Relevant bibliographies by topics / Ulapualide A

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  2. Dissertations / Theses

Academic literature on the topic 'Ulapualide A'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Ulapualide A"

1

Allingham, John S., Junichi Tanaka, Gerard Marriott, and Ivan Rayment. "Absolute Stereochemistry of Ulapualide A." Organic Letters 6, no. 4 (February 2004): 597–99. http://dx.doi.org/10.1021/ol036458y.

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2

Celatka, Cassandra A., and James S. Panek. "Asymmetric synthesis of a C1C19 fragment of ulapualide A." Tetrahedron Letters 43, no. 39 (September 2002): 7043–46. http://dx.doi.org/10.1016/s0040-4039(02)01553-8.

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3

Roesener, Jeffrey A., and Paul J. Scheuer. "Ulapualide A and B, extraordinary antitumor macrolides from nudibranch eggmasses." Journal of the American Chemical Society 108, no. 4 (February 1986): 846–47. http://dx.doi.org/10.1021/ja00264a052.

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4

Vincent, E., J. Saxton, C. Baker-Glenn, I. Moal, J. D. Hirst, G. Pattenden, and P. E. Shaw. "Effects of ulapualide A and synthetic macrolide analogues on actin dynamics and gene regulation." Cellular and Molecular Life Sciences 64, no. 4 (February 2007): 487–97. http://dx.doi.org/10.1007/s00018-007-6427-1.

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5

Chattopadhyay, Shital K., James Kempson, Alan McNeil, Gerald Pattenden, Michael Reader, David E. Rippon, and David Waite. "Towards a total synthesis of ulapualide A. Concise synthetic routes to the tris-oxazole ring system and tris-oxazole macrolide core in ulapualides, kabiramides, halichondramides, mycalolides and halishigamides." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (2000): 2415–28. http://dx.doi.org/10.1039/b000750l.

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Panek, James S., Richard T. Beresis, and Cassandra A. Celatka. "Studies Directed toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C26−C42 Fragment." Journal of Organic Chemistry 61, no. 19 (January 1996): 6494–95. http://dx.doi.org/10.1021/jo960531z.

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Pattenden, Gerald, Neil J Ashweek, Charles A G. Baker-Glenn, Gary M Walker, and James G K. Yee. "Total Synthesis of (−)-Ulapualide A: The Danger of Overdependence on NMR Spectroscopy in Assignment of Stereochemistry." Angewandte Chemie International Edition 46, no. 23 (June 4, 2007): 4359–63. http://dx.doi.org/10.1002/anie.200700459.

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Pattenden, Gerald, Neil J Ashweek, Charles A G. Baker-Glenn, Gary M Walker, and James G K. Yee. "Total Synthesis of (−)-Ulapualide A: The Danger of Overdependence on NMR Spectroscopy in Assignment of Stereochemistry." Angewandte Chemie 119, no. 23 (June 4, 2007): 4437–41. http://dx.doi.org/10.1002/ange.200700459.

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9

Chattopadhyay, Shital, and Gerald Pattenden. "A Convergent Synthesis of the tris-Oxazole Ring System in Ulapualide A and Related Marine Metabolites." Synlett 12, no. 12 (December 31, 2000): 1342–44. http://dx.doi.org/10.1055/s-1997-1056.

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10

Chattopadhyay, Shital K., James Kempson, Alan McNeil, Gerald Pattenden, Michael Reader, David E. Rippon, and David Waite. "ChemInform Abstract: Towards a Total Synthesis of Ulapualide A. Concise Synthetic Routes to the tris-Oxazole Ring System (XI) and tris-Oxazole Macrolide Core (XVII) in Ulapualides, Kabiramides, Halichondramides, Mycalolides, and Halishigamides." ChemInform 31, no. 48 (November 28, 2000): no. http://dx.doi.org/10.1002/chin.200048221.

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Dissertations / Theses on the topic "Ulapualide A"

1

Walker, Gary M. "The total synthesis of ulapualide A." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442288.

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Kempson, James. "A new approach to the marine natural product ulapualide A." Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/13781/.

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This thesis describes synthetic studies directed towards a second generation total synthesis of ulapualide A. Ulapualide A is an extraordinary bioactive tris-oxazole based macrolide which was isolated from the egg masses of the marine sponge Hexabranchus sanguineus and exhibits potent antifungal activity with inhibition of leukaemia cell proliferation. The Introduction to this thesis includes an overview of natural product chemistry and draws attention to the 'ulapualide' family of secondary metabolites including their isolation, biological activity, biosynthesis and structural determination. Also included is a summary of a total synthesis of ulapualide A by our research group in Nottingham, together with a review of oxazole containing natural products. The Results and Discussion section of this thesis details our general strategy for an alternative design for the synthesis of the tris-oxazole based macrolide core of ulapualide A. A synthesis of a model system exemplifying this strategy is then described, together with a detailed discussion of polyoxazole ring formation. This is followed by application of the model study to ulapualide A itself, and includes a total synthesis of the polyol C26-C41 side-chain of ulapualide A. The section concludes by describing our synthetic efforts towards the remaining chiral fragment of this natural product, the bottom-chain. The thesis concludes with an Experimental section containing full details of the preparative work completed and listing spectroscopic and analytical data for all new compounds synthesised during the study. An Appendix contains a description of contemporaneous synthetic studies carried out by Panek et al during the course of my PhD studies. X-ray crystallographic and spectroscopic data, together with reprints of publications resulting from our work are also included.
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3

Reader, Michael. "Studies towards the synthesis of the macrolide portion of ulapualide A." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294255.

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Hoffman, Thomas. "Méthodes sélectives pour la synthèse totale de produits naturels comportant des motifs azoles." Paris 6, 2009. http://www.theses.fr/2009PA066173.

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Le thème principal de cette thèse fut l'élaboration de deux méthodologies de synthèse faisant intervenir des composés de type oxazole et thiazole, ainsi que leurs utilisations dans la synthèse totale de produits naturels. Ainsi, une réaction de métathèse croisée stéreosélective impliquant des oxazoles substitués par des groupements vinyliques en position 2 et 4, et une série de partenaires de couplage oléfiniques a été développée puis utilisée comme étape clé dans la synthèse du fragment C9-C34 de l'ulapualide A et du fragment C12-C34 de mycalolide A, deux produits naturels possédant des propriétés antifongiques et cytotoxiques. En outre, un transfert organocatalysée énantiosélectif d'hydrure sur une série d'aldéhydes α,β- insaturés contenant un motif azole en position β a été développé. Cette méthodologie fut par la suite utilisée afin de contrôler le centre stéréogène C9 de l'ulapualide A. Enfin, ces deux méthodologies ont été combinées pour réaliser la synthèse totale du myxothiazole Z, un autre produit naturel possédant des propriétés antifongique et cytotoxique.
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5

Rippon, David E. "A synthetic approach to the ulapualides." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277921.

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