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Dissertations / Theses on the topic 'UDP-glucuronosyltransferase'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Pritchard, Michael P. "UDP-glucuronosyltransferase : purification and activities in rat and human hepatocytes." Thesis, University of Aberdeen, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332309.

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The UDP-glucuronosyltransferases (GT) represent a major family of drug-metabolising enzymes, but little is known about their multiplicity in man. The aims of this project were to purify and characterise a GT isozyme from human liver, and to investigate glucuronidation in rat and human hepatocytes, with the aim of using human hepatocytes in primary culture as an <i>in vitro</i> model for the study of human drug metabolism. Chromatofocusing of human liver microsomes produced separation of GT isozymes, providing evidence for heterogeneity. However, purification in an active form was not achieved,

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2

McCleary, Ryan J. R. "Uridinediphosphate-glucuronosyltransferase (UDP-GT) Ontogeny and PCB Effects in Galliform Birds." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/35962.

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Hepatic UDP-GTs are partly responsible for metabolism of the thyroid hormone, thyroxine (T4), in mammals, but little is known of UDP-GT activity in birds. To determine the ontogenic pattern of UDP-GT activity in precocial birds, we measured activity in Japanese quail (Coturnix japonica) liver at days 12 and 14 of the 16.5-day incubation, 3 perihatch stages and <1, 1, 4, 6, 7, 20 and 42 days posthatch. We used an enzymatic reaction with para-nitrophenol (pNP) as substrate that was validated for quail tissue. The pattern of UDP-GT development included low embryonic activity, increased activit

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3

Bendaly, Jean. "UDP-glucuronosyltransferase (UGT) genetic variants and their potential role in carcinogenesis." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000450.

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4

Schmohl, Stefan. "Transkriptionelle Aktivierung der humanen UDP-Glucuronosyltransferase Isoform-UGT1A6 durch Induktoren vom Antioxidantien-Typ." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=963784900.

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5

Gardner-Stephen, Dione Anne, and dione bourne@flinders edu au. "Transcriptional Regulation of Human UDP-Glucuronosyltransferases." Flinders University. Medicine, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081111.223136.

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The UDP-glucuronosyltransferases (UGTs) are a superfamily of enzymes that glucuronidate small, lipophilic molecules, thereby altering their biological activity and excretion. In humans, important examples of UGT substrates include molecules of both endogenous and xenobiotic origin; thus, UGTs are considered essential contributors to homeostatic regulation and an important defence mechanism against chemical insult. In keeping with both roles, UGTs are most strongly expressed in the liver, a predominant organ involved in detoxification. Rates of glucuronidation in humans are neither uniform amon

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6

Kard, Peter Somphone. "Genetic polymorphism of UDP-glucuronosyltransferase UGT2B7 and in vivo glucuronidation of oxazepam, a genotype-phenotype comparative study." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0007/MQ45553.pdf.

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7

Adiji, Olubu Adeoye. "Identification, Characterization and Engineering of UDP-Glucuronosyltransferases for Synthesis of Flavonoid Glucuronides." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1752363/.

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Flavonoids are polyphenolics compounds that constitute a major group of plant specialized metabolites, biosynthesized via the phenylpropanoid/polymalonate pathways. The resulting specialized metabolites can be due to decoration of flavonoid compounds with sugars, usually glucose, by the action of regiospecific UDP-glycosyltransferase (UGT) enzymes. In some cases, glycosylation can involve enzymatic attachment of other sugar moieties, such as glucuronic acid, galactose, rhamnose or arabinose. These modifications facilitate or impact the bioactivity, stability, solubility, bioavailability and ta

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8

Bruni, Silvia. "The effect of encapsulated hepatocytes on hyperbilirubinemia in Gunn rats characterized by a deficiency of hepatic UDP-glucuronosyltransferase activity." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28427.

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Free and microencapsulated hepatocytes in an alginate-polylysine-alginate artificial membrane (APA), were implanted intraperitoneally into the Gunn rat, the animal model for Crigler-Najjar syndrome, to reduce serum bilirubin level. Hepatocytes from guinea pigs, Wistar and Sprague-Dawley rats whether free or microencapsulated were equally effective in lowering serum bilirubin levels in the Gunn rat. Buffalo rat hepatocytes however, were immunorejected unless microencapsulated. Decrease in serum bilirubin was concomitant with the appearance of conjugated bilirubin in the bile of Gunn rats as dem

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9

Van, der Merwe Jennie. "Isolation and evaluation of the sugarcane UDP-glucose dehydrogenase gene and promoter." Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/1254.

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10

Nishihara, Mitsuhiro. "Investigation of Drug Metabolism by Non-Cytochrome P450 Enzymes and Its Clinical Relevance." Kyoto University, 2014. http://hdl.handle.net/2433/189328.

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11

Ouzzine, Mohamed. "Expression de deux isoformes d'udp-glucuronosyltransferase humaine chez e. Coli : activité enzymatique et production d'anticorps." Nancy 1, 1991. http://www.theses.fr/1991NAN10305.

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Nous avons exprimé deux isoformes actives d'udp-glucuronosyltransferase humaines (udpgt phénol et udpgt acide hyodeoxycholique) dans e. Coli en utilisant des vecteurs d'expression performants et des séquences de traduction améliorées. Nous avons ensuite exprimé des peptides représentant des domaines spécifiques de chaque isoforme en fusion avec la protéine a dans e. Coli. Nous avons purifié une de ces protéines par immunoaffinité et nous avons développé des anticorps spécifiques dirigés contre celle-ci

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12

Bernard, Pascal. "Regulation transcriptionnelle du gene de la bilirubine udp-glucuronosyltransferase par les facteurs de transcription hepatiques hnf1 et c/ebp alpha chez la souris (doctorat : pharmacologie)." Dijon, 1999. http://www.theses.fr/1999DIJOPE01.

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13

Vecchini, Françoise. "Étude de l'expression constitutive et inductible des enzymes de phase I et II dans les cellules épidermiques humaines : mécanisme de la régulation du cytochrome P4501A1." Nancy 1, 1994. http://www.theses.fr/1994NAN12102.

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14

Van, der Merwe Laurianne. "UDP-glucose: [beta]-(1-3)-glucan (paramylon) synthase from Euglena gracillis /." Link to the online version, 2007. http://hdl.handle.net/10019/722.

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15

Gao, Xue Jiao. "Study of the alterations of intestinal UDP-glucuronosyltransferases by gut dysbiosis in experimental colitis in the rat." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952497.

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16

Terrier, Nadège. "Réactivité de métabolites d'acides carboxyliques (acylglucuronides, acyl CoA) avec les UDP-glucuronosyltransférases : étude mécanistique et implications pharmacologiques." Nancy 1, 2000. http://docnum.univ-lorraine.fr/public/SCD_T_2000_0327_TERRIER.pdf.

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17

Antonio, Laurence. "Etudes mécanistiques, structurales et fonctionnelles des UDP-glucuronosyltransférases impliquées dans la conjugaison des phénols et catéchols." Nancy 1, 2002. http://www.theses.fr/2002NAN12507.

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Les UDP-glucuronosyltransférases (UGTs) représentent une famille multigénique d'enzymes responsables de la biotransfoIination de substances exogènes (médicaments) et endogènes comme la bilirubine. Ces enzymes sont principalement hépatiques mais leur présence est également détectée au niveau d'autres organes comme, le cerveau, la peau, la muqueuse nasale ou le tractus gastro-intestinal. Dans le cadre d'une étude structure fonction de ces enzymes chez l'homme et le rat, afin de mieux comprendre les évènements moléculaires de la glucuronoconjugaison, nous avons utilisé une série de molécules, les

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18

Van, der Merwe Laurianne. "UDP-glucose: β-(1-3)-glucan (paramylon) synthase from Euglena gracilis". Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/1560.

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Thesis (MSc (Plant Biotechnology))--University of Stellenbosch, 2007.<br>The photosynthetic protist Euglena gracilis synthesizes a storage carbohydrate named paramylon, a glucan consisting only of β-(1-3)-glycosidic linkages. The enzyme that produces paramylon is a glycosyltransferase commonly known as paramylon synthase (EC 2.4.1.34; UDP-glucose: 1,3-β-D-glucan 3-β-D-glucosyl transferase). This enzyme uses UDP-glucose as its main substrate. In 2001, Bäumer et al. isolated and partially purified paramylon synthase, but never presented any sequence information. Hence, the main aim of this proje

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19

Cano, Virginie. "Conception et synthèse d'inhibiteurs pour l'étude du site actif d'une UDP-glucuronosyltransférase recombinante hépatique humaine : l'UGT1*6." Nancy 1, 1997. http://www.theses.fr/1997NAN12155.

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Des molécules originales, inhibiteurs des UDP-glucuronosyltransférases, ont été conçues, synthétisées puis testées. Ces composés constituent des sondes précieuses pour explorer l'organisation des sites actifs de ce groupe de protéines impliquées dans le métabolisme des xénobiotiques, dont les médicaments, et dans celui de substances endogènes (bilirubine, acides rétinoïques,. . . ). Les molécules synthétisées, dont la structure est analogue à celle du substrat, l'acide UDPglucuronique, permettent de caractériser plus spécifiquement le domaine peptidique interagissant avec ce co-facteur. Les pr

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20

"Expression, purification and characterization of rat UDP-glucuronosyltransferase 1A8." 2006. http://library.cuhk.edu.hk/record=b5892902.

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Lau San Shing.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 113-120).<br>Abstracts in English and Chinese.<br>Title Page --- p.1<br>List of Thesis Committee --- p.2<br>Declaration Page --- p.3<br>Acknowledgements --- p.4<br>Table of Contents --- p.5<br>Abstract --- p.10<br>論文撰要 --- p.12<br>Chapter Chapter 1 --- Introduction<br>Chapter 1.1 --- Drug Metabolism --- p.14<br>Chapter 1.2 --- Glucuronidation --- p.16<br>Chapter 1.3 --- UDP-glucuronosyltransferase (UGTs)<br>Chapter 1.3.1 --- Nomenclature --- p.18<br>Chapter 1.3.2

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21

Huang, Wei-I., and 黃薇伊. "The Correlation between UDP-Glucuronosyltransferase 1A7 (UGT1A7) Genotypes and Lung Cancer." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/57059975849820468037.

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碩士<br>臺北醫學大學<br>藥學研究所<br>97<br>Lung cancer is the leading cause of cancer deaths in Taiwan. The carcinogenesis process involves activated carcinogens which lead to mutations of crucial oncogenes resulting in tumor development. UGT1A7 (UDP-glucuronosyltransferases1A7) is an important extrahepatic enzyme that detoxifies a variety of lung carcinogens. Genetic polymorphisms in UGT1A7 were shown to have decreased catalytic activity when compared to the wild-type protein and therefore implicated as a cancer risk factor. The purpose of this study was to investigate the association between genetic pol

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22

Zimmermann, Anna [Verfasser]. "Die UDP-Glucuronosyltransferase 2B7 C_tn802T (His268Tyr) bei Harnblasenkarzinompatienten / vorgelegt von Anna Zimmermann." 2008. http://d-nb.info/992044782/34.

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23

"Effects of over-expressing UDP-glucuronosyltransferase 1A1 on xenobiotic and therapeutic drug metabolism." 2006. http://library.cuhk.edu.hk/record=b5892985.

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Leung Hau Yi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 116-131).<br>Abstracts in English and Chinese.<br>Thesis Committee --- p.in<br>Acknowledgement --- p.II<br>Abstract --- p.III<br>摘要 --- p.V<br>Table of Contents --- p.VII<br>List of Figures --- p.X<br>List of Tables --- p.XIII<br>Appendix Abbreviations --- p.XIV<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Breast Cancer --- p.1<br>Chapter 1.2 --- Development of Breast Cancer --- p.2<br>Chapter 1.3 --- Risk Factors of Breast Cancer --- p.3<br>C

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24

"Modulation of cytochrome P4501A1/1B1 and UDP-glucuronosyltransferase activities by hydroxychalcones and monoterpenes." 2003. http://library.cuhk.edu.hk/record=b5896110.

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Wang Huan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 148-158).<br>Abstracts in English and Chinese.<br>TABLE OF CONTENTS --- p.I<br>LIST OF FIGURES AND TABLES --- p.VIII<br>ABSTRACT --- p.1<br>摘要 --- p.3<br>Chapter CHAPTER 1 --- GENERAL INTRODUCTION<br>Chapter I. --- The essential factors related to cancer --- p.5<br>Chapter a. --- Carcinogens --- p.5<br>Chapter b. --- Carcinogenesis pathways --- p.7<br>Chapter c. --- DNA adducts formation and breast cancer --- p.7<br>Chapter II. --- Cytochrome P450 I enzyme family --- p

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25

Schuster, Claudia [Verfasser]. "Arzneimittelinteraktionen über das humane hepatische Phase-II-Enzym UDP-Glucuronosyltransferase (UGT) / vorgelegt von Claudia Schuster." 2010. http://d-nb.info/1009612239/34.

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26

Schmohl, Stefan [Verfasser]. "Transkriptionelle Aktivierung der humanen UDP-Glucuronosyltransferase Isoform-UGT1A6 durch Induktoren vom Antioxidantien-Typ / vorgelegt von Stefan Schmohl." 2002. http://d-nb.info/963784900/34.

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27

"Cloning, expression and characterization of rat UDP-glucuronosyltransferase 1A8 (UGT1A8) and its induction by licorice extract and 18b-glycyrrhetinic acid." 2006. http://library.cuhk.edu.hk/record=b5896505.

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Lee Kai Woo.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 90-104).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.ii<br>Thesis Committee --- p.iii<br>Abstracts --- p.v<br>論文槪要 --- p.vii<br>List of figures --- p.viii<br>List of abbreviations --- p.ix<br>Chapter Chapter one --- Introduction --- p.1<br>Chapter 1.1 --- Drug metabolism and UGTs --- p.1<br>Chapter 1.2 --- Natural substrates of UGTs --- p.4<br>Chapter 1.3 --- Functions of UGT isoforms: roles of UGT polymorphisms --- p.6<br>Chapter 1.4 --- Evolutio

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28

Robotham, Scott Allen. "Evaluation of the regioselectivity of human UDP-glucuronosyltransferase isozymes with three common sub-classes of flavonoids via metal complexation and tandem mass spectrometry." 2012. http://hdl.handle.net/2152/19676.

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Based on reactions with two flavanones, three flavonols, and five flavones the regioselectivities of twelve human UDP-glucuronosyltransferase (UGT) isozymes were elucidated. The various flavonoid glucuronides were differentiated based on LC-MS/MS fragmentation patterns of [Co(II)(flavonoid – H)(4,7-diphenyl-1,10-phenanthroline)2]+ complexes generated upon post-column complexation. Glucuronide distributions were evaluated to allow a systematic assessment of the regioselectivity of each isozyme. The various UGT enzymes, including eight UGT1A and four UGT2B, displayed a remarkable range of sel

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29

Subhanová, Iva. "Katabolická dráha hemu u chronické hepatitidy C." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-327399.

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This thesis focuses on the importance of the heme catabolic pathway in chronic hepatitis C (HCV). The aim is mainly to investigate, whether expresion/activity of key enzymes of the heme catabolic pathway, heme oxygenase (HMOX) and biliverdin reductase (BLVRA) in the liver and blood (study A) or promoter variations of HMOX1 and UDP- glucuronosyltransferase (UGT1A1) (study B) may be associated with the progression of fibrosis and may also predict antiviral treatment outcome in patients chronically infected with HCV. We set up a new sensitive method to quantify HMOX activity by reduction gas chro

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30

Shiu, Tzu-Yue, and 徐祖岳. "I. The Study of Cellular MicroRNA Expression Regulated by Hepatitis C Virus Core Protein in Human Hepatoma Cell LinesII.The Investigation of the Effect of Inflammation on the Expression of Human UDP-Glucuronosyltransferase 1A1 Gene." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/41998307147172616671.

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博士<br>國防醫學院<br>醫學科學研究所<br>101<br>Chapter I. The Study of Cellular MicroRNA Expression Regulated by Hepatitis C Virus Core Protein in Human Hepatoma Cell Lines Chronic hepatitis C virus (HCV) infection contributes to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, but the molecular pathogenesis is still unclear. HCV infection has been reported to modulate cellular microRNA (miRNA) expression. HCV core protein is believed to be involved in hepatocarcinogenesis by directly and indirectly regulating gene transcription, interfering with cellular signaling pathways, and affectin

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31

Gardner-Stephen, Dione A. "Tanscriptional regulation of human UDP-glucuronosyltransferases." 2008. http://catalogue.flinders.edu.au/local/adt/public/adt-SFU20081111.223136/index.html.

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