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1

He, Yongju, Chuan-Cun Shu, Yu Guo, Mengqiu Long, and Hui Xu. "Visualizing ultrasmall silica–CTAB hybrid nanoparticles for generating high photoluminescence." Journal of Materials Chemistry C 8, no. 19 (2020): 6413–21. http://dx.doi.org/10.1039/d0tc00797h.

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2

Yoo, Barney, Kai Ma, Li Zhang, et al. "Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization." Bioorganic & Medicinal Chemistry 23, no. 22 (2015): 7119–30. http://dx.doi.org/10.1016/j.bmc.2015.09.050.

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3

Madajewski, Brian, Feng Chen, Barney Yoo, et al. "Molecular Engineering of Ultrasmall Silica Nanoparticle–Drug Conjugates as Lung Cancer Therapeutics." Clinical Cancer Research 26, no. 20 (2020): 5424–37. http://dx.doi.org/10.1158/1078-0432.ccr-20-0851.

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4

Tran, Vu-Long, Vivek Thakare, Marco Natuzzi, et al. "Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging." Contrast Media & Molecular Imaging 2018 (November 1, 2018): 1–10. http://dx.doi.org/10.1155/2018/7938267.

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Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol. This functionalization strategy requires no other reactants or catalyzer
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5

Bradbury, Michelle S., Mohan Pauliah, Pat Zanzonico, Ulrich Wiesner, and Snehal Patel. "Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 8, no. 4 (2015): 535–53. http://dx.doi.org/10.1002/wnan.1380.

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6

Ma, Kai, Carlie Mendoza, Margaret Hanson, Ulrike Werner-Zwanziger, Josef Zwanziger, and Ulrich Wiesner. "Control of Ultrasmall Sub-10 nm Ligand-Functionalized Fluorescent Core–Shell Silica Nanoparticle Growth in Water." Chemistry of Materials 27, no. 11 (2015): 4119–33. http://dx.doi.org/10.1021/acs.chemmater.5b01222.

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7

Zhu, Wei, Achraf Noureddine, Jane Y. Howe, Jimin Guo, and C. Jeffrey Brinker. "Conversion of Metal–Organic Cage to Ligand-Free Ultrasmall Noble Metal Nanocluster Catalysts Confined within Mesoporous Silica Nanoparticle Supports." Nano Letters 19, no. 3 (2019): 1512–19. http://dx.doi.org/10.1021/acs.nanolett.8b04121.

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8

Hinckley, Joshua A., Dana V. Chapman, Konrad R. Hedderick, Katharine W. Oleske, Lara A. Estroff, and Ulrich B. Wiesner. "Quantitative Comparison of Dye and Ultrasmall Fluorescent Silica Core–Shell Nanoparticle Probes for Optical Super-Resolution Imaging of Model Block Copolymer Thin Film Surfaces." ACS Macro Letters 8, no. 10 (2019): 1378–82. http://dx.doi.org/10.1021/acsmacrolett.9b00675.

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9

Wang, Xiaolei, Tieyu Cui, Fang Cui, Yajing Zhang, Da Li, and Zhidong Zhang. "Facile access to ultrasmall Eu2O3 nanoparticle-functionalized hollow silica nanospheres based on the spontaneous formation and decomposition of a cross-linked organic/inorganic hybrid core." Chemical Communications 47, no. 22 (2011): 6329. http://dx.doi.org/10.1039/c0cc05510g.

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10

Shi, Menghan, Jiulong Zhang, Jingchao Li, et al. "Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics." Journal of Materials Chemistry B 7, no. 3 (2019): 368–72. http://dx.doi.org/10.1039/c8tb03021a.

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11

Koh, K., J. E. Seo, J. H. Lee, A. Goswami, C. W. Yoon, and T. Asefa. "Ultrasmall palladium nanoparticles supported on amine-functionalized SBA-15 efficiently catalyze hydrogen evolution from formic acid." J. Mater. Chem. A 2, no. 48 (2014): 20444–49. http://dx.doi.org/10.1039/c4ta04538f.

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12

Chandra, Prakash, Dhananjay S. Doke, Shubhangi B. Umbarkar, and Ankush V. Biradar. "One-pot synthesis of ultrasmall MoO3 nanoparticles supported on SiO2, TiO2, and ZrO2 nanospheres: an efficient epoxidation catalyst." J. Mater. Chem. A 2, no. 44 (2014): 19060–66. http://dx.doi.org/10.1039/c4ta03754e.

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13

Tran, Vu-Long, Vivek Thakare, Fabien Rossetti, et al. "One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles." Journal of Materials Chemistry B 6, no. 29 (2018): 4821–34. http://dx.doi.org/10.1039/c8tb00195b.

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14

Wang, Jiasheng, Wenpei Wu, Hongyang Ye, Yahong Zhao, Wan-Hui Wang, and Ming Bao. "MoO3 subnanoclusters on ultrasmall mesoporous silica nanoparticles: an efficient catalyst for oxidative desulfurization." RSC Advances 7, no. 71 (2017): 44827–33. http://dx.doi.org/10.1039/c7ra08566d.

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15

Yoo, B., K. Ma, U. Wiesner, and M. Bradbury. "Correction: Expanding analytical tools for characterizing ultrasmall silica-based nanoparticles." RSC Advances 8, no. 59 (2018): 34161. http://dx.doi.org/10.1039/c8ra90077a.

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16

Xu, Linxu, Jiajia Zhang, Zhenhui Li, et al. "In situ generation of ultrasmall sized and highly dispersed CuO nanoparticles embedded in silica matrix and their catalytic application." New Journal of Chemistry 43, no. 1 (2019): 520–26. http://dx.doi.org/10.1039/c8nj04517h.

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17

Yoo, B., K. Ma, U. Wiesner, and M. Bradbury. "Expanding analytical tools for characterizing ultrasmall silica-based nanoparticles." RSC Advances 7, no. 27 (2017): 16861–65. http://dx.doi.org/10.1039/c7ra01349c.

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C′ dots are fluorescent inorganic–organic hybrid nanoparticles synthesized in water comprised of a silica core with a covalently embedded near infrared dye, and a polyethylene glycol (PEG) outer layer.
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18

Wong, A., Q. Liu, S. Griffin, A. Nicholls, and J. R. Regalbuto. "Synthesis of ultrasmall, homogeneously alloyed, bimetallic nanoparticles on silica supports." Science 358, no. 6369 (2017): 1427–30. http://dx.doi.org/10.1126/science.aao6538.

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Supported nanoparticles containing more than one metal have a variety of applications in sensing, catalysis, and biomedicine. Common synthesis techniques for this type of material often result in large, unalloyed nanoparticles that lack the interactions between the two metals that give the particles their desired characteristics. We demonstrate a relatively simple, effective, generalizable method to produce highly dispersed, well-alloyed bimetallic nanoparticles. Ten permutations of noble and base metals (platinum, palladium, copper, nickel, and cobalt) were synthesized with average particle s
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19

Chen, Feng, Kai Ma, Li Zhang, et al. "Ultrasmall Renally Clearable Silica Nanoparticles Target Prostate Cancer." ACS Applied Materials & Interfaces 11, no. 47 (2019): 43879–87. http://dx.doi.org/10.1021/acsami.9b15195.

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20

Ding, Kunlun, David A. Cullen, Laibao Zhang, et al. "A general synthesis approach for supported bimetallic nanoparticles via surface inorganometallic chemistry." Science 362, no. 6414 (2018): 560–64. http://dx.doi.org/10.1126/science.aau4414.

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The synthesis of ultrasmall supported bimetallic nanoparticles (between 1 and 3 nanometers in diameter) with well-defined stoichiometry and intimacy between constituent metals remains a substantial challenge. We synthesized 10 different supported bimetallic nanoparticles via surface inorganometallic chemistry by decomposing and reducing surface-adsorbed heterometallic double complex salts, which are readily obtained upon sequential adsorption of target cations and anions on a silica substrate. For example, adsorption of tetraamminepalladium(II) [Pd(NH3)42+] followed by adsorption of tetrachlor
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21

Prajapati, Jagdish Prasad, Debjit Das, Sadhana Katlakunta, Nyathani Maramu, Vivek Ranjan, and Sadhucharan Mallick. "Synthesis and characterization of ultrasmall Cu2O nanoparticles on silica nanoparticles surface." Inorganica Chimica Acta 515 (January 2021): 120069. http://dx.doi.org/10.1016/j.ica.2020.120069.

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22

Cara, C., E. Rombi, A. Musinu та ін. "MCM-41 support for ultrasmall γ-Fe2O3 nanoparticles for H2S removal". Journal of Materials Chemistry A 5, № 41 (2017): 21688–98. http://dx.doi.org/10.1039/c7ta03652c.

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23

Sun, Bo, Tingjun Fu, and Hua Chun Zeng. "Controllable integration of ultrasmall noble metal nanoparticles into mesoporous silica matrixes by a self-assembly method." Chemical Communications 54, no. 51 (2018): 7030–33. http://dx.doi.org/10.1039/c8cc03236j.

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24

Vis, Bradley, Rachel E. Hewitt, Tom P. Monie, et al. "Ultrasmall silica nanoparticles directly ligate the T cell receptor complex." Proceedings of the National Academy of Sciences 117, no. 1 (2019): 285–91. http://dx.doi.org/10.1073/pnas.1911360117.

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The impact of ultrasmall nanoparticles (<10-nm diameter) on the immune system is poorly understood. Recently, ultrasmall silica nanoparticles (USSN), which have gained increasing attention for therapeutic applications, were shown to stimulate T lymphocytes directly and at relatively low-exposure doses. Delineating underlying mechanisms and associated cell signaling will hasten therapeutic translation and is reported herein. Using competitive binding assays and molecular modeling, we established that the T cell receptor (TCR):CD3 complex is required for USSN-induced T cell activation, and th
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25

Ma, Kai, Hiroaki Sai, and Ulrich Wiesner. "Ultrasmall Sub-10 nm Near-Infrared Fluorescent Mesoporous Silica Nanoparticles." Journal of the American Chemical Society 134, no. 32 (2012): 13180–83. http://dx.doi.org/10.1021/ja3049783.

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26

Zheng, Nanfeng, and Pengxin Liu. "Amine facilitates the synthesis of silica-supported ultrasmall bimetallic nanoparticles." Science China Materials 61, no. 8 (2018): 1129–31. http://dx.doi.org/10.1007/s40843-018-9213-4.

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27

Ferreira, Carolina A., Shreya Goel, Emily B. Ehlerding, et al. "Ultrasmall Porous Silica Nanoparticles with Enhanced Pharmacokinetics for Cancer Theranostics." Nano Letters 21, no. 11 (2021): 4692–99. http://dx.doi.org/10.1021/acs.nanolett.1c00895.

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28

Xu, Linxu, Fang Cui, Jiajia Zhang, Xiao Zhang, Yan Wang, and Tieyu Cui. "A general autocatalytic route toward silica nanospheres with ultrasmall sized and well-dispersed metal oxide nanoparticles." Nanoscale 10, no. 20 (2018): 9460–65. http://dx.doi.org/10.1039/c8nr02299b.

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Metal ions@silica nanospheres were prepared by our presented intramolecular autocatalytic route under neutral condition without any additional catalysts and their converse to mNPs@silica nanocomposites.
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29

Ma, Kai, Ulrike Werner-Zwanziger, Josef Zwanziger, and Ulrich Wiesner. "Controlling Growth of Ultrasmall Sub-10 nm Fluorescent Mesoporous Silica Nanoparticles." Chemistry of Materials 25, no. 5 (2013): 677–91. http://dx.doi.org/10.1021/cm303242h.

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30

Kohle, Ferdinand F. E., Songying Li, Melik Z. Turker, and Ulrich B. Wiesner. "Ultrasmall PEGylated and Targeted Core–Shell Silica Nanoparticles Carrying Methylene Blue Photosensitizer." ACS Biomaterials Science & Engineering 6, no. 1 (2019): 256–64. http://dx.doi.org/10.1021/acsbiomaterials.9b01359.

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31

Vis, Bradley, Rachel E. Hewitt, Nuno Faria, et al. "Non-Functionalized Ultrasmall Silica Nanoparticles Directly and Size-Selectively Activate T Cells." ACS Nano 12, no. 11 (2018): 10843–54. http://dx.doi.org/10.1021/acsnano.8b03363.

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32

Liu, Xiaonan, Xirui Lu, Pan Wen, Xiaoyan Shu, and Fangting Chi. "Synthesis of ultrasmall silica nanoparticles for application as deep-ultraviolet antireflection coatings." Applied Surface Science 420 (October 2017): 180–85. http://dx.doi.org/10.1016/j.apsusc.2017.05.124.

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33

Fedorenko, Svetlana V., Michail E. Jilkin, Tatyana V. Gryaznova, et al. "Silica Nanospheres Coated by Ultrasmall Ag 0 Nanoparticles for Oxidative Catalytic Application." Colloid and Interface Science Communications 21 (November 2017): 1–5. http://dx.doi.org/10.1016/j.colcom.2017.10.001.

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34

Turker, Melik Z., Kai Ma, and Ulrich Wiesner. "Bimodal Morphology Transition Pathway in the Synthesis of Ultrasmall Fluorescent Mesoporous Silica Nanoparticles." Journal of Physical Chemistry C 123, no. 14 (2019): 9582–89. http://dx.doi.org/10.1021/acs.jpcc.9b00860.

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35

Chen, Feng, Xiuli Zhang, Kai Ma, et al. "Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging." ACS Applied Materials & Interfaces 10, no. 5 (2018): 4379–93. http://dx.doi.org/10.1021/acsami.7b14362.

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36

Tsai, H. T., J. M. Córdoba, E. M. Johansson, M. A. Ballem, and M. Odén. "Silica SBA-15 Template Assisted Synthesis of Ultrasmall and Homogeneously Sized Copper Nanoparticles." Journal of Nanoscience and Nanotechnology 11, no. 4 (2011): 3493–98. http://dx.doi.org/10.1166/jnn.2011.3609.

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37

Wang, Fei, and Jian Mao. "Aerogel Constructed by Ultrasmall Mn-Doped Silica Nanoparticles for Superior Lithium-Ion Storage." ACS Applied Materials & Interfaces 13, no. 24 (2021): 28181–87. http://dx.doi.org/10.1021/acsami.1c05620.

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38

Chen, Feng, Kai Ma, Miriam Benezra, et al. "Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations." Chemistry of Materials 29, no. 20 (2017): 8766–79. http://dx.doi.org/10.1021/acs.chemmater.7b03033.

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39

Cara, Claudio, Valentina Mameli, Elisabetta Rombi, et al. "Anchoring ultrasmall FeIII-based nanoparticles on silica and titania mesostructures for syngas H2S purification." Microporous and Mesoporous Materials 298 (May 2020): 110062. http://dx.doi.org/10.1016/j.micromeso.2020.110062.

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40

Yu, Longbao, Yayu Shi, Zhen Zhao, et al. "Ultrasmall silver nanoparticles supported on silica and their catalytic performances for carbon monoxide oxidation." Catalysis Communications 12, no. 7 (2011): 616–20. http://dx.doi.org/10.1016/j.catcom.2010.12.012.

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41

Jin, Guanqiao, Pohlee Cheah, Jing Qu, Lijuan Liu, and Yongfeng Zhao. "Applications of Nanomaterials for Theranostics of Melanoma." Journal of Nanotheranostics 1, no. 1 (2020): 39–55. http://dx.doi.org/10.3390/jnt1010004.

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Melanoma is an aggressive form of skin cancer with a very high mortality rate. Early diagnosis of the disease, the utilization of more potent pharmacological agents, and more effective drug delivery systems are essential to achieve an optimal treatment plan. The applications of nanotechnology to improve therapeutic efficacy and early diagnosis for melanoma treatment have received great interest among researchers and clinicians. In this review, we summarize the recent progress of utilizing various nanomaterials for theranostics of melanoma. The key importance of using nanomaterials for theranos
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42

Sun, Yao, Hiroaki Sai, Frederick von Stein, Mark Riccio, and Ulrich Wiesner. "Water-Based Synthesis of Ultrasmall PEGylated Gold–Silica Core–Shell Nanoparticles with Long-Term Stability." Chemistry of Materials 26, no. 18 (2014): 5201–7. http://dx.doi.org/10.1021/cm501348r.

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43

Chen, Feng, Xiuli Zhang, Kai Ma, et al. "Correction to Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging." ACS Applied Materials & Interfaces 10, no. 42 (2018): 36584. http://dx.doi.org/10.1021/acsami.8b16671.

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44

Mignot, Anna, Charles Truillet, François Lux, et al. "A Top-Down Synthesis Route to Ultrasmall Multifunctional Gd-Based Silica Nanoparticles for Theranostic Applications." Chemistry - A European Journal 19, no. 19 (2013): 6122–36. http://dx.doi.org/10.1002/chem.201203003.

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45

Kankala, Ranjith Kumar, Wei-Zhi Lin, and Chia-Hung Lee. "Combating Antibiotic Resistance through the Synergistic Effects of Mesoporous Silica-Based Hierarchical Nanocomposites." Nanomaterials 10, no. 3 (2020): 597. http://dx.doi.org/10.3390/nano10030597.

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The enormous influence of bacterial resistance to antibiotics has led researchers toward the development of various advanced antibacterial modalities. In this vein, nanotechnology-based devices have garnered interest owing to their excellent morphological as well as physicochemical features, resulting in augmented therapeutic efficacy. Herein, to overcome the multidrug resistance (MDR) in bacteria, we demonstrate the fabrication of a versatile design based on the copper-doped mesoporous silica nanoparticles (Cu-MSNs). Indeed, the impregnated Cu species in the siliceous frameworks of MSNs estab
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46

Detappe, Alexandre, Eloise Thomas, Mark W. Tibbitt, et al. "Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance–Computed Tomography Image Guided Radiation Therapy." Nano Letters 17, no. 3 (2017): 1733–40. http://dx.doi.org/10.1021/acs.nanolett.6b05055.

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47

Chen, Feng, Kai Ma, Miriam Benezra, et al. "Correction to Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations." Chemistry of Materials 30, no. 20 (2018): 7322. http://dx.doi.org/10.1021/acs.chemmater.8b04072.

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48

Yan, Wenfu, Bei Chen, S. M. Mahurin, E. W. Hagaman, Sheng Dai, and Steven H. Overbury. "Surface Sol−Gel Modification of Mesoporous Silica Materials with TiO2for the Assembly of Ultrasmall Gold Nanoparticles." Journal of Physical Chemistry B 108, no. 9 (2004): 2793–96. http://dx.doi.org/10.1021/jp037713z.

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49

Biradar, Ankush V., Archana A. Biradar, and Tewodros Asefa. "Silica–Dendrimer Core–Shell Microspheres with Encapsulated Ultrasmall Palladium Nanoparticles: Efficient and Easily Recyclable Heterogeneous Nanocatalysts." Langmuir 27, no. 23 (2011): 14408–18. http://dx.doi.org/10.1021/la203066d.

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50

Benezra, Miriam, Evan Phillips, Michael Overholtzer, et al. "Ultrasmall Integrin-Targeted Silica Nanoparticles Modulate Signaling Events and Cellular Processes in a Concentration-Dependent Manner." Small 11, no. 14 (2014): 1721–32. http://dx.doi.org/10.1002/smll.201402331.

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