess an 11 bp deletion in rsbU. This deletion renders NCTC 8325 derivatives naturally sigma-factor-B deficient. Recent studies have shown that RN6390 is also deficient, in comparison to clinical isolates, with respect to biofilm formation, a process which is important for both pathogenesis and antimi
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Hoang, Van Trung, Hoang Anh Thi Van, Cong Thao Trinh, et al. "Uterine Arteriovenous Malformation: A Pictorial Review of Diagnosis and Management." Journal of Endovascular Therapy 28, no. 5 (2021): 659–75. http://dx.doi.org/10.1177/15266028211025022.

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Uterine arteriovenous malformation (UAVM) is a rare condition and is classified as either congenital or acquired UAVM. Patients with UAVMs usually experience miscarriages or recurrent menorrhagia. Ultrasound is used for the initial estimation of UAVMs. Computed tomography and magnetic resonance imaging are noninvasive and valuable methods that provide good compatibility with digital subtraction angiography to support the diagnosis and treatment of UAVM. Timely diagnosis is crucial to provide appropriate treatment for alleviating complications. This article presents a pictorial and literature r
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12

Pasquale, Gianna. "Unaccompanied foreign minors in Italy between normative and educational needs." New Trends and Issues Proceedings on Humanities and Social Sciences 5, no. 1 (2018): 90–106. http://dx.doi.org/10.18844/prosoc.v5i1.3390.

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 Nowadays, unaccompanied foreign minors (UAMs) are a significant part of the migrants who arrive in Italy. Starting from the statistical analysis concerning the presence of UAMs in Italy, this paper aims to examine this complex phenomenon and to investigate the legal and socio-educational issues regarding this vulnerable group of migrants.Recently, Italian government has shown a particular interest in the protection of these children who arrive in Italy, approving the Law No. 47 of 7 April 2017 on ‘Provisions on Protective Measures for UAMs’. This law has amended the existi
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Papanikolaou, Xenofon, Sarah Waheed, Bart Barlogie, et al. "Waldenstrom's Macroglobulinemia Associated Bone Disease the UAMS Experience." Blood 124, no. 21 (2014): 2999. http://dx.doi.org/10.1182/blood.v124.21.2999.2999.

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Abstract Introduction: Bone disease in patients with paraproteinemias is typically associated to a diagnosis of of multiple myeloma (MM) and the presence of an IgM monoclonal gammopathy with associated lytic bone abnormalities always suggests the possibility of an IgM MM. Because Waldestrom’s Macroglobulinemia (WM) with lytic bone disease has also been reported in the literature we decided to retrospectively investigate the incidence of bone disease in patients carrying a diagnosis of WM and to evaluate the clinical relevant associations. Methods: After receiving IRB approvalwe retrospectively
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14

Weiss, Elizabeth C., Horace J. Spencer, Sonja J. Daily, Brian D. Weiss, and Mark S. Smeltzer. "Impact of sarA on Antibiotic Susceptibility of Staphylococcus aureus in a Catheter-Associated In Vitro Model of Biofilm Formation." Antimicrobial Agents and Chemotherapy 53, no. 6 (2009): 2475–82. http://dx.doi.org/10.1128/aac.01432-08.

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ABSTRACT Mutation of the staphylococcal accessory regulator (sarA) in Staphylococcus aureus limits but does not abolish the capacity of the organism to form a biofilm. As a first step toward determining whether this limitation is therapeutically relevant, we carried out in vitro studies comparing the relative susceptibility of an S. aureus clinical isolate (UAMS-1) and its isogenic sarA mutant (UAMS-929) in the specific context of a catheter-associated biofilm. The antibiotics tested were daptomycin, linezolid, and vancomycin, all of which were evaluated by using concentrations based on the MI
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Doğramacı, Münevver, Greta G. Gramig, James V. Anderson, Wun S. Chao, and Michael E. Foley. "Field Application of Glyphosate Induces Molecular Changes Affecting Vegetative Growth Processes in Leafy Spurge (Euphorbia esula)." Weed Science 64, no. 1 (2016): 87–100. http://dx.doi.org/10.1614/ws-d-15-00108.1.

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Recommended rates of glyphosate for noncultivated areas destroy the aboveground shoots of the perennial plant leafy spurge. However, such applications cause little or no damage to underground adventitious buds (UABs), and thus the plant readily regenerates vegetatively. High concentrations of glyphosate, applied under controlled environmental conditions, have been shown to cause sublethal effects in UABs of leafy spurge that produce stunted and bushy phenotypes in subsequent generations of shoots. We treated leafy spurge plants in the field with glyphosate (0, 1.1, 3.4, or 6.7 kg ai ha−1) to d
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Kumbhar, Abhaykumar. "Performance Improvement Using ICIC for UAV-Assisted Public Safety Networks with Clustered Users during Emergency." Telecom 4, no. 4 (2023): 816–35. http://dx.doi.org/10.3390/telecom4040036.

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The application of drones, also known as unmanned aerial vehicles deployed as unmanned aerial base stations (UABSs), has received extensive interest for public safety communications (PSC) to fill the coverage gaps and establish ubiquitous connectivity. In this article, we design a PSC LTE-Advanced air–ground-based HetNet (AG-HetNet) that is a scenario representation of a geographical area during and after a disaster. As part of the AG-HetNet infrastructure, we have UABSs and ground user equipment (GUE) flocking together in clusters at safe places or evacuation shelters. AG-HetNet uses cell ran
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Penaherrera, Daniel, Sheri Skerget, Austin Christofferson, et al. "Development and Validation of a High Risk Multiple Myeloma Gene Expression Index from RNA Sequencing: An Mmrf Commpass Analysis." Blood 132, Supplement 1 (2018): 1895. http://dx.doi.org/10.1182/blood-2018-99-119610.

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Abstract Multiple Myeloma (MM) is a genetically heterogeneous disease of plasma cells that generally exhibits chromosomal abnormalities and distinct gene expression signatures. Previous studies have sought to identify gene expression indices using microarray technology to discern genes associated with survival outcomes to predict whether a newly diagnosed patient has an aggressive form of the disease. One such MM-specific index is the UAMS 70 gene index, which is composed of 51 over- and 19 under-expressed genes. This index was developed using Affymetrix U133Plus2.0 microarray data from 532 MM
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Cue, David, Mei G. Lei, Thanh T. Luong, et al. "Rbf Promotes Biofilm Formation by Staphylococcus aureus via Repression of icaR, a Negative Regulator of icaADBC." Journal of Bacteriology 191, no. 20 (2009): 6363–73. http://dx.doi.org/10.1128/jb.00913-09.

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ABSTRACT We previously reported the identification of a gene, rbf, involved in the regulation of biofilm formation by Staphylococcus aureus 8325-4. In an effort to study the mechanism of regulation, microarrays were used to compare the transcription profiles of the wild-type strain with an rbf mutant and an rbf overexpression strain of the clinical isolate UAMS-1. Among the genes affected by rbf overexpression are those of the intercellular adhesion (ica) locus; however, expression of these genes was not affected by an rbf deletion in the chromosome. The icaADBC genes are responsible for produ
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Johannsen, Neil M., and Rick L. Sharp. "Effect of Preexercise Ingestion of Modified Cornstarch on Substrate Oxidation during Endurance Exercise." International Journal of Sport Nutrition and Exercise Metabolism 17, no. 3 (2007): 232–43. http://dx.doi.org/10.1123/ijsnem.17.3.232.

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The purpose of this study was to investigate differences in substrate oxidation between dextrose (DEX) and unmodified (UAMS) and acid/alcohol-modified (MAMS) cornstarches. Seven endurance-trained men (VO2peak = 59.1 ± 5.4 mL·kg−1·min−1) participated in 2 h of exercise (66.4% ± 3.3% VO2peak) 30 min after ingesting 1 g/kg body weight of the experimental carbohydrate or placebo (PLA). Plasma glucose and insulin were elevated after DEX (P < 0.05) compared with UAMS, MAMS, and PLA. Although MAMS and DEX raised carbohydrate oxidation rate through 90 min of exercise, only MAMS persisted throughout
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Luong, Thanh T., Mei G. Lei, and Chia Y. Lee. "Staphylococcus aureus Rbf Activates Biofilm Formation In Vitro and Promotes Virulence in a Murine Foreign Body Infection Model." Infection and Immunity 77, no. 1 (2008): 335–40. http://dx.doi.org/10.1128/iai.00872-08.

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ABSTRACT We previously identified Rbf as an activator for biofilm formation on polystyrene surfaces in Staphylococcus aureus strain 8325-4. However, strain 8325-4 contains genetic mutations that may affect biofilm formation. To extend the observation to other strains, we used strain Newman, a weak biofilm producer, and strain UAMS-1, an osteomyelitis clinical strain, in this study. We found that mutations in the chromosomal rbf gene did not affect biofilm formation on polystyrene surfaces in these strains, but transformants of these strains carrying a multiple-copy plasmid containing the rbf g
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Hermenegildo, Jorge L. S., Marialice Moraes, Jaqueline Rossato, and Eleonora Milano Falcão Vieira. "UAB’s Reflex on Cities and Local Support Centers to Distance Education." International Journal of Recent Contributions from Engineering, Science & IT (iJES) 2, no. 2 (2014): 13. http://dx.doi.org/10.3991/ijes.v2i2.3813.

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Licona Angeles, Jessica, Francisco Rubén Castañeda Rivero, and María A. Mendoza-Becerril. "Community Composition of Epibiont Hydroids of the Naturalized Alien Macroalga Acanthophora spicifera in Pichilingue, Mexico." Biology 14, no. 1 (2025): 44. https://doi.org/10.3390/biology14010044.

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This study provides a detailed analysis of the community of hydrozoan epibionts of Acanthophora spicifera in La Paz Bay, Baja California Sur. The investigation was carried out in two season periods, corresponding to the warm and cold seasons on the pier of the Autonomous University of Baja California Sur (UABCS) Pichilingue research station. The percentage of epibiont coverage was calculated and analyzed. The average length of the thalli was 7.8 ± 4.6 cm. Eleven taxa of hydrozoans were recorded; the hydrozoan Obelia cf. dichotoma had the highest coverage percentage, and in summer, there was a
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López González, José Luis. "ZAPATER ESPÍ, Luis Tomás (2022). Teoría del Estado: desde el origen a la globalización. La Paz, México: Ed. Universidad Autónoma de Baja California Sur (UABCS)." Asamblea. Revista parlamentaria de la Asamblea de Madrid, no. 45 (December 29, 2023): 375–83. http://dx.doi.org/10.59991/rvam/2023/n.45/491.

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Atwood, Danielle N., Karen E. Beenken, Allister J. Loughran, et al. "XerC Contributes to Diverse Forms of Staphylococcus aureus Infection viaagr-Dependent andagr-Independent Pathways." Infection and Immunity 84, no. 4 (2016): 1214–25. http://dx.doi.org/10.1128/iai.01462-15.

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We demonstrate that mutation ofxerC, which reportedly encodes a homologue of anEscherichia colirecombinase, limits biofilm formation in the methicillin-resistantStaphylococcus aureusstrain LAC and the methicillin-sensitive strain UAMS-1. This was not due to the decreased production of the polysaccharide intracellular adhesin (PIA) in either strain because the amount of PIA was increased in a UAMS-1xerCmutant and undetectable in both LAC and its isogenicxerCmutant. Mutation ofxerCalso resulted in the increased production of extracellular proteases and nucleases in both LAC and UAMS-1, and limit
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Meeker, Daniel G., Karen E. Beenken, Weston B. Mills, et al. "Evaluation of Antibiotics Active against Methicillin-Resistant Staphylococcus aureus Based on Activity in an Established Biofilm." Antimicrobial Agents and Chemotherapy 60, no. 10 (2016): 5688–94. http://dx.doi.org/10.1128/aac.01251-16.

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ABSTRACTWe usedin vitroandin vivomodels of catheter-associated biofilm formation to compare the relative activity of antibiotics effective against methicillin-resistantStaphylococcus aureus(MRSA) in the specific context of an established biofilm. The results demonstrated that, underin vitroconditions, daptomycin and ceftaroline exhibited comparable activity relative to each other and greater activity than vancomycin, telavancin, oritavancin, dalbavancin, or tigecycline. This was true when assessed using established biofilms formed by the USA300 methicillin-resistant strain LAC and the USA200 m
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Moutsou, Irene, Eugenie Georgaca, and Theofilos Varaklis. "Psychotherapeutic and Psychosocial Interventions with Unaccompanied Minors: A Scoping Review." Healthcare 11, no. 6 (2023): 918. http://dx.doi.org/10.3390/healthcare11060918.

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Unaccompanied minors (UAMs) are considered a particularly vulnerable population, facing severe threats regarding their physical and mental health. As their number has increased in recent years worldwide, research on mental health interventions has become necessary. The implementation of psychotherapeutic interventions has been documented, but psychosocial interventions seem to not have been consistently studied. In this review, we summarize the psychotherapeutic and psychosocial interventions with UAMs that have been studied up to now. Following the PRISMA guidelines for scoping reviews, we se
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Patseadou, Magdalini, Catherine Chamay Weber, and Dagmar M. Haller. "Health status and healthcare services utilisation among unaccompanied asylum-seeking minors settled in Switzerland: a protocol for a retrospective cohort study from a hospital-based youth outpatient clinic." BMJ Open 12, no. 3 (2022): e056276. http://dx.doi.org/10.1136/bmjopen-2021-056276.

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IntroductionUnaccompanied asylum-seeking minors (UASMs) represent a population group with complex healthcare needs. Initial and ongoing healthcare is challenging for host countries but considered essential. This publication describes the protocol concerning a large cohort of UASMs settled in Switzerland in 2015–2016. Our aim is to assess their health status and examine their trajectories of healthcare services utilisation during the 3-year period after their initial health control.Methods and analysisWe will retrospectively analyse data of all newly arrived UASMs aged 12–18 years who benefited
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Zhang, Qing, Christoph Heuck, Pingping Qu, et al. "Gene Expression Profiling-Based Risk Stratification Scores In Multiple Myeloma Can Be Highly Sensitive Towards Sample Preparation." Blood 122, no. 21 (2013): 1865. http://dx.doi.org/10.1182/blood.v122.21.1865.1865.

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Abstract Background Gene expression profiling (GEP) via microarray analysis enables the measurement of expression levels for tens of thousands of genes in a single experiment, and it has been widely used in clinical practice for cancer classification, risk stratification, and treatment selection. However, results of GEP-based clinical diagnostic/prognostic tests can be highly affected by batch effects when clinical samples are processed differently (e.g. on different days, by different technicians, or using different sample protocols). Yet, this problem is rarely discussed in the literature. U
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Li, Zhe, Wenhui Chen, and Weijie Wang. "UAMS: An Unsupervised Anomaly Detection Method Integrating MSAA and SSPCAB." Symmetry 17, no. 7 (2025): 1119. https://doi.org/10.3390/sym17071119.

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Anomaly detection methods play a crucial role in automated quality control within modern manufacturing systems. In this context, unsupervised methods are increasingly favored due to their independence from large-scale labeled datasets. However, existing methods present limited multi-scale feature extraction ability and may fail to effectively capture subtle anomalies. To address these challenges, we propose UAMS, a pyramid-structured normalization flow framework that leverages the symmetry in feature recombination to harmonize multi-scale interactions. The proposed framework integrates a Multi
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Loughran, Allister J., Dana Gaddy, Karen E. Beenken, et al. "Impact ofsarAand Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus." Infection and Immunity 84, no. 9 (2016): 2586–94. http://dx.doi.org/10.1128/iai.00152-16.

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We used a murine model of acute, posttraumatic osteomyelitis to evaluate the virulence of two divergentStaphylococcus aureusclinical isolates (the USA300 strain LAC and the USA200 strain UAMS-1) and their isogenicsarAmutants. The results confirmed that both strains caused comparable degrees of osteolysis and reactive new bone formation in the acute phase of osteomyelitis. Conditioned medium (CM) from stationary-phase cultures of both strains was cytotoxic to cells of established cell lines (MC3TC-E1 and RAW 264.7 cells), primary murine calvarial osteoblasts, and bone marrow-derived osteoclasts
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Kuiper, Rowan, Martin van Vliet, Annemiek Broyl, et al. "Comparison Of Conventional, FISH and GEP Prognostic Factors In Multiple Myeloma: Introducing a Novel Risk Stratification." Blood 122, no. 21 (2013): 3092. http://dx.doi.org/10.1182/blood.v122.21.3092.3092.

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Abstract Introduction Multiple Myeloma (MM) is a heterogeneous disease with highly variable survival. Gene expression profiling (GEP) classifiers, such as the EMC-92, can consistently distinguish high risk patients from standard risk patients. Other prognostic factors for MM include the international staging system (ISS) and FISH. Here we present a comparison of prognostic factors and introduce a novel stratification based on EMC-92 and ISS. Methods Scores were calculated for the GEP classifiers EMC-92, UAMS-70, UAMS-17, UAMS-80 and MRC-IX-6 for the following five studies: HOVON-65/GMMG-HD4 (n
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Vuk, Jasna, Steven McKee, Sara Tariq, and Priya Mendiratta. "A Better Learning Community: Mixed-Methods Reveal Medical Student Preferences with Implications for Learning Community Design and Implementation." Journal of Medical Education and Curricular Development 8 (January 2021): 238212052110148. http://dx.doi.org/10.1177/23821205211014895.

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Background: Medical school learning communities benefit students. The College of Medicine (COM) at the University of Arkansas for Medical Sciences (UAMS) provides medical students with academic, professional, and personal support through a learning community (LC) made of 7 academic houses. Objectives: To evaluate the effectiveness of the academic house model at UAMS utilizing a mixed-methods survey. The aims were to: (1) assess student experience and satisfaction with academic houses, (2) describe the realms of advising and guidance, and (3) identify areas for improvement. Method: An online su
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Beenken, Karen E., Paul M. Dunman, Fionnuala McAleese, et al. "Global Gene Expression in Staphylococcus aureus Biofilms." Journal of Bacteriology 186, no. 14 (2004): 4665–84. http://dx.doi.org/10.1128/jb.186.14.4665-4684.2004.

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ABSTRACT We previously demonstrated that mutation of the staphylococcal accessory regulator (sarA) in a clinical isolate of Staphylococcus aureus (UAMS-1) results in an impaired capacity to form a biofilm in vitro (K. E. Beenken, J. S. Blevins, and M. S. Smeltzer, Infect. Immun. 71:4206-4211, 2003). In this report, we used a murine model of catheter-based biofilm formation to demonstrate that a UAMS-1 sarA mutant also has a reduced capacity to form a biofilm in vivo. Surprisingly, mutation of the UAMS-1 ica locus had little impact on biofilm formation in vitro or in vivo. In an effort to ident
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Beenken, Karen E., Jon S. Blevins, and Mark S. Smeltzer. "Mutation of sarA in Staphylococcus aureus Limits Biofilm Formation." Infection and Immunity 71, no. 7 (2003): 4206–11. http://dx.doi.org/10.1128/iai.71.7.4206-4211.2003.

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ABSTRACT Mutation of sarA resulted in a reduced capacity to form a biofilm in six of the eight Staphylococcus aureus strains we tested (UAMS-1, UAMS-601, SA113, SC-01, S6C, and DB). The exceptions were Newman, which formed a poor biofilm under all conditions, and RN6390, which consistently formed a biofilm only after mutation of agr. Mutation of agr in other strains had little impact on biofilm formation. In every strain other than Newman, including RN6390, simultaneous mutation of sarA and agr resulted in a phenotype like that observed with the sarA mutants. Complementation studies using a sa
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Huang, Wei-Chun, Cheng-Yen Tsai, and Eric Chieh-Lung Chou. "An Alternative Approach for Treating Female Underactive Bladders with Chronic Urine Retention: A Pilot Study on Combined Transvaginal Ultrasound-Guided Botulinum Toxin A External Sphincter Injection and Transurethral Incision of the Bladder Neck." Toxins 16, no. 10 (2024): 441. http://dx.doi.org/10.3390/toxins16100441.

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Background: Treating an underactive bladder (UAB) is challenging. Previously, we introduced a more precise method of transvaginal ultrasound-guided botulinum toxin A (BoNT-A) injection into the external urethral sphincter as a treatment option for patients with UABs. Although many patients experience good results, those with an UAB and excessive residual urine still require catheterization. Therefore, we developed a new method that combines transvaginal ultrasound-guided BoNT-A injection with a transurethral bladder neck incision. Methods: A prospective study was conducted on 16 patients who e
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Walden, Anita, Aaron S. Kemp, Linda J. Larson-Prior, et al. "Establishing a digital health platform in an academic medical center supporting rural communities." Journal of Clinical and Translational Science 4, no. 5 (2020): 384–88. http://dx.doi.org/10.1017/cts.2020.11.

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AbstractThe University of Arkansas for Medical Sciences (UAMS), like many rural states, faces clinical and research obstacles to which digital innovation is seen as a promising solution. To implement digital technology, a mobile health interest group was established to lay the foundation for an enterprise-wide digital health innovation platform. To create a foundation, an interprofessional team was established, and a series of formal networking events was conducted. Three online digital health training models were developed, and a full-day regional conference was held featuring nationally reco
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Broyl, Annemiek, Dirk Hose, Henk Lokhorst, et al. "Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients." Blood 116, no. 14 (2010): 2543–53. http://dx.doi.org/10.1182/blood-2009-12-261032.

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Abstract To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters described in the University of Arkansas for Medical Science (UAMS) classification, CD-1 (n = 13, 4.1%), CD-2 (n = 34, 1.6%), MF (n = 32, 1.0%), MS (n = 33, 1.3%), proliferation-associated genes (n = 15, 4.7%), and hyperdiploid (n = 77, 24.1%). Moreover, the UAMS low percentage
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Coin, Francesca, and Monica Banzato. "A Case Study on the Impact of Digital Relationships on Unaccompanied Minors during the COVID-19 Lockdown." International Journal of Learning, Teaching and Educational Research 21, no. 11 (2022): 15–32. http://dx.doi.org/10.26803/ijlter.21.11.2.

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The exploratory study investigates how unaccompanied minors (UAMs) in Italy dealt with social isolation at the time of the outbreak of the COVID-19 pandemic. Have they suffered from the effects of the lockdown? How did their relationships change? What feelings characterised their experience? What factors helped them? Did ICT help them, or did it increase their social and economic marginalisation? Very little research has investigated the issues of UAMs, socialisation, technologies, and pandemics together. The data were collected through a purpose-built questionnaire that obtained an excellent
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Šiljeg, Ante, Lovre Panđa, Fran Domazetović, et al. "Comparative Assessment of Pixel and Object-Based Approaches for Mapping of Olive Tree Crowns Based on UAV Multispectral Imagery." Remote Sensing 14, no. 3 (2022): 757. http://dx.doi.org/10.3390/rs14030757.

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Pixel-based (PB) and geographic-object-based (GEOBIA) classification approaches allow the extraction of different objects from multispectral images (MS). The primary goal of this research was the analysis of UAV imagery applicability and accuracy assessment of MLC and SVM classification algorithms within PB and GEOBIA classification approaches. The secondary goal was to use different accuracy assessment metrics to determine which of the two tested classification algorithms (SVM and MLC) most reliably distinguishes olive tree crowns and which approach is more accurate (PB or GEOBIA). The third
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Tsushima, Ikuo, Yuji Ogasawara, Masaki Shimokawa, Tomonori Kindaichi, and Satoshi Okabe. "Development of a super high-rate Anammox reactor and in situ analysis of biofilm structure and function." Water Science and Technology 55, no. 8-9 (2007): 9–17. http://dx.doi.org/10.2166/wst.2007.236.

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The anaerobic ammonium oxidation (Anammox) process is a new efficient and cost effective method of ammonium removal from wastewater. Under strictly anoxic condition, ammonium is directly oxidised with nitrite as electron acceptor to dinitrogen gas. However, it is extremely difficult to cultivate Anammox bacteria due to their low growth rate. This suggests that a rapid and efficient start-up of Anammox process is the key to practical applications. To screen appropriate seeding sludge with high Anammox potential, a real-time quantitative PCR assay with newly designed primers has been developed.
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Heikinheimo, K., J. M. Huhtala, A. Thiel, et al. "The Mutational Profile of Unicystic Ameloblastoma." Journal of Dental Research 98, no. 1 (2018): 54–60. http://dx.doi.org/10.1177/0022034518798810.

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BRAF V600E is the most common mutation in conventional ameloblastoma (AM) of the mandible. In contrast, maxillary AMs appear to harbor more frequently RAS, FGFR2, or SMO mutations. Unicystic ameloblastoma (UAM) is considered a less aggressive variant of ameloblastoma, amenable to more conservative treatment, and classified as a distinct entity. The aim of this study was to characterize the mutation profile of UAM ( n = 39) and to compare it to conventional AM ( n = 39). The associations between mutation status and recurrence probability were also analyzed. In the mandible, 94% of UAMs (29/31,
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Shaughnessy, John D., and Bart Barlogie. "Molecular Indicators of High-Risk Disease." Blood 112, no. 11 (2008): sci—6—sci—6. http://dx.doi.org/10.1182/blood.v112.11.sci-6.sci-6.

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Abstract High-risk multiple myeloma (HRMM) is routinely defined by laboratory parameters alone or in combination in the Durie-Salmon and, more recently, the ISS staging systems. The Bartl grade, a cell morphology-based staging system, has seen limited use. The presence of abnormal cytogenetics, high BrdU labeling index, interphase FISH abnormalities, and flow cytometric measures have also been used. A molecular-based classification and risk stratification of MM may improve the definition of HRMM. Global gene expression profiling (GEP) with of CD138-selected plasma cells followed by unsupervise
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Maciel, Flávia Rodrigues. "DESAFIOS DO ESTUDO SUPERIOR A DISTÂNCIA NO BRASIL: UMA ANÁLISE DAS UABS." Minerva Magazine Science 1, no. 12 (2024): None. https://doi.org/10.31070/rm2024frm01.

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Blevins, Jon S., Karen E. Beenken, Mohamed O. Elasri, Barry K. Hurlburt, and Mark S. Smeltzer. "Strain-Dependent Differences in the Regulatory Roles of sarA and agr in Staphylococcus aureus." Infection and Immunity 70, no. 2 (2002): 470–80. http://dx.doi.org/10.1128/iai.70.2.470-480.2002.

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ABSTRACT The accessory gene regulator (agr) and the staphylococcal accessory regulator (sar) are central regulatory elements that control the production of Staphylococcus aureus virulence factors. To date, the functions of these loci have been defined almost exclusively using RN6390, which is representative of the laboratory strain 8325-4. However, RN6390 was recently shown to have a mutation in rsbU that results in a phenotype resembling that of a sigB mutant (I. Kullik et al., J. Bacteriol. 180:4814–4820, 1998). For that reason, it remains unclear whether the regulatory events defined in RN6
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Vaduva, Constantin-Cristian, Laurentiu Dira, Sidonia Maria Sandulescu, et al. "Case Report of Placenta Accreta Spectrum and Arteriovenous Malformations with Successful Preservation of Fertility After Birth." Diagnostics 14, no. 22 (2024): 2538. http://dx.doi.org/10.3390/diagnostics14222538.

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Uterine arteriovenous malformations (UAVMs) that occur after birth are a rare cause of late postpartum hemorrhage. Acquired UAVMs usually occur in conjunction with pathology of the placenta. In the spectrum of placenta accreta (PAS), subinvolution of the placental bed plays an important role in its pathophysiology. We present a case of UAVM in a pregnant woman with PAS who presented with marked metrorrhagia after delivery, which was treated with classical management. Then, 35 days later, she presented to the emergency room with severe metrorrhagia. As it was suspected that she had placental re
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Xu, Xiang, Wei Liu, and Guojun Xu. "A Time-Domain Wavenumber Integration Model for Underwater Acoustics Based on the High-Order Finite Difference Method." Journal of Marine Science and Engineering 12, no. 5 (2024): 728. http://dx.doi.org/10.3390/jmse12050728.

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Simulating the acoustic field excited by pulse sound sources holds significant practical value in computational ocean acoustics. Two primary methods exist for modeling underwater acoustic propagation in the time domain: the Fourier synthesis technique based on frequency decomposition and the time-domain underwater acoustic propagation model (TD-UAPM). TD-UAPMs solve the wave equation in the time domain without requiring frequency decomposition, providing a more intuitive explanation of the physical process of sound energy propagation over time. However, time-stepping numerical methods can accu
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Ding, Li, Tian Xia, Rui Ma, Dong Liang, Mingyue Lu, and Hongtao Wu. "Enhanced Impedance Control of Cable-Driven Unmanned Aerial Manipulators Using Fractional-Order Nonsingular Terminal Sliding Mode Control with Disturbance Observer Integration." Fractal and Fractional 8, no. 10 (2024): 579. http://dx.doi.org/10.3390/fractalfract8100579.

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The article presents a novel control strategy for cable-driven aerial manipulators (UAMs) aimed at enhancing impedance control during contact operations in complex environments. A fractional-order nonsingular terminal sliding mode control (FONTSMC) integrated with a disturbance observer (DOB) is proposed to improve the robustness and precision of the UAM under lumped disturbances. This developed approach utilizes the flexibility of fractional calculus, the finite-time stability of nonsingular terminal sliding mode, and the real-time disturbance estimation capabilities of the DOB to ensure smoo
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Suen, James Y., Lisa M. Buckmiller, Chun-Yang Fan, Gal Shafirstein, and Robert Glade. "Natural History of Arteriovenous Malformations." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P41—P42. http://dx.doi.org/10.1016/j.otohns.2008.05.136.

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Objective 1) To demonstrate the natural history of arteriovenous malformation (AVMs) when left untreated or inadequately managed. 2) To demonstrate the need for major treatment to patients, families, healthcare providers, and insurance companies. Methods Records from 10 of 50 representative patients treated at University of Arkansas for Medical Sciences (UAMS) for advanced AVMs were reviewed for age at presentation, gender, presenting symptoms, previous treatment, disease course, and post-presentation management. Patients were asked if quality of life had improved after treatment at UAMS Facia
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Park, Chanhong, Alex Ramirez-Serrano, and Mahdis Bisheban. "Adaptive Incremental Nonlinear Dynamic Inversion Control for Aerial Manipulators." Aerospace 11, no. 8 (2024): 671. http://dx.doi.org/10.3390/aerospace11080671.

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This paper proposes an adaptive incremental nonlinear dynamic inversion (INDI) controller for unmanned aerial manipulators (UAMs). A novel adaptive law is employed to enable aerial manipulators to manage the inertia parameter changes that occur when the manipulator moves or picks up unknown objects during any phase of the UAM’s flight maneuver. The adaptive law utilizes a Kalman filter to estimate a set of weighting factors employed to adjust the control gain matrix of a previously developed INDI control law formulated for the corresponding UAV (no manipulator included). The proposed adaptive
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Samah, Riache, Kidouche Madjid, and Rezoug Amar. "Adaptive robust nonsingular terminal sliding mode design controller for quadrotor aerial manipulator." TELKOMNIKA Telecommunication, Computing, Electronics and Control 17, no. 3 (2019): 1501–12. https://doi.org/10.12928/TELKOMNIKA.v17i3.10470.

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In this paper, a novel adaptive control approach for Unmanned Aerial Manipulators (UAMs) is proposed. The UAMs are a new configuration of the Unmanned Arial Vehicles (UAVs) which are characterized by several inhered nonlinearities, uncertainties and coupling. The studied UAM is a Quadrotor endowed with two degrees of freedom robotic arm. The main objectives of our contribution are to achieve both a tracking error convergence by avoiding any singularity problem and also the chattering amplitude attenuation in the presence of perturbations. Therefore, the proposed Adaptive Nonsingular Terminal S
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