Relevant bibliographies by topics / Ultra-High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS)

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Ultra-High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS)'

Author: Grafiati
Published: 1 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Ultra-High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS)"

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Scendoni, Roberto, Emanuele Bury, Erika Buratti, et al. "Detection of Morphine and Opioids in Fingernails: Immunohistochemical Analysis and Confirmation with Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry." Toxics 10, no. 8 (2022): 420. http://dx.doi.org/10.3390/toxics10080420.

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This study aimed to investigate the detection of morphine in fingernails from forensic autopsies using immunohistochemistry (IHC), with confirmation by ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS). A primary antibody specific to morphine and a secondary antibody conjugated to horseradish peroxidase (HRP) was used. IHC on specimens of Subjects A and B (both drug addicts) resulted in the detection of morphine on a cell layer of the nail plate matrix. UHPLC-HRMS and GC-MS analysis showed that Subject A had a morphine concentration of 0.3
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Cao, Shanshan, Min Hu, Lingli Yang, et al. "Chemical Constituent Analysis of Ranunculus Sceleratus L. Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole-Orbitrap High-Resolution Mass Spectrometry." Molecules 27, no. 10 (2022): 3299. http://dx.doi.org/10.3390/molecules27103299.

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Ranunculus sceleratus L.(RS) has shown various pharmacological effects in traditional Chinese medicine. In our previous study, the positive therapeutic effect on α-naphthylisothiocyanate induced intrahepatic cholestasis in rats was obtained using TianJiu treatment with fresh RS. However, the chemical profile of RS has not been clearly clarified, which impedes the research progress on the therapeutic effect of RS. Herein, an ultra-high performance liquid chromatography coupled with quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) method was developed to rapidly sepa
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Tao, Ye, Yannick Rossez, Clovis Bortolus, Luminita Duma, Faustine Dubar, and Franck Merlier. "Simultaneous Quantification of Trehalose and Trehalose 6-Phosphate by Hydrophilic Interaction Chromatography/Electrospray Accurate Mass Spectrometry with Application in Non-Targeted Metabolomics." Molecules 28, no. 8 (2023): 3443. http://dx.doi.org/10.3390/molecules28083443.

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High-resolution mass spectrometry (HRMS) was coupled with ultra-high-performance liquid chromatography (UHPLC) to simultaneously quantify trehalose and trehalose 6-phosphate without derivatization or sample preparation. The use of full scan mode and exact mass analysis also makes it possible to carry out metabolomic analyses as well as semi-quantification. In addition, the use of different clusters in negative mode makes it possible to compensate for deficiencies in linearity and inerrant saturation at time-of-flight detectors. The method has been approved and validated for different matrices,
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Filatova, Daria, Oscar Núñez, and Marinella Farré. "Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry." Toxins 12, no. 4 (2020): 247. http://dx.doi.org/10.3390/toxins12040247.

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The increasing frequency of episodes of harmful algal blooms of cyanobacterial origin is a risk to ecosystems and human health. The main human hazard may arise from drinking water supply and recreational water use. For this reason, efficient multiclass analytical methods are needed to assess the level of cyanotoxins in water reservoirs and tackle these problems. This work describes the development of a fast, sensitive, and robust analytical method for multiclass cyanotoxins determination based on dual solid-phase extraction (SPE) procedure using a polymeric cartridge, Oasis HLB (Waters Corpora
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Wei, Tingting, Tianxiao Zhou, Shenping Zhang, Zhexue Quan, and Yang Liu. "Non-Targeted Lipidomics Analysis of Characteristic Milk Using High-Resolution Mass Spectrometry (UHPLC-HRMS)." Foods 14, no. 12 (2025): 2068. https://doi.org/10.3390/foods14122068.

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Milk lipids are fundamental to the nutritional quality, functional properties, and processing behavior of dairy products. In this study, we employed an untargeted lipidomics approach based on ultra-high-performance liquid chromatography coupled with ultra-high-performance liquid chromatography–high-resolution mass spectrometry (UHPLC-HRMS) to systematically characterize the lipid profiles of ten milk types from eight animal species, including camel, mare, donkey, goat, buffalo, yak, Jersey, and Holstein. A total of 640 lipid species were identified, spanning triglycerides (TGs), phospholipids
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Agostini, Marco, Donata Favretto, Caterina Renzoni, Susanna Vogliardi, and Andrea Duranti. "Characterization of URB Series Synthetic Cannabinoids by HRMS and UHPLC–MS/MS." Pharmaceuticals 16, no. 2 (2023): 201. http://dx.doi.org/10.3390/ph16020201.

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A large number of synthetic cannabinoids are included in new psychoactive substances (NPS) and constitute an open research area in analytical pharmaceutical and toxicology when methods are needed to unambiguously identify these substances and their metabolites in biological fluids. A full molecular characterization of five synthetic molecules of the URB series that is able to interact with the endocannabinoid system was achieved with a high-resolution mass spectrometry (HRMS) in positive ion electrospray ionization and collisional experiments on the protonated parent ions, obtaining characteri
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Cui, Zhifeng, Zhe Li, Weichao Dong, Lili Qiu, Jiayu Zhang, and Shaoping Wang. "Comprehensive Metabolite Identification of Genipin in Rats Using Ultra-High-Performance Liquid Chromatography Coupled with High Resolution Mass Spectrometry." Molecules 28, no. 17 (2023): 6307. http://dx.doi.org/10.3390/molecules28176307.

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Genipin, an aglycone of geniposide, is a rich iridoid component in the fruit of Gardenia jasminoides Ellis and has numerous biological activities. However, its metabolic profiles in vivo and vitro remain unclear. In this study, an effective analytical strategy based on ultra-high-performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) in positive and negative ion modes was developed to analyze and identify genipin metabolites in rat urine, blood, feces, and fecal fermentation in combination with many methods including post-collection data mining methods, high-resolutio
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Pezzatti, Julian, Víctor González-Ruiz, Julien Boccard, Davy Guillarme, and Serge Rudaz. "Evaluation of Different Tandem MS Acquisition Modes to Support Metabolite Annotation in Human Plasma Using Ultra High-Performance Liquid Chromatography High-Resolution Mass Spectrometry for Untargeted Metabolomics." Metabolites 10, no. 11 (2020): 464. http://dx.doi.org/10.3390/metabo10110464.

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Ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) is a powerful and essential technique for metabolite annotation in untargeted metabolomic applications. The aim of this study was to evaluate the performance of diverse tandem MS (MS/MS) acquisition modes, i.e., all ion fragmentation (AIF) and data-dependent analysis (DDA), with and without ion mobility spectrometry (IM), to annotate metabolites in human plasma. The influence of the LC separation was also evaluated by comparing the performance of MS/MS acquisition in combination with three co
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El-Hawary, Enas A., Ahmed Zayed, Annegret Laub, Luzia V. Modolo, Ludger Wessjohann, and Mohamed A. Farag. "How Does LC/MS Compare to UV in Coffee Authentication and Determination of Antioxidant Effects? Brazilian and Middle Eastern Coffee as Case Studies." Antioxidants 11, no. 1 (2022): 131. http://dx.doi.org/10.3390/antiox11010131.

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Coffee is a popular beverage owing to its unique flavor and diverse health benefits. The current study aimed at investigating the antioxidant activity, in relation to the phytochemical composition, of authenticated Brazilian green and roasted Coffea arabica and C. robusta, along with 15 commercial specimens collected from the Middle East. Ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-ESI–HRMS) and UV spectrometry were employed for profiling and fingerprinting, respectively. With the aid of global natural product social molecular networking (GN
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Nuzzo, Genoveffa, Emiliano Manzo, Marcello Ziaco, et al. "UHPLC-MS Method for the Analysis of the Molecular Adjuvant Sulfavant A." Applied Sciences 11, no. 4 (2021): 1451. http://dx.doi.org/10.3390/app11041451.

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A fast and sensitive method that is based on Ultra High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS) for the measurement of Sulfavant A, a molecular adjuvant with a sulfolipid skeleton, is described. The method has been validated over the linearity range of 2.5–2000 ngmL−1 using a deuterated derivative (d70-Sulfavant A) as internal standard. Chromatographic separation is based on a UHPLC Kinetex® 2.6 µm PS C18 column and a gradient of methanol in 0.32 mM ammonium hydroxide solution buffered at pH 8. The lowest limit of quantification of Sulfavan
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Dissertations / Theses on the topic "Ultra-High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS)"

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Fohet, Loélia. "Dissémination et vieillissement des particules d'usure de pneumatiques : impacts environnementaux." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0056.

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Les particules d'usure de pneumatiques (Tire and Road Wear Particles - TRWP) sont des particules issues de l'abrasion des pneus sur la route lors de leur roulage. Elles sont de plus en plus étudiées du fait de leur impact encore mal connu sur l'environnement, notamment par les molécules qu'elles peuvent relarguer. En effet, la composition de la bande de roulement, dont elles proviennent, est complexe et constitue un cocktail de produits chimiques. Lors de ces travaux de thèse, des vieillissements de ces particules ont été réalisés en conditions accélérées (photochimique et thermique) et nature
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Oshita, Daniele 1981. "Desenvolvimento e validação de método analítico para determinação de multirresíduos de agrotóxicos em morango por LC-MS/MS e comparação com UHPLC." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250530.

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Orientador: Isabel Cristina Sales Fontes Jardim<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-24T08:24:02Z (GMT). No. of bitstreams: 1 Oshita_Daniele_D.pdf: 4645263 bytes, checksum: 6628dba7b8449d1cf1f86afa3dcae9e2 (MD5) Previous issue date: 2013<br>Resumo: Este trabalho envolve o desenvolvimento, a otimização e a validação de um método analítico para determinação de multirresíduos de agrotóxicos em amostras de morango, por cromatografia líquida acoplada à espectrometria de massas sequencial (LC-MS/MS). No preparo de amos
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Arbouche, Nadia. "Aspects analytiques, cliniques et médico-judiciaires liés à l’identification de molécules à pouvoir hypoglycémiant dans les intoxications par antidiabétiques." Electronic Thesis or Diss., Strasbourg, 2022. http://www.theses.fr/2022STRAJ020.

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L'utilisation des médicaments antidiabétiques, malgré leurs fins thérapeutiques, n'est pas dénuée de risques. Le plus grand risque lié à l'utilisation de ces médicaments est l'hypoglycémie, qui peut être fatale en cas d'utilisation inappropriée. L'utilisation détournée est en fait assez bien connue à des fins criminelles de suicide et de meurtre, comme substances dopantes dans le milieu sportif (dans le cas de l'insuline) et dans le cadre des hypoglycémies factices (syndrome de Münchhausen). Dans le cadre de ma thèse, je me suis intéressé à 5 familles d'antidiabétiques oraux (sulfamides hypogl
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Ameline, Alice. "Aspects analytiques, cliniques et médico-judiciaires des nouvelles substances psychoactives." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ018/document.

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En raison de la diffusion incontrôlée sur le e-commerce, la sécurité et l’alternative légale aux stupéfiants habituels, les nouvelles substances psychoactives (NPS), d’apparition récente (2008), sont au cœur des phénomènes récents d’addiction et de décès mal expliqués. Au-delà des différents défis dans nos sociétés (prévention, législation), la capacité d’identifier les NPS dans des échantillons biologiques pour caractériser leur utilisation, présente de nombreux challenges analytiques. L’objectif principal de cette thèse a été de collecter des échantillons biologiques (sang, urine, cheveux) p
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Book chapters on the topic "Ultra-High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS)"

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Herath, I., J. Bundschuh, and P. Bhattacharya. "Ultra-High Performance Liquid Chromatography (UHPLC) hyphenated to Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for fast analysis of arsenic species in environmental and biological media." In Arsenic in the Environment: Bridging Science to Practice for Sustainable Development As2021. CRC Press, 2024. http://dx.doi.org/10.1201/9781003317395-66.

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Owen Bussey III, Robert. "Applications of Ultra High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry." In High-Performance Liquid Chromatography - New Advances and Applications [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1006638.

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Ultra High-Performance Liquid Chromatography (UHPLC) coupled with High-Resolution Mass Spectrometry (HRMS) systems allow researchers to potentially identify and quantitate semi-volatile and nonvolatile chemical constituents in aqueous samples. High-resolution mass spectrometers usually show parent compounds and their fragments with mass to charge ratios with uncertainties in the fifth decimal place, whereas low-resolution mass spectrometers only show nominal masses with uncertainties to the first decimal place. This extra information allows for more descriptive data to characterize compounds s
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Narvaez, Alfonso, Yelko Rodriguez-Carrasco, Luigi Castaldo, Luana Izzo, and Alberto Ritieni. "Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Orbitrap High-Resolution Mass Spectrometry for Multi-Residue Analysis of Mycotoxins and Pesticides in Botanical Nutraceuticals." In Mycotoxins: An Under-evaluated Risk for Human Health. Book Publisher International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/mono/978-93-5547-768-2/ch7.

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Narvaez, Alfonso, Yelko Rodriguez-Carrasco, Luigi Castaldo, Luana Izzo, Giulia Graziani, and Alberto Ritieni. "Occurrence and Exposure Assessment of Mycotoxins in Ready-to-Eat Tree Nut Products through Ultra-High Performance Liquid Chromatography Coupled with High Resolution Q-Orbitrap Mass Spectrometry." In Mycotoxins: An Under-evaluated Risk for Human Health. Book Publisher International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/mono/978-93-5547-768-2/ch9.

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Izzo, Luana, Alfonso Narvaez, Luigi Castaldo, et al. "Multiclass and Multi-residue Screening of Mycotoxins, Pharmacologically Active Substances, and Pesticides in Infant Milk Formulas through ultra-High-performance Liquid Chromatography Coupled with High-resolution Mass Spectrometry Analysis." In Mycotoxins: An Under-evaluated Risk for Human Health. Book Publisher International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/mono/978-93-5547-768-2/ch15.

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Conference papers on the topic "Ultra-High Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (UHPLC-HRMS)"

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Hajslova, Jana, Enrico Valli, Klara Navratilova, and Tullia Gallina Toschi. "Metabolic fingerprinting strategies for authentication challenge: EVOO adulterated by soft deodorized olive oil." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/qepz3229.

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Extra virgin olive oil (EVOO) is a high value commodity that might be subject of various fraudulent practices. One of them, addition of lower grade, soft-deodorized olive oil to EVOO has recently become of concern, as such adulterant detection is not an easy task. In this study, aqueous methanolic extracts of a unique set of authentic EVOOs, soft-deodorized oils and their admixtures obtained within the OLEUM EU project (http://www.oleumproject.eu/) were investigated. Using ultra-high performance liquid chromatography coupled to hybrid quadrupole time-of-flight high-resolution tandem mass spect
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Vila, Maria, Maria Dinis, Laura Ferrando-Climent, et al. "Innovative pre-feasibility studies towards the sustainable production of rare earth concentrates for self-supply in Europe." In Proceedings of XVI International Mineral Processing and Recycling Conference, Belgrade, 28-30.05.2025. University of Belgrade, Technical Faculty, Bor, 2024. https://doi.org/10.5937/imprc25709c.

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The REESOURCE project aims to develop innovative technologies for extracting rare earths in Europe to secure the continent's self-supply and the resilience of the European REE value chains. Decarbonise the extraction of European REEs and bring the EU industry to the forefront of the sustainable local sourcing of raw materials. The present work in within the scope of work package 5-Greener beneficiation approaches for Zero-Pollution mining, aiming to develop novel formulations based on environmentally friendly chemicals for both, the mineral beneficiation process of REEs and the process water t
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CODREANU, Andreea-Miruna, Valentina-Andreea CĂLMUC, Adelina Ștefania MILEA, Alin DÎRȚU, Cătălina ITICESCU, and Puiu Lucian GEORGESCU. "UHPLC-HRMS analysis of pfas in freshwater from the lower Danube area." In International congress "Research-Innovation-Inovative Entreneurship". Ion Creangă Pedagogical State University, 2024. https://doi.org/10.46727/c.13-14-10-2023.p252-253.

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Per- and polyfluoroalkyl substances (PFAS) are widely used, long lasting synthetic chemicals, components of which break down very slowly over time. This study presents the qualitative analysis of the most common 18 PFAS in freshwater samples using a Ultra-High-Performance Liquid Chromatography – High Resolution Mass Spectrometry (UHPLC-HRMS) analytical technique. The samples were collected in spring and summer of 2023 from 7 stations along the Lower Danube River. Prior to the analysis, the water samples were submitted to automated solid phase extraction (SPE). The UHPLC-HRMS system provided ex
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