Relevant bibliographies by topics / Ultrasmall silica nanoparticle

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  1. Journal articles
  2. Dissertations / Theses
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Academic literature on the topic 'Ultrasmall silica nanoparticle'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Ultrasmall silica nanoparticle"

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He, Yongju, Chuan-Cun Shu, Yu Guo, Mengqiu Long, and Hui Xu. "Visualizing ultrasmall silica–CTAB hybrid nanoparticles for generating high photoluminescence." Journal of Materials Chemistry C 8, no. 19 (2020): 6413–21. http://dx.doi.org/10.1039/d0tc00797h.

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Yoo, Barney, Kai Ma, Li Zhang, et al. "Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization." Bioorganic & Medicinal Chemistry 23, no. 22 (2015): 7119–30. http://dx.doi.org/10.1016/j.bmc.2015.09.050.

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Madajewski, Brian, Feng Chen, Barney Yoo, et al. "Molecular Engineering of Ultrasmall Silica Nanoparticle–Drug Conjugates as Lung Cancer Therapeutics." Clinical Cancer Research 26, no. 20 (2020): 5424–37. http://dx.doi.org/10.1158/1078-0432.ccr-20-0851.

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Tran, Vu-Long, Vivek Thakare, Marco Natuzzi, et al. "Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging." Contrast Media & Molecular Imaging 2018 (November 1, 2018): 1–10. http://dx.doi.org/10.1155/2018/7938267.

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Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol. This functionalization strategy requires no other reactants or catalyzers and does not compromise the ultrasmall size of the particles. NODAGA-functionalized particle has been labeled with 64Cu isotope and injected intravenously to mice bearing TS/A carcinoma tumor for biodistribution study to demonstrate its potential as a bimodal MRI/PET imaging agent. A fully integrated MRI/PET system was used to simultaneously monitor the distribution of the particle. The results showed that the functionalized particle maintained properties of a renal clearable NP which could rapidly escape through kidneys and had low retention in other organs, especially liver, even though its accumulation in the tumor was modest.
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Bradbury, Michelle S., Mohan Pauliah, Pat Zanzonico, Ulrich Wiesner, and Snehal Patel. "Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 8, no. 4 (2015): 535–53. http://dx.doi.org/10.1002/wnan.1380.

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Ma, Kai, Carlie Mendoza, Margaret Hanson, Ulrike Werner-Zwanziger, Josef Zwanziger, and Ulrich Wiesner. "Control of Ultrasmall Sub-10 nm Ligand-Functionalized Fluorescent Core–Shell Silica Nanoparticle Growth in Water." Chemistry of Materials 27, no. 11 (2015): 4119–33. http://dx.doi.org/10.1021/acs.chemmater.5b01222.

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Zhu, Wei, Achraf Noureddine, Jane Y. Howe, Jimin Guo, and C. Jeffrey Brinker. "Conversion of Metal–Organic Cage to Ligand-Free Ultrasmall Noble Metal Nanocluster Catalysts Confined within Mesoporous Silica Nanoparticle Supports." Nano Letters 19, no. 3 (2019): 1512–19. http://dx.doi.org/10.1021/acs.nanolett.8b04121.

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Hinckley, Joshua A., Dana V. Chapman, Konrad R. Hedderick, Katharine W. Oleske, Lara A. Estroff, and Ulrich B. Wiesner. "Quantitative Comparison of Dye and Ultrasmall Fluorescent Silica Core–Shell Nanoparticle Probes for Optical Super-Resolution Imaging of Model Block Copolymer Thin Film Surfaces." ACS Macro Letters 8, no. 10 (2019): 1378–82. http://dx.doi.org/10.1021/acsmacrolett.9b00675.

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Wang, Xiaolei, Tieyu Cui, Fang Cui, Yajing Zhang, Da Li, and Zhidong Zhang. "Facile access to ultrasmall Eu2O3 nanoparticle-functionalized hollow silica nanospheres based on the spontaneous formation and decomposition of a cross-linked organic/inorganic hybrid core." Chemical Communications 47, no. 22 (2011): 6329. http://dx.doi.org/10.1039/c0cc05510g.

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Shi, Menghan, Jiulong Zhang, Jingchao Li, et al. "Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics." Journal of Materials Chemistry B 7, no. 3 (2019): 368–72. http://dx.doi.org/10.1039/c8tb03021a.

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Dissertations / Theses on the topic "Ultrasmall silica nanoparticle"

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Tran, Vu Long. "Synthesis, Functionalization and Characterization of Ultrasmall Hybrid Silica Nanoparticles for Theranostic Applications." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1020/document.

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Les nanoparticules (NPs) hybrides peuvent combiner les propriétés physiques uniques des éléments inorganiques pour des applications en imagerie et en thérapeutique avec la biocompatibilité des structures organiques. Cependant, leur utilisation en médecine est encore limitée par des risques potentiels de toxicité à long terme. Dans ce contexte, des NPs hybrides ultrafines pouvant être éliminées rapidement par la voie rénale apparaissent comme de bonnes candidates pour la nanomédicine. La NP à base de silice contenant des chélates du gadolinium appelée AGuIX (Activation et Guidage de l’Irradiation par rayon-X) a été développée avec un diamètre hydrodynamique de moins de 5 nm qui lui permet d’être éliminée rapidement via l’urine après injection intraveineuse. Cette NP s’est révélée être une sonde efficace en imagerie multimodale et un amplificateur local en radiothérapie pour le diagnostic et le traitement du cancer. Elle est en train d’être évaluée dans un essai clinique de phase I par radiothérapie des métastases cérébrales (NANO-RAD, NCT02820454). Néanmoins, la synthèse d’AGuIX est un procédé multi-étapes qui est difficilement modulable.Ce manuscrit rapporte, pour la première fois, le développement d’un protocole « one-pot » direct pour des nanoparticules de silice ultrafines (USNP) contenant des chélateurs complexés ou non à partir des précurseurs silanes chélatants moléculaires. Dans ce nouveau protocole, la taille des particules et les types des métaux chélatés peuvent être contrôlés facilement. Certaines des propriétés chimiques des USNP ont été clarifiées davantage pendant ce travail exploratoire. Les particules élaborées ont été caractérisées par différentes techniques analytiques complémentaires. Ces nouvelles nanoparticules USNPs présentent des caractéristiques similaires aux AGuIX en terms de propriétes biologiques et de biodistribution.Dans un second temps, un nouveau protocole de fonctionnalisation d’USNP par des précurseurs silanes chélatants a été développé. Ces chélatants libres fonctionnalisés sur la particule peuvent être alors utilisés afin de complexer des radiométaux pour l’imagerie bimodale. Enfin, d’autres stratégies de fonctionnalisation sont aussi décrites. La nouvelle sonde (17VTh031) combinant un petit chélateur cyclique (NODA) et un fluorophore proche-infrarouge tumeur ciblant (IR783) ainsi que le pyridinium quaternaire ont été greffés sur l’AGuIX pour créer une nouvelle sonde en imagerie multimodale et cibler des tumeurs chondrosarcomes respectivement<br>Hybrid nanoparticles (NPs) can combine unique physical properties for imaging and therapeutic applications of inorganic elements in bio-friendly organic structures. However, their uses in medicine are limited by the potential risks of long-term toxicities. In this context, ultrasmall renal clearable NPs appear as novel solutions. Silica based NP displaying gadolinium chelates named AGuIX (Activation and Guidance for Irradiation by X-ray) has been developed to have hydrodynamic diameter less than 5 nm which allows rapid elimination through urine after intravenous injection. This NP has been demonstrated as an efficient multimodal imaging probe and a local enhancer for radiotherapy for cancer diagnostics and treatment. It is now being evaluated in a phase I clinical trial by radiotherapy of cerebral metastases (NANO-RAD NCT02820454). Nevertheless, the synthesis of AGuIX implies a multisteps process that can be further improved.This manuscript shows, for the first time, the development of a straightforward one-pot protocol for ultrasmall silica nanoparticles (USNP) containing complexed or non-complexed chelators from molecular chelating silane precursors. In this new protocol, the size of particle and types of metals can be easily tuned. The chemical properties of USNP have been further clarified during this exploratory work. The produced particles have been characterized by different complimentary analytical techniques. These new nanoparticles USNPs show similar characteristics to AGuIX in terms of biological properties and biodistribution.Secondly, a new protocol of functionalization for USNP by chelating silane precursors has been developed. These functionalized free chelators on the particle can be used then to complex radiometals for bimodal imaging applications. Finally, other functionalization strategies have also been described. New probe (17VTh031) combining small cyclic chelator (NODA) and tumor targeting near-infrared fluorophore (IR783) as well as quaternary pyridinium have been grafted on AGuIX for creating new multimodal imaging probe and targeting chondrosarcoma tumors respectively
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Singh, Garima [Verfasser], Jörg [Gutachter] Steinbach, and Cola Luisa [Gutachter] De. "Functionalized Bispidines and Ultrasmall Silicon Nanoparticles for Cancer Imaging / Garima Singh ; Gutachter: Jörg Steinbach, Luisa De Cola." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1226942253/34.

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Singh, Garima. "Functionalized Bispidines and Ultrasmall Silicon Nanoparticles for Cancer Imaging." 2019. https://tud.qucosa.de/id/qucosa%3A34475.

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The aim of the thesis was to develop novel mono-labeled and dual-labeled imaging agents for targeting cancer tumors by Positron Emission Tomography (PET) and Optical Imaging (OI). Bispidines were used as Copper-64 and NOTA as Copper-64 as well as Gallium-68 chelators for PET. Fluorophore, IR 800 dye was used for OI. Amine-terminated ultrasmall Silicon nanoparticles (Si NPs) of size 3-5 nm were used as a multifunctional multimodal imaging core.:Chapter 1 Introduction 1 1.1 General introduction 1 1.2 Aims and objectives of the thesis 6 Chapter 2 Literature review and theoretical part 7 2.1 Molecular imaging of cancer 7 2.1.1 Positron Emission Tomography 8 2.1.2 Optical imaging 19 2.2 Multimodal molecular imaging 21 2.2.1 Silicon nanoparticles as multimodal imaging agents 23 2.2.2 Factors affecting the biodistribution and pharmacokinetics of NPs 27 2.2.3 Tumor targeting strategies for molecular imaging agents 30 2.2.4 Targeted functionalization of NPs and BFCAs for imaging purposes 32 Chapter 3 Results and Discussion 35 3.1 Synthesis, characterization and radiolabeling studies of hexadentate bispidine-based bifunctional chelating agents 37 3.1.1 Synthesis of hexadentate bispidine-based ligands 39 3.1.2 Radiochemistry of modified bispidine derivatives 59 3.1.3 Conclusions 61 3.2 Design and synthesis of Bispidine-based TATE and sd antibody bioconjugates 63 3.2.1 Bispidine-based bioconjugates of somatostatin agonist TATE 63 3.2.2 Bispidine-based EGFR targeting sdAb conjugates B5-sdAb 71 3.2.3 Conclusions 80 3.3 Synthesis and characterization of amine-terminated ultrasmall Si NPs 81 3.3.1 Synthesis of amine-terminated Si NPs 81 3.3.2 Characterization of Si NPs 82 3.3.3 Surface characterization of Si NPs 84 3.3.4 Conclusions 85 3.4 Synthesis, characterization, and biodistribution studies of Si NP-based mono-labeled PET and optical imaging agents 86 3.4.1 Si NP-NOTA derived PET imaging agent 88 3.4.2 Synthesis and characterization of Si NP-Bispidine (Si NP-B4) 93 3.4.3 Synthesis, characterization, in vitro and in vivo evaluation of Si NP-IR800 as an optical imaging probe 95 3.4.5 Conclusions 104 3.5 Development of dual-labeled Si NPs an its in vitro and in vivo evaluation 106 3.5.1 Synthesis and characterization of Si NP-IR800-NOTA conjugate 107 3.5.2 Photophysical characterization of Si NP-IR800-NOTA and comparison with mono-labeled imaging agents 109 3.5.3 Radiolabeling studies of dual-labeled Si NP-IR800-NOTA 110 3.5.4 Quantitative estimation of the amount of fluorophore and the radiolabel on the Si NP conjugate 111 3.5.5 Cell Cytotoxicity Studies of the Si NP-IR800-NOTA 114 3.5.6 In vivo PET analysis and biodistribution studies, urine analysis and ex vivo examination of [64Cu]Cu-Si NP-IR800-NOTA 115 3.5.7 Comparative analysis of [68Ga]Ga-Si NP-IR800-NOTA and [64Cu]Cu-Si NP-IR800-NOTA in A431 tumor bearing mice 121 3.5.8 Conclusions 127 3.6 Investigation of mono-labeled and dual-labeled Si NPs as targeted imaging agents 128 3.6.1 Synthesis of Si NP-PEG-5B9 peptide conjugates 128 3.6.2 Characterization of the targeted Si NP conjugates 129 3.6.3 Conclusions 134 Chapter 4 Conclusions and Outlook 135 4.1 Conclusions 135 4.2 Outlook 140 Chapter 5 Experimental Section 141 5.1 Chemicals and Materials 141 5.2 Analysis, characterization and purification techniques and methods 143 5.3 Radionuclide production (68Ga and 64Cu) 146 5.4 Syntheses 148 5.4.1 Synthesis of bispidines derivatives (B1-B11), intermediates (B1’, B3’, B8’, B9’, B11’) and bifunctional linkers (L1, L2) 148 5.4.2 Synthesis of bispidines-based bioconjugates B4-PEG-TATE and B5-sdAb-7C12 160 5.4.3 Synthesis and modification of Si NPs by hydrothermal method 161 5.5 Radiolabeling experiments 166 5.6 In vitro cell experiments 167 5.7 Cell binding studies 169 5.8 Animal experiments 170 Chapter 6 References 172 Chapter 7 Annex 192 7.1 Acronyms 192 7.2 Supplementary Data 195 Chapter 8 Publications, Conferences and Awards 203 Chapter 9 Acknowledgements 206 Chapter 10 Statement of declaration / Erklärungen 208
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Eckhoff, Dean Alan. "Optical characterization of ultrasmall, hydrogen-terminated and carboxyl-functionalized silicon nanoparticles in aqueous environments /." 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3242839.

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Thesis (Ph. D.)--University of Illinois at Urbana-Champaign, 2006.<br>Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6474. Adviser: Enrico Gratton. Includes bibliographical references (leaves 98-111). Available on microfilm from Pro Quest Information and Learning.
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Lin, Chia-Jung, and 林家榕. "Ultrasmall Palladium Nanoparticles Confined in 2D-3D Mesoporous Silica and Mesoporous Carbon Nitride for the Catalytic Organic Reaction." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ax65tu.

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碩士<br>國立中央大學<br>化學學系<br>107<br>This study consists of two main parts. In the first part, the Palladium nanoparticles (Pd NPs) with a particle size of 2-3nm are successfully confined within the 2D mesoporous silica SBA-15 and the 3D mesoporous silica KIT-6. Under the wet impregnation process, SBA-15 and KIT-6 were immersed in Pd2+ precursor and adsorbed into the pores, then. The mixture chemically reduced by reagent containing NaBH4 and NH3BH3 to obtain Pd(x)@SBA-15 and Pd(x)@KIT-6. It was found that the use of SBA-15 and KIT-6 support can highly enhance the dispersion and efficiency due to the high surface area and large pore volume. In addition, SBA-15 and KIT-6 with the pore size of 9.09 nm and 9.56 nm, respectively, may effectively confine the Pd NPs and subsequently avoid the aggregation. According to the X-ray diffraction pattern and TEM image, it can be confirmed that the particle size of Pd NPs is about 2-3 nm and highly dispersed without aggregation. The Pd(x)@SBA-15 and Pd(x)@KIT-6 exhibited superior catalytic activity and chemoselectivity for the catalytic transfer hydrogenation of styrene under mild conditions with formic acid and ammonium formate as a hydrogen donor. Among all the as-prepared catalysts, the Pd(30)@KIT-6 exhibited the highest turnover frequency (TOF) of 363 h-1. In addition, Pd(30)@KIT-6 exhibited an excellent high stability after five successive cycles without significant loss of its catalytic activity. In the second part of study, heteroatom doped carbon materials have received considerable attention in the field of catalysis. Herein, we report a catalyst made of palladium nanoparticles (Pd NPs) supported on mesoporous nitrogen-doped carbon (MUFC), Pd@MUFC. The use of the mixture of melamine-urea-formaldehyde as a precursor and the mesoporous silica SBA-15 as a hard template afforded a high-nitrogen-content mesoporous carbon material that showed high activity in stabilizing Pd NPs. The N-doped mesoporous carbon, MUFC, can provide a large surface area to adsorb the reductant and substrate, and enhance the accessibility of the active sites of the Pd NPs in the catalytic reaction process. When Pd@MUFC was applied as catalyst in the catalytic aerobic oxidation of benzyl alcohol, it achieved conversion rate and selectivity of 99.9% within 30 minutes. Among all the as-prepared catalysts, the Pd(30)@MUFC exhibited the highest turnover frequency of 750 h-1. The remarkable catalytic activity for the benzyl alcohol oxidation can be attributed to the ultra-small Pd NPs confined in the hexagonal N-doped carbonaceous MUFC.
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Book chapters on the topic "Ultrasmall silica nanoparticle"

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Nayfeh, Munir H. "Lasing Effects In Ultrasmall Silicon Nanoparticles." In Towards the First Silicon Laser. Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-010-0149-6_16.

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Bradbury, Michelle S., Mohan Pauliah, and Ulrich Wiesner. "Ultrasmall Fluorescent Silica Nanoparticles as Intraoperative Imaging Tools for Cancer Diagnosis and Treatment." In Imaging and Visualization in The Modern Operating Room. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2326-7_13.

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Conference papers on the topic "Ultrasmall silica nanoparticle"

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Yen, Te-Hsin, Yi-Shiou Duh, Yu-Lung Tang, et al. "Ultrasmall high efficency all-optical switch with single silicon nanoparticle." In Silicon Photonics XVI, edited by Graham T. Reed and Andrew P. Knights. SPIE, 2021. http://dx.doi.org/10.1117/12.2582417.

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