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Journal articles on the topic 'UCASD'

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Published: 4 June 2021
Last updated: 16 February 2022

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1

ROVNER, SOPHIE. "UCSD SELECTS FOX." Chemical & Engineering News 82, no. 16 (April 19, 2004): 9. http://dx.doi.org/10.1021/cen-v082n016.p009.

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2

Buchan, James. "Decoding UCAS figures." Nursing Standard 32, no. 23 (January 31, 2018): 30. http://dx.doi.org/10.7748/ns.32.23.30.s20.

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3

Friedkin, Morris, and William S. Allison. "Nate at UCSD." Analytical Biochemistry 161, no. 2 (March 1987): 243–44. http://dx.doi.org/10.1016/0003-2697(87)90447-7.

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4

Lanterna, Luigi A., Giovanni Tredici, Borislav D. Dimitrov, and Francesco Biroli. "Treatment of Unruptured Cerebral Aneurysms by Embolization with Guglielmi Detachable Coils: Case-fatality, Morbidity, and Effectiveness in Preventing Bleeding—A Systematic Review of the Literature." Neurosurgery 55, no. 4 (October 1, 2004): 767–78. http://dx.doi.org/10.1227/01.neu.0000137653.93173.1c.

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Abstract OBJECTIVE: Guglielmi detachable coils (GDCs) increasingly are being used to treat unruptured cerebral aneurysms (UCAs). We systematically reviewed the literature to assess the case-fatality and permanent morbidity rates of GDC embolization of UCAs and the postembolization bleeding rate. METHODS: Through a MEDLINE search of the English, Italian, and French literature from January 1990 through December 2002, we retrieved studies on GDC embolization of aneurysms and extracted data on UCAs. Inclusion criteria were: 1) attempted GDC embolization of at least five consecutive patients with UCAs, 2) reported percentage of at least either case-fatality or permanent morbidity rate or crude data allowing an independent calculation. When data on UCAs could not be characterized with certainty among data on other, different lesions, the study was rejected. RESULTS: We included 30 studies. One thousand three hundred seventy-nine patients were available for the calculation of the case-fatality rate, 794 for the permanent morbidity rate, and 703 for the bleeding rate. The case-fatality rate was 0.6% (95% confidence interval, 0.2–1%), the permanent morbidity rate was 7% (95% confidence interval, 5.3–8.7%), and the bleeding rate was 0.9% per year (95% confidence interval, 0.41–1.4%). Only incompletely coiled UCAs of 10 mm or more accounted for the bleeding events. Morbidity decreased from 8.6% to 4.5% (P < 0.05) when the midyear of study (average calendar year of treatment) was 1995 or later. CONCLUSION: GDC embolization of UCAs is relatively safe, and the outcome is progressively improving. Partial embolization of UCAs of 10 mm or more is unlikely to provide an acceptable protection. Most of the source publications suffer from methodological weaknesses. Prospective studies with longer follow-up periods are needed to definitively assess the effectiveness of GDCs on UCAs.
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5

Chun, Se-Hak, and Yong-Hwan Byun. "Success Factors of UCSD CONNECT as Business Incubator." Journal of Digital Convergence 13, no. 1 (January 28, 2015): 135–49. http://dx.doi.org/10.14400/jdc.2015.13.1.135.

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6

Mukerji, Chandra. "Joe Gusfield at UCSD." American Sociologist 48, no. 1 (July 7, 2016): 8–13. http://dx.doi.org/10.1007/s12108-016-9328-7.

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7

Ogdon, Will. "UCSD at Darmstadt 1988." Perspectives of New Music 27, no. 2 (1989): 300. http://dx.doi.org/10.2307/833421.

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8

Smith, Helen R., Zbigniew Ulanowski, Paul H. Kaye, Edwin Hirst, Warren Stanley, Richard Kaye, Andreas Wieser, et al. "The Universal Cloud and Aerosol Sounding System (UCASS): a low-cost miniature optical particle counter for use in dropsonde or balloon-borne sounding systems." Atmospheric Measurement Techniques 12, no. 12 (December 13, 2019): 6579–99. http://dx.doi.org/10.5194/amt-12-6579-2019.

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Abstract. A low-cost miniaturized particle counter has been developed by The University of Hertfordshire (UH) for the measurement of aerosol and droplet concentrations and size distributions. The Universal Cloud and Aerosol Sounding System (UCASS) is an optical particle counter (OPC), which uses wide-angle elastic light scattering for the high-precision sizing of fluid-borne particulates. The UCASS has up to 16 configurable size bins, capable of sizing particles in the range 0.4–40 µm in diameter. Unlike traditional particle counters, the UCASS is an open-geometry system that relies on an external air flow. Therefore, the instrument is suited for use as part of a dropsonde, balloon-borne sounding system, as part of an unmanned aerial vehicle (UAV), or on any measurement platform with a known air flow. Data can be logged autonomously using an on-board SD card, or the device can be interfaced with commercially available meteorological sondes to transmit data in real time. The device has been deployed on various research platforms to take measurements of both droplets and dry aerosol particles. Comparative results with co-located instrumentation in both laboratory and field settings show good agreement for the sizing and counting ability of the UCASS.
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9

Singh, Sandeep, Maurice W. J. de Ronde, Maayke G. M. Kok, Marcel AM Beijk, Robbert J. De Winter, Allard C. van der Wal, Brigitte M. Sondermeijer, Joost C. M. Meijers, Esther E. Creemers, and Sara-Joan Pinto-Sietsma. "MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability." Open Heart 7, no. 1 (June 2020): e001223. http://dx.doi.org/10.1136/openhrt-2019-001223.

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BackgroundIn this study, we discovered and validated candidate microRNA (miRNA) biomarkers for coronary artery disease (CAD).MethodCandidate tissue-derived miRNAs from atherosclerotic plaque material in patients with stable coronary artery disease (SCAD) (n=14) and unstable coronary artery disease (UCAD) (n=25) were discovered by qPCR-based arrays. We validated differentially expressed miRNAs, along with seven promising CAD-associated miRNAs from the literature, in the serum of two large cohorts (n=395 and n=1000) of patients with SCAD and UCAD and subclinical atherosclerosis (SubA) and controls, respectively.ResultFrom plaque materials (discovery phase), miR-125b-5p and miR-193b-3p were most upregulated in SCAD, whereas miR-223-3p and miR-142-3p were most upregulated in patients with UCAD. Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR-223-3p, miR-133a-3p, miR-146-3p and miR-155-5p. The ischaemia-related miR-499-5p was also highly upregulated in patients with UCAD compared with the other groups (SCAD OR 20.63 (95% CI 11.16 to 38.15), SubA OR 96.10 (95% CI 40.13 to 230.14) and controls OR 15.73 (95% CI 7.80 to 31.72)). However, no significant difference in miR-499-5p expression was observed across SCAD, SubA and controls. MiR-122-5p was the only miRNA to be significantly upregulated in the serum of both patients with UCAD and SCAD.ConclusionIn conclusion, miR-122-5p and miR-223-3p might be markers of plaque instability.
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10

Suh, Sang Hyun, Harry J. Cloft, John Huston, Kyung Hwa Han, and David F. Kallmes. "Interobserver variability of aneurysm morphology: discrimination of the daughter sac." Journal of NeuroInterventional Surgery 8, no. 1 (November 10, 2014): 38–41. http://dx.doi.org/10.1136/neurintsurg-2014-011471.

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ObjectiveSeveral definitions have been proposed to distinguish the daughter sac when treating unruptured intracranial aneurysms. The aim of this study was to evaluate interobserver variability of aneurysm morphology, including the daughter sac, using criteria from the International Study of Unruptured Intracranial Aneurysms (ISUIA) and the Unruptured Cerebral Aneurysm Study of Japan (UCAS).Materials and methodsAfter approval by the institutional review board, we analyzed three morphological features (daughter sac, lobulation, and irregular margin) from the ISUIA and UCAS using angiographic images from 102 saccular aneurysms. Four independent readers interpreted each morphological criterion using dichotomized scales (existence or not). The κ statistic was used to measure interobserver agreement, and κ>0.6 was considered substantial agreement.ResultsFor discrimination of the daughter sac, interobserver agreement among the four readers was substantial using the UCAS criteria (k=0.626 for two-dimensional (2D) and 0.659 for three-dimensional (3D) images) but not for the ISUIA criteria (k=0.487 for 2D and 0.473 for 3D images; significant difference). Irrespective of the images used, pairwise pooled κ values for the UCAS were >0.6, except for one case (score of 0.54 between readers A and B). Regarding the proportion of positive reads, there was a significant difference between reads for the daughter sac using the UCAS and ISUIA criteria.ConclusionsFor discrimination of the daughter sac, the UCAS definition showed a higher reliability than the ISUIA. However, a further prospective study is necessary to validate this definition as the treatment standard for unruptured intracranial aneurysms.
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11

Fu, Jia-Wei, Yi-Sheng Lin, Sheng-Long Gan, Yong-Rui Li, Yao Wang, Shi-Ting Feng, Hao Li, and Guo-Fu Zhou. "Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors." Contrast Media & Molecular Imaging 2019 (July 7, 2019): 1–18. http://dx.doi.org/10.1155/2019/3145647.

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In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most common UCA, microbubble, is generally close in size to a red blood cell (<∼10 μm). These microscale UCAs cannot be directly entrapped into the target cells but generate several orders of magnitude stronger echo signals than the nanoscale ones. And their large containment and high ultrasound responsiveness also greatly facilitate to perform combined treatments, e.g., drug delivery and other imaging techniques. So multifunctionalized microscale UCAs appear on this scene and keep growing toward a promising direction for precise theranostics. In this review, we systematically summarize the new advances in the principles and preparations of multifunctionalized microscale UCAs and their medical applications for malignant tumors.
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12

Appis, Andrew W., Melissa J. Tracy, and Steven B. Feinstein. "Update on the safety and efficacy of commercial ultrasound contrast agents in cardiac applications." Echo Research and Practice 2, no. 2 (May 2015): R55—R62. http://dx.doi.org/10.1530/erp-15-0018.

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Ultrasound contrast agents (UCAs) are currently used throughout the world in both clinical and research settings. The concept of contrast-enhanced ultrasound imaging originated in the late 1960s, and the first commercially available agents were initially developed in the 1980s. Today's microbubbles are designed for greater utility and are used for both approved and off-label indications. In October 2007, the US Food and Drug Administration (FDA) imposed additional product label warnings that included serious cardiopulmonary reactions, several new disease-state contraindications, and a mandated 30 min post-procedure monitoring period for the agents Optison and Definity. These additional warnings were prompted by reports of cardiopulmonary reactions that were temporally related but were not clearly attributable to these UCAs. Subsequent published reports over the following months established not only the safety but also the improved efficacy of clinical ultrasound applications with UCAs. The FDA consequently updated the product labeling in June 2008 and reduced contraindications, although it continued to monitor select patients. In addition, a post-marketing program was proposed to the sponsors for a series of safety studies to further assess the risk of UCAs. Then in October 2011, the FDA leadership further downgraded the warnings after hearing the results of the post-marketing data, which revealed continued safety and improved efficacy. The present review focuses on the use of UCAs in today's clinical practice, including the approved indications, a variety of off-label uses, and the most recent data, which affirms the safety and efficacy of UCAs.
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13

Carson, Dennis A. "NCI NanoTumor Center at UCSD." Nanomedicine: Nanotechnology, Biology and Medicine 3, no. 4 (December 2007): 332–36. http://dx.doi.org/10.1016/j.nano.2007.10.002.

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14

Tiznado, Denisse, Brent T. Mausbach, Veronica Cardenas, Dilip V. Jeste, and Thomas L. Patterson. "UCSD SORT Test (U-SORT)." Journal of Nervous and Mental Disease 198, no. 12 (December 2010): 916–19. http://dx.doi.org/10.1097/nmd.0b013e3181fe75b6.

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15

Renault, Beatrice. "A new Salk–UCSD institute?" Nature Medicine 6, no. 5 (May 2000): 489. http://dx.doi.org/10.1038/74941.

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16

Laursen, Lucas. "UCSD researcher shot by cofounder." Nature Biotechnology 31, no. 11 (November 2013): 952. http://dx.doi.org/10.1038/nbt1113-952a.

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17

Hughes, J. J. "Dual Track Applicants and UCAS." Higher Education Quarterly 47, no. 4 (October 1993): 373–77. http://dx.doi.org/10.1111/j.1468-2273.1993.tb01635.x.

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18

Battaglia, Nicolas, Neil Carlos, Roxana Martinez, and Marcelo De Vincenzi. "UAI case: An uCASE-CL model implementation." Journal of Technology and Science Education 9, no. 1 (February 1, 2019): 96. http://dx.doi.org/10.3926/jotse.543.

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The new models of teaching and learning have their focus on technology, especially on issues related to ubiquity. The impact of ICT in education generates new learning opportunities: the mobile or ubiquitous, which open new doors to technological environments that allow students to learn at any time and place, providing, in addition, tools that give the possibility to perform collaborative work and learning. The integration of a ubiquitous virtual teaching and learning environment with collaborative work forms the Ubiquitous Computer Supported Collaborative Learning model. What has been mentioned before allowed us to understand the importance of making a specification of this model that provides the possibility of using a tool for professional use in the Software Engineering during the teaching and learning processes, including the specific activities of evaluation and monitoring of works. These tools, called Computer-Aided Software Engineering, must be an active part of the uCSCL model. This integration, forms the model proposed in our work, called uCASE-CL. A prototype of the implementation of the model was developed, which we have called UAI Case. This solution is a proposal to cover the need to have tools that can be used in the teaching of the SE, and which allow the student to acquire and strengthen the academic learning.
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19

Schroeder, Courtney, Felix Kallenbach, Lena Volland, Richard FW Barnes, Colleen M. Moran, Christine Geyer, Regina von Velsen, Annette von Drygalski, and Michaela Andrea Stemberger. ""Hemophilia Vertical": Effects of Therapeutic Rock Climbing on Joint Health in Hemophilia Patients with Severe Arthropathies." Blood 128, no. 22 (December 2, 2016): 4754. http://dx.doi.org/10.1182/blood.v128.22.4754.4754.

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Abstract Background: Hemophilia is a bleeding disorder associated with frequent hemarthroses and ensuing debilitating arthropathies. Patients with hemophilia (PWH) are encouraged to participate in low impact physical activities to improve joint health, mobility, and quality of life (QoL). However, activities such as walking, swimming or physical therapy are often perceived as "boring", which results in participation in high risk activities that may cause injury or bleeding. Indoor therapeutic rock climbing is practiced successfully to improve physical and psychological well-being in patients with neuromuscular disorders, and may be a "fun" alternative for PWH. The aim of this study was to investigate the safety of therapeutic rock climbing and its effects on joint health for PWH with arthropathies. Methods: Twelve adult male patients (median age 31 years, IQR=24,41) with moderate to severe hemophilia A and arthropathies (defined by decreased normative range of motion (ROM)) were recruited from the Hemophilia Treatment Centers at University of California, San Diego, USA (UCSD) and Ludwig Maximilians University, Munich, Germany (LMU)). All participants completed 12 sessions of individually tailored indoor top rope rock climbing, instructed by a climbing coach and physical therapist. Functional and clinical joint status including ROM, Hemophilia Joint Health Score (HJHS) for elbows, knees, and ankles (n=12), climbing skills (UCSD: Yosemite Decimal Scale; LMU: Union Internationale des Associations d'Alpinisme scale), QoL measures (UCSD: Haem-A-Qol, Hep-Test-Q; LMU: Hemo-Qol-A), annual bleed rate (ABR), and clotting factor consumption were assessed in both cohorts (UCSD n=6; LMU n=6) pre and post climbing. Additionally, effects on cartilage health, joint inflammation and soft tissue hypertrophy were assessed by musculoskeletal ultrasound and power doppler (MSKUS/PD) in the UCSD cohort. Descriptive statistics and Wilcoxon matched-pairs signed-rank tests were used for data analysis. Data are expressed as median and inter-quartile range; p-values ≤ 0.05 were considered significant. Results: Compared to baseline, HJHS improved significantly after completion of the program (16.5 [IQR=6.0, 28.5] post vs 17.5 [6.0, 35.0] pre; n=12; p = 0.03). A significant increase in dorsiflexion was evident in arthropathic ankles (0 degrees [IQR= -4, 4] post vs -4 [IQR-10, -3] pre; n = 9; p<0.01), with trends towards increased ROM in arthropathic elbows and knees. All subjects advanced their climbing skills significantly (UCSD: 4 levels; LMU: 3 levels; both p-values =0.03). ABRs and clotting factor consumption were comparable before and during the climbing program for the UCSD cohort, whereas ABRs improved slightly in the LMU cohort in conjunction with pharmacokinetic tailored clotting factor therapy. Pre and post ABRs were 1 [IQR=0,4] and 0 [IQR=0,4] for the UCSD cohort (p = 1.00), and 5.5[IQR=1,8] and 1.7[IQR=0,2.3] for the LMU cohort (p=0.09), respectively. Clotting factor usage during climbing was similar between the 2 cohorts (UCSD 499 [IQR=298,593] U/kg/month; LMU 355 [IQR=250,490] U/kg/month, p = 0.39). Climbing resulted in significantly improved QoL in the LMU cohort (25.9 [IQR=21.4,30.0] points post vs 25.2 [IQR=21.0, 28.6] pre; n=6; p=0.05), but remained unchanged for the UCSD participants (p=0.31), possibly because of high QoL at outset. However, all UCSD participants voiced a meaningful increase of well-being and new confidence to overcome challenges. MSKUS/PD examinations of arthropathic joints revealed no negative effects on cartilage or soft tissue health, and demonstrated decreased inflammation. Conclusions:Therapeutic rock climbing is not only safe but improves joint health and well-being in PWH with advanced arthropathies without triggering excessive clotting factor consumption. "Hemophilia Vertical" is an innovative athletic concept without the "boring" stigma of other low impact sports, and should be promoted to advance athletic hemophilia care concepts. Disclosures von Drygalski: Pfizer: Consultancy, Honoraria, Speakers Bureau; Biogen: Consultancy, Honoraria, Speakers Bureau; CSL-Behring: Consultancy, Honoraria, Speakers Bureau; Novo Nordisk: Consultancy, Honoraria, Speakers Bureau; Bayer: Consultancy, Honoraria, Speakers Bureau; Baxalta/Shire: Consultancy, Honoraria, Speakers Bureau; Hematherix LLC: Membership on an entity's Board of Directors or advisory committees.
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Morita, Akio, Satoru Fujiwara, Kazuo Hashi, Hiroshi Ohtsu, and Takaaki Kirino. "Risk of rupture associated with intact cerebral aneurysms in the Japanese population: a systematic review of the literature from Japan." Journal of Neurosurgery 102, no. 4 (April 2005): 601–6. http://dx.doi.org/10.3171/jns.2005.102.4.0601.

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Object. Knowing the rate of rupture associated with unruptured cerebral aneurysms (UCAs) can help surgeons determine a case management strategy in patients harboring these lesions. According to large-scale cohort studies involving populations in North America and Europe, small unruptured aneurysms carry a very low risk of rupture. In Japan, however, there have been sporadic reports of higher rates of rupture. To identify the rupture risk associated with UCAs in the Japanese population, the authors systematically reviewed retrospective studies of the natural course of these lesions. Methods. The authors searched Medline and the Japan Medical Abstract Society Index for reports of UCAs in Japan. Two of the authors verified the eligibility of the reports and extracted data independently. Additional information was directly obtained from the authors of the original reports. Thirteen reports covering a total of 3801 patient-years fulfilled the criteria for our study. Subsequent rupture was documented in 104 patients and the annual rupture rate was 2.7% (95% confidence interval 2.2–3.3%). Large, posterior-circulation, and symptomatic aneurysms were associated with significantly higher rates of rupture (relative risks 6.4, 2.3, and 2.1, respectively). The risk of rupture determined by the authors' review was significantly higher than that reported by investigators from international cohort studies. Conclusions. Although a selection bias of patients may be the cause of the higher rupture risk, untreated UCAs that have been followed in Japanese institutions have a considerably high rate of rupture. The natural course of UCAs should be carefully estimated in countries not included in the international studies.
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Zeng, Shuxiong, Dongxing Nai, Yingdie Ye, Jiatao Ji, Zunlin Zhou, Baiyun Wang, Qian Ziliang, and Changliang Xu. "Non-invasive detection of urothelial carcinoma (UC) by cost-effective low-coverage whole genome sequencing from urine exfoliated cells DNA." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 1552. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.1552.

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1552 Background: Urothelial carcinoma (UC) is a malignancy with frequent chromosomal aberrations. The FISH assays were more sensitive as compared to cytology tests. Here we investigated cost-effective whole genome sequencing technology, which is able to detect all chromosomal aberrations for UC diagnoses. Methods: UC patients and control group are prospectively recruited in trial NCT03998371. First-morning-voided urine were freshly collected before TURBT or cystectomy. Urine Exfoliated Cells DNA was analyzed by illumina HiSeq X10, followed by genotyping by bioinformatics workflow UCAD. Results: 195 individuals were prospectively recruited. 121 UC patients and 67 non-tumor diseases were included in this study. 7 other malignancies as confirmed by pathological testing were excluded. Frequent chromosome copy number changes were found in cancer patients as compared non-tumor controls, including chromosome 3 gain, 17 gain, 7 gain and 9p loss used in FISH assays were found. In addition to that, chr9q loss, 8q gain, 5q loss, 17p loss, 11p loss, 1q gain, 8p loss, 10q loss, 6q loss, 4q loss and 11q loss were also frequent in cancer patients (AUC > 0.65). Metacentric chromosomes showed better AUC compared to acrocentric and telocentric chromosomes (P = 1.7e-03). A novel diagnosis model UCAD was built by incorporating all the chromosomal changes. The model reached performance of AUC = 0.933. At the optimal cutoff |Z| > = 3.16, the sensitivity, specificity and accuracy were 84.7%, 97.9% and 89.0% respectively. The prediction positivity was found correlated with urine microscopy visible epithelial cells (P = 0.00069), tumor invasiveness (Ta/Tis vs the other, P = 0.0048) and tumor grade (P = 0.0030), but not microscopy RBC/WBC findings, urine culture findings, smoke and drinking history. The UCAD model outperformed cytology tests by predicting all 16-cytology positive and 12 cytology negative tumors with comparable specificity. The model found 75.0% more tumors. And UCAD identified more upper urinary tract cancer (P = 0.012) and smaller tumors ( < 3cm, P = 5.9e-04). The adding of cytology to UCAD did not improve diagnosing sensitivity and specificity. UCAD reproduce the diagnoses among morning - void urine, morning, afternoon urine samples with correlation coefficient R2> 0.98. All the urine samples showed high concordances with matched tumor samples (R2> 0.85). Conclusions: UCAD could be a high specific, robust UC diagnoses method with improved sensitivity as compared to cytology tests. Clinical trial information: NCT03998371.
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Ullucci, Paul A., Andrew Kalach, Brian Reis, Soleil Avena, Rebecca Hinckley, Karlee Picard, and Sandra Gibson. "Seated cervical flexion-rotation test equivalent to supine for identifying cervical dysfunction in patients with dizziness/vertigo." Physiotherapy Practice and Research 41, no. 2 (January 11, 2021): 171–76. http://dx.doi.org/10.3233/ppr-200398.

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BACKGROUND: The upper cervical spine should be assessed in patients with complaints of dizziness or vertigo [1–3]. The supine cervical flexion-rotation test (SupCFRT) reliably assesses for the presence of upper cervical spine dysfunction (UCSD) [4]. UCSD has been linked to symptoms often seen in those diagnosed with dizziness or vertigo. Patients diagnosed with dizziness/vertigo often do not tolerate the supine testing position necessary to perform the SupCFRT, but often tolerate sitting well. PURPOSE: To determine if UCSD can be assessed in sitting as reliably as in supine. METHODS: Forty-five college age students (23.7±3.3 years old) acted as controls while forty-six subjects (56.71±14.6 years old) who were referred for physical therapy services by their medical provider acted as the patient group. The SupCFRT was performed first, [4] the Seated Cervical Flexion-Rotation Test (SeatCFRT) was performed next by positioning the subjects seated with their back against a high-backed chair, the head was flexed maximally, then rotated maximally left and right. The SupCFRT [4] and SeatCFRT were considered positive if range of motion limitations were found. Results for each test was compared using McNamar X2. RESULTS: There was no difference, p > 0.05, between SupCFRT and SeatCFRT for all conditions; all subjects (n = 91), control subjects n = 45, subjects referred to physical therapy for treatment of dizziness or vertigo, n = 46. DISCUSSION: The SeatCFRT reliably identifies the presence of UCSD, in controls and patients diagnosed by a referring medical provider for dizziness or vertigo. Patients, who do not tolerate the supine position, can be evaluated for UCSD in the seated position.
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Dalton, Rex. "Heat rises over UCSD 'misconduct' charge." Nature 385, no. 6617 (February 1997): 566. http://dx.doi.org/10.1038/385566a0.

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Moffat, David V. "Generic data structures in UCSD pascal." ACM SIGPLAN Notices 21, no. 8 (August 1986): 53–61. http://dx.doi.org/10.1145/382278.382394.

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25

Peterson, L. E., J. L. Matteson, and M. R. Pelling. "High energy astronomy program at UCSD." Advances in Space Research 14, no. 2 (February 1994): 151–55. http://dx.doi.org/10.1016/0273-1177(94)90082-5.

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Ikawa, Fusao, Akio Morita, Shinjiro Tominari, Takeo Nakayama, Yoshiaki Shiokawa, Isao Date, Kazuhiko Nozaki, et al. "Rupture risk of small unruptured cerebral aneurysms." Journal of Neurosurgery 132, no. 1 (January 2020): 69–78. http://dx.doi.org/10.3171/2018.9.jns181736.

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OBJECTIVEThe annual rupture rate of small (3–4 mm) unruptured cerebral aneurysms (UCAs) is 0.36% per year, however, the proportion of small ruptured aneurysms < 5 mm is 35%. This discrepancy is explained by the hypothesis that most acute subarachnoid hemorrhage (SAH) is from recently formed, unscreened aneurysms, but this hypothesis is without definitive proof. The authors aimed to clarify the actual number of screened, ruptured small aneurysms and risk factors for rupture.METHODSThe Unruptured Cerebral Aneurysm Study Japan, a project of the Japan Neurosurgical Society, was designed to clarify the natural course of UCAs. From January 2001 through March 2004, 6697 UCAs among 5720 patients were prospectively registered. At registration, 2839 patients (49.6%) had 3132 (46.8%) small UCAs of 3–4 mm. The registered, treated, and rupture numbers of these small aneurysms and the annual rupture rate were investigated. The rate was assessed per aneurysm. The characteristics of patients and aneurysms were compared to those of larger unruptured aneurysms (≥ 5 mm). Cumulative rates of SAH were estimated per aneurysm. Risk factors underwent univariate and multivariate analysis.RESULTSTreatment and rupture numbers of small UCAs were 1132 (37.1% of all treated aneurysms) and 23 (20.7% of all ruptured aneurysms), respectively. The registered, treated, rupture number, and annual rupture rates were 1658 (24.8%), 495 (16.2%), 11 (9.9%), and 0.30%, respectively, among 3-mm aneurysms, and 1474 (22.0%), 637 (20.9%), 12 (10.8%), and 0.45%, respectively, among 4-mm aneurysms. Multivariate risk-factor analysis revealed that a screening brain checkup (hazard ratio [HR] 4.1, 95% confidence interval [CI] 1.2–14.4), history of SAH (HR 10.8, 95% CI 2.3–51.1), uncontrolled hypertension (HR 5.2, 95% CI 1.8–15.3), and location on the anterior communicating artery (ACoA; HR 5.0, 95% CI 1.6–15.5) were independent predictors of rupture.CONCLUSIONSAlthough the annual rupture rate of small aneurysms was low, the actual number of ruptures was not low. Small aneurysms that ruptured during follow-up could be detected, screened, and managed based on each risk factor. Possible selection criteria for treating small UCAs include a history of SAH, uncontrolled hypertension, location on the ACoA, and young patients. Further large prospective and longitudinal trials are needed.Clinical trial registration no.: C000000418 (https://www.umin.ac.jp/ctr)
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27

Taylor, Palmer. "Cholinergic Capsules and Academic Admonitions." Annual Review of Pharmacology and Toxicology 61, no. 1 (January 6, 2021): 25–46. http://dx.doi.org/10.1146/annurev-pharmtox-061020-050936.

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Herein, I intend to capture highlights shared with my academic and research colleagues over the 60 years I devoted initially to my graduate and postdoctoral training and then to academic endeavors starting as an assistant professor in a new medical school at the University of California, San Diego (UCSD). During this period, the Department of Pharmacology emerged from a division within the Department of Medicine to become the first basic science department, solely within the School of Medicine at UCSD in 1979. As part of the school's plans to reorganize and to retain me at UCSD, I was appointed as founding chair. Some years later in 2002, faculty, led largely within the Department of Pharmacology and by practicing pharmacists within UCSD Healthcare, started the independent Skaggs School of Pharmacy and Pharmaceutical Sciences with a doctor of pharmacy (PharmD) program, where I served as the founding dean. My career pathway, from working at my family-owned pharmacy to chairing a department in a school of medicine and then becoming the dean of a school of pharmacy at a research-intensive, student-centered institution, involved some risky decisions. But the academic, curricular, and accreditation challenges posed were met by a cadre of creative faculty colleagues. I offer my experiences to individuals confronted with a multiplicity of real or imagined opportunities in academic health sciences, the related pharmaceutical industry, and government oversight agencies.
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28

Grimsley, Harper R., Daniel Claudino, Sophia E. Economou, Edwin Barnes, and Nicholas J. Mayhall. "Is the Trotterized UCCSD Ansatz Chemically Well-Defined?" Journal of Chemical Theory and Computation 16, no. 1 (December 16, 2019): 1–6. http://dx.doi.org/10.1021/acs.jctc.9b01083.

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29

Dietrich, Christoph, Michalakis Averkiou, Michael Nielsen, Richard Barr, Peter Burns, Fabrizio Calliada, Vito Cantisani, et al. "How to perform Contrast-Enhanced Ultrasound (CEUS)." Ultrasound International Open 04, no. 01 (January 2018): E2—E15. http://dx.doi.org/10.1055/s-0043-123931.

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Abstract“How to perform contrast-enhanced ultrasound (CEUS)” provides general advice on the use of ultrasound contrast agents (UCAs) for clinical decision-making and reviews technical parameters for optimal CEUS performance. CEUS techniques vary between centers, therefore, experts from EFSUMB, WFUMB and from the CEUS LI-RADS working group created a discussion forum to standardize the CEUS examination technique according to published evidence and best personal experience. The goal is to standardise the use and administration of UCAs to facilitate correct diagnoses and ultimately to improve the management and outcomes of patients.
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30

Kezoudi, Maria, Matthias Tesche, Helen Smith, Alexandra Tsekeri, Holger Baars, Maximilian Dollner, Víctor Estellés, et al. "Measurement report: Balloon-borne in situ profiling of Saharan dust over Cyprus with the UCASS optical particle counter." Atmospheric Chemistry and Physics 21, no. 9 (May 5, 2021): 6781–97. http://dx.doi.org/10.5194/acp-21-6781-2021.

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Abstract. This paper presents measurements of mineral dust concentration in the diameter range from 0.4 to 14.0 µm with a novel balloon-borne optical particle counter, the Universal Cloud and Aerosol Sounding System (UCASS). The balloon launches were coordinated with ground-based active and passive remote-sensing observations and airborne in situ measurements with a research aircraft during a Saharan dust outbreak over Cyprus from 20 to 23 April 2017. The aerosol optical depth at 500 nm reached values up to 0.5 during that event over Cyprus, and particle number concentrations were as high as 50 cm−3 for the diameter range between 0.8 and 13.9 µm. Comparisons of the total particle number concentration and the particle size distribution from two cases of balloon-borne measurements with aircraft observations show reasonable agreement in magnitude and shape despite slight mismatches in time and space. While column-integrated size distributions from balloon-borne measurements and ground-based remote sensing show similar coarse-mode peak concentrations and diameters, they illustrate the ambiguity related to the missing vertical information in passive sun photometer observations. Extinction coefficient inferred from the balloon-borne measurements agrees with those derived from coinciding Raman lidar observations at height levels with particle number concentrations smaller than 10 cm−3 for the diameter range from 0.8 to 13.9 µm. An overestimation of the UCASS-derived extinction coefficient of a factor of 2 compared to the lidar measurement was found for layers with particle number concentrations that exceed 25 cm−3, i.e. in the centre of the dust plume where particle concentrations were highest. This is likely the result of a variation in the refractive index and the shape and size dependency of the extinction efficiency of dust particles along the UCASS measurements. In the future, profile measurements of the particle number concentration and particle size distribution with the UCASS could provide a valuable addition to the measurement capabilities generally used in field experiments that are focussed on the observation of coarse aerosols and clouds.
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31

Gordetsky, Jennifer B., Kathleen W. Montgomery, Giovanna A. Giannico, Soroush Rais-Bahrami, Prabin Thapa, Stephen Boorjian, Igor Frank, and John Cheville. "The Significance of Squamous Histology on Clinical Outcomes and PD-L1 Expression in Bladder Cancer." International Journal of Surgical Pathology, June 28, 2021, 106689692110272. http://dx.doi.org/10.1177/10668969211027264.

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Objectives. To compare the clinicopathologic characteristics of urothelial carcinoma (UC), urothelial carcinoma with squamous differentiation (UCSD), and squamous cell carcinoma (SCC) of the bladder, which have been suggested to differ in terms of risk factors, immunophenotype, and prognosis. Methods. We evaluated the clinicopathologic features of radical cystectomy specimens between 1980 and 2015 with a diagnosis of SCC, UCSD, and UC. PD-L1 immunohistochemistry (clinically available clones 22C3, SP142, and SP263) was performed on SCC and UCSD. Multivariate Cox regression was used to identify prognostic factors. Kaplan–Meier curves were plotted to assess cancer-specific survival (CSS). Results. Of the 1478 cases, there were 1126 UC (76%), 217 UCSD (15%), and 135 SCC (9%). Bladder cancer was more common in men than women (80% vs 20%, P < .0001). However, a higher proportion of SCC and UCSD occurred in women (SCC-36%, UCSD-22%, UC-18%). Women were significantly more likely to be never smokers in all 3 cohorts (UC: 45% vs 16%, UCSD: 44% vs 12%, SCC: 40% vs 18%, P < .0001). Patients with SCC and UCSD were at a higher pathologic stage (>pT2) at the time of cystectomy (UCSD-74%, SCC 71%, UC-44%, P < .0001) and had worse CSS compared to patients with UC ( P = 0.006). SCC had higher PD-L1 scores (all clones) than UCSD ( P < .0001). PD-L1 22C3 ( P = .02, HR: 0.36) and SP142 scores ( P = .046, HR: 0.27) predicted CSS on Kaplan–Meier analysis for SCC cases. Conclusions. UC, UCSD, and SCC are associated with different risk factors, gender distributions, and clinical outcomes. PD-L1 is expressed in SCC and UCSD, suggesting some patients may benefit from targeted therapy.
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32

Zheng, Jianfeng, Ru Xu, Xiaochuan Sun, and Xiaodong Zhang. "Small vs. Large Unruptured Cerebral Aneurysm: Concerns With the Age of Patient." Frontiers in Neurology 12 (September 21, 2021). http://dx.doi.org/10.3389/fneur.2021.735456.

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Objective: The coiling and clipping of unruptured cerebral aneurysms (UCAs) in older patients has increased rapidly, and aneurysm size was a significant factor for decision-making in the treatment of UCAs. The purpose of the study was to investigate the impact of age on the functional outcomes of patients between the small versus large UCAs.Methods: We conducted a retrospective study for consecutive cases of UCAs admitted from May 2011 to December 2020. According to the maximum diameter of UCA, patients were divided into small UCAs (≤ 5 mm) group and large UCAs (&gt;5 mm) group. Baseline characteristics, clinical complications, and outcomes of patients between the two groups were analyzed.Results: A total of 564 UCA patients received preventive treatment, including 165 small UCAs and 399 large UCAs. Compared with the small UCA group, the incidence of ischemia event in the large UCA group was significantly higher (7.3 vs. 2.4%; p = 0.029). Multivariable analysis demonstrating age (p = 0.006) and treatment modality (p &lt; 0.001) were independent risk factors associated with poor outcome for patients with large UCAs.Conclusions: Preventive treatment of small UCAs is safe and effective, but older patients with large UCAs are at high risk of poor outcome, and the operations should be more cautious.
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33

Brain & Neural Networks 4, no. 2 (1997): 97–100. http://dx.doi.org/10.3902/jnns.4.97.

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34

"UCSD Mitochondrial Medicine Conference." Molecular Genetics and Metabolism 63, no. 1 (January 1998): 37–73. http://dx.doi.org/10.1016/s1096-7192(97)92663-9.

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35

"Gabriel Rebeiz joins UCSD." IEEE Antennas and Propagation Magazine 46, no. 6 (December 2004): 90. http://dx.doi.org/10.1109/map.2004.1396738.

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36

"UCSD Mitochondrial Medicine Conference." Molecular Genetics and Metabolism 63, no. 1 (January 1998): 37–73. http://dx.doi.org/10.1006/mgme.1997.2663.

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37

Wang, Yu, Hailin Cong, Song Wang, Bing Yu, and Youqing Shen. "Development and application of ultrasound contrast agents in biomedicine." Journal of Materials Chemistry B, 2021. http://dx.doi.org/10.1039/d1tb00850a.

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Ultrasound contrast agents (UCAs) play a crucial role in the integration of US diagnosis and treatment. UCAs have also been studied in the fields of US thrombolysis, mediated gene transfer, drug delivery, and high intensity focused US.
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38

"UCSD gets a tacky present." Materials Today 5, no. 1 (January 2002): 20. http://dx.doi.org/10.1016/s1369-7021(02)05135-0.

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39

"The German page at UCSD: literature." Choice Reviews Online 35, no. 12 (August 1, 1998): 35SUP—114–35SUP—114. http://dx.doi.org/10.5860/choice.35sup-114.

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40

"Scripps Institution of Oceanography Library, UCSD." Choice Reviews Online 37, no. 12 (August 1, 2000): 37Sup—310–37Sup—310. http://dx.doi.org/10.5860/choice.37sup-310.

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41

Jones, Steven. "The problem with UCAS personal statements." SecEd 2012, no. 6 (June 2012). http://dx.doi.org/10.12968/sece.2012.6.20.

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42

"UCSD BACKS OFF ON BONE BID." Science 324, no. 5925 (April 17, 2009): 317b. http://dx.doi.org/10.1126/science.324.5925.317b.

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43

"NSF Grant to Bolster UCSD Bioinformatics." Clinical OMICs 4, no. 3 (May 2017): 33. http://dx.doi.org/10.1089/clinomi.04.03.31.

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44

"A UCSD Pascal/Modula-2 translator." Microprocessors and Microsystems 12, no. 2 (March 1988): 114. http://dx.doi.org/10.1016/0141-9331(88)90061-0.

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45

Nalbantgil, Sanem. "İleri evre kalp yetersizliği rehberi." Updates in Cardiology 1, no. 1 (2018). http://dx.doi.org/10.5543/ucard.2018.43153.

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46

ilerigelen, Barış. "Beta-blockers in cardiovascular prevention." Updates in Cardiology, 2019. http://dx.doi.org/10.5543/ucard.2019.00719.

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47

Sinan, Ümit Yaşar. "Diet and lifestyle modifications." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.02996.

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48

Başaran, Özcan. "Statin Intolerance." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.09719.

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Güngör, Barış. "Lipid lowering therapy in particular patient populations." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.09797.

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50

Komşuoğlu Çelikyurt, İpek. "Pharmacological properties of nebivolol." Updates in Cardiology, 2019. http://dx.doi.org/10.5543/ucard.2019.21931.

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