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Relevant bibliographies by topics / Ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) / Dissertations / Theses

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Dissertations / Theses on the topic 'Ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS)'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Oshita, Daniele 1981. "Desenvolvimento e validação de método analítico para determinação de multirresíduos de agrotóxicos em morango por LC-MS/MS e comparação com UHPLC." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250530.

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Orientador: Isabel Cristina Sales Fontes Jardim<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-24T08:24:02Z (GMT). No. of bitstreams: 1 Oshita_Daniele_D.pdf: 4645263 bytes, checksum: 6628dba7b8449d1cf1f86afa3dcae9e2 (MD5) Previous issue date: 2013<br>Resumo: Este trabalho envolve o desenvolvimento, a otimização e a validação de um método analítico para determinação de multirresíduos de agrotóxicos em amostras de morango, por cromatografia líquida acoplada à espectrometria de massas sequencial (LC-MS/MS). No preparo de amos

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2

Lopez, Begoña Gimenez-Cassina 1984. "Análise da composição de amostras de própolis vermelha do Brasil por espectrometria de massas com ionização por eletrospray e cromatografia líquida de ultra-eficiência (UPLC-ESI-MS) e avaliação da atividade antioxidante e antimicrobiana = Analysis of the composition of samples of red brazilian propolis by mass spectrometry with electrospray ionization and ultra high performance liquid chromatography (UPLC-ESI-MS) and evaluation of the antioxidant and antimicrobial activity." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316101.

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Orientador: Alexandra Christine Helena Frankland Sawaya<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T09:51:06Z (GMT). No. of bitstreams: 1 Lopez_BegonaGimenez-Cassina_M.pdf: 5145110 bytes, checksum: e91f0a5d069796983ac9064ccc7af78c (MD5) Previous issue date: 2014<br>Resumo: A palavra própolis tem origem Grega: pro significa em defensa de, e polis significa comunidade. A própolis é usada pelas abelhas para fortalecer as paredes da colmeia e para cobrir as paredes internas e por devido a sua atividade antimicrobi

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3

Kozáková, Soňa. "Obsah adaptogenů v rostlině Schizandra chinensis." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2013. http://www.nusl.cz/ntk/nusl-216982.

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This thesis deals with the content of adaptogens in vegetable Schizandra chinensis. The theoretical part deals with the plant Schisandra chinensis, its occurrence, characteristics, uses and cultivation. Location of plants Schisandra chinensis are classified according to Köppen climate classification and compared with the climate in the Czech Republic, due to possible prediction of growing plants in the country. Further are described adaptogens (bioactive substances) contained in this plant and to methods for their extraction and analysis. The experimental part of the thesis deals with the iden

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4

Miranda, Luís Felippe Cabral. "Desenvolvimento de uma fase extratora com polímeros de impressão molecular para extração em fase sólida de Venlafaxina, O-desmetilvenlafaxina e N-desmetilvenlafaxina em amostras de plasmas e análises por cromatografia líquida de ultra eficiência acoplada à espectometria de massas em tandem (UPLC-MS/MS)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-15052015-122818/.

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A venlafaxina (VEN), em razão de sua eficácia e brandos efeitos adversos, tem sido um dos antidepressivos mais prescritos no tratamento da depressão e ansiedade. Neste trabalho, um método analítico empregando as técnicas MISPE miniaturizada e cromatografia líquida acoplada à espectrometria de massas em Tandem, foi utilizado para a determinação de VEN e seus principais metabólitos em amostras de plasma para fins de monitorização terapêutica. A fase MIP foi sintetizada via polimerização radicalar por precipitação, fazendo uso de VEN (molécula molde), ácido metacrílico (monômero funcional), etile

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5

Pouech, Charlene. "Développement de méthodologies analytiques pour l'étude de la migration depuis des contenants en matière plastique prévus pour des applications pharmaceutiques vers des solutions aqueuses et des fluides biologiques." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10118.

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6

Ameline, Alice. "Aspects analytiques, cliniques et médico-judiciaires des nouvelles substances psychoactives." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ018/document.

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En raison de la diffusion incontrôlée sur le e-commerce, la sécurité et l’alternative légale aux stupéfiants habituels, les nouvelles substances psychoactives (NPS), d’apparition récente (2008), sont au cœur des phénomènes récents d’addiction et de décès mal expliqués. Au-delà des différents défis dans nos sociétés (prévention, législation), la capacité d’identifier les NPS dans des échantillons biologiques pour caractériser leur utilisation, présente de nombreux challenges analytiques. L’objectif principal de cette thèse a été de collecter des échantillons biologiques (sang, urine, cheveux) p

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7

Fohet, Loélia. "Dissémination et vieillissement des particules d'usure de pneumatiques : impacts environnementaux." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0056.

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Les particules d'usure de pneumatiques (Tire and Road Wear Particles - TRWP) sont des particules issues de l'abrasion des pneus sur la route lors de leur roulage. Elles sont de plus en plus étudiées du fait de leur impact encore mal connu sur l'environnement, notamment par les molécules qu'elles peuvent relarguer. En effet, la composition de la bande de roulement, dont elles proviennent, est complexe et constitue un cocktail de produits chimiques. Lors de ces travaux de thèse, des vieillissements de ces particules ont été réalisés en conditions accélérées (photochimique et thermique) et nature

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8

Alabbas, Alhumaidi. "Reversed-phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry in Characterization of Glycosaminoglycans." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3547.

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Glycosaminoglycans (GAGs) are a family of linear bio-polysaccharides, which are heterogeneously modified with negatively charged sulfate and carboxylate groups. They are located on every cell surface, extracellular matrix or intracellular space in the body. GAGs are composed of alternating units of an amino sugars (glucosamine or galactosamine) and hexuronic acid/hexose (iduronic acid, glucoronic acid/ or galactose), which are linked by glycosidic bonds with different geometries. In recent years, GAGs have attracted considerable interest. GAGs play vital roles in fundamental biological process

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9

Benson, Andrew James. "High-performance liquid chromatography (HPLC) and high-performance liquid chromatography mass spectrometry (HPLC/MS) for the analysis of date rape drugs." FIU Digital Commons, 2002. http://digitalcommons.fiu.edu/etd/1602.

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The drugs studied in this work have been reportedly used to commit drug-facilitated sexual assault (DFSA), commonly known as "date rape". Detection of the drugs was performed using high-performance liquid chromatography with ultraviolet detection (HPLC/UV) and identified with high performance-liquid chromatography mass spectrometry (HPLC/MS) using selected ion monitoring (SIM). The objective of this study was to develop a single HPLC method for the simultaneous detection, identification and quantitation of these drugs. The following drugs were simultaneously analyzed: Gamma-hydroxybutyrate (GH

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10

Ansong, Godfred. "Analysis of plant polyphenols by high performance liquid chromatography/mass spectrometry and protein binding." Oxford, Ohio : Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1083081905.

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11

Adusumilli, Harika. "Separation and identification of peptides by integrated multidimensional liquid chromatography-mass spectrometry (IMDLC-MS)." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6028.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 15, 2008) Vita. Includes bibliographical references.

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12

Yu, Ke, and 余珂. "Exploring biodegradation of emerging pollutants using next generation sequencing and UPLC-MS-MS techniques." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/210615.

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This study was conducted to set up a systematic approach utilizing advantages of both wet lab and bioinformatic methodologies to study biodegradation abilities and microbial bacterial-functional relationship within bioremediation communities. Firstly, 11pharmaceuticals and personal care products (PPCPs)were selected as target chemicals for establishing an effective determination process in analyzing trace-level concentrations in the environment, and understanding the removal routes during pollutants removal process in wastewater treatment process using activated sludge. Ultra performance li

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13

Nascimento, DemÃtrius Fernandes do. "Nimodipine determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS-MS)." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=31.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A rapid, specific and highly sensitive liquid chromatography-tandem mass spectrometry method was developed to determine nimodipine in human plasma using dibucaine as the internal standard (IS) is described. The analyte (m/z 418,6 > 342,6) and IS (m/z 344,2 > 271,0) were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1v/v). Chromatography was performed on a VarianÂ Polaris C18 analytical column (3 micrometer, 50 x 2,0 mm) and pre-column SecurityguardTM C18 (4,0 x 3,0 mm). The phase mobile c

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14

Wang, Tongwen. "Hyphenated HPLC-MS technique for analysis of compositional monosaccharides of transgenic corn glycoprotein and characterization of degradation products of diazinon, fonofos and aldicarb in various oxidation systems." Diss., Rolla, Mo. : University of Missouri-Rolla, 2007. http://scholarsmine.mst.edu/thesis/pdf/WangTongwen_09007dcc804e975c.pdf.

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Thesis (Ph. D.)--University of Missouri--Rolla, 2007.<br>Vita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed April 23, 2008) Includes bibliographical references.

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15

Rocha, Cláudia Manuela Mesquita da. "Metabolic signature of lung cancer: a metabolomic study of human tissues and biofluids." Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/13957.

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Doutoramento em Química<br>This thesis reports the application of metabolomics to human tissues and biofluids (blood plasma and urine) to unveil the metabolic signature of primary lung cancer. In Chapter 1, a brief introduction on lung cancer epidemiology and pathogenesis, together with a review of the main metabolic dysregulations known to be associated with cancer, is presented. The metabolomics approach is also described, addressing the analytical and statistical methods employed, as well as the current state of the art on its application to clinical lung cancer studies. Chapter 2 provides

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Majdak, Karolina. "Microbial binding of per- and polyfluorinated alkyl substances (PFASs) : - Analysis of PFASs in microbes with ultra-performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS)." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-69080.

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Per- and polyfluorinated alkyl substances (PFASs) belong to a large group of man-made chemicals that pollute the environment. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are the most commonly found PFASs. The pollution of PFASs can be caused among others by using of aqueous fire-fighting foams (AFFFs). PFASs are persistent compounds; that can travel long distances and bioaccumulate in biota. There are several exposure routes for PFASs, but the most common are via food and drinking water. A possible way for PFASs to enter the food chain is by adsorption to microbes. I

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Nascimento, DemÃtrius Fernandes do. "Quantification of drugs with antimicrobial activity by high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS): application in studies of comparative pharmacokinetics." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7045.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Two robust, fast and sensitive methods for quantification of sulfamethoxazole (SMX), trimethoprim (TMP) and sulfadiazine (SDZ) in plasma using high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) was developed and validated. The methods involved liquid-liquid extraction with ethyl acetate using metoprolol and sulfamethoxazole as internal standards (PI). The chromatographic separations were performed using Genesis C18 column 100 x 2.1 mm, 4 microns (sulfadiazine) and Genesis C18 150 x 4.6 mm, 4 microns (S

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18

Tang, Jianhua. "Development of a Novel Gradient Chromatofocusing Tandem Mass Spectrometry Technique for the Determination of Cationic Compounds in Biofluids; Identification of Caspase 3 Cleavage Sites of NHE-1 by High Performance Liquid Chromatography-Mass Spectrometry." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1247344073.

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19

Stuart, Orville Dean. "Investigation of Phosphorylated Proteins and Peptides in Human Cerebrospinal Fluid via High-Performance Liquid Chromatography Coupled to Elemental and Molecular Mass Spectrometry." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1245823953.

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20

Arroyo-Mora, Luis. "Environmental analysis of polar herbicides in complex organic-rich matrices by high performance liquid chromatography atmospheric pressure ionization mass spectrometry (HPLC-API-MS)." FIU Digital Commons, 2003. http://digitalcommons.fiu.edu/etd/1425.

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A comprehensive forensic investigation of sensitive ecosystems in the Everglades Area is presented. Assessing the background levels of contamination in these ecosystems represents a vital resource to build up forensic evidence required to enforce future environmental crimes within the studied areas. This investigation presents the development and validation of a fractionation and isolation method for two families of herbicides commonly applied in the vicinity of the study area, including phenoxy acids like 2,4-D, MCPA, and silvex; as well as the most common triazine-based herbicides like atraz

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Sismotto, Marcela. "Desenvolvimento e validação de método analítico utilizando LC-MS/MS para determinação de macrolídeos em carne de tilápia do Nilo (Oreochomis niloticus)." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256289.

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Orientador: Felix Guillermo Reyes Reyes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-17T10:10:51Z (GMT). No. of bitstreams: 1 Sismotto_Marcela_M.pdf: 608581 bytes, checksum: 06d9dc244d3f9c3dfc7c4d6225ed5c95 (MD5) Previous issue date: 2011<br>Resumo: O resumo poserá ser visualizado no texto completo da tese digital<br>Abstract: The abstract is available with the full eletronic digital document<br>Mestrado<br>Mestre em Ciência de Alimentos

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Marin, Córdoba Roberto. "Chromium carcinogenesis characterization of DNA damaging intermediates by EPR ³¹P NMR, HPLC, ESI-MS and magnetic susceptibility /." Ohio : Ohio University, 2010. http://www.ohiolink.edu/etd/view.cgi?ohiou1261417590.

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23

Roman, Marco <1983&gt. "Development and applications of new analytical methodologies based on HPLC-ICP-MS for trace speciation analysis of selenium in biological samples." Doctoral thesis, Università Ca' Foscari Venezia, 2011. http://hdl.handle.net/10579/1099.

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New methods for the determination of seleno-proteins in human plasma/serum were developed by coupling miniaturized affinity HPLC systems to ORS-ICP-MS and ICP-SFMS detectors. A methods interlaboratory comparison allowed to provide for the first time the indicative reference concentration of individual seleno-proteins in the commercially available BCR-637 human serum. Two methods for seleno-proteins speciation in plasma/serum where applied to investigate their distribution in patients affected by type II diabetes and colorectal cancer, compared to healthy individuals. A new method was then deve

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Lai, Sin Pin. "Furan measurement in transformer oil by UV-Vis spectroscopy using fuzzy logic approach." Thesis, Curtin University, 2009. http://hdl.handle.net/20.500.11937/2342.

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An Ultraviolet to Visible (UV-Vis) spectroscopic analysis based on fuzzy logic approach has been developed for furan content measurement in transformer oil. Following the successful identification and quantification of furan derivatives in transformer oil by ASTM D5837 standard, the new approach is able to approximate the furan content more conveniently and economically. As furan concentration level would determine the absorption intensity in UV-Vis spectral range, the fuzzy logic software model developed would exploit this characteristic to aggregate the furans content level in transformer oi

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Costa, Ana Carolina de Oliveira. "Metodologias para determinação de fármacos, metabólitos e disruptores endócrinos em água de abastecimento público utilizando técnicas de separação em meio líquido (CE/UV, CE-MS, LC-MS/MS)." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46133/tde-08112010-143525/.

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Este trabalho apresenta o desenvolvimento e validação de métodos analíticos para investigar a presença de fármacos e seus metabólitos, assim como disruptores endócrinos, em amostras de águas superficiais, utilizando estratégias de \"clean up\" e enriquecimento de amostra no modo \"on line\" (\"stacking\") e \"off line\" (extração em fase sólida, SPE), em junção com técnicas de separação avançadas em meio líquido (eletroforese capilar, CE, e cromatografia a líquido, LC, com detecção UV, e seus acoplamentos com espectrometria de massas). No primeiro Capítulo são discutidos aspectos gerais sobre

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Van, Wyk Pieter-Hugo. "Novel methods of chemical speciation of Pt(IV/II) complexes in acid halide-rich solutions by ion-pair RP-HPLC coupled to ICP-OES/MS in conjunction with 195Pt NMR." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80099.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: In this work a robust reversed phase ion-pairing high performance liquid chromatographic (RP-HPLC) method has been developed for the separation, characterization and quantification of all possible [PtCl6-nBrn]2- (n = 0 – 6) and [PtCl4-nBrn]2- (n = 0 – 4) complex anions using UV-Vis detection. High resolution 195Pt NMR of more concentrated PtII/IV solutions served to validate the relevant species assignments, particularly those of the stereoisomer species, cis- and trans- [PtCl4Br2]2-, [PtCl2Br4]2- and mer- and fac-[PtCl3Br3

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Peres, Renato Garcia. "Aplicações de CE-DAD E HPLC-DAD-ESI/MS na determinação de compostos fenolicos, metilxantinas e acidos organicos em bebidas." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256157.

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Orientador: Delia B. Rodriguez-Amaya<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-08T23:31:09Z (GMT). No. of bitstreams: 1 Peres_RenatoGarcia_D.pdf: 1331591 bytes, checksum: dd871bdf16f75c9e9198ba86cdd4a2c1 (MD5) Previous issue date: 2007<br>Resumo: Considerando que os artigos de pesquisa desta tese já estão em inglês e na forma para serem enviados aos periódicos internacionais, nos quais os resumos estão restritos a 100 ou 200 palavras, nesta seção, os resumos estão apresentados com maiores detalhes para

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Anaia, Grazielle de Campos. "Determinação multirresidual de pesticidas por HPLC no contexto de exposição ocupacional." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-23012015-101815/.

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Um método para determinação de praguicidas das classes organofosforados, carbamatos, triazinas e ureias por HPLC-MS/MS em urina de pessoas expostas em decorrência de atividades agrícolas é proposto neste trabalho. O modo de eluição isocrática e gradiente em cromatografia líquida de fase reversa com a coluna Synergi Max RP (150 x 4,6 mm, 4 µm) foram experimentados para a separação dos componentes da amostra. O modo isocrático de eluição nas condições 45:55, 60:40 e 70:30 de ACN/água foram insuficientes para eluição dos componentes da amostra com fatores de retenção aceitáveis entre 0,5 e 2

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Lai, Sin Pin. "Furan measurement in transformer oil by UV-Vis spectroscopy using fuzzy logic approach." Curtin University of Technology, Department of Electrical and Computer Engineering, 2009. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=128452.

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An Ultraviolet to Visible (UV-Vis) spectroscopic analysis based on fuzzy logic approach has been developed for furan content measurement in transformer oil. Following the successful identification and quantification of furan derivatives in transformer oil by ASTM D5837 standard, the new approach is able to approximate the furan content more conveniently and economically. As furan concentration level would determine the absorption intensity in UV-Vis spectral range, the fuzzy logic software model developed would exploit this characteristic to aggregate the furans content level in transformer oi

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Mngqawa, Pamella. "Preliminary investigation of the natural contamination of agricultural crops with selected mycotoxins in northern rural South Africa (Limpopo and Mpumalanga Provinces)." Thesis, University of Western Cape, 2013. http://hdl.handle.net/11394/3456.

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>Magister Scientiae - MSc<br>Subsistence farmers may contribute significantly to food production, food security, and employment in South Africa. However poor storage practices and contamination with mycotoxins, particularly fumonisins and aflatoxins impacts adversely on production, food safety and food security. Mycotoxins are toxic natural food-borne compounds which frequently contaminate agricultural produce worldwide. They are hazardous to humans and animals and result in significant production losses for farmers. This study focused on former Bantustans in Northern South Africa, namel

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Brown, Jenelle Daria. "Development of a method for the simultaneous detection of mycotoxins in corn using supercritical fluid extraction (SFE), high performance liquid chromatography (HPLC), and electrospray-atmospheric pressure ionization/mass spectrometry (ES-API/MS) for extraction, separation, and identification." Thesis, University of Iowa, 1999. https://ir.uiowa.edu/etd/2802.

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Lindholm, Johan. "Development and Validation of HPLC Methods for Analytical and Preparative Purposes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4442.

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Kopec, Rachel Elizabeth. "Bioavalability, Metabolism, and Bioefficacy of Tomato Carotenoids." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354735735.

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Benešová, Markéta. "Stanovení léčiv pomocí HPLC s různými typy detektorů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-216704.

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This diploma thesis deals with the determination of macrolide antibiotics in wastewater, especially with erythromycin, clarithromycin and roxithromycin. In this time are these pharmaceuticals prescribed quite frequently. Solid phase extraction (SPE) was used for the isolation and the purification of selected analytes from an aqueous matrix; as the suitable procedure was found the using Oasis HLB cartridges. High performance liquid chromatography with mass spectrometry detection (HPLC-MS) was optimized for its analysis of selected pharmaceuticals. The optimized method was used for the determina

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Šima, Aleš. "Hodnocení zátěže životního prostředí perfluorovanými sloučeninami." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-216729.

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The most important substances of the group of perfluorinated compounds are perfluorooctyl sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorooctane sulphonamide (FOSA). Perfluorinated compounds have special physical and chemical properties, which make them valuable for usage in different industrial branches. These properties, which make them so useful are also the reason, why they are so harmful for the environment. The target of theoretical part of the diploma thesis was processing of literature searche on the topic: Evaluation of environmental load by perfluorinated compounds. In t

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Kocic, Danijela. "Ultra-high throughput HPLC-MS analysis using active flow technology." Thesis, 2015. http://hdl.handle.net/1959.7/uws:46034.

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High through-put analysis is increasingly in demand in many aspects of the analytical world. In concert with the need for high throughput, there is the need for higher sensitivity and better resolution. Further, for complex mixtures there is the need often there is a requirement for comprehensive sample characterization. These requirements are the driving forces for continuous developments in instrumentation. High performance liquid chromatography with mass spectrometry detection quickly evolved from predominantly university researcher environments to a tool that is now utilised on an everyday

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KYRIAKOU, CHRYSTALLA. "Method development and validation for the determination of 49 new psychoactive substances (NPS) in serum, urine and hair by ultra-high performance liquid chromatography - tandem mass spectrometry (UHPLC-MS/MS): application to real samples." Doctoral thesis, 2018. http://hdl.handle.net/11573/1066864.

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Detection of new psychoactive substances (NPS), both in conventional and nonconventional biological samples, represents a hard challenge for forensic toxicologists. The number of newly NPS, increases each year. As soon as NPS are scheduled, new derivatives appear in the market. Despite the increasing number of NPS and the fact that fatal and acute intoxication cases have been already attributed to this novel class of compounds this phenomenon appears to be considerably underestimated, mainly due to the substantial lack of comprehensive screening methods for their detection in biological

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(7013258), Tse-Hong Chen. "Polymer-Shell Bonded Phase for Improving Online LC-MS Analysis of Intact Proteins, mAbs, and ADCs." Thesis, 2019.

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<p>LC-MS of protein drugs requires new ideas in bonded phase design rather than adapting bonded phases from the realm of small-molecule drugs. The polymer-shell bonded phase is designed to interact with larger molecules and to shield proteins from the silica substrate. The particles consist of a core of solid silica and a shell of dense polymer brush. The polymer layer is thick enough to protect the protein from interactions with silanols to reduce peak tailing. The polymer contains multiple functional groups that introduce more selectivity. This design gives unprecedented LC resolution and MS

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Havelková, Eva. "Využití moderních separačních a spektrometrických metod k identifikaci lipidomu z biologického vzorku." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-324656.

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Modern separation and spectrometric techniques for biological sample lipidom investigation Due recent progress in field of mass spectrometry the lipidomics, part of metabolomics, is increasing its importance for broad fields of biological study. The aim of this study is to test the lipid extraction techniques and to optimize the preseparation and separation of lipids suitable for mass spectrometry detection. The fragmentation patterns of four, the most abundant lipid classes of glycerolipids (PC, PE, TG, DG), were acquired for the proposed system. These patterns were compared with literature.

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Pereira, Inês. "Steroid hormones liquid chromatography-tandem mass spectrometry analysis in endometriosis." Master's thesis, 2013. http://hdl.handle.net/10451/29306.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Endometriosis is characterized by the presence of endometriotic epithelium and stroma in ectopic locations. It has been proposed that this tissue can synthesize its own growth-supporting steroid hormones by collecting substrate steroids from blood supply or by using cholesterol. In the present work Trilostane, an 3β-hydroxysteroid dehydrogenase inhibitor, was tested. The analytical part was based on High pressure Liquid Chromatography-tandem Mass Spectrometry analysis with a re

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Haung, Zong-Chih, and 黃宗智. "Analysis of biological fluids proteins by high-performance liquid chromatography / electrospray ionization mass spectrometry（HPLC/ESI/MS）." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/61280904500244117846.

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"HPLC-MS analysis of radix astragali, cortex phellodendri, rhizoma coptidis and sanhuang xiexin decoction /cTsai, Sam Hip." Thesis, 2007. http://library.cuhk.edu.hk/record=b6074521.

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A method is presented for the simultaneous identification of nine compounds in samples of A. membranaceus and A. membranaceus var. mongholicus. Compounds identified in the extracts of the two plants included glycosides, saponins and flavonoids. They are identified as Calycosin-7-O-beta-D-glucoside (C1), Ononin (C2), (6aR,11aR)-3-hydroxy- 9,10-dimethoxypterocarpan-3-O-beta-D-glucoside (C3), (3R)-7,2'-dihydr- oxy-3',4'-dimethoxyisoflavan-7-O-beta-D-glucoside (C4), Calycosin (C6), Astragaloside IV (C5 ), Formononetin (C7), (6aR,11a R)-3-hydroxy-9,10-di-methoxypterocarpan (C8), and Isomucronu

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Plozza, Timothy Edward. "The analysis of fat-soluble vitamins in dairy cow milk by high performance liquid chromatography-ion trap mass spectrometry." Thesis, 2017. https://vuir.vu.edu.au/36958/.

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Fat-soluble vitamins A, D, E, and vitamin A precursor β-carotene are essential nutrients for the human body. The analysis of these compounds is difficult due to low levels (ppt - ppm), and physical and chemical similarity to other compounds present in foods. Traditionally, the determinative step uses high performance liquid chromatography (HPLC) coupled to either ultraviolet-visible (A, D, E and β-carotene) or fluorescence (A and E) detection. The work described in this thesis demonstrates that HPLC coupled with mass spectrometry (MS) is a viable alternative due to its superior selectiv

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Sun, Tao. "Mass Spectrometry Applied to Problems in Lipid Biochemistry: Microchip Based Approach for Lipidomics Profiling and Analysis of Lipid Metabolites by LC-MS/MS." 2012. http://digital.library.duq.edu/u?/etd,154097.

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Lipidomics and metabolomics are powerful tools for the examination of cellular metabolism and physiology. Methods for lipid analysis need to be developed that begin with small samples and do not overly dilute or disperse the sample in the separation process. Microchips provide a platform for interfacing lysis of small cell populations with on-chip solid phase extraction for isolating lipid samples to generate high quality mass spectra from very small samples. Chapter 1 of this dissertation presents a novel method for small scale lipidomics of bacterial cells by microchip based extraction co

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Vrobel, Ivo. "Stanovení acetylcholinu pomocí LC-MS ve vzorcích mozkových mikrodialyzátů LC-MS/MS." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-330085.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Ivo Vrobel Supervisors: Prof. RNDr. Petr Solich, CSc; Department of Analytical Chemistry, Faculty of Pharmacy, Charles University in Prague Prof. Seppo Auriola, MSc.(Chem.) Marko Lehtonen; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Eastern Finland in Kuopio Title of master's thesis: LC-MS/MS analysis of acetylcholine in brain microdialysis samples Novel fast and simple LC-MS/MS method of ACh quantification in brain microdialysis samples utilizing stabl

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Talebi, M. "New stationary phases for high‐performance liquid chromatography of biomolecules." Thesis, 2013. https://eprints.utas.edu.au/17162/2/Whole-Talebi-thesis-2013.pdf.

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This work presents a study on the preparation and application of polymer monoliths for the liquid chromatography of biomolecules with a focus on the ion‐exchange (IEX) mode. As one important application of polymer monoliths in bioanalysis, charge heterogeneity profiling of monoclonal antibodies (mAbs) in different biopharmaceuticals was performed by developing an elution approach based on shallow pH gradient, generated using single component buffer systems as eluents through cation‐exchange (CEX) monoliths as stationary phases. A useful selection of small molecule buffer species is described

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Březinová, Marie. "Cílená analýza větvených esterů mastných kyselin pomocí LC/MS." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-351495.

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Lipidomics as a part of metabolomics is a fast-growing area of research due to the improvement in analytical techniques. This master thesis is focused on lipid extraction techniques optimization, using liquid liquid extraction and solid phase extraction as pre-separation methods and ultra performance liquid chromatography coupled with mass spectrometry for extraction and subsequent identification of branched-chain fatty acid esters (FAHFA - branched-chain Fatty Acid esters of Hydroxy Fatty Acids). This newly discovered class of lipid molecules is associated with insulin secretion, which could

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King, Siang Goh, and 吳欽翔. "Comparison and Identification of venomous components between Eastern and Western Taiwan Cobra (Naja atra) by Two Dimensional High Performance Liquid Chromatography (2D-HPLC) and Electrospray Ionization Mass Spectrometry (ESI-MS)." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/22065247906034960561.

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碩士<br>國立清華大學<br>生命科學系<br>91<br>Eastern and western Taiwan Cobra (Naja atra) have been shown differences in morphology and toxicity, but the venomous components between them still remain obscure. Here we used two dimensional (Cation exchange and Reverse pharse) high performance liquid chromatography (2D-HPLC) and electrospray ionization mass spectrometry (ESI-MS) to identify and compare the venomous components between eastern and western Taiwan cobra. Molecular weight of 40 venomous proteins were determined, 12 of them were identified. A new cysteine-rich secretory protein (CRISP) with 24940 M.

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Rabieh, Sasan [Verfasser]. "Arsenic speciation in biological samples using high performance liquid chromatography (HPLC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) and investigation of cellular uptake capabilities of arsenicals in different cell lines / von Sasan Rabieh." 2007. http://d-nb.info/986354570/34.

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Lu, W. "Biological and behavioural markers of smoking reduction." Thesis, 2017. https://eprints.utas.edu.au/27352/1/Lu_whole_thesis.pdf.

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Tobacco harm reduction involves strategies designed to reduce the harms associated with tobacco use, for example by cutting down cigarette consumption and thereby reducing exposure to the risks associated with smoking. In addition to potentially reducing the harms of continued smoking, there is evidence that some harm reduction strategies are positively associated with quitting smoking entirely. A variety of interventions exist that can be used to aid both cessation and smoking reduction. However, there are limitations with using current treatments, with most attempts to change smoking behavio

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