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Huamán Mendoza, Aldrin André, Freddy Ronald Valdez Jurado, Hugo André Sánchez Pachas Aranda, and Florencio De la Torre Moreno. "Factores asociados a la recesión de la papila interdental de incisivos centrales superiores en adultos del Hospital Central de la Fuerza Aérea del Perú." Revista Estomatológica Herediana 28, no. 2 (July 4, 2018): 78. http://dx.doi.org/10.20453/reh.v28i2.3323.
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Objetivo: Identificar los principales factores asociados a la recesión de la papila interdental de incisivos centrales superiores. Material y métodos: Se analizó una muestra no probabilística de 86 pacientes de la sección de Periodoncia e Implantes del Departamento de Estomatología del Hospital Central de la Fuerza Aérea del Perú. El tipo de estudio fue observacional, correlacional simple, transversal y prospectivo. Se evaluaron clínicamente factores como forma coronal dentaria y biotipo gingival; y radiográficamente distancias de la unión cemento esmalte proximal al punto de contacto interdentario (UCEp-PC), punta de la papila al punto de contacto interdentario (PP-PC), cresta ósea al punto de contacto interdentario (CO-PC), cresta ósea a la unión cemento esmalte proximal (CO-UCEp), ancho interdental (AI), ancho de la cresta ósea (AC) y ancho de la punta de la papila (APP). Resultados: En todos los pacientes de estudio, el nivel de recesión, CO-PC y APP fueron predictores individuales significativos (p
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Meijer, Paul H. E. "Metamorphosis from LCEP to UCEP in the Metastable Three-Phase Region." Journal of Physical Chemistry B 103, no. 24 (June 1999): 5084–91. http://dx.doi.org/10.1021/jp990246u.
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Zhang, D., L. Wang, W. Sheng, and B. C. Y. Lu. "Experimental determination ofP-X, L=Gcritical locus and UCEP for Biphenyl-Co2mixtures." Canadian Journal of Chemical Engineering 69, no. 6 (December 1991): 1352–56. http://dx.doi.org/10.1002/cjce.5450690617.
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Okuno, R., and Z. Xu. "Mass Transfer on Multiphase Transitions in Low-Temperature Carbon-Dioxide Floods." SPE Journal 19, no. 06 (April 10, 2014): 1005–23. http://dx.doi.org/10.2118/166345-pa.
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Summary Mixtures of reservoir oil and carbon dioxide (CO2) can exhibit complex multiphase behavior at temperatures typically less than 120°F, in which a third CO2-rich liquid (L2) phase can coexist with the oleic (L1) and gaseous (V) phases. The three-phase behavior is bounded by two types of critical endpoints (CEPs) in composition space. The lower CEP (LCEP) is a tie line in which the two liquid phases merge in the presence of the V phase, and the upper CEP (UCEP) is a tie line in which the L2 and V phases merge in the presence of the L1 phase. Slimtube tests reported in the literature show that low-temperature oil displacement by CO2 can result in the high displacement efficiency of more than 90% when three phases are present during the displacement. The nearly piston-like displacements can be quantitatively reproduced in numerical simulations when the CEP behavior is properly considered. However, it is uncertain how multicontact miscibility (MCM) is developed through the interaction of flow and three-hydrocarbon-phase behavior. This research presents a detailed analysis of mass conservation on multiphase transitions between two and three phases for the limiting three-phase flow, where the L1 phase is completely displaced by the L2 phase on the LCEP. The analysis indicates that interphase mass transfer on multiphase transitions occurs in the most-efficient way for MCM development. Simple analytical conditions derived for MCM through three phases are applied to 1D fine-scale simulations of CO2 floods by use of four and more components. Results show that the MCM conditions are nearly satisfied when the effect of numerical dispersion is small. MCM is likely developed through three hydrocarbon phases on the LCEP in the cases studied. This is consistent with analytical solutions of water and gas injection presented in the literature, in which MCM is developed on a CEP for the aqueous, V, and L1 phases. For MCM cases in this research, the L2-V two phases are present upstream of the miscible front if the composition path does not go through the UCEP tie line. However, they also can be miscible on the non-L1 edge of the UCEP tie line if the MCM composition path goes through it. Three-phase flow gradually changes to two-phase flow with varying pressure in the presence of numerical dispersion. It is shown that interphase mass transfer on multiphase transitions becomes less efficient during the change until the three-phase region completely disappears.
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Novák, Josef P., Vlastimil Růžička, Jaroslav Matouš, and Jiří Pick. "Liquid-liquid equilibrium. Computation of liquid-liquid equilibrium in terms of an equation of state." Collection of Czechoslovak Chemical Communications 51, no. 7 (1986): 1382–92. http://dx.doi.org/10.1135/cccc19861382.
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An algorithm for calculating the boiling point pressure at a chosen temperature and composition was used for computing liquid-liquid equilibrium. A lot of attention is paid to the determination of the first approximation which is specified in terms of the conditions of thermodynamic stability. The conditions of thermodynamic stability make as well possible to localize the lower and upper critical end points (LCEP and UCEP. The Redlich-Kwong-Soave equation of state was applied in calculations, and it was found out that this equation with zero interaction parameters predicts well the lower and upper critical end temperatures in the systems methane-n-hexane, ethane-n-eicosane and ethane-n-docosane.
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Meijer, Paul H. E. "The metamorphosis from LCEP to UCEP in the metastable three-phase region in type V phase-diagrams." Fluid Phase Equilibria 158-160 (June 1999): 575–82. http://dx.doi.org/10.1016/s0378-3812(99)00095-3.
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Shohel, M. Mahruf C., and Frank Banks. "Teachers’ professional development through the English in action secondary teaching and learning programme in Bangladesh: Experience from the UCEP schools." Procedia - Social and Behavioral Sciences 2, no. 2 (2010): 5483–94. http://dx.doi.org/10.1016/j.sbspro.2010.03.894.
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Houde, Peter, Edward L. Braun, Nitish Narula, Uriel Minjares, and Siavash Mirarab. "Phylogenetic Signal of Indels and the Neoavian Radiation." Diversity 11, no. 7 (July 6, 2019): 108. http://dx.doi.org/10.3390/d11070108.
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The early radiation of Neoaves has been hypothesized to be an intractable “hard polytomy”. We explore the fundamental properties of insertion/deletion alleles (indels), an under-utilized form of genomic data with the potential to help solve this. We scored >5 million indels from >7000 pan-genomic intronic and ultraconserved element (UCE) loci in 48 representatives of all neoavian orders. We found that intronic and UCE indels exhibited less homoplasy than nucleotide (nt) data. Gene trees estimated using indel data were less resolved than those estimated using nt data. Nevertheless, Accurate Species TRee Algorithm (ASTRAL) species trees estimated using indels were generally similar to nt-based ASTRAL trees, albeit with lower support. However, the power of indel gene trees became clear when we combined them with nt gene trees, including a striking result for UCEs. The individual UCE indel and nt ASTRAL trees were incongruent with each other and with the intron ASTRAL trees; however, the combined indel+nt ASTRAL tree was much more congruent with the intronic trees. Finally, combining indel and nt data for both introns and UCEs provided sufficient power to reduce the scope of the polytomy that was previously proposed for several supraordinal lineages of Neoaves.
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Okuno, R., R. T. T. Johns, and K. Sepehrnoori. "Mechanisms for High Displacement Efficiency of Low-Temperature CO2 Floods." SPE Journal 16, no. 04 (June 28, 2011): 751–67. http://dx.doi.org/10.2118/129846-pa.
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Summary CO2 floods at temperatures typically below 120°F can involve complex phase behavior, where a third CO2-rich liquid (L2) phase coexists with the oleic (L1) and gaseous (V) phases. Results of slimtube measurements in the literature show that an oil displacement by CO2 can achieve high displacement efficiency of more than 90% when three hydrocarbon phases coexist during the displacement. However, the mechanism for the high-displacement efficiency is uncertain because the complex interaction of phase behavior with flow during the displacement is not fully understood. In this paper, we present the first detailed study of three-phase behavior predictions and displacement efficiency for low-temperature CO2 floods. Four-component EOS models are initially used to investigate systematically the effects of pressure, temperature, and oil properties on development of three-phase regions and displacement efficiency. Multicomponent oil displacements by CO2 are then considered. We use a compositional reservoir simulator capable of robust three-phase equilibrium calculations. Results show that high displacement efficiency of low-temperature CO2 floods is a consequence of both condensing and vaporizing behavior. The L2 phase serves as a buffer between the immiscible V and L1 phases within the three-phase region. Components in the L1 phase first transfer efficiently to the L2 phase near a lower critical endpoint (LCEP). These oil components then transfer to the V phase near an upper critical endpoint (UCEP) at the trailing edge of the three-phase region. The CEPs are defined where two of the three coexisting phases merge in the presence of the other immiscible phase. Unlike two-phase displacements, condensation and vaporization of intermediate components occur simultaneously within the three-phase region. The simultaneous condensing/vaporizing behavior involving the CEPs is also confirmed for simulations of several west Texas oil displacements. Quaternary fluid models can predict qualitatively the complex displacements because four is the minimum number of components to develop CEP behavior in composition space at a fixed temperature and pressure.
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Karin, Benjamin R., Tony Gamble, and Todd R. Jackman. "Optimizing Phylogenomics with Rapidly Evolving Long Exons: Comparison with Anchored Hybrid Enrichment and Ultraconserved Elements." Molecular Biology and Evolution 37, no. 3 (November 9, 2019): 904–22. http://dx.doi.org/10.1093/molbev/msz263.
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Abstract Marker selection has emerged as an important component of phylogenomic study design due to rising concerns of the effects of gene tree estimation error, model misspecification, and data-type differences. Researchers must balance various trade-offs associated with locus length and evolutionary rate among other factors. The most commonly used reduced representation data sets for phylogenomics are ultraconserved elements (UCEs) and Anchored Hybrid Enrichment (AHE). Here, we introduce Rapidly Evolving Long Exon Capture (RELEC), a new set of loci that targets single exons that are both rapidly evolving (evolutionary rate faster than RAG1) and relatively long in length (>1,500 bp), while at the same time avoiding paralogy issues across amniotes. We compare the RELEC data set to UCEs and AHE in squamate reptiles by aligning and analyzing orthologous sequences from 17 squamate genomes, composed of 10 snakes and 7 lizards. The RELEC data set (179 loci) outperforms AHE and UCEs by maximizing per-locus genetic variation while maintaining presence and orthology across a range of evolutionary scales. RELEC markers show higher phylogenetic informativeness than UCE and AHE loci, and RELEC gene trees show greater similarity to the species tree than AHE or UCE gene trees. Furthermore, with fewer loci, RELEC remains computationally tractable for full Bayesian coalescent species tree analyses. We contrast RELEC to and discuss important aspects of comparable methods, and demonstrate how RELEC may be the most effective set of loci for resolving difficult nodes and rapid radiations. We provide several resources for capturing or extracting RELEC loci from other amniote groups.
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Winker, Kevin, Travis C. Glenn, and Brant C. Faircloth. "Ultraconserved elements (UCEs) illuminate the population genomics of a recent, high-latitude avian speciation event." PeerJ 6 (October 5, 2018): e5735. http://dx.doi.org/10.7717/peerj.5735.
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Using a large, consistent set of loci shared by descent (orthologous) to study relationships among taxa would revolutionize among-lineage comparisons of divergence and speciation processes. Ultraconserved elements (UCEs), highly conserved regions of the genome, offer such genomic markers. The utility of UCEs for deep phylogenetics is clearly established and there are mature analytical frameworks available, but fewer studies apply UCEs to recent evolutionary events, creating a need for additional example datasets and analytical approaches. We used UCEs to study population genomics in snow and McKay’s buntings (Plectrophenax nivalis and P. hyperboreus). Prior work suggested divergence of these sister species during the last glacial maximum (∼18–74 Kya). With a sequencing depth of ∼30× from four individuals of each species, we used a series of analysis tools to genotype both alleles, obtaining a complete dataset of 2,635 variable loci (∼3.6 single nucleotide polymorphisms/locus) and 796 invariable loci. We found no fixed allelic differences between the lineages, and few loci had large allele frequency differences. Nevertheless, individuals were 100% diagnosable to species, and the two taxa were different genetically (FST = 0.034; P = 0.03). The demographic model best fitting the data was one of divergence with gene flow. Estimates of demographic parameters differed from published mtDNA research, with UCE data suggesting lower effective population sizes (∼92,500–240,500 individuals), a deeper divergence time (∼241,000 years), and lower gene flow (2.8–5.2 individuals per generation). Our methods provide a framework for future population studies using UCEs, and our results provide additional evidence that UCEs are useful for answering questions at shallow evolutionary depths.
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Oltramari, Leandro Castro, and Brigido Vizeu Camargo. "Representações sociais de mulheres profissionais do sexo sobre a AIDS." Estudos de Psicologia (Natal) 9, no. 2 (August 2004): 317–23. http://dx.doi.org/10.1590/s1413-294x2004000200013.
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Este estudo trata do risco da AIDS para profissionais do sexo e seus parceiros. Foram entrevistadas 40 mulheres com idade entre 19 e 47 anos. Pouco menos da metade tinha parceiro fixo. Utilizaram-se entrevistas semi-estruturadas para a obtenção do material verbal, que foi analisado pelo software ALCESTE. Verificaram-se três aspectos da representação social da AIDS: o primeiro destaca-a como uma doença do "outro" (48,3% das unidades de contexto elementar, ou UCE); o segundo define-a como uma doença que ameaça todos os que não usam preservativo (26,7% das UCEs); e o terceiro estabelece ligação da AIDS com uso de drogas e pessoas "suspeitas" (25,0% das UCEs). Conclui-se que as mulheres que têm relação com parceiro fixo não-cliente e com clientes são mais vulneráveis que as outras, pois elas não transferem a experiência de proteção adotada diante dos clientes para as relações com seus parceiros fixos.
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Willson, William, Robert J. Parsons, and Chris Funk. "UCHP." Health Marketing Quarterly 13, no. 1 (February 13, 1996): 3–18. http://dx.doi.org/10.1300/j026v13n01_02.
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Mishima, Katsuaki, Yoshihide Mori, Toshio Sugahara, and Masayoshi Sakuda. "Comparison between the Palatal Configurations in Complete and Incomplete Unilateral Cleft Lip and Palate Infants under 18 Months of Age." Cleft Palate-Craniofacial Journal 38, no. 1 (January 2001): 49–54. http://dx.doi.org/10.1597/1545-1569_2001_038_0049_cbtpci_2.0.co_2.
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Objective The purpose of this study was to examine the three-dimensional characteristics of the palatal configurations in incomplete unilateral cleft lip and palate (UCLP) patients and to determine whether there are differences in the effect of early orthopedic treatment between complete and incomplete UCLP patients. Design Eight infants with incomplete UCLP and 12 infants with complete UCLP, selected at random, wore Hotz plates, and 8 other infants with complete UCLP did not. Palatal impressions were taken of these patients immediately after birth and at 1, 2, 3, 4 (just before cheiloplasty), 6, and 18 months of age (just before palatoplasty). Using our measuring system, the palatal casts were measured and compared three-dimensionally. Results and Conclusions The palate of the incomplete UCLP patients measured immediately after birth, compared with complete UCLP, showed: (1) smaller posterior arch width; (2) sagittal arch length did not differ; (3) incisal point was located more mesially; (4) the gap between the alveolar arch forms of the major and minor segments was smaller; and (5) the curvature of the palatal surface forward the nasal cavity in the minor segment was less. At 18 months of age, the following characteristics could be observed: (1) the difference observed at birth in the posterior arch width between the incomplete and complete UCLP infants vanished; (2) a significant difference in the location of the incisal point was observed only between the incomplete UCLP infants and the complete UCLP infants with a Hotz plate; and (3) the curvature was less in the incomplete UCLP infants than in the complete UCLP infants. Furthermore, the morphological change of the palatal surface was less in the incomplete UCLP infants than in the complete UCLP infants. This suggested that any influence of the Hotz appliance might be less in incomplete UCLP than in complete UCLP.
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Guryev, Evgenii L., Natalia O. Volodina, Natalia Y. Shilyagina, Sergey V. Gudkov, Irina V. Balalaeva, Arthur B. Volovetskiy, Alexander V. Lyubeshkin, et al. "Radioactive (90Y) upconversion nanoparticles conjugated with recombinant targeted toxin for synergistic nanotheranostics of cancer." Proceedings of the National Academy of Sciences 115, no. 39 (September 7, 2018): 9690–95. http://dx.doi.org/10.1073/pnas.1809258115.
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We report combined therapy using upconversion nanoparticles (UCNP) coupled to two therapeutic agents: beta-emitting radionuclide yttrium-90 (90Y) fractionally substituting yttrium in UCNP, and a fragment of the exotoxin A derived fromPseudomonas aeruginosagenetically fused with a targeting designed ankyrin repeat protein (DARPin) specific to HER2 receptors. The resultant hybrid complex UCNP-R-T was tested using human breast adenocarcinoma cells SK-BR-3 overexpressing HER2 receptors and immunodeficient mice, bearing HER2-positive xenograft tumors. The photophysical properties of UCNPs enabled background-free imaging of the UCNP-R-T distribution in cells and animals. Specific binding and uptake of UCNP complexes in SK-BR-3 cells was observed, with separate90Y- and PE40-induced cytotoxic effects characterized by IC50140 μg/mL (UCNP-R) and 5.2 μg/mL (UCNP-T), respectively. When both therapeutic agents were combined into UCNP-R-T, the synergetic effect increased markedly, ∼2200-fold, resulting in IC50= 0.0024 μg/mL. The combined therapy with UCNP-R-T was demonstrated in vivo.
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Sano, Tomoyasu, Ryohei Hattori, Shin Yamada, Osamu Kamihira, Hiroaki Kobayashi, Yoshikazu Tsuji, Naoto Sassa, Momokazu Gotoh, and Toyonori Tsuzuki. "Proposal of a new subcategory of the pT3 classification: Effects of tumor location and subclassification of renal pelvic pT3 to predict the prognosis of pelvic carcinoma more accurately than the current TNM classification." Journal of Clinical Oncology 38, no. 6_suppl (February 20, 2020): 455. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.455.
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455 Background: Whether pT3 urothelial carcinoma of the renal pelvis (UCRP) and urothelial carcinoma of the ureter (UCU) show the same prognosis or not remains controversial.This study aims to reveal whether the prognosis of pT3 UCRP shows similar to those of pT3 UCU. Methods: We retrospectively evaluated 954 patients who underwent nephroureterectomy between 1983 and 2017 at our institutions.None of the patients received neoadjuvant therapy.All HE slides for each patient were reviewed by a single genitourinary pathologist (TT).pT3 UCRP was subdivided pT3a (urothelial carcinomas that extend only to the renal medulla) and pT3b (urothelial carcinomas that extend to the renal cortex and/or peripelvic adipose tissue) according to the criteria previously we proposed.Fine and Gray model was developed to predict the reccurence-free survival (RFS) and cancer-specific survival (CSS). Results: Overall, 954 patients were eligible for this study, 493 of whom were pT3 with only renal pelvis and 461 of whom were pT3 with only ureter. A total of 202 cases were pT3 UCRP and 146 were pT3 UCU. The pT3 subclassification of UCRP resulted in 79 pT3a and 120 pT3b cases.No significant difference was found in the 5-yr RFS and 5-yr CSS between pT3a UCRP and pT2 UCRP and pT2 UCU. (RFS; pT3a UCRP vs pT2 UCRP: HR = 1.19 p = 0.74; pT3a UCRP vs pT2 UCU HR = 0.88, p = 0.72, CSS;pT3a UCRP vs. pT2 UCRP: HR = 0.69; p = 0.56; pT3a UCRP vs. pT2 UCU: HR = 0.66, p = 0.31) The RFS rate was significantly higher in the pT3a UCRP than that of pT3b, (pT3a vs pT3b: HR = 2.59, p = 0.0038) and so was the CSS rate. (pT3a vs. pT3b: HR = 3.1 p = 0.001) In fine and gray model analysis for RFS, pT stage, lymph node metastasis, WHO/ISUP grade, lymphovascular invasion were independently associated with tumor recurrence, whereas pT stage, lymph node metastasis, operation method, histologic type, lymphovascular invasion, gross type, adjuvant chemotherapy were independently associated with cancer mortality. Conclusions: Subclassifying pT3 UCRP into pT3a and pT3b was useful in determining the prognosis of different patients.The pT3b UCRP showed similar outcome compared to those of UCU.
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Yamanishi, T., C. Kobayashi, I. Tsujimoto, H. Koizumi, S. Miya, Y. Yokota, R. Okamoto, et al. "An Uncommon Cleft Subtype of Unilateral Cleft Lip and Palate." Journal of Dental Research 87, no. 2 (February 2008): 164–68. http://dx.doi.org/10.1177/154405910808700212.
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The finding that the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively influences palatal development, and this hypothesis was tested. Sixty persons with complete UCLP, including those with the vomer detached from (n = 30, b-UCLP) and attached to (n = 30, u-UCLP) the secondary hard palate, were analyzed morphologically, with the use of cast models taken at 10 days, 3 mos, and 12 mos of age. The anterio-posterior palatal length at 12 mos of age in those with b-UCLP was significantly shorter than that in those with u-UCLP, by 8.7% (p < 0.05). In addition, palatal width development in the first year in those with b-UCLP was also significantly retarded. These results suggest that the uncommon bilateral cleft subtype in UCLP should be included in the cleft classification.
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Ivy Kiemle, Trindade-Suedam, Freire Lima Thiago, Dominguez Campos Letícia, Faria Yaedú Renato Yassutaka, Filho Hugo Nary, and Kiemle Trindade Inge Elly. "Tomographic Pharyngeal Dimensions in Individuals with Unilateral Cleft Lip/Palate and Class III Malocclusion are Reduced When Compared with Controls." Cleft Palate-Craniofacial Journal 54, no. 5 (September 2017): 502–8. http://dx.doi.org/10.1597/15-124.
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Objective The objective of this study was to three-dimensionally evaluate the pharyngeal dimensions of individuals with complete nonsyndromic unilateral cleft lip and palate (UCLP) using cone beam computed tomography. Design This was a cross-sectional prospective study. Setting The study took place at the Laboratory of Physiology, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru-SP, Brazil. Patients and Participants The control group (CON) consisted of 23 noncleft adults with class III malocclusion, and the cleft group (UCLP) consisted of 22 individuals with UCLP and class III malocclusion. Two subgroups of individuals with class III malocclusion as a result of maxillary retrusion with (UCLP'; n = 19) and without (CON'; n = 8) clefts were also assessed. Interventions Pharyngeal volume, pharyngeal minimal cross-sectional area (CSA), location of CSA, pharyngeal length, sella-nasion-A point angle (SNA), sella-nasion-B point angle (SNB), and A point-nasion-B point angle (ANB), and body mass index were assessed using Dolphin software. Main Outcome Measure The pharyngeal dimensions of UCLP individuals are smaller when compared with controls. Results Mean pharyngeal volume (standard deviation) for the UCLP patients (20.8 [3.9] cm3) and the UCLP’ patients (20.3 [3.9] cm3) were significantly decreased when compared with the CON (28.2 [10.0] cm3) and CON’ patients (29.1 [10.2] cm3), respectively. No differences were found in the pharyngeal minimal CSA, ANB, or pharyngeal length values between groups (CON versus UCLP and CON’ versus UCLP'). CSAs were located mostly at the oropharynx, except in the UCLP’ patients, which were mainly at the hypopharynx. Mean SNA in the UCLP (76.4° [4.6°]) and UCLP’ groups (75.1 [3.1°]) were significantly smaller than those in the CON (82.8° [4.1°]) and CON’ groups (78.6° [1.2°]). SNB values were statistically smaller only for the comparison of CON versus UCLP patients. Conclusion The pharynx of individuals with UCLP and class III malocclusion is volumetrically smaller than that of individuals with class III malocclusion and no clefts.
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FUJINO, Masato, Kazuo SHINOZAKI, Yukikazu NATORI, and Kazuhisa OHTAGUCHI. "The concept of UCEE Researcher Database." Journal of Information Processing and Management 50, no. 5 (2007): 266–79. http://dx.doi.org/10.1241/johokanri.50.266.
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Scott, David. "Understanding the Categories and their Natural Properties." Magis, Revista Internacional de Investigación en Educación 11, no. 22 (October 16, 2018): 33–42. http://dx.doi.org/10.11144/javeriana.m11-22.ucnp.
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There are four ways of distinguishing theories or models about categories such as quantity, race and dis-ability and the relationship between mind and world. (i) Epistemic: a theory is superior to another because it has a better relationship with the world. (ii) The converse: a version of reality is superior to another because it contains fewer contradictions and disjunctions. (iii) The giving of reasons: some reasons and systems of rationality are superior to others. (iv) Pragmatic: a theory is better than another because it is more practically adequate. I suggest that a combination of all four reasons is appropriate.
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Pinzón Vargas, Sandy, and Atilio Moreno Carrillo. "Uso y capacitación en ecografía en el departamento de emergencias." Universitas Médica 54, no. 3 (September 5, 2013): 353–60. http://dx.doi.org/10.11144/javeriana.umed54-3.uced.
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La realización de ultrasonografía se ha convertido en una práctica habitual en muchos departamentos de emergencia de Estados Unidos, lo cual ha generado que la mayoría de los programas de residencia de medicina de urgencias incluyan la formación en ultrasonido dentro de su currículo. En los servicios de urgencias se ha generado la necesidad de utilizar el ecógrafo para permitir un diagnóstico rápido de patologías que requieren identificarse inmediatamente dada su alta mortalidad, como son la hemorragia intrabdominal en el contexto del paciente con traumatismos, aneurisma de aorta, taponamiento cardiaco, neumotórax, entre otros. Su aplicación genera la oportunidad de un diagnóstico oportuno y un rápido tratamiento, y con ello se logra disminuir la estancia de los pacientes en urgencias. Además, su realización evita la necesidad de traslado de pacientes potencialmente inestables fuera del área de reanimación, que puede llegar a generar complicaciones relacionadas con el desplazamiento. La ultrasonografía se ha convertido en una herramienta segura para la realización de procedimientos, como accesos vasculares, paracentesis, toracentesis, etc., pues disminuye el riesgo de posibles complicaciones que se presentan cuando estos procedimientos son realizados a ciegas.
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Zhang, Junping, Fuyao Liu, Tao Li, Xiuxia He, and Zhenxin Wang. "Surface charge effect on the cellular interaction and cytotoxicity of NaYF4:Yb3+, Er3+@SiO2 nanoparticles." RSC Advances 5, no. 10 (2015): 7773–80. http://dx.doi.org/10.1039/c4ra11374h.
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The positively charged UCNP@SiO2-PEG-NH2 exhibits higher cytotoxicity and cellular internalization efficiency than negatively charged UCNP@SiO2-COOH and UCNP@SiO2-PEG.
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Loeb, K. R., and A. L. Haas. "Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern." Molecular and Cellular Biology 14, no. 12 (December 1994): 8408–19. http://dx.doi.org/10.1128/mcb.14.12.8408.
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Ubiquitin cross-reactive protein (UCRP), a 15-kDa interferon-induced protein, is a sequence homolog of ubiquitin that is covalently ligated to intracellular proteins in a parallel enzymatic reaction and is found at low levels within cultured cell lines and human tissues not exposed to interferon. Ubiquitin and UCRP ligation reactions apparently target distinct subsets of intracellular proteins, as judged from differences in the distributions of the respective adducts revealed on immunoblots. In this study, successive passages of the human lung carcinoma line A549 in the presence of neutralizing antibodies against alpha and beta interferons had no effect on the levels of either free or conjugated UCRP, indicating that these UCRP pools are constitutively present within uninduced cells and are thus not a consequence of autoinduction by low levels of secreted alpha/beta interferon. In an effort to identify potential targets for UCRP conjugation, the immunocytochemical distribution of UCRP was examined by using affinity-purified polyclonal antibodies against recombinant polypeptide. UCRP distributes in a punctate cytoskeletal pattern that is resistant to extraction by nonionic detergents (e.g., Triton X-100) in both uninduced and interferon-treated A549 cells. The cytoskeletal pattern colocalizes with the intermediate filament network of epithelial and mesothelial cell lines. Immunoblots of parallel Triton X-100-insoluble cell extracts suggest that the cytoskeletal association largely results from the noncovalent association of UCRP conjugates with the intermediate filaments rather than direct ligation of the polypeptide to structural components of the filaments. A significant increase in the sequestration of UCRP adducts on intermediate filaments accompanies interferon induction. These results suggest that UCRP may serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments.
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Loeb, K. R., and A. L. Haas. "Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern." Molecular and Cellular Biology 14, no. 12 (December 1994): 8408–19. http://dx.doi.org/10.1128/mcb.14.12.8408-8419.1994.
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Ubiquitin cross-reactive protein (UCRP), a 15-kDa interferon-induced protein, is a sequence homolog of ubiquitin that is covalently ligated to intracellular proteins in a parallel enzymatic reaction and is found at low levels within cultured cell lines and human tissues not exposed to interferon. Ubiquitin and UCRP ligation reactions apparently target distinct subsets of intracellular proteins, as judged from differences in the distributions of the respective adducts revealed on immunoblots. In this study, successive passages of the human lung carcinoma line A549 in the presence of neutralizing antibodies against alpha and beta interferons had no effect on the levels of either free or conjugated UCRP, indicating that these UCRP pools are constitutively present within uninduced cells and are thus not a consequence of autoinduction by low levels of secreted alpha/beta interferon. In an effort to identify potential targets for UCRP conjugation, the immunocytochemical distribution of UCRP was examined by using affinity-purified polyclonal antibodies against recombinant polypeptide. UCRP distributes in a punctate cytoskeletal pattern that is resistant to extraction by nonionic detergents (e.g., Triton X-100) in both uninduced and interferon-treated A549 cells. The cytoskeletal pattern colocalizes with the intermediate filament network of epithelial and mesothelial cell lines. Immunoblots of parallel Triton X-100-insoluble cell extracts suggest that the cytoskeletal association largely results from the noncovalent association of UCRP conjugates with the intermediate filaments rather than direct ligation of the polypeptide to structural components of the filaments. A significant increase in the sequestration of UCRP adducts on intermediate filaments accompanies interferon induction. These results suggest that UCRP may serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments.
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López de Guereñu, Anna, Philipp Bastian, Pablo Wessig, Leonard John, and Michael U. Kumke. "Energy Transfer between Tm-Doped Upconverting Nanoparticles and a Small Organic Dye with Large Stokes Shift." Biosensors 9, no. 1 (January 8, 2019): 9. http://dx.doi.org/10.3390/bios9010009.
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Lanthanide-doped upconverting nanoparticles (UCNP) are being extensively studied for bioapplications due to their unique photoluminescence properties and low toxicity. Interest in RET applications involving UCNP is also increasing, but due to factors such as large sizes, ion emission distributions within the particles, and complicated energy transfer processes within the UCNP, there are still many questions to be answered. In this study, four types of core and core-shell NaYF4-based UCNP co-doped with Yb3+ and Tm3+ as sensitizer and activator, respectively, were investigated as donors for the Methyl 5-(8-decanoylbenzo[1,2-d:4,5-d′]bis([1,3]dioxole)-4-yl)-5-oxopentanoate (DBD-6) dye. The possibility of resonance energy transfer (RET) between UCNP and the DBD-6 attached to their surface was demonstrated based on the comparison of luminescence intensities, band ratios, and decay kinetics. The architecture of UCNP influenced both the luminescence properties and the energy transfer to the dye: UCNP with an inert shell were the brightest, but their RET efficiency was the lowest (17%). Nanoparticles with Tm3+ only in the shell have revealed the highest RET efficiencies (up to 51%) despite the compromised luminescence due to surface quenching.
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Motohashi, Nobuyoshi, Takayuki Kuroda, Leopoldino Capelozza Filho, and José Alberto De Souza Freitas. "P-A Cephalometric Analysis of Nonoperated Adult Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 31, no. 3 (May 1994): 193–200. http://dx.doi.org/10.1597/1545-1569_1994_031_0193_pacaon_2.3.co_2.
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P-A cephalometric analysis was performed on the craniofacial morphology in 88 Brazilian men with nonoperated and operated cleft lip and palate. For the comparative study, these subjects were divided into the following four groups: (1) 31 nonoperated unilateral cleft lip and palate (UCLP), (2) 24 nonoperated bilateral cleft lip and palate (BCLP), (3) 16 operated UCLP, (4) 17 operated BCLP. Thirty Brazilian men without cleft lip and palate were used as control subjects. In comparison with the control subjects, nonoperated BCLP and UCLP showed remarkable facial deformity characterized by Increased width of various facial parts. Facial morphology of surgically treated BCLP and UCLP, however, was very similar to that of noncleft subjects, apart from the Immediate cleft region. There was no remarkable difference in the facial morphology between nonoperated BCLP and UCLP, except for the cleft width and the deviation of nasal septum base, while the only significant difference between operated BCLP and UCLP was in the cleft width.
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Bednar, Katy A., David S. Briss, Mohamed S. Bamashmous, Barry H. Grayson, and Pradip R. Shetye. "Palatal and Alveolar Tissue Deficiency in Infants With Complete Unilateral Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 55, no. 1 (December 14, 2017): 64–69. http://dx.doi.org/10.1177/1055665617718545.
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Objective: To investigate intrinsic palatal and alveolar tissue deficiency in patients with unilateral cleft lip and palate (UCLP) as compared to age-matched individuals without UCLP using surface area measurements on 3D scans of plaster casts. Methods: 22 maxillary casts of infants with UCLP from the Wyss Department of Plastic Surgery of NYU Langone Medical Center and 37 maxillary casts from infants without clefts from Sillman’s longitudinal study were scanned by Ortho Insight 3D by Motion View Software, LLC (Chattanooga, TN) and measured using Checkpoint software (Stratovan, Davis, CA). The palatal and alveolar surface areas of each cast were measured. The most superior point of the alveolar ridge in front of the incisive papilla and the most superior point of each maxillary tuberosity were connected by a line that ran along the highest part of the alveolar ridge. This line was used to set boundaries for the palatal surface area measurements. The surface areas of greater and lesser segments were measured independently on UCLP casts. A total palatal surface area for the UCLP sample including width of the cleft gap was also measured. Results: There was a statistically significant difference in surface area ( P > .001) when we compared the UCLP area of the cleft segments alone with the non-cleft sample. There was a positive correlation (determine the statistical significance) between the surface area of the cleft segments and cleft gap. In addition, there was a statistically significant difference between UCLP plus cleft area and the non-cleft samples in surface area ( P < .0001). Conclusion: An intrinsic palatal and alveolar tissue deficiency exists in patients born with UCLP. The amount of tissue deficiency for a patient with UCLP should be considered when developing and executing a patient-specific treatment plan.
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Batwa, Waeil, Khalid Almoammar, Aziza Aljohar, Abdullah Alhussein, Saad Almujel, and Khalid H. Zawawi. "The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients." BioMed Research International 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/5405376.
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Objective. The aim was to evaluate differences in the cervical vertebral skeletal maturity of unilateral cleft lip and palate (UCLP) and non-cleft lip/palate (non-CLP) Saudi male orthodontic patients. Method. This cross-sectional multicenter study took place at the dental school, King Saud University and King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, between October 2014 and September 2015. The records of Saudi male orthodontic patients with UCLP n=69 were collected. Cervical vertebral maturation was assessed using their cephalometric radiographs. The records of 138 age-matched non-CLP Saudi male orthodontic patients served as controls. Results. There was a significant difference in skeletal maturity between the UCLP and non-CLP groups, as evident in the delayed skeletal development among the UCLP participants. Moreover, pubertal growth spurt onset was significantly earlier in the non-cleft participants in comparison with the UCLP participants p=0.009. Conclusions. There is delayed skeletal maturity among the UCLP Saudi male population in comparison with their non-CLP age-matched peers.
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Kyrkanides, Stephanos, and Liubov Richter. "Mandibular Asymmetry and Antigonial Notching in Individuals with Unilateral Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 39, no. 1 (January 2002): 30–35. http://dx.doi.org/10.1597/1545-1569_2002_039_0030_maaani_2.0.co_2.
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Objective To determine whether asymmetric antigonial notching is associated with the development of mandibular and lower facial asymmetry in individuals with unilateral cleft lip and palate (UCLP). Design Retrospective mixed-longitudinal investigation including UCLP and nonaffected orthodontic patients. Participants All (24) available patients with UCLP treated in our clinic with complete longitudinal records, and 72 skeletal maturation matched noncleft orthodontic patients that served as controls. Subject records included hand-wrist, panoramic, frontal, and 45° oblique cephalometric radiographs. Main outcome Measures The development of mandibular asymmetry, measured on oblique cephalometric radiographs, as well as lower facial asymmetry, measured on frontal cephalometric radiographs, was monitored in individuals with UCLP in relation to antigonial notching asymmetry, assessed on panoramic and oblique cephalometric radiographs. Results First, no statistical differences were found in antigonial notching asymmetry between patients with UCLP and noncleft controls. Second, antigonial notching asymmetry, observed on panoramic and oblique cephalometric radiographs, significantly correlated with the attendant development of mandibular and lower facial asymmetry in individuals with UCLP. Third, the development of mandibular and lower facial asymmetry at pubertal and post-pubertal growth spurt stages significantly correlated with antigonial notching asymmetry, measured on panoramic radiographs, at prepubertal and pubertal growth spurt stages, respectively. Conclusions The degree of antigonial notching noted on panoramic radiographs can be used as an early indicator of developing mandibular and lower facial asymmetry in individuals with UCLP.
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Wang, Shufang, and Xinlong Huo. "Comprehensive Analysis of ESRRA in Endometrial Cancer." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382199208. http://dx.doi.org/10.1177/1533033821992083.
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Background: Estrogen-related receptor alpha (ESRRA) was reported to play an important role in multiple biological processes of neoplastic diseases. The roles of ESRRA in endometrial cancer have not been fully investigated yet. Methods: Expression data and clinicopathological data of patients with uteri corpus endometrial carcinoma (UCEC) were obtained from The Cancer Genome Atlas (TCGA). Comprehensive bioinformatics analysis was performed, including receiver operating characteristics (ROC) curve analysis, Kaplan-Meier survival analysis, gene ontology (GO) enrichment analysis, and Gene Set Enrichment Analysis (GSEA). Immunohistochemistry was used to detect the protein expression level of ESRRA and CCK-8 assay was performed to evaluate the effect of ESRRA on the proliferation ability. Results: A total of 552 UCEC tissues and 35 normal tissues were obtained from the TCGA database. The mRNA and protein expression level of ESRRA was highly elevated in UCEC compared with normal tissues, and was closely associated with poor prognosis. ROC analysis indicated a very high diagnostic value of ESRRA for patients with UCEC. GO and GSEA functional analysis showed that ESRRA might be mainly involved in cellular metabolism processes, in turn, tumorigenesis and progression of UCEC. Knockdown of ESRRA inhibited the proliferation of UCEC cells in vitro. Further immune cell infiltration demonstrated that ESRRA enhanced the infiltration level of neutrophil cell and reduced that of T cell (CD4+ naïve), NK cell, and cancer associated fibroblast (CAF). The alteration of immune microenvironment will greatly help in developing immune checkpoint therapy for UCEC. Conclusions: Our study comprehensively analyzed the expression level, clinical value, and possible mechanisms of action of ESRRA in UCEC. These findings showed that ESRRA might be a potential diagnostic and therapeutic target.
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Suzuki, Akira, Mieko Watanabe, Masayuki Nakano, and Yasuhide Takahama. "Maxillary Lateral Incisors of Subjects with Cleft Lip and/or Palate: Part 2." Cleft Palate-Craniofacial Journal 29, no. 4 (July 1992): 380–84. http://dx.doi.org/10.1597/1545-1569_1992_029_0380_mliosw_2.3.co_2.
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Maxillary lateral incisors on the alveolar cleft were investigated in 431 cleft children registered in the Department of Orthodontics, Kyushu University Dental Hospital. The majority of primary maxillary lateral incisors were located on the distal side of the alveolar cleft in both unilateral cleft lip and alveolus (UCLA) and unilateral cleft lip and palate (UCLP) subjects. Permanent teeth in UCLA tend to be located distally, but in UCLP they tend to be congenially absent (p < .01). The majority of primary teeth had normal shapes; the majority of permanent teeth were of intermediate type or were missing congenially. One third of the UCLA and one half of the UCLP subjects who had primary maxillary lateral incisors were not followed by permanent replacements. The location of the majority of permanent maxillary lateral incisors tallied with that of the primary ones except in four UCLA, ten UCLP, and two bilateral cleft lip and palate (BCLP) subjects. Four UCLA and ten UCLP subjects who had primary lateral incisors on the distal side were followed by their permanent successors on the mesial side. Three UCLP and one BCLP subjects had permanent maxillary lateral incisors even though they had no temporary predecessors.
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Laspos, Christodoulos P., Stephanos Kyrkanides, Ross H. Tallents, Mark E. Moss, and J. Daniel Subtelny. "Mandibular Asymmetry in Noncleft and Unilateral Cleft Lip and Palate Individuals." Cleft Palate-Craniofacial Journal 34, no. 5 (September 1997): 410–16. http://dx.doi.org/10.1597/1545-1569_1997_034_0410_mainau_2.3.co_2.
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Objective: The purpose of this study was to retrospectively investigate mandibular asymmetry in unilateral cleft lip and palate individuals (UCLP) in relation to chronologic age and in relation to lower facial asymmetry. Design: The longitudinal records of 34 UCLP individuals and 142 controls treated in the Department of Orthodontics, Eastman Dental Center, Rochester, NY, were included in the study. Posteroanterior and oblique cephalometric radiographs were analyzed for lower facial asymmetry and mandibular asymmetry, respectively. Mandibular asymmetry in UCLP was analyzed relative to three age groups (6–10, 11–14, and 15 or greater) and compared to controls. Moreover, mandibular asymmetry was analyzed relative to lower facial asymmetry. Results: UCLP individuals showed no significant differences in mandibular asymmetry compared to controls. In addition, no significant correlation was found between mandibular asymmetry and lower facial asymmetry in UCLP. Conclusions: The degree of mandibular asymmetry in UCLP appears not to be the major contributing factor to the lower facial asymmetry noted on these individuals. Possible cranial-base/temporal-region anomalies may be involved in unilateral cleft lip and palate and be responsible of the asymmetry noted in the lower facial skeleton.
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Aoshima, Osamu, Yoshinori Satoh, Ryuichi Imamura, and Toshiaki Yamashita. "A Study of Patients with Angle Class I Unilateral Cleft Lip and Palate (UCLP) Using Lateral Roentgenographic Cephalograms. A Comparison between Anterior Cross-Bite UCLP Patients and Anterior Cross-Bite Non-UCLP, Normal Bite UCLP or Normal Bite Non-UCLP Patients." Journal of Nihon University School of Dentistry 38, no. 2 (1996): 67–77. http://dx.doi.org/10.2334/josnusd1959.38.67.
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Akarsu-Guven, Bengisu, Jale Karakaya, Figen Ozgur, and Muge Aksu. "Upper airway features of unilateral cleft lip and palate patients in different growth stages." Angle Orthodontist 89, no. 4 (January 29, 2019): 575–82. http://dx.doi.org/10.2319/022518-155.1.
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ABSTRACT Objectives: To compare growth-related changes of skeletal and upper airway features of unilateral cleft lip and palate subjects (UCLP) with non-cleft control (NCC) subjects by using lateral cephalograms. Materials and Methods: The sample comprised 238 subjects, collected cross-sectionally, divided into 2 groups: 94 with UCLP, and 144 NCC, subdivided into 4 groups according to their growth stages by using cervical vertebral maturation stage (CVMS). The subgroups were defined as early childhood (stage 1), prepubertal (stage 2: CVMS I and II), pubertal (stage 3: CVMS III and IV), and postpubertal (stage 4: CVMS V and VI). Results: The maxilla was more retrognathic at stages 2, 3, and 4 in females with UCLP. The mandible was more retrognathic in UCLP at stage 1 in males, and stages 2 and 3 in females. ANB (angle between NA plane and NB plane) was significantly smaller in UCLP subjects at stage 4 for both sexes. A vertical growth pattern was seen in UCLP subjects except males at stages 2 and 3, and females at stage 2. Posterior airway space was significantly narrower at all stages in males and after stage 1 in females. Middle airway space was significantly wider at all stages in females and after stage 1 in males. Epiglottic airway space was significantly narrower in males at stage 3. Conclusions: Age- and sex-dependent differences in skeletal morphology and upper-airway widths of the UCLP subjects were identified when compared with controls.
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Marchioro, T. L., D. M. Martin, and W. D. Payne. "UCES: an undergraduate CSE initiative." IEEE Computational Science and Engineering 2, no. 3 (1995): 69–73. http://dx.doi.org/10.1109/99.414884.
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Forsyth, Patrick B. "Willower, the professor and UCEA." Journal of Educational Administration 39, no. 5 (October 1, 2001): 419–23. http://dx.doi.org/10.1108/eum0000000005811.
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Describes Willower’s considered and valued role as a professor and reviews aspects of his career. Notes how Willower advocated bringing the work of the practitioner and the scholar closer together and the need to blend knowledge, values, and method. These characteristics contributed to Willower’s substantial role in the foundation and continuing development of the University Council for Educational Administration.
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Grasa, Eduard, Sergi Figuerola, Albert López, Gabriel Junyent, Michel Savoie, Bill St Arnaud, and Mathieu Lemay. "Articulated private networks in UCLP." Internet Research 17, no. 5 (October 23, 2007): 535–45. http://dx.doi.org/10.1108/10662240710830226.
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Suzuki, Akira, Yo Mukai, Masamichi Ohishi, Yasuko Miyanoshita, and Hideo Tashiro. "Relationship between Cleft Severity and Dentocraniofacial Morphology in Japanese Subjects with Isolated Cleft Palate and Complete Unilateral Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 30, no. 2 (March 1993): 175–81. http://dx.doi.org/10.1597/1545-1569_1993_030_0175_rbcsad_2.3.co_2.
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Relationships between the width of the palatal cleft measured at paIatopIasty and the craniofacial morphology or the occlusal conditions present at approximately 4 years of age were studied in 25 cleft palate (CP) and 39 complete unilateral cleft lip and palate (UCLP) subjects treated at the Dental Clinic of Kyushu University. Posteroanterior cephalograms and dental casts showed that the width of the palatal cleft was significantly correlated with wider upper facial width and posterior dental arch width in UCLP, but not in CP subjects. Cleft width was not significantly correlated with the buccolingual occlusal relationship in either subject type. The anterior occlusal relationship in UCLP was not as good as in CP subjects. On lateral cephalograms, the width of the palatal cleft was significantly correlated with vertical hypoplasia of the upper face in UCLP, but not in CP subjects. The cleft palate width appears to be related to the lateral displacement and the retardation of the downward and forward growth of the nasomaxillary complex in UCLP subjects.
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Hocevar-Boltezar, I., A. Jarc, and V. Kozelj. "Ear, nose and voice problems in children with orofacial clefts." Journal of Laryngology & Otology 120, no. 4 (February 17, 2006): 276–81. http://dx.doi.org/10.1017/s0022215106000454.
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The purpose of this study was to compare the prevalence of ear, nose and particularly voice problems in groups of children with cleft palate (CP) and with unilateral cleft lip, alveolus and palate (UCLP). On the basis of history, regular otorhinolaryngological examinations and hearing tests, the prevalence of different pathologies was assessed in 80 CP children (35 boys and 45 girls) and 73 UCLP children (47 boys and 26 girls). Ear pathology was reported in 53.8 per cent of CP children and in 58.9 per cent of UCLP children. Nasal breathing was impaired in 14 CP (17.5 per cent) and 36 UCLP (49.3 per cent) children. Dysphonia was detected in 12.5 per cent of CP and 12.3 per cent of UCLP children. In 9.2 per cent of all cleft children, functional voice disorder caused a hoarse voice. Two-thirds of cleft children with functional dysphonia had protracted hearing loss. Therefore, ENT specialists must take an active role early in the treatment of children with clefts.
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Leonard, Alan G., Brian Kneafsey, Stephen Mckenna, Chris D. Johnston, Donald J. Burden, and Mike Stevenson. "A Retrospective Comparison of Craniofacial Form in Northern Irish Children with Unilateral Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 35, no. 5 (September 1998): 402–7. http://dx.doi.org/10.1597/1545-1569_1998_035_0402_arcocf_2.3.co_2.
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Objective This study evaluated the craniofacial form of a sample of Northern Irish children with unilateral cleft lip and palate (UCLP). The quality of the outcomes achieved was compared with the outcomes reported for the six centers involved in the European multicenter study (Mars et al., 1992; Mølsted et al, 1992). Design Retrospective analysis. Patients All children born with complete skeletal UCLP in Northern Ireland during the years 1983 to 1987. Main outcome Measures Cephalometric analysis was used to determine the craniofacial form and soft tissue profile. The quality of the dental arch relationships was independently assessed using the Goslon ranking system. Results The sample comprised 25 children with complete skeletal UCLP who had cephalometric radiographs and study casts recorded at a mean age of 9.4 years (range, 8 to 11 years). Cephalometric analysis revealed no important skeletal differences between the Northern Irish UCLP children and the published results from the six Eurocleft centers. The soft tissue profile of the Northern Irish UCLP children was significantly more convex than the soft tissue profile recorded for center D in the Eurocleft study. The Goslon ranking system revealed that 18 (72%) of the Northern Irish UCLP children had good or satisfactory dental arch relationships. Conclusions No clinically important differences were detected between the mean cephalometric skeletal parameters of the Northern Irish UCLP children and those published for the six cleft centers involved in the Eurocleft study. On average, the Northern Irish UCLP children were found to differ significantly from Eurocleft's center D in their soft tissue facial contour and sagittal lip profile. The quality of the dental arch relationships of the Northern Irish sample was between the best and the less good Eurocleft centers.
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Kyrkanides, Stephanos, Ron Bellohusen, and J. Daniel Subtelny. "Asymmetries of the Upper Lip and Nose in Noncleft and Postsurgical Unilateral Cleft Lip and Palate Individuals." Cleft Palate-Craniofacial Journal 33, no. 4 (July 1996): 306–11. http://dx.doi.org/10.1597/1545-1569_1996_033_0306_aotula_2.3.co_2.
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The purpose of this study was to retrospectively evaluate post-surgical asymmetries of the upper lip and nose in complete unilateral cleft lip and palate individuals using documentation collected over a period of years. Twenty-three complete unilateral cleft lip and palate subjects (UCLP) and 34 noncleft subjects who served as controls and had undergone orthodontic treatment were Included in the study. Nasal asymmetry, deviation of the tip of the nose, and the deviation of the midpoint of the vermilion border of the upper lip were compared to chronologic age and skeletal maturation in cleft subjects and controls. Comparison between cleft and control cases was also assessed. Results indicate that nasal asymmetry peaks at postpubertal growth stages in the control groups, and the difference between UCLP and controls decreases with time and maturation. The deviation of the nasal tip peaks during the pubertal growth spurt for both UCLP and controls, and the difference between UCLP and controls also decreases with time. The deviation of the midpoint of the vermilion border shows relatively small change with time and maturation, and there is no significant difference between UCLP and controls. In general, the facial asymmetries studied were not as great as expected, and the difference between UCLP and controls decreased with time, growth, and maturation.
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Ufuk Toygar, T., M. Okan Akçam, and Ayça Arman. "A Cephalometric Evaluation of Lower Lip in Patients with Unilateral Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 41, no. 5 (September 2004): 485–89. http://dx.doi.org/10.1597/03-115.1.
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Objective The aim of this study was to evaluate cephalometrically the lower lip position and area of patients with unilateral cleft lip and palate (UCLP) comparatively with Class I skeletodental normal subjects. Patients Lateral cephalometric and hand-wrist radiographs obtained from 24 patients with UCLP (mean age 12.86 years), along with 20 normal individuals (mean age 12.33 years) used as a control group, were examined. Design In addition to standard cephalometric dentofacial variables, lower lip area (superior, middle, inferior) was also measured using a digital planimeter on the lateral cephalograms. Results The superior and middle part of the lower lip areas were significantly smaller (p < .05) in the UCLP group, compared to the control group. The inferior and total lower lip areas of patients with UCLP were found to be significantly smaller than controls. The labiomental angle was also smaller (38.79 degrees). Conclusions The results suggest that the lower lip of patients with UCLP is smaller, retruded, and curved, with a deep labiomental sulcus, compared with normal individuals during puberty. Therefore, practitioners should focus not only on the upper lip of patients with UCLP but also should consider the lower lip as it was found distinct from normal individuals during puberty.
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Celikoglu, M., SK Buyuk, AE Sekerci, K. Cantekin, and C. Candirli. "Maxillary Dental Anomalies in Patients with Cleft Lip and Palate: A Cone Beam Computed Tomography Study." Journal of Clinical Pediatric Dentistry 39, no. 2 (January 1, 2015): 183–86. http://dx.doi.org/10.17796/jcpd.39.2.t623u7495h07522r.
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Objective: To compare the frequency of maxillary dental anomalies in patients affected by unilateral (UCLP) and bilateral (BCLP) cleft lip with palate and to determine whether statistical differences were present or not between cleft and normal sides in UCLP group by using cone beam computed tomography (CBCT). In addition, the frequency of those dental anomalies was compared with previous studies presenting the same population without cleft Study Design: Fifty non-syndromic patients affected by UCLP (28 patients) and BCLP (22 patients) were selected for analysis of dental anomalies by means of CBCT. The frequency of maxillary dental anomalies including tooth agenesis, microdontia of lateral incisor, ectopic eruption and impaction of canine and supernumerary tooth were examined. Pearson chi-square and Fisher's exact tests were performed for statistical comparisons. Results: All patients affected by UCLP and BCLP were found to have at least one maxillary dental anomaly. The most frequently observed dental anomaly was tooth agenesis (92.5% and 86.4%, respectively) in UCLP and BCLP groups. Tooth agenesis and canine impaction were observed more commonly in the cleft side (75.0% and 35.7%, respectively) than in the normal side (57.1% and 14.3%, respectively) in UCLP group (p≯0.05). All dental anomalies were found to be higher in both cleft groups than in general populations not affected by cleft. Conclusion: Since patients affected by UCLP and BCLP had at least one dental anomaly and higher dental anomaly frequency as compared to patients without cleft, those patients should be examined carefully prior to orthodontic treatment.
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Spauwen, Paul H. M., Widanto Hardjowasito, Jan Boersma, and Benny S. Latief. "Dental Cast Study of Adult Patients with Untreated Unilateral Cleft Lip or Cleft Lip and Palate in Indonesia Compared with Surgically Treated Patients in the Netherlands." Cleft Palate-Craniofacial Journal 30, no. 3 (May 1993): 313–19. http://dx.doi.org/10.1597/1545-1569_1993_030_0313_dcsoap_2.3.co_2.
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To determine differences in maxillary and dentoalveolar relationships between untreated and treated patients having unilateral clefts of the lip and alveolus (UCLA) or lip and palate (UCLP), dental cast assessments were done on 70 untreated adult indonesian patients (UCLA-I, UCLP-I) and 67 Dutch patients, surgically treated in infancy (UCLA-D, UCLP-D). The indonesian group consisted of 44 UCLA-I and 26 UCLP-I patients, and the Dutch group of 24 UCLA-D and 43 UCLP-D patients. In the UCLA-I patients, deformities occurred in that part of the dentoalveolar complex that surrounds the cleft. Lip repair in the UCLA-D group more frequently caused deformities in the incisor and buccal areas on the cleft side. In the UCLP-I patients, deformities were present in the incisor and cuspid areas on the cleft side. The buccal segments showed collapse both on the cleft and noncIeft sides. Lip and palate repair in the UCLP-D group caused significantly more deformities in the incisor, cuspid, and buccal areas up to the level of the first molars, both on the cleft and noncleft sides. Surgical treatment seems to cause maxillary and dentoalveolar deformities up to the first molars more frequently, but these are not as pronounced as one would expect: following the practiced surgical regimen, the deformities were usually mild. Negative effects of surgical intervention seem to be antagonized by the restored integrity of the lip and palate leading to orientation of maxillary parts and correction of tongue position, which in turn has a molding effect on the maxilla and mandible.
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Al-Fahdawi, Mahmood Abd, Marwa Abdelwahab El-Kassaby, Mary Medhat Farid, and Mona Abou El-Fotouh. "Cone Beam Computed Tomography Analysis of Oropharyngeal Airway in Preadolescent Nonsyndromic Bilateral and Unilateral Cleft Lip and Palate Patients." Cleft Palate-Craniofacial Journal 55, no. 6 (February 22, 2018): 883–90. http://dx.doi.org/10.1597/15-322.
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Objective: The objective of this study was to assess the volume, area, and dimensions of the oropharyngeal airway (OPA) in a previously repaired nonsyndromic unilateral cleft lip and palate (UCLP) versus bilateral cleft lip and palate (BCLP) patients when compared with noncleft controls using cone beam computed tomography (CBCT). Design: This was a retrospective case-control study. Setting: The Cleft Care Center and outpatient clinic that are affiliated to our faculty were the settings for the study. Participants: A total of 58 CBCT scans were selected of preadolescent individuals: 14 BCLP, 20 UCLP, and 24 age- and gender-matched noncleft controls. Variables: Variables were volume, cross-sectional area (CSA), midsagittal area (MSA), and dimensions of OPA. Statistical analysis: One-way analysis of variance and post hoc tests were used to compare variables. Statistical significance was set at P ≤ .05. Results: UCLP showed significantly smaller superior oropharyngeal airway volume than both controls and BCLP ( P ≤ .05). BCLP showed significantly larger CSA at soft palate plane and significantly larger MSA than both UCLP and controls ( P < .05). Conclusions: UCLP patients at the studied age and stage of previously repaired clefts have significantly less superior oropharyngeal airway volume than both controls and BCLP patients. This confirms that preadolescents with UCLP are at greater risk for superior oropharyngeal airway obstruction when compared with those BCLP and controls. Furthermore, BCLP patients showed significantly larger CSA at soft palate plane and MSA than both controls and UCLP patients. These variations in OPA characteristics of cleft patients can influence function in terms of respiration and vocalization.
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Jena, Ashok Kumar, Satinder Pal Singh, and Ashok Kumar Utreja. "Effects of sagittal maxillary growth hypoplasia severity on mandibular asymmetry in unilateral cleft lip and palate subjects." Angle Orthodontist 81, no. 5 (February 21, 2011): 872–77. http://dx.doi.org/10.2319/110610-646.1.
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Abstract Objective: To test the hypothesis that sagittal maxillary growth hypoplasia has no effect on mandibular asymmetry among subjects with complete unilateral cleft lip and palate (UCLP). Design: A total of 86 subjects (normal noncleft, 42; UCLP, 44) in the age range of 15 to 25 years were chosen. Normal noncleft subjects were included in Group I. Based on the severity of sagittal maxillary growth hypoplasia, subjects with UCLP were divided into two groups. Subjects with UCLP in whom the SNM angle was ≥71 degrees and the M-point to Nasion perpendicular distance was ≤−10 mm were included in Group II. Group III consisted of subjects with UCLP in whom the SNM angle was <71 degrees and the M-point to Nasion perpendicular distance was >−10 mm. The mandibular asymmetry index (condylar, ramal, and condylar+ramal), gonial angle, and depth of the antigonial notch of three groups of subjects were examined on orthopantomograms (OPGs). Results: Among Group II subjects in whom sagittal maxillary growth was near normal, ramal and condylar+ramal heights were significantly less on the cleft side than on the normal side (P < .01). Condylar, ramal, and condylar+ramal asymmetry indices were significantly greater among Group II subjects. Mandibular asymmetry indices among Group III subjects were comparable with those in Group I subjects. Conclusion: The hypothesis was rejected. The mandible was significantly asymmetrical among subjects with UCLP in whom sagittal maxillary growth was near normal, whereas the mandible was nearly symmetrical among subjects with UCLP in whom sagittal maxillary growth hypoplasia was very severe.
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Gopinath, Vellore Kannan, Ab Rani Samsudin, Siti Noor Fazliah Mohd Noor, and Hady Youssef Mohamed Sharab. "Facial profile and maxillary arch dimensions in unilateral cleft lip and palate children in the mixed dentition stage." European Journal of Dentistry 11, no. 01 (January 2017): 076–82. http://dx.doi.org/10.4103/ejd.ejd_238_16.
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ABSTRACT Objectives: The aim of this study was to evaluate the vertical and sagittal facial profile and maxillary arch width, depth, and length of patients with unilateral cleft lip and palate (UCLP) and to compare them with healthy noncleft children in the mixed dentition stage (7–13 years). Materials and Methods: This study is conducted at Hospital Universiti Sains Malaysia. UCLP group comprised 48 patients with nonsyndromic UCLP who have had the lip and palate repaired, whereas the control group comprised 48 healthy noncleft cases. The lateral cephalometrics measurements were used to determine the vertical height, sagittal depth of the face, and cranial base length and angle. Maxillary arch dimensions were measured on the study cast including arch width, depth, and length. Results: Vertical facial height and sagittal depth measurements showed a significant decrease (P < 0.05) in the mean growth pattern in UCLP group. The anterior cranial base length (S-N) was shorter in UCLP children (P < 0.001), while Ba-N length had no significant difference (P = 0.639). Nasion-Sella Tursica-Basion angle was significantly higher in the UCLP group (P = 0.016). Dental arch width with reference to canine-to-canine and first premolar-to- first premolar distance was significantly larger in control (P = 0.001). Conclusion: Mean vertical and sagittal facial dimensions in the UCLP children who do not undergo orthodontic treatment are significantly lesser in all directions of growth than healthy noncleft children. The maxillary dental arch had a normal depth but constricted in width and arch length.
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KRATKY, Dagmar, Juliane G. STRAUSS, and Rudolf ZECHNER. "Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models." Biochemical Journal 355, no. 3 (April 24, 2001): 647–52. http://dx.doi.org/10.1042/bj3550647.
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Uncoupling protein (UCP)-2 and UCP-3 are two recently discovered proteins similar to UCP-1, which regulates thermogenesis in brown adipose tissue (BAT). Whereas UCP-1 expression is restricted to BAT, UCP-2 is widely expressed. UCP-3 is found mainly in skeletal muscle and BAT. A large body of evidence exists that the expression of UCP-2 and UCP-3 in skeletal muscle of mice is regulated by feeding/fasting, and some studies have suggested that this effect might be caused by the changing concentration of plasma non-esterified fatty acids (NEFAs). In an attempt to determine whether the increased import of triacylglycerol-derived NEFAs can also affect UCP expression, we determined the mRNA levels of UCP-1, UCP-2 and UCP-3 in BAT and muscle of induced mutant mouse lines that overexpressed or lacked lipoprotein lipase (LPL) in these tissues. The expression levels of UCP-1 and UCP-2 in BAT and in skeletal and cardiac muscle respectively were not affected by variations in tissue LPL activities. In contrast, UCP-3 mRNA levels were induced 3.4-fold in mice with high levels of LPL in skeletal muscle, and down-regulated in mice that lacked LPL in skeletal muscle. The presence or absence of LPL in BAT had no effect on UCP-3 expression levels. The response of UCP-3 mRNA expression to variations in LPL activity in skeletal muscle was independent of the feeding status or of plasma NEFA concentrations. These findings indicated that NEFAs as lipolytic products of LPL-mediated triacylglycerol hydrolysis markedly affect UCP-3 expression and that increased LPL activities occurring during fasting in skeletal muscle contribute to the induction of UCP-3 expression by promoting the increased uptake of NEFAs. In addition, our results demonstrate that UCP-2 and UCP-3 are differentially regulated in response to LPL-mediated NEFA uptake in skeletal muscle of mice.
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Иванов, Афанасий, and Afanasiy Ivanov. "COMBINING OF MATERIAL STRAIN PROCESSING METHODS." Bulletin of Bryansk state technical university 2019, no. 10 (November 7, 2019): 19–24. http://dx.doi.org/10.30987/article_5db95e85a4a413.79050731.
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The purpose of the work consists in the investigation of stress-strain properties and destruction mechanism of low-alloy steel 09G2S subjected to extrusion and uniformly channel angular pressing (UCAP). The combined method of
Strain processing consists in the successive use of extrusion methods and UCAP. There is shown an example of low-alloy steel 09G2S strengthening with the use of extrusion and UCAP. There are presented data on stress-strain properties and destruction mechanism of steel 09G2S samples at uniaxial tension at the state of delivery and after strengthening. Strength increase and steel plasticity decrease is shown. On the basis of the results of fractal graphics analysis a viscous character of steel 09G2S destruction at the state of delivery and after extrusion and UCAP is defined.
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Vidal, Hubert, Dominique Langin, Fabrizio Andreelli, Laurence Millet, Dominique Larrouy, and Martine Laville. "Lack of skeletal muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects." American Journal of Physiology-Endocrinology and Metabolism 277, no. 5 (November 1, 1999): E830—E837. http://dx.doi.org/10.1152/ajpendo.1999.277.5.e830.
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Skeletal muscle uncoupling protein 2 and 3 (UCP-2 and UCP-3) mRNA levels are increased during calorie restriction in lean and nondiabetic obese subjects. In this work, we have investigated the effect of a 5-day hypocaloric diet (1,045 kJ/day) on UCP-2 and UCP-3 gene expression in the skeletal muscle of type-2 diabetic obese patients. Before the diet, UCP-2 and UCP-3 mRNA levels were more abundant in diabetic than in nondiabetic subjects. The long (UCP-3L) and short (UCP-3S) forms of UCP-3 transcripts were expressed at similar levels in nondiabetic subjects, but UCP-3S transcripts were twofold more abundant than UCP-3Ltranscripts in the muscle of diabetic patients. Calorie restriction induced a two- to threefold increase in UCP-2 and UCP-3 mRNA levels in nondiabetic patients. No change was observed in type-2 diabetic patients. Variations in plasma nonesterified fatty acid level were positively correlated with changes in skeletal muscle UCP-3L( r = 0.6, P < 0.05) and adipose tissue hormone-sensitive lipase ( r = 0.9, P < 0.001) mRNA levels. Lack of increase in plasma nonesterified fatty acid level and in hormone-sensitive lipase upregulation in diabetic patients during the diet strengthens the hypothesis that fatty acids are associated with the upregulation of uncoupling proteins during calorie restriction.